Compounds > itaconic acid

itaconic acid and cysteine

itaconic acid has been researched along with cysteine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (55.56)24.3611
2020's4 (44.44)2.80

Authors

AuthorsStudies
Moynihan, MM; Murkin, AS1
Ashford, MLJ; Booty, LM; Brunori, G; Caldwell, ST; Carroll, RG; Chouchani, ET; Costa, ASH; Dikovskaya, D; Dinkova-Kostova, AT; Fallon, PG; Fischer, R; Frezza, C; Hams, E; Hartley, RC; Higgins, M; Hughes, MM; Jedrychowski, MP; Kessler, BM; King, MS; Knatko, EV; Kunji, ERS; McGettrick, AF; McGouran, JF; Meakin, PJ; Menon, D; Mills, EL; Modis, LK; Murphy, MP; O'Neill, LA; Prag, HA; Runtsch, MC; Ryan, DG; Sévin, DC; Szpyt, J; Zaslona, Z1
Chen, N; Chen, X; Chen, Y; Cheng, B; Jia, W; Liu, Y; Peng, L; Qin, K; Qin, W; Wang, C; Wang, YL; Zhang, Y; Zhou, W1
Yang, J1
Fu, XW; Han, C; Kong, LY; Liao, ST; Wang, JS; Xu, DQ1
Chen, Y; Liu, D; Liu, Y; Qin, W; Tang, H; Wang, C; Zhang, Y1
Li, G; Li, X; Liang, X; Liu, X; Shi, B; Suo, R; Wang, X; Xiong, S1
Fling, RR; Nault, R; Orlowska, K; Schilmiller, AL; Sink, WJ; Zacharewski, T1
Console, L; Giangregorio, N; Indiveri, C; Scalise, M; Tonazzi, A1

Other Studies

9 other study(ies) available for itaconic acid and cysteine

ArticleYear
Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate.
    Biochemistry, 2014, Jan-14, Volume: 53, Issue:1

    Topics: Catalysis; Cysteine; Deuterium Oxide; Hydrogen-Ion Concentration; Isocitrate Lyase; Kinetics; Mycobacterium tuberculosis; Nitro Compounds; Propionates; Solvents; Succinates

2014
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
    Nature, 2018, 04-05, Volume: 556, Issue:7699

    Topics: Alkylation; Animals; Anti-Inflammatory Agents; Carboxy-Lyases; Cattle; Cysteine; Cytokines; Feedback, Physiological; Female; HEK293 Cells; Humans; Hydro-Lyases; Interferon-beta; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; Macrophages; Mice; NF-E2-Related Factor 2; Proteins; Rats; Rats, Wistar; Succinates

2018
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate.
    Nature chemical biology, 2019, Volume: 15, Issue:10

    Topics: Animals; Cysteine; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Glycolysis; Glycosylation; HeLa Cells; Humans; Inflammation; MCF-7 Cells; Mice; Proteome; RAW 264.7 Cells; Succinates

2019
Sweetly profiling the cysteinome.
    Nature chemical biology, 2019, Volume: 15, Issue:10

    Topics: Carbohydrates; Cysteine; Humans; Inflammation; Macrophages; Proteins; Succinates

2019
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
    Nature communications, 2019, 11-08, Volume: 10, Issue:1

    Topics: Alkylation; Animals; Antimetabolites; Cysteine; Deoxyglucose; Down-Regulation; Endotoxemia; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase Type II; Oxidative Phosphorylation; RAW 264.7 Cells; Sesquiterpenes; Succinates

2019
Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages.
    Journal of the American Chemical Society, 2020, 06-24, Volume: 142, Issue:25

    Topics: A549 Cells; Alkynes; Animals; Anti-Inflammatory Agents; Cysteine; Glutathione; Humans; Macrophages; Mice; Molecular Probes; Proteins; Proteomics; RAW 264.7 Cells; Succinates

2020
Itaconate regulates macrophage function through stressful iron-sulfur cluster disrupting and iron metabolism rebalancing.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10

    Topics: Aconitate Hydratase; Carboxy-Lyases; Cell Line; Cysteine; Cytokines; Humans; Inflammasomes; Interleukin-1beta; Iron; Macrophages; NLR Family, Pyrin Domain-Containing 3 Protein; Proteome; Proteomics; Succinates; Sulfur

2021
Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate buildup.
    The Journal of biological chemistry, 2022, Volume: 298, Issue:9

    Topics: Aconitic Acid; Acyl Coenzyme A; Animals; Cobalt; Cysteine; Environmental Pollutants; Fatty Liver; Humans; Liver; Methylmalonyl-CoA Mutase; Mice; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Succinates; Vitamin B 12; Vitamin B 12 Deficiency

2022
Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications.
    Biomolecules, 2023, 06-15, Volume: 13, Issue:6

    Topics: Carnitine; Cysteine; HeLa Cells; Humans; Membrane Transport Modulators; Membrane Transport Proteins; Mitochondria

2023