isradipine has been researched along with dihydropyridines in 291 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (15.46) | 18.7374 |
| 1990's | 227 (78.01) | 18.2507 |
| 2000's | 17 (5.84) | 29.6817 |
| 2010's | 2 (0.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atkinson, J; Capdeville-Atkinson, C; Chillon, JM; Henrion, D | 1 |
| Hug, H; Marmé, D; Straub, P; Woscholski, R; Zgaga-Griesz, A | 1 |
| Caricati-Neto, A; Castillo, CJ; García, AG; Jurkiewicz, A; Jurkiewicz, NH; Lafayette, S; Sette, M | 1 |
| Christen, MO; Feron, O; Godfraind, T; Wibo, M | 1 |
| Blanck, TJ; Drenger, B; Heitmiller, ES; Quigg, M | 1 |
| Blanck, TJ; Fiskum, G; Hoehner, PJ; Rosenthal, RE; Roy, R | 1 |
| Amery, AK; Bielen, EC; Fagard, RH; Lijnen, PJ; Tjandra-Maga, TB; Verbesselt, R | 1 |
| Epstein, M; Forster, H; Goligorsky, MS; Iijima, K; Landry, DW; Takenaka, T | 1 |
| Fekete, Z; Liu, J; Slomiany, A; Slomiany, BL; Yao, P | 1 |
| Inagaki, O; Kato, Y; Kimura, R; Matsuoka, Y; Yamada, S | 1 |
| Czyrak, A; Dooley, DJ; Jones, GH; Robbins, TW | 1 |
| Mironneau, J | 2 |
| Gałewski, S; Kossut, M; Pomorski, P; Skangiel-Kramska, J | 1 |
| Araie, E; Miwa, K; Miyagi, Y; Sasayama, S | 1 |
| Coronado, R; el-Hayek, R; Hogan, K; Parness, J; Valdivia, HH | 1 |
| Bick, IR; Felix, JP; Garcia, ML; Kaczorowski, GJ; King, VF; Shevell, JL; Slaughter, RS | 1 |
| Fekete, Z; Liu, J; Murty, VL; Slomiany, A; Slomiany, BL | 1 |
| Kumar, A; Schliebs, R | 1 |
| Schechter, MD | 1 |
| Meluzín, J; Novák, M | 1 |
| Balazovjech, I; Dzúrik, R; Fet'kovská, N; Kvasnicka, J; Lupínek, Z; Mayer, O; Pidrman, V; Widimský, J | 1 |
| Goldmann, S; Stoltefuss, J; Triggle, DJ; Zheng, W | 1 |
| Arnaudeau, S; Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I; Yamamoto, T | 1 |
| García, AG; López, MG; Shukla, R; Wakade, AR | 1 |
| Delonca, J; Kipfer, P; Righetti, A | 1 |
| Bosse, E; Bottlender, R; Flockerzi, V; Hescheler, J; Hofmann, F; Kleppisch, T; Welling, A | 1 |
| Creager, MA; Cutler, SS; Dzau, VJ; Hirsch, AT; Levenson, DJ | 1 |
| Bond, MG; Borhani, NO; Brugger, SB; Craven, TE; Flack, J; Khoury, S; Miller, ST; Schnaper, HW | 1 |
| Fitscha, P; Sinzinger, H | 1 |
| Chou, TC; Ding, YA; Han, CL; Lai, WY; Shiao, MF | 2 |
| Bara, L; Bogaert, M; De Keyser, P; Degaute, JP; Hermans, L; Lanssiers, P; Rorive, G; Six, R; Westelinck, KJ | 1 |
| Clement, DL; D'Hont, G; De Keyser, P; Hermans, L; Meurant, JP; Rorive, G; Westelinck, KJ | 1 |
| Correa-Nunes, A; Mariano-Pego, G; Pereira-Miguel, JM; Rocha-Gonçalves, F | 1 |
| Armaganijan, D; Batlouni, M; Ghorayeb, N; Magliano, MF | 1 |
| Atilgan, D; Cubukçu, A; Eren, N; Gören, T; Koylan, N; Meriç, M | 1 |
| Holmes, D; Moullet, C | 1 |
| Cléroux, J; Kouamé, N; Lacourcière, Y; Marshall, A; Yardley, C | 1 |
| Bräutigam, M; Rüddel, H; Schächinger, H; Schmieder, R; Schulte, W; Welzel, D | 1 |
| Faraggi, D; Laszt, A; Viskoper, JR; Yaskil, E | 1 |
| Lotaif, L; Plavnik, F; Portela, JE; Ramos, OL; Saragoça, MA; Ventura, RP | 1 |
| Borbás, S; Lengyel, M; Török, E; Zorándi, A | 1 |
| Burger, KJ; Distler, GA; Gross, P; Koppenhagen, K; Welzel, D; Wudel, E | 2 |
| Dardamanis, M; Elisaf, M; Pappas, M; Sferopoulos, G; Siamopoulos, KC | 1 |
| Barroso, I; da Silva, A; Fagundes, VG; Francischetti, EA | 1 |
| Rosenfeld, JB; Wittenberg, C | 1 |
| Grunewald, C; Lunell, NO; Nisell, H | 1 |
| Babcock, DF; Corron, ME; Florman, HM; Kim, TD | 1 |
| Evenou, JP; Hof, A; Hof, RP; Rüegg, PC; Umemura, K | 1 |
| Liu, J; Slomiany, A; Slomiany, BL | 1 |
| Ekman, K; Harjula, K; Hartikainen, M; Helin, M; Inkovaara, J; Kataja, M; Luomanmäki, K; Viikari, J | 1 |
| Casley, DJ; Daly, MJ; Gu, XH; Nayler, WG; Ou, RC | 1 |
| Colombo, G; Fadda, F; Garau, B; Gessa, GL | 1 |
| David, D; Loria, Y; Ruegg, PC | 1 |
| Angelo, HR; Christensen, HR; Skajaa, K | 1 |
| Angelberger, P; Gerakakis, A; Keiler, A; Lupattelli, G; Pirich, C; Sinzinger, H; Virgolini, I | 1 |
| Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Calcagnetti, DJ; Schechter, MD | 1 |
| Anjichi, GM; Lore, W | 1 |
| Donatsch, P; Ettlin, RA; Prentice, DE; Qureshi, S; Siegel, RA | 1 |
| Catalano, M; Di Perri, T; Galimberti, P; Libretti, A; Milani, M; Scandale, G; Tomasini, M | 1 |
| Mason, RP; Moisey, DM; Shajenko, L | 1 |
| Fitscha, P; O'Grady, J; Rauscha, F; Sinzinger, H; Virgolini, I | 1 |
| Ebersole, BJ; Molinoff, PB | 2 |
| Cléroux, J; Coulombe, D; Lacourcière, Y; Marshall, A; Yardley, C | 1 |
| Andersson, OK; Hedner, T; Karlberg, B; Persson, B; Wysocki, M | 1 |
| Rudin, M; Sauter, A | 2 |
| Bladen, C; Dunn, SM | 2 |
| Abrams, AP; Black, HR; Hamilton, BP; Hamilton, JH; Isaacsohn, JL; Kochar, MS; Lewin, AJ; MacCarthy, EP; Madias, NE; Stein, GH | 1 |
| Christensen, HR; Galløe, AM; Graudal, N; Storm, T; Thamsborg, G | 1 |
| Rockstroh, J; Rüddel, H; Schächinger, H; Schlebusch, H; Schmieder, RE; Schulte, W | 1 |
| Akimoto, T; Ichida, S; Kishino, H; Masada, A; Wada, T; Yoshioka, T | 1 |
| Fratta, W; Gessa, GL; Kuzmin, A; Martellotta, MC; Zvartau, E | 1 |
| Meehan, SM; Schechter, MD | 1 |
| Feldt-Rasmussen, B; Jensen, T; Nørgaard, K | 1 |
| Fitscha, P; Keiler, A; O'Grady, J; Rauscha, F; Sinzinger, H | 1 |
| Hof, RP | 1 |
| Bang, L; Mellemkjaer, S; Nielsen-Kudsk, F | 1 |
| Lopez, LM; Santiago, TM | 1 |
| Marone, C; Schönholzer, K | 1 |
| Glossmann, H; Haase, H; Holtzhauer, M; Striessnig, J; Vetter, R | 1 |
| Araki, T; Hara, H; Kato, H; Kogure, K | 1 |
| Bers, DM; Hryshko, LV; Lew, WY | 1 |
| Catterall, WA; Murphy, BJ; Striessnig, J | 1 |
| Bravo, G; Godfraind, T; Wibo, M | 1 |
| Grahame-Smith, DG; Silverstone, PH | 1 |
| Bauer, JA; Fung, HL; Gopalakrishnan, M; Kwon, YW; Rutledge, A; Triggle, DJ | 1 |
| Chou, MY; Shibuya, T; Watanabe, Y | 1 |
| Lacerda, AE; Rampe, D | 1 |
| Ikeda, S; Nagao, T; Oka, J | 1 |
| Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I | 1 |
| Araki, T; Kato, H; Kogure, K; Saito, T | 1 |
| Crouzel, C; Syrota, A | 1 |
| Chan, TY; Woo, J | 1 |
| Galletti, F; Rutledge, A; Triggle, DJ | 1 |
| Battaini, F; Bergamaschi, S; Govoni, S; Meucci, O; Parenti, M; Schettini, G; Trabucchi, M | 1 |
| Naitoh, T; Sugimoto, T; Toyo-Oka, T | 1 |
| Abraham, C; Aptel, H; Lombet, A; Nagel, N; Peglion, JL; Randle, JC; Renaud, JF | 1 |
| Lory, P; Schultz, D; Schwartz, A; Varadi, G; Varadi, M | 1 |
| de Pascual, R; Gandía, L; García, AG; López, MG; Michelena, P | 1 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Hescheler, J; Scherübl, H | 1 |
| Lüscher, TF; Waeber, B | 1 |
| Fitscha, P; Hitzenberger, G; Meisner, W | 1 |
| Bond, MG; Borhani, NO; Buckalew, V; Canossa-Terris, M; Gibbons, ME; Sowers, JR; Worthy, AJ | 1 |
| Abreu, P; Ajzen, H; Plavnik, F; Portela, JE; Ramos, OL; Saragoça, MA; Vanneta, A; Ventura, R | 1 |
| Dzurik, R; Fedelesova, V; Fetkovska, N; Sebekova, K | 1 |
| Gleerup, G; Hedner, T; Hjørting Hansen, E; Winther, K | 1 |
| Garoff, L; Grunewald, C; Lunell, NO; Nisell, H; Nylund, L; Sarby, B; Thornström, S | 1 |
| Botelho, MA; Correia, JM; Mariano-Pego, G; Rocha-Gonçalves, F; Viegas, J | 1 |
| Erkinjuntti, M; Kantola, I; Mansury, L; Rauhala, E | 1 |
| Dahlöf, B; Eggertsen, R; Hansson, L; Jern, S; Kullman, S; Scherstén, B; Sivertsson, R; Sörensen, S | 1 |
| Farragi, D; Laszt, A; Viskoper, JR | 1 |
| Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A | 1 |
| Hawthorn, M; Triggle, DJ; Zheng, W | 1 |
| de Ree, MM; Gähwiler, BH; Knot, HJ; Rüegg, UT | 1 |
| Drímal, J | 1 |
| Bezáková, G; Krizanová, O; Lehotský, J; Mézesová, V | 1 |
| Fujimoto, M; Mihara, S | 1 |
| Brunát, J; Cepelák, V; Mádle, A; Smíd, J; Vainer, J | 1 |
| Leary, WP; Maharaj, B; Van der Byl, K | 1 |
| Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Siarey, RJ; Whittington, MA | 1 |
| Dartayet, B; Edouard, A; Ruegg, C; Samii, K | 1 |
| Christensen, KL | 1 |
| Galløe, AM; Graudal, N; Nielsen, OJ | 1 |
| Berg, KJ; Endresen, L; Fauchald, P; Hartmann, A; Holdaas, H; Pran, T; Solbu, D | 1 |
| Martinez, F; Pirson, Y; van Ypersele de Strihou, C; Wallemacq, P | 1 |
| Berg, KJ; Bergan, S; Endresen, L; Holdaas, H; Pran, T; Sinding-Larsen, B | 1 |
| Balkan, A; Ertan, M; Renaud, JF; Rübseman, K; Saraç, S; Uma, S | 1 |
| Godfraind, T; Morel, N; Salomone, S; Wibo, M | 1 |
| De Abajo, F; Sánchez-García, P; Serrano-Castro, MA | 1 |
| Chodakowska, J; Feltynowski, T; Januszewicz, W; Lapiński, M; Wocial, B | 1 |
| Amenta, F; Ferrante, F | 1 |
| Hescheler, J; Scherübl, H; Schultz, G | 1 |
| Garcia, AG; Jurkiewicz, A; Jurkiewicz, NH; Smaili, SS | 1 |
| Gonçalves, FR; Miguel, JM; Nunes, AC; Pêgo, GM | 1 |
| Celentano, A; de Divitiis, O; de Simone, G; Galderisi, M; Garofalo, M; Mureddu, GF; Tammaro, P | 1 |
| Ebata, H; Mitsuhashi, T; Natsume, T; Yaginuma, T | 1 |
| Boer, R; Boss, H; Eltze, M; Flockerzi, D; Sanders, KH; Ulrich, WR | 1 |
| Rampe, D; Schilling, WP; Zaher, MC | 1 |
| Edwards, WD; Lefler, BJ; Natale, NR; Palmer, RB; Triggle, DJ | 1 |
