itraconazole and tacrolimus

itraconazole has been researched along with tacrolimus in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (14.58)	18.2507
2000's	19 (39.58)	29.6817
2010's	17 (35.42)	24.3611
2020's	5 (10.42)	2.80

Authors

Authors	Studies
Adibzadeh, M; Friccius, H; Pawelec, G; Pohla, H; Schenk, A; Siegels-Hübenthal, P	1
Demetris, AJ; Gritsch, A; Jordan, M; Katari, SR; Magnone, M; McCauley, J; Randhawa, PS; Scantlebury, V; Shapiro, R; Starzl, T; Vivas, C	1
Bar, I; Bublil, M; Kramer, MR; Merin, G; Milgalter, E; Nesher, T; Rudis, E	1
Cerrina, J; Dartevelle, P; Furlan, V; Ladurie, FL; Parquin, F; Penaud, JF; Taburet, AM	1
Billaud, EM; Chevalier, P; Guillemain, R; Tacco, F	1
Hossain, MA; Kohno, S; Maesaki, S; Marichal, P; Sanglard, D; Vanden Bossche, H	1
Basile, V; Capone, D; Gentile, A; Imperatore, P; Palmiero, G	1
Hurtado, JL; Martín, I; Outeda Macías, M; Salvador, P	1
Higuchi, M; Hora, K; Ideura, T; Kiyosawa, K; Muramatsu, T; Tachibana, N	1
Friedman, GS; Mathis, AS	1
Benito, N; Moreno, A; Puig, J; Rimola, A	1
Cervelli, MJ; Russ, GR	1
Boyle, GJ; Gandhi, S; Kurland, G; Law, YM; Mahnke, CB; Michaels, M; Miller, SA; Pigula, FA; Sutton, RM; Venkataramanan, R; Webber, SA	1
Hasegawa, A; Kano, R; Okabayashi, K; Ozawa, H; Watanabe, S	1
Bakal, I; Kramer, MR; Ollech, A; Ollech, JE; Sahar, G; Saute, M; Shitrit, D	1
Boyette, RM; Leather, H; Tian, L; Wingard, JR	1
Andrew, S; Fitzgerald, D; Singh, MN	1
Gentry, LO; Hamill, RJ; Koo, HL	1
Arima, F; Eto, T; Gondo, H; Kamo, M; Kato, K; Muta, T; Nawata, R; Okeda, A; Oku, S; Shibuya, T; Takase, K	1
Amrein, C; Benammar, M; Berge, M; Billaud, EM; Boussaud, V; Chevalier, P; Guillemain, R; Lefeuvre, S	1
Dannaoui, E; Lortholary, O; Schwarz, P	1
Aisa, Y; Ikeda, Y; Kato, J; Mori, T; Nakamura, Y; Okamoto, S	1
Aisa, Y; Kato, J; Mori, T; Nakamura, Y; Okamoto, S; Shimizu, T	1
Kagaya, H; Miura, M; Nara, M; Saitoh, H; Sawada, K; Takahashi, N	1
Aomori, T; Araki, T; Fujita, Y; Hiromura, K; Nakamura, T; Nojima, Y; Okada, Y; Shimizu, R; Tomizawa, T; Yamamoto, K	1
Fujishima, N; Hirokawa, M; Kagaya, H; Kameoka, Y; Miura, M; Nara, M; Niioka, T; Saitoh, H; Sawada, K; Tagawa, H; Takahashi, N	1
Kontoyiannis, DP; Shirazi, F	1
Enderby, CY; Heckman, MG; Keller, CA; Thomas, CS	1
Cao, C; Li, X; Liang, H; Mo, D; Sun, C; Wei, L	1
Abumiya, M; Komatsuda, A; Miura, M; Nara, M; Niioka, T; Okuyama, S; Omokawa, A; Takahashi, N; Togashi, M; Wakui, H	1
Bi, KS; Chen, XH; Lu, XF; Zhan, J; Zhou, Y	1
Akashi, K; Ikesue, H; Masuda, S; Matsukawa, K; Miyamoto, T; Shiratsuchi, M; Suetsugu, K; Tsuchiya, Y; Uchida, M; Watanabe, H; Yamamoto-Taguchi, N	1
Gao, L; He, C; Li, M; Sun, Y; Zeng, T	1
Annaert, P; de Hoon, J; de Loor, H; Knops, N; Kuypers, DRJ; Vanhove, T	1
He, Y; Tan, J; Yang, L; Zhang, J	1
Chen-Yoshikawa, TF; Date, H; Imai, S; Masuda, S; Matsubara, K; Matsuda, Y; Nagao, M; Nakagawa, S; Nakagawa, T; Omura, T; Sugimoto, M; Tsuda, M; Tsuzuki, T; Yamamoto, T; Yano, I; Yonezawa, A	1
Hayashi, N; Hirama, T; Kikuchi, M; Kumondai, M; Maekawa, M; Mano, N; Mizuguchi, A; Okada, Y; Sato, T; Sato, Y; Ui, M	1
Abdorahimi, M; Ahmadikia, K; Badali, H; Gharehbolagh, SA; Khodavaisy, S; Mahmoudi, S; Meis, JF; Rezaie, S	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Cannon, RD; Holmes, AR; Lamping, E; Nakamura, K; Niimi, K; Niimi, M; Ranchod, A; Tyndall, JD	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1

