isoxazoles has been researched along with zonisamide in 612 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (3.76) | 18.7374 |
| 1990's | 104 (16.99) | 18.2507 |
| 2000's | 272 (44.44) | 29.6817 |
| 2010's | 210 (34.31) | 24.3611 |
| 2020's | 3 (0.49) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuchi, H; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K; Tanaka, N | 2 |
| Kawakami, K; Miyamoto, K; Nishimura, S; Seino, M; Suzuki, S; Watanabe, Y; Yagi, K | 1 |
| Karasawa, T; Mimaki, T; Suzuki, Y; Tagawa, T; Yabuuchi, H | 2 |
| Kanakubo, Y; Kitada, M; Komiya, M; Nakasa, H; Ohmori, S; Rikihisa, T | 1 |
| Fukushima, Y; Hirano, T; Ishida, M; Kaneko, S; Kondo, T; Okada, M; Otani, K | 1 |
| Iwakawa, S; Nakamura, H; Nakayama, S; Nishiguchi, K; Ohnishi, N; Okumura, K; Takada, S; Yagi, J; Yokoyama, T | 1 |
| Seino, M; Yagi, K | 1 |
| Taira, T | 1 |
| Fukuchi, H; Harada, Y; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K; Tanaka, N | 1 |
| Fujita, T; Takano, K; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Robicheau, JT; Stiff, DD; Zemaitis, MA | 1 |
| Hara, M; Hashimoto, R; Hirai, K; Kimiya, S; Kumagai, N; Seki, T; Suzuki, N; Takuma, Y; Yamada, T; Yamawaki, H | 1 |
| Fujikawa, Y; Fujiwara, T; Kubota, H; Matsuda, K; Seino, M; Yagi, K | 1 |
| Ito, T; Miyazaki, H; Seino, M | 1 |
| Berry, DJ | 1 |
| Ishii, H; Kalbe, K; Kurooka, S; Naruto, S; Nishimura, S; Sunahara, N | 1 |
| Charles, CL; Stoesz, L; Tollefson, G | 1 |
| Fujimoto, Y; Ikoma, R; Shimizu, A; Shimizu, T | 1 |
| Hasegawa, H; Wada, Y; Yamaguchi, N | 1 |
| Hasegawa, H; Okuda, H; Wada, Y; Yamaguchi, N | 1 |
| Schauf, CL | 1 |
| Duncan, JS; Hart, YM; Sander, JW; Shorvon, SD | 1 |
| Fujii, T; Hashimoto, M; Matsumoto, K; Miyazaki, H | 1 |
| Itoh, N; Mimaki, T; Suzuki, Y; Tagawa, T; Tanaka, J; Yabuuchi, H | 1 |
| Gumnit, RJ; Henry, TR; Jacobs, M; Leppik, IE | 1 |
| Kawasaki, T; Shimizu, A; Tanaka, M; Yamada, Y; Yamamoto, J | 1 |
| Barsoum, NJ; DiFonzo, CJ; Macallum, GE; Smith, GS; Walker, RM | 1 |
| Lisgarten, JN; Palmer, RA | 1 |
| Lee, MS; Yost, RA | 1 |
| Furukawa, K; Hori, M; Ito, T; Kadokawa, T; Karasawa, T; Matsuno, Y; Noda, Y; Ochi, Y; Oka, M | 1 |
| Fujitani, B; Ito, T; Kadokawa, T; Matsuno, Y; Nakamura, N; Nakatsuji, K | 1 |
| Hammond, EJ; McLean, JR; Perchalski, RJ; Wilder, BJ | 1 |
| Juergens, U | 1 |
| Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y | 1 |
| Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ | 1 |
| Cornford, EM; Landon, KP | 1 |
| Fujii, T; Hashimoto, M; Kagemoto, A; Maeda, T; Matsumoto, K; Miyazaki, H | 1 |
| Berent, S; Donofrio, PD; Sackellares, JC; Sakmar, E; Wagner, JG | 1 |
| Kakegawa, N; Seino, M | 1 |
| Ishida, S; Ito, T; Kakegawa, N; Miyazaki, H; Seino, M; Sekine, Y; Shimizu, M; Wada, T; Yagi, K; Yamaguchi, T | 1 |
| Hori, M; Ito, T; Masuda, Y; Shimizu, M; Yoshida, K | 1 |
| Kamei, C; Masuda, Y; Oka, M; Shimizu, M; Yoshida, K | 1 |
| Hori, M; Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Yoshida, K | 1 |
| Fujita, T; Nakai, H; Takano, K; Tanaka, T; Yonemasu, Y | 1 |
| Peters, DH; Sorkin, EM | 1 |
| Pimentel, J; Pinto, F | 1 |
| Kubota, F; Nakajima, M; Ohnishi, N; Shiihara, Y; Takahashi, S | 1 |
| Okada, M | 1 |
| Asoh, M; Shimohira, M | 1 |
| Patsalos, PN; Sander, JW | 1 |
| Arata, E; Kamijima, K; Kanba, S; Kinoshita, N; Koshikawa, H; Nibuya, M; Otaki, J; Suzuki, T; Tajima, O; Yagi, G | 1 |
| Eto, K; Furuno, K; Gomita, Y; Oishi, R | 1 |
| Matsunaga, Y; Mimaki, T; Mino, M; Miyazaki, H; Tanoue, H | 1 |
| Hirai, K; Kotani, H; Nishiki, T; Okano, S; Sawada, T; Takeuchi, Y; Yamazoe, I; Yoshioka, H | 1 |
| Hattori, H; Hayakawa, T; Higuchi, Y; Nigami, H | 1 |
| Leppik, IE | 5 |
| Karasawa, T; Masuda, Y; Noguchi, H | 1 |
| Hashimoto, Y; Hori, R; Odani, A; Okuno, T; Tanigawara, Y; Yasuhara, M | 1 |
| Miura, H | 3 |
| Hirai, K; Kumagai, N; Seki, T; Takuma, Y; Yamada, T | 1 |
| Asai, N; Hamanaka, T; Hiyoshi, T; Hori, S; Ishikawa, T; Mochizuki, H; Tsuji, M | 1 |
| Fukushima, Y; Hirano, T; Kaneko, S; Kondo, T; Okada, M; Otani, K | 1 |
| Shields, WD | 1 |
| Bauer, G; Blankenhorn, V; Deisenhammer, E; Despland, A; Egli, M; Jacob, R; Klinger, D; Loiseau, P; Schmidt, D; Stenzel, E | 1 |
| Kitada, M; Kiuchi, M; Komiya, M; Nakasa, H; Ohmori, S; Rikihisa, T | 1 |
| Fromm, G; Homan, RW; Leppik, IE; Lesser, RP; Oommen, KJ; Penry, JK; Sackellares, JC; Smith, DB; Wallace, JD; Willmore, LJ | 1 |
| Karasawa, T; Masuda, Y | 1 |
| Ishizu, T | 1 |
| Ozawa, H; Sasaki, M; Sugai, K; Yano, H | 1 |
| Futagi, Y; Imai, K; Otani, K; Yanagihara, K | 1 |
| Hayakawa, F; Kuno, K; Okumura, A; Watanabe, K | 1 |
| Kitada, M; Nakasa, H; Ohmori, S | 1 |
| Kitamura, S; Sugihara, K; Tatsumi, K | 1 |
| Otsubo, K; Shuto, H | 1 |
| Akaho, R | 1 |
| Kito, M; Maehara, M; Watanabe, K | 1 |
| Bialer, M; Perucca, E | 1 |
| Ito, T; Kurokawa, M; Masuda, Y; Shimizu, M; Uno, H | 1 |
| Akita, M; Hasegawa, M; Hasegawa, T; Nabeshima, T; Shinoda, M | 1 |
| Lee, BI | 1 |
| Akasaki, Y; Nagase, F; Nagatomo, I; Nomaguchi, M; Takigawa, M | 1 |
| Chadwick, DW; Kadir, ZA; Marson, AG | 1 |
| Chadwick, DW; Kadir, Z; Marson, T | 1 |
| Amano, Y; Egawa, I; Kaneko, S; Kondo, T | 1 |
| Grippo, J | 1 |
| Fukushima, Y; Hirano, T; Kaneko, S; Kondo, T; Mizuno, K; Okada, M; Otani, K | 1 |
| Fukui, M; Higuchi, S; Ieiri, I; Kim, S; Morioka, T; Nishio, S | 1 |
| Eguchi, T; Fujita, N; Kishi, T; Ueda, K | 1 |
| Akasaki, Y; Nagatomo, I; Takigawa, M; Uchida, M | 1 |
| Mizuno, K | 1 |
| Dejima, S; Hara, T; Maeoka, Y; Takeshita, K | 1 |
| Kitamura, S; Kuwasako, M; Sugihara, K; Tatsumi, K | 1 |
| Kato, H; Matsuishi, T; Ohnishi, A; Satoi, M; Shimizu, T; Togo, A; Wada, N; Yamashita, Y | 1 |
| Higuchi, S; Mishima, M; Nagatomi, A; Ohdo, S; Tsuzuki, O | 1 |
| Futagami, K; Goto, Y; Kataoka, Y; Makino, K; Oishi, R; Sueyasu, M | 1 |
| Howlett, W; Ijaz, S; Miyashita, H; Owen, AJ; Shuaib, A; Wishart, T | 1 |
| Ben-Menachem, E; Kyllerman, M | 1 |
| Wallace, SJ | 1 |
| Kawasaki, J; Mima, T; Saida, K; Shibasaki, H; Takigawa, T | 1 |
| Buchanan, RA; Kochak, GM; Padgett, CS; Page, JG; Peters, R | 1 |
| Akasaki, Y; Kuchiiwa, S; Nagatomo, I; Nakagawa, S; Takigawa, M; Uchida, M | 1 |
| Chadwick, DW; Hutton, JL; Kadir, ZA; Marson, AG | 1 |
| Fujitani, B; Kikuta, C; Masuda, Y; Minato, H | 1 |
| Abe, J; Imai, K; Nagai, T; Okada, S; Ono, J; Otani, K; Shiomi, M; Suzuki, Y; Tagawa, T | 1 |
| Mori, A; Noda, Y; Packer, L | 2 |
| Kitada, M; Kiuchi, M; Nakamura, H; Nakasa, H; Ohmori, S; Ono, S; Tsutsui, M | 1 |
| Kaneko, S; Kawata, Y; Kondo, T; Mizuno, K; Okada, M; Wada, K | 1 |
| Kimura, S | 1 |
| Akimitsu, T; Arita, K; Hamasaki, M; Hanaya, R; Hibino, S; Iida, K; Kurisu, K; Pant, B; Shinagawa, S | 1 |
| Fujioka, Y; Ohori, N; Ohta, M | 1 |
| Hagan, RM; Higgins, GA; Kirkby, D; Southam, E | 1 |
| Hattori, H; Ikeda, A; Kimura, J; Odani, A; Shibasaki, H | 1 |
| Mimaki, T | 1 |
| Cho, K; Iinuma, K; Kajii, N; Minami, T; Tachi, N | 1 |
| Hirano, T; Kaneko, S; Kawata, Y; Kondo, T; Mizuno, K; Murakami, T; Okada, M; Wada, K | 1 |
| Kawawaki, H; Murata, R; Shiraishi, K; Tomiwa, K | 1 |
| Hanai, T; Narazaki, O; Yanai, S | 1 |
| Kaneko, S; Kawata, Y; Kondo, T; Mizuno, K; Murakami, T; Okada, M; Wada, K | 1 |
| Ohkubo, T; Shimoyama, R; Sugawara, K | 1 |
| Araki, H; Futagami, K; Gomita, Y; Kawasaki, M; Matsuka, N; Nakatsuma, A; Watanabe, K | 1 |
| White, HS | 1 |
| Furukawa, S; Hayashi, T; Ichiyama, T; Isumi, H; Nishikawa, M; Yoshitomi, T | 1 |
| Perucca, E | 1 |
| Imai, K; Li, Z; Mano, T; Okada, S; Okinaga, T; Shimono, K; Ueda, H; Yanagihara, K | 1 |
| Kohsaka, M; Koyama, T; Miyamoto, T | 1 |
| Kanemoto, K; Kawasaki, J; Miyamoto, T | 1 |
| Gomita, Y; Hashimoto, Y; Kawasaki, H | 1 |
| Chadwick, DW; Marson, AG | 3 |
| Kawaguchi, H; Kubota, M; Nakamoto, M; Nishi-Nagase, M; Noma, S; Sakakihara, Y; Yanagisawa, M | 1 |
| Vajda, FJ | 1 |
| Hayakawa, F; Ishihara, N; Kato, T; Kuno, K; Okumura, A; Watanabe, K | 1 |
| Hiramatsu, M; Komatsu, M; Willmore, LJ | 1 |
| Kajiyama, M; Kishi, T; Nejihashi, Y; Ueda, K | 1 |
| Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M | 3 |
| Doi, T; Kamada, H; Mitsuyama, Y; Nakajima, A; Ohya-Nishiguchi, H; Tokumaru, J; Ueda, Y; Yokoyama, H | 1 |
| Abe, J; Ohno, M; Shimada, M; Shimotsuji, Y; Tamiya, H | 1 |
| Johannessen, SI; Nakken, KO; Rytter, E | 1 |
| Gondo, K; Hara, T; Ikeda, K; Inoue, T; Kaku, Y; Kira, R | 1 |
| Miyamoto, A; Okamoto, T; Oki, J; Shirai, M; Sugai, R | 1 |
| Jain, KK | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Kawakami, K; Suemaru, K; Yamamoto, T | 1 |
| Hirade, K; Katagiri, Y; Nakamura, M; Sugiyama, T | 1 |
| Akagawa, Y; Hosokawa, R; Kitamura, S; Ohta, S; Sugihara, K | 1 |
| Castillo, S; Chadwick, DW; Chaisewikul, R; Hutton, JL; Leach, JP; Marson, AG; Privitera, M; Schmidt, D; White, S | 1 |
| Kaneko, S; Murakami, T; Yoshimura, I; Yoshimura, N | 1 |
| Suzuki, Y | 1 |
| Kanazawa, O | 1 |
| Hidaka, Y; Hirose, Y; Kimura, M; Mutoh, K | 1 |
| Ayala, R; Faught, E; Leppik, IE; Montouris, GG | 1 |
| Traverse, LD | 1 |
| Horiuchi, E; Kanazawa, I; Murata, M | 1 |
| Akaike, K; Fukumoto, S; Imamura, S; Takigawa, M; Tanaka, S; Tojo, H | 1 |
| Hayakawa, F; Okumura, A; Sofue, A | 1 |
| Imai, K; Kagitani-Shimono, K; Okada, S; Okamoto, N; Ono, J | 1 |
| Biederman, TS; McAuley, JW; Moore, JL; Smith, JC | 1 |
| Ando, Y; Asai, S; Hotta, T; Kobayashi, H; Miyachi, H | 1 |
| Fujioka, T; Hakui, T; Hanada, K; Kondou, T; Mine, M; Seike, E; Sitaya, M; Tounou, S | 1 |
| Hamada, K; Ishida, S; Seino, M; Song, HK; Yagi, K | 1 |
| Ishii, M; Isobe, K; Itoh, S; Kawada, K; Kusaka, T | 1 |
| Wheless, JW | 1 |
| Kamata, A; Kaneko, S; Kawata, Y; Murakami, T; Okada, M; Zhu, G | 1 |
| Ariyoshi, N; Igarashi, T; Ishii, I; Kitada, M; Nakamura, H; Nakasa, H; Ohmori, S | 1 |
| Glauser, TA; Pellock, JM | 1 |
| Calabrese, JR; Kroeker, G; Kusumakar, V; Rao, R; Scarrow, G; Yatham, LN | 1 |
| Abe, J; Arai, H; Fujikawa, Y; Imai, K; Mano, T; Matsuoka, T; Morita, Y; Nagai, T; Okada, S; Okinaga, T; Ono, J; Shimono, K; Suzuki, Y; Tagawa, T; Toribe, Y; Ueda, H; Yanagihara, K | 1 |
| Haruda, FD | 1 |
| Amano, S; Ihara, N; Miura, Y; Torii, R | 1 |
| Boon, PA; van Rijckevorsel, K | 1 |
| Backonja, MM | 1 |
| Hayashi, K; Jo, K; Katsumori, H; Nagafuchi, H; Oguni, H; Osawa, M; Saito, Y; Yanagaki, S | 1 |
| Kurokawa, T | 1 |
| Hirai, K; Jozaki, K; Kimiya, S; Kumagai, N; Seki, T; Tabata, K | 1 |
| Ishiguro, N; Itoh, T; Kikuta, H; Kobayashi, K; Kodaira, J; Ma, X; Yoshioka, M | 1 |
| Kanba, S; Miyaoka, H; Nakaki, T; Shintani, F; Suzuki, E | 1 |
| Hirose, S; Kanai, K; Kaneko, S; Okada, M; Yoshida, S; Zhu, G | 1 |
| Sirven, JI | 1 |
| Berigan, TR | 1 |
| Alldredge, BK; Chen, JT; Garcia, PA | 1 |
| Bergin, AM; Connolly, M | 1 |
| Shelton, RC | 1 |
| Araki, H; Futagami, K; Gomita, Y; Hashimoto, Y; Kawasaki, H | 1 |
| Franciscy, DM; Gadde, KM; Krishnan, KR; Wagner, HR | 1 |
| Kamei, J; Mayanagi, H; Miyazaki, S; Onodera, K; Saito, T; Sakurada, S; Shinoda, H; Takahashi, A | 1 |
| Haginoya, K; Hirose, M; Iinuma, K; Yokoyama, H | 1 |
| Azevedo, MI; Chalfoun, AG; Denson, DD; Hord, AH | 1 |
| Kapcala, LP; Knudsen, JF; Racoosin, JA; Thambi, LR | 1 |
| Bond, GR; Huang, EE; Sztajnkrycer, MD | 1 |
| Johannessen, SI; Perucca, E | 1 |
| Doi, T; Tokumaru, J; Ueda, Y; Willmore, LJ | 1 |
| Kohmoto, J; Kondo, T; Miwa, H; Nakanishi, I | 1 |
| Go, T | 1 |
| Fukuoka, N; Kimura, M; Morita, S; Tsukamoto, T; Uno, J | 2 |
| Iyo, M; Kobayashi, K; Noda, S; Ozawa, K | 1 |
| Hudson, JI; Keck, PE; Kotwal, R; McElroy, SL; Nelson, EB | 1 |
| Lotze, TE; Wilfong, AA | 1 |
| Helmers, SL; LaRoche, SM | 1 |
| Murata, M | 6 |
| Fujiwara, T; Iinuma, K | 1 |
| Abou-Khalil, B; Bautista, J; Bazil, C; Bergen, D; Beydoun, A; Bourgeois, B; Browne, T; Faught, RE; Fischer, JH; French, JA; Gidal, B; Glauser, TA; Harden, CL; Hirtz, D; Kanner, AM; Marks, WJ; Montouris, GD; Nespeca, M; Sachdeo, RC; Schachter, SC; Stern, J; Theodore, WH; Turk, WR; Wilner, A | 3 |
| Hashimoto, K; Takahashi, Y; Tsuji, S | 1 |
| Dubinsky, S; Newmark, ME | 1 |
| Knudsen, JF; Racoosin, JA | 1 |
| Hasegawa, H | 1 |
| Browne, TR; Ramsay, RE; Sackellares, JC; Shellenberger, MK; Wilder, BJ | 1 |
| Gluck, MR; Granson, H; Santana, LA; Yahr, MD | 1 |
| Anthony, S; James, SP; Miller, GS; Montouris, G; Uthman, BM | 1 |
| Yatham, LN | 1 |
| Fukuda, F; Ijiri, Y; Inoue, T; Kobayashi, T; Shibahara, N; Suzuki, K; Takenaka, H; Tanaka, K | 1 |
| Conry, JA | 1 |
| Baldassano, CF; Chang, A; Ghaemi, SN; Lipari, M; Lyman, A | 1 |
| Garnett, WR; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Rosenfeld, W; Schmerler, M; Shah, J | 1 |
| Yagi, K | 1 |
| Seino, M | 1 |
| Kumagai, N; Maezawa, M; Seki, T | 1 |
| Haginoya, K; Iinuma, K | 1 |
| Aikawa, H; Yamauchi, T | 1 |
| Ohtahara, S; Yamatogi, Y | 2 |
| Willmore, LJ | 2 |
| Faught, E | 1 |
| Brodie, MJ | 2 |
| Bergen, D; Garnett, W; Grundy, JS; Levy, RH; Mather, G; Ragueneau-Majlessi, I; Rosenfeld, W; Shah, J | 1 |
| James, S; Leong, R; Low, PA; Peschel, T; Rothstein, A | 1 |
| Frediani, F | 1 |
| Guay, DR | 1 |
| Szaflarski, JP | 1 |
| Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I | 1 |
| Majeres, KD; Suppes, T | 1 |
| Bitenskyy, V; Brodie, MJ; Duncan, R; Lucas, C; Solyom, A; Vespignani, H | 1 |
| Wilfong, AA | 1 |
| Kamei, J; Mayanagi, H; Onodera, K; Saito, T; Takahashi, A | 1 |
| Anand, A; Bukhari, L; Jennings, SA; Kamat, M; Lee, C; Lightfoot, J; Nurnberger, JI; Shekhar, A | 1 |
| Pucci, V; Raggi, MA | 1 |
| Richards, KC; Smith, MC; Verma, A | 1 |
| Kondo, T; Miwa, H; Morita, S | 1 |
| Brodie, MJ; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Shah, J; Smith, DF | 1 |
| Frampton, JE; Scott, LJ | 1 |
| Dai, Y; Griffith, SG | 1 |
| Aldridge, J; Kim, HL; Rho, JM | 1 |
| Antel, J; Casini, A; De Simone, G; Di Fiore, A; Menchise, V; Pedone, C; Scozzafava, A; Supuran, CT; Wurl, M | 1 |
| Biton, V | 1 |
| Funatsuka, M; Hayashi, K; Imai, K; Oguni, H; Osawa, M; Yanagaki, S; Yoshii, K | 1 |
| Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D | 1 |
| Brotherton, T; Santos, CC | 1 |
| Altshuler, LL; Black, D; Frye, MA; Grunze, H; Keck, PE; Kupka, RW; Leverich, GS; McElroy, SL; Nolen, WA; Post, RM; Suppes, T; Walden, J | 1 |
| Dai, J; Ichikawa, J; Meltzer, HY | 1 |
| Howland, RH | 1 |
| Bunch, M; Kugler, SL; Mandelbaum, DE; Venkatasubramanian, A; Wollack, JB | 2 |
| Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Song, HK; Won, MH | 1 |
| Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M | 1 |
| Kaneko, S; Okada, M; Yoshida, S; Zhu, G | 1 |
| Doi, T; Nagatomo, K; Nakajima, A; Tokumaru, J; Ueda, Y | 1 |
| Masumizu, T; Mori, A; Noda, Y; Packer, L | 1 |
| Ohtahara, S | 1 |
| Zareba, G | 1 |
| Baulac, M | 1 |
| Cheskin, LJ; Sidhaye, A | 1 |
| Polesin, A; Stern, M | 1 |
| Tisdell, J; Tosches, WA | 1 |
| Li, J; Wu, G; Zhu, Y | 1 |
| Hamano, S; Imai, K; Motohashi, S; Sato, M; Yoshida, T | 1 |
| Kring, D; Pakalnis, A | 1 |
| Hobdell, E; Kaleyias, J; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Mostofi, N; Valencia, I | 1 |
| Anzai, Y; Hayashi, M; Ohya, T | 1 |
| Kuribayashi, Y; Onodera, K; Takahashi, A | 1 |
| Baldassano, CF; Dunn, RT; Filkowski, MM; Ghaemi, SN; Isenstein, E; Pardo, TB; Zablotsky, B | 1 |
| Sullivan, KL; Ward, CL; Zesiewicz, TA | 1 |
| Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sobieszek, G | 1 |
| Ashkenazi, A; Benlifer, A; Korenblit, J; Silberstein, SD | 1 |
| Arzimanoglou, A; Rahbani, A | 1 |
| Feuerstein, TJ; Stefan, H | 1 |
| Johannessen, SI; Tomson, T | 1 |
| Cohen, AF; van Bronswijk, H | 1 |
| Fukushima, K; Seino, M | 1 |
| Chalasani, N; Saxena, R; Vuppalanchi, R | 1 |
| Arinami, T; Hasegawa, M; Kamoda, T; Kanemoto, K; Kanemoto, N | 1 |
| Hauser, RA; Sanchez-Ramos, J; Staffetti, JF; Sullivan, KL; Ward, CL; Zesiewicz, TA | 1 |
| Keck, PE; Kotwal, R; McElroy, SL | 1 |
| Clouse, RE; Lustman, PJ; Prakash, C; Sayuk, GS | 1 |
| Findling, RL; Wilson, MS | 1 |
| D'Alessio, DA; Guerdjikova, AI; Hudson, JI; Keck, PE; Kotwal, R; Lake, KA; McElroy, SL; Nelson, EB; Welge, JA | 1 |
| Hasegawa, K; Kanazawa, I; Murata, M | 1 |
| Doi, T; Kato, T; Nikaido, K; Takayama, R | 1 |
| Greiner-Sosanko, E; Krasowski, MD; Lower, DR; Virji, MA | 1 |
| Huang, CC; Huang, CW; Wu, SN | 1 |
| Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC | 1 |
| Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N | 1 |
| Matsuura, M | 1 |
| Brodie, M; Sills, G | 1 |
| Rambeck, B; Tipold, A; von Klopmann, T | 1 |
| Kano, Y; Sakuma, K; Shiohara, T | 1 |
| Michael, CT; Starr, JL | 1 |
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| Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H | 1 |
| Apartis, E; Azulay, JP; Bissery, A; Bonnet, C; Brochard, V; Charbonnier-Beaupel, F; Clot, F; Corvol, JC; Cozic, N; Degos, B; Doe De Maindreville, A; Drapier, S; Dupont, S; Glibert, G; Grabli, D; Hainque, E; Hubsch, C; Lebouvier, T; Legrand, AP; Mallet, A; Méneret, A; Mutez, E; Roze, E; Thobois, S; Tranchant, C; Vidailhet, M; Zahr, N | 1 |
| Chervoneva, I; Miller, R; Mintzer, S; Nei, M; Shah, K; Skidmore, C; Sperling, MR | 1 |
| Alayari, A; Anderson, K; Hussain, SA; Lay, J; Rajaraman, RR; Sankar, R | 1 |
| Yamamoto, T | 1 |
| Arai, H; Kodama, K; Omata, T; Tanabe, Y | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| McStay, C; Pierce, R; Riley, C | 1 |
| Masumizu, T; Mori, A; Noda, Y | 1 |
| Maniruzzaman, M; Nokhodchi, A; Shojaee, S | 1 |
| Boothe, DM; Hodshon, AJ; Michaels, JR; Thomas, WB; Williams, L | 1 |
| Iwata, N; Kishi, T; Matsunaga, S | 1 |