| Galletti, F; Luchowski, E; Triggle, DJ | 1 |
| Ebata, H; Johnson, JD; Mills, JS; Nemcek, K | 1 |
| Lemaire, S; Murphy, BJ; Rogers, CA; Sunahara, RK; Tuana, BS | 1 |
| Glossmann, H; Knaus, HG; Romanin, C; Scheffauer, F; Schindler, HG | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Ahlijanian, MK; Catterall, WA; Westenbroek, RE | 1 |
| Cross, AJ; Davies, EM; Green, AR; Little, HJ; Whittington, MA | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Brown, AM; Brush, K; Hamilton, SL; Schwartz, A; Yatani, A | 1 |
| Holck, M; Osterrieder, W | 1 |
| Artalejo, CR; Fonteriz, RI; Gandia, L; García, AG; Lopez, MG | 1 |
| Hofmann, F; Nastainczyk, W; Sieber, M; Wernet, W; Zubor, V | 1 |
| Froehner, SC; Morton, ME | 1 |
| Johnson, DF; Kuo, TH; Tsang, W; Wiener, J | 1 |
| Abram, A; Baginski, T; Banning, J; Rao, V | 1 |
| Askanas, V; Desnuelle, C; Engel, WK | 1 |
| Lamb, GD; Walsh, T | 1 |
| Kokubun, S; Porzig, H; Prod'hom, B; Reuter, H | 1 |
| Krizanová, O; Orlický, J; Zachar, J | 1 |
| Chaumet-Riffaud, P; Lemaire, M; Pinquier, JL; Tillement, JP; Urien, S | 1 |
| Beam, KG; Knudson, CM | 1 |
| Massieu, L; Tapia, R | 1 |
| Dunn, SM | 2 |
| Brisac, AM; Lacolley, P; Laurent, S; Legrand, M; Schmitt, H; Tsoucaris-Kupfer, D | 1 |
| Borges, R; Cárdenas, AM; Esteban, C; García, AG; Montiel, C | 1 |
| Dillon, JS; Gu, XH; Nayler, WG | 1 |
| Buisson, N; Gourdji, D; Laverrière, JN; Martial, JA; Richard, JL; Tixier-Vidal, A | 1 |
| Castillo, CJ; Fonteríz, RI; García, AG; López, MG; Rosenheck, K | 1 |
| Dodd, PR; Gundlach, AL; Harper, CG; Johnston, GA; Kril, JJ | 1 |
| Ehrhardt, JD; Quennedey, MC; Rouot, B; Schwartz, J; Welsch, M | 1 |
| Matlib, MA | 1 |
| Bisenieks, EA; Dooley, D; Dubur, GJ; Kimenis, AA; Lukevics, EJ; Makarova, NR; Osswald, H; Uldrikis, JR; Veveris, MM; Weinheimer, G | 1 |
| Coronado, R; Valdivia, HH | 1 |
| Rutledge, A; Triggle, DJ; Wei, XY | 1 |
| Ferrante, J; Rutledge, A; Triggle, DJ; Wei, XY; Zhong, Q | 1 |
| Boer, R; Glossmann, H; Grassegger, A; Schudt, C | 1 |
| Hudecová, S; Krizanová, O; Orlický, J; Zachar, J | 1 |
| Godfraind, T; Morel, N | 1 |
| Alvarez, RM; Brush, KL; Fill, M; Hamilton, SL; Hawkes, MJ; Schilling, WP; Stefani, E | 1 |
| Glossmann, H; Grassegger, A; Knaus, HG; Striessnig, J; Weiler, M | 1 |
| Brown, AM; Caffrey, JM; Rampe, D; Schneider, MD | 1 |
| Bode-Greuel, KM; Singer, W | 1 |
| Garcia, L; Lazdunski, M; Rieger, F; Romey, G | 1 |
| Quirion, R | 1 |
| Gerard, P; Huchet, AM; Huguet, F; Narcisse, G | 1 |
| Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H | 1 |
| Schilling, WP | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Lazdunski, M | 1 |
| Reynolds, IJ; Snowman, AM; Snyder, SH | 1 |
| Campbell, KP; Imagawa, T; Leung, AT; Sharp, AH | 1 |
| Liu, J; Rutledge, A; Triggle, DJ | 1 |
| Sze, PY; Yu, BH | 1 |
| Canda, A; Sze, PY; Yu, BH | 1 |
| Artalejo, CR; Cillero, FJ; de Casa-Juana, MF; de Pascual, R; García, AG; González-Morales, MA; López, MG; Priego, J; Sunkel, C; Villarroya, M | 1 |
| Artalejo, AR; de la Fuente, MT; del Valle, M; Gandía, L; García, AG; Montiel, C; Vinet, R | 1 |
| Beam, KG; Dirksen, RT | 1 |
| Alajarin, R; Alvarez-Builla, J; Fau de Casa-Juana, M; Fonseca, I; Pastor, M; Priego, J; Sanz-Aparicio, J; Statkow, PR; Sunkel, C; Vaquero, JJ | 1 |
| Rao, MR; Xu, Y | 1 |
| Hattori, K; Maruyama, K; Nagatomo, T; Qu, YL; Sugiyama, K; Takamizawa, C; Watanabe, K | 1 |
| Audy, MC; Bonnin, M; Bouali-Benazzouz, R | 1 |
| Galiano, A; Leprêtre, N; Mironneau, C; Mironneau, J; Rakotoarisoa, L | 1 |
| Battaini, F; Bergamaschi, S; Govoni, S; Parenti, M; Trabucchi, M | 1 |
| Bangalore, R; Glossmann, H; Kass, RS; Kwan, YW; Lakitsh, M | 1 |
| Matsui, K; Miyakoda, G; Nakayama, N; Yabuuchi, Y | 1 |
| Hymel, LJ; Inscho, EW; Mayer, MB; Ruiz-Velasco, V | 1 |
| Baron, A; Leprêtre, N; Mironneau, J; Rakotoarisoa, L | 1 |
| Hayashi, T; Kato, H; Koshino, Y; Kutsumi, Y; Miyabo, S; Nakai, T; Oida, K | 1 |
| Chiavaroli, C; Guérineau, N; Mollard, P; Schlegel, W; Theler, JM; Vacher, P | 1 |
| Locher, R; Lupo, E; Vetter, W; Weisser, B | 1 |
| Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Ulicna, L | 2 |
| Bourachot, ML; Crouzel, C; Fuseau, C; Syrota, A; Valette, H | 1 |
| Arnaudeau, S; Galiano, A; Lepretre, N; Mironneau, C; Mironneau, J; Rakotoarisoa, L | 1 |
| Bangalore, R; Liu, J; Rutledge, A; Triggle, DJ | 1 |
| Do Carmo, LG; Jurkiewicz, A; Jurkiewicz, NH; Lafayette, SS; Martini, LC; Nunes, SH; Wanderley, AG | 1 |
| Ganunis, TF; Helfaer, MA; Hoehner, PJ; Kirsch, JR; Murphy, MT; Traystman, RJ | 1 |
| Gayman, KJ; Lachnit, WG; Pessah, IN; Phillips, M | 1 |
| Cagnotto, A; Gaviraghi, G; Mennini, T; Micheli, D; Ratti, E; Taddei, C; Trist, D; Uslenghi, A | 1 |
| Hasegawa, T; Morita, S; Nabeshima, T; Teraoka, T; Yamada, K | 1 |
| Louis, CF; Mickelson, JR; Roghair, T | 1 |
| Adachi, I; Nakajima, M; Ueda, M | 1 |
| Lombet, A; Spedding, M | 1 |
| Maniwa, T; Miyagishi, A; Nagatomo, T; Qu, YL; Sugiyama, K | 1 |
| Fekete, Z; Liu, J; Slomiany, A; Slomiany, BL | 1 |
| Hescheler, J; Kleppisch, T; Krautwurst, D; Raue, F; Scherübl, H; Zink, A | 1 |
| Boksa, P; Quirion, R; Sen, AP | 1 |
| Aoudjit, F; Dupuis, G; Payet, MD; Ricard, I | 1 |
| Godfraind, T; Salomone, S | 1 |
| Glossmann, H; Grabner, M; Hering, S; Striessnig, J; Wang, Z | 1 |
| Cheung, JY; Moore, RL; Tillotson, DL; Zhang, XQ | 1 |
| Block, LH; Nauck, M; Rödler, S; Roth, M; Tamm, M | 1 |
| Catterall, WA; Peterson, BZ; Tanada, TN | 1 |
| Jacobson, KA; Jiang, JL; Melman, N; Olah, ME; Stiles, GL; van Rhee, AM | 1 |
| Graziani, F; Ratti, E; van Amsterdam, FT | 1 |
| Akopov, SE | 1 |
| Gilar, M; Tesarová, E; Uhrová, M | 1 |
| Borea, PA; Cerbai, E; Gessi, S; Guerra, L; Mugelli, A | 1 |
| Hamman, BN; Thomas, MJ; Tibbits, GF | 1 |
| Guerrier, P; Leclerc, C; Moreau, M | 1 |
| Birnbaumer, L; Suh-Kim, H; Wei, X | 1 |
| Guerrier, P; Krantic, S; Tomkowiak, M | 1 |
| Abu Khoudoud, OR; Bikhazi, AB; Bitar, KM; el-Kasti, MM; Ibrahim, MZ; Kreydiyyeh, SI; Saleh, RS | 1 |
| Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z | 1 |
| Brauns, T; Glossmann, H; Haugland, RP; Kimball, SD; Prinz, H; Striessnig, J | 1 |
| Blanck, TJ; Curtis, WE; Gardner, TJ; Quigg, M; Yasukochi, S | 1 |
| Crouzel, C; Dollé, F; Duval, R; Fuseau, C; Hinnen, F; Péglion, JL; Valette, H | 1 |
| Catterall, WA; Johnson, BD; Korach, KS; Rubanyi, GM; Scheuer, T; Zheng, W | 1 |
| Campbell, KP; De Waard, M; Felix, R; Gurnett, CA | 1 |
| Donetti, E; Fumagalli, R; Paoletti, R; Soma, MR | 1 |
| Akira, T; Iwamoto, M; Kagitani, Y; Nakamura, N; Shinyama, H; Uchida, T; Yamanaga, K | 1 |
| Hofmann, F; Ito, H; Klugbauer, N | 1 |
| Bollo-Dragnic, S; Díaz-Araya, G; Letelier, ME; Marín-Catalán, R; Núñez-Vergara, LJ; Pino, L; Squella, JA | 1 |
| Kanaya, N; Kawana, S; Kimura, H; Matsumoto, M; Miyamoto, A; Namiki, A; Ohshika, H; Tsuchida, H | 1 |
| Frick, GP; Gaur, S; Goodman, HM; Morton, ME | 1 |
| Grabner, M; Hering, S; Kraus, RL; Ostler, D; Striessnig, J | 1 |
| An, RH; Hofmann, F; Ito, H; Kass, RS; Klugbauer, N; Lacinová, L; Triggle, D; Xia, J | 1 |
| Hofmann, F; Hu, M; Klugbauer, N; Lacinová, L | 1 |
| Grant, KA; Green, KL | 1 |
| Ait-Daoud, N; Bordnick, PS; Johnson, BA; Roache, JD | 1 |
| Kimura, R; Uchida, S; Urayama, A; Yamada, S | 1 |
| Gonon, A; Nordlander, M; Rydén, L; Segawa, D; Sjöquist, PO; Wang, QD | 1 |
| Ait-Daoud, N; Johnson, BA; Wells, LT | 1 |
| Hofmann, F; Klugbauer, N; Lacinová, L | 1 |
| Antepohl, W; Haaf, O; Herzig, S; Huber, I; Matthes, J; Striessnig, J | 1 |
| Deguchi, Y; Kimura, R; Uchida, S; Yamada, S; Yamamoto, M | 1 |
| Chang, AS; Chang, SM; Choobineh, E; Collins, PL; Lundgren, DW; Moore, JJ | 1 |
| Carroll, EM; Collins, PL; Gianopoulos, JG | 1 |
| Glossmann, H; Mitterdorfer, J; Striessnig, J; Wappl, E | 1 |
| Bidet, M; Martial, S; Martin, D; Melendez, E; Namorado, MD; Poujeol, C; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M; Valencia, L | 1 |
| Dolphin, AC; Nürnberg, B; Plant, TD; Scholze, A | 1 |
| Ait-Daoud, N; Devous, MD; Johnson, BA; Ruiz, P | 1 |
| Kimura, R; Nakajima, M; Uchida, S; Yamada, S | 1 |
| Grabner, M; Heinzle, T; Hoda, JC; Koschak, A; Reimer, D; Striessnig, J; Walter, D | 1 |
| Adachi-Akahane, S; Ichijo, H; Nagao, T; Yamaguchi, S; Yoshioka, K; Zhorov, BS | 1 |
| Hofmann, F; Lee, M; Wegener, JW | 1 |
| El Bardai, S; Hamaide, MC; Lyoussi, B; Morel, N; Quetin-Leclercq, J; Wibo, M | 1 |
| Fujimura, S; Hattori, T; Hirai, K; Wang, P | 1 |
| Hoda, JC; Huber, IG; Sinnegger-Brauns, MJ; Striessnig, J; Walter-Bastl, D; Wappl-Kornherr, E | 1 |
| Guzman, JN; Ilijic, E; Surmeier, DJ | 1 |
| Ding, WG; Dubel, S; Mangoni, ME; Matsuura, H; Mesirca, P; Striessnig, J; Toyoda, F | 1 |
6 review(s) available for isradipine and dihydropyridines
| Article | Year |
|---|---|
Antiatherosclerotic actions of isradipine.
