isradipine has been researched along with oxadiazoles in 214 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 149 (69.63) | 18.7374 |
| 1990's | 65 (30.37) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Glossmann, H; Knaus, HG; Staudinger, R | 1 |
| Ellis, M; Jensen, RA; Keung, EC; Toll, L | 1 |
| Bladen, C; Dunn, SM | 1 |
| Galletti, F; Krogh, V; Rutledge, A; Triggle, DJ | 1 |
| Corcuff, JB; Guérineau, N; Mollard, P; Tabarin, A | 1 |
| Gollasch, M; Hescheler, J; Klinz, FJ; Rosenthal, W; Schultz, G; Spicher, K | 1 |
| Hu, SL; Jeng, AY; Kim, HS | 1 |
| Bazan, E; Johnson, CL; Schwartz, A; Sole, MJ | 1 |
| Bangalore, R; Hawthorn, M; Triggle, DJ | 1 |
| Araki, T; Hara, H; Kato, H; Kogure, K; Onodera, H | 1 |
| Keith, RA; Moore, WC; Patel, J; Salama, AI | 1 |
| Little, HJ; Littleton, JM; Whittington, MA | 1 |
| Battaini, F; Bergamaschi, S; Govoni, S; Meucci, O; Parenti, M; Schettini, G; Trabucchi, M | 1 |
| Levine, JH; Snowman, AM; Snyder, SH; Wagner, JA; Weisman, HF | 1 |
| Creazzo, TL | 1 |
| Fraser, S; Kenny, BA; Kilpatrick, AT; Spedding, M | 1 |
| Naitoh, T; Sugimoto, T; Toyo-Oka, T | 1 |
| Lepor, H; Rosenthal, E; Shapiro, E | 1 |
| Abraham, C; Aptel, H; Lombet, A; Nagel, N; Peglion, JL; Randle, JC; Renaud, JF | 1 |
| Gu, XH; Nayler, WG | 1 |
| Lory, P; Schultz, D; Schwartz, A; Varadi, G; Varadi, M | 1 |
| Henstenberg, JD; Sharp, GW; Stafford, GA; Weiland, GA; Yaney, GC | 1 |
| Collins, F; Guthrie, PB; Kater, SB; Schmidt, MF | 1 |
| Drimal, J | 1 |
| Cheung, JY; Elensky, M; Misawa, H; Moore, RL; Pawlush, DG; Scaduto, RC; Yelamarty, RV | 1 |
| Fratta, W; Gessa, GL; Kuzmin, A; Martellotta, MC; Pani, L | 1 |
| Balkan, A; Ertan, M; Renaud, JF; Rollad, Y; Saraç, S; Uma, S | 1 |
| Marinov, M; Wassmann, H | 1 |
| Bezáková, G; Krizanová, O; Lehotský, J; Mézesová, V | 1 |
| Little, HJ; Whittington, MA | 1 |
| Karpova, MN; Kryzhanovskiĭ, GN; Pankov, OIu | 1 |
| Fujimoto, M; Mihara, S | 1 |
| Ebata, H; Mitsuhashi, T; Natsume, T; Yaginuma, T | 1 |
| Bevilacqua, M; Norbiato, G; Vago, T | 1 |
| Murphy, BJ; Tuana, BS | 1 |
| Pinchuk, GV; Pinchuk, LN; Rudenko, AE; Tkachenko, YV | 1 |
| Brodie, C; Sampson, SR | 1 |
| Gopalakrishnan, M; Triggle, DJ | 1 |
| Rampe, D; Schilling, WP; Zaher, MC | 1 |
| Bai-Grenier, F; Birman, P; Dubray, C; Joubert, D; Peillon, F; Touraine, P | 1 |
| Kogure, K; Onodera, H | 1 |
| Edwards, WD; Lefler, BJ; Natale, NR; Palmer, RB; Triggle, DJ | 1 |
| Asahina, T; Ikebuchi, M; Kashiwagi, A; Kodama, M; Nishio, Y; Ogawa, T; Shigeta, Y | 1 |
| Farrell, AP; Kashihara, H; Keen, JE; Thomas, MJ; Tibbits, GF | 1 |
| Beaufort, P; Chatelain, P; Clinet, M; Laruel, R; Meysmans, L; Nokin, P | 1 |
| Galletti, F; Luchowski, E; Triggle, DJ | 1 |
| Ebata, H; Johnson, JD; Mills, JS; Nemcek, K | 1 |
| Harada, Y; Kimura, R; Nakayama, K; Yamada, S | 1 |
| Lemaire, S; Murphy, BJ; Rogers, CA; Sunahara, RK; Tuana, BS | 1 |
| Bristow, MR; Minobe, W; Rasmussen, RP | 1 |
| Brandt, NR; Brunschwig, JP; Caswell, AH; Kim, KC | 1 |
| Glossmann, H; Knaus, HG; Romanin, C; Scheffauer, F; Schindler, HG | 1 |
| Birnbaumer, L; Brown, AM; Kim, HS; Lacerda, AE; Rampe, D | 1 |
| Messing, RO; Savidge, B; Sneade, AB | 1 |
| Ahlijanian, MK; Catterall, WA; Westenbroek, RE | 1 |
| Baird, JG; Lambert, DG; Nahorski, SR; Whitham, EM | 1 |
| Barradas, J; Gerbeau, C | 1 |
| Couraud, F; Martin-Moutot, N; Seagar, M | 1 |
| Banning, JW; Rao, VR | 1 |
| Eckert, R; Hescheler, J; Krautwurst, D; Schultz, G; Trautwein, W | 1 |
| Cross, AJ; Davies, EM; Green, AR; Little, HJ; Whittington, MA | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Desnuelle, C; Liot, D; Lombet, A; Serratrice, G | 1 |
| Fosset, M; Lazdunski, M; Pinçon-Raymond, M; Rieger, F | 1 |
| Benavides, J; Bertrand, P; Burgevin, MC; Doble, A; Ferris, O; Gueremy, C; Le Fur, G; Menager, J; Uzan, A; Vaucher, N | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Cognard, C; Fosset, M; Galizzi, JP; Lazdunski, M; Romey, G | 1 |
| Catterall, WA; Curtis, BM | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 3 |
| Kendall, DA | 1 |
| Barhanin, J; Borsotto, M; Coppola, T; Lazdunski, M; Mourre, C; Schmid, A | 1 |
| Hosey, MM; Maan, AC; Ptasienski, J | 1 |
| Nahorski, SR; Rooney, TA | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A | 1 |
| Cauvin, C; Hwang, O; van Breemen, C; Yamamoto, M | 1 |
| Heider, JG; Weinstein, DB | 1 |
| Brown, AM; Brush, K; Hamilton, SL; Schwartz, A; Yatani, A | 1 |
| Ferry, DR; Kaumann, AJ | 1 |
| Brown, AM; Hamilton, SL; Hawkes, MJ; Kunze, DL | 1 |
| Fosset, M; Galizzi, JP; Lazdunski, M; Qar, J; Van Renterghem, C | 1 |
| Holck, M; Osterrieder, W | 1 |
| Artalejo, CR; Fonteriz, RI; Gandia, L; García, AG; Lopez, MG | 1 |
| Lee, RT; Marsh, JD; Smith, TW | 1 |
| Broudy, DR; Greenberg, BH; Siemienczuk, D | 1 |
| Hofmann, F; Nastainczyk, W; Sieber, M; Wernet, W; Zubor, V | 1 |
| Froehner, SC; Morton, ME | 1 |
| Askanas, V; Desnuelle, C; Engel, WK | 2 |
| Catterall, WA; Curtis, BM; Ice, KS; Takahashi, M | 1 |
| Johnson, DF; Kuo, TH; Tsang, W; Wiener, J | 1 |
| Abram, A; Baginski, T; Banning, J; Rao, V | 1 |
| DeRoth, L; Godfraind, T; Wibo, M | 1 |
| Brown, AM; Kunze, DL; Yatani, A | 1 |
| Nelson, MT; Talvenheimo, JA; Worley, JF | 1 |
| Battaini, F; Govoni, S; Magnoni, MS; Trabucchi, M | 1 |
| Cook, NS; Quast, U | 1 |
| Lamb, GD; Walsh, T | 1 |
| Kokubun, S; Porzig, H; Prod'hom, B; Reuter, H | 1 |
| Laterre, EC; Maloteaux, JM; Octave, JN | 1 |
| Andrén, L; Aurell, M; Dahlöf, B; Eggertsen, R; Hansson, L; Jern, S; Sievert, A; Svensson, A | 1 |
| Giacomelli, F; Johnson, DF; Kuo, TH; Wiener, J | 1 |
| Krizanová, O; Orlický, J; Zachar, J | 1 |
| Highsmith, RF; Schwartz, A; Whitmer, KR; Williams-Lawson, JS | 1 |
| Becker, C; Porzig, H | 1 |
| Beam, KG; Knudson, CM | 1 |
| Massieu, L; Tapia, R | 1 |
| Dunn, SM | 2 |
| Brisac, AM; Lacolley, P; Laurent, S; Legrand, M; Schmitt, H; Tsoucaris-Kupfer, D | 1 |
| Barhanin, J; Frelin, C; Lazdunski, M; Schmid-Alliana, A; Van Renterghem, C; Vigne, P | 1 |
| Faivre-Bauman, A; Loudes, C; Patte, C; Tixier-Vidal, A | 1 |
| Borges, R; Cárdenas, AM; Esteban, C; García, AG; Montiel, C | 1 |
| Allen, PD; Marsh, JD | 1 |
| Dillon, JS; Gu, XH; Nayler, WG | 2 |
| Callens, F; Charlemagne, D; Mayoux, E; Swynghedauw, B | 1 |
| Cook, NS | 1 |
| Carpenter, CL; Greenberg, DA; Marks, SS; Messing, RO; Watson, DL | 2 |
| Poder, T; Rampe, D; Schilling, WP; Zhao, ZY | 1 |
| Crijns, HJ; Lie, KI; Ruegg, P; van den Toren, WE; van Gelder, I; van Wijk, LM | 1 |
| Akbarali, H; Gilbert, R; Hall, J; Moody-Corbett, F | 1 |
| Buisson, N; Gourdji, D; Laverrière, JN; Martial, JA; Richard, JL; Tixier-Vidal, A | 1 |
| Dacquet, C; Loirand, G; Mironneau, C; Mironneau, J; Rakotoarisoa, L | 1 |
| Aonuma, S; Fujisue, T; Ichida, S; Masada, A; Matsuda, N; Oda, Y | 1 |
| Castillo, CJ; Fonteríz, RI; García, AG; López, MG; Rosenheck, K | 1 |
| Dodd, PR; Gundlach, AL; Harper, CG; Johnston, GA; Kril, JJ | 1 |