Reviews

4 review(s) available for itraconazole and tacrolimus

Article	Year
Coadministration of digoxin with itraconazole in renal transplant recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:2 Topics: Anti-Arrhythmia Agents; Antifungal Agents; Atrial Fibrillation; Digoxin; Drug Interactions; Humans; Immunosuppressive Agents; Itraconazole; Kidney Transplantation; Male; Middle Aged; Tacrolimus	2001
Alternariosis after liver transplantation. Transplantation, 2001, Dec-15, Volume: 72, Issue:11 Topics: Alternaria; Antifungal Agents; Humans; Immunosuppressive Agents; Itraconazole; Liver Transplantation; Male; Middle Aged; Mycoses; Tacrolimus	2001
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022

Trials

5 trial(s) available for itraconazole and tacrolimus

Article	Year
Itraconazole prophylaxis in lung transplant recipients receiving tacrolimus (FK 506): efficacy and drug interaction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2005, Volume: 24, Issue:12 Topics: Antifungal Agents; Drug Costs; Drug Interactions; Drug Therapy, Combination; Graft Rejection; Humans; Immunosuppressive Agents; Itraconazole; Kidney; Lung Transplantation; Mycoses; Postoperative Complications; Tacrolimus	2005
Pharmacokinetic evaluation of the drug interaction between intravenous itraconazole and intravenous tacrolimus or intravenous cyclosporin A in allogeneic hematopoietic stem cell transplant recipients. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:3 Topics: Adult; Antifungal Agents; Cyclosporine; Drug Interactions; Drug Monitoring; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Injections, Intravenous; Itraconazole; Male; Middle Aged; Prospective Studies; Tacrolimus; Transplantation, Homologous	2006
The consequences of tacrolimus blood concentrations during the four weeks following marrow transplantation from an unrelated donor: a single-center experience. Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:1 Topics: Adolescent; Adult; Aged; Bone Marrow Transplantation; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Female; Graft vs Host Disease; Humans; Itraconazole; Male; Middle Aged; Survival Rate; Tacrolimus; Time Factors; Tissue Donors; Transplantation, Homologous	2008
Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants. European journal of clinical pharmacology, 2013, Volume: 69, Issue:6 Topics: Administration, Oral; Adult; Antifungal Agents; Asian People; Chi-Square Distribution; Cyclosporine; Cytochrome P-450 CYP3A; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Genotype; Humans; Immunosuppressive Agents; Itraconazole; Japan; Male; Middle Aged; Pharmacogenetics; Phenotype; Pilot Projects; Polymorphism, Genetic; Prospective Studies; Stem Cell Transplantation; Tacrolimus; Transplantation, Homologous	2013
In vivo CYP3A4 activity does not predict the magnitude of interaction between itraconazole and tacrolimus from an extended release formulation. Basic & clinical pharmacology & toxicology, 2019, Volume: 124, Issue:1 Topics: Administration, Oral; Adult; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Delayed-Action Preparations; Drug Interactions; Healthy Volunteers; Humans; Itraconazole; Male; Metabolic Clearance Rate; Midazolam; Prospective Studies; Tacrolimus; Young Adult	2019