Topics: Arteriosclerosis; Calcium Channel Blockers; Dihydropyridines; Humans; Isradipine; Lipid Metabolism | 1992 |
Isradipine--another calcium-channel blocker for the treatment of hypertension and angina.
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Dihydropyridines; Drug Interactions; Humans; Hypertension; Isradipine; Kidney | 1992 |
New drugs for hypertension--variations on old themes.
Topics: Amlodipine; Antihypertensive Agents; Delayed-Action Preparations; Dihydropyridines; Doxazosin; Humans; Hypertension; Isradipine; Nifedipine; Prazosin; Verapamil | 1991 |
Calcium channels in the heart. Properties and modulation by dihydropyridine enantiomers.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Heart; Humans; Ion Channels; Isradipine; Nicotinic Acids; Oxadiazoles; Stereoisomerism | 1988 |
Calcium currents in embryonic and neonatal mammalian skeletal muscle.
Topics: Animals; Animals, Newborn; Barium; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electrophysiology; Embryo, Mammalian; Embryo, Nonmammalian; Ion Channels; Isradipine; Muscles; Oxadiazoles; Stereoisomerism | 1988 |
Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonists.
Topics: Brain Ischemia; Calcium Channel Blockers; Cocaine-Related Disorders; Dihydropyridines; Humans; Isradipine; Stroke; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Vasospasm, Intracranial | 2001 |
50 trial(s) available for isradipine and dihydropyridines
| Article | Year |
|---|---|
Comparison of the effects of isradipine and lisinopril on left ventricular structure and function in essential hypertension.
Topics: Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Echocardiography, Doppler; Enalapril; Female; Follow-Up Studies; Heart Ventricles; Humans; Hypertension; Isradipine; Lisinopril; Male; Random Allocation; Regression Analysis; Ventricular Function, Left | 1992 |
[Comparison of the effects of diltiazem and isradipine in adrenergic beta receptor blockade in patients with stable angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Heart Rate; Humans; Isradipine; Male; Metipranolol; Middle Aged | 1992 |
[Multicenter study of isradipine in the treatment of hypertension].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Pindolol | 1992 |
Effects of oral isradipine on left ventricular function at rest and during exercise in patients with stable chronic angina: a double-blind, placebo-controlled crossover study.
Topics: Adult; Aged; Angina Pectoris; Angiocardiography; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Echocardiography; Electrocardiography; Exercise; Female; Gated Blood-Pool Imaging; Heart; Heart Rate; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Rest; Ventricular Function, Left | 1992 |
Effect of isradipine on cardiopulmonary baroreflex function, regional blood flow, and vascular responsiveness in hypertensive patients.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Isradipine; Male; Middle Aged; Norepinephrine; Pressoreceptors; Reflex; Regional Blood Flow | 1992 |
MIDAS: hypertension and atherosclerosis. A trial of the effects of antihypertensive drug treatment on atherosclerosis. MIDAS Research Group.
Topics: Antihypertensive Agents; Arteriosclerosis; Dihydropyridines; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Isradipine; Male | 1992 |
Tolerability of isradipine in the treatment of mild-to-moderate hypertension in general practice: a large-scale surveillance study.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Drug Tolerance; Humans; Hypertension; Isradipine | 1992 |
Long-term (2-year) isradipine data in the treatment of mild-to-moderate hypertension.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Humans; Hypertension; Isradipine | 1992 |
Isradipine in the treatment of mild-to-moderate hypertension in Portugal.
Topics: Adolescent; Adult; Aged; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Portugal | 1992 |
Clinical efficacy and tolerability of isradipine in the treatment of mild-to-moderate hypertension in young and elderly patients.
Topics: Adult; Age Factors; Aged; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Tolerance; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged | 1992 |
Metabolic, hematological, and cardiac effects of long-term isradipine treatment in mild-to-moderate essential hypertension.
Topics: Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Isradipine; Lipids; Male; Middle Aged | 1992 |
Clinical equivalence of once-daily administration of a modified-release formulation of isradipine and twice-daily administration of the standard formulation. Multicentre Study Group.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Double-Blind Method; Female; Humans; Isradipine; Male; Middle Aged | 1992 |
Pharmacological modulation of stress-induced cardiovascular hyperreactivity in essential hypertension.
Topics: Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Hemodynamics; Humans; Hypertension; Isradipine; Male; Metoprolol; Stress, Psychological | 1992 |
Does isradipine exert a special early-morning blood pressure-lowering effect?
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Isradipine; Male; Middle Aged | 1992 |
Isradipine in the treatment of hypertensive crisis in ambulatory patients.
Topics: Administration, Sublingual; Ambulatory Care; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Isradipine | 1992 |
Regression of cardiac hypertrophy in hypertensive patients by long-term treatment with isradipine.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Pindolol; Ventricular Function, Left | 1992 |
Hemodynamic effects of isradipine and nifedipine in chronic sustained hypertension.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Isradipine; Middle Aged; Nifedipine | 1992 |
Effects of isradipine on hypertension and renal hemodynamics.
Topics: Adult; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Isradipine; Male; Middle Aged; Renal Circulation | 1992 |
Effects of long-term administration of isradipine on renal hemodynamics and sodium metabolism.
Topics: Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Hemodynamics; Humans; Isradipine; Renal Circulation; Sodium | 1992 |
Long-term antihypertensive and renal effects of isradipine in hypertensive patients with normal and reduced renal function.
Topics: Administration, Oral; Adult; Aged; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Isradipine; Kidney; Kidney Function Tests; Middle Aged | 1992 |
Effect of isradipine on responses to standardized physical stress tests in hypertension of pregnancy.
Topics: Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Exercise Test; Female; Heart Rate; Humans; Hypertension; Isometric Contraction; Isradipine; Physical Stimulation; Pregnancy; Pregnancy Complications, Cardiovascular | 1992 |
Efficacy and tolerability of isradipine and metoprolol in treatment of hypertension: the Finnish Isradipine Study in Hypertension (FISH).
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Hypertension; Isradipine; Male; Metoprolol; Middle Aged | 1992 |
Isradipine for the treatment of hypertension following coronary artery bypass graft surgery: a randomized trial versus sodium nitroprusside.
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Artery Bypass; Dihydropyridines; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Nitroprusside; Postoperative Complications | 1992 |
Clinical studies on isradipine in the management of adult hypertensive patients at Moi University Teaching Hospital, Eldoret, Kenya.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Female; Heart Rate; Hospitals, University; Humans; Hypertension; Isradipine; Kenya; Male; Middle Aged | 1992 |
Isradipine in the treatment of peripheral occlusive vascular disease of the lower limbs: a pilot study.
Topics: Antihypertensive Agents; Blood Pressure; Dihydropyridines; Double-Blind Method; Humans; Intermittent Claudication; Isradipine; Middle Aged; Pain; Pilot Projects; Time Factors | 1992 |
Antihypertensive and hemodynamic effects of calcium channel blockade with isradipine after acute exercise.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Double-Blind Method; Exercise; Hemodynamics; Humans; Hypertension; Isradipine; Middle Aged; Placebos; Time Factors; Vascular Resistance | 1992 |
Calcium antagonism in essential hypertension: effect on renal haemodynamics and microalbuminuria.
Topics: Albuminuria; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Hemodynamics; Humans; Hypertension; Isradipine; Male; Middle Aged; Multivariate Analysis; Renal Circulation; Rheology | 1992 |
A comparison of the safety of therapeutically equivalent doses of isradipine and diltiazem for treatment of essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Isradipine; Male; Middle Aged | 1992 |
Atrial natriuretic peptide (ANP) in chronic obstructive pulmonary disease (COPD): the relationship between plasma ANP and lung function. Effects of exercise and of the calcium antagonist, isradipine, on plasma ANP. A randomised, double-blind, placebo-cont
Topics: Atrial Natriuretic Factor; Calcium Channel Blockers; Dihydropyridines; Humans; Isradipine; Lung; Lung Diseases, Obstructive; Physical Exertion | 1992 |
Impact of antihypertensive therapy with isradipine and metoprolol on early markers of hypertensive nephropathy.
Topics: Antihypertensive Agents; Dihydropyridines; Double-Blind Method; Humans; Hypertension; Isradipine; Kidney Failure, Chronic; Male; Metoprolol; Middle Aged; Proteinuria | 1992 |
A high incidence of cough associated with combination therapy of hypertension with isradipine and lisinopril in Chinese subjects.
Topics: Adult; Aged; Antihypertensive Agents; Cough; Dihydropyridines; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Isradipine; Lisinopril; Male; Middle Aged | 1991 |
Effect of isradipine on platelet aggregation and oxygen free radicals in hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Dihydropyridines; Female; Free Radicals; Humans; Hydrogen Peroxide; Hypertension; Isradipine; Male; Middle Aged; Neutrophils; Oxygen; Platelet Aggregation; Platelet Aggregation Inhibitors; Superoxides | 1991 |
Calcium antagonists as first-line therapy in hypertension: results of the Swiss Isradipine Study. Swiss Hypertension Society.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Isradipine; Middle Aged; Switzerland | 1991 |
Evaluation of isradipine and captopril alone or in combination for the treatment of hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Captopril; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged | 1991 |
The Multicenter Isradipine/Diuretic Atherosclerosis Study: a study of the antiatherogenic properties of isradipine in hypertensive patients. MIDAS Research Group.
Topics: Adult; Aged; Arteriosclerosis; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Isradipine; Male; Middle Aged; Ultrasonography | 1991 |
Does antihypertensive therapy affect the natural protection against thrombosis?
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Fibrinolysis; Humans; Hypertension; Isradipine; Male; Middle Aged; Propranolol; Tissue Plasminogen Activator | 1991 |
First clinical experience with isradipine in the treatment of hypertension in Portugal.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Nifedipine; Portugal | 1991 |
Sleep disturbances in hypertension: a double-blind study between isradipine and metoprolol.
Topics: Adult; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Humans; Hypertension; Isradipine; Male; Metoprolol; Middle Aged; Monitoring, Physiologic; Respiration; Sleep Apnea Syndromes; Snoring | 1991 |
Swedish Isradipine Study in Hypertension: evaluation of quality of life, safety, and efficacy. SWISH Group.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Humans; Hypertension; Isradipine; Middle Aged; Prospective Studies; Quality of Life; Safety; Sweden | 1991 |
The antihypertensive action of isradipine in mild essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Double-Blind Method; Humans; Hypertension; Isradipine; Male; Middle Aged; Monitoring, Physiologic; Time Factors | 1991 |
Isradipine in the treatment of mild to moderate essential hypertension.
Topics: Antihypertensive Agents; Dihydropyridines; Humans; Hypertension; Isradipine; Male | 1991 |
The use of calcium antagonists to treat intra-operative hypertension--evaluation of efficacy and safety of a new dihydropyridine derivative, intravenous isradipine, during abdominal surgery.
Topics: Abdomen; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Drug Tolerance; Female; Heart Rate; Humans; Hypertension; Hypotension; Injections, Intravenous; Intraoperative Complications; Isradipine; Male; Middle Aged; Placebos; Safety; Time Factors | 1991 |
Erythropoietin in chronic obstructive pulmonary disease. Relationship between serum erythropoietin, blood hemoglobin and lung function--effect of the calcium antagonist isradipine on serum erythropoietin.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Erythropoietin; Forced Expiratory Volume; Hematocrit; Hemoglobins; Humans; Isradipine; Lung Diseases, Obstructive; Middle Aged; Respiratory Mechanics; Vital Capacity | 1991 |
Lack of effect of the calcium antagonist isradipine on cyclosporine pharmacokinetics in renal transplant patients.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Cyclosporine; Dihydropyridines; Drug Administration Schedule; Female; Humans; Isradipine; Kidney Transplantation; Male; Middle Aged | 1991 |
[The hemodynamic effects of isradipine and nifedipine in hypertension].