| Matlib, MA | 1 |
| Chaumet-Riffaud, PD; Machard, B | 1 |
| Brown, AM; Rampe, D; Skattebøl, A; Triggle, DJ | 1 |
| Coronado, R; Valdivia, HH | 1 |
| Dillon, JS; Gu, XH; Liu, JJ; Nayler, WG | 1 |
| Rutledge, A; Triggle, DJ; Wei, XY | 1 |
| Kanngiesser, U; Pongs, O | 1 |
| Ferrante, J; Rutledge, A; Triggle, DJ; Wei, XY; Zhong, Q | 1 |
| Hudecová, S; Krizanová, O; Orlický, J; Zachar, J | 1 |
| Eglen, RM; Michel, AD; Sharif, NA; Swank, SR; Whiting, RL | 1 |
| Magill, SB; Parmar, SS; Stone, JS | 1 |
| Godfraind, T; Morel, N | 3 |
| Alvarez, RM; Brush, KL; Fill, M; Hamilton, SL; Hawkes, MJ; Schilling, WP; Stefani, E | 1 |
| Glossmann, H; Grassegger, A; Knaus, HG; Striessnig, J; Weiler, M | 1 |
| Greenberg, DA; Jaffe, DB; Marks, SS | 1 |
| Keith, RA; Mangano, TJ; Pacheco, MA; Salama, AI | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Linn, T | 1 |
| Leysen, JE; Pauwels, PJ; Van Assouw, HP | 1 |
| Brown, AM; Caffrey, JM; Rampe, D; Schneider, MD | 1 |
| Bode-Greuel, KM; Singer, W | 1 |
| Becker, R; Glossmann, H; Grabner, M; Henning, R; Kaiser, J; Knaus, HG; Linz, W; Meusburger, E; Schölkens, B; Striessnig, J | 1 |
| Andrawis, NS; Giacomelli, F; Kuo, TH; Wiener, J | 1 |
| Garcia, L; Lazdunski, M; Rieger, F; Romey, G | 1 |
| Kamp, TJ; Miller, RJ; Sanguinetti, MC | 1 |
| Jie, K; Thoolen, MJ; Timmermans, PB; van Brummelen, P; van Zwieten, PA | 1 |
| Hof, RP | 2 |
| Benavides, J; Claustre, Y; Scatton, B | 1 |
| Cook, NS; Hof, RP | 1 |
| Quirion, R | 1 |
| Bossaller, C; Habib, JB; Henry, PD; Morrisett, JD; Wells, S; Williams, C | 1 |
| Al-Mahmood, HA; el-Khatim, MS; Gumaa, KA; Thulesius, O | 1 |
| Handley, DA; Melden, MK; Saunders, RN; Van Valen, RG | 1 |
| Bevan, JA; Hwa, JJ | 1 |
| Allen, J; Jackson, NC; Pool, PE; Taylor, SH | 1 |
| Dahlof, B; Hansson, L | 1 |
| Hamilton, BP | 1 |
| Hof, RP; Salzmann, R; Siegl, H | 1 |
| Broudy, D; Greenberg, B; Siemienczuk, D | 1 |
| Bevan, JA; Bijak, A; McPherson, GA; Pasternac, A | 1 |
| Betjemann, P; Kleinstein, J; Weidacher, A | 1 |
| Golichowski, AM; Tzeng, DY | 1 |
| Evenou, JP; Hof, RP; Hof-Miyashita, A | 1 |
| Gerard, P; Huchet, AM; Huguet, F; Narcisse, G | 1 |
| Jaffe, JM; Tse, FL | 1 |
| del Pozo, E; Sieber, C | 1 |
| Navarro, J; Tauber, AI; Williamson, KC | 1 |
| Dacquet, C; Mironneau, C; Mironneau, J | 1 |
| Barrès, C; Cerutti, C; Morin, B; Sassard, J | 1 |
| Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H | 1 |
| Clothier, N; Dawidson, I; Diller, K; Rooth, P | 1 |
| Abe, K; Kogure, K; Watanabe, T | 1 |
| Carpenter, CL; Greenberg, DA; Marks, SS; Watson, DL | 1 |
| Dacquet, C; Loirand, G; Mironneau, C; Mironneau, J; Pacaud, P | 1 |
| Swartz, SL | 1 |
| Schilling, WP | 1 |
| Briand, V; Brisac, AM; Laurent, S; Legrand, M; Schmitt, H; Tsoucaris-Kupfer, D | 1 |
| Artalejo, AR; Cárdenas, AM; García, AG; Montiel, C; Sánchez-García, P | 1 |
| Akbarali, HI; Bieger, D; Triggle, CR | 1 |
| David-Dufilho, M; Devynck, MA; Morris, MJ | 1 |
| Hosey, MM; Ptasienski, J; Rengasamy, A | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Lazdunski, M | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M | 1 |
| Navarro, J | 1 |
| Reynolds, IJ; Snowman, AM; Snyder, SH | 1 |
| Cerione, RA; Horne, WA; Oswald, RE; Weiland, GA | 1 |
| Brandi, AM; Bression, D; Chaumet-Riffaud, P; Comte, A; Kiechel, JR; Peillon, F | 1 |
| Jie, K; Timmermans, PB; van Brummelen, P; van Zwieten, PA; Vermey, P | 1 |
| Brenner, O; Dooley, DJ; Mählmann, H; Osswald, H | 1 |
| Campbell, KP; Imagawa, T; Leung, AT; Sharp, AH | 1 |
| Oswald, RE; Weiland, GA | 1 |
| Lee, HR; Roeske, WR; Yamamura, HI | 1 |
| Barhanin, J; Borsotto, M; Lazdunski, M; Norman, RI | 1 |
| Karobath, M; Supavilai, P | 1 |
| Müller-Schweinitzer, E; Neumann, P | 1 |
| Handler, CE; Sowton, E | 1 |
| Cortés, R; Karobath, M; Palacios, JM; Supavilai, P | 1 |
| Ferry, DR; Glossmann, H; Goll, A | 2 |
| Hattori, K; Maruyama, K; Nagatomo, T; Qu, YL; Sugiyama, K; Takamizawa, C; Watanabe, K | 1 |
| Fitzpatrick, LA; Maercklein, PB; Ritchie, CK | 1 |
| Maniwa, T; Miyagishi, A; Nagatomo, T; Qu, YL; Sugiyama, K | 1 |
| Brauns, T; Glossmann, H; Haugland, RP; Kimball, SD; Prinz, H; Striessnig, J | 1 |
4 review(s) available for isradipine and oxadiazoles
| Article | Year |
|---|---|
Antiatherogenic properties of calcium antagonists.
Topics: Animals; Arteriosclerosis; Calcinosis; Calcium; Calcium Channel Blockers; Humans; Ion Channels; Isradipine; Muscle, Smooth, Vascular; Oxadiazoles | 1987 |
Calcium channels in the heart. Properties and modulation by dihydropyridine enantiomers.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Heart; Humans; Ion Channels; Isradipine; Nicotinic Acids; Oxadiazoles; Stereoisomerism | 1988 |
Calcium currents in embryonic and neonatal mammalian skeletal muscle.
Topics: Animals; Animals, Newborn; Barium; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electrophysiology; Embryo, Mammalian; Embryo, Nonmammalian; Ion Channels; Isradipine; Muscles; Oxadiazoles; Stereoisomerism | 1988 |
Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart.
Topics: Animals; Blood Circulation; Calcium Channel Blockers; Heart; Humans; Hypertension; Isradipine; Muscle, Smooth, Vascular; Myocardial Contraction; Oxadiazoles; Rats; Rats, Inbred SHR; Vasodilator Agents | 1987 |
6 trial(s) available for isradipine and oxadiazoles
| Article | Year |
|---|---|
Addition of the calcium antagonist PN 200-110 to pindolol markedly augments the antihypertensive effect in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium; Calcium Channel Blockers; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Oxadiazoles; Pindolol; Random Allocation | 1987 |
Efficacy of a new calcium antagonist PN 200-110 (isradipine) in angina pectoris.
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Humans; Isosorbide Dinitrate; Isradipine; Male; Nifedipine; Oxadiazoles; Placebos | 1987 |
Antihypertensive effect of a new dihydropyridine calcium antagonist, PN 200-110 (isradipine), combined with pindolol.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Oxadiazoles; Pindolol; Random Allocation | 1987 |
Treatment of essential hypertension with PN 200-110 (isradipine).
Topics: Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Isradipine; Male; Middle Aged; Oxadiazoles; Prazosin; Propranolol; Random Allocation; Time Factors | 1987 |
Influence of calcium entry blockade on alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in the forearm of hypertensive patients.
Topics: Adult; Azepines; Calcium Channel Blockers; Female; Forearm; Hemodynamics; Humans; Hypertension; Isradipine; Male; Methoxamine; Middle Aged; Nifedipine; Oxadiazoles; Receptors, Adrenergic, alpha; Regional Blood Flow; Vascular Resistance; Vasoconstriction | 1987 |
Safety, tolerability and efficacy of PN 200-110, a new calcium antagonist in patients with angina and coronary heart disease.
