Page last updated: 2024-09-04

ivabradine and metoprolol

ivabradine has been researched along with metoprolol in 46 studies

Compound Research Comparison

Studies
(ivabradine)
Trials
(ivabradine)
Recent Studies (post-2010)
(ivabradine)
Studies
(metoprolol)
Trials
(metoprolol)
Recent Studies (post-2010) (metoprolol)
1,1431978335,8211,7431,304

Protein Interaction Comparison

ProteinTaxonomyivabradine (IC50)metoprolol (IC50)
Beta-2 adrenergic receptorHomo sapiens (human)2.573
Beta-1 adrenergic receptorHomo sapiens (human)0.176
Cytochrome P450 2C9 Homo sapiens (human)4.87
Cytochrome P450 2J2Homo sapiens (human)4.87

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (10.87)29.6817
2010's34 (73.91)24.3611
2020's7 (15.22)2.80

Authors

AuthorsStudies
Brockert, M; Gams, E; Langenbach, MR; Pomblum, VJ; Schepan, M; Schipke, JD; Schmitz-Spanke, S; Zirngibl, H1
Mackiewicz, U; Maczewski, M1
D'iachkov, VA; Germanov, AV; Golovin, EA; Shchukin, IuV; Surkova, EA; Vachev, AN1
Goris, M; Henning, RH; Schoemaker, RG; Ulu, N; van Gilst, WH1
Cannizzaro, S; Di Pasquale, P; Fasullo, S; Ganci, F; Giambanco, F; Maringhini, G; Migliore, G; Paterna, S; Pinto, V; Sarullo, FM; Torres, D; Vitale, G1
Dolgikh, VT; Kondrat'ev, AI; Stotskiĭ, AO1
Bouchard, B; Brownsey, R; Des Rosiers, C; Gélinas, R; Lauzier, B; Tardif, JC; Thorin, E; Vaillant, F1
Bolduc, V; Des Rosiers, C; Drouin, A; Duquette, N; Frayne-Robillard, I; Gillis, MA; Tardif, JC; Thorin, E; Thorin-Trescases, N1
Dock, W; Mendel, H; Pichler, P; Pichler-Cetin, E; Sochor, H; Syeda, B; Vertesich, M1
Becher, PM; Lindner, D; Miteva, K; Savvatis, K; Schmack, B; Schultheiss, HP; Tschöpe, C; Van Linthout, S; Westermann, D; Zietsch, C1
Chilton, RJ; Lindsey, ML; Ma, Y1
Kaczmarek, K; Klingenheben, T; Ptaszynski, P; Ruta, J; Wranicz, JK1
Adile, KK; Garg, N; Goel, PK; Gupta, A; Jain, SK; Kapoor, A; Kumar, S; Tewari, S1
Wichterle, D1
Dias, P; Gandhi, A; Ibrahim, M; Navaratnarajah, M; Sarathchandra, P; Shah, A; Siedlecka, U; Terracciano, CM; van Doorn, C; Yacoub, MH1
Alekseeva, IuM; Ardashev, AV; Fin'ko, VA; Potievskaia, VI; Sakovich, EA; Sitnikov, AV; Soiustova, EL1
Cygankiewicz, I; Kaczmarek, K; Klingenheben, T; Ptaszynski, P; Ruta, J; Wranicz, JK1
Gutzki, FM; Jordan, J; Kayacelebi, AA; Schroeder, C; Stichtenoth, DO; Suchy, MT; Tank, J; Tsikas, D; Zoerner, AA1
Gapon, LI; Kolesnikova, SN; Musikhina, NA; Petelina, TI; Utesheva, AB1
Aksu, HU; Aktürk, IF; Atasoy, I; Atasoy, MM; Celik, O; Diker, M; Ertürk, M; Yalçın, AA1
Großhennig, A; Heusser, K; Jordan, J; Luft, FC; May, M; Mehling, H; Schroeder, C; Sweep, FC; Tank, J; Wenzel, D; Zoerner, AA1
Gähwiler, R; Ghadri, JR; Lüscher, TF; Templin, C1
Chandra, S; Dwivedi, SK; Narain, VS; Puri, A; Saggu, DK; Saran, RK; Sethi, R1
Feldman, AM1
Bocchi, EA; Böhm, M; Borer, JS; Ford, I; Komajda, M; Swedberg, K; Tavazzi, L1
Ebelt, H; Höpfner, F; Müller-Werdan, U; Nuding, S; Stöckl, G; Werdan, K1
Fortmüller, U1
Agrawal, V; Kumar, N; Lohiya, B; Prajapati, R; Sihag, BK; Singh, TB; Subramanian, G1
Bolduc, V; Des Rosiers, C; Lachance, D; Lauzier, B; Rivard, ME; Ruiz, M; Shi, Y; Tardif, JC; Thorin, E; Vaillant, F1
Başaran, Ö; Biteker, M; Doğan, V; Ergün, G1
Kallistratos, M; Katsivas, A; Zarifis, J1
Kanorskiy, SG; Pokrovskiy, VM; Tregubov, VG1
Bisht, DS; Gokhroo, RK; Gupta, S; Kishore, K; Priti, K; Ranwa, BL1
Mander, GTW1
Bruckner, T; Darche, FF; Doesch, AO; Ehlermann, P; Helmschrott, M; Katus, HA; Rahm, AK; Rivinius, R; Ruhparwar, A; Thomas, D1
Hayama, Y; Kawada, T; Nishikawa, T; Shimizu, S; Shishido, T; Sugimachi, M; Uemura, K; Yamamoto, H1
Kallistratos, MS; Katsi, V; Makris, T; Manolis, AJ; Skalis, G; Tousoulis, D; Tsioufis, K1
AlDhahri, F; Kharal, M; Mahmood, N; Rajendram, R1
Bruckner, T; Darche, FF; Doesch, AO; Ehlermann, P; Helmschrott, M; Katus, HA; Rahm, AK; Rivinius, R; Thomas, D1
Grigoryeva, NY; Kolosova, KS; Samolyuk, MO; Vilkova, OE1
Mackiewicz, U; Mączewski, M; Marciszek, M; Oknińska, M; Paterek, A1
Akimov, AA; Gilarevskii, SR; Lantsova, EV1
Haberal, İ; Tekin, EE; Yeşiltaş, MA1
Abo Shabana, R; Elmansi, H; Ibrahim, F1