Topics: Adult; Blood Pressure; Cardiac Output; Dihydropyridines; Female; Heart; Heart Function Tests; Humans; Hypertension; Injections, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Propranolol; Stroke Volume | 1991 |
[Clinical trial with isradipine in the treatment of mild and moderate arterial hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Dihydropyridines; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Patient Satisfaction; Risk Factors; Sex Factors | 1991 |
Effects of dihydropyridines and their combination with aspirin on blood pressure and circadian platelet activity in patients with essential hypertension.
Topics: Adult; Aspirin; Blood Platelets; Blood Pressure; Circadian Rhythm; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Nitrendipine | 1994 |
Treatment of hypertension with dihydropyridine calcium antagonists and aspirin.
Topics: Adult; Aspirin; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Nitrendipine | 1994 |
Isradipine, a dihydropyridine-class calcium channel antagonist, attenuates some of d-methamphetamine's positive subjective effects: a preliminary study.
Topics: Adrenergic Agents; Adult; Affect; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Drug Antagonism; Female; Humans; Isradipine; Male; Methamphetamine; Middle Aged; Reinforcement, Psychology; Reward; Substance-Related Disorders | 1999 |
Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on D-methamphetamine-induced cognitive and physiological changes in humans.
Topics: Adult; Amphetamine-Related Disorders; Calcium Channel Blockers; Cardiovascular Physiological Phenomena; Cognition; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Female; Humans; Isradipine; Male; Methamphetamine; Middle Aged; Nootropic Agents | 2000 |
235 other study(ies) available for isradipine and dihydropyridines
| Article | Year |
|---|---|
Effect of chronic treatment with the calcium entry blocker, isradipine, on vascular calcium overload produced by vitamin D3 and nicotine in rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Calcium; Calcium Channel Blockers; Cholecalciferol; Dihydropyridines; Endothelium, Vascular; Heart Rate; Isradipine; Male; Mesenteric Arteries; Models, Biological; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Biochemical characterization of binding sites for dihydropyridine and omega-conotoxin in brain of adult chicken.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chickens; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Dihydropyridines; Isradipine; Kinetics; omega-Conotoxins; Peptides, Cyclic; Receptors, Neurotransmitter; Receptors, Nicotinic; Solubility | 1992 |
Low dihydropyridine receptor density in vasa deferentia of castrated rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Male; Membranes; Nifedipine; Orchiectomy; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Vas Deferens | 1992 |
Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Diltiazem; Ileum; In Vitro Techniques; Isradipine; Kinetics; Morpholines; Muscle, Smooth; Parasympatholytics; Rats; Receptors, Nicotinic; Saponins | 1992 |
Depression of calcium channel blocker binding to rat brain membranes by halothane.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Enflurane; Halothane; Isoflurane; Isradipine; Male; Rats; Rats, Inbred Strains | 1992 |
Alteration of voltage-dependent calcium channels in canine brain during global ischemia and reperfusion.
Topics: Animals; Binding Sites; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dihydropyridines; Dogs; Female; Isradipine; Nitrendipine; Reperfusion; Synaptosomes | 1992 |
Attenuation of endothelin effects by a chloride channel inhibitor, indanyloxyacetic acid.
Topics: Animals; Antihypertensive Agents; Arterioles; Calcium; Cells, Cultured; Chloride Channels; Dihydropyridines; Electrophysiology; Endothelins; Glycolates; Hydronephrosis; In Vitro Techniques; Isradipine; Membrane Proteins; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Renal Circulation; Vasoconstriction | 1992 |
Modulation of dihydropyridine-sensitive gastric mucosal calcium channels by GM1-ganglioside.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cell Membrane; Dihydropyridines; G(M1) Ganglioside; Gastric Mucosa; Isradipine; Lanthanum; Liposomes; Male; Osmolar Concentration; Phosphatidylcholines; Rats; Rats, Inbred Strains | 1992 |
A sustained occupancy in vivo of cardiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Blood Pressure; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Hypertension; Isradipine; Male; Myocardium; Nifedipine; Rats; Rats, Inbred SHR; Receptors, Nicotinic | 1992 |
Social isolation increases the density of [125I]omega-conotoxin GVIA binding sites in the rat frontal cortex and caudate nucleus.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Caudate Nucleus; Cell Membrane; Dihydropyridines; Female; Frontal Lobe; Hippocampus; Iodine Radioisotopes; Isradipine; Mollusk Venoms; omega-Conotoxin GVIA; Organ Specificity; Peptides, Cyclic; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Reference Values; Social Isolation | 1992 |
Transduction pathways for noradrenaline-induced modulation of calcium channels in vascular smooth muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Horses; In Vitro Techniques; Isradipine; Membranes; Microsomes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phosphatidylinositols; Protein Kinase C; Rats; Signal Transduction | 1992 |
Voltage-dependent L-type calcium channels in the development and plasticity of mouse barrel cortex.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Mice; Neuronal Plasticity; Nifedipine; Somatosensory Cortex; Tritium; Vibrissae | 1992 |
Effects of diltiazem and verapamil on (+)-PN 200-110 binding kinetics in dog cardiac membranes.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dogs; Female; In Vitro Techniques; Isradipine; Kinetics; Male; Myocardium; Receptors, Nicotinic; Temperature; Verapamil | 1992 |
Dantrolene and azumolene inhibit [3H]PN200-110 binding to porcine skeletal muscle dihydropyridine receptors.
Topics: Animals; Caffeine; Calcium Channels; Dantrolene; Dihydropyridines; Imidazoles; Isradipine; Malignant Hyperthermia; Muscle Relaxants, Central; Muscles; Oxazoles; Receptors, Cholinergic; Receptors, Nicotinic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Swine; Tritium | 1992 |
Bis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding site.
Topics: Alkaloids; Animals; Benzylisoquinolines; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluspirilene; Gallopamil; Isoquinolines; Isradipine; Kinetics; Molecular Conformation; Molecular Structure; Myocardium; Sarcolemma; Swine | 1992 |
Activation of dihydropyridine-sensitive parotid salivary gland calcium channels by epidermal growth factor.
Topics: Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Isradipine; Lanthanum; Liposomes; Male; Parotid Gland; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine | 1992 |
Postnatal laminar development of cholinergic receptors, protein kinase C and dihydropyridine-sensitive calcium antagonist binding in rat visual cortex. Effect of visual deprivation.
Topics: Age Factors; Animals; Autoradiography; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Nicotine; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cholinergic; Sensory Deprivation; Vision, Ocular; Visual Cortex | 1992 |
Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.
Topics: Alkaloids; Animals; Antipsychotic Agents; Calcium Channel Blockers; Dihydropyridines; Discrimination Learning; Discrimination, Psychological; Dopamine; Dose-Response Relationship, Drug; Isradipine; Male; Neurotransmitter Agents; Psychotropic Drugs; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Thiazepines; Tropanes | 1992 |
Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Drug Antagonism; Heart; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Nifedipine; Radioligand Assay; Rats | 1992 |
Effect of dihydropyridines on calcium channels in isolated smooth muscle cells from rat vena cava.
Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; In Vitro Techniques; Ion Channels; Isradipine; Muscle, Smooth, Vascular; Rats; Receptors, Nicotinic; Sodium Channels; Tetrodotoxin; Venae Cavae | 1992 |
A dihydropyridine-resistant component in the rat adrenal secretory response to splanchnic nerve stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adrenal Glands; Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Dihydropyridines; Drug Resistance; Electric Stimulation; Hexamethonium; Hexamethonium Compounds; Isradipine; Male; Neural Conduction; Nicotine; Potassium; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Splanchnic Nerves | 1992 |
Stable and functional expression of the calcium channel alpha 1 subunit from smooth muscle in somatic cell lines.
Topics: Animals; Base Sequence; Calcium Channel Blockers; Calcium Channels; CHO Cells; Cricetinae; Dihydropyridines; DNA; Ion Channel Gating; Isradipine; Kinetics; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Muscle, Smooth; Muscles; Oligodeoxyribonucleotides; Poly A; Polymerase Chain Reaction; Recombinant Proteins; Restriction Mapping; RNA; RNA, Messenger; Transfection | 1992 |
Antihypertensive treatment: prevention of cardiovascular disease and prevention of events. Satellite symposium to the 5th European Meeting on Hypertension. Milan, Italy, June 7-10, 1991.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Dihydropyridines; Humans; Isradipine | 1992 |
Effects of the calcium antagonist isradipine on 24-hour ambulatory blood pressure, platelet aggregation, and neutrophil oxygen free radicals in hypertension.
Topics: Aged; Blood Pressure; Blood Pressure Monitors; Calcium Channel Blockers; Dihydropyridines; Female; Free Radicals; Humans; Hypertension; Isradipine; Male; Middle Aged; Neutrophils; Oxygen; Platelet Aggregation; Platelet Aggregation Inhibitors | 1992 |
Postexercise reflex control of forearm vascular resistance during calcium antagonism with slow-release oral isradipine.
Topics: Administration, Oral; Adult; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Exercise; Forearm; Humans; Isradipine; Middle Aged; Reflex; Vascular Resistance | 1992 |
Activation of voltage-dependent calcium channels of mammalian sperm is required for zona pellucida-induced acrosomal exocytosis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acrosome; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cattle; Dihydropyridines; Exocytosis; Isradipine; Male; Mice; Nitrendipine; Sheep; Spermatozoa; Zona Pellucida | 1992 |
Effects of isradipine on plasma renin activity in sodium-loaded and -depleted conscious rabbits.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Furosemide; Heart Rate; Isradipine; Rabbits; Renin; Sodium; Sodium, Dietary | 1992 |
Platelet-derived growth factor activation of gastric mucosal calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Gastric Mucosa; Isradipine; Kinetics; Liposomes; Phosphorylation; Platelet-Derived Growth Factor; Rats; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor | 1992 |
Effect of age on endothelin-1 binding sites in rat cardiac ventricular membranes.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Calcium; Dihydropyridines; Endothelin-1; Endothelins; Female; Heart Ventricles; Isradipine; Membranes; Myocardium; Ouabain; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Endothelin; Sodium-Potassium-Exchanging ATPase | 1992 |
Isradipine and other calcium channel antagonists attenuate ethanol consumption in ethanol-preferring rats.
Topics: Alcohol Drinking; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ethanol; Isradipine; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Determination of isradipine and its pyridine metabolite in serum by capillary column gas chromatography with nitrogen-selective detection.
Topics: Calcium Channel Blockers; Chromatography, Gas; Dihydropyridines; Humans; Isradipine; Nitrogen; Pyridines; Reproducibility of Results | 1992 |
Concomitant aspirin treatment abolishes the antiatherosclerotic effects of the calcium channel blocker isradipine mediated by PGI2.
Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Aspirin; Calcium Channel Blockers; Cholesterol; Dihydropyridines; Epoprostenol; Humans; Hypercholesterolemia; Isradipine; Kinetics; Lipid Metabolism; Lipoproteins, LDL; Male; Rabbits | 1992 |
Evidence for the presence of regional differences in the calcium antagonist receptors in lower urinary tract smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Carbachol; Dihydropyridines; Drug Interactions; Female; Isradipine; Muscle Contraction; Muscle, Smooth; Nifedipine; Rabbits; Urinary Tract | 1992 |
Attenuation of drinking sweetened water following calcium channel blockade.
Topics: Animals; Calcium Channel Blockers; Cocaine; Dihydropyridines; Dose-Response Relationship, Drug; Drinking Behavior; Female; Injections, Intraventricular; Isradipine; Male; Rats; Rats, Inbred Strains; Reward; Taste | 1992 |
Mesulergine induced Leydig cell tumours, a syndrome involving the pituitary-testicular axis of the rat.
Topics: Animals; Dihydropyridines; Ergolines; Isradipine; Leydig Cell Tumor; Male; Pituitary Hormones; Rats; Rats, Inbred Strains; Syndrome; Testicular Hormones; Time Factors | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Isradipine improves platelet function in hypertensives.
Topics: Analysis of Variance; Antihypertensive Agents; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Epoprostenol; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Platelet Aggregation; Prostaglandin D2 | 1992 |
Identification of ascorbate as an endogenous substance that irreversibly inhibits binding of dihydropyridine calcium channel blockers.
Topics: Animals; Ascorbate Oxidase; Ascorbic Acid; Brain; Calcium Channel Blockers; Chromatography; Chromatography, High Pressure Liquid; Dihydropyridines; Iron; Isradipine; Male; Rats; Rats, Inbred Strains; Spectrophotometry; Ultraviolet Rays | 1992 |
Efficacy of isradipine in middle cerebral artery-occluded rats.
Topics: Animals; Arterial Occlusive Diseases; Cerebral Arteries; Dihydropyridines; Isradipine; Rats | 1992 |
Low-affinity binding sites for 1,4-dihydropyridines in skeletal muscle transverse tubule membranes revealed by changes in the fluorescence of felodipine.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cations; Cell Membrane; Dihydropyridines; Felodipine; Fluorescent Dyes; Isradipine; Kinetics; Muscles; Rabbits; Spectrometry, Fluorescence | 1992 |
Effects of GTP analogues and activation of endogenous protein kinases on photoaffinity labeling with [3H](+)PN200-110 of crude membranes from rat heart and brain.