Other Studies

39 other study(ies) available for itraconazole and tacrolimus

Article	Year
The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. International journal of immunopharmacology, 1992, Volume: 14, Issue:5 Topics: Antifungal Agents; Cells, Cultured; Cyclosporine; Cytokines; Fluconazole; Gene Expression; Humans; Itraconazole; Ketoconazole; Lymphocytes; Miconazole; Tacrolimus	1992
Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. Clinical transplantation, 1997, Volume: 11, Issue:3 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Antifungal Agents; Biopsy, Needle; Clarithromycin; Creatinine; Diltiazem; Drug Interactions; Female; Humans; Hyperglycemia; Hyperkalemia; Hypertension; Immunosuppressive Agents; Infusions, Intravenous; Itraconazole; Kidney; Kidney Transplantation; Male; Middle Aged; Tacrolimus; Time Factors; Transplantation, Homologous; Tremor; Ultrasonography; Vasodilator Agents	1997
Dose adjustment and cost of itraconazole prophylaxis in lung transplant recipients receiving cyclosporine and tacrolimus (FK 506). Transplantation proceedings, 1997, Volume: 29, Issue:6 Topics: Antifungal Agents; Costs and Cost Analysis; Cyclosporine; Female; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Itraconazole; Lung Transplantation; Male; Mycoses; Tacrolimus; Transplantation, Homologous	1997
Interaction between tacrolimus and itraconazole in a heart-lung transplant recipient. Transplantation proceedings, 1998, Volume: 30, Issue:1 Topics: Antifungal Agents; Drug Interactions; Female; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Itraconazole; Middle Aged; Tacrolimus	1998
Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. British journal of clinical pharmacology, 1998, Volume: 46, Issue:3 Topics: Adolescent; Antifungal Agents; Drug Interactions; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Itraconazole; Liver Transplantation; Lung Transplantation; Male; Retrospective Studies; Tacrolimus	1998
Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:6 Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Azoles; Candida albicans; Candidiasis, Oral; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Synergism; Fluconazole; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, MDR; Humans; Itraconazole; Membrane Transport Proteins; Microbial Sensitivity Tests; Tacrolimus	1998
Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:10 Topics: Adult; Antifungal Agents; Candidiasis; Drug Interactions; Humans; Immunosuppressive Agents; Itraconazole; Kidney Transplantation; Male; Tacrolimus	1999
Tacrolimus-itraconazole interaction in a kidney transplant patient. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:4 Topics: Adult; Antifungal Agents; Drug Interactions; Female; Humans; Immunosuppressive Agents; Itraconazole; Kidney Transplantation; Tacrolimus	2000
Tacrolimus/itraconazole interactions: a case report of ABO-incompatible living-related renal transplantation. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:10 Topics: ABO Blood-Group System; Adult; Antifungal Agents; Blood Group Incompatibility; Drug Interactions; Humans; Immunosuppressive Agents; Itraconazole; Kidney Transplantation; Living Donors; Male; Tacrolimus	2000
Itraconazole-tacrolimus drug interaction. Therapeutic drug monitoring, 2003, Volume: 25, Issue:4 Topics: Adult; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Humans; Immunosuppressive Agents; Itraconazole; Kidney Transplantation; Male; Pancreas Transplantation; Tacrolimus; Time Factors	2003
Tacrolimus dosage requirements after initiation of azole antifungal therapy in pediatric thoracic organ transplantation. Pediatric transplantation, 2003, Volume: 7, Issue:6 Topics: Analysis of Variance; Antifungal Agents; Child; Female; Fluconazole; Humans; Immunosuppressive Agents; Itraconazole; Male; Mycoses; Organ Transplantation; Retrospective Studies; Tacrolimus	2003
Antifungal activities of the combination of tacrolimus and itraconazole against Trichophyton mentagrophytes. The Journal of veterinary medical science, 2005, Volume: 67, Issue:6 Topics: Antifungal Agents; Colony Count, Microbial; Drug Synergism; Itraconazole; Microbial Sensitivity Tests; Tacrolimus; Trichophyton	2005