Reviews

2 review(s) available for ivabradine and metoprolol

ArticleYear
Ivabradine and metoprolol in fixed dose combination: When, why and how to use it.
    Pharmacological research, 2019, Volume: 146

    Topics: Adrenergic beta-Antagonists; Animals; Cardiovascular Agents; Coronary Artery Disease; Drug Combinations; Heart Rate; Humans; Ivabradine; Metoprolol

2019
[Efficacy and Safety of Combined Treament with Ivabradine and Metoprolol in Patients with Stable Angina Pectoris - a Systematic Review].
    Kardiologiia, 2020, Dec-15, Volume: 60, Issue:11

    Topics: Adrenergic beta-Antagonists; Angina, Stable; Benzazepines; Drug Therapy, Combination; Heart Rate; Humans; Ivabradine; Metoprolol; Treatment Outcome

2020

Trials

13 trial(s) available for ivabradine and metoprolol

ArticleYear
Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings.
    Journal of cardiac failure, 2009, Volume: 15, Issue:10

    Topics: Aged; Benzazepines; Double-Blind Method; Female; Follow-Up Studies; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Time Factors; Ventricular Dysfunction, Left

2009
Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography.
    The American journal of cardiology, 2012, Jan-15, Volume: 109, Issue:2

    Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Benzazepines; Coronary Angiography; Coronary Artery Disease; Cyclic Nucleotide-Gated Cation Channels; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Rate; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Myocardial Contraction; Premedication; Reproducibility of Results; Tomography, X-Ray Computed

2012
Metoprolol succinate vs. ivabradine in the treatment of inappropriate sinus tachycardia in patients unresponsive to previous pharmacological therapy.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2013, Volume: 15, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Benzazepines; Female; Humans; Ivabradine; Male; Metoprolol; Tachycardia, Sinus; Treatment Failure; Treatment Outcome

2013
Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography.
    The British journal of radiology, 2012, Volume: 85, Issue:1016

    Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzazepines; Blood Pressure; Coronary Angiography; Coronary Artery Disease; Female; Heart Rate; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Prospective Studies; Tomography, X-Ray Computed; Treatment Outcome

2012
[Cerebral blood flow and endothelial functional activity in patients with coronary heart disease and arterial hypertension during therapy with ivabradine in combination with perindopril].
    Terapevticheskii arkhiv, 2012, Volume: 84, Issue:12

    Topics: Benzazepines; Blood Flow Velocity; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Agents; Cerebrovascular Circulation; Coronary Disease; Drug Combinations; Electrocardiography; Endothelium, Vascular; Female; Heart Rate; Humans; Hypertension; Ivabradine; Male; Metoprolol; Middle Aged; Perindopril; Research Design; Treatment Outcome; Ultrasonography, Doppler

2012
Single dose ivabradine versus intravenous metoprolol for heart rate reduction before coronary computed tomography angiography (CCTA) in patients receiving long-term calcium channel-blocker therapy.
    Acta radiologica (Stockholm, Sweden : 1987), 2014, Volume: 55, Issue:6

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Benzazepines; Blood Pressure; Calcium Channel Blockers; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Injections, Intravenous; Ivabradine; Male; Metoprolol; Middle Aged; Premedication; Prospective Studies; Time

2014
Pacemaker current inhibition in experimental human cardiac sympathetic activation: a double-blind, randomized, crossover study.
    Clinical pharmacology and therapeutics, 2014, Volume: 95, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Benzazepines; Blood Pressure; Cardiotonic Agents; Cross-Over Studies; Double-Blind Method; Endpoint Determination; Heart; Heart Rate; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ivabradine; Male; Metoprolol; Morpholines; Muscle Proteins; Norepinephrine; Orthostatic Intolerance; Pacemaker, Artificial; Potassium Channels; Reboxetine; Stroke Volume; Sympathetic Nervous System; Syncope; Young Adult

2014
Effect of Ivabradine on Heart Rate and Duration of Exercise in Patients With Mild-to-Moderate Mitral Stenosis: A Randomized Comparison With Metoprolol.
    Journal of cardiovascular pharmacology, 2015, Volume: 65, Issue:6

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Anti-Arrhythmia Agents; Benzazepines; Cross-Over Studies; Echocardiography, Doppler; Echocardiography, Stress; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; India; Ivabradine; Male; Maximum Tolerated Dose; Metoprolol; Mitral Valve Stenosis; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult

2015
Effect of Combining Ivabradine and β-Blockers: Focus on the Use of Carvedilol in the SHIFT Population.
    Cardiology, 2015, Volume: 131, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Benzazepines; Bisoprolol; Carbazoles; Cardiovascular Agents; Carvedilol; Double-Blind Method; Drug Therapy, Combination; Female; Heart Failure, Systolic; Hospitalization; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Nebivolol; Propanolamines; Proportional Hazards Models; Treatment Outcome

2015
Ivabradine in Combination with Metoprolol Improves Symptoms and Quality of Life in Patients with Stable Angina Pectoris: A post hoc Analysis from the ADDITIONS Trial.
    Cardiology, 2016, Volume: 133, Issue:2

    Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Angina, Stable; Benzazepines; Cardiovascular Agents; Drug Therapy, Combination; Female; Germany; Heart Rate; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Nitrates; Prospective Studies; Quality of Life; Surveys and Questionnaires

2016
Metoprolol vs ivabradine in patients with mitral stenosis in sinus rhythm.
    International journal of cardiology, 2016, Oct-15, Volume: 221

    Topics: Adolescent; Adult; Benzazepines; Cardiovascular Agents; Drug Monitoring; Echocardiography; Electrocardiography, Ambulatory; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; Ivabradine; Male; Metoprolol; Mitral Valve Stenosis; Symptom Assessment; Treatment Outcome

2016
Metoprolol vs ivabradine in patients with mitral stenosis.
    International journal of cardiology, 2016, Nov-15, Volume: 223

    Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzazepines; Cardiovascular Agents; Electrocardiography; Female; Follow-Up Studies; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Mitral Valve Stenosis; Retrospective Studies; Treatment Outcome; Young Adult

