Page last updated: 2024-08-21

isoxazoles and uridine

isoxazoles has been researched along with uridine in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (7.32)	18.7374
1990's	17 (41.46)	18.2507
2000's	19 (46.34)	29.6817
2010's	2 (4.88)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berger, AE; Bhuyan, BK; Blowers, CL; Kuentzel, SL; Neil, GL	1
Cheng, CC; Daves, GD	1
Fox, MP; McKinlay, MA; Otto, MJ	1
Caulfield, JP; Cherwinski, HM; Cheung, P; Cohn, RG; Nakano, G; Ransom, JT; Webster, DJ; Xu, YZ; Young, JM	1
Bartlett, RR; Müller, S; Zeitter, D; Zielinski, T	1
Cao, W; Morris, RE; Nair, RV	2
Chong, AS; Finnegan, A; Gong, H; Williams, JW; Xu, X	1
Cao, W; Morris, RE; Shorthouse, R; Silva, HT	1
Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Rafael, E; Sundberg, B; Wennberg, L; Zhu, S	1
Blinder, L; Chong, AS; Finnegan, A; Gong, H; Shen, J; Williams, JW; Xu, X	1
Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X	1
Chong, AS; Finnegan, A; Gong, H; Jäck, HM; Siemasko, K; Williams, JW	1
Carrey, EA; Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Richards, DF; Rückemann, K; Simmonds, HA	1
Czech, J; Schorlemmer, HU; Schwab, W	1
Amano, Y; Kitagawa, H; Mizushima, Y; Ogata, K	1
Huang, Q; Lau, SS; Monks, TJ	1
Blinder, L; Chong, AS; Clardy, C; Foster, P; Huang, W; Liu, W; Luo, J; Ma, L; Shen, J; Williams, JA; Xiao, F; Xu, W; Xu, X	1
Czech, J; Kurrle, R; Schorlemmer, HU	1
Blinder, L; Chong, AS; Knight, DA; Lurain, NS; Miller, DM; Sedmak, DD; Shen, J; Waldman, WJ; Williams, JW	1
Aggarwal, BB; Manna, SK; Mukhopadhyay, A	1
Fehr, T; Ochsenbein, AF; Pinschewer, DD; Zinkernagel, RM	1
Bickerstaff, A; Gordillo, G; Knight, DA; Orosz, CG; Orosz, K; Waldman, WJ	1
Collins, M; Graves, LM; Huang, M; Mitchell, BS; Wang, Y	1
Mall, JW; Myers, JA; Philipp, AW; Pollmann, C; Saclarides, TJ; Xu, X	1
Chiacchio, U; Corsaro, A; Iannazzo, D; Mastino, A; Piperno, A; Pistarà, V; Rescifina, A; Romeo, G; Romeo, R; Valveri, V	1
Häyry, P; Savikko, J; Von Willebrand, E	1
Jung, S; Korn, T; Magnus, T; Toyka, K	1
Aringer, M; Eselböck, D; Grisar, J; Köller, MD; Pietschmann, P; Smolen, JS; Steiner, CW; Stummvoll, GH; Wagner, L; Zierhut, B; Zwölfer, B	1
Chong, AS; Knight, DA; Ma, L; Meister, GT; Shen, J; Waldman, WJ; Williams, JW; Yin, DP; Zeng, H	1
Stuhlmeier, KM	1
Geyeregger, R; Hörl, WH; Kirsch, BM; Säemann, MD; Stuhlmeier, KM; Stulnig, TM; Zeyda, M; Zlabinger, GJ	1
Chong, AS; Knight, DA; Meister, GT; Shen, J; Waldman, WJ; Williams, JW; Zeng, H	1
Detter, C; Deuse, T; Koch-Nolte, F; Reichenspurner, H; Schrepfer, S	1
Hilbrands, LB; Joosten, I; Koenen, HJ; Kreijveld, E; van Hooff, HJ	1
Guerne, PA; Magne, D; Mézin, F; Palmer, G	1
Nakayamada, S; Ra, C; Saito, K; Sawamukai, N; Tanaka, Y; Yamaoka, K	1
Adam, C; Baumann, P; Bumeder, I; Mandl-Weber, S; Oduncu, F; Schmidmaier, R; Völkl, A	1
Fukushima, R; Hirashiba, M; Hishikawa, A; Kanamori, S; Kaneto, M; Kitagawa, H; Muranaka, R	1
Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Phillips, JL; Tanguay, RL	1
Ichikawa, S; Matsuda, A; Yamaguchi, M	1

Reviews

1 review(s) available for isoxazoles and uridine

Article	Year
The chemistry and biochemistry of C-nucleosides. Progress in medicinal chemistry, 1976, Volume: 13 Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine	1976