Topics: Affinity Labels; Animals; Brain; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Guanosine Triphosphate; Isradipine; Male; Myocardium; Photochemistry; Protein Kinases; Rats; Rats, Inbred Strains; Tritium | 1992 |
Calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self-administration in drug-naive mice.
Topics: Animals; Calcium Channel Blockers; Cocaine; Dihydropyridines; Dopamine; Injections, Intravenous; Isradipine; Mice; Morphine; Nimodipine; Reinforcement, Psychology; Reward; Self Administration | 1992 |
Further evidence for the mechanisms that may mediate nicotine discrimination.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Discrimination Learning; Dopamine; Dose-Response Relationship, Drug; Indoles; Isradipine; Male; Nicotine; Rats; Rats, Inbred Strains; Thiazepines; Tropisetron | 1992 |
Effects of isradipine in Type 1 (insulin-dependent) diabetic patients with albuminuria and normal blood pressure.
Topics: Albuminuria; Blood Pressure; Calcium Channel Blockers; Cholesterol; Diabetes Mellitus, Type 1; Dihydropyridines; Humans; Isradipine; Natriuresis; Reference Values | 1992 |
The diminished extracellular matrix production induced by isradipine, a calcium channel blocker, is completely abolished by cyclooxygenase inhibition.
Topics: Animals; Arteriosclerosis; Aspirin; Calcium Channel Blockers; Collagen; Cyclooxygenase Inhibitors; Dihydropyridines; Drug Interactions; Epoprostenol; Extracellular Matrix; Glycosaminoglycans; Isradipine; Male; Rabbits | 1992 |
[From concept to active substance: genesis of a new drug].
Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Drug Evaluation, Preclinical; Drug Industry; Humans; Isradipine; Pharmaceutical Preparations | 1992 |
Isradipine dynamics and pharmacokinetics in the isolated rabbit heart.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Electrocardiography; Female; Heart; Heart Rate; In Vitro Techniques; Isradipine; Male; Myocardial Contraction; Myocardium; Rabbits | 1992 |
Pharmacokinetics and dialysability of isradipine in chronic haemodialysis patients.
Topics: Administration, Oral; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Isradipine; Male; Renal Dialysis; Time Factors | 1992 |
Kinetics of binding of dihydropyridine calcium channel ligands to skeletal muscle membranes: evidence for low-affinity sites and for the involvement of G proteins.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Isradipine; Kinetics; Ligands; Membrane Proteins; Microsomes; Muscles; Nitrendipine; Oxadiazoles; Rabbits; Receptors, Nicotinic; Stereoisomerism; Thionucleotides | 1991 |
A rapid procedure for the purification of cardiac 1,4-dihydropyridine receptors from porcine heart.
Topics: Affinity Labels; Animals; Azides; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Isradipine; Membranes; Myocardium; Phosphorylation; Photochemistry; Protein Kinases; Receptors, Nicotinic; Sarcolemma; Swine | 1991 |
Sequential changes in muscarinic acetylcholine, adenosine A1 and calcium antagonist binding sites in the gerbil hippocampus following repeated brief ischemia.
Topics: Adenosine; Animals; Autoradiography; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Gerbillinae; Hippocampus; Isradipine; Male; Quinuclidinyl Benzilate; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Purinergic | 1991 |
Dihydropyridine receptors are primarily functional L-type calcium channels in rabbit ventricular myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Heart Ventricles; Isradipine; Myocardium; Rabbits; Receptors, Nicotinic | 1991 |
Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.
Topics: Amino Acid Sequence; Animals; Antibodies; Azides; Binding Sites; Binding Sites, Antibody; Calcium Channel Blockers; Calcium Channels; Chromatography, Affinity; Dihydropyridines; Isradipine; Macromolecular Substances; Molecular Sequence Data; Muscles; Peptide Fragments; Peptides; Receptors, Nicotinic; Tritium; Trypsin | 1991 |
Postnatal maturation of excitation-contraction coupling in rat ventricle in relation to the subcellular localization and surface density of 1,4-dihydropyridine and ryanodine receptors.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Dihydropyridines; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cholinergic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Subcellular Fractions; Ventricular Function | 1991 |
Effects of chronic lithium, amitriptyline, and electroconvulsive shock, on calcium channel binding in a rat brain homogenate.
Topics: Amitriptyline; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diet; Dihydropyridines; Electroshock; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Isradipine; Lithium; Male; Nerve Tissue Proteins; omega-Conotoxins; Peptides, Cyclic; Rats; Rats, Inbred Strains | 1991 |
Regulation of K+ and Ca2+ channels in experimental cardiac failure.
Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Calcium Channels; Coronary Vessels; Dihydropyridines; Glyburide; Heart Failure; Heart Ventricles; Isradipine; Ligation; Male; Organ Size; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1991 |
Neuropsychopharmacological studies of a Ca2+ channel blocker on the modulation of brain Ca2+ mobilization of spontaneously hypertensive rats under mild stress.
Topics: Acoustic Stimulation; Animals; Binding Sites; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diazepam; Dihydropyridines; Hippocampus; Isoindoles; Isradipine; Kinetics; Male; Motor Activity; Nitrendipine; Organ Specificity; Piperazines; Pyrimidines; Rats; Rats, Inbred SHR; Reference Values; Stress, Psychological; Synaptosomes | 1991 |
A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Electrophysiology; Heart; Heart Ventricles; Isradipine; Myocardium; Potassium; Pyrroles; Rats; Ventricular Function | 1991 |
Effects of four diltiazem stereoisomers on binding of d-cis-[3H]diltiazem and (+)-[3H]PN200-110 to rabbit T-tubule calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Isradipine; Kinetics; Muscles; Rabbits; Radioligand Assay; Receptors, Drug; Receptors, Nicotinic; Stereoisomerism; Tritium | 1991 |
Modulation of [3H]dihydropyridine binding by activation of protein kinase C in vascular smooth muscle.
Topics: Aluminum; Animals; Binding Sites; Calcium Channels; Dihydropyridines; Enzyme Activation; Fluorine; Horses; In Vitro Techniques; Isradipine; Membrane Potentials; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Phosphorylation; Portal Vein; Potassium Chloride; Protein Kinase C; Tritium | 1991 |
Pharmacology of Ca2+ channels in smooth muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Isradipine; Membrane Potentials; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Protein Kinase C; Rats | 1991 |
Postischemic alteration of muscarinic acetylcholine, adenosine A1 and calcium antagonist binding sites in selectively vulnerable areas: an autoradiographic study of gerbil brain.
Topics: Adenosine; Animals; Autoradiography; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Gerbillinae; Ischemic Attack, Transient; Isradipine; Male; Organ Specificity; Quinuclidinyl Benzilate; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Purinergic; Time Factors; Tritium | 1991 |
Radiosynthesis of a calcium channel antagonist [11C]PN 200-110 (isrodipine).
Topics: Calcium Channel Blockers; Carbon Radioisotopes; Dihydropyridines; Isotope Labeling; Isradipine | 1991 |
Influence of high sodium intake on urinary calcium excretion and cardiac calcium channels in spontaneously hypertensive rats.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Creatinine; Dihydropyridines; Hypertension; Isradipine; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Sodium, Dietary | 1991 |
Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Guanosine Triphosphate; Isradipine; Neurons; Nitrendipine; Oxadiazoles; Rats; Tumor Cells, Cultured | 1990 |
An endogenous Ca2+ channel agonist, endothelin-1, does not directly activate partially purified dihydropyridine-sensitive Ca2+ channel from cardiac muscle in a reconstituted system.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Endothelins; Heart; Isradipine; Kinetics; Liposomes; Microsomes; Oxadiazoles; Proteolipids; Sarcolemma; Swine; Verapamil | 1990 |
Ca2+ channel inhibition by a new dihydropyridine derivative, S11568, and its enantiomers S12967 and S12968.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Radioisotopes; Cell Line; Dihydropyridines; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Inosine Triphosphate; Isradipine; Male; Muscle, Smooth, Vascular; Myocardium; Oxadiazoles; Rats; Ryanodine; Stereoisomerism | 1990 |
Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Binding Sites; Calcium Channels; Cell Line; Cell Membrane; Dihydropyridines; DNA; Electric Conductivity; Gene Expression; Ion Channel Gating; Isradipine; Kinetics; L Cells; Macromolecular Substances; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic; Transfection | 1991 |
Different sensitivities to dihydropyridines of catecholamine release from cat and ox adrenals.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Catecholamines; Cats; Cattle; Dihydropyridines; In Vitro Techniques; Isradipine; Male; Nitrendipine; Perfusion; Species Specificity | 1990 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
Steady-state currents through voltage-dependent, dihydropyridine-sensitive Ca2+ channels in GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Electric Conductivity; Electrophysiology; Isradipine; Membrane Potentials; Pituitary Neoplasms; Rats | 1991 |
Comprehensive cardiovascular care with a first-line antihypertensive agent. Proceeding of a symposium. Basel, Switzerland, February 13-15, 1991.
Topics: Antihypertensive Agents; Dihydropyridines; Humans; Hypertension; Isradipine | 1991 |
Reversal of left ventricular hypertrophy following treatment of hypertension with isradipine.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Female; Humans; Hypertension; Isradipine; Male; Middle Aged | 1991 |
Serotonin and platelet activation during treatment with isradipine.
Topics: Adult; Aged; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; In Vitro Techniques; Isradipine; Lipoproteins, LDL; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin | 1991 |
Isradipine, a new calcium antagonist: effects on maternal and fetal hemodynamics.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Fetus; Heart Rate; Heart Rate, Fetal; Hemodynamics; Humans; Hypertension; Isradipine; Placenta; Pregnancy; Pregnancy Complications, Cardiovascular; Regional Blood Flow; Uterus | 1991 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Isradipine; Kainic Acid; Nerve Degeneration; Nervous System Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Thermodynamic and kinetic aspects of agonist and antagonist binding to 1,4-dihydropyridine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Male; Membranes; Muscles; Myocardium; Nicotinic Antagonists; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Thermodynamics; Tritium | 1991 |
Modulation of electrical activity and of intracellular calcium oscillations of smooth muscle cells by calcium antagonists, agonists, and vasopressin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Isradipine; Membrane Potentials; Muscle, Smooth, Vascular; Rats; Vasopressins | 1991 |
The beta-adrenergic receptor-regulated 1,4-dihydropyridine calcium channel receptor sites in coronary artery smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channels; Cell Membrane; Cyclic AMP; Dihydropyridines; Dogs; Guanosine Triphosphate; Isoproterenol; Isradipine; Male; Microsomes; Muscle, Smooth, Vascular; Receptors, Adrenergic, beta | 1991 |
Prevention of stroke and brain damage with calcium antagonists in animals.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Damage, Chronic; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Isradipine; Male; Prognosis; Pyridines; Rats; Rats, Inbred SHR | 1991 |
Denervation induced changes in level of Ca-antagonists binding cytosolic protein from white skeletal muscle.
Topics: Animals; Calcium Channel Blockers; Cytosol; Denervation; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Isradipine; Microsomes; Muscles; Oxadiazoles; Rabbits; Receptors, Cholinergic | 1991 |
Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells.
Topics: Animals; Aorta; Basilar Artery; Binding Sites; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Isradipine; Muscle, Smooth, Vascular; Nicardipine; Nitrendipine; Oxadiazoles; Rats; Swine | 1991 |
Electrophysiological effects of oral isradipine (Lomir, Sandoz).
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Electrocardiography; Electrophysiology; Female; Humans; Isradipine; Male; Middle Aged; Sinoatrial Node | 1991 |
Inhibition of binding of [3H]PN200-110 to membranes from rat brain and heart by ascorbate is mediated by lipid peroxidation.
Topics: Animals; Ascorbic Acid; Binding Sites; Brain; Calcium Channel Blockers; Cell Membrane; Culture Techniques; Dihydropyridines; Iron; Isradipine; Lipid Peroxidation; Male; Malondialdehyde; Myocardium; Rats; Rats, Inbred Strains | 1991 |
Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment.
Topics: Adaptation, Psychological; Administration, Inhalation; Animals; Behavior, Animal; Bicuculline; Brain; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ethanol; Isradipine; Male; Mice; Mice, Inbred C57BL; Nimodipine; Nitrendipine; Seizures; Substance Withdrawal Syndrome | 1991 |
Reducing pulse pressure in hypertension may normalize small artery structure.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Captopril; Dihydropyridines; Heart Rate; Hydralazine; Hypertension; Indoles; Isradipine; Male; Metoprolol; Perindopril; Pulse; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regression Analysis | 1991 |
Effects of isradipine on renal function in cyclosporin-treated renal transplanted patients.
Topics: Adult; Aged; Body Water; Calcium Channel Blockers; Cyclosporine; Dihydropyridines; Electrolytes; Female; Hemodynamics; Humans; Isradipine; Kidney; Kidney Transplantation; Lithium; Male; Middle Aged | 1991 |
No clinically significant interaction between ciclosporin and isradipine.