| Burdett, J; Duncan, JS; Hill, A; Koepp, MJ; Thompson, PJ; Townsend, L; Wandschneider, B | 1 |
| Asada, T; Itai, S; Iwao, Y; Kobiki, M; Ochiai, Y | 1 |
| Kordala, A; Krupa-Burtnik, A; Pietrzak, B; Zwierzynska, E | 1 |
| Cowley, MA; Oldfield, BJ; Stefanidis, A; Watt, MJ | 1 |
| Chen, Y; Deng, J; Fu, J; Guo, G; Li, J; Li, X; Tong, A; Wang, Y; Yuan, J | 1 |
| Coppola, G; Operto, FF; Piccorossi, A; Verrotti, A | 1 |
| Lee, JW; Nicolas, J; Sarkis, RA | 1 |
| Hashizume, T; Kaneko, S; Kusaka, H; Morise, S; Nakamura, M; Oki, M; Takenouchi, N; Tsuge, A; Wate, R | 1 |
| Asano, T; Hikawa, R; Takahashi, R; Uemura, MT; Yamakado, H | 1 |
| Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J | 2 |
| Garcia-Estevez, DA; Pardo-Parrado, M; Silvarrey-Rodriguez, S | 1 |
| Barary, MA; El-Yazbi, AF; Ibrahim, FA; Wagih, MM | 1 |
| Bruno, E; Colosimo, C; Filippini, G; Nicoletti, A; Quattrocchi, G; Zappia, M | 1 |
| Doğan, EA; Erdoğan, Ç; Genç, BO; Genç, E | 1 |
| Collinet, A; Sammut, V | 1 |
| Conejo-Moreno, D; Gutierrez-Alvarez, AM; Jimenez-Corral, C; Ortiz-Madinaveitia, S; Sagarra-Mur, D; Serrano-Madrid, ML | 1 |
| Kollár, K; Mellár, M; Móser, J; Rosdy, B | 1 |
| Alves, G; Bicker, J; Falcão, A; Fortuna, A; Gonçalves, J | 1 |
| Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B | 1 |
| Juhos, V | 1 |
| Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J | 2 |
| Heo, K; Ki, CS; Kim, KH; Park, CW; Song, JS | 1 |
| Bhattacharya, P; Borah, A; Chakrabarty, J; Dutta, A; Mazumder, MK; Paul, R; Phukan, BC | 1 |
| Ouyang, Y; Song, Z; Xiao, X; Zheng, W | 1 |
| Borobia, AM; Carcás Sansuan, AJ; Dapía, I; Díaz, L; Frías, J; García Bartolomé, A; García, I; Guerra, P; Martínez-Ávila, JC; Tong, HY | 1 |
| Eadie, MJ; Lander, CM; O'Brien, TJ; Perucca, P; Vajda, FJE | 1 |
| Brandifino, M; Sinnott-Stutzman, V; Sisson, A; Whelan, M | 1 |
131 review(s) available for isoxazoles and zonisamide
| Article | Year |
|---|---|
Zonisamide.
Topics: Animals; Anticonvulsants; Brain; Drugs, Investigational; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Isoxazoles; Zonisamide | 1991 |
Neuropharmacology of zonisamide, a new antiepileptic drug.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbonic Anhydrase Inhibitors; Drug Interactions; Epilepsy; Isoxazoles; Kinetics; Oxazoles; Zonisamide | 1987 |
Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Zonisamide | 1993 |
[New antiepileptic medications].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Triazines; Vigabatrin; Zonisamide | 1995 |
[Excitatory psychic symptoms induced by zonisamide in six cases of brain damages].
Topics: Adolescent; Anticonvulsants; Brain; Brain Damage, Chronic; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Stimulation, Chemical; Zonisamide | 1995 |
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Topics: Acetamides; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Piracetam; Propylene Glycols; Risk Factors; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1994 |
Antiepileptic drugs in development: prospects for the near future.
Topics: Acetates; Adult; Amines; Aminocaproates; Animals; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Drug Design; Drugs, Investigational; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Triazines; Vigabatrin; Zonisamide | 1994 |
Investigational antiepileptic drugs for the treatment of childhood seizure disorders: a review of efficacy and safety.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Clinical Trials as Topic; Clobazam; Drug Design; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Triazines; Zonisamide | 1994 |
[Zonisamide].
Topics: Anticonvulsants; Drug Monitoring; Humans; Isoxazoles; Zonisamide | 1995 |
The clinical pharmacokinetics of the newer antiepileptic drugs. Focus on topiramate, zonisamide and tiagabine.
Topics: Anticonvulsants; Drug Interactions; Fructose; Half-Life; Humans; Isoxazoles; Nipecotic Acids; Tiagabine; Topiramate; Zonisamide | 1996 |
[Research and development of zonisamide, a new type of antiepileptic drug].
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Dogs; Drug Design; Electroencephalography; Epilepsy; Humans; Isoxazoles; Mice; Rabbits; Rats; Structure-Activity Relationship; Zonisamide | 1996 |
New antiepileptic drugs. II. Clinical use.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Felbamate; Forecasting; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Topiramate; Triazines; Vigabatrin; Zonisamide | 1996 |
New antiepileptic drugs: a systematic review of their efficacy and tolerability.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cross-Over Studies; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Male; Middle Aged; Nipecotic Acids; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 1996 |
Clinical administration of new antiepileptic drugs: an overview of safety and efficacy.
Topics: Acetates; Amines; Anticonvulsants; Confidence Intervals; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Odds Ratio; Placebos; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 1996 |
[Treatment of the epilepsy: new drugs].
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Topiramate; Triazines; Vigabatrin; Zonisamide | 1996 |
Myoclonus and epilepsy in childhood: a review of treatment with valproate, ethosuximide, lamotrigine and zonisamide.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Ethosuximide; Humans; Infant; Isoxazoles; Lamotrigine; Triazines; Valproic Acid; Zonisamide | 1998 |
The new antiepileptic drugs: a systematic review of their efficacy and tolerability.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Male; Middle Aged; Randomized Controlled Trials as Topic; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 1997 |
Clinical pharmacology and therapeutic drug monitoring of zonisamide.
Topics: Animals; Anticonvulsants; Drug Interactions; Drug Monitoring; Humans; Isoxazoles; Zonisamide | 1998 |
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fructose; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Receptors, GABA; Sodium Channels; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1999 |
Zonisamide.
Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 1999 |
The clinical pharmacokinetics of the new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Zonisamide | 1999 |
Zonisamide for drug-resistant partial epilepsy.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Treatment Failure; Zonisamide | 2000 |
New antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
[Adverse effects of antiepileptic agents].
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clobazam; Cyclohexanecarboxylic Acids; Drug Utilization; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Norway; Piracetam; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
An assessment of zonisamide as an anti-epileptic drug.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Female; Humans; Isoxazoles; Middle Aged; Pregnancy; Zonisamide | 2000 |
Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review.
Topics: Acetamides; Anticonvulsants; Carbamazepine; Controlled Clinical Trials as Topic; Drug Resistance; Epilepsies, Partial; Humans; Isoxazoles; Levetiracetam; Linear Models; Logistic Models; Oxcarbazepine; Piracetam; Zonisamide | 2001 |
Zonisamide in West syndrome.
Topics: Anticonvulsants; Electroencephalography; Humans; Infant; Isoxazoles; Spasms, Infantile; Zonisamide | 2001 |
Refractory grand mal seizures with onset during infancy including severe myoclonic epilepsy in infancy.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Humans; Infant; Isoxazoles; Zonisamide | 2001 |
Newer therapies in the drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Piracetam; Zonisamide | 2002 |
Three new drugs for epilepsy: levetiracetam, oxcarbazepine, and zonisamide.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Piracetam; Treatment Outcome; Zonisamide | 2002 |
Using the new antiepilepsy drugs in children.
Topics: Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Piracetam; Treatment Outcome; Zonisamide | 2002 |
Zonisamide in pediatric epilepsy: review of the Japanese experience.
Topics: Adult; Anticonvulsants; Child; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Japan; Treatment Outcome; Zonisamide | 2002 |
Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Double-Blind Method; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Placebos; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
Zonisamide add-on for drug-resistant partial epilepsy.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Treatment Failure; Zonisamide | 2002 |
Use of anticonvulsants for treatment of neuropathic pain.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nervous System Diseases; Pain; Phenytoin; Triazines; Zonisamide | 2002 |
Exocytosis mechanism as a new targeting site for mechanisms of action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Exocytosis; Humans; Isoxazoles; Microdialysis; Neurotransmitter Agents; Serotonin; Zonisamide | 2002 |
Antiepileptic drug therapy for adults: when to initiate and how to choose.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Recurrence; Risk Factors; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
New antiepileptic drug therapies.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Phenytoin; Piracetam; Propylene Glycols; Thiazines; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
Treating bipolar depression.
Topics: Acetates; Affect; Amines; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium Compounds; Nipecotic Acids; Olanzapine; Oxcarbazepine; Pirenzepine; Tiagabine; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2003 |
Oligohydrosis and fever in pediatric patients treated with zonisamide.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Child; Child, Preschool; Female; Fever; Humans; Hypohidrosis; Infant; Isoxazoles; Male; Zonisamide | 2003 |
The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2003 |
The new antiepileptic drugs: scientific review.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Zonisamide | 2004 |
Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Biogenic Monoamines; Calcium Channels, T-Type; Humans; Isoxazoles; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Randomized Controlled Trials as Topic; Treatment Outcome; Zonisamide | 2004 |
[Clinical guidelines for treatment of epilepsy in children].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Isoxazoles; Life Style; Magnetic Resonance Imaging; Phenytoin; Practice Guidelines as Topic; Temporal Lobe; Valproic Acid; Zonisamide | 2004 |
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Antipsychotic Agents; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; United States; United States Food and Drug Administration; Zonisamide | 2004 |
Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsies, Partial; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Practice Patterns, Physicians'; Tiagabine; Topiramate; Triazines; United States; United States Food and Drug Administration; Zonisamide | 2004 |
Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epile
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Resistance; Epilepsies, Partial; Epilepsy, Generalized; Evidence-Based Medicine; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2004 |
Newer anticonvulsants in the treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Depressive Disorder; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenytoin; Piracetam; Pregabalin; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2004 |
Pharmacologic treatment of the catastrophic epilepsies.
Topics: Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Fructose; Humans; Infant; Isoxazoles; Lamotrigine; Spasms, Infantile; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 2004 |
Review of zonisamide development in Japan.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Japan; Product Surveillance, Postmarketing; Zonisamide | 2004 |
Zonisamide: chemistry, mechanism of action, and pharmacokinetics.
Topics: Animals; Anticonvulsants; Area Under Curve; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hydroxyl Radical; Isoxazoles; Nitric Oxide; Zonisamide | 2004 |
Zonisamide overview of the United States experience.
Topics: Anticonvulsants; Epilepsy; Humans; Isoxazoles; Retrospective Studies; United States; Zonisamide | 2004 |
Review of United States and European clinical trials of zonisamide in the treatment of refractory partial-onset seizures.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsies, Partial; Europe; Humans; Isoxazoles; Kidney Calculi; Meta-Analysis as Topic; Severity of Illness Index; Time Factors; United States; Zonisamide | 2004 |
Zonisamide and associated oligohidrosis and hyperthermia.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Child; Fever; Humans; Hyperhidrosis; Isoxazoles; Zonisamide | 2004 |
Anticonvulsant drugs in primary headaches prophylaxis.
Topics: Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Headache; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Topiramate; Triazines; Valproic Acid; Vigabatrin; Zonisamide | 2004 |
Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain.
Topics: Aged; Analgesics, Non-Narcotic; Animals; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fructose; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Pain; Peripheral Nervous System Diseases; Piracetam; Topiramate; Zonisamide | 2003 |
Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography.
Topics: Acetazolamide; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Felbamate; Humans; Hydantoins; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Succinimides; Triazines; Valproic Acid; Vigabatrin; Zonisamide | 2005 |
Zonisamide: a review of its use in the management of partial seizures in epilepsy.
Topics: Anticonvulsants; Disease Management; Epilepsies, Partial; Humans; Isoxazoles; Zonisamide | 2005 |
Zonisamide: newer antiepileptic agent with multiple mechanisms of action.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Epilepsy; Follow-Up Studies; History, 20th Century; History, 21st Century; Humans; Isoxazoles; Neuroprotective Agents; Zonisamide | 2004 |
Anticonvulsant drug therapies.
Topics: Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Depressive Disorder; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nurse's Role; Oxcarbazepine; Patient Selection; Safety; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2005 |
Zonisamide add-on for drug-resistant partial epilepsy.
Topics: Anticonvulsants; Drug Resistance; Epilepsies, Partial; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Treatment Failure; Zonisamide | 2005 |
Antiepileptic drugs and neuroprotection: current status and future roles.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Neuroprotective Agents; Piracetam; Seizures; Topiramate; Triazines; Zonisamide | 2005 |
Zonisamide as adjunctive therapy for refractory partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 2006 |
Zonisamide in the management of epilepsy--Japanese experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Japan; Zonisamide | 2006 |
Zonisamide: review of its use in epilepsy therapy.
Topics: Animals; Anticonvulsants; Biological Availability; Child; Child, Preschool; Drug Interactions; Epilepsy; Half-Life; Humans; Infant; Isoxazoles; Migraine Disorders; Pain; Parkinson Disease; Randomized Controlled Trials as Topic; Tissue Distribution; Zonisamide | 2005 |
Practical prescribing and long-term efficacy and safety of zonisamide.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 2006 |
Introduction to zonisamide.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsies, Partial; Humans; Isoxazoles; Zonisamide | 2006 |
Pharmacologic treatment of obesity.
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Fructose; Humans; Isoxazoles; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Selective Serotonin Reuptake Inhibitors; Topiramate; Zonisamide | 2006 |
Zonisamide for the treatment of epilepsy.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Practice Patterns, Physicians'; Treatment Outcome; Zonisamide | 2006 |
Novel anticonvulsant drugs.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Piracetam; Pregabalin; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2007 |
Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Monitoring; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Pregabalin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2006 |
Comorbidity of eating disorders with bipolar disorder and treatment implications.
Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Comorbidity; Disruptive, Impulse Control, and Conduct Disorders; Feeding and Eating Disorders; Fructose; Humans; Isoxazoles; Topiramate; Zonisamide | 2006 |
Zonisamide for bipolar depression.
Topics: Bipolar Disorder; Humans; Isoxazoles; Pilot Projects; Zonisamide | 2007 |
[Newer antiepileptic drugs].
Topics: Amines; Animals; Anti-Anxiety Agents; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Approval; Drug Design; Drug Interactions; Epilepsy; Felbamate; Fructose; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Neuroprotective Agents; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Sodium Channel Blockers; Topiramate; Triazines; Zonisamide | 2007 |
Pharmacokinetics and drug interactions with zonisamide.