2016
Ivabradine vs metoprolol in patients with acute inferior wall myocardial infarction-"Expanding arena for ivabradine".
    Cardiovascular therapeutics, 2017, Volume: 35, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Atrioventricular Block; Benzazepines; Cardiotonic Agents; Double-Blind Method; Electrocardiography; Endpoint Determination; Female; Heart Block; Heart Failure; Humans; Inferior Wall Myocardial Infarction; Ivabradine; Male; Metoprolol; Middle Aged; Prospective Studies; Recurrence; Survival Analysis

2017

Other Studies

31 other study(ies) available for ivabradine and metoprolol

ArticleYear
Comparison of a beta-blocker and an If current inhibitor in rabbits with myocardial infarction.
    The Journal of cardiovascular surgery, 2006, Volume: 47, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Aorta; Benzazepines; Blood Flow Velocity; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Electrocardiography; Heart Rate; Heart Ventricles; Ivabradine; Male; Metoprolol; Myocardial Contraction; Myocardial Infarction; Natriuretic Peptide, Brain; Oxygen Consumption; Potassium Channel Blockers; Rabbits; Time Factors; Ventricular Function, Left; Ventricular Myosins

2006
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart.
    Cardiovascular research, 2008, Jul-01, Volume: 79, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Benzazepines; Calcium; Disease Models, Animal; Heart Failure; Heart Rate; Hypertrophy, Left Ventricular; Ivabradine; Male; Metoprolol; Myocardial Infarction; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Calcium Exchanger; Ventricular Remodeling

2008
[The role of beta-adrenoblockers and If-inhibitor ivabradine in lowering of rate of development of cardiac complications after carotid endarterectomy].
    Kardiologiia, 2008, Volume: 48, Issue:5

    Topics: Adrenergic beta-Antagonists; Benzazepines; Carotid Artery Diseases; Drug Therapy, Combination; Endarterectomy, Carotid; Follow-Up Studies; Humans; Incidence; Ivabradine; Metoprolol; Middle Aged; Myocardial Infarction; Postoperative Complications; Retrospective Studies; Russia; Stereoisomerism; Treatment Outcome

2008
Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure.
    Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:1

    Topics: Animals; Benzazepines; Heart Failure; Heart Rate; Ivabradine; Male; Metoprolol; Myocardial Infarction; Rats; Rats, Wistar; Ventricular Dysfunction, Left

2009
[Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus].
    Terapevticheskii arkhiv, 2010, Volume: 82, Issue:1

    Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Adult; Benzazepines; Diabetes Mellitus, Type 2; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heart Failure; Heart Rate; Humans; Hypoglycemic Agents; Ivabradine; Male; Metoprolol; Middle Aged; Treatment Outcome; Ventricular Function, Left

2010
Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Benzazepines; Cardiac Output; Energy Metabolism; Heart; Heart Rate; Ivabradine; Male; Metoprolol; Mice; Mice, Inbred C57BL; Myocardium; Oxygen Consumption

2011
Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Apolipoproteins B; Atherosclerosis; Benzazepines; Carotid Arteries; Carotid Artery Diseases; Cerebral Arteries; Cerebrovascular Disorders; Compliance; Disease Models, Animal; Disease Progression; Dyslipidemias; Endothelium, Vascular; Exercise Therapy; Genotype; Heart Rate; Humans; Ivabradine; Male; Matrix Metalloproteinase 9; Metoprolol; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type III; Phenotype; Receptors, LDL; Severity of Illness Index; Stress, Mechanical; Time Factors; Vasodilation

2011
Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:5

    Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin II; Animals; Apoptosis; Benzazepines; Cyclic Nucleotide-Gated Cation Channels; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Failure; Heart Rate; Immunohistochemistry; In Situ Nick-End Labeling; Ivabradine; Male; Metoprolol; Mice; Mice, Inbred C57BL; Multivariate Analysis; Random Allocation; Sensitivity and Specificity; Statistics, Nonparametric; Tachycardia; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Remodeling

2012
Heart rate reduction: an old and novel candidate heart failure therapy.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:5

    Topics: Animals; Benzazepines; Heart Failure; Ivabradine; Male; Metoprolol; Tachycardia; Ventricular Dysfunction, Left

2012
Ivabradine for inappropriate sinus tachycardia: another piece of evidence.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2013, Volume: 15, Issue:1