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Heart Rate; Hemodynamics; Humans; Isradipine; Male; Oxadiazoles | 1984 |
204 other study(ies) available for isradipine and oxadiazoles
| Article | Year |
|---|---|
Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140.
Topics: Alkaloids; Allosteric Regulation; Animals; Benzothiazoles; Benzylisoquinolines; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; Diltiazem; Guinea Pigs; Isomerism; Isradipine; Kinetics; Macromolecular Substances; Models, Theoretical; Muscles; Oxadiazoles; Pyridines; Pyrrolidines; Rabbits; Thiazoles; Verapamil | 1991 |
L-type cardiac calcium channels in doxorubicin cardiomyopathy in rats morphological, biochemical, and functional correlations.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Doxorubicin; Electric Conductivity; Female; Heart Failure; In Vitro Techniques; Isradipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1991 |
Kinetics of binding of dihydropyridine calcium channel ligands to skeletal muscle membranes: evidence for low-affinity sites and for the involvement of G proteins.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Isradipine; Kinetics; Ligands; Membrane Proteins; Microsomes; Muscles; Nitrendipine; Oxadiazoles; Rabbits; Receptors, Nicotinic; Stereoisomerism; Thionucleotides | 1991 |
Age related changes in Ca2+ channels in spontaneously hypertensive rats.
Topics: Aging; Animals; Body Weight; Brain; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques; Isradipine; Male; Muscle, Smooth, Vascular; Myocardium; Oxadiazoles; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1991 |
Spontaneous and corticotropin-releasing factor-induced cytosolic calcium transients in corticotrophs.
Topics: Action Potentials; Adenoma; Adrenocorticotropic Hormone; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Corticotropin-Releasing Hormone; Cytosol; Egtazic Acid; Female; Humans; Isradipine; Membrane Potentials; Oxadiazoles; Pituitary Gland; Pituitary Neoplasms; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Tetrodotoxin; Tumor Cells, Cultured | 1991 |
Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Atropine; Barium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cell Line; Cell Membrane; Enkephalin, Leucine-2-Alanine; Epinephrine; Evoked Potentials; GTP-Binding Proteins; Immune Sera; Isradipine; Membrane Potentials; Molecular Sequence Data; omega-Conotoxins; Oxadiazoles; Peptides; Peptides, Cyclic; Pertussis Toxin; Pheochromocytoma; Propranolol; Rats; Receptors, Adrenergic, beta; Receptors, Muscarinic; Virulence Factors, Bordetella; Yohimbine | 1991 |
Dual action of endothelin-1 on the Ca2(+)-activated K+ channel in smooth muscle cells of porcine coronary artery.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Coronary Vessels; Electrophysiology; Endothelins; In Vitro Techniques; Isradipine; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Potassium Channels; Rabbits; Swine | 1991 |
Dihydropyridine receptor binding sites in the cardiomyopathic hamster heart are unchanged from control.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Isradipine; Male; Myocardium; Oxadiazoles; Receptors, Nicotinic | 1991 |
Iminodipropionitrile-induced dyskinesia in mice: striatal calcium channel changes and sensitivity to calcium channel antagonists.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Corpus Striatum; Dyskinesia, Drug-Induced; Isradipine; Male; Mice; Nitriles; Oxadiazoles; Synaptosomes | 1991 |
Autoradiographic analysis of second messenger and neurotransmitter system receptors in the gerbil hippocampus following transient forebrain ischemia.
Topics: Adenosine; Adenylyl Cyclases; Animals; Autoradiography; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Colforsin; Gerbillinae; Hippocampus; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ischemic Attack, Transient; Isradipine; Male; Neurons; Organ Specificity; Oxadiazoles; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyramidal Tracts; Quinuclidinyl Benzilate; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; Receptors, Purinergic; Second Messenger Systems; Time Factors; Tritium | 1991 |
Role of calcium in regulation of phosphoinositide signaling pathway.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Carbachol; Cations, Divalent; Cells, Cultured; Cerebral Cortex; Diltiazem; Egtazic Acid; Inositol; Inositol Phosphates; Isradipine; Kinetics; Models, Neurological; Neurons; Oxadiazoles; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Rats; Signal Transduction; Sulfonamides; Verapamil | 1991 |
Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Ethanol; Isradipine; Male; Mice; Nimodipine; Nitrendipine; Oxadiazoles; Stereoisomerism; Substance Withdrawal Syndrome; Time Factors | 1990 |
Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Guanosine Triphosphate; Isradipine; Neurons; Nitrendipine; Oxadiazoles; Rats; Tumor Cells, Cultured | 1990 |
Differential effects of amiodarone and desethylamiodarone on calcium antagonist receptors.
Topics: Amiodarone; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Heart; In Vitro Techniques; Isradipine; Kinetics; Male; Muscles; Myocardium; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1990 |
Reduced L-type calcium current in the embryonic chick heart with persistent truncus arteriosus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Electrophysiology; Heart; Isradipine; Myocardium; Oxadiazoles; Receptors, Nicotinic; Truncus Arteriosus, Persistent | 1990 |
Selective antagonism of calcium channel activators by fluspirilene.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Binding, Competitive; Calcium Channel Agonists; Calcium Channel Blockers; Cecum; Cerebral Cortex; Female; Fluspirilene; Guinea Pigs; In Vitro Techniques; Isradipine; Kinetics; Muscle, Smooth; Oxadiazoles; Potassium; Pyridines; Radioligand Assay; Spiro Compounds | 1990 |
An endogenous Ca2+ channel agonist, endothelin-1, does not directly activate partially purified dihydropyridine-sensitive Ca2+ channel from cardiac muscle in a reconstituted system.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Endothelins; Heart; Isradipine; Kinetics; Liposomes; Microsomes; Oxadiazoles; Proteolipids; Sarcolemma; Swine; Verapamil | 1990 |
Characterization of 1,4, dihydropyridine calcium channel binding sites in the human prostate.
Topics: Binding Sites; Calcium Channel Blockers; Calcium Channels; Humans; In Vitro Techniques; Isradipine; Male; Nitrendipine; Oxadiazoles; Prostate; Prostatic Hyperplasia; Receptors, Nicotinic | 1990 |
Ca2+ channel inhibition by a new dihydropyridine derivative, S11568, and its enantiomers S12967 and S12968.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Radioisotopes; Cell Line; Dihydropyridines; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Inosine Triphosphate; Isradipine; Male; Muscle, Smooth, Vascular; Myocardium; Oxadiazoles; Rats; Ryanodine; Stereoisomerism | 1990 |
(-)[3H]amlodipine binding to rat cardiac membranes.
Topics: Amlodipine; Animals; Female; Gallopamil; Hydrogen-Ion Concentration; In Vitro Techniques; Isradipine; Kinetics; Membranes; Myocardium; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains; Stereoisomerism; Temperature | 1991 |
Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Binding Sites; Calcium Channels; Cell Line; Cell Membrane; Dihydropyridines; DNA; Electric Conductivity; Gene Expression; Ion Channel Gating; Isradipine; Kinetics; L Cells; Macromolecular Substances; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic; Transfection | 1991 |
Binding of the dihydropyridine calcium channel blocker (+)-[3H] isopropyl-4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2, 6-dimethyl-3-pyridinecarboxylate (PN200-110) to RINm5F membranes and cells: characterization and functional significanc
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cell Membrane; Insulin; Insulin Secretion; Islets of Langerhans; Isradipine; Membrane Potentials; Oxadiazoles; Potassium Chloride | 1991 |
Sustained increase in intracellular calcium promotes neuronal survival.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cell Survival; Chick Embryo; Extracellular Space; Intracellular Membranes; Isradipine; Neurons; Osmolar Concentration; Oxadiazoles; Potassium | 1991 |
Regulation of 1,4-dihydropyridine and beta-adrenergic receptor sites in coronary artery smooth muscle membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Coronary Vessels; Dogs; Isradipine; Male; Muscle, Smooth, Vascular; Oxadiazoles; Receptors, Adrenergic, beta; Receptors, Nicotinic; Temperature | 1991 |
Altered Ca2+ dynamics in single cardiac myocytes from renovascular hypertensive rats.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cardiomegaly; Cells, Cultured; Fura-2; Heart Ventricles; Hypertension, Renovascular; Isoproterenol; Isradipine; Kinetics; Male; Myocardium; Myosins; Oxadiazoles; Rats; Rats, Inbred Strains; Reference Values; Sarcolemma; Spectrometry, Fluorescence | 1991 |
The calcium antagonist PN 200-110 inhibits the reinforcing properties of cocaine.
Topics: Animals; Calcium Channel Blockers; Cocaine; Conditioning, Operant; Isradipine; Male; Motor Activity; Oxadiazoles; Rats; Rats, Inbred Strains; Reinforcement, Psychology | 1991 |
Synthesis and calcium antagonistic activity of some new 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; In Vitro Techniques; Isradipine; Microsomes; Oxadiazoles; Pyrimidines; Rats; Thiones | 1991 |
Lack of effect of PN 200-110 on neuronal injury and neurological outcome in middle cerebral artery-occluded rats.
Topics: Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Cerebral Arteries; Isradipine; Male; Nervous System; Neurons; Oxadiazoles; Rats; Rats, Inbred F344 | 1991 |
Denervation induced changes in level of Ca-antagonists binding cytosolic protein from white skeletal muscle.
Topics: Animals; Calcium Channel Blockers; Cytosol; Denervation; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Isradipine; Microsomes; Muscles; Oxadiazoles; Rabbits; Receptors, Cholinergic | 1991 |
A calcium channel antagonist stereoselectively decreases ethanol withdrawal hyperexcitability but not that due to bicuculline, in hippocampal slices.
