Page last updated: 2024-09-04

ivabradine and carvedilol

ivabradine has been researched along with carvedilol in 19 studies

Compound Research Comparison

Studies
(ivabradine)
Trials
(ivabradine)
Recent Studies (post-2010)
(ivabradine)
Studies
(carvedilol)
Trials
(carvedilol)
Recent Studies (post-2010) (carvedilol)
1,1431978332,9336801,052

Protein Interaction Comparison

ProteinTaxonomyivabradine (IC50)carvedilol (IC50)
Solute carrier family 22 member 2Homo sapiens (human)7.5
Solute carrier family 22 member 1 Homo sapiens (human)3.4
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.115
Potassium channel subfamily K member 2Homo sapiens (human)1.6
Beta-2 adrenergic receptorHomo sapiens (human)0.0002
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.538
ATP-dependent translocase ABCB1Homo sapiens (human)5.7333
Beta-1 adrenergic receptorHomo sapiens (human)0.0002
Alpha-2A adrenergic receptorHomo sapiens (human)0.106
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)4.1193
Beta-3 adrenergic receptorHomo sapiens (human)0.0042
D(2) dopamine receptorHomo sapiens (human)0.146
Alpha-2B adrenergic receptorHomo sapiens (human)0.094
Alpha-2C adrenergic receptorHomo sapiens (human)0.09
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0058
D(1A) dopamine receptorHomo sapiens (human)1.498
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.538
Alpha-1D adrenergic receptorHomo sapiens (human)0.0018
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.41
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.115
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.0058
Sodium-dependent serotonin transporterHomo sapiens (human)0.221
D(3) dopamine receptorHomo sapiens (human)0.577
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.023
5-hydroxytryptamine receptor 6Homo sapiens (human)1.519
Potassium channel subfamily K member 10Homo sapiens (human)7.6
Sodium-dependent dopamine transporter Homo sapiens (human)0.845
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.2346
Cytochrome P450 1B1Homo sapiens (human)1.1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)4.1193

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's15 (78.95)24.3611
2020's4 (21.05)2.80

Authors

AuthorsStudies
Alabd, A; Gamal, A; Rayan, M; Tawfik, M1
Acquistapace, F; Caminiti, G; Cice, G; D'Isa, S; Fini, M; Marazzi, G; Perrone Filardi, P; Rosano, GM; Vitale, C; Volterrani, M1
Francis, GS; Sarraf, M1
Jia-Feng, L; Li-Sha, G; Na-Dan, Z; Qin, L; Teng, Z; Xue-Qiang, G; Yue-Chun, L1
Benvenuto, A; Masciocco, L; Prencipe, G; Riccioni, G; Rizzo, U; Russi, C; Speziale, G; Ventra, S1
Chen, YH; Ge, LS; Guan, XQ; Li, YC; Lin, JF; Luo, Q; Zhang, T; Zhou, ND1
Benvenuto, A; Buta, F; De Viti, D; Masciocco, L; Massari, F; Meliota, G; Riccioni, G; Saracino, P; Speziale, G1
Bagriy, AE; Bagriy, EA; Malovichko, SI; Pricolota, AV; Pricolota, OA; Samoilova, OV; Schukina, EV1
Ilashchuk, T; Okipniak, I; Shirokova, S1
Bocchi, EA; Böhm, M; Borer, JS; Ford, I; Komajda, M; Swedberg, K; Tavazzi, L1
Al-Saadi, T; Al-Zakwani, I; Alshekaili, L; Sallam, M1
Bijnens, B; Friedberg, MK; Gomez, O; Honjo, O; Ishii, R; Okumura, K; Sun, M1
Guang-Yi, C; Li-Sha, G; Yue-Chun, L1
Williams, MR1
Acquistapace, F; Caminiti, G; Cice, G; D'Isa, S; Filardi, PP; Fini, M; Marazzi, G; Rosano, GMC; Vitale, C; Volterrani, M1
Goyal, R; Khumuckham, JS; Kumar, G; Premkumar, M; Rangegowda, D; Sarin, SK; Shasthry, SM; Thomas, SS; Vyas, T1
Naik, K; Prajapati, P; Shah, S; Tailor, P1
Elsayed, SS; Ibrahim, FA; Nasr, JJM; Rashad, EA1
Chang, S; Lu, S; Shen, L; Tong, X; Wang, Y; Zhou, X1