    Topics: Benzazepines; Female; Humans; Ivabradine; Male; Metoprolol; Tachycardia, Sinus

2013
Influence of ivabradine on reverse remodelling during mechanical unloading.
    Cardiovascular research, 2013, Feb-01, Volume: 97, Issue:2

    Topics: Animals; Atrophy; Benzazepines; Calcium; Calcium Channels, L-Type; Excitation Contraction Coupling; Fibrosis; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; Ivabradine; Metoprolol; Myocardium; Rats; Ventricular Remodeling

2013
[The rare case of Bland-White-Garland syndrome in adult patient].
    Kardiologiia, 2012, Volume: 52, Issue:11

    Topics: Adult; Benzazepines; Cardiovascular Agents; Cardiovascular Surgical Procedures; Coronary Angiography; Coronary Vessel Anomalies; Coronary Vessels; Female; Heart Failure; Humans; Ivabradine; Metoprolol; Mitral Valve Insufficiency; Multidetector Computed Tomography; Prognosis; Pulmonary Artery; Syndrome; Treatment Outcome

2012
Ivabradine in combination with metoprolol succinate in the treatment of inappropriate sinus tachycardia.
    Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Benzazepines; Drug Resistance; Drug Therapy, Combination; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Tachycardia, Sinus; Treatment Outcome

2013
A validated, rapid UPLC-MS/MS method for simultaneous ivabradine, reboxetine, and metoprolol analysis in human plasma and its application to clinical trial samples.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, May-15, Volume: 927

    Topics: Benzazepines; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Drug Stability; Humans; Ivabradine; Linear Models; Male; Metoprolol; Morpholines; Randomized Controlled Trials as Topic; Reboxetine; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2013
[A heart without overspeed trip unit].
    Praxis, 2014, Apr-23, Volume: 103, Issue:9

    Topics: Adult; Algorithms; Benzazepines; Bisoprolol; Diagnosis, Differential; Drug Therapy, Combination; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Exercise Test; Firefighters; Humans; Ivabradine; Male; Metoprolol; Oxygen; Physical Examination; Physical Fitness; Signal Processing, Computer-Assisted; Tachycardia, Sinus; Ventricular Dysfunction, Left

2014
Ivabradine in Cardiovascular Disease: Heart Rate Isn't Everything.
    Journal of cardiovascular pharmacology, 2015, Volume: 65, Issue:6

    Topics: Adrenergic beta-1 Receptor Antagonists; Anti-Arrhythmia Agents; Benzazepines; Exercise Tolerance; Female; Heart Rate; Humans; Ivabradine; Male; Metoprolol; Mitral Valve Stenosis

2015
[First fixed combination becomes available].
    MMW Fortschritte der Medizin, 2016, May-25, Volume: 158, Issue:10

    Topics: Angina Pectoris; Benzazepines; Coronary Disease; Drug Combinations; Humans; Ivabradine; Metoprolol

2016
[Anti-angina fixed combination is available].
    MMW Fortschritte der Medizin, 2016, Apr-28, Volume: 158, Issue:8

    Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Benzazepines; Cardiovascular Agents; Combined Modality Therapy; Coronary Disease; Drug Combinations; Humans; Ivabradine; Metoprolol; Recurrence

2016
[Increased physical capacity].
    MMW Fortschritte der Medizin, 2016, May-12, Volume: 158, Issue:9

    Topics: Angina Pectoris; Benzazepines; Cardiovascular Agents; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Drug Combinations; Humans; Ivabradine; Metoprolol; Physical Fitness

2016
Ivabradine and metoprolol differentially affect cardiac glucose metabolism despite similar heart rate reduction in a mouse model of dyslipidemia.
    American journal of physiology. Heart and circulatory physiology, 2016, 10-01, Volume: 311, Issue:4

    Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Benzazepines; Bradycardia; Cardiovascular Agents; Disease Models, Animal; Dyslipidemias; Echocardiography; Energy Metabolism; Female; Glucose; Glycolysis; Heart; Heart Rate; Hemodynamics; Ivabradine; Longitudinal Studies; Male; Metoprolol; Mice; Myocardium; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stroke Volume; Telemetry; Transcriptome