Topics: Animals; Bicuculline; Calcium Channel Blockers; Ethanol; Evoked Potentials; Hippocampus; In Vitro Techniques; Isradipine; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Regression Analysis; Stereoisomerism; Substance Withdrawal Syndrome | 1991 |
[Effects of PN 200-110 on penicillin-induced epileptic activity in the cerebral cortex of rats].
Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; Epilepsies, Partial; Isradipine; Male; Oxadiazoles; Penicillins; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells.
Topics: Animals; Aorta; Basilar Artery; Binding Sites; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Isradipine; Muscle, Smooth, Vascular; Nicardipine; Nitrendipine; Oxadiazoles; Rats; Swine | 1991 |
Reduced calcium sensitivity of dihydropyridine binding to calcium channels in spontaneously hypertensive rats.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Male; Microsomes; Muscles; Myocardium; Oxadiazoles; Rats; Rats, Inbred SHR | 1991 |
Effect of propionyl-L-carnitine on L-type calcium channels in human heart sarcolemma.
Topics: Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Carnitine; Cell Membrane; Culture Techniques; Heart; Humans; Isradipine; Myocardium; Oxadiazoles; Radioligand Assay; Sarcolemma; Tritium | 1991 |
Calcium ions inhibit the allosteric interaction between the dihydropyridine and phenylalkylamine binding site on the voltage-gated calcium channel in heart sarcolemma but not in skeletal muscle transverse tubules.
Topics: Allosteric Regulation; Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Heart; In Vitro Techniques; Isradipine; Kinetics; Muscles; Myocardium; Nitrendipine; Oxadiazoles; Rabbits; Receptors, Nicotinic; Sarcolemma; Verapamil | 1990 |
Calcium channel ligand binding to intact, concanavalin A and cyclic AMP-treated cells of the immune system.
Topics: Animals; Bucladesine; Calcium Channels; Concanavalin A; Isradipine; Leukocytes, Mononuclear; Lymphocyte Activation; Mice; Mice, Inbred CBA; Nitrendipine; Oxadiazoles; Spleen; Verapamil | 1990 |
Thyroid hormones up-regulate Ca-channels in cultured skeletal muscle of the rat.
Topics: Animals; Animals, Newborn; Calcium Channels; Cells, Cultured; Isradipine; Kinetics; Muscle Proteins; Muscles; Oxadiazoles; Rats; Sodium Channels; Tetrodotoxin; Thyroid Hormones; Up-Regulation | 1990 |
Irreversible modification of the voltage-sensitive calcium channel by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channels; Guinea Pigs; Isradipine; Male; Muscle Contraction; omega-Conotoxin GVIA; Oxadiazoles; Peptides, Cyclic; Quinolines | 1990 |
Effect of inorganic calcium channel blockers on dihydropyridine binding to cardiac sarcolemma.
Topics: Animals; Cadmium; Calcimycin; Calcium; Calcium Channel Blockers; Dihydropyridines; Dogs; In Vitro Techniques; Isradipine; Lanthanum; Myocardium; Nitrendipine; Ouabain; Oxadiazoles; Quinuclidinyl Benzilate; Sarcolemma | 1990 |
Chronic treatment by the calcium channel blocker +/- PN 200-110 in the rat counteracts the stimulations of pituitary weight, prolactin release and pituitary C-kinase activity induced by a chronic estradiol treatment, in vivo.
Topics: Animals; Calcium Channel Blockers; Estradiol; Female; Isradipine; Organ Size; Oxadiazoles; Pituitary Gland; Prolactin; Protein Kinase C; Rats; Rats, Inbred Strains | 1990 |
Calcium antagonist, adenosine A1, and muscarinic bindings in rat hippocampus after transient ischemia.
Topics: Adenosine; Animals; Autoradiography; Binding Sites; Calcium Channel Blockers; Hippocampus; Ischemic Attack, Transient; Isradipine; Male; Oxadiazoles; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Purinergic; Time Factors; Tissue Distribution | 1990 |
4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Crystallization; Dihydropyridines; Guinea Pigs; Ileum; Isoxazoles; Isradipine; Molecular Conformation; Molecular Structure; Myocardium; Oxadiazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Increase in [3H]PN 200-110 binding to cardiac muscle membrane in streptozocin-induced diabetic rats.
Topics: Animals; Binding Sites; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; In Vitro Techniques; Insulin; Isradipine; Male; Membranes; Myocardium; Oxadiazoles; Rats; Rats, Inbred Strains; Streptozocin; Tritium; Verapamil | 1990 |
Ca2+ transport in myocardial sarcolemma from rainbow trout.
Topics: Animals; Binding Sites; Biological Transport; Calcium; Carrier Proteins; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Isradipine; Myocardium; Oxadiazoles; Salmonidae; Sodium-Calcium Exchanger; Trout | 1990 |
SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Indolizines; Isradipine; Male; Myocardium; Oxadiazoles; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Sarcolemma; Verapamil | 1990 |
1,4-Dihydropyridine activators in the tiamdipine series.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardium; Oxadiazoles; Potassium Chloride; Radioligand Assay; Rats; Rats, Inbred WKY; Stereoisomerism | 1990 |
Calcium binding to extracellular sites of skeletal muscle calcium channels regulates dihydropyridine binding.
Topics: Animals; Binding Sites; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cell Membrane; Dihydropyridines; Edetic Acid; Egtazic Acid; Isradipine; Magnesium; Microsomes; Muscles; Myocardium; Oxadiazoles; Rabbits; Sarcolemma | 1990 |
Calcium channel receptor sites for (+)-[3H]PN 200-110 in coronary artery.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Coronary Vessels; Diltiazem; Edetic Acid; Female; In Vitro Techniques; Isradipine; Kinetics; Male; Oxadiazoles; Receptors, Nicotinic; Swine; Verapamil | 1990 |
Identification, characterization, and photoaffinity labeling of the dihydropyridine receptor associated with the L-type calcium channel from bovine adrenal medulla.
Topics: Adrenal Medulla; Affinity Labels; Allosteric Regulation; Animals; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cattle; Dihydropyridines; Hot Temperature; Isradipine; Oxadiazoles; Photochemistry; Radioligand Assay; Receptors, Nicotinic; Stereoisomerism; Sulfhydryl Reagents | 1990 |
Calcium antagonist binding sites in failing and nonfailing human ventricular myocardium.
Topics: Calcium Channel Blockers; Calcium Channels; Cardiomyopathy, Dilated; Cell Membrane; Humans; Iodocyanopindolol; Isradipine; Kinetics; Myocardium; Nitrendipine; Oxadiazoles; Pindolol; Receptors, Adrenergic, beta; Receptors, Nicotinic | 1990 |
Identification of a new subpopulation of triad junctions isolated from skeletal muscle; morphological correlations with intact muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Fractionation; In Vitro Techniques; Isradipine; Kinetics; Microscopy, Electron; Microsomes; Muscles; Organelles; Oxadiazoles; Rabbits; Receptors, Cholinergic; Receptors, Nicotinic; Ryanodine Receptor Calcium Release Channel; Subcellular Fractions; Trypsin | 1990 |
Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Carps; Cell Membrane; Cerebral Cortex; Dihydropyridines; Diltiazem; Electric Conductivity; Guinea Pigs; Heparin; Isradipine; Molecular Sequence Data; Muscles; Myocardium; Nicotinic Antagonists; Oxadiazoles; Polyelectrolytes; Polymers; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1990 |
[3H]PN200-110 binding in a fibroblast cell line transformed with the alpha 1 subunit of the skeletal muscle L-type Ca2+ channel.
Topics: Animals; Brain; Calcium Channels; Cell Membrane; Cloning, Molecular; Diltiazem; Gallopamil; Imines; Isradipine; L Cells; Macromolecular Substances; Mice; Muscles; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma; Transfection | 1990 |
Protein kinase C participates in up-regulation of dihydropyridine-sensitive calcium channels by ethanol.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cell Membrane; Ethanol; Isradipine; Kinetics; Oxadiazoles; Pheochromocytoma; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Sphingosine | 1990 |
Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons.
Topics: Animals; Antibodies, Monoclonal; Calcium Channels; Dendrites; Dihydropyridines; Hippocampus; Immunoenzyme Techniques; Immunosorbent Techniques; Isradipine; Neurons; omega-Conotoxins; Oxadiazoles; Peptides, Cyclic; Rats; Rats, Inbred Strains; Synaptic Membranes | 1990 |
Different mechanisms of Ca2+ entry induced by depolarization and muscarinic receptor stimulation in SH-SY5Y human neuroblastoma cells.
Topics: Atropine; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Cell Membrane; Humans; Isradipine; Kinetics; Membrane Potentials; Neuroblastoma; Nickel; Oxadiazoles; Potassium; Receptors, Muscarinic | 1990 |
A radioreceptor assay for determination of nicardipine in human serum using 3H(+)PN 200-110 as radioligand.
Topics: Animals; Binding, Competitive; Calcium Channels; Humans; In Vitro Techniques; Isradipine; Kinetics; Male; Nicardipine; Nitrendipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Reproducibility of Results; Stereoisomerism; Tritium | 1990 |
Subtypes of voltage-sensitive calcium channels in cultured rat brain neurons.
Topics: Animals; Brain; Calcium; Calcium Channels; Cells, Cultured; Isradipine; Membrane Potentials; omega-Conotoxins; Oxadiazoles; Peptides, Cyclic; Rats | 1990 |
Interactions of cryptosin with mammalian cardiac dihydropyridine-specific calcium channels.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cardiac Glycosides; Cell Membrane; Dogs; Female; Guinea Pigs; In Vitro Techniques; Isradipine; Male; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma | 1990 |
Calcium currents of neuroblastoma x glioma hybrid cells after cultivation with dibutyryl cyclic AMP and nickel.
Topics: Animals; Bucladesine; Calcium Channels; Colforsin; Cycloheximide; Glioma; Hybrid Cells; Isradipine; Mice; Neuroblastoma; Nickel; Oxadiazoles; Rats; Tumor Cells, Cultured | 1990 |
Action of chlormethiazole in a model of ethanol withdrawal.