Topics: Anticonvulsants; Contraceptives, Oral; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Epilepsy; Half-Life; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 2007 |
Antiobesity carbonic anhydrase inhibitors.
Topics: Anti-Obesity Agents; Carbonic Anhydrase Inhibitors; Fructose; Humans; Isoxazoles; Lipogenesis; Sulfonamides; Topiramate; Zonisamide | 2007 |
Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures.
Topics: Animals; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Resistance; Epilepsies, Partial; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Zonisamide | 2007 |
[Neuromuscular disorders caused by adverse effects of antiepileptics].
Topics: Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Neuromuscular Diseases; Phenobarbital; Phenytoin; Topiramate; Valproic Acid; Zonisamide | 2007 |
Zonisamide for the treatment of Parkinson's disease.
Topics: Anticonvulsants; Antiparkinson Agents; Brain; Clinical Trials as Topic; Humans; Isoxazoles; Parkinson Disease; Treatment Outcome; Zonisamide | 2007 |
The new antiepileptic drugs.
Topics: Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsies, Partial; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Pregabalin; Topiramate; Triazines; Vigabatrin; Zonisamide | 2007 |
Emerging concepts in the medical and surgical treatment of obesity.
Topics: Adipose Tissue; Amyloid; Anticonvulsants; Antidepressive Agents; Anxiety; Appetite Regulation; Bariatric Surgery; Body Mass Index; Bupropion; Cholecystokinin; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Cyclobutanes; Depression; Diabetes Mellitus, Type 2; Female; Fluoxetine; Fructose; Ghrelin; Humans; Intra-Abdominal Fat; Islet Amyloid Polypeptide; Isoxazoles; Lactones; Leptin; Metabolic Syndrome; Metformin; Obesity; Obesity, Morbid; Orlistat; Oxyntomodulin; Peptide YY; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant; Sertraline; Sleep Apnea, Obstructive; Surgical Procedures, Operative; Topiramate; Zonisamide | 2008 |
Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Brain Diseases; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Mental Disorders; Treatment Outcome; Zonisamide | 2008 |
Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.
Topics: Anti-Obesity Agents; Carbonic Anhydrase Inhibitors; Cytosol; Fructose; Humans; Isoxazoles; Mitochondria; Obesity; Topiramate; Zonisamide | 2008 |
Therapeutic role of zonisamide in neuropsychiatric disorders.
Topics: Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Psychotic Disorders; Retrospective Studies; Zonisamide | 2008 |
[Therapy of Parkinson's disease--up to date].
Topics: Anticonvulsants; Antiparkinson Agents; Carbazoles; Dopamine Agents; Dopamine Agonists; Drug Design; Genetic Therapy; Humans; Isoxazoles; Levodopa; Neuroprotective Agents; Parkinson Disease; Randomized Controlled Trials as Topic; Substantia Nigra; Zonisamide | 2008 |
[Role of monotherapy with new antiepileptic drugs in the treatment of childhood epilepsy].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Topiramate; Triazines; Zonisamide | 2009 |
[Pharmacologic treatment of Parkinson disease].
Topics: Age of Onset; Antiparkinson Agents; Dopamine Agonists; Glutathione; Humans; Isoxazoles; Levodopa; Neuroprotective Agents; Parkinson Disease; Superoxide Dismutase; Zonisamide | 2009 |
New pharmacotherapies for pediatric seizures.
Topics: Adolescent; Amines; Animals; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Pediatrics; Piracetam; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 2004 |
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Generalized; Female; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Male; Myoclonic Epilepsy, Juvenile; Piracetam; Pregnancy; Risk Assessment; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Weight Gain; Zonisamide | 2009 |
Zonisamide in the treatment of epilepsy.
Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Compassionate Use Trials; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Europe; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Syndrome; Treatment Outcome; Zonisamide | 2010 |
[Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases].
Topics: Anticonvulsants; Bipolar Disorder; Calcium Channels, T-Type; Cholinergic Agents; Dopamine Agents; Dyskinesias; Epilepsy; Excitatory Amino Acid Agents; Feeding and Eating Disorders; GABA Agents; Humans; Isoxazoles; Migraine Disorders; Nerve Tissue Proteins; Nervous System Diseases; Neuroprotective Agents; Obesity; Parkinson Disease; Randomized Controlled Trials as Topic; Sodium Channels; Treatment Outcome; Voltage-Gated Sodium Channel beta-2 Subunit; Zonisamide | 2009 |
[The discovery of an antiparkinsonian drug, zonisamide].
Topics: Animals; Anticonvulsants; Dopamine; Humans; Isoxazoles; Male; Middle Aged; Parkinson Disease; Rats; Zonisamide | 2010 |
Drug safety evaluation of zonisamide for the treatment of epilepsy.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Isoxazoles; Kidney Calculi; Mental Disorders; Randomized Controlled Trials as Topic; Zonisamide | 2011 |
[Discovery of an antiparkinsonian drug: zonisamide].
Topics: Animals; Antiparkinson Agents; Calcium Channels, T-Type; Clinical Trials as Topic; Corpus Striatum; Dopamine; Drug Approval; Drug Discovery; Genome-Wide Association Study; Humans; Isoxazoles; Japan; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Precision Medicine; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
Zonisamide in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Epilepsy; Humans; Isoxazoles; Sodium Channel Blockers; Zonisamide | 2011 |
Novel treatment options of binge eating disorder.
Topics: Anticonvulsants; Binge-Eating Disorder; Fructose; Ghrelin; Humans; Isoxazoles; Narcotic Antagonists; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors; Topiramate; Zonisamide | 2011 |
Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide.
Topics: Animals; Anticonvulsants; Drug Therapy, Combination; Fructose; Humans; Isoxazoles; Risk Assessment; Risk Factors; Topiramate; Weight Loss; Zonisamide | 2012 |
[New drugs in the treatment of adult patients with refractery epilepsy].
Topics: Adult; Anticonvulsants; Dibenzazepines; Epilepsy; Humans; Isoxazoles; Zonisamide | 2011 |
Zonisamide: its pharmacology, efficacy and safety in clinical trials.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 2012 |
Zonisamide in clinical practice.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Quality of Life; Seizures; Treatment Outcome; Zonisamide | 2012 |
Latest advancements in the pharmacological treatment of binge eating disorder.
Topics: Binge-Eating Disorder; Female; Fructose; Ghrelin; Humans; Isoxazoles; Topiramate; Zonisamide | 2012 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2013 |
[Epilepsy in the elderly].
Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Quality of Life; Seizures; Triazines; Zonisamide | 2013 |
[Zonisamide in the epilepsy treatment: a literature review from add-on therapy to monotherapy].
Topics: Adult; Animals; Anorexia; Anticonvulsants; Antioxidants; Carbonic Anhydrase Inhibitors; Child; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Europe; Fatigue; Headache; Humans; Ion Channels; Isoxazoles; Multicenter Studies as Topic; Neurotransmitter Agents; Randomized Controlled Trials as Topic; United States; Zonisamide | 2013 |
Antiobesity carbonic anhydrase inhibitors: a literature and patent review.
Topics: Animals; Anti-Obesity Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Drug Design; Fructose; Humans; Isoxazoles; Lipogenesis; Mitochondria; Molecular Targeted Therapy; Obesity; Patents as Topic; Topiramate; Zonisamide | 2013 |
Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults.
Topics: Anticonvulsants; Drug Administration Schedule; Epilepsies, Partial; Humans; Isoxazoles; Zonisamide | 2013 |
The adverse event profile of zonisamide: a meta-analysis.
Topics: Anticonvulsants; Clinical Trials as Topic; Databases, Factual; Epilepsy; Humans; Isoxazoles; Zonisamide | 2013 |
Zonisamide: a review of its use in the management of adults with partial seizures.
Topics: Adult; Aged; Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Middle Aged; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome; Young Adult; Zonisamide | 2013 |
Zonisamide add-on for drug-resistant partial epilepsy.
Topics: Anticonvulsants; Drug Resistance; Drug Therapy, Combination; Epilepsies, Partial; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Treatment Failure; Zonisamide | 2013 |
Zonisamide as a treatment for partial epileptic seizures: a systematic review.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 2014 |
Zonisamide: a review of its use as adjunctive therapy in the management of partial seizures in pediatric patients aged ≥6 years.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Partial; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 2014 |
The risk and management of kidney stones from the use of topiramate and zonisamide in migraine and idiopathic intracranial hypertension.
Topics: Adult; Anticonvulsants; Female; Fructose; Humans; Isoxazoles; Kidney Calculi; Migraine Disorders; Pseudotumor Cerebri; Topiramate; Zonisamide | 2015 |
Tardive dyskinesia (syndrome): Current concept and modern approaches to its management.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; alpha-Tocopherol; Amantadine; Anticonvulsants; Antioxidants; Antipsychotic Agents; Clonazepam; Dopamine Agents; Drugs, Chinese Herbal; Fatty Acids, Omega-3; Ginkgo biloba; Humans; Isoleucine; Isoxazoles; Leucine; Levetiracetam; Melatonin; Movement Disorders; Nootropic Agents; Piracetam; Plant Extracts; Propranolol; Pyridoxine; Resveratrol; Stilbenes; Tetrabenazine; Valine; Vitamins; Zonisamide | 2015 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2015 |
Zonisamide for neuropathic pain in adults.
Topics: Adult; Analgesics; Anticonvulsants; Diabetic Neuropathies; Female; Humans; Isoxazoles; Male; Middle Aged; Neuralgia; Zonisamide | 2015 |
Current and emerging medications for overweight or obesity in people with comorbidities.
Topics: Anti-Obesity Agents; Bupropion; Cinnamates; Comorbidity; Cyclohexanes; Diabetes Mellitus; Dyslipidemias; Epoxy Compounds; Humans; Hypertension; Isoxazoles; Obesity; Overweight; Prediabetic State; Sesquiterpenes; Weight Loss; Zonisamide | 2015 |
Zonisamide in the management of epilepsy in the elderly.
Topics: Aged; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Zonisamide | 2015 |
The safety and long-term efficacy of zonisamide as adjunctive therapy for focal epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Combined Modality Therapy; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Young Adult; Zonisamide | 2015 |
[ZONISAMIDE: FIRST CHOICE AMONG THE FIRST-LINE ANTIEPILEPTIC DRUGS IN FOCAL EPILEPSY].
Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Approval; Drug Prescriptions; Electroencephalography; Encephalitis; Epilepsies, Partial; Humans; Hungary; Isoxazoles; Levetiracetam; Magnetic Resonance Imaging; Medication Adherence; Obesity; Phenytoin; Piracetam; Risk Assessment; Risk Factors; Seizures; Stroke; Weight Loss; Young Adult; Zonisamide | 2015 |
[New possibilities of monotherapy of symptomatic and cryptogenic partial epilepsy].
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Isoxazoles; Zonisamide | 2015 |
Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors.
Topics: Acetazolamide; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Antibodies, Monoclonal; Anticonvulsants; Antineoplastic Agents; Benzodiazepines; Carbonic Anhydrase Inhibitors; Celecoxib; Clinical Trials as Topic; Contraindications; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fructose; Humans; Isoxazoles; Methazolamide; Phenobarbital; Sulfanilamide; Sulfanilamides; Sulfonamides; Sulfonic Acids; Thiazines; Thiophenes; Topiramate; Zonisamide | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Combination Therapy with Zonisamide and Antiparkinson Drugs for Parkinson's Disease: A Meta-Analysis.
Topics: Antioxidants; Antiparkinson Agents; Drug Therapy, Combination; Humans; Isoxazoles; Parkinson Disease; Randomized Controlled Trials as Topic; Zonisamide | 2017 |
Anticonvulsant drugs for generalized tonic-clonic epilepsy.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Fructose; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Male; Nitriles; Piracetam; Pyridones; Randomized Controlled Trials as Topic; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
Zonisamide for essential tremor.
Topics: Anticonvulsants; Essential Tremor; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Zonisamide | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
[The role of zonisamide in the management of pediatric partial epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Zonisamide | 2016 |
[The role of zonisamide in the treatment of women with epilepsy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Zonisamide | 2016 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2018 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2020 |
93 trial(s) available for isoxazoles and zonisamide
| Article | Year |
|---|---|
The first open study of zonisamide, a novel anticonvulsant, shows efficacy in mania.
Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Female; Humans; Isoxazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenic Psychology; Zonisamide | 1994 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electroencephalography; Epilepsy; Female; Half-Life; Humans; Infant; Isoxazoles; Male; Phenytoin; Prospective Studies; Valproic Acid; Zonisamide | 1993 |
Zonisamide for add-on treatment of refractory partial epilepsy: a European double-blind trial.
Topics: Adolescent; Adult; Anticonvulsants; Double-Blind Method; Epilepsies, Partial; Europe; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 1993 |
Efficacy and safety of zonisamide: results of a multicenter study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 1993 |
The effects of antiepileptic drugs on cognition in normal volunteers.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition; Cross-Over Studies; Double-Blind Method; Humans; Isoxazoles; Phenytoin; Valproic Acid; Wechsler Scales; Zonisamide | 1996 |
Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures.
Topics: Anticonvulsants; Half-Life; Humans; Isoxazoles; Metabolic Clearance Rate; Seizures; Zonisamide | 1998 |
Zonisamide monotherapy in newly diagnosed infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Humans; Infant; Isoxazoles; Prospective Studies; Spasms, Infantile; Treatment Outcome; Zonisamide | 1997 |
Clinical pharmacology and therapeutic drug monitoring of zonisamide.
Topics: Animals; Anticonvulsants; Drug Interactions; Drug Monitoring; Humans; Isoxazoles; Zonisamide | 1998 |
Long-term effects of zonisamide in the treatment of epilepsy in children with intellectual disability.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Intellectual Disability; Isoxazoles; Male; Time Factors; Zonisamide | 1998 |
[Efficacy of zonisamide in West syndrome].
Topics: Anticonvulsants; Female; Humans; Infant; Isoxazoles; Male; Spasms, Infantile; Zonisamide | 1999 |
Treatment of infantile spasms with zonisamide.
Topics: Anticonvulsants; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Spasms, Infantile; Time Factors; Zonisamide | 1999 |
Predictive value of acetylcholine stimulation testing for oligohidrosis caused by zonisamide.
Topics: Acetylcholine; Anticonvulsants; Child; Child, Preschool; Cholinergic Agents; Epilepsy; False Positive Reactions; Female; Fever; Humans; Hypohidrosis; Isoxazoles; Male; Predictive Value of Tests; Prognosis; Sensitivity and Specificity; Sweating; Treatment Outcome; Zonisamide | 2000 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; Drug Industry; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Half-Life; Humans; Infant; Intestinal Absorption; Isoxazoles; Lamotrigine; Prospective Studies; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2000 |
Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Epilepsy, Complex Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Zonisamide | 2001 |
Zonisamide has beneficial effects on Parkinson's disease patients.
Topics: Aged; Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Dopamine; Dopamine Agonists; Drug Therapy, Combination; Female; Humans; Isoxazoles; Levodopa; Male; Middle Aged; Motor Activity; Parkinson Disease; Rats; Selegiline; Treatment Outcome; Zonisamide | 2001 |
Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Double-Blind Method; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Placebos; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
Long-term response to zonisamide in patients with West syndrome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Long-Term Care; Male; Prospective Studies; Spasms, Infantile; Zonisamide | 2002 |
Zonisamide for weight loss in obese adults: a randomized controlled trial.
Topics: Adult; Anti-Obesity Agents; Anticonvulsants; Body Mass Index; Caloric Restriction; Combined Modality Therapy; Diet, Reducing; Double-Blind Method; Female; Humans; Isoxazoles; Life Style; Male; Obesity; Patient Education as Topic; Risk Reduction Behavior; Single-Blind Method; Treatment Outcome; Weight Loss; Zonisamide | 2003 |
Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial.
Topics: Administration, Oral; Adult; Anticonvulsants; Body Weight; Bulimia; Female; Humans; Isoxazoles; Male; Severity of Illness Index; Treatment Outcome; Zonisamide | 2004 |
Zonisamide treatment for symptomatic infantile spasms.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Female; Humans; Infant; Isoxazoles; Male; Spasms, Infantile; Treatment Outcome; Zonisamide | 2004 |
Zonisamide monotherapy in a multi-group clinic.
Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Humans; Isoxazoles; Male; Patient Care Team; Zonisamide | 2004 |
Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Female; Health Status; Humans; Isoxazoles; Male; Middle Aged; Placebos; Treatment Outcome; Zonisamide | 2004 |
Safety of 25- and 50-mg capsules in the initiation of zonisamide therapy in patients with epilepsy: an uncontrolled, open-label study.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Isoxazoles; Male; United States; Zonisamide | 2004 |
Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Metabolic Clearance Rate; Middle Aged; Phenytoin; Zonisamide | 2004 |
Zonisamide monotherapy with once-daily dosing in children with cryptogenic localization-related epilepsies: clinical effects and pharmacokinetic studies.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2004 |
Effects of zonisamide monotherapy in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Electroencephalography; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Severity of Illness Index; Treatment Outcome; Tuberous Sclerosis; Zonisamide | 2004 |
Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Disability Evaluation; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Product Surveillance, Postmarketing; Severity of Illness Index; Time; Treatment Outcome; Zonisamide | 2004 |
Efficacy of zonisamide: our experience.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Product Surveillance, Postmarketing; Prospective Studies; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
Zonisamide clinical trials: European experience.
Topics: Adult; Anticonvulsants; Demography; Double-Blind Method; Epilepsy; Europe; Female; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Zonisamide | 2004 |
Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Biotransformation; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Epilepsy; Female; Humans; In Vitro Techniques; Isoenzymes; Isoxazoles; Kinetics; Male; Microsomes, Liver; Middle Aged; Tissue Distribution; Zonisamide | 2004 |
Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Epilepsies, Partial; Epilepsy, Complex Partial; Female; Headache; Humans; Isoxazoles; Male; Middle Aged; Pharyngitis; Placebos; Sleep Wake Disorders; Treatment Outcome; Zonisamide | 2005 |
A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Psychotropic Drugs; Treatment Outcome; Zonisamide | 2005 |
Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Anticonvulsants; Cross-Over Studies; Essential Tremor; Female; Humans; Isoxazoles; Male; Middle Aged; Pilot Projects; Propanolamines; Treatment Outcome; Zonisamide | 2005 |
Lack of clinically significant pharmacokinetic interactions between zonisamide and lamotrigine at steady state in patients with epilepsy.
Topics: Adult; Area Under Curve; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Lamotrigine; Liver; Male; Time Factors; Triazines; Zonisamide | 2005 |
Effect of zonisamide on the pharmacokinetics and pharmacodynamics of a combination ethinyl estradiol-norethindrone oral contraceptive in healthy women.
Topics: Adult; Anticonvulsants; Area Under Curve; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Cross-Over Studies; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Intestinal Absorption; Isoxazoles; Middle Aged; Norethindrone; Premenopause; Zonisamide | 2004 |
Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial.
Topics: Adult; Ambulatory Care; Anticonvulsants; Bipolar Disorder; Body Mass Index; Body Weight; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Patient Dropouts; Prospective Studies; Psychiatric Status Rating Scales; Psychotropic Drugs; Severity of Illness Index; Treatment Outcome; Zonisamide | 2005 |
Zonisamide as adjunctive therapy for refractory partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 2006 |
An open prospective study of zonisamide in acute bipolar depression.
Topics: Acute Disease; Adult; Anticonvulsants; Bipolar Disorder; Depressive Disorder; Female; Humans; Isoxazoles; Male; Middle Aged; Nausea; Outpatients; Prospective Studies; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome; Vomiting; Zonisamide | 2006 |
A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Electrophysiology; Equipment Design; Essential Tremor; Female; Humans; Isoxazoles; Male; Middle Aged; Severity of Illness Index; Treatment Outcome; Zonisamide | 2007 |
Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial.
Topics: Adult; Anticonvulsants; Body Mass Index; Bulimia; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Obesity; Weight Loss; Zonisamide | 2006 |
Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Motor Skills; Parkinson Disease; Single-Blind Method; Zonisamide | 2007 |
Prospective study of zonisamide therapy for refractory idiopathic epilepsy in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Isoxazoles; Prospective Studies; Treatment Outcome; Zonisamide | 2007 |
Long-term use of zonisamide in refractory childhood-onset epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Drug Evaluation; Electroencephalography; Female; Humans; Isoxazoles; Male; Myoclonic Epilepsy, Juvenile; Retrospective Studies; Time; Zonisamide | 2008 |
Is adjunctive open-label zonisamide effective for bipolar disorder?
Topics: Adolescent; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Zonisamide | 2008 |
Zonisamide and renal calculi in patients with epilepsy: how big an issue?