2016
Antianginal Efficacy of Ivabradine/Metoprolol Combination in Patients With Stable Angina.
    Clinical cardiology, 2016, Volume: 39, Issue:12

    Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Angina, Stable; Benzazepines; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Ivabradine; Male; Metoprolol; Prospective Studies; Quality of Life; Surveys and Questionnaires; Treatment Outcome

2016
[Regulatory Adaptive Status in Assessment of Efficacy of Pharmacotherapy and Prognostication of Complications in Functional Class III Chronic Heart Failure].
    Kardiologiia, 2016, Volume: 56, Issue:1

    Topics: Aged; Benzazepines; Cardiovascular Agents; Chronic Disease; Echocardiography; Exercise Test; Female; Heart Failure; Humans; Hypertension; Ivabradine; Male; Metoprolol; Middle Aged; Quinapril; Random Allocation; Spironolactone; Tetrahydroisoquinolines; Treatment Outcome; Ventricular Function, Left

2016
Computed tomography coronary angiography with heart rate control premedication: a best practice implementation project.
    JBI database of systematic reviews and implementation reports, 2017, Volume: 15, Issue:7

    Topics: Administration, Intravenous; Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Australia; Benzazepines; Computed Tomography Angiography; Coronary Angiography; Evidence-Based Practice; Guideline Adherence; Heart Rate; Humans; Ivabradine; Medical Audit; Metoprolol; Practice Guidelines as Topic; Premedication

2017
Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2018, Volume: 107, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Benzazepines; Female; Germany; Heart; Heart Rate; Heart Transplantation; Humans; Hypertrophy, Left Ventricular; Ivabradine; Kaplan-Meier Estimate; Male; Metoprolol; Middle Aged; Retrospective Studies; Risk Factors; Tachycardia, Sinus; Time Factors; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling

2018
Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats.
    The journal of physiological sciences : JPS, 2019, Volume: 69, Issue:2

    Topics: Animals; Blood Pressure; Bradycardia; Heart Rate; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ivabradine; Male; Metoprolol; Rats; Rats, Inbred WKY; Sympathetic Nervous System

2019
The use of ivabradine in a patient with inappropriate sinus tachycardia and cardiomyopathy due to limb girdle muscular dystrophy type 2I.
    BMJ case reports, 2020, Jan-21, Volume: 13, Issue:1

    Topics: Anti-Arrhythmia Agents; Cardiomyopathies; Cardiovascular Agents; Diagnosis, Differential; Female; Humans; Ivabradine; Metoprolol; Muscular Dystrophies, Limb-Girdle; Tachycardia, Sinus; Young Adult

2020
Five-year results of heart rate control with ivabradine or metoprolol succinate in patients after heart transplantation.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2022, Volume: 111, Issue:2

    Topics: Anti-Arrhythmia Agents; Female; Heart Rate; Heart Transplantation; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Postoperative Complications; Registries; Tachycardia, Sinus; Treatment Outcome

2022
[New opportunities to improve the treatment effectiveness of patients with stable angina].
    Kardiologiia, 2020, Jul-07, Volume: 60, Issue:6

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Stable; Drug Therapy, Combination; Female; Heart Rate; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Treatment Outcome

2020
Ivabradine is as effective as metoprolol in the prevention of ventricular arrhythmias in acute non-reperfused myocardial infarction in the rat.
    Scientific reports, 2020, 09-14, Volume: 10, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Signaling; Cells, Cultured; Heart Rate; Ivabradine; Male; Metoprolol; Myocardial Infarction; Myocytes, Cardiac; Rats; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Tachycardia, Ventricular; Ventricular Fibrillation

2020
Short-Term Results of Ivabradine versus Metoprolol: The Effects on Atrial Fibrillation in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.
    Brazilian journal of cardiovascular surgery, 2022, 12-01, Volume: 37, Issue:6

    Topics: Atrial Fibrillation; Coronary Artery Bypass; Humans; Hypotension; Ivabradine; Metoprolol; Postoperative Complications

2022
Utility of synchronous fluorimetry for the concurrent quantitation of metoprolol and ivabradine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2022, Nov-05, Volume: 280

    Topics: Fluorometry; Ivabradine; Metoprolol; Spectrometry, Fluorescence

2022