Topics: Animals; Calcium Channels; Chlormethiazole; Dihydropyridines; Ethanol; Isradipine; Male; Mice; Motor Activity; Oxadiazoles; Seizures; Substance Withdrawal Syndrome | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Biochemical characterization of plasma membrane isolated from human skeletal muscle.
Topics: Calcium Channel Blockers; Carrier Proteins; Cell Fractionation; Cell Membrane; Enzyme Activation; Humans; Ion Channels; Isradipine; Membrane Lipids; Membrane Proteins; Muscles; Ouabain; Oxadiazoles; Phosphoric Monoester Hydrolases; Receptors, Drug; Sodium Channels; Sodium-Potassium-Exchanging ATPase | 1985 |
Abnormal transverse tubule system and abnormal amount of receptors for Ca2+ channel inhibitors of the dihydropyridine family in skeletal muscle from mice with embryonic muscular dysgenesis.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Ion Channels; Isradipine; Mice; Mice, Mutant Strains; Microscopy, Electron; Muscles; Muscular Diseases; Myofibrils; Oxadiazoles; Receptors, Nicotinic; Sarcoplasmic Reticulum | 1985 |
Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination.
Topics: Animals; Benzodiazepinones; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Fractionation; Dogs; Ion Channels; Isoquinolines; Isradipine; Male; Molecular Weight; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Nicotinic; Sarcolemma; Sarcoplasmic Reticulum; Verapamil | 1985 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle cells in culture: electrophysiological properties and interactions with Ca2+ channel activator (Bay K8644) and inhibitor (PN 200-110).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Cells, Cultured; Electric Conductivity; Ion Channels; Isradipine; Membrane Potentials; Muscles; Nifedipine; Oxadiazoles; Rats | 1986 |
Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Ion Channels; Isradipine; Kinetics; Liposomes; Macromolecular Substances; Membrane Proteins; Microtubules; Molecular Weight; Muscles; Oxadiazoles; Phosphatidylcholines | 1986 |
Depolarization-dependent binding of the calcium channel antagonist, (+)-[3H]PN200-110, to intact cultured PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Calcium Channel Blockers; Cells, Cultured; Isradipine; Kinetics; Membrane Potentials; Nifedipine; Nitrendipine; Onium Compounds; Organophosphorus Compounds; Oxadiazoles; Potassium; Pyridines; Tritium | 1986 |
Cyclic GMP formation and inositol phosphate accumulation do not share common origins in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Cell Compartmentation; Cyclic GMP; Inositol Phosphates; Isradipine; Male; Oxadiazoles; Potassium; Rats; Rats, Inbred Strains; Sugar Phosphates; Type C Phospholipases | 1986 |
Antibodies reveal the cytolocalization and subunit structure of the 1,4-dihydropyridine component of the neuronal Ca2+ channel.
Topics: Animals; Antibodies; Autoradiography; Brain; Calcium; Calcium Channels; Fluorescent Antibody Technique; Immunosorbent Techniques; Ion Channels; Isradipine; Kinetics; Molecular Weight; Muscles; Neurons; Oxadiazoles; Rabbits; Receptors, Nicotinic; Synaptosomes; Tissue Distribution | 1986 |
Influence of Mg++ on the effect of diltiazem to increase dihydropyridine binding to receptors on Ca++-channels in chick cardiac and skeletal muscle membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Chickens; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Isradipine; Magnesium; Membranes; Muscles; Myocardium; Nitrendipine; Oxadiazoles; Receptors, Nicotinic | 1986 |
Regional characterization of agonist and depolarization-induced phosphoinositide hydrolysis in rat brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine; Brain; Calcium Channel Blockers; Carbachol; Hydrolysis; Isradipine; Male; Norepinephrine; Oxadiazoles; Phosphatidylinositols; Physostigmine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Muscarinic; Tissue Distribution | 1986 |
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil | 1986 |
Effects of dihydropyridines on tension and calcium-45 influx in isolated mesenteric resistance vessels from spontaneously hypertensive and normotensive rats.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Female; Ion Channels; Isradipine; Mesenteric Arteries; Nifedipine; Nisoldipine; Norepinephrine; Oxadiazoles; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1987 |
A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Ion Channels; Isradipine; Kinetics; Membrane Potentials; Membranes; Myocardium; Nicotinic Acids; Nimodipine; Nitrendipine; Oxadiazoles; Pyridines; Stereoisomerism; Structure-Activity Relationship | 1987 |
Relationship between beta-adrenoceptors and calcium channels in human ventricular myocardium.
Topics: Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Female; Humans; In Vitro Techniques; Iodobenzenes; Ion Channels; Isradipine; Male; Myocardium; Nimodipine; Oxadiazoles; Receptors, Adrenergic, beta | 1987 |
Dihydropyridine binding and calcium channel function in clonal rat adrenal medullary tumor cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Cell Membrane; Clone Cells; Electrophysiology; Ion Channels; Isradipine; Mathematics; Membrane Potentials; Nitrendipine; Oxadiazoles; Pheochromocytoma; Rats | 1987 |
Regulation of calcium channels in aortic muscle cells by protein kinase C activators (diacylglycerol and phorbol esters) and by peptides (vasopressin and bombesin) that stimulate phosphoinositide breakdown.
Topics: Animals; Aorta; Arginine Vasopressin; Bombesin; Calcium; Calcium Channel Blockers; Cell Line; Cyclic AMP; Diglycerides; Enzyme Activation; Ion Channels; Isradipine; Kinetics; Muscle, Smooth, Vascular; Oxadiazoles; Oxytocin; Phorbol Esters; Phosphatidylinositols; Protein Kinase C; Rats | 1987 |
Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential-dependent blockade by Ro 18-3981.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Isradipine; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Potassium; Pyridines | 1987 |
Dihydropyridine chirality at the chromaffin cell calcium channel.
Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cats; Chromaffin System; Dihydropyridines; Female; Ion Channels; Isradipine; Male; Oxadiazoles; Potassium; Pyridines; Stereoisomerism | 1987 |
Evidence for distinct calcium channel agonist and antagonist binding sites in intact cultured embryonic chick ventricular cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Heart Ventricles; Isradipine; Kinetics; Myocardial Contraction; Myocardium; Oxadiazoles; Radioligand Assay | 1987 |
Beneficial effects of the calcium antagonist PN 200-110 in patients with congestive heart failure.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Heart Failure; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Oxadiazoles; Physical Exertion | 1987 |
The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channels; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Verapamil | 1987 |
Monoclonal antibody identifies a 200-kDa subunit of the dihydropyridine-sensitive calcium channel.
Topics: Animals; Antibodies, Monoclonal; Calcium; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Ion Channels; Isradipine; Macromolecular Substances; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits | 1987 |
Insulin enhances development of functional voltage-dependent Ca2+ channels in aneurally cultured human muscle.
Topics: Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factors; Humans; Insulin; Ion Channels; Isradipine; Membrane Potentials; Muscles; Oxadiazoles; Potassium | 1987 |
Comparison of molecular properties of the voltage-sensitive Ca2+ channel from longitudinal smooth muscle of rabbit ileum with the channel purified from transverse tubules of rabbit skeletal muscle.
Topics: Animals; Antigen-Antibody Reactions; Calcium; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Electrophysiology; Ileum; Immune Sera; Ion Channels; Isradipine; Muscle, Smooth; Muscles; Oxadiazoles; Rabbits; Receptors, Drug; Solubility | 1987 |
Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Membrane Proteins; Molecular Weight; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma | 1987 |
Effect of daunorubicin on dihydropyridine-sensitive binding sites in cardiac sarcolemma.
Topics: Animals; Calcium; Cricetinae; Daunorubicin; Dihydropyridines; Female; In Vitro Techniques; Ion Channels; Isradipine; Male; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Sarcolemma | 1987 |
Pharmacologic relevance of dihydropyridine binding sites in membranes from rat aorta: kinetic and equilibrium studies.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Binding, Competitive; Calcium; Calcium Channels; Ion Channels; Isradipine; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism | 1988 |
Effects of dihydropyridine calcium channel modulators on cardiac sodium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Heart; Ion Channels; Isradipine; Myocardium; Nitrendipine; Oxadiazoles; Rats; Receptors, Nicotinic; Sodium; Stereoisomerism | 1988 |
Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Ion Channels; Isradipine; Kinetics; Lipid Bilayers; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic | 1987 |
L-type calcium channels are modified in rat hippocampus by short-term experimental ischemia.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane; Cerebral Cortex; Corpus Striatum; Hippocampus; Ion Channels; Ischemic Attack, Transient; Isradipine; Kinetics; Male; Oxadiazoles; Rats; Rats, Inbred Strains | 1988 |
Leiurus quinquestriatus venom inhibits BRL 34915-induced 86Rb+ efflux from the rat portal vein.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Isradipine; Oxadiazoles; Portal Vein; Potassium; Pyrroles; Rats; Rubidium Radioisotopes; Scorpion Venoms; Vasodilator Agents | 1988 |
Dihydropyridine-sensitive Ca2+ channel in aneurally cultured human muscles. Relationship between high-affinity binding site and inhibition of calcium uptake.
Topics: Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cells, Cultured; Dihydropyridines; Electrophysiology; Humans; Ion Channels; Isradipine; Muscles; Nitrendipine; Oxadiazoles; Potassium | 1988 |
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Rabbits; Rats; Time Factors | 1987 |
Functional dihydropyridine binding site associated with slow calcium channel in rat cultured neurones.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Binding, Competitive; Calcium; Calcium Channels; Cells, Cultured; Frontal Lobe; Ion Channels; Isradipine; Oxadiazoles; Potassium; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1988 |
Structural analysis of the calcium channel by photoaffinity labelling and limited proteolysis.