Topics: Adolescent; Adult; Anticonvulsants; Child; Double-Blind Method; Epilepsy; Female; Fructose; Humans; Isoxazoles; Kidney Calculi; Male; Middle Aged; Placebos; Product Surveillance, Postmarketing; Topiramate; Ultrasonography; Zonisamide | 2007 |
Current treatment of West syndrome in Japan.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Japan; Male; Practice Patterns, Physicians'; Spasms, Infantile; Surveys and Questionnaires; Valproic Acid; Vitamin B 6; Zonisamide | 2007 |
Zonisamide in patients with essential tremor and Parkinson's disease.
Topics: Anticonvulsants; Essential Tremor; Humans; Isoxazoles; Parkinson Disease; Zonisamide | 2007 |
Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.
Topics: Adult; Analysis of Variance; Anti-Obesity Agents; Bupropion; Drug Therapy, Combination; Female; Humans; Isoxazoles; Obesity; Treatment Outcome; Waist-Hip Ratio; Weight Loss; Zonisamide | 2007 |
[Anticonvulsant treatment with zonisamide added to topiramate. A preliminary treatment analysis in 19 patients].
Topics: Adult; Aged; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Isoxazoles; Male; Middle Aged; Pilot Projects; Topiramate; Treatment Outcome; Zonisamide | 2007 |
Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients.
Topics: Adolescent; Adult; Affect; Anticonvulsants; Cognition; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Male; Neuropsychological Tests; Prospective Studies; Zonisamide | 2008 |
Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Female; Humans; Isoxazoles; Male; Pancreatitis; Seizures; Severity of Illness Index; Sweating; Time Factors; Treatment Outcome; Vertigo; Zonisamide | 2009 |
Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Myoclonic Epilepsies, Progressive; Seizures; Zonisamide | 2008 |
Zonisamide decreases cortical excitability in patients with idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Electric Stimulation; Epilepsy, Generalized; Evoked Potentials, Motor; Female; Functional Laterality; Humans; Isoxazoles; Male; Motor Cortex; Neural Inhibition; Statistics, Nonparametric; Transcranial Magnetic Stimulation; Zonisamide | 2008 |
Secondary osteoporosis in long-term bedridden patients with cerebral palsy.
Topics: Absorptiometry, Photon; Adolescent; Alkaline Phosphatase; Anticonvulsants; Benzodiazepines; Biomarkers; Bone Density; Bone Density Conservation Agents; Cerebral Palsy; Child; Child, Preschool; Clobazam; Collagen Type I; Double-Blind Method; Drug Therapy, Combination; Etidronic Acid; Female; Follow-Up Studies; Humans; Hydroxycholecalciferols; Infant; Isoxazoles; Lumbar Vertebrae; Male; Osteoporosis; Peptides; Retrospective Studies; Risedronic Acid; Severity of Illness Index; Time Factors; Treatment Outcome; Zonisamide | 2008 |
Long-term safety and efficacy of zonisamide in patients with refractory partial-onset epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Resistance; Epilepsies, Partial; Humans; Isoxazoles; Longitudinal Studies; Safety; Time Factors; Treatment Outcome; Zonisamide | 2008 |
Effects of zonisamide on isolated head tremor.
Topics: Adrenergic beta-Antagonists; Aged; Anticonvulsants; Consciousness Disorders; Dose-Response Relationship, Drug; Essential Tremor; Female; Head Movements; Humans; Isoxazoles; Neck Muscles; Patient Compliance; Propranolol; Treatment Outcome; Zonisamide | 2008 |
Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Tolerance; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Italy; Magnetic Resonance Imaging; Male; Neurologic Examination; Statistics, Nonparametric; Young Adult; Zonisamide | 2009 |
Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy.
Topics: Adolescent; Anticonvulsants; Chemotherapy, Adjuvant; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Severity of Illness Index; Spasms, Infantile; Treatment Outcome; Zonisamide | 2010 |
The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers.
Topics: Adult; Alcohol Drinking; Anticonvulsants; Cross-Over Studies; Double-Blind Method; Ethanol; Female; Humans; Isoxazoles; Male; Middle Aged; Self Administration; Surveys and Questionnaires; Time Factors; Zonisamide | 2009 |
Bioequivalence of zonisamide orally dispersible tablet and immediate-release capsule formulations: results from two open-label, randomized-sequence, single-dose, two-period, two-treatment crossover studies in healthy male volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Area Under Curve; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Electrocardiography; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Zonisamide | 2009 |
Flexible dosing of adjunctive zonisamide in the treatment of adult partial-onset seizures: a non-comparative, open-label study (ZEUS).
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anticonvulsants; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; International Cooperation; Isoxazoles; Male; Middle Aged; Quality of Life; Severity of Illness Index; Treatment Outcome; Young Adult; Zonisamide | 2010 |
Open label trial of the tolerability and efficacy of zonisamide in the treatment of alcohol dependence.
Topics: Adult; Alcohol-Related Disorders; Analysis of Variance; Anticonvulsants; Drug Administration Schedule; Female; Humans; Intention to Treat Analysis; Isoxazoles; Male; Middle Aged; Patient Selection; Psychiatric Status Rating Scales; Surveys and Questionnaires; Treatment Outcome; Zonisamide | 2010 |
Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.
Topics: Adolescent; Adult; Aged; Alcoholism; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Pilot Projects; Treatment Outcome; Young Adult; Zonisamide | 2010 |
Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Isoxazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult; Zonisamide | 2010 |
Efficacy and safety of adjunctive zonisamide in adult patients with refractory partial-onset epilepsy: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Anticonvulsants; Double-Blind Method; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Placebos; Zonisamide | 2011 |
Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Humans; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2011 |
Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study.
Topics: Adolescent; Adult; Aged; Algorithms; Amantadine; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Metformin; Middle Aged; Olanzapine; Psychotic Disorders; Schizophrenia; Weight Gain; Zonisamide | 2012 |
Quality of life in patients with partial-onset seizures under adjunctive therapy with zonisamide: results from a prospective non-interventional surveillance study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsies, Partial; Female; Follow-Up Studies; Health Status; Humans; Isoxazoles; Male; Middle Aged; Prospective Studies; Quality of Life; Regression Analysis; Treatment Outcome; Young Adult; Zonisamide | 2011 |
Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Partial; Female; Humans; Isoxazoles; Korea; Male; Middle Aged; Seizures; Young Adult; Zonisamide | 2012 |
Effects of zonisamide on tardive dyskinesia: a preliminary open-label trial.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Female; Humans; Isoxazoles; Male; Movement Disorders; Treatment Outcome; Zonisamide | 2012 |
A randomized, placebo-controlled study of zonisamide to prevent olanzapine-associated weight gain.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Cognition Disorders; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Olanzapine; Regression Analysis; Schizophrenia; Treatment Outcome; Weight Gain; Young Adult; Zonisamide | 2012 |
Zonisamide for bipolar disorder, mania or mixed states: a randomized, double blind, placebo-controlled adjunctive trial.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Cyclothymic Disorder; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Quality of Life; Treatment Outcome; Zonisamide | 2011 |
Zonisamide monotherapy for idiopathic epilepsy in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Isoxazoles; Zonisamide | 2012 |
Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Young Adult; Zonisamide | 2012 |
Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial.
Topics: Adolescent; Adult; Aged; Antioxidants; Body Mass Index; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Obesity; Retrospective Studies; Treatment Outcome; Weight Loss; Young Adult; Zonisamide | 2012 |
The effect of zonisamide on antipsychotic-associated weight gain in patients with schizophrenia: a randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Antipsychotic Agents; Body Mass Index; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Obesity; Schizophrenia; Statistics, Nonparametric; Treatment Outcome; Waist Circumference; Weight Gain; Young Adult; Zonisamide | 2013 |
A randomized phase III trial of adjunctive zonisamide in pediatric patients with partial epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2013 |
Zonisamide in the treatment of bulimia nervosa: an open-label, pilot, prospective study.
Topics: Adult; Anticonvulsants; Body Mass Index; Bulimia Nervosa; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Isoxazoles; Male; Medication Adherence; Prospective Studies; Zonisamide | 2013 |
Adjunctive zonisamide therapy in the long-term treatment of children with partial epilepsy: results of an open-label extension study of a phase III, randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Anticonvulsants; Child; Double-Blind Method; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Time Factors; Treatment Outcome; Zonisamide | 2014 |
Zonisamide reduces obstructive sleep apnoea: a randomised placebo-controlled study.
Topics: Aged; Anthropometry; Body Mass Index; Body Weight; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Continuous Positive Airway Pressure; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Patient Compliance; Placebos; Polysomnography; Sleep; Sleep Apnea, Obstructive; Weight Loss; Zonisamide | 2014 |
Efficacy of zonisamide in migraineurs with nonresponse to topiramate.
Topics: Adult; Female; Fructose; Headache; Humans; Isoxazoles; Male; Middle Aged; Migraine Disorders; Paresthesia; Retrospective Studies; Topiramate; Treatment Outcome; Zonisamide | 2014 |
Long-term safety and efficacy of zonisamide versus carbamazepine monotherapy for treatment of partial seizures in adults with newly diagnosed epilepsy: results of a phase III, randomized, double-blind study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Double-Blind Method; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Young Adult; Zonisamide | 2014 |
Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.
Topics: Adult; Anti-Obesity Agents; Anticonvulsants; Body Mass Index; Cohort Studies; Combined Modality Therapy; Diet, Reducing; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Life Style; Male; Middle Aged; North Carolina; Obesity; Patient Compliance; Patient Education as Topic; Weight Gain; Zonisamide | 2014 |
Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders.
Topics: Adult; Aged; Alcohol Drinking; Alcohol-Related Disorders; Anticonvulsants; Cognition Disorders; Double-Blind Method; Female; Fructose; Humans; Isoxazoles; Levetiracetam; Male; Middle Aged; Neuropsychological Tests; Piracetam; Topiramate; Treatment Outcome; Young Adult; Zonisamide | 2015 |
Effects of adjunctive zonisamide treatment on weight and body mass index in children with partial epilepsy.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Weight Loss; Zonisamide | 2015 |
Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.
Topics: Aged; Anticonvulsants; Dopamine Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Japan; Male; Middle Aged; Parkinson Disease; Treatment Outcome; Zonisamide | 2015 |
[Zonisamid in additional treatment of pediatric partial epilepsy: a review of efficacy and safety in randomized double blind pacebo-controlled III phase study].
Topics: Adolescent; Anticonvulsants; Child; Double-Blind Method; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2015 |
Zonisamide Reduces Withdrawal Symptoms But Does Not Enhance Varenicline-Induced Smoking Cessation.
Topics: Adult; Humans; Isoxazoles; Nicotinic Agonists; Smoking Cessation; Substance Withdrawal Syndrome; Varenicline; Zonisamide | 2016 |
Brivaracetam in Unverricht-Lundborg disease (EPM1): Results from two randomized, double-blind, placebo-controlled studies.
Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fructose; Humans; Isoxazoles; Levetiracetam; Male; Middle Aged; Phenobarbital; Piracetam; Pyrrolidinones; Topiramate; Treatment Outcome; Unverricht-Lundborg Syndrome; Valproic Acid; Young Adult; Zonisamide | 2016 |
Population pharmacokinetics of zonisamide after oral administration in healthy Chinese volunteers.
Topics: Administration, Oral; Adult; Anticonvulsants; Asian People; China; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Isoxazoles; Linear Models; Male; Models, Biological; Nonlinear Dynamics; Young Adult; Zonisamide | 2016 |
A randomized, controlled, double-blind, crossover trial of zonisamide in myoclonus-dystonia.
Topics: Adolescent; Adult; Central Nervous System Agents; Cross-Over Studies; Disability Evaluation; Double-Blind Method; Dystonic Disorders; Female; Humans; Isoxazoles; Male; Sarcoglycans; Severity of Illness Index; Treatment Outcome; Young Adult; Zonisamide | 2016 |
Pharmacokinetics of zonisamide following rectal administration to healthy dogs.
Topics: Administration, Rectal; Animals; Anticonvulsants; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Dogs; Female; Half-Life; Isoxazoles; Male; Zonisamide | 2016 |
[Frequent episodic migraine and calcitonin gene-related peptide. Influence of treatment with topiramate and zonisamide on levels of the peptide].
Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Female; Fructose; Humans; Isoxazoles; Male; Middle Aged; Migraine Disorders; Topiramate; Young Adult; Zonisamide | 2017 |
391 other study(ies) available for isoxazoles and zonisamide
| Article | Year |
|---|---|
Pharmacokinetic interaction of zonisamide in rats. Effect of other antiepileptics on zonisamide.
Topics: Administration, Oral; Animals; Anticonvulsants; Blood Proteins; Diethylcarbamazine; Drug Interactions; Erythrocytes; Half-Life; Isoxazoles; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid; Zonisamide | 1992 |
Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Isoxazoles; Neurons; Rats; Rats, Inbred Strains; Zonisamide | 1992 |
Interaction of zonisamide with benzodiazepine and GABA receptors in rat brain.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; Isoxazoles; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Synaptic Membranes; Zonisamide | 1990 |
[3H]zonisamide binding in rat brain.
Topics: Animals; Anticonvulsants; Brain; Clonazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes; Zonisamide | 1990 |
Formation of reductive metabolite, 2-sulfamoylacetylphenol, from zonisamide in rat liver microsomes.
Topics: Anaerobiosis; Animals; Anticonvulsants; Carbon Monoxide; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoxazoles; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenols; Rats; Rats, Inbred Strains; Sulfonamides; Zonisamide | 1992 |
Effects of zonisamide on extracellular levels of monoamine and its metabolite, and on Ca2+ dependent dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Biogenic Monoamines; Calcium; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Hippocampus; Homovanillic Acid; Isoxazoles; Male; Rats; Rats, Wistar; Zonisamide | 1992 |
Pharmacokinetics of zonisamide; saturable distribution into human and rat erythrocytes and into rat brain.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Isoxazoles; Male; Rats; Rats, Wistar; Tissue Distribution; Zonisamide | 1992 |
Methodological requirements for clinical trials in refractory epilepsies--our experience with zonisamide.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Infant; Isoxazoles; Research Design; Zonisamide | 1992 |
[Zonisamide induced tremor--report of two cases].
Topics: Adult; Anticonvulsants; Electromyography; Female; Humans; Isoxazoles; Posture; Rest; Tremor; Zonisamide | 1992 |
Factors influencing serum concentration of zonisamide in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Zonisamide | 1992 |
[Effect of anticonvulsants upon experimental limbic seizure status and regional cerebral blood flow in the hippocampus].
Topics: Animals; Anticonvulsants; Cats; Diazepam; Electroencephalography; Hippocampus; Isoxazoles; Phenobarbital; Phenytoin; Regional Blood Flow; Status Epilepticus; Valproic Acid; Zonisamide | 1992 |
Reductive metabolism of the anticonvulsant agent zonisamide, a 1,2-benzisoxazole derivative.
Topics: Animals; Cytochrome P-450 Enzyme System; Enterobacteriaceae; Humans; Intestines; Isoxazoles; Liver; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Subcellular Fractions; Zonisamide | 1992 |
Monotherapy for childhood epilepsies with zonisamide.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Neurologic Examination; Zonisamide | 1991 |
Reversal of MRI lesion with relapse and remission of partial motor seizures in epilepsia partialis continua.
Topics: Adolescent; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Follow-Up Studies; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Phenytoin; Zonisamide | 1991 |
Determination of zonisamide (3-sulphamoylmethyl-1,2-benzisoxazole) in plasma at therapeutic concentrations by high-performance liquid chromatography.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Quality Control; Reproducibility of Results; Zonisamide | 1990 |
Competitive binding enzyme immunoassay for zonisamide, a new antiepileptic drug, with selected paired-enzyme labeled antigen and antibody.
Topics: Antibodies; Anticoagulants; Anticonvulsants; Antigens; beta-Galactosidase; Binding, Competitive; Chromatography, High Pressure Liquid; Cross Reactions; Galactosidases; Humans; Immune Sera; Immunoenzyme Techniques; Isoxazoles; Milk, Human; Oxazoles; Zonisamide | 1990 |
Zonisamide-induced mania.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lobe; Humans; Isoxazoles; Male; Oxazoles; Psychoses, Substance-Induced; Zonisamide | 1990 |
Effect of zonisamide on serum immunoglobulins.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Isoxazoles; Male; Middle Aged; Zonisamide | 1990 |
Effect of a novel anticonvulsant, zonisamide (AD-810, CI-912), in an experimental model of photosensitive epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Male; Photic Stimulation; Zonisamide | 1990 |
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.
Topics: Animals; Anticonvulsants; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Kindling, Neurologic; Male; Oxazoles; Phenytoin; Visual Cortex; Zonisamide | 1990 |
Zonisamide enhances slow sodium inactivation in Myxicola.
Topics: Animals; Anticonvulsants; Axons; Ion Channels; Isoxazoles; Membrane Potentials; Oxazoles; Polychaeta; Potassium; Sodium; Zonisamide | 1987 |
Zonisamide usage.
Topics: Epilepsies, Myoclonic; Humans; Isoxazoles; Kidney Calculi; Oxazoles; Zonisamide | 1989 |
Binding of sulfonamides to erythrocytes and their components.
Topics: Erythrocytes; Humans; In Vitro Techniques; Isoxazoles; Sulfonamides; Zonisamide | 1989 |
[3H]zonisamide binding in rat brain.
Topics: Animals; Anticonvulsants; Brain; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes; Zonisamide | 1988 |
Progressive myoclonus epilepsy treated with zonisamide.
Topics: Adult; Epilepsies, Myoclonic; Humans; Isoxazoles; Male; Oxazoles; Zonisamide | 1988 |
The antiepileptic effect of zonisamide on patients with refractory seizures and its side effect.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Evoked Potentials; Female; Humans; Isoxazoles; Male; Oxazoles; Zonisamide | 1988 |
Chronic toxicity of the anticonvulsant zonisamide in beagle dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Body Weight; Dogs; Eating; Electrocardiography; Isoxazoles; Liver; Oxazoles; Serum Albumin; Sex Factors; Time Factors; Zonisamide | 1988 |
The structure of (1,2-benzisoxazol-3-yl)methanesulfonamide: a novel antiepileptic drug.
Topics: Anticonvulsants; Hydrogen Bonding; Isoxazoles; Models, Molecular; Molecular Conformation; Oxazoles; X-Ray Diffraction; Zonisamide | 1988 |
Rapid identification of drug metabolites with tandem mass spectrometry.
Topics: Anticonvulsants; Humans; Isoxazoles; Mass Spectrometry; Pharmaceutical Preparations; Zonisamide | 1988 |
General pharmacology of the novel antiepileptic compound zonisamide. 1st communication: effects on central nervous system.
Topics: Animals; Anticonvulsants; Brain; Cats; Cerebrovascular Circulation; Cognition; Electroencephalography; Female; Hydrogen-Ion Concentration; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxazoles; Rats; Rats, Inbred Strains; Reflex; Species Specificity; Zonisamide | 1987 |
General pharmacology of the novel antiepileptic compound zonisamide. 2nd communication: effects on cardiovascular, visceral, renal and blood functions.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Coagulation; Cats; Digestive System; Dogs; Electrocardiography; Female; Guinea Pigs; Hemodynamics; Hemolysis; In Vitro Techniques; Isoxazoles; Kidney; Male; Mice; Oxazoles; Rats; Zonisamide | 1987 |
Simultaneous determination of Zonisamide and nine other anti-epileptic drugs and metabolites in serum. A comparison of microbore and conventional high-performance liquid chromatography.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Zonisamide | 1987 |
Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice.
Topics: Aging; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Zonisamide | 1987 |
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Humans; Isoxazoles; Kinetics; Male; Oxazoles; Phenytoin; Zonisamide | 1986 |
Blood-brain barrier transport of CI-912: single-passage equilibration of erythrocyte-borne drug.
Topics: Animals; Anticonvulsants; Biological Transport; Blood Proteins; Blood-Brain Barrier; Brain; Capillary Permeability; Erythrocytes; Humans; Isoxazoles; Oxazoles; Protein Binding; Rats; Zonisamide | 1985 |
Absorption, distribution and excretion of 3-(sulfamoyl[14C]methyl)-1,2-benziosoxazole (AD-810) in Rats, Dogs and Monkeys and of AD-810 in Men.
Topics: Animals; Autoradiography; Bile; Dogs; Erythrocytes; Female; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Macaca mulatta; Male; Middle Aged; Oxazoles; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Thiazines; Tissue Distribution; Zonisamide | 1983 |
Nonlinear pharmacokinetics of CI-912 in adult epileptic patients.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Pilot Projects; Zonisamide | 1984 |
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide | 1982 |
Pharmacokinetic studies of AD-810, a new antiepileptic compound. Phase I trials.
Topics: Adult; Anticonvulsants; Drug Evaluation; Electroencephalography; Erythrocytes; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Time Factors; Zonisamide | 1982 |
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Electroencephalographic profile.