Topics: Calcium Channel Blockers; Cyclosporine; Dihydropyridines; Drug Interactions; Humans; Hypertension, Renal; Isradipine; Kidney Transplantation | 1991 |
Synthesis and biological evaluations of some 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Humans; In Vitro Techniques; Isradipine; Magnetic Resonance Spectroscopy; Microsomes; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidines; Rats; Thiones | 1991 |
Binding sites for 1,4-dihydropyridine Ca(2+)-channel modulators in rat intestinal smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Isradipine; Membrane Potentials; Muscle, Smooth; Rats; Rats, Inbred Strains | 1991 |
Catecholamine release from adrenal gland evoked by lithium. A consequence of [Li]i-[Ca]o counter-transport mechanism?
Topics: Adrenal Glands; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Catecholamines; Cats; Dihydropyridines; Isradipine; Lithium; Sodium | 1991 |
Isradipine, catecholamines, and pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Blood Pressure; Calcium Channel Blockers; Catecholamines; Dihydropyridines; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Pheochromocytoma | 1991 |
Effect of long-term isradipine treatment on the hypertension-dependent changes in coronary arteries in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Vessels; Dihydropyridines; Hypertension; Isradipine; Male; Rats; Rats, Inbred SHR | 1991 |
Electrophysiological properties of rat calcitonin-secreting cells.
Topics: Action Potentials; Animals; Calcitonin; Calcium; Calcium Channel Blockers; Dihydropyridines; Isradipine; Potassium; Rats; Sodium; Tetrodotoxin; Thyroid Gland; Tumor Cells, Cultured | 1991 |
Comparison of the effect of calcium withdrawal from the medium and of blockade of extracellular calcium entry by isradipine on the contractile responses of the isolated rat stomach.
Topics: Animals; Calcium; Carbachol; Dihydropyridines; Female; Isradipine; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stomach | 1991 |
Slow-release isradipine in mild to moderate hypertension: hemodynamic and antihypertensive effects.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Delayed-Action Preparations; Dihydropyridines; Echocardiography, Doppler; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Isradipine; Male; Middle Aged; Monitoring, Physiologic | 1991 |
Reduced calcium sensitivity of dihydropyridine binding to calcium channels in spontaneously hypertensive rats.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Male; Microsomes; Muscles; Myocardium; Oxadiazoles; Rats; Rats, Inbred SHR | 1991 |
Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Isradipine; Male; Muscles; Prostaglandin Endoperoxides, Synthetic; Pyridines; Radioligand Assay; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship; Thromboxane A2; Tritium; Vasoconstriction | 1990 |
Effect of inorganic calcium channel blockers on dihydropyridine binding to cardiac sarcolemma.
Topics: Animals; Cadmium; Calcimycin; Calcium; Calcium Channel Blockers; Dihydropyridines; Dogs; In Vitro Techniques; Isradipine; Lanthanum; Myocardium; Nitrendipine; Ouabain; Oxadiazoles; Quinuclidinyl Benzilate; Sarcolemma | 1990 |
4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Crystallization; Dihydropyridines; Guinea Pigs; Ileum; Isoxazoles; Isradipine; Molecular Conformation; Molecular Structure; Myocardium; Oxadiazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
1,4-Dihydropyridine activators in the tiamdipine series.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardium; Oxadiazoles; Potassium Chloride; Radioligand Assay; Rats; Rats, Inbred WKY; Stereoisomerism | 1990 |
Calcium binding to extracellular sites of skeletal muscle calcium channels regulates dihydropyridine binding.
Topics: Animals; Binding Sites; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cell Membrane; Dihydropyridines; Edetic Acid; Egtazic Acid; Isradipine; Magnesium; Microsomes; Muscles; Myocardium; Oxadiazoles; Rabbits; Sarcolemma | 1990 |
Identification, characterization, and photoaffinity labeling of the dihydropyridine receptor associated with the L-type calcium channel from bovine adrenal medulla.
Topics: Adrenal Medulla; Affinity Labels; Allosteric Regulation; Animals; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cattle; Dihydropyridines; Hot Temperature; Isradipine; Oxadiazoles; Photochemistry; Radioligand Assay; Receptors, Nicotinic; Stereoisomerism; Sulfhydryl Reagents | 1990 |
Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Carps; Cell Membrane; Cerebral Cortex; Dihydropyridines; Diltiazem; Electric Conductivity; Guinea Pigs; Heparin; Isradipine; Molecular Sequence Data; Muscles; Myocardium; Nicotinic Antagonists; Oxadiazoles; Polyelectrolytes; Polymers; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1990 |
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices.
Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; Cyclic AMP; Dihydropyridines; In Vitro Techniques; Inositol Phosphates; Isoproterenol; Isradipine; Norepinephrine; Pyridines; Rats; Receptors, Adrenergic, alpha; Second Messenger Systems; Stereoisomerism | 1990 |
Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons.
Topics: Animals; Antibodies, Monoclonal; Calcium Channels; Dendrites; Dihydropyridines; Hippocampus; Immunoenzyme Techniques; Immunosorbent Techniques; Isradipine; Neurons; omega-Conotoxins; Oxadiazoles; Peptides, Cyclic; Rats; Rats, Inbred Strains; Synaptic Membranes | 1990 |
Action of chlormethiazole in a model of ethanol withdrawal.
Topics: Animals; Calcium Channels; Chlormethiazole; Dihydropyridines; Ethanol; Isradipine; Male; Mice; Motor Activity; Oxadiazoles; Seizures; Substance Withdrawal Syndrome | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Ion Channels; Isradipine; Kinetics; Membrane Potentials; Membranes; Myocardium; Nicotinic Acids; Nimodipine; Nitrendipine; Oxadiazoles; Pyridines; Stereoisomerism; Structure-Activity Relationship | 1987 |
Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential-dependent blockade by Ro 18-3981.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Isradipine; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Potassium; Pyridines | 1987 |
Dihydropyridine chirality at the chromaffin cell calcium channel.
Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cats; Chromaffin System; Dihydropyridines; Female; Ion Channels; Isradipine; Male; Oxadiazoles; Potassium; Pyridines; Stereoisomerism | 1987 |
The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channels; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Verapamil | 1987 |
Monoclonal antibody identifies a 200-kDa subunit of the dihydropyridine-sensitive calcium channel.
Topics: Animals; Antibodies, Monoclonal; Calcium; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Ion Channels; Isradipine; Macromolecular Substances; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits | 1987 |
Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Membrane Proteins; Molecular Weight; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma | 1987 |
Effect of daunorubicin on dihydropyridine-sensitive binding sites in cardiac sarcolemma.
Topics: Animals; Calcium; Cricetinae; Daunorubicin; Dihydropyridines; Female; In Vitro Techniques; Ion Channels; Isradipine; Male; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Sarcolemma | 1987 |
Dihydropyridine-sensitive Ca2+ channel in aneurally cultured human muscles. Relationship between high-affinity binding site and inhibition of calcium uptake.
Topics: Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cells, Cultured; Dihydropyridines; Electrophysiology; Humans; Ion Channels; Isradipine; Muscles; Nitrendipine; Oxadiazoles; Potassium | 1988 |
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Rabbits; Rats; Time Factors | 1987 |
Binding of dihydropyridine calcium antagonists to membranes from human skeletal muscle.
Topics: Animals; Azides; Binding Sites; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Humans; In Vitro Techniques; Ion Channels; Isradipine; Muscle Proteins; Muscles; Oxadiazoles; Rabbits | 1988 |
Comparative binding of two closely related dihydropyridines (isradipine and darodipine) to serum proteins and erythrocytes.
Topics: Binding, Competitive; Blood Proteins; Calcium Channel Blockers; Dihydropyridines; Erythrocytes; gamma-Globulins; Humans; Isradipine; Lipoproteins; Nifedipine; Pyridines | 1988 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
Multiple calcium channels in synaptosomes: voltage dependence of 1,4-dihydropyridine binding and effects on function.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Male; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Verapamil | 1988 |
Central modulation of baroreceptor reflex response to phenylephrine by dihydropyridines in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine Derivatives; Blood Pressure; Brain; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Muscarine; Oxadiazoles; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reflex | 1988 |
Secretion from adrenaline- and noradrenaline-storing adrenomedullary cells is regulated by a common dihydropyridine-sensitive calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium; Calcium Channel Blockers; Cats; Dihydropyridines; Dimethylphenylpiperazinium Iodide; Epinephrine; In Vitro Techniques; Ion Channels; Isradipine; Norepinephrine; Oxadiazoles; Potassium; Reference Values | 1988 |
Voltage-dependent calcium channels in skeletal muscle transverse tubules. Measurements of calcium efflux in membrane vesicles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzothiazoles; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Carbocyanines; Cell Membrane; Dihydropyridines; Edetic Acid; Fluorescent Dyes; Isradipine; Lanthanum; Membrane Potentials; Muscles; Nitrendipine; Oxadiazoles; Potassium; Rabbits; Verapamil | 1989 |
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydropyridines; Indicators and Reagents; Isradipine; Male; Myocardium; Oxadiazoles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Nicotinic; Time Factors; Verapamil | 1989 |
Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Gene Expression; Isradipine; Kinetics; Oxadiazoles; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1989 |
(+)-PN200-110 and ouabain binding sites in purified bovine adrenomedullary plasma membranes and chromaffin cells.
Topics: Adrenal Medulla; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cattle; Cell Membrane; Chromaffin System; Dihydropyridines; Isradipine; Kinetics; Ouabain; Oxadiazoles; Stereoisomerism | 1989 |
Cortical dihydropyridine binding sites are unaltered in human alcoholic brain.
Topics: Alcoholism; Cerebral Cortex; Dihydropyridines; Humans; Isradipine; Male; Middle Aged; Nitrendipine; Oxadiazoles | 1989 |
Improved radioreceptor assay for the determination of plasma levels of dihydropyridine calcium channel blockers in humans.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Mass Spectrometry; Nicardipine; Nitrendipine; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains | 1989 |
Relaxation of potassium chloride-induced contractions by amlodipine and its interaction with the 1,4-dihydropyridine-binding site in pig coronary artery.
Topics: Amlodipine; Animals; Binding Sites; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Isradipine; Nifedipine; Oxadiazoles; Potassium Chloride; Sarcolemma; Stereoisomerism; Swine; Vasoconstriction; Vasodilation | 1989 |
Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydro-pyridine-3,5-di- carboxylic acid.
Topics: Animals; Calcium; Cats; Cerebral Cortex; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Esters; Guinea Pigs; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Papillary Muscles; Potassium; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Inhibition of dihydropyridine-sensitive calcium channels by the plant alkaloid ryanodine.
Topics: Alkaloids; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Lipid Bilayers; Microsomes; Muscles; Oxadiazoles; Rabbits; Receptors, Nicotinic; Ryanodine | 1989 |
Voltage-dependent binding of 1,4-dihydropyridine Ca2+ channel antagonists and activators in cultured neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Diltiazem; Gallopamil; Heart Ventricles; In Vitro Techniques; Isradipine; Membrane Potentials; Oxadiazoles; Potassium; Rats | 1989 |
Ca2+ channels in chick neural retina cells characterized by 1,4-dihydropyridine antagonists and activators.
Topics: Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Chick Embryo; Dihydropyridines; Isradipine; Neuroglia; Neuromuscular Depolarizing Agents; Oxadiazoles; Potassium; Retina; Stereoisomerism | 1989 |
(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Isradipine; Liver; Male; Muscles; Myocardium; Pyridines; Rats; Receptors, Adrenergic, alpha; Stereoisomerism | 1989 |
Is Ca2+ antagonists binding protein from cytosolic fraction the precursor of alpha 1-subunit of Ca2+ channel?
Topics: Affinity Labels; Animals; Antibodies; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cytoplasm; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Oxadiazoles; Protein Precursors; Rabbits; Radioligand Assay; Receptors, Nicotinic; Ultraviolet Rays; Verapamil | 1989 |
Pharmacological properties of voltage-dependent calcium channels in functional microvessels isolated from rat brain.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; In Vitro Techniques; Isradipine; Kinetics; Membrane Potentials; Microcirculation; Muscle, Smooth, Vascular; Nimodipine; Oxadiazoles; Potassium Chloride; Rats | 1989 |
[3H]PN200-110 and [3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes.
Topics: Alkaloids; Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Chlorides; Dihydropyridines; Electrophoresis; Isradipine; Lipid Bilayers; Membrane Proteins; Membranes; Muscles; Oxadiazoles; Potassium Channels; Rabbits; Ryanodine; Sarcoplasmic Reticulum; Tritium | 1989 |
[3H]HOE166 defines a novel calcium antagonist drug receptor--distinct from the 1,4 dihydropyridine binding domain.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drosophila; Guinea Pigs; In Vitro Techniques; Isradipine; Kinetics; Membranes; Muscles; Oxadiazoles; Piperidines; Proteins; Receptors, Nicotinic; Thiazines | 1989 |
Control of expression of the 1,4-dihydropyridine receptor in BC3H1 cells.
Topics: Animals; Binding, Competitive; Calcium Channels; Cell Differentiation; Cell Line; Dihydropyridines; Isradipine; Mice; Muscles; Oxadiazoles; Peptides; Receptors, Nicotinic; Transforming Growth Factors | 1988 |
Developmental changes of the distribution of binding sites for organic Ca2+-channel blockers in cat visual cortex.