Solitary cutaneous nodule in an immunocompromised patient. Archives of dermatology, 2007, Volume: 143, Issue:12 Topics: Alternaria; Ankle; Dermatomycoses; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Itraconazole; Kidney Transplantation; Middle Aged; Pyrimidines; Retreatment; Tacrolimus; Triazoles; Voriconazole	2007
Disseminated histoplasmosis manifesting as a soft-tissue chest wall mass in a heart transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society, 2008, Volume: 10, Issue:5 Topics: Aged; Amphotericin B; Antifungal Agents; Biopsy; Debridement; Diagnosis, Differential; Drug Administration Schedule; Drug Therapy, Combination; Graft Rejection; Heart Transplantation; Histoplasma; Histoplasmosis; Humans; Immunosuppressive Agents; Itraconazole; Male; Mycophenolic Acid; Soft Tissue Infections; Tacrolimus; Thoracic Wall; Tomography, X-Ray Computed; Transplantation Conditioning	2008
Safe management of tacrolimus together with posaconazole in lung transplant patients with cystic fibrosis. Therapeutic drug monitoring, 2009, Volume: 31, Issue:3 Topics: Adult; Antifungal Agents; Aspergillosis; Candidiasis; Cystic Fibrosis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Female; Graft Rejection; Humans; Immunosuppressive Agents; Itraconazole; Lung Transplantation; Male; Microbial Sensitivity Tests; Mycoses; Prescriptions; Pyrimidines; Tacrolimus; Triazoles; Voriconazole	2009
In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8 Topics: Amphotericin B; Antifungal Agents; Azoles; Cyclosporine; Drug Interactions; Immunosuppressive Agents; Itraconazole; Microbial Sensitivity Tests; Mucorales; Rhizopus; Sirolimus; Tacrolimus; Thiazoles; Triazoles	2009
Drug interaction between oral solution itraconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplantation recipients: an association with bioavailability of oral solution itraconazole. International journal of hematology, 2009, Volume: 90, Issue:1 Topics: Administration, Oral; Antifungal Agents; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Drug Interactions; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Itraconazole; Male; Retrospective Studies; Tacrolimus; Transplantation, Homologous	2009
Overcoming the effect of rifampin on the tacrolimus metabolism by itraconazole administration in an allogeneic hematopoietic stem cell transplant recipient. International journal of hematology, 2010, Volume: 91, Issue:3 Topics: Antibiotics, Antitubercular; Antifungal Agents; Drug Interactions; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Itraconazole; Middle Aged; Myelodysplastic Syndromes; Rifampin; Tacrolimus; Transplantation, Homologous	2010
Effect of oral itraconazole on the pharmacokinetics of tacrolimus in a hematopoietic stem cell transplant recipient with CYP3A53/3. American journal of hematology, 2010, Volume: 85, Issue:8 Topics: Administration, Oral; Alleles; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Capsules; Combined Modality Therapy; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dacarbazine; Doxorubicin; Drug Interactions; Drug Therapy, Combination; Female; Genotype; Graft vs Host Disease; Half-Life; Hodgkin Disease; Humans; Immunosuppressive Agents; Infusions, Intravenous; Intestines; Itraconazole; Methotrexate; Tacrolimus; Transplantation, Homologous; Vinblastine; Young Adult	2010
Analysis of cytochrome P450 gene polymorphism in a lupus nephritis patient in whom tacrolimus blood concentration was markedly elevated after administration of azole antifungal agents. Journal of clinical pharmacy and therapeutics, 2013, Volume: 38, Issue:1 Topics: Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Female; Genotype; Humans; Immunosuppressive Agents; Itraconazole; Lupus Nephritis; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Pyrimidines; Tacrolimus; Triazoles; Voriconazole	2013
The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against Mucorales via apoptosis. Eukaryotic cell, 2013, Volume: 12, Issue:9 Topics: Antifungal Agents; Apoptosis; Calcineurin Inhibitors; Dose-Response Relationship, Drug; Itraconazole; Mucorales; Tacrolimus; Triazoles	2013