Topics: Animals; Anticonvulsants; Arousal; Cats; Electroencephalography; Epilepsy; Female; Freezing; Hippocampus; Isoxazoles; Male; Oxazoles; Thalamus; Time Factors; Tungsten; Zonisamide | 1980 |
Effects of 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810) and some antiepileptics on the kindled seizures in the neocortex, hippocampus and amygdala in rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; Hippocampus; Isoxazoles; Male; Oxazoles; Rats; Seizures; Zonisamide | 1981 |
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile.
Topics: Animals; Anticonvulsants; Barbiturates; Carbonic Anhydrase Inhibitors; Dogs; Electroshock; Isoxazoles; Motor Activity; Oxazoles; Rabbits; Rats; Seizures; Sleep; Species Specificity; Time Factors; Zonisamide | 1980 |
Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Electroencephalography; Glucose; Isoxazoles; Kainic Acid; Limbic System; Rats; Rats, Wistar; Seizures; Status Epilepticus; Zonisamide | 1995 |
Effects of zonisamide on BAEP, SSEP and P300.
Topics: Adolescent; Adult; Anticonvulsants; Evoked Potentials; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Somatosensory; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 1995 |
[Effects of carbamazepine and zonisamide on dopaminergic system in rat striatum and hippocampus].
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Carbamazepine; Corpus Striatum; Dose-Response Relationship, Drug; Hippocampus; Isoxazoles; Male; Monoamine Oxidase; Rats; Rats, Wistar; Zonisamide | 1994 |
Simple and sensitive assay of zonisamide in human serum by high-performance liquid chromatography using a solid-phase extraction technique.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Spectrophotometry, Ultraviolet; Zonisamide | 1994 |
Regional distribution of 14C-zonisamide in rat brain.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Injections, Intravenous; Isoxazoles; Male; Rats; Rats, Wistar; Zonisamide | 1994 |
[Zonisamide monotherapy against absence attacks: report of two cases].
Topics: Child; Electroencephalography; Epilepsy, Absence; Female; Humans; Isoxazoles; Zonisamide | 1994 |
Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Brain Ischemia; Electroencephalography; Hippocampus; Hypoxia, Brain; Injections, Intraperitoneal; Isoxazoles; Necrosis; Rats; Rats, Wistar; Zonisamide | 1994 |
Evidence against a significant implication of carbonic anhydrase inhibitory activity of zonisamide in its anticonvulsive effects.
Topics: Animals; Anticonvulsants; Brain; Carbonic Anhydrase Inhibitors; Electroshock; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred Strains; Rats; Seizures; Zonisamide | 1994 |
Population analysis of the dose-dependent pharmacokinetics of zonisamide in epileptic patients.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Biological Availability; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studies; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Software; Zonisamide | 1994 |
Concentrations of zonisamide in serum, free fraction, mixed saliva and cerebrospinal fluid in epileptic children treated with monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Protein Binding; Saliva; Zonisamide | 1993 |
Two epileptics showing antiepileptic drug-induced psychoses.
Topics: Adolescent; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Humans; Isoxazoles; Male; Phenytoin; Psychoses, Substance-Induced; Zonisamide | 1993 |
Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vivo, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade of seizure spread.
Topics: Adenosine; Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Culture Techniques; Dopamine; Evoked Potentials; Hippocampus; Isoxazoles; Male; Rats; Rats, Wistar; Seizures; Serotonin; Synaptic Transmission; Zonisamide | 1993 |
Characterization of human liver microsomal cytochrome P450 involved in the reductive metabolism of zonisamide.
Topics: Anticonvulsants; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Isoxazoles; Microsomes, Liver; Oxidation-Reduction; Phenols; Sulfonamides; Zonisamide | 1993 |
Pharmacokinetic interaction of zonisamide in rats. Effect of zonisamide on other antiepileptics.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Drug Interactions; Erythrocytes; In Vitro Techniques; Isoxazoles; Male; Phenobarbital; Phenytoin; Protein Binding; Rats; Rats, Wistar; Valproic Acid; Zonisamide | 1993 |
Inhibitory effect of zonisamide on human carbonic anhydrase in vitro.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Erythrocytes; Humans; In Vitro Techniques; Isoenzymes; Isoxazoles; Zonisamide | 1993 |
[Age dependency of the serum concentration of zonisamide].
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Isoxazoles; Male; Middle Aged; Models, Biological; Zonisamide | 1993 |
[A case of behavior disorder with gait and sleep disturbances induced by zonisamide].
Topics: Anticonvulsants; Child; Female; Gait; Humans; Isoxazoles; Mental Disorders; Sleep Wake Disorders; Zonisamide | 1995 |
[The effect of zonisamide in West syndrome].
Topics: Anticonvulsants; Female; Humans; Infant; Isoxazoles; Male; Spasms, Infantile; Zonisamide | 1995 |
[Oligohidrosis caused by zonisamide].
Topics: Acetylcholine; Anticonvulsants; Child; Female; Hot Temperature; Humans; Hypohidrosis; Isoxazoles; Male; Zonisamide | 1996 |
Formation of 2-sulphamoylacetylphenol from zonisamide under aerobic conditions in rat liver microsomes.
Topics: Aerobiosis; Animals; Anticonvulsants; Biotransformation; Isoxazoles; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Oxygen; Phenols; Rats; Rats, Sprague-Dawley; Sulfonamides; Zonisamide | 1996 |
Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Anticonvulsants; Cricetinae; Cytosol; Electron Transport; Guinea Pigs; Isoxazoles; Liver; Male; Mesocricetus; Pyrimidines; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Zonisamide | 1996 |
Mechanisms of T-type calcium channel blockade by zonisamide.
Topics: Anticonvulsants; Calcium Channel Blockers; Cell Culture Techniques; Epilepsy; Humans; Isoxazoles; Neuroblastoma; Zonisamide | 1996 |
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Valproic Acid; Zonisamide | 1996 |
Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Female; Isoxazoles; Male; Mice; Mice, Mutant Strains; Phenobarbital; Seizures; Time Factors; Zonisamide | 1996 |
Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anencephaly; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Isoxazoles; Polypharmacy; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Risk Factors; Zonisamide | 1996 |
Effects of zonisamide on dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Enzyme Inhibitors; Extracellular Space; Hippocampus; Hydrazines; Isoxazoles; Male; Microdialysis; Monoamine Oxidase; Neostriatum; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase; Zonisamide | 1995 |
Pharmacokinetic study of zonisamide in patients undergoing brain surgery.
Topics: Adult; Aged; Anticonvulsants; Brain; Erythrocytes; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 1996 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Isoxazoles; Male; Phenobarbital; Time Factors; Valproic Acid; Zonisamide | 1997 |
Alcohol intake decreases brain Zonisamide concentration in inbred EL mice.
Topics: Animals; Anticonvulsants; Brain; Ethanol; Isoxazoles; Mice; Zonisamide | 1997 |
[Effects of carbamazepine and zonisamide on acetylcholine levels in rat striatum].
Topics: Acetylcholine; Acetylcholinesterase; Administration, Oral; Animals; Anticonvulsants; Brain; Butyrylcholinesterase; Carbamazepine; Corpus Striatum; Infusions, Parenteral; Isoxazoles; Male; Rats; Rats, Wistar; Zonisamide | 1997 |
IgA and IgG2 deficiency associated with zonisamide therapy: a case report.
Topics: Anticonvulsants; Epilepsy; Humans; IgA Deficiency; IgG Deficiency; Immunoglobulin A; Immunoglobulin G; Infant; Isoxazoles; Male; Zonisamide | 1997 |
The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Anti-Bacterial Agents; Anticonvulsants; Bacteria; Cecum; Cricetinae; Feces; Gastrointestinal Contents; Guinea Pigs; Intestinal Mucosa; Intestines; Isoxazoles; Male; Mesocricetus; Mice; Oxidation-Reduction; Phenols; Rabbits; Rats; Rats, Wistar; Species Specificity; Sulfonamides; Zonisamide | 1997 |
Heat stroke-like episode in a child caused by zonisamide.
Topics: Anticonvulsants; Biopsy; Child, Preschool; Epilepsy; Fever; Heat Stroke; Humans; Hypohidrosis; Isoxazoles; Male; Skin; Zonisamide | 1997 |
Utility of a rectal suppository containing the antiepileptic drug zonisamide.
Topics: Administration, Oral; Administration, Rectal; Animals; Anticonvulsants; Area Under Curve; Biological Availability; Electroshock; Injections, Intravenous; Isoxazoles; Male; Mice; Mice, Inbred ICR; Rats; Rats, Wistar; Suppositories; Zonisamide | 1997 |
Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of zonisamide.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Electrophoresis, Capillary; Fluorescence Polarization Immunoassay; Humans; Isoxazoles; Phenobarbital; Phenytoin; Zonisamide | 1997 |
Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Isoxazoles; Male; Maze Learning; Microdialysis; Neuroprotective Agents; Prosencephalon; Silver Staining; Zonisamide | 1997 |
Zonisamide for progressive myoclonus epilepsy: long-term observations in seven patients.
Topics: Adult; Anticonvulsants; Epilepsies, Myoclonic; Female; Humans; Isoxazoles; Male; Middle Aged; Time Factors; Zonisamide | 1998 |
[A case of cortical reflex myoclonus manifesting tremor].
Topics: Anticonvulsants; Cerebral Cortex; Clonazepam; Evoked Potentials, Somatosensory; Female; Humans; Isoxazoles; Magnetoencephalography; Middle Aged; Myoclonus; Reflex; Tremor; Valproic Acid; Zonisamide | 1997 |
Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse.
Topics: Animals; Anticonvulsants; Cell Count; Diet; Genetic Predisposition to Disease; Hippocampus; Isoxazoles; Mice; Mice, Mutant Strains; NADPH Dehydrogenase; Neurons; Seizures; Zinc; Zonisamide | 1998 |
Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Body Temperature; Carbamazepine; Cerebral Arterial Diseases; Cerebral Infarction; Humans; Ischemic Attack, Transient; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Reperfusion; Valproic Acid; Zonisamide | 1997 |
The anticonvulsant zonisamide scavenges free radicals.
Topics: Anticonvulsants; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Indicators and Reagents; Isoxazoles; Nitric Oxide; Reference Standards; Superoxides; Zonisamide | 1998 |
Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data.
Topics: Anticonvulsants; Cyclosporine; Cytochrome P-450 Enzyme System; Dihydroergotamine; Drug Interactions; Humans; In Vitro Techniques; Isoxazoles; Itraconazole; Ketoconazole; Metabolic Clearance Rate; Miconazole; Triazolam; Zonisamide | 1998 |
Interaction between Ca2+, K+, carbamazepine and zonisamide on hippocampal extracellular glutamate monitored with a microdialysis electrode.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Extracellular Space; Glutamic Acid; Hippocampus; Isoxazoles; Male; Microdialysis; Potassium; Rats; Rats, Wistar; Zonisamide | 1998 |
[Zonisamide:its placental transport, biological half-life in the newborn, and transport to mother's milk--a study of a case of an infant born of a mother who had been treated with zonisamide alone during pregnancy].
Topics: Adult; Anticonvulsants; Half-Life; Humans; Infant, Newborn; Isoxazoles; Male; Milk, Human; Placenta; Zonisamide | 1998 |
Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Follow-Up Studies; Hamartoma; Humans; Hypothalamic Diseases; Isoxazoles; Magnetic Resonance Imaging; Male; Radiosurgery; Tomography, X-Ray Computed; Valproic Acid; Zonisamide | 1998 |
[Experience in managing refractory status epilepticus caused by viral encephalitis under long-term anesthesia with barbiturate: a case report].
Topics: Adjuvants, Anesthesia; Adult; Anesthesia; Anticonvulsants; Encephalitis, Viral; Female; Herpes Simplex; Humans; Hypnotics and Sedatives; Isoxazoles; Respiration, Artificial; Secobarbital; Status Epilepticus; Time Factors; Zonisamide | 1998 |
Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Biogenic Amines; Blood Platelets; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Dopamine; Dopamine Uptake Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium; Male; Norepinephrine; p-Chloroamphetamine; Phenytoin; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Syndrome; Synaptosomes; Tetrodotoxin; Triazines; Valproic Acid; Zonisamide | 1998 |
Gynaecomastia in association with phenytoin and zonisamide in a patient having a CYP2C subfamily mutation.
Topics: Adult; Anticonvulsants; Epilepsies, Partial; Gynecomastia; Humans; Isoxazoles; Male; Metabolism, Inborn Errors; Phenytoin; Point Mutation; Zonisamide | 1998 |
Biphasic effects of zonisamide on serotonergic system in rat hippocampus.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Corpus Striatum; Extracellular Space; Hippocampus; Hydroxyindoleacetic Acid; Isoxazoles; Male; Osmolar Concentration; Rats; Rats, Wistar; Serotonin; Time Factors; Zonisamide | 1999 |
Effects of zonisamide on K+ and Ca2+ evoked release of monoamine as well as K+ evoked intracellular Ca2+ mobilization in rat hippocampus.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Calcium; Chromatography, High Pressure Liquid; Dopamine; Hippocampus; Image Processing, Computer-Assisted; Isoxazoles; Male; Microdialysis; Potassium; Rats; Rats, Wistar; Serotonin; Synaptic Transmission; Zonisamide | 1999 |
Monitoring of zonisamide in human breast milk and maternal plasma by solid-phase extraction HPLC method.
Topics: Adult; Anticonvulsants; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Isoxazoles; Milk, Human; Spectrophotometry, Ultraviolet; Zonisamide | 1999 |
The effects of exposure to cigarette smoke on the pharmacokinetics and pharmacodynamics of zonisamide in rats.
Topics: Animals; Anticonvulsants; Electroshock; Isoxazoles; Male; Rats; Rats, Wistar; Tobacco Smoke Pollution; Zonisamide | 1999 |
[Oligohidrosis caused by zonisamide: retrospective study].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Heat Stroke; Humans; Hypohidrosis; Infant; Isoxazoles; Male; Retrospective Studies; Surveys and Questionnaires; Zonisamide | 1999 |
[Three cases of hypoactivity and poor appetite with zonisamide-induced metabolic acidosis].
Topics: Acidosis; Adult; Anticonvulsants; Child; Feeding and Eating Disorders; Female; Humans; Hypokinesia; Isoxazoles; Male; Zonisamide | 2000 |
Psychotic episodes during zonisamide treatment.
Topics: Adult; Age Factors; Anticonvulsants; Case-Control Studies; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Obsessive-Compulsive Disorder; Psychoses, Substance-Induced; Remission Induction; Retrospective Studies; Treatment Outcome; Zonisamide | 2000 |
Running down phenomenon and acute interictal psychosis in medial temporal lobe epilepsy.
Topics: Adult; Age Factors; Anticonvulsants; Epilepsy, Temporal Lobe; Female; Humans; Isoxazoles; Male; Phenytoin; Psychoses, Substance-Induced; Recurrence; Sclerosis; Temporal Lobe; Zonisamide | 2000 |
Influence of exposure to new circumstances on pharmacokinetics of plasma drugs concentrations in rats.
Topics: Animals; Isoxazoles; Male; Nicorandil; Rats; Rats, Wistar; Stress, Psychological; Zonisamide | 2000 |
Two new drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Isoxazoles; Levetiracetam; Nootropic Agents; Oxcarbazepine; Piracetam; Sodium Channel Blockers; Zonisamide | 2000 |
Zonisamide - induced urinary lithiasis in patients with intractable epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Female; Humans; Hydronephrosis; Isoxazoles; Kidney Calculi; Male; Spasms, Infantile; Ultrasonography; Zonisamide | 2000 |
Zonisamide approved for partial seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; United States; United States Food and Drug Administration; Zonisamide | 2000 |
Zonisamide inhibits nitric oxide synthase activity induced by N-methyl-D-aspartate and buthionine sulfoximine in the rat hippocampus.
Topics: Animals; Anticonvulsants; Buthionine Sulfoximine; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hippocampus; Isoxazoles; N-Methylaspartate; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Zonisamide | 1999 |
Zonisamide reduces the increase in 8-hydroxy-2'-deoxyguanosine levels formed during iron-induced epileptogenesis in the brains of rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Chlorides; Deoxyguanosine; DNA Damage; Epilepsy; Ferric Compounds; Isoxazoles; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Zonisamide | 2000 |
Zonisamide (Zonegran) for epilepsy.
Topics: Adult; Anticonvulsants; Ataxia; Biological Availability; Calcium Channel Blockers; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Half-Life; Humans; Isoxazoles; Zonisamide | 2000 |
Successful zonisamide treatment for infants with hypsarrhythmia.
Topics: Anticonvulsants; Cerebral Cortex; Electroencephalography; Female; Humans; Infant; Isoxazoles; Male; Spasms, Infantile; Zonisamide | 2000 |
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Mutant Strains; Nitric Oxide; Phenytoin; Valproic Acid; Zonisamide | 2000 |
In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Hippocampus; Isoxazoles; Male; Microdialysis; Pyrrolidines; Radiation-Protective Agents; Rats; Rats, Wistar; Spin Labels; Zonisamide | 2000 |
Zonisamide treatment of early infantile epileptic encephalopathy.
Topics: Anticonvulsants; Electroencephalography; Epilepsy, Benign Neonatal; Female; Humans; Infant; Isoxazoles; Zonisamide | 2000 |
Renal tubular acidosis associated with zonisamide therapy.
Topics: Acidosis, Renal Tubular; Anticonvulsants; Blood Gas Analysis; Child; Electrolytes; Epilepsies, Partial; Humans; Isoxazoles; Male; Zonisamide | 2000 |
Urine stone formation during treatment with zonisamide.
Topics: Anticonvulsants; Child; Encephalitis, Viral; Epstein-Barr Virus Infections; Female; Hematuria; Herpesvirus 4, Human; Humans; Isoxazoles; Pyuria; Seizures; Urinary Calculi; Zonisamide | 2000 |
Effect of immobilization stress on anticonvulsant actions and pharmacokinetics of zonisamide in mice.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Electroshock; Isoxazoles; Male; Mice; Restraint, Physical; Spectrophotometry, Ultraviolet; Stress, Psychological; Zonisamide | 2001 |
High-performance liquid chromatographic assay of zonisamide in human plasma using a non-porous silica column.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Silicon Dioxide; Solvents; Zonisamide | 2001 |
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Phenobarbital; Receptors, N-Methyl-D-Aspartate; Zonisamide | 2001 |
Influences of caffeine to nitric oxide production and zonisamide concentration in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Brain; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Zonisamide | 2001 |
Extremely high drug-reductase activity based on aldehyde oxidase in monkey liver.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Guinea Pigs; Imipramine; In Vitro Techniques; Isoxazoles; Kinetics; Liver; Macaca fascicularis; Male; Mice; Pharmaceutical Preparations; Rabbits; Rats; Species Specificity; Zonisamide | 2001 |
Long-term observations of two siblings with Lafora disease treated with zonisamide.
Topics: Adult; Anticonvulsants; Fatal Outcome; Female; Follow-Up Studies; Humans; Isoxazoles; Lafora Disease; Male; Nuclear Family; Status Epilepticus; Zonisamide | 2001 |
Possible induction of systemic lupus erythematosus by zonisamide.
Topics: Antibodies, Antinuclear; Anticonvulsants; Child, Preschool; Epilepsy, Tonic-Clonic; Humans; Isoxazoles; Lupus Erythematosus, Systemic; Lymphocyte Activation; Male; Remission Induction; Time Factors; Zonisamide | 2001 |
Successful zonisamide treatment for infants with hypsarrhythmia.
Topics: Humans; Infant; Isoxazoles; Spasms, Infantile; Terminology as Topic; Zonisamide | 2001 |
Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures.
Topics: Animals; Anticonvulsants; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Injections, Intraventricular; Isoxazoles; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Seizures; Zonisamide | 2001 |
[A case of infantile epileptic encephalopathy with frequent focal motor status convulsivus: successful treatment with zonisamide].
Topics: Anticonvulsants; Electroencephalography; Epilepsy, Benign Neonatal; Epilepsy, Frontal Lobe; Female; Humans; Infant; Isoxazoles; Zonisamide | 2002 |
Unverricht-Lundborg disease with cystatin B gene abnormalities.
Topics: Adolescent; Alleles; Anticonvulsants; Blotting, Southern; Cystatin B; Cystatins; DNA Mutational Analysis; Electroencephalography; Erythropoietin; Gene Expression; Genetic Carrier Screening; Humans; Isoxazoles; Male; Peptides, Cyclic; Point Mutation; Primidone; Trinucleotide Repeat Expansion; Unverricht-Lundborg Syndrome; Zonisamide | 2002 |
Smoldering myeloma associated with zonisamide treatment.
Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy, Generalized; Humans; Immunoglobulin lambda-Chains; Intracranial Arteriovenous Malformations; Isoxazoles; Male; Multiple Myeloma; Myeloma Proteins; Subarachnoid Hemorrhage; Valproic Acid; Zonisamide | 2002 |
[A case of epilepsy after therapy with interferon-alpha-treated chronic hepatitis C].
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoxazoles; Male; Middle Aged; Zonisamide | 2002 |
Contrasting effects of zonisamide and acetazolamide on amygdaloid kindling in rats.
Topics: Acetazolamide; Amygdala; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsies, Partial; Isoxazoles; Kindling, Neurologic; Male; Rats; Rats, Wistar; Zonisamide | 2001 |
Pharmacokinetics of zonisamide in perinatal period.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Isoxazoles; Milk, Human; Pregnancy; Pregnancy Complications; Zonisamide | 2002 |
Interaction between carbamazepine, zonisamide and voltage-sensitive Ca2+ channel on acetylcholine release in rat frontal cortex.
Topics: Acetylcholine; Animals; Calcium Channels; Carbamazepine; Diffusion; Dose-Response Relationship, Drug; Drug Interactions; Frontal Lobe; Isoxazoles; Male; Microdialysis; Rats; Rats, Wistar; Zonisamide | 2002 |
Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes.
Topics: Adult; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epoxy Compounds; Erythromycin; Humans; Hydroxylation; In Vitro Techniques; Isoxazoles; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Nevirapine; Pharmaceutical Preparations; Phenols; Steroids; Sulfonamides; Triazolam; Zonisamide | 2002 |
Randomized controlled trial of zonisamide for the treatment of partial-onset seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Zonisamide | 2002 |
Clobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Circadian Rhythm; Clobazam; Clonazepam; Epilepsy; Epilepsy, Tonic-Clonic; Isoxazoles; Male; Rats; Rats, Mutant Strains; Zonisamide | 2002 |
The 'number needed to treat' with levetiracetam (LEV): comparison with the other new antiepileptic drugs (AEDs).
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
[Urolithiasis induced by combined ACTH and zonisamide treatment in a patient with startle induced epilepsy].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Kidney Calculi; Kidney Pelvis; Male; Reflex, Startle; Zonisamide | 2002 |
[Clinical features and treatment of refractory epilepsy in children].
Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Clonazepam; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Valproic Acid; Zonisamide | 2001 |
Selective mutism and obsessive compulsive disorders associated with zonisamide.
Topics: Adolescent; Anticonvulsants; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Mutism; Obsessive-Compulsive Disorder; Prospective Studies; Zonisamide | 2002 |
Protein-losing cytomegalovirus gastritis in a patient with Stevens-Johnson syndrome.
Topics: Adolescent; Anticonvulsants; Cytomegalovirus Infections; Female; Gastritis; Gastroscopy; Humans; Immunocompetence; Isoxazoles; Protein-Losing Enteropathies; Stevens-Johnson Syndrome; Zonisamide | 2002 |
Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Brain; Carbamazepine; Chlorpromazine; Diazepam; Fluvoxamine; Gene Expression; Haloperidol; Isoxazoles; Lithium; Male; Maprotiline; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Zonisamide | 2002 |
Zonisamide treatment of bipolar disorder: a case report.
Topics: Acute Disease; Anticonvulsants; Bipolar Disorder; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 2002 |
Zonisamide-induced restless legs syndrome.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Fatigue; Female; Humans; Isoxazoles; Restless Legs Syndrome; Treatment Outcome; Zonisamide | 2003 |
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Phenytoin; Prosencephalon; Seizures; Time Factors; Valproic Acid; Zonisamide | 2003 |
Effects of chronic administration of zonisamide, an antiepileptic drug, on bone mineral density and their prevention with alfacalcidol in growing rats.
Topics: Animals; Anticonvulsants; Bone Density; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hydroxycholecalciferols; Isoxazoles; Male; Rats; Rats, Wistar; Tibia; Zonisamide | 2003 |
[A five-year-old girl with epilepsy showing forced normalization due to zonisamide].
Topics: Anticonvulsants; Child Behavior Disorders; Child, Preschool; Communication Disorders; Electroencephalography; Epilepsy; Female; Fluvoxamine; Humans; Isoxazoles; Psychoses, Substance-Induced; Zonisamide | 2003 |
The effect of systemic zonisamide (Zonegran) on thermal hyperalgesia and mechanical allodynia in rats with an experimental mononeuropathy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Constriction; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Isoxazoles; Male; Motor Activity; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Zonisamide | 2003 |
Acute zonisamide overdose: a death revisited.
Topics: Adolescent; Anticonvulsants; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Diagnosis, Differential; Drug Overdose; Electrocardiography; Fatal Outcome; Female; Humans; Intracranial Hemorrhages; Isoxazoles; Suicide, Attempted; Tomography, X-Ray Computed; Zonisamide | 2003 |
Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures.
Topics: Amino Acid Transport System X-AG; Amygdala; Animals; Anticonvulsants; Blotting, Western; Carrier Proteins; Chlorides; Chronic Disease; Disease Models, Animal; Epilepsy; Ferric Compounds; Frontal Lobe; GABA Plasma Membrane Transport Proteins; Hippocampus; Isoxazoles; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Rats; Rats, Wistar; Zonisamide | 2003 |
[Effect of zonisamide on resting tremor resistant to antiparkinsonian medication].
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antiparkinson Agents; Humans; Isoxazoles; Levodopa; Male; Middle Aged; Parkinson Disease; Tremor; Zonisamide | 2003 |
Effect of antiepileptic drug monotherapy on crystalluria in children and young adults.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Retrospective Studies; Risk Factors; Sex Factors; Thiazines; Urinalysis; Urinary Calculi; Zonisamide | 2003 |
Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.
Topics: Administration, Oral; Adolescent; Adult; Aging; Anticonvulsants; Biological Availability; Body Surface Area; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Patient Selection; Phenytoin; Powders; Regression Analysis; Sex; Tablets; Zonisamide | 2003 |
Zonisamide-induced depression and mania in patients with epilepsy.
Topics: Adult; Bipolar Disorder; Depression; Epilepsy; Humans; Isoxazoles; Male; Polypharmacy; Treatment Outcome; Zonisamide | 2004 |
Successful use of zonisamide for central poststroke pain.
Topics: Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebral Infarction; Diabetes Complications; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Pain; Stroke; Zonisamide | 2004 |
Safety of newer antiepileptic drugs.
Topics: Anticonvulsants; Carbonic Anhydrase Inhibitors; Drug Labeling; Fructose; Humans; Isoxazoles; Topiramate; Zonisamide | 2004 |
Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Chronic Disease; Epilepsy; Humans; Isoxazoles; Male; Middle Aged; Pain; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Isoxazoles; Levodopa; Microdialysis; Oxidopamine; Parkinson Disease; Rats; Zonisamide | 2004 |
Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis.
Topics: Adult; Anticonvulsants; Anuria; Comorbidity; Drug Administration Schedule; Female; Hemodialysis Solutions; Humans; Isoxazoles; Kidney Failure, Chronic; Lupus Erythematosus, Systemic; Middle Aged; Protein Binding; Renal Dialysis; Seizures; Zonisamide | 2004 |
Acute treatment of bipolar depression with adjunctive zonisamide: a retrospective chart review.
Topics: Acute Disease; Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Retrospective Studies; Severity of Illness Index; Zonisamide | 2004 |
Overview of Japanese experience-controlled and uncontrolled trials.
Topics: Adolescent; Age Distribution; Anticonvulsants; Child; Child, Preschool; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Japan; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
Safety of zonisamide therapy: prospective follow-up survey.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Incidence; Infant; Isoxazoles; Male; Mental Disorders; Middle Aged; Product Surveillance, Postmarketing; Zonisamide | 2004 |
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Combinations; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Middle Aged; Phenobarbital; Phenytoin; Sex Factors; Valproic Acid; Zonisamide | 2004 |
Effects of zonisamide on the electroencephalogram of a patient with juvenile myoclonic epilepsy.
Topics: Adult; Anticonvulsants; Electroencephalography; Humans; Isoxazoles; Male; Myoclonic Epilepsy, Juvenile; Treatment Outcome; Zonisamide | 2004 |
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Isoxazoles; Male; Myoclonic Epilepsy, Juvenile; Retrospective Studies; Treatment Outcome; Valproic Acid; Zonisamide | 2004 |
A cautionary note when using zonisamide in youths: a case report of association with toxic epidermal necrolysis.
Topics: Adolescent; Anticonvulsants; Bipolar Disorder; Drug Hypersensitivity; Female; Humans; Isoxazoles; Stevens-Johnson Syndrome; Sulfonamides; Zonisamide | 2004 |
Zonisamide monotherapy for epilepsy in children and young adults.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Isoxazoles; Retrospective Studies; Treatment Outcome; United States; Zonisamide | 2005 |
Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats.
Topics: Animals; Bone Density; Calcium; Dentin; Drug Administration Schedule; Durapatite; Gingival Hyperplasia; Incisor; Injections, Subcutaneous; Isoxazoles; Male; Mandible; Microradiography; Phenytoin; Rats; Rats, Wistar; Zonisamide | 2004 |
Continued use of zonisamide following development of renal calculi.
Topics: Adult; Anticonvulsants; Calcium Citrate; Carbamazepine; Drug Therapy, Combination; Fluid Therapy; Humans; Isoxazoles; Kidney Calculi; Levetiracetam; Male; Oxcarbazepine; Piracetam; Recurrence; Ultrasonography; Ureteral Calculi; Zonisamide | 2005 |
Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center.
Topics: Adolescent; Anticonvulsants; Chemotherapy, Adjuvant; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electric Stimulation Therapy; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2005 |
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Topics: Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase V; Crystallography, X-Ray; Cytosol; Humans; Isoxazoles; Kinetics; Mitochondria; Models, Molecular; Protein Conformation; Zonisamide | 2005 |
Zonisamide for West syndrome: a comparison of clinical responses among different titration rate.
Topics: Anticonvulsants; Drug Administration Schedule; Humans; Infant; Isoxazoles; Spasms, Infantile; Zonisamide | 2005 |
Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Valproic Acid; Zonisamide | 2005 |
Use of zonisamide in pediatric patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Seizures; Zonisamide | 2005 |
Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism.
Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Dopamine; Drug Interactions; Electrochemistry; Fluorobenzenes; Isoxazoles; Lithium Chloride; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Time Factors; Zonisamide | 2005 |
[Effective and 15 years experience. New add-on option in epilepsy therapy]].
Topics: Anticonvulsants; Body Weight; Child; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Approval; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Isoxazoles; Patient Acceptance of Health Care; Zonisamide | 2005 |
[Control of side effects. Add on therapy demonstrates good tolerance].
Topics: Anticonvulsants; Body Weight; Controlled Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Patient Acceptance of Health Care; Treatment Outcome; Zonisamide | 2005 |
Efficacy of levetiracetam at 12 months in children classified by seizure type, cognitive status, and previous anticonvulsant drug use.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cognition; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Levetiracetam; Male; Piracetam; Retrospective Studies; Treatment Outcome; Zonisamide | 2005 |
Broad-spectrum efficacy of zonisamide at 12 months in children with intractable epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cognition; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Levetiracetam; Male; Piracetam; Retrospective Studies; Treatment Outcome; Zonisamide | 2005 |
Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil.
Topics: Animals; Anticonvulsants; Gerbillinae; Hippocampus; In Situ Hybridization; Isoxazoles; Neuropeptide Y; Seizures; Vigabatrin; Zonisamide | 2005 |
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide | 2005 |
Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors.
Topics: Animals; Anticonvulsants; Diffusion; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Male; Microdialysis; Neurotransmitter Agents; Potassium; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Zonisamide | 2005 |
In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.
Topics: Animals; Anticonvulsants; Electron Spin Resonance Spectroscopy; Hippocampus; Isoxazoles; Kainic Acid; Male; Microdialysis; Nitrogen Oxides; Oxidation-Reduction; Rats; Rats, Wistar; Seizures; Zonisamide | 2005 |
Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Free Radicals; Hippocampus; Isoxazoles; Kainic Acid; Male; Manganese Compounds; Mice; Oxides; Seizures; Zonisamide | 2005 |
Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting.
Topics: Anticonvulsants; Clonazepam; Diazepam; Female; Heart Arrest; Humans; Hypoxia, Brain; Isoxazoles; Levetiracetam; Middle Aged; Myoclonus; Phenobarbital; Piracetam; Valproic Acid; Zonisamide | 2006 |
Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Zonisamide | 2006 |
Determination of zonisamide by a coated monolithic column.
Topics: Anticonvulsants; Cations; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Isoxazoles; Molecular Structure; Reproducibility of Results; Silicon Dioxide; Solvents; Surface-Active Agents; Zonisamide | 2006 |
Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Infant; Isoxazoles; Zonisamide | 2006 |
Zonisamide prophylaxis in refractory pediatric headache.
Topics: Adolescent; Anticonvulsants; Child; Drug Resistance; Female; Humans; Isoxazoles; Male; Medical Records; Migraine Disorders; Retrospective Studies; Treatment Outcome; Zonisamide | 2006 |
Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Epilepsies, Partial; Epilepsy, Generalized; Female; Humans; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2006 |
Zonisamide eradicated paroxysmal headache with EEG abnormalities triggered by hypertensive encephalopathy due to purpura nephritic syndrome.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Female; Headache; Humans; Hypertensive Encephalopathy; Isoxazoles; Magnetic Resonance Imaging; Nephritis; Skin Diseases; Zonisamide | 2006 |
[An animal model of antiepileptic-induced osteoporosis in rats].
Topics: Animals; Anticonvulsants; Bone Density; Disease Models, Animal; Isoxazoles; Osteoporosis; Phenytoin; Rats; Zonisamide | 2006 |
Zonisamide-induced mania in an essential tremor patient.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Essential Tremor; Female; Humans; Isoxazoles; Zonisamide | 2006 |
Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Epilepsy; Fluorescent Antibody Technique; Isoxazoles; Male; Mice; Zonisamide | 2007 |
Zonisamide for migraine prophylaxis in refractory patients.
Topics: Adult; Anticonvulsants; Drug Resistance; Female; Humans; Isoxazoles; Male; Middle Aged; Migraine Disorders; Retrospective Studies; Treatment Outcome; Zonisamide | 2006 |
[New medications; zonisamide].
Topics: Anticonvulsants; Calcium Channels; Epilepsies, Partial; Humans; Isoxazoles; Sodium Channels; Synaptic Transmission; Treatment Outcome; Zonisamide | 2006 |
A long-term follow-up of zonisamide monotherapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Longitudinal Studies; Male; Medical Records; Statistics, Nonparametric; Treatment Outcome; Zonisamide | 2006 |
Restoration of bile ducts in drug-induced vanishing bile duct syndrome due to zonisamide.
Topics: Adult; Anticonvulsants; Bile Duct Diseases; Bile Ducts, Intrahepatic; Cholestasis, Intrahepatic; Humans; Isoxazoles; Male; Regeneration; Treatment Outcome; Withholding Treatment; Zonisamide | 2006 |
A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Isoxazoles; Mobius Syndrome; Pregnancy; Pregnancy Complications; Vocal Cord Paralysis; Zonisamide | 2007 |
Zonisamide or levetiracetam for adults with cyclic vomiting syndrome: a case series.
Topics: Adult; Aged; Anticonvulsants; Antidepressive Agents, Tricyclic; Female; Humans; Interviews as Topic; Isoxazoles; Levetiracetam; Male; Middle Aged; Periodicity; Piracetam; Remission Induction; Retrospective Studies; Syndrome; Treatment Outcome; Vomiting; Zonisamide | 2007 |
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Isoxazoles; Lung Diseases, Interstitial; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Spasms, Infantile; Valproic Acid; Zonisamide | 2007 |
Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Lamotrigine; Plasma; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Triazines; Zonisamide | 2007 |
Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Topics: Action Potentials; Anticonvulsants; Calcium; Calcium Channels, L-Type; Cell Differentiation; Cell Line; Electrophysiology; Hippocampus; Humans; Isoxazoles; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Models, Statistical; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Zonisamide | 2007 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 8; Clone Cells; Cocarcinogenesis; Drug Therapy, Combination; Epilepsy, Absence; Female; Humans; Isoxazoles; Lamotrigine; Leukemia, Myeloid; Levetiracetam; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Phenobarbital; Piracetam; Translocation, Genetic; Triazines; Valproic Acid; Zonisamide | 2008 |
Erratum to "Safety of zonisamide therapy: prospective follow-up survey.".
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Incidence; Infant; Isoxazoles; Male; Mental Disorders; Middle Aged; Product Surveillance, Postmarketing; Zonisamide | 2007 |
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Monitoring; Epilepsy; Female; Gene Frequency; Genetics, Population; Heterozygote; Homozygote; Humans; Immunoassay; Isoxazoles; Japan; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Polymorphism, Genetic; Regression Analysis; Valproic Acid; Zonisamide | 2007 |
Sclerodermoid graft-versus-host disease-like lesions occurring after drug-induced hypersensitivity syndrome.
Topics: Anticonvulsants; Drug Hypersensitivity; Female; Humans; Isoxazoles; Middle Aged; Scleroderma, Localized; Zonisamide | 2007 |
Psychosis following initiation of zonisamide.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Middle Aged; Psychoses, Substance-Induced; Zonisamide | 2007 |
Zonisamide as treatment for seizures.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Isoxazoles; Seizures; Zonisamide | 2007 |
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Fructose; Humans; Isoxazoles; Mitochondria; Models, Molecular; Molecular Sequence Data; Sequence Homology, Amino Acid; Topiramate; Zonisamide | 2007 |
Zonisamide decreases ethanol intake in rats and mice.
Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Fructose; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Sucrose; Topiramate; Zonisamide | 2007 |
Restless legs syndrome induced by zonisamide.
Topics: Antioxidants; Female; Humans; Hypertension; Isoxazoles; Middle Aged; Restless Legs Syndrome; Zonisamide | 2007 |
Adjunctive zonisamide for treatment refractory anxiety.
Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Cohort Studies; Female; Humans; Isoxazoles; Male; Middle Aged; Pilot Projects; Recurrence; Severity of Illness Index; Treatment Outcome; Zonisamide | 2007 |
Potential efficacy of zonisamide in refractory juvenile myoclonic epilepsy: retrospective evidence from an Irish compassionate-use case series.
Topics: Adolescent; Adult; Anticonvulsants; Empathy; Female; Humans; Ireland; Isoxazoles; Myoclonic Epilepsy, Juvenile; Recurrence; Retrospective Studies; Treatment Outcome; Zonisamide | 2007 |
Effects of zonisamide on experimental tremors in rats.
Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Cholinesterase Inhibitors; Harmaline; Isoxazoles; Male; Muscarinic Agonists; Oxotremorine; Rats; Rats, Sprague-Dawley; Tacrine; Tremor; Zonisamide | 2008 |
Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Cattle; Chromatography, High Pressure Liquid; Drug Monitoring; Ethosuximide; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Primidone; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Solutions; Specimen Handling; Spectrophotometry, Ultraviolet; Temperature; Triazines; Valproic Acid; Zonisamide | 2007 |
Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoxazoles; Neural Inhibition; Neurons; Serotonin; Theophylline; Zonisamide | 2007 |
The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system.
Topics: Analgesics; Animals; Biogenic Monoamines; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Ligation; Male; Mice; Neuralgia; Pain Measurement; Physical Stimulation; Sciatic Nerve; Sciatic Neuropathy; Zonisamide | 2007 |
Neuroleptic malignant syndrome-like state in an epileptic patient with organic brain comorbidity treated with zonisamide and carbamazepine.
Topics: Adult; Anticonvulsants; Brain Diseases; Carbamazepine; Comorbidity; Epilepsy; Humans; Isoxazoles; Male; Neuroleptic Malignant Syndrome; Zonisamide | 2007 |
Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Korea; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2008 |
Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nitrogen; Oxcarbazepine; Phosphorus; Piracetam; Reproducibility of Results; Triazines; Ultraviolet Rays; Zonisamide | 2007 |
Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation.
Topics: alpha-Synuclein; Animals; Antioxidants; Biopterins; Cell-Free System; Cells, Cultured; Cytosol; Dopamine; Isoxazoles; Ketanserin; Lewy Bodies; Melanins; Mice; Neurons; Oxidative Stress; Parkinson Disease; Quinones; Ubiquitin-Protein Ligases; Zonisamide | 2008 |
Toxic epidermal necrolysis due to zonisamide associated with reactivation of human herpesvirus 6.
Topics: Aged; Anticonvulsants; DNA, Viral; Herpesvirus 6, Human; Humans; Immunoglobulin G; Isoxazoles; Male; Stevens-Johnson Syndrome; Virus Activation; Zonisamide | 2008 |
Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.
Topics: Animals; Anticonvulsants; Appetite Regulation; Benzodiazepines; Biomarkers; Body Weight; Diabetes Mellitus; Female; Hyperglycemia; Hyperphagia; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Isoxazoles; Neurons; Neuropeptides; Nucleus Accumbens; Obesity; Olanzapine; Orexins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Weight Gain; Zonisamide | 2008 |
Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate.