Reviews

3 review(s) available for ivabradine and carvedilol

ArticleYear
β-blockers in stage B: a precursor of heart failure.
    Heart failure clinics, 2012, Volume: 8, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Benzazepines; Bisoprolol; Carbazoles; Cardiovascular System; Carvedilol; Disease Progression; Heart Failure; Heart Ventricles; Humans; Ivabradine; Propanolamines; Sympathetic Nervous System; Ventricular Dysfunction, Left

2012
Role of Heart Rate Reduction in the Management of Myocarditis.
    Current pharmaceutical design, 2018, Volume: 24, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Cardiovascular Agents; Carvedilol; Heart Rate; Humans; Inflammation; Ivabradine; Myocarditis

2018
Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis.
    Drugs in R&D, 2023, Volume: 23, Issue:3

    Topics: Cardiomyopathy, Dilated; Carvedilol; Humans; Ivabradine; Network Meta-Analysis; Randomized Controlled Trials as Topic; Stroke Volume; Trimetazidine; Ventricular Function, Left; Verapamil

2023

Trials

7 trial(s) available for ivabradine and carvedilol

ArticleYear
Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy?
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2011, Volume: 11, Issue:5

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzazepines; Carbazoles; Cardiomyopathy, Dilated; Cardiotonic Agents; Carvedilol; Digoxin; Diuretics; Drug Therapy, Combination; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Propanolamines; Prospective Studies; Spironolactone; Vasodilator Agents; Ventricular Premature Complexes

2011
Effect of Carvedilol, Ivabradine or their combination on exercise capacity in patients with Heart Failure (the CARVIVA HF trial).
    International journal of cardiology, 2011, Sep-01, Volume: 151, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Benzazepines; Carbazoles; Carvedilol; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Heart Failure; Humans; Ivabradine; Male; Propanolamines; Prospective Studies; Quality of Life; Single-Blind Method; Treatment Outcome

2011
Ivabradine improves all aspects of quality of life assessed with the 36-item short form health survey in subjects with chronic ischemic heart disease compared with beta-blockers.
    Pharmacology, 2013, Volume: 91, Issue:1-2

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Stable; Atenolol; Benzazepines; Bisoprolol; Carbazoles; Carvedilol; Female; Health Surveys; Humans; Ivabradine; Male; Middle Aged; Propanolamines; Quality of Life

2013
Ivabradine improves quality of life in subjects with chronic heart failure compared to treatment with β-blockers: results of a multicentric observational APULIA study.
    Pharmacology, 2013, Volume: 92, Issue:5-6

    Topics: Adrenergic beta-Antagonists; Aged; Benzazepines; Bisoprolol; Blood Pressure; Carbazoles; Carvedilol; Chronic Disease; Female; Heart Failure; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Propanolamines; Quality of Life; Surveys and Questionnaires; Treatment Outcome

2013
Effect of Combining Ivabradine and β-Blockers: Focus on the Use of Carvedilol in the SHIFT Population.
    Cardiology, 2015, Volume: 131, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Benzazepines; Bisoprolol; Carbazoles; Cardiovascular Agents; Carvedilol; Double-Blind Method; Drug Therapy, Combination; Female; Heart Failure, Systolic; Hospitalization; Humans; Ivabradine; Male; Metoprolol; Middle Aged; Nebivolol; Propanolamines; Proportional Hazards Models; Treatment Outcome

2015
Impact of Ivabradine on Health-Related Quality of Life of Patients with Ischaemic Chronic Heart Failure.
    Current vascular pharmacology, 2016, Volume: 14, Issue:5