Tacrolimus dosage requirements in lung transplant recipients receiving antifungal prophylaxis with voriconazole followed by itraconazole: a preliminary prospective study. Clinical transplantation, 2014, Volume: 28, Issue:8 Topics: Adult; Aged; Antibiotic Prophylaxis; Antifungal Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Itraconazole; Lung Transplantation; Male; Middle Aged; Mycoses; Postoperative Complications; Prognosis; Prospective Studies; Tacrolimus; Voriconazole	2014
In vitro interactions of calcineurin inhibitors with conventional antifungal agents against the yeast form of Penicillium marneffei. Mycopathologia, 2014, Volume: 178, Issue:3-4 Topics: Antifungal Agents; Calcineurin Inhibitors; Cyclosporine; Drug Synergism; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Penicillium; Tacrolimus; Yeasts	2014
Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease. European journal of clinical pharmacology, 2015, Volume: 71, Issue:9 Topics: Adolescent; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B; Connective Tissue Diseases; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Genotype; Humans; Immunosuppressive Agents; Itraconazole; Male; Middle Aged; Polymorphism, Single Nucleotide; Tacrolimus; Young Adult	2015
Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:9 Topics: Animals; Antifungal Agents; Drug Interactions; Immunosuppressive Agents; Itraconazole; Mice; Models, Biological; Random Allocation; Tacrolimus	2017
Analysis of the variable factors influencing tacrolimus blood concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. International journal of hematology, 2017, Volume: 105, Issue:3 Topics: Administration, Oral; Adult; Aged; Allografts; Drug Therapy, Combination; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Infusions, Intravenous; Itraconazole; Male; Middle Aged; Retrospective Studies; Tacrolimus; Voriconazole	2017
Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12 Topics: Antifungal Agents; Biofilms; Calcineurin Inhibitors; Candida parapsilosis; Drug Synergism; Exophiala; Humans; Itraconazole; Microbial Sensitivity Tests; Phaeohyphomycosis; Tacrolimus; Triazoles; Voriconazole	2017
Tacrolimus, not triamcinolone acetonide, interacts synergistically with itraconazole, terbinafine, bifonazole, and amorolfine against clinical dermatophyte isolates. Journal de mycologie medicale, 2018, Volume: 28, Issue:4 Topics: Antifungal Agents; Arthrodermataceae; Dermatomycoses; Drug Synergism; Humans; Imidazoles; Immunosuppressive Agents; Itraconazole; Microbial Sensitivity Tests; Morpholines; Species Specificity; Tacrolimus; Terbinafine; Triamcinolone Acetonide	2018
Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients. Biological & pharmaceutical bulletin, 2022, Volume: 45, Issue:4 Topics: Cyclosporine; Humans; Itraconazole; Lung; Retrospective Studies; Tacrolimus; Transplant Recipients	2022
Therapeutic Drug Monitoring of Blood Sirolimus and Tacrolimus Concentrations for Polypharmacy Management in a Lymphangioleiomyomatosis Patient Taking Two Cytochrome P450 3A Inhibitors. The Tohoku journal of experimental medicine, 2023, May-13, Volume: 260, Issue:1 Topics: Clarithromycin; Cytochrome P-450 CYP3A; Drug Monitoring; Female; Humans; Immunosuppressive Agents; Itraconazole; Lymphangioleiomyomatosis; Middle Aged; Mycophenolic Acid; Polypharmacy; Prednisolone; Sirolimus; Tacrolimus	2023
In vitro combination of antifungal drugs with tacrolimus (FK506) holds promise against clinical Candida species, including Candida auris. Medical mycology, 2023, Jul-06, Volume: 61, Issue:7 Topics: Anidulafungin; Animals; Antifungal Agents; Candida; Candida auris; Candida glabrata; Candida parapsilosis; Caspofungin; Echinocandins; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Tacrolimus	2023
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Amino Acid Sequence; Animals; Antifungal Agents; ATP-Binding Cassette Transporters; Azoles; Blotting, Northern; Blotting, Southern; Candida; Candidiasis; Cell Membrane; Chromosomes, Fungal; Drug Resistance, Fungal; Endoplasmic Reticulum; Humans; Phenotype; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023