Topics: Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Erythrocytes; Fructose; Humans; Isoxazoles; Sulfonamides; Topiramate; Zonisamide | 2008 |
Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Data Interpretation, Statistical; Electrophysiology; Epilepsy; Female; Guinea Pigs; Hippocampus; Hydrogen-Ion Concentration; In Vitro Techniques; Isoxazoles; Membrane Potentials; Microelectrodes; Neurons; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Theophylline; Zonisamide | 2008 |
Pharmacokinetics and toxicity of zonisamide in cats.
Topics: Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Biological Availability; Cat Diseases; Cats; Dose-Response Relationship, Drug; Female; Isoxazoles; Male; Metabolic Clearance Rate; Zonisamide | 2008 |
Does drug-induced hypersensitivity syndrome elicit bullous pemphigoid?
Topics: Aged; Anti-Bacterial Agents; Carbamazepine; Drug Hypersensitivity; Female; Humans; Immunosuppressive Agents; Isoxazoles; Minocycline; Pemphigoid, Bullous; Pharyngitis; Syndrome; Time Factors; Treatment Outcome; Trigeminal Neuralgia; Zonisamide | 2008 |
Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures.
Topics: Anticonvulsants; Biological Transport; Child; DNA Mutational Analysis; Erythrocytes; Female; Glucose; Glucose Transporter Type 1; Humans; Isoxazoles; Male; Methylgalactosides; Seizures; Zonisamide | 2008 |
Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs.
Topics: Animals; Anticonvulsants; Area Under Curve; Biological Availability; Dogs; Drug Interactions; Female; Half-Life; Isoxazoles; Metabolic Clearance Rate; Phenobarbital; Zonisamide | 2008 |
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mice; Motor Activity; Rats; Seizures; Sulfonamides; Urea; Valproic Acid; Zonisamide | 2008 |
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Inflammation; Isoxazoles; Male; Mice; Pain; Streptozocin; Zonisamide | 2008 |
Treatment emergent mania responding to valproate in a Chinese female adolescent population with eating disorders: a case series.
Topics: Adolescent; Anorexia Nervosa; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Bulimia Nervosa; Feeding and Eating Disorders; Female; Humans; Isoxazoles; Male; Phenytoin; Risk Factors; Sex Characteristics; Singapore; Valproic Acid; Young Adult; Zonisamide | 2008 |
Zonisamide concentrations during pregnancy.
Topics: Adult; Anticonvulsants; Female; Humans; Isoxazoles; Myoclonic Epilepsy, Juvenile; Pregnancy; Pregnancy Complications; Seizures; Zonisamide | 2008 |
Case-control analysis of ambulance, emergency room, or inpatient hospital events for epilepsy and antiepileptic drug formulation changes.
Topics: Adult; Ambulances; Anticonvulsants; Case-Control Studies; Cost Savings; Drug Costs; Drugs, Generic; Emergency Medical Services; Emergency Service, Hospital; Epilepsies, Partial; Epilepsy, Generalized; Female; Humans; Isoxazoles; Male; Medicaid; Middle Aged; Odds Ratio; Patient Admission; Retrospective Studies; Therapeutic Equivalency; Treatment Outcome; United States; Young Adult; Zonisamide | 2009 |
[Zonisamide as add-on treatment for focal epilepsies. An outcome analysis of 74 patients].
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Young Adult; Zonisamide | 2008 |
Predicting possible zonisamide hypersensitivity syndrome.
Topics: Adult; Age Factors; Aged; Animals; Anticonvulsants; Cell Survival; Diagnostic Techniques and Procedures; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Exanthema; Female; Humans; Isoxazoles; Lymphocytes; Male; Mice; Microsomes, Liver; Middle Aged; Sensitivity and Specificity; Sex Factors; Sulfamethoxazole; Young Adult; Zonisamide | 2008 |
Population estimation regarding the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Body Weight; Child; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Isoxazoles; Japan; Male; Models, Statistical; Polymorphism, Genetic; Population; Sex Characteristics; Young Adult; Zonisamide | 2008 |
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Isoxazoles; Jaw; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tacrine; Tremor; Zonisamide | 2009 |
Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.
Topics: Animals; Anticonvulsants; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Epilepsy; Hippocampus; Humans; Isoxazoles; Mammals; Protein Isoforms; Structure-Activity Relationship; Substrate Specificity; Zonisamide | 2008 |
Treatment of seizures in a patient with Batten's disease.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Isoxazoles; Levetiracetam; Male; Neuronal Ceroid-Lipofuscinoses; Piracetam; Quality of Life; Zonisamide | 2008 |
Disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Biological Availability; Dogs; Drug-Related Side Effects and Adverse Reactions; Female; Half-Life; Injections, Intravenous; Isoxazoles; Linear Models; Male; Metabolic Clearance Rate; Protein Binding; Thyroid Hormones; Zonisamide | 2008 |
The impact of zonisamide on weight. A clinical study in 103 patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Body Mass Index; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Time Factors; Young Adult; Zonisamide | 2009 |
Zonisamide for essential tremor: an evaluator-blinded study.
Topics: Aged; Anticonvulsants; Drug Administration Schedule; Essential Tremor; Female; Humans; Isoxazoles; Male; Severity of Illness Index; Single-Blind Method; Upper Extremity; Zonisamide | 2009 |
Zonisamide block of cloned human T-type voltage-gated calcium channels.
Topics: Anticonvulsants; Biophysical Phenomena; Biophysics; Calcium Channels, T-Type; Caveolin 3; Cell Line, Transformed; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Isoxazoles; Membrane Potentials; Patch-Clamp Techniques; Transfection; Zonisamide | 2009 |
[New antiepileptic drugs].
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Pregabalin; Triazines; Zonisamide | 2009 |
A novel anti-Parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anticonvulsants; Antiparkinson Agents; Astrocytes; Corpus Striatum; Dopamine; Glial Fibrillary Acidic Protein; Homovanillic Acid; Isoxazoles; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase; Zonisamide | 2009 |
Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Spain; Treatment Outcome; Young Adult; Zonisamide | 2009 |
Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Extracellular Fluid; Fructose; Hippocampus; Isoxazoles; Male; Movement; Neurotransmitter Agents; Phenytoin; Rats; Rats, Sprague-Dawley; Topiramate; Zonisamide | 2009 |
Simultaneous estimation of four proton pump inhibitors--lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, High Pressure Liquid; Drug Stability; Humans; Isoxazoles; Lansoprazole; Male; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Rabeprazole; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Zonisamide | 2009 |
Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Biogenic Amines; Brain Chemistry; Callithrix; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Homovanillic Acid; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Selegiline; Zonisamide | 2009 |
Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors.
Topics: Animals; Anticonvulsants; Calcium Channels; Dose-Response Relationship, Drug; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Inositol 1,4,5-Trisphosphate Receptors; Isoxazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Zonisamide | 2009 |
Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Isoxazoles; Male; Neural Pathways; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Opioid, delta; Substantia Nigra; Subthalamic Nucleus; Zonisamide | 2009 |
Stability of zonisamide in extemporaneously compounded oral suspensions.
Topics: Administration, Oral; Anticonvulsants; Chromatography, High Pressure Liquid; Drug Compounding; Drug Stability; Drug Storage; Isoxazoles; Methylcellulose; Refrigeration; Sucrose; Suspensions; Temperature; Time Factors; Zonisamide | 2009 |
Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on.
Topics: Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Epilepsy; Erectile Dysfunction; Humans; Isoxazoles; Male; Seizures; Zonisamide | 2011 |
Possible mechanism for zonisamide-induced hyperammonemia in a child with citrullinemia type 1.
Topics: Anticonvulsants; Child; Citrullinemia; Humans; Hyperammonemia; Isoxazoles; Male; Seizures; Zonisamide | 2009 |
Zonisamide: in Parkinson's disease.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Epilepsy; Humans; Isoxazoles; Parkinson Disease; Zonisamide | 2009 |
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Fructose; Humans; Isoxazoles; Middle Aged; Remission Induction; Sleep Stages; Temporal Lobe; Theta Rhythm; Topiramate; Valproic Acid; Zonisamide | 2009 |
Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Neurologic Examination; Zonisamide | 2009 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Generalized; Frontal Lobe; Hippocampus; Isoxazoles; Kindling, Neurologic; Male; Olfactory Bulb; Rats; Rats, Wistar; Seizures; Valproic Acid; Zonisamide | 2010 |
Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction.
Topics: Action Potentials; Animals; Antioxidants; Bicuculline; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; Glucose; Glutamic Acid; In Vitro Techniques; Isoxazoles; Male; Neurons; Nitro Compounds; Propionates; Rats; Rats, Wistar; Rotenone; Uncoupling Agents; Zonisamide | 2010 |
Effectiveness and tolerability of zonisamide in children with epilepsy: a retrospective review.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Evaluation; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Young Adult; Zonisamide | 2010 |
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glutathione; Isoxazoles; Male; Mass Spectrometry; Mice; Monoamine Oxidase; MPTP Poisoning; Regression, Psychology; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Triazines; Triazoles; Ultraviolet Rays; Zonisamide | 2010 |
Zonisamide in Parkinson's disease: profile report.
Topics: Antioxidants; Humans; Isoxazoles; Parkinson Disease; Treatment Outcome; Zonisamide | 2010 |
Zonisamide in West syndrome: an open label study.
Topics: Age of Onset; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Spasms, Infantile; Zonisamide | 2009 |
Zonisamide-related erectile dysfunction.
Topics: Anticonvulsants; Brain Neoplasms; Epilepsy; Humans; Impotence, Vasculogenic; Isoxazoles; Male; Nitric Oxide Synthase; Zonisamide | 2011 |
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Anticonvulsants; Drug Hypersensitivity; Epilepsy; Exanthema; Humans; Isoxazoles; Male; Patch Tests; Treatment Outcome; Zonisamide | 2010 |
A prospective audit of adjunctive zonisamide in an everyday clinical setting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Chemotherapy, Adjuvant; Electroencephalography; Epilepsy; Female; Humans; Isoxazoles; Male; Medical Audit; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult; Zonisamide | 2010 |
Neuroprotective effects of zonisamide target astrocyte.
Topics: Animals; Antiparkinson Agents; Astrocytes; Basal Ganglia; Carbidopa; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Glutathione; Isoxazoles; Male; Mice; Mice, Inbred ICR; Nerve Growth Factors; Neuroprotective Agents; Oxidopamine; Parkinson Disease; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
Infantile spasms: who are the ideal surgical candidates?
Topics: Anticonvulsants; Brain; Electroencephalography; Humans; Infant; Isoxazoles; Magnetic Resonance Imaging; Patient Selection; Positron-Emission Tomography; Spasms, Infantile; Vigabatrin; Zonisamide | 2010 |
Administration of zonisamide in three cases of dementia with Lewy bodies.
Topics: Aged; Antiparkinson Agents; Caregivers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Lewy Body Disease; Middle Aged; Parkinsonian Disorders; Zonisamide | 2010 |
Successful treatment of extrapyramidal and psychotic symptoms with zonisamide in a patient with dementia with Lewy bodies.
Topics: Aged; Basal Ganglia Diseases; Female; Humans; Isoxazoles; Lewy Body Disease; Psychotic Disorders; Treatment Outcome; Zonisamide | 2010 |
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopamine; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Substantia Nigra; Treatment Outcome; Zonisamide | 2010 |
Steady-state pharmacokinetics of zonisamide in plasma, whole blood, and erythrocytes in dogs.
Topics: Animals; Anticonvulsants; Dogs; Dose-Response Relationship, Drug; Female; Isoxazoles; Zonisamide | 2010 |
Zonisamide: aspects in neuroprotection.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Humans; Isoxazoles; Neurons; Neuroprotective Agents; Parkinson Disease; Zonisamide | 2010 |
Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy.
Topics: Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Epilepsy; Female; Fructose; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Risk Factors; Topiramate; Urolithiasis; Zonisamide | 2010 |
Zonisamide: a new drug for Parkinson's disease.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Clinical Trials as Topic; Half-Life; Humans; Isoxazoles; Neuroprotective Agents; Parkinson Disease; Tissue Distribution; Zonisamide | 2010 |
Zonisamide in managing impulse control disorders in Parkinson's disease.
Topics: Aged; Antioxidants; Disruptive, Impulse Control, and Conduct Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Retrospective Studies; Zonisamide | 2010 |
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclopropanes; Disease Models, Animal; Essential Tremor; Estranes; Ethosuximide; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Naphthalenes; Nitriles; Receptors, GABA-A; Zonisamide | 2010 |
Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antioxidants; Apoptosis; Caspases; Cell Differentiation; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Isoxazoles; Neuroblastoma; Neurotoxins; Staurosporine; Superoxide Dismutase; Up-Regulation; Zonisamide | 2010 |
Zonisamide ameliorates symptoms of secondary paroxysmal dystonia.
Topics: Adolescent; Antioxidants; Child; Dystonic Disorders; Female; Hemochromatosis; Humans; Isoxazoles; Male; Pyruvate Dehydrogenase Complex Deficiency Disease; Zonisamide | 2010 |
Zonisamide discontinuation due to psychiatric and cognitive adverse events: a case-control study.
Topics: Adult; Anticonvulsants; Case-Control Studies; Cognition Disorders; Epilepsy; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Retrospective Studies; Risk Factors; Young Adult; Zonisamide | 2010 |
[Psychosis due to zonisamide: an infrequent case].
Topics: Aged; Anticonvulsants; Humans; Isoxazoles; Psychotic Disorders; Zonisamide | 2010 |
A pilot open-label trial of zonisamide in Unverricht-Lundborg disease.
Topics: Adult; Aged; Anticonvulsants; Female; Humans; Isoxazoles; Male; Middle Aged; Myoclonus; Pilot Projects; Treatment Outcome; Unverricht-Lundborg Syndrome; Zonisamide | 2011 |
Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Incidence; Isoxazoles; Male; Rats; Rats, Wistar; Reaction Time; Seizures; Zonisamide | 2010 |
Zonisamide attenuates MPTP neurotoxicity in marmosets.
Topics: Animals; Antiparkinson Agents; Callithrix; Corpus Striatum; Dopamine; Female; Humans; Isoxazoles; Male; MPTP Poisoning; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopamine; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Substantia Nigra; Treatment Outcome; Zonisamide | 2010 |
A case of SUNCT syndrome responsive to zonisamide.
Topics: Adult; Humans; Isoxazoles; Male; SUNCT Syndrome; Zonisamide | 2011 |
Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
Topics: Acrolein; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Glutathione; Humans; In Vitro Techniques; Isoxazoles; Leflunomide; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Zonisamide | 2011 |
Efficacy of zonisamide in a case of Parkinson's disease with intractable resting and re-emergent tremor.
Topics: Aged; Antiparkinson Agents; Electromyography; Female; Humans; Isoxazoles; Parkinson Disease; Rest; Secondary Prevention; Tremor; Zonisamide | 2011 |
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex.
Topics: Animals; Anticonvulsants; Binding Sites; Crystallography, X-Ray; Humans; Isoxazoles; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Conformation; Rats; Zonisamide | 2011 |
Prolapse gastropathy.
Topics: Anticonvulsants; Child; Humans; Isoxazoles; Male; Prolapse; Radiography; Stomach Diseases; Vomiting; Zonisamide | 2011 |
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.
Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Aged; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Epilepsy; Female; Fructose; Genome-Wide Association Study; Humans; Isoxazoles; Male; Middle Aged; Polymorphism, Single Nucleotide; Prevalence; Severity of Illness Index; Topiramate; Young Adult; Zonisamide | 2011 |
Zonisamide for migraine prophylaxis in topiramate-intolerant patients: an observational study.
Topics: Adult; Anticonvulsants; Female; Follow-Up Studies; Fructose; Humans; Incidence; Isoxazoles; Middle Aged; Migraine Disorders; Mood Disorders; Paresthesia; Prospective Studies; Severity of Illness Index; Topiramate; Treatment Outcome; Zonisamide | 2011 |
Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Glial Fibrillary Acidic Protein; Isoxazoles; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Growth Factors; Neurons; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Zonisamide | 2011 |
A novel hypothesized clinical implication of zonisamide for autism.
Topics: Antioxidants; Autistic Disorder; Humans; Isoxazoles; Zonisamide | 2011 |
Moderate toxic effects following acute zonisamide overdose.
Topics: Adult; Anticonvulsants; Central Nervous System Diseases; Drug Overdose; Epilepsies, Partial; Female; Humans; Isoxazoles; Zonisamide | 2011 |
Zonisamide toxicity in a patient with an intentional overdose.
Topics: Drug Overdose; Female; Humans; Isoxazoles; Suicide, Attempted; Young Adult; Zonisamide | 2011 |
The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Referral and Consultation; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult; Zonisamide | 2011 |
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Ethosuximide; Isoxazoles; Levetiracetam; Male; Piracetam; Rats; Rats, Wistar; Seizures; Zonisamide | 2011 |
Dramatic response to zonisamide of post-subarachnoid hemorrhage Holmes' tremor.
Topics: Aged; Anticonvulsants; Brain Edema; Female; Humans; Image Processing, Computer-Assisted; Isoxazoles; Magnetic Resonance Imaging; Neurologic Examination; Subarachnoid Hemorrhage; Tremor; Zonisamide | 2012 |
Our clinical experience with zonisamide in resistant generalized epilepsy syndromes.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Confusion; Disorders of Excessive Somnolence; Drug Resistance; Epilepsies, Myoclonic; Epilepsy, Absence; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Middle Aged; Prospective Studies; Spasms, Infantile; Treatment Outcome; Weight Loss; Zonisamide | 2011 |
Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Epilepsy; Female; Isoxazoles; Zonisamide | 2011 |
A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Hippocampus; Isoxazoles; Long-Term Potentiation; Male; Neuroprotective Agents; Nitric Oxide; Organ Culture Techniques; Rats; Rats, Wistar; Signal Transduction; Zonisamide | 2011 |
Zonisamide produces weight loss in psychotropic drug-treated psychiatric outpatients.
Topics: Adult; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Outpatients; Overweight; Psychotropic Drugs; Severity of Illness Index; Treatment Outcome; Weight Gain; Weight Loss; Zonisamide | 2011 |
Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma.
Topics: Anticonvulsants; Calibration; Chromatography, Thin Layer; Drug Monitoring; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Linear Models; Mass Spectrometry; Piracetam; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Triazines; Zonisamide | 2011 |
HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells.
Topics: Anticonvulsants; Caspase 3; Caspase Inhibitors; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Isoxazoles; Neuroblastoma; Ubiquitin-Protein Ligases; Zonisamide | 2012 |
Case of drug rash with eosinophilia and systemic symptoms induced by zonisamide and reactivation of human herpes virus 7.
Topics: Aged; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; Herpesvirus 7, Human; Humans; Isoxazoles; Male; Roseolovirus Infections; Syndrome; Zonisamide | 2011 |
Riluzole elevates GLT-1 activity and levels in striatal astrocytes.
Topics: Animals; Astrocytes; Ceftriaxone; Cells, Cultured; Excitatory Amino Acid Transporter 2; Glutamic Acid; Isoxazoles; Mice; Neostriatum; Neuroprotective Agents; Riluzole; Up-Regulation; Zonisamide | 2012 |
Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.
Topics: Anticonvulsants; Cognition Disorders; Corpus Callosum; Cortical Synchronization; Drug Resistance; Electroencephalography; Functional Laterality; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Myoclonus; Neurosurgical Procedures; Seizures; Syncope; Valproic Acid; Young Adult; Zonisamide | 2012 |
Patients with eating disorders (ED) treated with Zonisamide.
Topics: Adult; Anticonvulsants; Feeding and Eating Disorders; Humans; Isoxazoles; Psychotropic Drugs; Young Adult; Zonisamide | 2011 |
Impact of antiepileptic drugs on genesis of psychosis.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Complex Partial; Female; Follow-Up Studies; Humans; International Classification of Diseases; Isoxazoles; Male; Middle Aged; Phenytoin; Psychotic Disorders; Retrospective Studies; Young Adult; Zonisamide | 2012 |
Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Leptin; Linear Models; Middle Aged; Obesity; Prospective Studies; Weight Loss; Young Adult; Zonisamide | 2012 |
Actigraphic study of tremor before and after treatment with zonisamide in patients with Parkinson's disease.
Topics: Actigraphy; Anticonvulsants; Humans; Isoxazoles; Motor Activity; Parkinson Disease; Treatment Outcome; Tremor; Zonisamide | 2012 |
Zonisamide up-regulated the mRNAs encoding astrocytic anti-oxidative and neurotrophic factors.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Cells, Cultured; Isoxazoles; Male; Nerve Growth Factors; Organ Culture Techniques; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation; Zonisamide | 2012 |
Another option for first-line treatment of partial epilepsy?