Topics: Aging; Animals; Autoradiography; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cats; Dihydropyridines; Image Processing, Computer-Assisted; Isradipine; Oxadiazoles; Receptors, Nicotinic; Visual Cortex | 1988 |
Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Potentials; Isradipine; Mice; Muscle Contraction; Oxadiazoles; Piperidines; Thiazines; Verapamil | 1988 |
Characterization of binding sites for two classes of calcium channel antagonists in human forebrain.
Topics: Aniline Compounds; Autoradiography; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Humans; In Vitro Techniques; Isradipine; Kinetics; Membranes; Oxadiazoles; Pyridines | 1985 |
Characterization of dihydropyridine binding sites in the rat brain: hypertension and age-dependent modulation of [3H](+)-PN 200-110 binding.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Hypertension; Isradipine; Male; Oxadiazoles; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Tritium | 1987 |
A novel high affinity class of Ca2+ channel blockers.
Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil | 1988 |
Effect of divalent cation chelation on dihydropyridine binding in isolated cardiac sarcolemma vesicles.
Topics: Animals; Calcimycin; Calcium; Cations, Divalent; Dihydropyridines; Dogs; Edetic Acid; Hydrogen-Ion Concentration; Isradipine; Magnesium; Myocardium; Nitrendipine; Ouabain; Oxadiazoles; Phosphates; Sarcolemma | 1988 |
The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition.
Topics: Animals; Anura; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chickens; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Isradipine; Microsomes; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Solubility | 1985 |
(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.
Topics: Animals; Brain Chemistry; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Female; Isradipine; Kinetics; Male; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Temperature; Tritium; Verapamil | 1986 |
Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Dihydropyridines; Isradipine; Molecular Weight; Muscles; Oxadiazoles; Photochemistry; Pyridines; Rabbits; Receptors, Nicotinic | 1987 |
Short-term regulation of neuronal calcium channels by depolarization.
Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Down-Regulation; Homeostasis; Ion Channel Gating; Isradipine; Membrane Potentials; Membrane Proteins; Models, Biological; N-Methylscopolamine; Neurons; Potassium; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Up-Regulation | 1995 |
Glucocorticoid actions on synaptic plasma membranes: modulation of dihydropyridine-sensitive calcium channels.
Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cerebral Cortex; Cyclic AMP; Dihydropyridines; Glucocorticoids; Isradipine; Kinetics; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Steroids; Synapses; Synaptosomes | 1995 |
Biochemical characterization of ethanol actions on dihydropyridine-sensitive calcium channels in brain synaptosomes.
Topics: Adenosine Triphosphate; Alcoholism; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Cyclic AMP; Dihydropyridines; Ethanol; Isradipine; Magnesium; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Synaptosomes; Tritium | 1995 |
PCA 50941, a novel Ca2+ channel agonist.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Calcium Channel Agonists; Cardiovascular System; Dihydropyridines; Heart Atria; In Vitro Techniques; Isradipine; Mesenteric Arteries; Muscles; Nitrendipine; Rabbits; Rats; Rats, Sprague-Dawley; Swine; Thiazoles; Vasoconstriction | 1993 |
Interactions between Ca2+, PCA50941 and Bay K 8644 in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium; Calcium Channel Agonists; Calcium Channels; Catecholamines; Cattle; Cell Membrane; Cytosol; Dihydropyridines; Fura-2; In Vitro Techniques; Isradipine; Patch-Clamp Techniques; Potassium; Thiazoles | 1994 |
Single calcium channel behavior in native skeletal muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium Compounds; Cadmium; Cadmium Chloride; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Chlorides; Dihydropyridines; Electrophysiology; Isradipine; Lanthanum; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Patch-Clamp Techniques | 1995 |
Synthesis, structure, and pharmacological evaluation of the stereoisomers of furnidipine.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Dihydropyridines; Drug Evaluation, Preclinical; Guinea Pigs; Heart; In Vitro Techniques; Isradipine; Kinetics; Molecular Conformation; Molecular Structure; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tritium | 1995 |
Effects of tetrandrine on left ventricle hypertrophy in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Alkaloids; Animals; Antihypertensive Agents; Benzylisoquinolines; Binding, Competitive; Blood Pressure; Body Weight; Calcium; Desoxycorticosterone; Dihydropyridines; Disease Models, Animal; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Isradipine; Male; Mitochondria, Heart; Organ Size; Radioligand Assay; Random Allocation; Rats; Rats, Sprague-Dawley | 1995 |
Residual inhibition in density of [3H]isradipine binding sites in rat brain membrane pretreated with amlodipine.
Topics: Amlodipine; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Nifedipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Wistar | 1995 |
Estradiol modulation of GNRH-stimulated LH release in rat anterior pituitary cells: involvement of dihydropyridine-sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Estradiol; Female; Gallopamil; Gonadotropin-Releasing Hormone; Isradipine; Luteinizing Hormone; Ovariectomy; Pituitary Gland, Anterior; Protein Kinase C; Radioimmunoassay; Rats; Rats, Wistar | 1993 |
Effects of oxodipine and elgodipine on (+)-[3H]-isradipine binding to cardiac and vascular membranes: cardiovascular selectivity.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Dihydropyridines; Horses; In Vitro Techniques; Isradipine; Myocardium; Portal Vein; Rats | 1994 |
Effect of ethanol exposure on voltage-dependent calcium channels in in vitro cellular models.
Topics: Animals; Binding Sites; Calcium Channels; Cell Differentiation; Cell Line; Dihydropyridines; Ethanol; Hybrid Cells; In Vitro Techniques; Isradipine; Neurons; omega-Conotoxin GVIA; Peptides | 1993 |
Inhibition of cardiac L-type calcium channels by quaternary amlodipine: implications for pharmacokinetics and access to dihydropyridine binding site.
Topics: Amlodipine; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Guinea Pigs; Heart Ventricles; Humans; Isradipine; Kinetics; Membrane Potentials; Muscle, Skeletal; Myocardium; Rabbits | 1995 |
Mechanisms of the potent and long-lasting antihypertensive action of the new calcium channel blocker pranidipine. Evidence for strong affinity to the calcium channels or membranes.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry, Physical; Dihydropyridines; In Vitro Techniques; Isradipine; Male; Membranes; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Wistar; Swine | 1995 |
Modulation of dihydropyridine receptors in vascular smooth muscle cells by membrane potential and cell proliferation.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Cell Division; Cell Line; Dihydropyridines; Isradipine; Membrane Potentials; Muscle Proteins; Muscle, Smooth, Vascular; Rats | 1994 |
Inhibition of L-type Ca2+ channels in portal vein myocytes by the enantiomers of oxodipine.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Computer Simulation; Dihydropyridines; Dose-Response Relationship, Drug; Electrophysiology; Isradipine; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Portal Vein; Radioligand Assay; Rats; Stereoisomerism | 1994 |
Autocrine production of endothelin-1 participates in the glucocorticoid-induced Ca2+ influx into vascular smooth muscle cells.
Topics: Animals; Aorta; Azepines; Biological Transport; Calcium; Carbon Radioisotopes; Cell Line; Dexamethasone; Dihydropyridines; Endothelin Receptor Antagonists; Endothelins; Indoles; Isradipine; Kinetics; Muscle, Smooth, Vascular; Rats; Receptors, Endothelin | 1995 |
Cytosolic Ca2+ of excitable pituitary cells at resting potentials is controlled by steady state Ca2+ currents sensitive to dihydropyridines.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Cytosol; Dihydropyridines; Isradipine; Membrane Potentials; Pituitary Gland | 1994 |
In vitro antioxidant activity of calcium antagonists against LDL oxidation compared with alpha-tocopherol.
Topics: Adult; Amlodipine; Antioxidants; Calcium Channel Blockers; Copper; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Humans; Isradipine; Lipoproteins, LDL; Oxidation-Reduction; Reference Values; Thiobarbituric Acid Reactive Substances; Verapamil; Vitamin E | 1994 |
Canine myocardial dihydropyridine binding sites: a positron emission tomographic study with the calcium channel inhibitor 11C-S11568.
Topics: Animals; Binding Sites; Blood Pressure; Calcium Channel Blockers; Carbon Radioisotopes; Coronary Vessels; Dihydropyridines; Dogs; Female; Heart; Heart Rate; Isradipine; Myocardium; Tomography, Emission-Computed | 1994 |
Electrophysiological and radioligand binding studies of elgodipine and derivatives in portal vein myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Dihydropyridines; In Vitro Techniques; Isradipine; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Radioligand Assay; Rats; Structure-Activity Relationship | 1994 |
Modulation of L-type Ca2+ channels in clonal rat pituitary cells by membrane depolarization.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Down-Regulation; Isradipine; Kinetics; Membrane Potentials; Pituitary Gland, Anterior; Rats | 1994 |
Decreased density of binding sites for the Ca2+ channel antagonist [3H]isradipine after denervation of rat vas deferens.
Topics: Animals; Binding Sites; Calcium Channels; Denervation; Dihydropyridines; Isradipine; Male; Muscle Contraction; Potassium Chloride; Rats; Rats, Wistar; Vas Deferens | 1994 |
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex; Dihydropyridines; Hippocampus; Isradipine; Ligands; Membrane Proteins; Nitrendipine; Protein Binding; Swine; Synaptosomes; Time Factors | 1994 |
Ryanodine and dihydropyridine binding patterns and ryanodine receptor mRNA levels in myopathic hamster heart.
Topics: Animals; Calcium; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; Doxorubicin; Electrophysiology; Isradipine; Membrane Proteins; Muscle Proteins; Myocardium; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel | 1994 |
In-vivo binding of (+)-[3H]PN 200-110 to peripheral tissues and brain of spontaneously hypertensive rats: effect of lacidipine.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding Sites; Brain; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Heart; Ileum; Injections, Intravenous; Isradipine; Male; Myocardium; Rats; Rats, Inbred SHR; Tritium; Urinary Bladder | 1993 |
Neuropharmacological characterization of voltage-sensitive calcium channels: possible existence of neomycin-sensitive, omega-conotoxin GVIA- and dihydropyridines-resistant calcium channels in the rat brain.
Topics: Animals; Binding Sites; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Chickens; Corpus Striatum; Dihydropyridines; Dopamine; In Vitro Techniques; Isradipine; Kainic Acid; Male; Neomycin; omega-Conotoxin GVIA; Oxidopamine; Peptides; Rats; Rats, Wistar; Synaptosomes | 1993 |
Volatile anesthetics inhibit dihydropyridine binding to malignant hyperthermia-susceptible and normal pig skeletal muscle membranes.
Topics: Anesthetics; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Drug Interactions; Halothane; Isradipine; Malignant Hyperthermia; Membranes; Muscle Proteins; Muscles; Swine; Tritium | 1994 |
Pharmacological studies on a new Dihydrothienopyridine calcium antagonist. 2nd communication: effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate on the 1,4-dihydropyridine binding sites in the bra
Topics: Animals; Binding, Competitive; Brain Chemistry; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Arteries; Dihydropyridines; Female; In Vitro Techniques; Isradipine; Macaca fascicularis; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular | 1993 |
Differential effects of non-peptidic tachykinin receptor antagonists on Ca2+ channels.
Topics: Animals; Calcium Channels; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Rats; Receptors, Tachykinin; Verapamil | 1994 |
Calcium channel blocking properties of SM-6586 in rat heart and brain as assessed by radioligand binding assay.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Brain; Calcium Channel Blockers; Dihydropyridines; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Oxadiazoles; Potassium; Radioligand Assay; Rats; Rats, Wistar; Tritium; Vasoconstriction | 1993 |
Activation of gastric mucosal calcium channels by epidermal growth factor.
Topics: Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Chromatography, Affinity; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Gastric Mucosa; In Vitro Techniques; Isradipine; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Major role of dihydropyridine-sensitive Ca2+ channels in Ca(2+)-induced calcitonin secretion.
Topics: Animals; Calcitonin; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cells, Cultured; Dihydropyridines; Isradipine; Membrane Potentials; omega-Conotoxins; Peptides, Cyclic; Rats; Tetrodotoxin; Thyroid Gland; Time Factors | 1993 |
Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases.
Topics: Aged; Alzheimer Disease; Autopsy; Binding Sites; Brain; Calcium; Calcium Channels; Dihydropyridines; Female; Humans; Huntington Disease; Isradipine; Male; Middle Aged; Organ Specificity; Parkinson Disease; Reference Values; Verapamil | 1993 |
Effects of modulators of cytosolic Ca2+ on phytohemagglutin-dependent Ca2+ response and interleukin-2 production in Jurkat cells.
Topics: Affinity Labels; Azides; Binding Sites; Calcium; Calcium Channel Blockers; Cytosol; Dihydropyridines; Gallic Acid; Glycoproteins; Humans; Interleukin-2; Isradipine; Kinetics; Nifedipine; Phytohemagglutinins; Ryanodine; T-Lymphocytes; Tumor Cells, Cultured | 1993 |
Radioligand and functional estimates of the interaction of the 1,4-dihydropyridines, isradipine and lacidipine, with calcium channels in smooth muscle.