Topics: Affinity Labels; Animals; Calcium; Calcium Channel Blockers; Ion Channels; Isradipine; Membrane Proteins; Molecular Weight; Muscles; Oxadiazoles; Papain; Peptide Fragments; Peptide Mapping; Rabbits | 1988 |
Binding of dihydropyridine calcium antagonists to membranes from human skeletal muscle.
Topics: Animals; Azides; Binding Sites; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Humans; In Vitro Techniques; Ion Channels; Isradipine; Muscle Proteins; Muscles; Oxadiazoles; Rabbits | 1988 |
Effect of calcium channel modulators on isolated endothelial cells.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Biological Products; Bradykinin; Calcium; Carbachol; Cattle; Diltiazem; Endothelium; Fura-2; Ion Channels; Isradipine; Nitric Oxide; Oxadiazoles; Thrombin; Verapamil | 1988 |
Potential-dependent allosteric modulation of 1,4-dihydropyridine binding by d-(cis)-diltiazem and (+/-)-verapamil in living cardiac cells.
Topics: Allosteric Regulation; Animals; Calcium; Diltiazem; Heart; In Vitro Techniques; Ion Channels; Isradipine; Membrane Potentials; Myocardium; Oxadiazoles; Rats; Sarcolemma; Verapamil | 1988 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
Multiple calcium channels in synaptosomes: voltage dependence of 1,4-dihydropyridine binding and effects on function.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Male; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Verapamil | 1988 |
Central modulation of baroreceptor reflex response to phenylephrine by dihydropyridines in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine Derivatives; Blood Pressure; Brain; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Muscarine; Oxadiazoles; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reflex | 1988 |
Molecular mechanism of action of the vasoconstrictor peptide endothelin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Electrophysiology; Endothelins; Endothelium, Vascular; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isradipine; Oxadiazoles; Peptides; Phosphatidylinositols; Rats; Rats, Inbred Strains; Vasoconstriction; Vasopressins | 1988 |
Involvement of DHP voltage-sensitive calcium channels and protein kinase C in thyroliberin (TRH) release by developing hypothalamic neurons in culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Hypothalamus; Ion Channels; Isradipine; Mice; Mollusk Venoms; Neurons; omega-Conotoxins; Oxadiazoles; Phorbol Esters; Potassium; Reference Values; Thyrotropin-Releasing Hormone | 1988 |
Secretion from adrenaline- and noradrenaline-storing adrenomedullary cells is regulated by a common dihydropyridine-sensitive calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium; Calcium Channel Blockers; Cats; Dihydropyridines; Dimethylphenylpiperazinium Iodide; Epinephrine; In Vitro Techniques; Ion Channels; Isradipine; Norepinephrine; Oxadiazoles; Potassium; Reference Values | 1988 |
Developmental regulation of cardiac calcium channels and contractile sensitivity to [Ca]o.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channels; Chick Embryo; Isradipine; Kinetics; Myocardial Contraction; Oxadiazoles | 1989 |
Dihydropyridine binding sites in aerobically perfused, ischemic, and reperfused rat hearts: effect of temperature and time.
Topics: Aerobiosis; Animals; Body Temperature; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques; Isradipine; Male; Membranes; Myocardial Reperfusion; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Reperfusion Injury; Time Factors | 1988 |
Adaptational process of the cardiac Ca2+ channels to pressure overload: biochemical and physiological properties of the dihydropyridine receptors in normal and hypertrophied rat hearts.
Topics: Adaptation, Physiological; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cardiomegaly; Heart; In Vitro Techniques; Isradipine; Kinetics; Male; Myocardium; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Sarcolemma | 1988 |
Effect of some potassium channel blockers on contractile responses of the rabbit aorta.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Aorta, Thoracic; Apamin; Calcium Channel Blockers; Endothelium, Vascular; Female; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Potassium Channels; Rabbits; Scorpion Venoms; Tetraethylammonium Compounds | 1989 |
Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium channel antagonist receptors in cultured neural (PC12) cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Ethanol; Isradipine; Nerve Tissue; Oxadiazoles; Pheochromocytoma; Rats; Receptors, Nicotinic; Stereoisomerism; Time Factors; Tumor Cells, Cultured | 1989 |
Calcium channel agonist and antagonist binding in a highly enriched sarcolemma preparation obtained from canine ventricle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dogs; Dose-Response Relationship, Drug; Heart Ventricles; Imines; In Vitro Techniques; Isradipine; Oxadiazoles; Sarcolemma | 1989 |
Voltage-dependent calcium channels in skeletal muscle transverse tubules. Measurements of calcium efflux in membrane vesicles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzothiazoles; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Carbocyanines; Cell Membrane; Dihydropyridines; Edetic Acid; Fluorescent Dyes; Isradipine; Lanthanum; Membrane Potentials; Muscles; Nitrendipine; Oxadiazoles; Potassium; Rabbits; Verapamil | 1989 |
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydropyridines; Indicators and Reagents; Isradipine; Male; Myocardium; Oxadiazoles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Nicotinic; Time Factors; Verapamil | 1989 |
Electrophysiological properties of isradipine (PN200-110) in humans.
Topics: Adult; Calcium Channel Blockers; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Humans; Injections, Intravenous; Isradipine; Male; Oxadiazoles; Refractory Period, Electrophysiological; Sick Sinus Syndrome; Sinoatrial Node | 1989 |
Calcium current in embryonic Xenopus muscle cells in culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cells, Cultured; Embryo, Nonmammalian; Isradipine; Muscles; Nifedipine; Oxadiazoles; Xenopus | 1989 |
Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Gene Expression; Isradipine; Kinetics; Oxadiazoles; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1989 |
(+)-[3H]-PN 200-110 binding to cell membranes and intact strips of portal vein smooth muscle: characterization and modulation by membrane potential and divalent cations.
Topics: Animals; Calcium Channel Blockers; Cations; Cell Membrane; Horses; In Vitro Techniques; Isradipine; Membrane Potentials; Muscle, Smooth, Vascular; Oxadiazoles; Portal Vein; Rats | 1989 |
Characteristics of specific bindings of nitrendipine and PN200-110 to various crude membranes: induction of irreversible bindings by UV irradiation.
Topics: Animals; Calcium Channel Blockers; Female; In Vitro Techniques; Isradipine; Male; Membranes; Muscle, Smooth; Muscles; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Time Factors; Ultraviolet Rays | 1989 |
(+)-PN200-110 and ouabain binding sites in purified bovine adrenomedullary plasma membranes and chromaffin cells.
Topics: Adrenal Medulla; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cattle; Cell Membrane; Chromaffin System; Dihydropyridines; Isradipine; Kinetics; Ouabain; Oxadiazoles; Stereoisomerism | 1989 |
Cortical dihydropyridine binding sites are unaltered in human alcoholic brain.
Topics: Alcoholism; Cerebral Cortex; Dihydropyridines; Humans; Isradipine; Male; Middle Aged; Nitrendipine; Oxadiazoles | 1989 |
Relaxation of potassium chloride-induced contractions by amlodipine and its interaction with the 1,4-dihydropyridine-binding site in pig coronary artery.
Topics: Amlodipine; Animals; Binding Sites; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Isradipine; Nifedipine; Oxadiazoles; Potassium Chloride; Sarcolemma; Stereoisomerism; Swine; Vasoconstriction; Vasodilation | 1989 |
Effect of plasma protein binding on kinetics of PN 200-110 in the isolated perfused rat heart.
Topics: Animals; Blood Proteins; Heart; In Vitro Techniques; Isradipine; Male; Models, Biological; Myocardium; Oxadiazoles; Perfusion; Rats; Rats, Inbred Strains; Serum Albumin, Bovine | 1989 |
Effects of McN-6186 on voltage-dependent Ca++ channels in heart and pituitary cells.
Topics: Amphetamines; Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; DOM 2,5-Dimethoxy-4-Methylamphetamine; Heart; Isradipine; Membrane Potentials; Oxadiazoles; Pituitary Gland; Rats; Tumor Cells, Cultured | 1989 |
Inhibition of dihydropyridine-sensitive calcium channels by the plant alkaloid ryanodine.
Topics: Alkaloids; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Lipid Bilayers; Microsomes; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic; Ryanodine | 1989 |
The failure of endothelin to displace bound, radioactively-labelled, calcium antagonists (PN 200/110, D888 and diltiazem).
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endothelins; Female; In Vitro Techniques; Isradipine; Oxadiazoles; Peptides; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1989 |
Calcium channel antagonist receptors in cerebral cortex from alcoholic patients.
Topics: Aged; Alcoholism; Calcium Channel Blockers; Calcium Channels; Frontal Lobe; Humans; Isradipine; Middle Aged; Oxadiazoles | 1989 |
Voltage-dependent binding of 1,4-dihydropyridine Ca2+ channel antagonists and activators in cultured neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Diltiazem; Gallopamil; Heart Ventricles; In Vitro Techniques; Isradipine; Membrane Potentials; Oxadiazoles; Potassium; Rats | 1989 |
Binding Ca2+ to intracellular or to extracellular sites of dihydropyridine receptor of rabbit skeletal muscle discriminates between in vitro binding of Ca2+-channel agonist and antagonist.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Intracellular Membranes; Isradipine; Kinetics; Microtubules; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic | 1989 |
Ca2+ channels in chick neural retina cells characterized by 1,4-dihydropyridine antagonists and activators.
Topics: Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Chick Embryo; Dihydropyridines; Isradipine; Neuroglia; Neuromuscular Depolarizing Agents; Oxadiazoles; Potassium; Retina; Stereoisomerism | 1989 |
Is Ca2+ antagonists binding protein from cytosolic fraction the precursor of alpha 1-subunit of Ca2+ channel?
Topics: Affinity Labels; Animals; Antibodies; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cytoplasm; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Oxadiazoles; Protein Precursors; Rabbits; Radioligand Assay; Receptors, Nicotinic; Ultraviolet Rays; Verapamil | 1989 |
The pharmacological properties of the peptide, endothelin.
