Page last updated: 2024-09-04

ivabradine and digoxin

ivabradine has been researched along with digoxin in 18 studies

Compound Research Comparison

Studies
(ivabradine)
Trials
(ivabradine)
Recent Studies (post-2010)
(ivabradine)
Studies
(digoxin)
Trials
(digoxin)
Recent Studies (post-2010) (digoxin)
1,14319783311,4839581,289

Protein Interaction Comparison

ProteinTaxonomyivabradine (IC50)digoxin (IC50)
STAT3, partialHomo sapiens (human)1.862
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)0.32
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)0.0055
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.19
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-1Canis lupus familiaris (dog)0.5
Nuclear receptor ROR-gammaHomo sapiens (human)3.4798
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0055
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.2359

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's13 (72.22)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Boos, C; Gorman, S1
Akchurin, RS; Chernova, NA; Erastova, NV; Grishin, IR; Karpov, IuA; Latypov, RS; Lopukhova, VV; Mareev, IuV; Saidova, MA; Sapel'nikov, OV1
Alabd, A; Gamal, A; Rayan, M; Tawfik, M1
Castagno, D; Claggett, B; McMurray, J; Petrie, MC1
Drożdż, J; Filipiak, KJ; Grajek, S; Kasprzak, JD; Opolski, G; Rynkiewicz, A; Stępińska, J; Tykarski, A; Wożakowska Kapłon, B1
Lim, WY; Woldman, S1
Eriksson, U; Müller-Edenborn, B1
Enseleit, F; Flammer, AJ; Naegele, M; Ruschitzka, F1
Korabathina, R; Wojnowich, K1
Hensey, M; O'Neill, J1
Adhyaru, B; Raj, L1
Wu, A1
Andrey, JL; Aranda, R; Egido, J; Gomez, F; Gomez, R; Guzman, M; Pedrosa, MJ; Romero, SP1
Asselbergs, FW; Bots, SH; Day, D; den Ruijter, HM; Eikendal, ALM; Groepenhoff, F; Miller, VM; Regitz-Zagrosek, V; Rochon, PA; Tannenbaum, C1
Arias, MÁ; Arribas, F; Fontenla, A; Gómez de la Cámara, A; López-Gil, M; Matía-Francés, R; Mejía-Martínez, E; Miracle-Blanco, Á; Montilla, I; Pastor-Fuentes, A; Rey-Blas, JR; Salgado-Aranda, R; Tamargo-Menéndez, J; Toquero-Ramos, J1
Bosco-Lévy, P; Droz-Perroteau, C; Favary, C; Jové, J; Lassalle, R; Moore, N1
Chang, HY; Chen, CH; Lan, WR; Lee, YH; Liao, FC; Lin, SI; Liu, PY; Tsai, CT; Wu, YJ1
Bueno, H; Fontenla, A; García-Fernandez, FJ; López-Gil, M; Matía, R; Mejía, E; Miracle, A; Montilla, I; Rajjoub, EA; Rey, JR; Salgado, R; Tamargo, J; Toquero, J1

Reviews

9 review(s) available for ivabradine and digoxin

ArticleYear
Pharmacological management of chronic heart failure: old drugs, new drugs and new indications.
    British journal of hospital medicine (London, England : 2005), 2013, Volume: 74, Issue:2

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Cardiovascular Agents; Chronic Disease; Digoxin; Drug Combinations; Heart Failure; Heart Failure, Systolic; Humans; Hydralazine; Isosorbide Dinitrate; Ivabradine; Mineralocorticoid Receptor Antagonists

2013
[Heart failure - up to date].
    Praxis, 2013, Aug-21, Volume: 102, Issue:17

    Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Cardiotonic Agents; Digoxin; Diuretics; Drug Therapy, Combination; Evidence-Based Medicine; Heart Failure; Hemodynamics; Humans; Ivabradine; Mineralocorticoid Receptor Antagonists; Patient Readmission; Quality of Life; Survival Rate; Ventricular Dysfunction, Left

2013
Medical therapy of heart failure with reduced ejection fraction: current evidence and new developments.
    Swiss medical weekly, 2016, Volume: 146

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Cardiotonic Agents; Cardiovascular Agents; Digoxin; Diuretics; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Ivabradine; Mineralocorticoid Receptor Antagonists; Neprilysin; Stroke Volume; Vasodilator Agents

2016
Heart Failure Update: Outpatient Management.
    FP essentials, 2016, Volume: 442

    Topics: Adrenergic beta-Antagonists; Aged; Ambulatory Care; Aminobutyrates; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Biphenyl Compounds; Cardiac Resynchronization Therapy; Cardiotonic Agents; Cardiovascular Agents; Diet, Sodium-Restricted; Digoxin; Diuretics; Drug Combinations; Exercise Therapy; Fatty Acids, Omega-3; Female; Heart Failure; Heart Transplantation; Hospice Care; Humans; Ivabradine; Mineralocorticoid Receptor Antagonists; Tetrazoles; Valsartan; Vasodilator Agents

2016
Is Heart Rate a Norepiphenomenon in Heart Failure?
    Current cardiology reports, 2016, Volume: 18, Issue:9

    Topics: Adrenergic Antagonists; Amiodarone; Benzazepines; Depression, Chemical; Digoxin; Evidence-Based Medicine; Heart Failure; Heart Rate; Humans; Ivabradine

2016
An evidence-based review of recent advances in therapy for heart failure with reduced ejection fraction (HFrEF).
    Postgraduate medical journal, 2016, Volume: 92, Issue:1094