Topics: Animals; Arginine; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Electrophysiology; In Vitro Techniques; Isradipine; Kinetics; Male; Microsomes; Mitochondria, Muscle; Muscle, Smooth; Nitroarginine; Potassium Chloride; Radioligand Assay; Rats; Rats, Wistar | 1993 |
Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carps; Dihydropyridines; Ion Channel Gating; Isradipine; Molecular Sequence Data; omega-Agatoxin IVA; omega-Conotoxins; Peptide Fragments; Peptides; Protein Structure, Tertiary; Pyrroles; Rabbits; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spider Venoms | 1996 |
Calcium currents in postinfarction rat cardiac myocytes.
Topics: Animals; Calcium; Dihydropyridines; Electric Conductivity; Heart; Isoproterenol; Isradipine; Male; Myocardial Infarction; Myocardium; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Sarcolemma | 1995 |
Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells.
Topics: Adrenergic beta-Antagonists; Amlodipine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Diuretics; Felodipine; Fibroblasts; Furosemide; Gene Expression Regulation; Humans; Interleukin-6; Interleukin-8; Isradipine; Lung; Muscle Proteins; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Propranolol; Transcription, Genetic | 1995 |
Molecular determinants of high affinity dihydropyridine binding in L-type calcium channels.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cloning, Molecular; Dihydropyridines; Isradipine; Kinetics; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Rabbits; Radioligand Assay; Recombinant Proteins; Structure-Activity Relationship; Tritium | 1996 |
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Dihydropyridines; Enzyme Inhibitors; Guinea Pigs; Humans; Isradipine; Molecular Structure; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P1; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 1996 |
Interaction of lacidipine with its receptor binding site supports a slow onset and long duration of action.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Drug Administration Schedule; Guinea Pigs; Isradipine; Male; Myocardium; Time Factors | 1996 |
Nitric oxide (EDRF) enhances the vasorelaxing effect of dihydropyridine calcium antagonists in isolated human middle cerebral arteries.
Topics: Adult; Arginine; Calcium Channel Blockers; Cerebral Arteries; Cyclooxygenase Inhibitors; Dihydropyridines; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; In Vitro Techniques; Indomethacin; Isradipine; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Vasodilator Agents | 1996 |
Enantiomer separation of dihydropyridine calcium antagonists with cyclodextrins as chiral selectors: structural correlation.
Topics: Amlodipine; Buffers; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cyclodextrins; Dihydropyridines; Electrolytes; Electrophoresis, Capillary; Isradipine; Microspheres; Molecular Conformation; Nimodipine; Nisoldipine; Nitrendipine; Sodium Dodecyl Sulfate; Solvents; Stereoisomerism; Surface-Active Agents | 1996 |
The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Free Radicals; Fumarates; Guinea Pigs; Heart Ventricles; Isradipine; Myocardium; Patch-Clamp Techniques; Ventricular Function | 1996 |
Dihydropyridine and ryanodine binding in ventricles from rat, trout, dogfish and hagfish.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Dogfish; Female; Hagfishes; Heart Ventricles; Isradipine; Muscle Proteins; Myocardial Contraction; Myocardium; Oncorhynchus mykiss; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Tritium | 1996 |
Meiosis reinitiation in Ruditapes philippinarum (Mollusca): involvement of L-calcium channels in the release of metaphase I block.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bivalvia; Boron Compounds; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Electrophysiology; Female; Fertilization in Vitro; Fluorescence; Isradipine; Male; Meiosis; Metaphase; Oocytes; Potassium Chloride; Prophase; Serotonin | 1996 |
Subunit composition is a major determinant in high affinity binding of a Ca2+ channel blocker.
Topics: Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cations, Divalent; COS Cells; Dihydropyridines; Isradipine; Kinetics; Macromolecular Substances; Muscle, Skeletal; Stimulation, Chemical; Transfection | 1996 |
Meiosis reinitiation of mussel oocytes involves L-type voltage-gated calcium channel.
Topics: Animals; Binding Sites; Bivalvia; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Ion Channel Gating; Isradipine; Meiosis; Oocytes; Potassium Chloride; Tritium | 1997 |
Binding and distribution of three prototype calcium channel blockers in perfused rat liver.
Topics: Animals; Azides; Calcium Channel Blockers; Calcium Channels; Carbon Radioisotopes; Dihydropyridines; Inulin; Isradipine; Liver; Models, Biological; Perfusion; Rats; Rats, Sprague-Dawley; Time Factors; Tritium; Urea; Verapamil | 1997 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Carbamazepine; Dantrolene; Dihydropyridines; Disease Models, Animal; Drug Interactions; Electroshock; Epilepsy; Female; Isradipine; Lethal Dose 50; Mice; Motor Activity; Phenobarbital; Phenytoin; Random Allocation; Seizures; Valproic Acid | 1997 |
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluorescent Dyes; Isomerism; Isradipine; Kinetics; Nicotinic Acids; Nifedipine; Nitrendipine; Oxadiazoles; Rabbits | 1997 |
Global ischemia increases the density of voltage-dependent calcium channels in porcine cardiac sarcolemma.
Topics: 5'-Nucleotidase; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Heart Ventricles; In Vitro Techniques; Isradipine; Myocardial Ischemia; Myocardium; Sarcolemma; Swine | 1997 |
Synthesis of two optically active calcium channel antagonists labelled with carbon-11 for in vivo cardiac PET imaging.
Topics: Amlodipine; Animals; Binding, Competitive; Calcium Channel Blockers; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dihydropyridines; Dogs; Heart; Heart Diseases; Isotope Labeling; Isradipine; Magnetic Resonance Spectroscopy; Muscle, Smooth, Vascular; Myocardium; Reproducibility of Results; Stereoisomerism; Tomography, Emission-Computed | 1997 |
Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Electrophysiology; Isradipine; Ligands; Male; Mice; Mice, Knockout; Myocardium; Patch-Clamp Techniques; Receptors, Estrogen; Transcription Factors | 1997 |
Dissection of functional domains of the voltage-dependent Ca2+ channel alpha2delta subunit.
Topics: Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Humans; Isradipine; Kinetics; Protein Biosynthesis; Protein Conformation; Transcription, Genetic; Transfection | 1997 |
Direct antiatherogenic activity of isradipine and lacidipine on neointimal lesions induced by perivascular manipulation in rabbits.
Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Hypercholesterolemia; Isradipine; Male; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Rabbits | 1997 |
AE0047-mediated calcium channel blocking in vascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Calcium Radioisotopes; Cattle; Chemical Phenomena; Chemistry, Physical; Dihydropyridines; Dogs; Drug Carriers; In Vitro Techniques; Isradipine; Liposomes; Male; Membranes; Microsomes; Muscle Contraction; Muscle, Smooth, Vascular; Radioligand Assay; Rats; Rats, Wistar; Synaptic Membranes | 1997 |
Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Humans; Isradipine; Molecular Sequence Data; Mutagenesis, Site-Directed | 1997 |
Isradipine and lacidipine: effects in vivo and in vitro on Trypanosoma cruzi epimastigotes.
Topics: Animals; Calcium Channel Blockers; Cattle; Dihydropyridines; Diltiazem; Isradipine; Oxygen Consumption; Trypanocidal Agents; Trypanosoma cruzi; Verapamil | 1998 |
Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Halothane; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Wistar; Sarcolemma; Verapamil | 1998 |
Growth hormone regulates the distribution of L-type calcium channels in rat adipocyte membranes.
Topics: Adipocytes; Adipose Tissue; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cells, Cultured; Cytosol; Dihydropyridines; Epididymis; Growth Hormone; Isradipine; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains | 1998 |
Molecular mechanism of diltiazem interaction with L-type Ca2+ channels.
Topics: Alanine; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; DNA Mutational Analysis; Electric Conductivity; Electrophysiology; Ion Channel Gating; Isradipine; Muscle, Skeletal; Mutagenesis | 1998 |
Distinctions in the molecular determinants of charged and neutral dihydropyridine block of L-type calcium channels.
Topics: Amino Acid Sequence; Amino Acid Substitution; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Dihydropyridines; Humans; Isradipine; Kinetics; Membrane Potentials; Models, Molecular; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Structure, Secondary; Recombinant Fusion Proteins; Recombinant Proteins; Threonine; Transfection; Tyrosine; Verapamil | 1999 |
Reconstruction of the dihydropyridine site in a non-L-type calcium channel: the role of the IS6 segment.
Topics: Animals; Calcium Channels; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Electrophysiology; Inhibitory Concentration 50; Isradipine; Mutagenesis; Recombinant Fusion Proteins | 1999 |
Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dihydropyridines; Discrimination Learning; Ethanol; Feeding Behavior; Isradipine; Male; Nifedipine; Rats; Taste | 1999 |
In vivo receptor occupancy and plasma concentration of pranidipine, a potent and long-acting dihydropyridine calcium antagonist.
Topics: Algorithms; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Isradipine; Male; Myocardium; Nifedipine; Rats; Rats, Inbred SHR | 1999 |
Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Heart Atria; Heart Block; Heart Rate; Isradipine; Male; Myocardial Contraction; Nifedipine; Pyridines; Rats; Rats, Sprague-Dawley; Systole; Ventricular Function, Left; Ventricular Pressure | 1999 |
State- and isoform-dependent interaction of isradipine with the alpha1C L-type calcium channel.
Topics: Alternative Splicing; Barium; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Ion Transport; Isradipine; Membrane Potentials; Muscle, Smooth; Mutagenesis, Site-Directed; Myocardium; Patch-Clamp Techniques; Protein Isoforms; Transfection | 2000 |
Pharmacodynamic interaction between mibefradil and other calcium channel blockers.
Topics: Amlodipine; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Cell Membrane; Dihydropyridines; Drug Interactions; Ethosuximide; Female; Gallopamil; Humans; In Vitro Techniques; Isradipine; Male; Mibefradil; Myocardial Contraction; Perfusion; Radioligand Assay; Rats; Rats, Wistar; Ventricular Pressure | 2000 |
In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain.
Topics: Aging; Animals; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Mice; Myocardium | 2000 |
Gestational changes in uterine L-type calcium channel function and expression in guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Female; Guinea Pigs; Isradipine; Molecular Sequence Data; Pregnancy; Pregnancy, Animal; Rabbits; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Uterine Contraction; Uterus | 2000 |
Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Extraembryonic Membranes; Female; Guinea Pigs; Humans; Isradipine; Obstetric Labor, Premature; Organ Specificity; Placenta; Pregnancy; Random Allocation; Rats; Rats, Wistar; Uterine Contraction | 2001 |
Mechanism of dihydropyridine interaction with critical binding residues of L-type Ca2+ channel alpha 1 subunits.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Female; Isoleucine; Isradipine; Kinetics; Methionine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Phenylalanine; Protein Structure, Secondary; Protein Subunits; Recombinant Proteins; Valine; Xenopus laevis | 2001 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
Topics: Androstadienes; Animals; Barium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Female; Gene Expression; GTP-Binding Proteins; Ion Channel Gating; Isradipine; Myocardium; Neurons; Oocytes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Wortmannin; Xenopus laevis | 2001 |
In vivo measurement of 1,4-dihydropyridine receptors in mesenteric arteries of spontaneously hypertensive rats and effect of nifedipine and cilnidipine.
Topics: Animals; Area Under Curve; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Injections, Intravenous; Isradipine; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred SHR; Tissue Distribution | 2002 |
Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cloning, Molecular; Dihydropyridines; Humans; Ion Channel Gating; Isradipine; Kidney; Molecular Sequence Data; Patch-Clamp Techniques; Protein Subunits; Sequence Homology, Amino Acid; Transfection | 2003 |
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.
Topics: Alanine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Isradipine; Phenylalanine; Point Mutation; Protein Subunits; Pyrroles; Rats; Repetitive Sequences, Nucleic Acid; Serine | 2003 |
Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Dihydropyridines; Female; Hypothyroidism; In Vitro Techniques; Isradipine; Mice; Mice, Inbred C57BL; Muscle, Smooth; Thyroid Hormones; Uterine Contraction; Uterus | 2003 |
Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diterpenes; Furans; Ileum; In Vitro Techniques; Isradipine; Male; Membranes; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Radioligand Assay; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 2004 |
Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Cell Line; Collagen Type I; Culture Media; Dihydropyridines; Fibroblast Growth Factors; Fibroblasts; Gingiva; Humans; Isradipine | 2004 |
Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels.
Topics: Animals; Brain; Calcium; Calcium Channels; Calcium Channels, L-Type; Carrier Proteins; Cell Membrane; Dihydropyridines; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Gallopamil; Homozygote; In Situ Hybridization; Isradipine; Kinetics; Mice; Mice, Transgenic; Microsomes; Models, Biological; Mutation; Oocytes; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; RNA, Complementary; Steroid Isomerases; Tyrosine; Verapamil; Xenopus laevis | 2004 |
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Disease Models, Animal; Isradipine; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinsonian Disorders | 2011 |
Ca
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Heart Rate; Isradipine; Mice, Inbred C57BL; Mice, Knockout; Nifedipine; Patch-Clamp Techniques; Sinoatrial Node | 2017 |