Topics: Animals; Blood Pressure; Calcium Channels; Carbachol; Cerebral Cortex; Endothelins; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol; Isradipine; Male; Mollusk Venoms; Muscle Contraction; Muscle, Smooth, Vascular; Muscles; omega-Conotoxin GVIA; Oxadiazoles; Peptides; Phenylephrine; Potassium Chloride; Rabbits; Rats; Rats, Inbred Strains | 1989 |
High affinity binding of the calcium channel blocker, (+)-[methyl-3H]PN200-110(3HPN) in rat brain.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Male; Nifedipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptosomes | 1989 |
Pharmacological properties of voltage-dependent calcium channels in functional microvessels isolated from rat brain.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; In Vitro Techniques; Isradipine; Kinetics; Membrane Potentials; Microcirculation; Muscle, Smooth, Vascular; Nimodipine; Oxadiazoles; Potassium Chloride; Rats | 1989 |
[3H]PN200-110 and [3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes.
Topics: Alkaloids; Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Chlorides; Dihydropyridines; Electrophoresis; Isradipine; Lipid Bilayers; Membrane Proteins; Membranes; Muscles; Oxadiazoles; Potassium Channels; Rabbits; Ryanodine; Sarcoplasmic Reticulum; Tritium | 1989 |
[3H]HOE166 defines a novel calcium antagonist drug receptor--distinct from the 1,4 dihydropyridine binding domain.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drosophila; Guinea Pigs; In Vitro Techniques; Isradipine; Kinetics; Membranes; Muscles; Oxadiazoles; Piperidines; Proteins; Receptors, Nicotinic; Thiazines | 1989 |
Antagonist drug selectivity for radioligand binding sites on voltage-gated and N-methyl-D-aspartate receptor-gated Ca2+ channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dizocilpine Maleate; Ion Channel Gating; Isradipine; Male; Oxadiazoles; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1989 |
Characterization of the effects of omega-conotoxin GVIA on the responses of voltage-sensitive calcium channels.
Topics: Acetylcholine; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Isradipine; Male; Membranes; Mollusk Venoms; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurotransmitter Agents; omega-Conotoxin GVIA; Oxadiazoles; Potassium; Rats; Rats, Inbred Strains | 1989 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
Prolonged depolarization increases the pharmacological effect of dihydropyridines and their binding affinity for calcium channels of vascular smooth muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques; Isradipine; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Oxadiazoles; Potassium; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism; Vasoconstriction | 1987 |
Depolarization of chick myotubes triggers the appearance of (+)-[3H]PN 200-110-binding sites.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Isradipine; Muscles; Nitrendipine; Oxadiazoles; Receptors, Nicotinic | 1987 |
Control of expression of the 1,4-dihydropyridine receptor in BC3H1 cells.
Topics: Animals; Binding, Competitive; Calcium Channels; Cell Differentiation; Cell Line; Dihydropyridines; Isradipine; Mice; Muscles; Oxadiazoles; Peptides; Receptors, Nicotinic; Transforming Growth Factors | 1988 |
Developmental changes of the distribution of binding sites for organic Ca2+-channel blockers in cat visual cortex.
Topics: Aging; Animals; Autoradiography; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cats; Dihydropyridines; Image Processing, Computer-Assisted; Isradipine; Oxadiazoles; Receptors, Nicotinic; Visual Cortex | 1988 |
Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166.
Topics: Action Potentials; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Guinea Pigs; Heart; Hippocampus; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle, Smooth; Muscles; Myocardial Contraction; Myocardium; Oxadiazoles; Papillary Muscles; Piperidines; Rabbits; Receptors, Nicotinic; Splanchnic Circulation; Strophanthins; Thiazines | 1988 |
Altered calcium regulation in the cardiac plasma membrane in experimental renal hypertension.
Topics: Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Hypertension, Renal; Isradipine; Male; Oxadiazoles; Rats; Rats, Inbred Strains; Sarcolemma; Subcellular Fractions | 1988 |
Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Potentials; Isradipine; Mice; Muscle Contraction; Oxadiazoles; Piperidines; Thiazines; Verapamil | 1988 |
Voltage-dependent binding of dihydropyridine calcium channel blockers to guinea pig ventricular myocytes.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Centrifugation, Density Gradient; Guinea Pigs; In Vitro Techniques; Isradipine; Membrane Potentials; Myocardium; Oxadiazoles; Potassium; Receptors, Nicotinic; Sodium Channels | 1988 |
Selective modulation by membrane potential of the interaction of some calcium entry blockers with calcium channels in rat mesenteric artery.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Flunarizine; In Vitro Techniques; Isradipine; Membrane Potentials; Membranes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1988 |
Effects of PN 200-110, a new calcium antagonist, on alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction elicited by selective alpha-adrenoceptor agonists and catecholamines in the pithed rat.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Calcium Channel Blockers; Catecholamines; Decerebrate State; Epinephrine; Imidazoles; Isradipine; Male; Norepinephrine; Oxadiazoles; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoconstriction | 1985 |
Interaction between two calcium antagonists and two beta blockers in conscious rabbits: hemodynamic consequences of differing cardiodepressant properties.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Consciousness; Drug Interactions; Hemodynamics; Humans; Isradipine; Oxadiazoles; Pindolol; Propranolol; Rabbits; Verapamil | 1987 |
L-glutamate increases internal free calcium levels in synaptoneurosomes from immature rat brain via quisqualate receptors.
Topics: Animals; Brain; Calcimycin; Calcium; Egtazic Acid; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Isradipine; Male; Osmolar Concentration; Oxadiazoles; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes; Tetrodotoxin; Veratridine | 1988 |
Cardioprotection by the calcium antagonist PN 200-110 in the absence and presence of cardiodepression.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; In Vitro Techniques; Isradipine; Myocardial Contraction; Myocardium; Oxadiazoles; Rabbits; Time Factors; Verapamil | 1985 |
Characterization of binding sites for two classes of calcium channel antagonists in human forebrain.
Topics: Aniline Compounds; Autoradiography; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Humans; In Vitro Techniques; Isradipine; Kinetics; Membranes; Oxadiazoles; Pyridines | 1985 |
Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110.
Topics: Animals; Aorta; Arteriosclerosis; Calcium Channel Blockers; Cholesterol, Dietary; Endothelium; Hemodynamics; Isradipine; Male; Microscopy, Electron, Scanning; Oxadiazoles; Parasympathetic Nervous System; Rabbits | 1986 |
The effect of calcium-blockers nicardipine, darodipine, PN-200-110 and nifedipine on insulin release from isolated rat pancreatic islets.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isradipine; Male; Nicardipine; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1986 |
Inhibition of calcium flux and calcium channel antagonist binding in the PC12 neural cell line by phorbol esters and protein kinase C.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Diglycerides; Enzyme Activation; Isradipine; Mice; Neural Crest; Oxadiazoles; Phorbol Esters; Phorbols; Potassium; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Suppression of rat carotid lesion development by the calcium channel blocker PN 200-110.
Topics: Angioplasty, Balloon; Animals; Arteriosclerosis; Blood Platelets; Blood Pressure; Carotid Arteries; Hypotension; Isradipine; Male; Muscle, Smooth, Vascular; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1986 |
A nimodipine-resistant Ca2+ pathway is involved in myogenic tone in a resistance artery.
Topics: Analysis of Variance; Animals; Arteries; Calcium; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Isradipine; Male; Manganese; Muscle, Smooth, Vascular; Nicotinic Acids; Nimodipine; Oxadiazoles; Potassium; Rabbits; Vascular Resistance; Verapamil | 1986 |
Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Division; Cell Line; Cell Survival; Isradipine; Oxadiazoles; Pheochromocytoma; Rats; Receptors, Estrogen; Tamoxifen; Tritium | 1987 |
Comparison of cardiodepressant and vasodilator effects of PN 200-110 (isradipine), nifedipine and diltiazem in anesthetized rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dose-Response Relationship, Drug; Heart; Isradipine; Myocardial Contraction; Nifedipine; Oxadiazoles; Rabbits; Vasodilation | 1987 |
Hemodynamic effects of PN 200-110 (isradipine) in congestive heart failure.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Oxadiazoles; Time Factors | 1987 |
Vascular bed and vasoconstrictor-dependent selectivity of the calcium channel antagonist, PN 200-110.
Topics: Animals; Basilar Artery; Calcium Channel Blockers; Coronary Circulation; Histamine; In Vitro Techniques; Isradipine; Male; Oxadiazoles; Potassium; Rabbits; Regional Blood Flow; Vasoconstriction | 1986 |
The binding sites of the calcium antagonist [3H] PN 200,110 in the human myometrium and myosalpinx.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Humans; Isradipine; Middle Aged; Muscle, Smooth; Myometrium; Oxadiazoles; Uterine Contraction; Uterus | 1986 |
Enhancement of binding of the dihydropyridine calcium antagonist PN200-110 to human myometrial sarcolemma by the heterologous calcium antagonist diltiazem.
Topics: Calcium Channel Blockers; Cell Fractionation; Diltiazem; Female; Humans; Isradipine; Kinetics; Myometrium; Oxadiazoles; Sarcolemma; Subcellular Fractions | 1987 |
Similar increase in circulating renin after equihypotensive doses of nitroprusside, dihydralazine or isradipine in conscious rabbits.
Topics: Animals; Calcium Channel Blockers; Dihydralazine; Female; Ferricyanides; Hemodynamics; Hydralazine; Isradipine; Male; Nitroprusside; Oxadiazoles; Rabbits; Renin | 1987 |
Characterization of dihydropyridine binding sites in the rat brain: hypertension and age-dependent modulation of [3H](+)-PN 200-110 binding.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Hypertension; Isradipine; Male; Oxadiazoles; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Tritium | 1987 |
Pharmacokinetics of PN 200-110 (isradipine), a new calcium antagonist, after oral administration in man.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Humans; Intestinal Absorption; Isradipine; Kinetics; Male; Oxadiazoles | 1987 |
Failure of a new calcium-antagonist PN 200-110 and nifedipine to affect exercise stimulated GH-secretion in healthy volunteers.