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Zonisamide | 2012 |
Zonisamide for the treatment of self-inflicted dermatoses related to impulse control disorders.
Topics: Adolescent; Adult; Anticonvulsants; Disruptive, Impulse Control, and Conduct Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Self-Injurious Behavior; Skin Diseases; Treatment Outcome; Young Adult; Zonisamide | 2012 |
Combination therapy of zonisamide with aripiprazole on ECT- and benzodiazepine-resistant periodic catatonia.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Drug Therapy, Combination; Electroconvulsive Therapy; Humans; Isoxazoles; Male; Piperazines; Quinolones; Schizophrenia, Catatonic; Zonisamide | 2012 |
Zonisamide: no magic bullet.
Topics: Female; Humans; Isoxazoles; Male; Obesity; Weight Loss; Zonisamide | 2012 |
Effect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with Parkinson's disease.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Drug Therapy, Combination; Gene Expression; Gene Expression Profiling; Isoxazoles; Levodopa; Male; Oligonucleotide Array Sequence Analysis; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Zonisamide | 2012 |
[Clinical application of newer anti-epileptic drugs].
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Pregnancy; Pregnancy Complications; Topiramate; Triazines; Zonisamide | 2012 |
Zonisamide attenuates MPP+-induced oxidative toxicity through modulation of Ca2+ signaling and caspase-3 activity in neuronal PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium Signaling; Caspase 3; Cell Survival; Cytosol; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Ions; Isoxazoles; Lipid Peroxidation; Neurons; Oxidative Stress; PC12 Cells; Rats; Zonisamide | 2013 |
Effects of zonisamide as add-on therapy on sleep-wake cycle in focal epilepsy: a polysomnographic study.
Topics: Adult; Aged; Anticonvulsants; Cerebral Cortex; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Sleep; Treatment Outcome; Zonisamide | 2013 |
Zonisamide for seizures in Parkinson's disease with dementia.
Topics: Aged; Anticonvulsants; Dementia; Humans; Isoxazoles; Male; Parkinson Disease; Seizures; Zonisamide | 2013 |
Risk factors for hyperammonemia in pediatric patients with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Infant; Isoxazoles; Male; Phenobarbital; Phenytoin; Retrospective Studies; Risk Factors; Sex Factors; Topiramate; Valproic Acid; Zonisamide | 2013 |
Partial epilepsy and developmental delay in infant with ring chromosome 14.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Chromosome Disorders; Chromosomes, Human, Pair 14; Clobazam; Developmental Disabilities; Epilepsies, Partial; Female; Humans; Infant; Isoxazoles; Phenobarbital; Ring Chromosomes; Syndrome; Zonisamide | 2013 |
Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model.
Topics: Animals; Basilar Artery; Disease Models, Animal; Hippocampus; Isoxazoles; Male; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial; Zonisamide | 2013 |
[Othello syndrome secondary to zonisamide].
Topics: Adult; Anticonvulsants; Brain Diseases; Cysts; Delusions; Drug Substitution; Drug Therapy, Combination; Epilepsies, Partial; Humans; Isoxazoles; Jealousy; Male; Phenytoin; Syndrome; Zonisamide | 2014 |
Safety and tolerability of zonisamide in elderly patients with epilepsy.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Databases, Bibliographic; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2013 |
Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dexamethasone; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Ethosuximide; Evoked Potentials, Auditory, Brain Stem; Female; Glucocorticoids; Hearing Loss, Noise-Induced; Isoxazoles; Male; Methylprednisolone; Mice; Mice, Inbred C57BL; Zonisamide | 2013 |
Study on the interaction of the epilepsy drug, zonisamide with human serum albumin (HSA) by spectroscopic and molecular docking techniques.
Topics: Anticonvulsants; Circular Dichroism; Humans; Isoxazoles; Molecular Docking Simulation; Protein Binding; Protein Conformation; Serum Albumin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics; Zonisamide | 2013 |
Management and monitoring of patients treated with zonisamide: the OZONE study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Collection; Data Interpretation, Statistical; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Monitoring, Physiologic; Quality of Life; Seizures; Treatment Outcome; Young Adult; Zonisamide | 2013 |
Application of surfactant assisted dispersive liquid-liquid microextraction as an efficient sample treatment technique for preconcentration and trace detection of zonisamide and carbamazepine in urine and plasma samples.
Topics: 1-Octanol; Carbamazepine; Cetrimonium; Cetrimonium Compounds; Chromatography, High Pressure Liquid; Dyssomnias; Humans; Isoxazoles; Linear Models; Liquid Phase Microextraction; Osmolar Concentration; Reproducibility of Results; Sodium Hydroxide; Surface-Active Agents; Zonisamide | 2013 |
Two nursing mothers treated with zonisamide: Should breast-feeding be avoided?
Topics: Adult; Anticonvulsants; Biological Availability; Breast Feeding; Child Development; Epilepsy; Female; Fetal Blood; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Isoxazoles; Lactation; Male; Milk, Human; Zonisamide | 2014 |
Psychiatric adverse effects of zonisamide in patients with epilepsy and mental disorder comorbidities.
Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Electroencephalography; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Disorders; Middle Aged; Psychotic Disorders; Zonisamide | 2013 |
Protective effects of zonisamide against rotenone-induced neurotoxicity.
Topics: Apoptosis; Cell Line, Tumor; Humans; Isoxazoles; Membrane Potential, Mitochondrial; Nervous System; Reactive Oxygen Species; Rotenone; Zonisamide | 2013 |
[Bilateral urolithiasis with zonisamide developed for a short period of time in a 10-year-old girl with intractable epilepsy].
Topics: Anticonvulsants; Child; Dehydration; Disease Progression; Epilepsy, Tonic-Clonic; Female; Humans; Hydronephrosis; Isoxazoles; Nephrostomy, Percutaneous; Stents; Time Factors; Treatment Outcome; Ureter; Urolithiasis; Zonisamide | 2013 |
Investigation of the effects of Zn2+, Ca2+ and Na+ ions on the interaction between zonisamide and human serum albumin (HSA) by spectroscopic methods.
Topics: Binding Sites; Calcium; Circular Dichroism; Energy Transfer; Humans; Hydrogen-Ion Concentration; Ions; Isoxazoles; Kinetics; Protein Structure, Secondary; Serum Albumin; Sodium; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Zinc; Zonisamide | 2014 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Isoxazoles; Ketanserin; Male; Morphine; Ondansetron; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Streptozocin; Zonisamide | 2014 |
Impact of pregnancy on zonisamide pharmacokinetics in rabbits.
Topics: Administration, Oral; Animals; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Pregnancy; Rabbits; Tandem Mass Spectrometry; Zonisamide | 2013 |
Association between topiramate and zonisamide use during pregnancy and low birth weight.
Topics: Adult; Anticonvulsants; Birth Weight; Cohort Studies; Female; Fructose; Humans; Isoxazoles; Pregnancy; Registries; Topiramate; Zonisamide | 2014 |
In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Transformed; Dogs; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Pregabalin; Rhodamine 123; Swine; Transfection; Triazoles; Zonisamide | 2014 |
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cell Count; Dependovirus; Disease Models, Animal; Dopaminergic Neurons; Isoxazoles; Male; Mice; Neuroprotective Agents; Parkinson Disease; Protein Aggregation, Pathological; Rats; Substantia Nigra; Time Factors; Zonisamide | 2014 |
Ezogabine treatment of childhood absence epilepsy.
Topics: Anticonvulsants; Carbamates; Drug Interactions; Electroencephalography; Epilepsy, Absence; Female; Humans; Isoxazoles; Lamotrigine; Middle Aged; Phenylenediamines; Treatment Outcome; Triazines; Zonisamide | 2014 |
DIHS/DRESS with remarkable eosinophilic pneumonia caused by zonisamide.
Topics: Adrenal Cortex Hormones; Biopsy; Drug Hypersensitivity Syndrome; Female; Humans; Isoxazoles; Middle Aged; Prednisolone; Pulmonary Eosinophilia; Tomography, X-Ray Computed; Treatment Outcome; Zonisamide | 2015 |
A simple and accurate liquid chromatography-tandem mass spectrometry method for quantification of zonisamide in plasma and its application to a pharmacokinetic study.
Topics: Animals; Drug Stability; Female; Humans; Isoxazoles; Plasma; Rabbits; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Zonisamide | 2014 |
Zonisamide for refractory juvenile absence epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Absence; Female; Humans; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult; Zonisamide | 2014 |
Zonisamide attenuates hyperoxia-induced apoptosis in the developing rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Disease Models, Animal; Hyperoxia; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Zonisamide | 2014 |
Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks.
Topics: Acetamides; Anticonvulsants; Arrhythmias, Cardiac; Child, Preschool; Comorbidity; Humans; Hypoplastic Left Heart Syndrome; Isoxazoles; Lacosamide; Levetiracetam; Male; Piracetam; Seizures; Tachycardia, Sinus; Treatment Outcome; Zonisamide | 2015 |
Safety and tolerability of zonisamide in paediatric patients with epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Female; Humans; Isoxazoles; Male; Pediatrics; Treatment Outcome; Zonisamide | 2014 |
Zonisamide: pharmacokinetics, efficacy, and adverse events in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Male; Metabolic Clearance Rate; Retrospective Studies; Sex Factors; Treatment Outcome; Zonisamide | 2014 |
Efficacy and safety of zonisamide in Thai children and adolescents with intractable seizures.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Retrospective Studies; Seizures; Thailand; Zonisamide | 2015 |
Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum Stress; Half-Life; Humans; Isoxazoles; Male; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease; Substantia Nigra; Thapsigargin; Tunicamycin; Zonisamide | 2015 |
Comparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Excipients; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Lactose; Molecular Weight; Oxides; Polyethylene Glycols; Propranolol; Solubility; Tablets; Theophylline; Water; Zonisamide | 2016 |
Zonisamide-induced angle closure and myopic shift.
Topics: Acute Disease; Adult; Anticonvulsants; Female; Glaucoma, Angle-Closure; Gonioscopy; Humans; Intraocular Pressure; Isoxazoles; Migraine Disorders; Myopia; Visual Acuity; Zonisamide | 2015 |
[Reversible neuropsychological deterioration associated to zonisamide in a paediatric patient with tuberous sclerosis].
Topics: Acetamides; Anticonvulsants; Benzodiazepines; Child; Clobazam; Cognition Disorders; Dibenzazepines; Drug Substitution; Drug Therapy, Combination; Epilepsies, Partial; Frontal Lobe; Humans; Isoxazoles; Lacosamide; Language Disorders; Learning Disabilities; Male; Memory Disorders; Neuroimaging; Nitriles; Pyridones; Tuberous Sclerosis; Zonisamide | 2015 |
Retention rate of zonisamide in intractable epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Denmark; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Male; Middle Aged; Norway; Patient Dropouts; Piracetam; Quality of Life; Sweden; Treatment Outcome; Triazines; Young Adult; Zonisamide | 2015 |
Investigation of Drug Release from PEO Tablet Matrices in the Presence of Vitamin E as Antioxidant.
Topics: Antioxidants; Drug Liberation; Humans; Isoxazoles; Molecular Structure; Molecular Weight; Polyethylene Glycols; Propranolol; Solubility; Tablets; Theophylline; Vitamin E; Zonisamide | 2015 |
Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease.
Topics: Animals; Antioxidants; Antiparkinson Agents; Brain; Brain-Derived Neurotrophic Factor; Dopaminergic Neurons; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Zonisamide | 2015 |
Erythema multiforme associated with zonisamide in a dog.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Erythema Multiforme; Isoxazoles; Male; Skin; Zonisamide | 2015 |
Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy.
Topics: Anticonvulsants; Drug Interactions; Epilepsy; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Zonisamide | 2015 |
Feasibility of amlodipine besylate, chloroquine phosphate, dapsone, phenytoin, pyridoxine hydrochloride, sulfadiazine, sulfasalazine, tetracycline hydrochloride, trimethoprim and zonisamide in SyrSpend(®) SF PH4 oral suspensions.
Topics: Administration, Oral; Amlodipine; Chloroquine; Chromatography, High Pressure Liquid; Dapsone; Drug Stability; Drug Storage; Feasibility Studies; Hydrogen-Ion Concentration; Isoxazoles; Phenytoin; Pyridoxine; Sulfadiazine; Sulfasalazine; Suspensions; Tetracycline; Trimethoprim; Zonisamide | 2016 |
Safety and tolerability of an oral zonisamide loading dose.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Young Adult; Zonisamide | 2015 |
Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model.
Topics: Animals; Autografts; Cell Line, Tumor; Cells, Cultured; Cytoprotection; Isoxazoles; Male; Mice, Inbred C57BL; Models, Animal; Motor Neurons; Nerve Growth Factors; Nerve Regeneration; Neurites; Oxidative Stress; Receptors, Nerve Growth Factor; RNA, Messenger; Sciatic Nerve; Time Factors; Up-Regulation; Zonisamide | 2015 |
Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Tandem Mass Spectrometry; Topiramate; Triazines; Zonisamide | 2016 |
Zonisamide-induced Acute-on-Chronic Liver Failure: First Report.
Topics: Acute-On-Chronic Liver Failure; Adult; Alcoholism; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Zonisamide | 2016 |
Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Seizures; Treatment Outcome; Young Adult; Zonisamide | 2016 |
Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Isoxazoles; Kindling, Neurologic; Nitriles; Pyridones; Rats; Rats, Sprague-Dawley; Zonisamide | 2016 |
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Japan; Lamotrigine; Levetiracetam; Male; Phenobarbital; Phenytoin; Piracetam; Triazines; Valproic Acid; Young Adult; Zonisamide | 2016 |
Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein.
Topics: Anticonvulsants; Biomarkers; C-Reactive Protein; Carbamazepine; Drug Substitution; Drug Therapy, Combination; Epilepsies, Partial; Female; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Lipids; Male; Middle Aged; Phenytoin; Piracetam; Time Factors; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2016 |
Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit.
Topics: Cohort Studies; Electroencephalography; Female; Fructose; Humans; Infant; Isoxazoles; Male; Recurrence; Spasms, Infantile; Statistics, Nonparametric; Survival Analysis; Topiramate; Video Recording; Vigabatrin; Zonisamide | 2016 |
[A 6-month-old female patient who suffered clustering of afebrile seizures (part 2)].
Topics: Anticonvulsants; Carbamazepine; Drug Eruptions; Female; Genetic Testing; Histocompatibility Testing; Humans; Infant; Isoxazoles; Pharmacogenetics; Seizures, Febrile; Zonisamide | 2016 |
[Study of the efficacy of low-dose synthetic ACTH therapy without tapering to treat West syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Drug Therapy, Combination; Feasibility Studies; Female; Humans; Infant; Isoxazoles; Male; Recurrence; Spasms, Infantile; Time Factors; Treatment Outcome; Zonisamide | 2016 |
Complete Recovery After Acute Zonisamide Overdose in an Adolescent Female.
Topics: Adolescent; Anticonvulsants; Catecholamines; Drug Overdose; Female; Humans; Intubation, Intratracheal; Isoxazoles; Mood Disorders; Respiration, Artificial; Suicide, Attempted; Zonisamide | 2018 |
The Anticonvulsant Zonisamide Inhibits Hydroxyl Radical Generated from Methylguanidine.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydroxyl Radical; Isoxazoles; Methylguanidine; Spectrum Analysis; Zonisamide | 2016 |
Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets.
Topics: Delayed-Action Preparations; Drug Liberation; Drug Stability; Hardness; Isoxazoles; Polyethylene Glycols; Propranolol; Solubility; Tablets; Theophylline; Zonisamide | 2017 |
Effect of topiramate and zonisamide on fMRI cognitive networks.
Topics: Adult; Anticonvulsants; Brain; Cognition Disorders; Cross-Sectional Studies; Epilepsies, Partial; Female; Fructose; Functional Laterality; Humans; Image Processing, Computer-Assisted; Isoxazoles; Language; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Oxygen; Retrospective Studies; Topiramate; Zonisamide | 2017 |
An innovative method for the preparation of high API-loaded hollow spherical granules for use in controlled-release formulation.
Topics: Delayed-Action Preparations; Excipients; Indomethacin; Isoxazoles; Particle Size; Polymers; Tablets; Technology, Pharmaceutical; Zonisamide | 2017 |
The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.
Topics: Administration, Oral; Alcoholism; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Ethanol; Female; Hippocampus; Isoxazoles; Male; Rabbits; Zonisamide | 2017 |
Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide.
Topics: Adiposity; Animals; Antioxidants; Antipsychotic Agents; Benzodiazepines; Body Weight; Drug Therapy, Combination; Eating; Female; Glucose; Homeostasis; Isoxazoles; Lipid Metabolism; Lipolysis; Motor Activity; Olanzapine; Oxygen Consumption; Random Allocation; Rats, Sprague-Dawley; Triglycerides; Zonisamide | 2017 |
Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury.
Topics: Acute Disease; Animals; Antioxidants; Axons; Blood-Brain Barrier; Cell Death; Chromatography, Gel; Dioxanes; Drug Carriers; Drug Delivery Systems; Drug Liberation; Isoxazoles; Magnetic Resonance Imaging; Mice; Micelles; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Spinal Cord Injuries; X-Ray Diffraction; Zonisamide | 2017 |
Tolerability of lacosamide or zonisamide in elderly patients with seizures.
Topics: Acetamides; Aged; Anticonvulsants; Dizziness; Female; Gait; Humans; Isoxazoles; Lacosamide; Male; Postural Balance; Retrospective Studies; Seizures; Zonisamide | 2017 |
Zonisamide ameliorates levodopa-induced dyskinesia and reduces expression of striatal genes in Parkinson model rats.
Topics: Animals; Anticonvulsants; Corpus Striatum; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Gene Expression; Isoxazoles; Levodopa; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Zonisamide | 2017 |
Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Astrocytes; Brain; Dopamine; Exploratory Behavior; Homovanillic Acid; Isoxazoles; Locomotion; Male; Mice, Inbred C57BL; Monoamine Oxidase; Neurons; Parkinson Disease; Social Behavior; Zonisamide | 2017 |
Chromatographic determination of zonisamide, topiramate and sulpiride in plasma by a fluorescent 'turn-on' chemosensor.
Topics: Adult; Anticonvulsants; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Epilepsy; Female; Fructose; Humans; Hydrogen-Ion Concentration; Isoxazoles; Limit of Detection; Linear Models; Male; Spectrometry, Fluorescence; Sulpiride; Time Factors; Topiramate; Water; Zonisamide | 2017 |
Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Seizures; Treatment Outcome; Weight Loss; Zonisamide | 2017 |
Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Diagnosis, Differential; Drug Hypersensitivity; Epilepsy; Isoxazoles; Male; Seizures; Zonisamide | 2017 |
[Early onset epileptic encephalopathy in a patient with mutation in
Topics: Age of Onset; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Drug Resistant Epilepsy; Drug Substitution; Electroencephalography; Heterozygote; Humans; Intellectual Disability; Isoxazoles; Male; Mutation, Missense; NAV1.6 Voltage-Gated Sodium Channel; Phenytoin; Point Mutation; Zonisamide | 2017 |
Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.
Topics: Acetamides; Anticonvulsants; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Isoxazoles; Lacosamide; Levetiracetam; Piracetam; Zonisamide | 2018 |
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammation; Isoxazoles; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Seizures; Zonisamide | 2018 |
First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea.
Topics: Adult; Anticonvulsants; Blotting, Southern; Cystatin B; Female; Genetic Predisposition to Disease; Humans; Isoxazoles; Levetiracetam; Piracetam; Republic of Korea; Seizures; Treatment Outcome; Unverricht-Lundborg Syndrome; Valproic Acid; Zonisamide | 2018 |
Garcinol, an effective monoamine oxidase-B inhibitor for the treatment of Parkinson's disease.
Topics: Humans; Inflammation; Isoxazoles; Levodopa; Ligands; Molecular Conformation; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidative Stress; Parkinson Disease; Phytochemicals; Phytotherapy; Reactive Oxygen Species; Terpenes; Zonisamide | 2018 |
[Progress in synaptic mechanism in epileptogenesis].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; N-Ethylmaleimide-Sensitive Proteins; Nerve Tissue Proteins; Qa-SNARE Proteins; Recurrence; Synapses; Synaptic Vesicles; Zonisamide | 2018 |
Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction.
Topics: Adult; Anticonvulsants; Area Under Curve; Female; Healthy Volunteers; Humans; Isoxazoles; Male; Metabolomics; Pharmacological Phenomena; Therapeutic Equivalency; Young Adult; Zonisamide | 2018 |
Teratogenic effects of zonisamide.
Topics: Anticonvulsants; Humans; Isoxazoles; Zonisamide | 2021 |
Presumed zonisamide-induced blood dyscrasias in four dogs.
Topics: Animals; Anticonvulsants; Dogs; Isoxazoles; Leukocyte Count; Zonisamide | 2022 |