    Topics: Adrenergic beta-Antagonists; American Heart Association; Amides; Aminobutyrates; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Antihypertensive Agents; Atrial Natriuretic Factor; Benzazepines; Biphenyl Compounds; Calcium Channel Blockers; Cardiology; Cardiotonic Agents; Cardiovascular Agents; Digoxin; Diuretics; Drug Combinations; Erythropoietin; Evidence-Based Medicine; Fumarates; Heart Failure; Hematinics; Humans; Hydralazine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iron; Isosorbide Dinitrate; Ivabradine; Mineralocorticoid Receptor Antagonists; Peptide Fragments; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Societies, Medical; Stroke Volume; Tetrazoles; United States; Valsartan; Vasodilator Agents

2016
Heart Failure.
    Annals of internal medicine, 2018, 06-05, Volume: 168, Issue:11

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Cardiac Rehabilitation; Cardiovascular Agents; Coronary Artery Disease; Defibrillators, Implantable; Diabetes Complications; Diagnostic Techniques, Cardiovascular; Digoxin; Diuretics; Heart Failure; Hospitalization; Humans; Hydralazine; Hypertension; Isosorbide Dinitrate; Ivabradine; Life Style; Mineralocorticoid Receptor Antagonists; Palliative Care; Primary Prevention; Referral and Consultation; Risk Factors

2018
Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the Literature.
    JACC. Heart failure, 2019, Volume: 7, Issue:3

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Cardiovascular Agents; Digoxin; Drug-Related Side Effects and Adverse Reactions; Female; Heart Failure; Humans; Ivabradine; Male; Mineralocorticoid Receptor Antagonists; Mortality; Practice Guidelines as Topic; Research Design; Research Report; Sex Distribution; Sex Factors; Stroke Volume

2019
Effect of Reducing Heart Rate on Outcomes in Patients With Reduced Ejection Fraction.
    The American journal of cardiology, 2021, 07-01, Volume: 150

    Topics: Cardiovascular Agents; Digoxin; Heart Failure; Heart Rate; Humans; Ivabradine; Stroke Volume; Tachycardia

2021

Trials

3 trial(s) available for ivabradine and digoxin

ArticleYear
Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy?
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2011, Volume: 11, Issue:5

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzazepines; Carbazoles; Cardiomyopathy, Dilated; Cardiotonic Agents; Carvedilol; Digoxin; Diuretics; Drug Therapy, Combination; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Propanolamines; Prospective Studies; Spironolactone; Vasodilator Agents; Ventricular Premature Complexes

2011
Ivabradine for chronic heart rate control in persistent atrial fibrillation. Design of the BRAKE-AF project.
    Revista espanola de cardiologia (English ed.), 2020, Volume: 73, Issue:5

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiovascular Agents; Digoxin; Equivalence Trials as Topic; Heart Rate; Humans; Ivabradine; Treatment Outcome

2020
Ivabradine for controlling heart rate in permanent atrial fibrillation: A translational clinical trial.
    Heart rhythm, 2023, Volume: 20, Issue:6

    Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Digoxin; Heart Rate; Humans; Ivabradine

2023

Other Studies

6 other study(ies) available for ivabradine and digoxin

ArticleYear
Ivabradine in heart failure: what about digoxin?
    Lancet (London, England), 2008, Dec-20, Volume: 372, Issue:9656

    Topics: Adrenergic beta-Antagonists; Benzazepines; Cardiotonic Agents; Confounding Factors, Epidemiologic; Digoxin; Drug Therapy, Combination; Heart Failure; Humans; Ivabradine

2008
[Application of cardiac resynchronization therapy and ivabradine in a patient with chronic heart failure].
    Kardiologiia, 2010, Volume: 50, Issue:7

    Topics: Benzazepines; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiovascular Agents; Digoxin; Diuretics; Echocardiography; Electrocardiography; Furosemide; Heart Atria; Heart Failure; Heart Rate; Heart Ventricles; Humans; Ivabradine; Male; Middle Aged; Myocardial Infarction; Spironolactone; Treatment Outcome

2010
Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.
    European heart journal, 2012, Volume: 33, Issue:9

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Digoxin; Female; Heart Failure; Humans; Ivabradine; Kaplan-Meier Estimate; Male; Middle Aged; Randomized Controlled Trials as Topic; Retrospective Studies; Stroke Volume; Treatment Outcome; Ventricular Dysfunction, Left

2012
[Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].
    Kardiologia polska, 2012, Volume: 70, Issue:10

    Topics: Adrenergic beta-Agonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Digoxin; Diltiazem; Heart Diseases; Heart Rate; Humans; Hypertension; Ivabradine; Verapamil

2012
Prognosis of heart failure treated with digoxin or with ivabradine: A cohort study in the community.
    International journal of clinical practice, 2018, Volume: 72, Issue:11

    Topics: Adrenergic beta-Antagonists; Aged; Cardiotonic Agents; Cardiovascular Agents; Cohort Studies; Comorbidity; Digoxin; Female; Heart Failure; Hospitalization; Humans; Ivabradine; Male; Patient Readmission; Prognosis; Stroke Volume; Treatment Outcome

2018
Pharmacological treatment patterns in heart failure: a population-based cohort study.
    European journal of clinical pharmacology, 2020, Volume: 76, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Agents; Clinical Protocols; Cohort Studies; Digoxin; Diuretics; Drug Substitution; Female; France; Heart Failure; Hospitalization; Humans; Ivabradine; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Time Factors

2020