Topics: Adult; Calcium Channel Blockers; Growth Hormone; Humans; Isradipine; Male; Nifedipine; Oxadiazoles; Physical Exertion | 1987 |
Nisoldepine inhibits formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) receptor-coupled calcium transport in human neutrophils.
Topics: Adult; Biological Transport; Calcium; Calcium Channel Blockers; Humans; In Vitro Techniques; Isradipine; Neutrophils; Nifedipine; Nisoldipine; Oxadiazoles; Receptors, Formyl Peptide; Receptors, Immunologic | 1987 |
Effects of calcium entry blockers on calcium-dependent contractions of rat portal vein.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Portal Vein; Potassium; Rats; Rats, Inbred Strains | 1987 |
Cardiovascular effects of two new calcium antagonists, PY 108-068 and PN 200-110, in conscious spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Isradipine; Male; Nifedipine; Nitroglycerin; Oxadiazoles; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred SHR; Reflex | 1988 |
A novel high affinity class of Ca2+ channel blockers.
Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil | 1988 |
In vivo fluorescence microscopy reveals cyclosporine G to be less nephrotoxic than cyclosporine A.
Topics: Animals; Calcium Channel Blockers; Cyclosporine; Cyclosporins; Female; Isradipine; Kidney; Male; Mice; Microcirculation; Microscopy, Fluorescence; Oxadiazoles; Regional Blood Flow | 1988 |
Prevention of ischemic and postischemic brain edema by a novel calcium antagonist (PN200-110).
Topics: Animals; Autoradiography; Brain Edema; Brain Ischemia; Calcium; Calcium Channel Blockers; Isradipine; Oxadiazoles | 1988 |
Striatal calcium channel antagonist receptors in Huntington's disease and Parkinson's disease.
Topics: Aged; Calcium Channel Blockers; Corpus Striatum; Humans; Huntington Disease; Isradipine; Middle Aged; Nerve Degeneration; Neural Pathways; Neurons; Oxadiazoles; Parkinson Disease; Substantia Nigra | 1988 |
Comparison of binding affinities and calcium current inhibitory effects of a 1,4-dihydropyridine derivative (PN 200-110) in vascular smooth muscle.
Topics: Animals; Binding Sites; Calcium; Electrophysiology; Horses; Isradipine; Kinetics; Muscle, Smooth, Vascular; Nicardipine; Oxadiazoles; Stereoisomerism | 1988 |
Antihypertensive and hormonal effects of PN 200-110, a new calcium-channel blocker, in essential hypertension.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Calcium Channel Blockers; Dinoprostone; Female; Hormones; Humans; Hypertension; Isradipine; Male; Middle Aged; Oxadiazoles; Prostaglandins E; Renin; Vascular Resistance | 1987 |
Effect of divalent cation chelation on dihydropyridine binding in isolated cardiac sarcolemma vesicles.
Topics: Animals; Calcimycin; Calcium; Cations, Divalent; Dihydropyridines; Dogs; Edetic Acid; Hydrogen-Ion Concentration; Isradipine; Magnesium; Myocardium; Nitrendipine; Ouabain; Oxadiazoles; Phosphates; Sarcolemma | 1988 |
Central and peripheral cardiovascular effects of the enantiomers of the calcium antagonist PN 200-110.
Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Chick Embryo; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Isradipine; Male; Oxadiazoles; Rats; Rats, Inbred SHR; Regional Blood Flow; Stereoisomerism | 1988 |
Sodium-dependent inhibition by PN200-110 enantiomers of nicotinic adrenal catecholamine release.
Topics: Adrenal Glands; Animals; Calcium Channel Blockers; Catecholamines; Cats; Dimethylphenylpiperazinium Iodide; Epinephrine; Female; In Vitro Techniques; Isradipine; Male; Norepinephrine; Oxadiazoles; Perfusion; Potassium; Receptors, Nicotinic; Sodium; Stereoisomerism | 1988 |
Inhibition of field stimulation-evoked relaxations in rat oesophageal smooth muscle by the calcium antagonist PN 200-110.
Topics: Animals; Calcium Channel Blockers; Dioxolanes; Electric Stimulation; Esophagus; In Vitro Techniques; Isometric Contraction; Isradipine; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Rats; Rats, Inbred Strains; Tetrodotoxin | 1988 |
Red blood cell ionized calcium concentration in spontaneous hypertension: modulation in vivo by the calcium antagonist PN 200.110.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Erythrocytes; Hypertension; In Vitro Techniques; Isradipine; Male; Oxadiazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1988 |
Purification of the cardiac 1,4-dihydropyridine receptor/calcium channel complex.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chickens; Isradipine; Kinetics; Membranes; Molecular Weight; Myocardium; Oxadiazoles; Receptors, Nicotinic | 1985 |
The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition.
Topics: Animals; Anura; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chickens; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Isradipine; Microsomes; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Solubility | 1985 |
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil | 1986 |
Dihydropyridine [methyl-3H]PN 200-110 binding and myogenesis in intact muscle cells in vitro.
Topics: Aminoquinolines; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Isradipine; Kinetics; Muscles; Nifedipine; Nitrendipine; Oxadiazoles; Receptors, Nicotinic | 1986 |
(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.
Topics: Animals; Brain Chemistry; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Female; Isradipine; Kinetics; Male; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Temperature; Tritium; Verapamil | 1986 |
Rapid incorporation of the solubilized dihydropyridine receptor into phospholipid vesicles.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Centrifugation, Density Gradient; Cholic Acids; Drug Stability; Isradipine; Liposomes; Male; Oxadiazoles; Rabbits; Receptors, Nicotinic; Solubility; Temperature | 1986 |
Binding of (+)-PN 200-110 to rat pituitaries and to normal and adenomatous human pituitaries.
Topics: Adenoma; Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Calcium Channels; Female; Humans; In Vitro Techniques; Isradipine; Myocardium; Oxadiazoles; Pituitary Gland; Pituitary Neoplasms; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1987 |
Characterization of the dihydropyridine binding sites of rat neocortical synaptosomes and microvessels.
Topics: Animals; Binding Sites; Calcium Channels; Cerebral Cortex; Isradipine; Kinetics; Male; Microcirculation; Microscopy, Electron; Muscle, Smooth, Vascular; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptosomes | 1987 |
Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Dihydropyridines; Isradipine; Molecular Weight; Muscles; Oxadiazoles; Photochemistry; Pyridines; Rabbits; Receptors, Nicotinic | 1987 |
The mechanism of binding of dihydropyridine calcium channel blockers to rat brain membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Isomerism; Isradipine; Kinetics; Mathematics; Nifedipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Time Factors | 1985 |
High affinity specific [3H](+)PN 200-110 binding to dihydropyridine receptors associated with calcium channels in rat cerebral cortex and heart.
Topics: Animals; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Ion Channels; Isradipine; Kinetics; Male; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1984 |
Purification of the dihydropyridine receptor of the voltage-dependent Ca2+ channel from skeletal muscle transverse tubules using (+) [3H]PN 200-110.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Ion Channels; Isradipine; Kinetics; Microtubules; Molecular Weight; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic | 1984 |
The interaction of [3H]PY 108-068 and of [3H]PN 200-110 with calcium channel binding sites in rat brain.
Topics: Animals; Brain; In Vitro Techniques; Ion Channels; Isradipine; Kinetics; Male; Membranes; Molecular Conformation; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
In vitro effects of calcium antagonists PN 200-110, nifedipine, and nimodipine on human and canine cerebral arteries.
Topics: Animals; Basilar Artery; Blood Physiological Phenomena; Calcium Channel Blockers; Cerebral Arteries; Dogs; Humans; In Vitro Techniques; Isradipine; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Nimodipine; Oxadiazoles; Serotonin; Vasoconstriction | 1983 |
Calcium antagonist binding sites in the rat brain: quantitative autoradiographic mapping using the 1,4-dihydropyridines [3H]PN 200-110 and [3H]PY 108-068.
Topics: Animals; Autoradiography; Binding Sites; Brain; Calcium Channel Blockers; Isradipine; Male; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1984 |
Target size analysis of skeletal muscle Ca2+ channels. Positive allosteric heterotropic regulation by d-cis-diltiazem is associated with apparent channel oligomer dissociation.
Topics: Allosteric Regulation; Animals; Benzazepines; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Male; Muscles; Oxadiazoles; Stereoisomerism | 1983 |
Differential labelling of putative skeletal muscle calcium channels by [3H]-nifedipine, [3H]-nitrendipine, [3H]-nimodipine and [3H]-PN 200 110.
Topics: Animals; Calcium Channel Blockers; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Kinetics; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles | 1983 |
Residual inhibition in density of [3H]isradipine binding sites in rat brain membrane pretreated with amlodipine.
Topics: Amlodipine; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Nifedipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Wistar | 1995 |
Direct effect of calcium channel antagonists on osteoclast function: alterations in bone resorption and intracellular calcium concentrations.
Topics: Animals; Bone Resorption; Calcium; Calcium Channel Blockers; Cells, Cultured; Intracellular Membranes; Isomerism; Isradipine; Nicotinic Acids; Nifedipine; Osmolar Concentration; Osteoclasts; Oxadiazoles; Rats; Whales | 1994 |
Calcium channel blocking properties of SM-6586 in rat heart and brain as assessed by radioligand binding assay.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Brain; Calcium Channel Blockers; Dihydropyridines; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Oxadiazoles; Potassium; Radioligand Assay; Rats; Rats, Wistar; Tritium; Vasoconstriction | 1993 |
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluorescent Dyes; Isomerism; Isradipine; Kinetics; Nicotinic Acids; Nifedipine; Nitrendipine; Oxadiazoles; Rabbits | 1997 |