Compounds > itraconazole

itraconazole and lanosterol

itraconazole has been researched along with lanosterol in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's3 (27.27)18.2507
2000's1 (9.09)29.6817
2010's5 (45.45)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Rippon, JW1
Coene, MC; Cools, W; Gorrens, J; Le Jeune, L; Marichal, P; Vanden Bossche, H1
Barbuch, R; Bard, M; Gachotte, D; Koegel, C; Lees, ND; Pierson, CA1
Casali, AK; Hamdan, JS1
Kelly, DE; Kelly, SL; Martel, CM; Melo, N; Nes, WD; Parker, JE; Warrilow, AG1
Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG1
Garvey, EP; Hoekstra, WJ; Kelly, DE; Kelly, SL; Nes, WD; Parker, JE; Price, CL; Schotzinger, RJ; Warrilow, AG1
Keniya, MV; Monk, BC; Ruma, YN; Tyndall, JDA1
Keniya, MV; Monk, BC; Sabherwal, M; Sagatova, AA; Tyndall, JDA; Wilson, RK; Woods, MA1
Ekins, S; Harwood, HJ; Hoover, DJ; Lawton, MP; Mankowski, DC; Treadway, JL1
Guengerich, FP; Hargrove, TY; Lepesheva, GI; Nes, WD; Rachakonda, G; Villalta, F; Wawrzak, Z1

Other Studies

11 other study(ies) available for itraconazole and lanosterol

ArticleYear
A new era in antimycotic agents.
    Archives of dermatology, 1986, Volume: 122, Issue:4

    Topics: Animals; Antifungal Agents; Azoles; Candida albicans; Chitin; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Dogs; Ergosterol; Fungi; Humans; Itraconazole; Ketoconazole; Lanosterol; Liver; Rats; Sterols

1986
Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10

    Topics: Cryptococcus neoformans; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ergosterol; Itraconazole; Ketosteroids; Lanosterol; Methylation; Oxidation-Reduction; Sterols

1993
A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Oct-14, Volume: 94, Issue:21

    Topics: Antifungal Agents; Azoles; Clotrimazole; Genes, Fungal; Genotype; Heme; Itraconazole; Ketoconazole; Lanosterol; Mixed Function Oxygenases; Mutation; Saccharomyces cerevisiae; Sterols; Suppression, Genetic

1997
Effects of three azole derivatives on the lipids of different strains of Sporothrix schenckii.
    Canadian journal of microbiology, 1997, Volume: 43, Issue:12

    Topics: Antifungal Agents; Fluconazole; Itraconazole; Ketoconazole; Lanosterol; Lipids; Sporothrix

1997
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Amino Acid Sequence; Aspergillus fumigatus; Azoles; Clotrimazole; Drug Resistance, Multiple, Fungal; Fluconazole; Fungal Proteins; Isoenzymes; Itraconazole; Lanosterol; Molecular Sequence Data; Protein Binding; Pyrimidines; Sequence Homology, Amino Acid; Sterol 14-Demethylase; Substrate Specificity; Triazoles; Voriconazole

2010
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:3

    Topics: Antifungal Agents; Candida albicans; Clotrimazole; Escherichia coli; Fluconazole; Fungal Proteins; Humans; Itraconazole; Ketoconazole; Kinetics; Lanosterol; NADP; Protein Binding; Pyrimidines; Recombinant Proteins; Species Specificity; Sterol 14-Demethylase; Triazoles; Voriconazole

2013
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8

    Topics: Antifungal Agents; Clotrimazole; Cryptococcus; Enzyme Activation; Ergosterol; Fluconazole; Humans; Itraconazole; Ketoconazole; Lanosterol; Pyridines; Sterol 14-Demethylase; Tetrazoles; Voriconazole

2016
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:11

    Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles; Voriconazole

2018
Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:11

    Topics: Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Catalytic Domain; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Protein Binding; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles

2018
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3

    Topics: Amides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Oxidoreductases; Quantitative Structure-Activity Relationship; Sterol 14-Demethylase

2007
Relaxed Substrate Requirements of Sterol 14α-Demethylase from
    Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23

    Topics: 14-alpha Demethylase Inhibitors; Ligands; Naegleria fowleri; Sterol 14-Demethylase; Substrate Specificity

2021