Page last updated: 2024-09-04

ivabradine and amiodarone

ivabradine has been researched along with amiodarone in 8 studies

Compound Research Comparison

Studies
(ivabradine)
Trials
(ivabradine)
Recent Studies (post-2010)
(ivabradine)
Studies
(amiodarone)
Trials
(amiodarone)
Recent Studies (post-2010) (amiodarone)
1,1431978338,1567431,889

Protein Interaction Comparison

ProteinTaxonomyivabradine (IC50)amiodarone (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.27
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.085
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.404
Bile salt export pumpHomo sapiens (human)10
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)9.148
Tyrosine-protein kinase FynHomo sapiens (human)0.817
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.271
Muscarinic acetylcholine receptor M2Homo sapiens (human)5.08
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.63
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.499
Alpha-2A adrenergic receptorHomo sapiens (human)0.312
Thyroid hormone receptor alphaHomo sapiens (human)0.65
Thyroid hormone receptor betaHomo sapiens (human)0.6
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.613
Lethal factorBacillus anthracis3.5
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.201
D(1A) dopamine receptorHomo sapiens (human)9.142
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.271
5-hydroxytryptamine receptor 2AHomo sapiens (human)3.59
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.404
Sodium-dependent serotonin transporterHomo sapiens (human)2.305
Melanocortin receptor 5Homo sapiens (human)9.497
D(3) dopamine receptorHomo sapiens (human)1.208
Sodium channel protein type 1 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 4 subunit alphaHomo sapiens (human)4.8
Squalene synthaseHomo sapiens (human)8
Delta-type opioid receptorHomo sapiens (human)8.014
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.923
Sodium channel protein type 7 subunit alphaHomo sapiens (human)4.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.085
Sodium-dependent dopamine transporter Homo sapiens (human)2.505
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)6.206
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.085
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.085
Sodium channel protein type 5 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 9 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 2 subunit alphaHomo sapiens (human)4.8
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.097
Sodium channel protein type 3 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 11 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 8 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 10 subunit alphaHomo sapiens (human)4.8

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
DiMarco, JP; Mason, PK1
Drożdż, J; Filipiak, KJ; Grajek, S; Kasprzak, JD; Opolski, G; Rynkiewicz, A; Stępińska, J; Tykarski, A; Wożakowska Kapłon, B1
Belardinelli, L; Machado, AD; Nearing, BD; Sobrado, LF; Varone, BB; Verrier, RL; Zeng, D1
Belardinelli, L; Kanas, AF; Machado, AD; Nearing, BD; Pagotto, VP; Sobrado, LF; Sobrado, MF; Varone, BB; Verrier, RL; Zeng, D1
Dieks, JK; Klehs, S; Krause, U; Müller, MJ; Paul, T1
Hensey, M; O'Neill, J1
Arvind, B; Chowdhury, UK; Devagourou, V; Gupta, SK; Hote, MP; Juneja, R; Kothari, SS; Rajashekar, P; Ramakrishnan, S; Sahu, MK; Saxena, A; Singh, SP; Talwar, S1
Bertero, A; Cain, K; Dupras, S; El-Nachef, D; Futakuchi-Tsuchida, A; Jayabalu, A; Kalucki, FA; Kattman, S; Knollmann, BC; MacLellan, WR; Marchianò, S; Murry, CE; Nakamura, DS; Nakamura, K; Neidig, LE; Pabon, L; Reinecke, H; Robinson, MR; Thies, RS; Tian, R; Tsuchida, H; Weber, GJ; Whittington, D; Yang, X1

Reviews

2 review(s) available for ivabradine and amiodarone

ArticleYear
New pharmacological agents for arrhythmias.
    Circulation. Arrhythmia and electrophysiology, 2009, Volume: 2, Issue:5

    Topics: Acetanilides; Adenosine A1 Receptor Agonists; Amiodarone; Anisoles; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Benzofurans; Clinical Trials as Topic; Dronedarone; Humans; Ivabradine; Piperazines; Pyrrolidines; Ranolazine

2009
Is Heart Rate a Norepiphenomenon in Heart Failure?
    Current cardiology reports, 2016, Volume: 18, Issue:9

    Topics: Adrenergic Antagonists; Amiodarone; Benzazepines; Depression, Chemical; Digoxin; Evidence-Based Medicine; Heart Failure; Heart Rate; Humans; Ivabradine

2016

Trials

1 trial(s) available for ivabradine and amiodarone

ArticleYear
Ivabradine Versus Amiodarone in the Management of Postoperative Junctional Ectopic Tachycardia: A Randomized, Open-Label, Noninferiority Study.
    JACC. Clinical electrophysiology, 2021, Volume: 7, Issue:8

    Topics: Adolescent; Amiodarone; Cardiac Surgical Procedures; Child; Humans; Ivabradine; Postoperative Complications; Tachycardia, Ectopic Junctional

2021

Other Studies

5 other study(ies) available for ivabradine and amiodarone

ArticleYear
[Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].
    Kardiologia polska, 2012, Volume: 70, Issue:10

    Topics: Adrenergic beta-Agonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Digoxin; Diltiazem; Heart Diseases; Heart Rate; Humans; Hypertension; Ivabradine; Verapamil

2012
Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.
    Journal of cardiovascular electrophysiology, 2013, Volume: 24, Issue:8

    Topics: Amiodarone; Analysis of Variance; Animals; Arterial Pressure; Benzazepines; Blood Pressure; Bradycardia; Diltiazem; Dronedarone; Isoproterenol; Ivabradine; Myocardial Contraction; Swine

2013
Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.
    Heart rhythm, 2013, Volume: 10, Issue:11

    Topics: Amiodarone; Animals; Atrial Fibrillation; Atrioventricular Node; Benzazepines; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dronedarone; Drug Therapy, Combination; Electrocardiography; Heart Rate; Heart Ventricles; Ivabradine; Male; Swine; Ventricular Function, Left

2013
Adjunctive ivabradine in combination with amiodarone: A novel therapy for pediatric congenital junctional ectopic tachycardia.
    Heart rhythm, 2016, Volume: 13, Issue:6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Benzazepines; Child, Preschool; Drug Therapy, Combination; Electrocardiography; Electrocardiography, Ambulatory; Female; Germany; Heart Rate; Humans; Infant; Infant, Newborn; Ivabradine; Male; Tachycardia, Ectopic Junctional; Treatment Outcome

2016
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes.
    Stem cell reports, 2021, 10-12, Volume: 16, Issue:10

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Line; Cell- and Tissue-Based Therapy; Disease Models, Animal; Drug Combinations; Humans; Ivabradine; Male; Myocardial Infarction; Myocytes, Cardiac; Pluripotent Stem Cells; Stem Cell Transplantation; Swine; Tachycardia

2021