Other Studies

40 other study(ies) available for isoxazoles and uridine

Article	Year
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125). Advances in enzyme regulation, 1978, Volume: 17 Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Glycine; Isoxazoles; Leukemia L1210; Leukemia P388; Macromolecular Substances; Male; Mice; Oxazoles; Sex Factors; Thymidine; Uridine; Valine	1978
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug. Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:1 Topics: Antiviral Agents; Cells, Cultured; Centrifugation, Density Gradient; Hot Temperature; Humans; Isoxazoles; Oxazoles; Poliovirus; Rhinovirus; Sucrose; Time Factors; Uridine; Virus Replication	1986
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:2 Topics: Animals; Cell Cycle; Cell Nucleolus; Cells, Cultured; Dihydroorotate Dehydrogenase; DNA; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Isoxazoles; Ki-67 Antigen; Leflunomide; Lymphocyte Activation; Neoplasm Proteins; Nuclear Proteins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Proliferating Cell Nuclear Antigen; Pyrimidines; Rats; RNA; T-Lymphocytes; Uridine	1995
Leflunomide, a reversible inhibitor of pyrimidine biosynthesis? Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2 Topics: Cell Division; Cell Line; Cytidine; Humans; Immunosuppressive Agents; Isoxazoles; Kinetics; Leflunomide; Pyrimidines; Uracil Nucleotides; Uridine	1995
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunology letters, 1995, Volume: 48, Issue:2 Topics: Aniline Compounds; Animals; Cell Division; Cell Line; Crotonates; Fibroblast Growth Factor 2; Growth Inhibitors; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Muscle, Smooth; Nitriles; Toluidines; Uridine	1995
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunology letters, 1995, Volume: 47, Issue:3 Topics: Aniline Compounds; Animals; Cell Division; Cell Line, Transformed; Crotonates; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Muscle, Smooth; Nitriles; Toluidines; Uridine	1995
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Biochemical pharmacology, 1996, Aug-23, Volume: 52, Issue:4 Topics: Animals; Blotting, Western; Dose-Response Relationship, Drug; Immunosuppressive Agents; Isoxazoles; Leflunomide; Leukemia, Experimental; Mice; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Uridine	1996
Mechanism of action of leflunomide: in vivo uridine administration reverses its inhibition of lymphocyte proliferation. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Animals; Dihydroorotate Dehydrogenase; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Inbred Lew; Thymidine; Uridine	1996
Efficacy of immunosuppressive drugs in islet xenotransplantation: leflunomide in combination with cyclosporine and mycophenolate mofetil prevents islet xenograft rejection in the pig-to-rat model. Transplantation, 1997, May-15, Volume: 63, Issue:9 Topics: Animals; Antibodies; Complement System Proteins; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Graft Rejection; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Mice; Pregnancy; Rats; Swine; Time Factors; Transplantation, Heterologous; Uridine	1997
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice. Journal of immunology (Baltimore, Md. : 1950), 1997, Jul-01, Volume: 159, Issue:1 Topics: Aniline Compounds; Animals; Autoimmune Diseases; Crotonates; Dihydroorotate Dehydrogenase; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymph Nodes; Lymphoproliferative Disorders; Mice; Mice, Mutant Strains; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidine Nucleotides; Toluidines; Uridine	1997
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2 Topics: Animals; Autoantibodies; Autoimmune Diseases; Biphenyl Compounds; Cytidine Triphosphate; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Phosphorylation; Tyrosine; Uridine; Uridine Triphosphate	1997
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. Journal of immunology (Baltimore, Md. : 1950), 1998, Feb-15, Volume: 160, Issue:4 Topics: Animals; B-Lymphocytes; Binding, Competitive; DNA-Binding Proteins; Growth Inhibitors; Immunoglobulin G; Immunosuppressive Agents; Interleukin-4; Isoxazoles; Janus Kinase 3; Leflunomide; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Tyrosine; Uridine	1998
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans. The Journal of biological chemistry, 1998, Aug-21, Volume: 273, Issue:34 Topics: Adenosine Triphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Leflunomide; Lymphocyte Activation; Mice; Mitogens; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phytohemagglutinins; Pyrimidines; T-Lymphocytes; Uridine; Uridine Triphosphate	1998
Inhibition of PDGF-stimulated rat smooth muscle cell proliferation by MNA 279 and MNA 715. Transplantation proceedings, 1998, Volume: 30, Issue:8 Topics: Alkynes; Animals; Aorta, Thoracic; Cell Division; Cell Line; Dihydroorotate Dehydrogenase; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Platelet-Derived Growth Factor; Rats; Uridine	1998
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2 Topics: Administration, Oral; Aniline Compounds; Animals; Antibody Specificity; Crotonates; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxybutyrates; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Nitriles; Ovalbumin; Rats; Rats, Inbred BN; Toluidines; Uridine	1999
Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine. The Biochemical journal, 1999, Jul-01, Volume: 341 ( Pt 1) Topics: Animals; Aspartic Acid; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Culture Media; Cytidine; Cytidine Triphosphate; Diazooxonorleucine; DNA Damage; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Glutamine; Isoxazoles; Ketoglutaric Acids; Kidney Tubules, Proximal; RNA, Messenger; Salts; Swine; Transcription Factor CHOP; Transcription Factors; Uridine	1999
In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression. Transplantation, 1999, Jul-15, Volume: 68, Issue:1 Topics: Aniline Compounds; Animals; Cricetinae; Crotonates; Graft Rejection; Heart Transplantation; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Lymph Nodes; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nitriles; Pyrimidine Nucleotides; Rats; Rats, Inbred Lew; Spleen; Toluidines; Transplantation, Heterologous; Transplantation, Homologous; Uridine	1999
The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 2 Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Caproates; Cell Division; Crotonates; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Platelet-Derived Growth Factor; Rats; Toluidines; Uridine	1999
Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology, 1999, Volume: 42, Issue:5-6 Topics: Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Drug Resistance, Microbial; Drug Resistance, Multiple; Endothelium, Vascular; Fibroblasts; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Uridine	1999
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. Journal of immunology (Baltimore, Md. : 1950), 2000, Nov-15, Volume: 165, Issue:10 Topics: Apoptosis; Caspase Inhibitors; Caspases; Cells, Cultured; Cytotoxicity, Immunologic; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Growth Inhibitors; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; Immunosuppressive Agents; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leflunomide; Lipid Peroxidation; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor; Signal Transduction; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Uridine	2000
Leflunomide-mediated suppression of antiviral antibody and Tcell responses: differential restoration by uridine. Transplantation, 2001, Aug-27, Volume: 72, Issue:4 Topics: Animals; Antibodies, Viral; Antibody Formation; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Diabetes Mellitus; Dose-Response Relationship, Drug; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Transgenic; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Uridine; Vesicular stomatitis Indiana virus	2001
Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. Transplantation, 2001, Nov-15, Volume: 72, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cells, Cultured; Culture Media; Cyclosporine; Endothelium, Vascular; Humans; Isoxazoles; Leflunomide; Mice; Microcirculation; Models, Animal; Tacrolimus; Umbilical Veins; Uridine	2001
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. Molecular pharmacology, 2002, Volume: 62, Issue:3 Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Cycle Proteins; Cell Differentiation; Cell Division; Crotonates; Cytidine; Cytidine Triphosphate; Dihydroorotase; Drug Interactions; Gene Expression; Glycophorins; Humans; Hydroxybutyrates; Isoxazoles; K562 Cells; Leflunomide; Multienzyme Complexes; Nitriles; Pyrimidines; S Phase; Toluidines; Uridine; Uridine Triphosphate	2002
[Leflunomide reduces the angiogenesis score and tumor growth of subcutaneously implanted colon carcinoma cells in the mouse model]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2002, Volume: 73, Issue:7 Topics: Administration, Oral; Animals; Capillaries; Cell Division; Colonic Neoplasms; HT29 Cells; Humans; Injections, Intraperitoneal; Isoxazoles; Leflunomide; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Random Allocation; Uridine	2002
Enantioselective syntheses and cytotoxicity of N,O-nucleosides. Journal of medicinal chemistry, 2003, Aug-14, Volume: 46, Issue:17 Topics: Antineoplastic Agents; Antiviral Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line; Dideoxynucleosides; fas Receptor; Humans; Isoxazoles; Lymphoid Tissue; Molecular Conformation; Monocytes; Quantum Theory; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine	2003
Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. Transplantation, 2003, Aug-15, Volume: 76, Issue:3 Topics: Alkynes; Angiogenesis Inhibitors; Animals; Benzamides; Blood Vessels; Constriction, Pathologic; Dihydroorotate Dehydrogenase; Graft Rejection; Imatinib Mesylate; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Wistar; Recurrence; Tunica Intima; Uridine; Vascular Diseases	2003
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion. Journal of leukocyte biology, 2004, Volume: 76, Issue:5 Topics: Adoptive Transfer; Animals; Animals, Newborn; Antigens, CD; B7-2 Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-2; Isoxazoles; Leflunomide; Membrane Glycoproteins; Microglia; Multiple Sclerosis; Myelin Basic Protein; Pyrimidines; Rats; Rats, Inbred Lew; STAT6 Transcription Factor; T-Lymphocytes, Helper-Inducer; Trans-Activators; Uridine	2004
Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:12 Topics: Antirheumatic Agents; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Flow Cytometry; Humans; Hyaluronic Acid; Isoxazoles; Leflunomide; Leukocytes, Mononuclear; Methotrexate; Uridine	2004
Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. Transplantation, 2005, Jan-15, Volume: 79, Issue:1 Topics: Alkynes; Animals; Antiviral Agents; Body Weight; Cytomegalovirus Infections; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Transplantation, Homologous; Uridine; Virus Replication	2005
Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide. Journal of immunology (Baltimore, Md. : 1950), 2005, Jun-01, Volume: 174, Issue:11 Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Enzyme Repression; Fibroblasts; Glucuronosyltransferase; Humans; Hyaluronan Synthases; Hyaluronic Acid; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; NF-kappa B; Protein Transport; Pyrimidines; RNA, Messenger; Synovial Membrane; Transcription, Genetic; Uridine	2005
Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778. Transplantation, 2005, Oct-27, Volume: 80, Issue:8 Topics: Alkynes; Antigens, CD; Cell Differentiation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Humans; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; NF-kappa B; Nitriles; T-Lymphocytes; Uridine	2005
Concurrent antiviral and immunosuppressive activities of leflunomide in vivo. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:1 Topics: Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Graft Rejection; Heart; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Lectins, C-Type; Leflunomide; Lung; Rats; Rats, Inbred Lew; Salivary Glands; Spleen; Transplants; Uridine; Viral Proteins	2006
FK778: new cellular and molecular mechanisms of action. Transplantation proceedings, 2006, Volume: 38, Issue:3 Topics: Alkynes; Animals; CD28 Antigens; Cell Adhesion; Endothelium, Vascular; Flow Cytometry; Isoxazoles; Lymphocyte Activation; Lymphocytes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Antigen, T-Cell; Tumor Necrosis Factor-alpha; Uridine	2006
The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells. Blood, 2007, Jan-01, Volume: 109, Issue:1 Topics: Adult; Alkynes; Antigens, CD; Antigens, Differentiation; CD4-Positive T-Lymphocytes; Cell Communication; Cell Division; Cells, Cultured; CTLA-4 Antigen; Cyclin-Dependent Kinase Inhibitor p27; Drug Evaluation, Preclinical; Forkhead Transcription Factors; Glucocorticoid-Induced TNFR-Related Protein; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Intracellular Signaling Peptides and Proteins; Isoantigens; Isoxazoles; L-Selectin; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Nitriles; Phosphorylation; Protein Processing, Post-Translational; Pyrimidines; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; Uridine	2007
The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:11 Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Crotonates; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Humans; Hydroxybutyrates; Interleukin-1beta; Isoxazoles; Jurkat Cells; Leflunomide; Nitriles; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Synovial Membrane; Toluidines; Tumor Necrosis Factor-alpha; Uridine	2006
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. Journal of immunology (Baltimore, Md. : 1950), 2007, Nov-15, Volume: 179, Issue:10 Topics: Aniline Compounds; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Chronic Disease; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxybutyrates; Immunosuppressive Agents; Inflammation Mediators; Isoxazoles; Leflunomide; Mast Cells; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Synovial Membrane; Synovitis; Toluidines; Uridine	2007
Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. Molecular cancer therapeutics, 2009, Volume: 8, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Cell Adhesion Molecules; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Culture Media; Dihydroorotate Dehydrogenase; Down-Regulation; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; G1 Phase; Humans; Isoxazoles; Leflunomide; Multiple Myeloma; Oxidoreductases Acting on CH-CH Group Donors; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytokine; Ribosomal Protein S6 Kinases, 70-kDa; Stromal Cells; Uridine	2009
Inhibiting the teratogenicity of the immunosuppressant leflunomide in mice by supplementation of exogenous uridine. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 108, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Dihydroorotate Dehydrogenase; Embryonic Development; Female; Fetal Viability; Fetus; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred ICR; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Pyrimidine Nucleotides; Teratogens; Uridine	2009
The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. PloS one, 2012, Volume: 7, Issue:7 Topics: Aniline Compounds; Cell Line, Tumor; Cell Proliferation; Crotonates; Cyclin-Dependent Kinase Inhibitor p21; Dihydroorotate Dehydrogenase; Fluoresceins; Gene Knockdown Techniques; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Melanoma; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Proto-Oncogene Proteins c-myc; Receptors, Aryl Hydrocarbon; Signal Transduction; Succinimides; Toluidines; Uridine	2012
Synthesis of isoxazolidine-containing uridine derivatives as caprazamycin analogues. Organic & biomolecular chemistry, 2015, Jan-28, Volume: 13, Issue:4 Topics: Anti-Bacterial Agents; Bacteria; Chemistry Techniques, Synthetic; Isoxazoles; Microbial Sensitivity Tests; Uridine	2015