    Topics: Adrenergic Antagonists; Aged; Benzazepines; Carbazoles; Cardiovascular Agents; Carvedilol; Chronic Disease; Drug Therapy, Combination; Female; Heart Failure; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Oman; Propanolamines; Prospective Studies; Quality of Life; Stroke Volume; Surveys and Questionnaires; Time Factors; Treatment Outcome; Ventricular Function, Left

2016
Carvedilol Combined With Ivabradine Improves Left Ventricular Diastolic Dysfunction, Clinical Progression, and Survival in Cirrhosis.
    Journal of clinical gastroenterology, 2020, Volume: 54, Issue:6

    Topics: Carvedilol; End Stage Liver Disease; Humans; Ivabradine; Liver Cirrhosis; Severity of Illness Index

2020

Other Studies

9 other study(ies) available for ivabradine and carvedilol

ArticleYear
Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Benzazepines; Carbazoles; Carvedilol; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Enterovirus B, Human; Heart; Heart Rate; Ivabradine; Male; Mice; Myocardial Contraction; Myocarditis; Myocardium; Oxidative Stress; Propanolamines

2012
Ivabradine inhibits the production of proinflammatory cytokines and inducible nitric oxide synthase in acute coxsackievirus B3-induced myocarditis.
    Biochemical and biophysical research communications, 2013, Feb-15, Volume: 431, Issue:3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Benzazepines; Carbazoles; Carvedilol; Coxsackievirus Infections; Cytokines; Gene Expression; Ivabradine; Male; Mice; Mice, Inbred BALB C; Myocarditis; Nitric Oxide; Nitric Oxide Synthase Type II; Propanolamines

2013
Addition of ivabradine to β-blocker improves exercise capacity in systolic heart failure patients in a prospective, open-label study.
    Advances in therapy, 2015, Volume: 32, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Benzazepines; Carbazoles; Cardiovascular Agents; Carvedilol; Drug Therapy, Combination; Exercise; Exercise Tolerance; Female; Heart Failure, Systolic; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Propanolamines; Prospective Studies; Risk Factors; Ventricular Dysfunction, Left

2015
[The comparative effectiveness of beta-blockers and inhibitors of if-iodium using in patients with stable angina pectoris].
    Georgian medical news, 2015, Issue:240

    Topics: Adrenergic beta-Antagonists; Angina, Stable; Benzazepines; Bisoprolol; Carbazoles; Carvedilol; Electrocardiography; Female; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Myocardial Ischemia; Propanolamines

2015
Heart rate reduction improves biventricular function and interactions in experimental pulmonary hypertension.
    American journal of physiology. Heart and circulatory physiology, 2018, 03-01, Volume: 314, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Carvedilol; Disease Models, Animal; Drug Therapy, Combination; Heart Rate; Hypertension, Pulmonary; Ivabradine; Male; Monocrotaline; Rats, Sprague-Dawley; Recovery of Function; Time Factors; Ventricular Function, Left; Ventricular Function, Right

2018
The CARVIVA HF trial- Is the devil in the detail?
    International journal of cardiology, 2019, 01-01, Volume: 274

    Topics: Carvedilol; Exercise; Heart Failure; Humans; Ivabradine

2019
Response letter to Dr. William's letter to the editor entitled "The CARVIVA HF trial - Is the devil in the detail?" published August 2018.
    International journal of cardiology, 2019, 08-01, Volume: 288

    Topics: Carvedilol; Exercise; Exercise Tolerance; Heart Failure; Humans; Ivabradine

2019
Screening Design and Response Surface Methodology for the Simultaneous Estimation of Carvedilol and Ivabradine HCl by HPTLC Method.
    Journal of chromatographic science, 2022, Nov-05, Volume: 60, Issue:9

    Topics: Carvedilol; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Chromatography, Thin Layer; Humans; Ivabradine

2022
New ecological first derivative synchronous spectrofluorimetric method for simultaneous quantification of carvedilol and ivabradine in tablets.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023, Mar-15, Volume: 289

    Topics: Carvedilol; Ivabradine; Solvents; Spectrometry, Fluorescence; Tablets

2023