isoxazoles has been researched along with transforming growth factor beta in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Aoki, Y; Cao, WW; Kao, PN; Morris, RE; Shorthouse, RA; Xu, JC | 1 |
| Boustani, MR; Fanburg, BL; Hertig, IA; Maloney, EK; White, AC | 1 |
| Benediktsson, H; Crews, G; Ebbs, A; Erickson, L; Fisniku, O; Jang, MS; Jiang, AH; Kobayashi, M; Pan, F; Paul, LC; Wynn, C | 1 |
| Chen, JQ; Li, J; Xu, SY; Yao, HW | 2 |
| Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E | 3 |
| Deng, M; Heemann, U; Huang, H; Lutz, J; Roos, M; Schmaderer, C; Strobl, M; Wagner, B | 1 |
| Bascands, JL; Calise, D; Chun, J; Grès, S; Guigné, C; Klein, J; Neau, E; Pradère, JP; Saulnier-Blache, JS; Schanstra, JP; Valet, P | 1 |
| Brizzolara, R; Clerico, P; Cutolo, M; Meroni, M; Molfetta, L; Montagna, P; Seriolo, B; Soldano, S; Sulli, A; Triolo, P; Villaggio, B | 1 |
| Akhmetshina, A; Allanore, Y; Avouac, J; Beyer, C; Dees, C; Distler, JH; Distler, O; Horn, A; Maurer, B; Palumbo, K; Sadowski, A; Schett, G; Schneider, H; Shiozawa, S; Tomcik, M; Zerr, P | 1 |
| Chai, RC; Gillespie, MT; Lang, BJ; Price, JT; Quinn, JM; Singh, PP; van der Kraan, AG; Xu, J | 1 |
| Bascands, JL; Bouloumié, A; Decaunes, P; Gres, S; Langin, D; Rancoule, C; Saulnier-Blache, JS; Valet, P; Viaud, M; Viguerie, N | 1 |
| Choi, JW; Jun, HS; Jung, JY; Li, HY; Oh, YS | 1 |
| Bacon, NA; Larre, I; Lawag, AA; Merritt, C; Rosolen, M; Smith, M; Sollars, VE | 1 |
| Chen, Q; Chen, S; Cheng, X; Li, F; Tao, Z; Wang, Y; Xiao, B; Xiao, Y | 1 |
1 trial(s) available for isoxazoles and transforming growth factor beta
| Article | Year |
|---|---|
Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.
Topics: Actins; Adipose Tissue; Animals; Collagen; Enzyme Activators; Female; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Obese; Propionates; Receptors, Lysophosphatidic Acid; Tissue Culture Techniques; Transforming Growth Factor beta | 2014 |
16 other study(ies) available for isoxazoles and transforming growth factor beta
| Article | Year |
|---|---|
A novel mechanism of action of the immunomodulatory drug, leflunomide: augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2.
Topics: Cells, Cultured; Gene Expression; Humans; Immunosuppressive Agents; Interleukin-2; Isoxazoles; Jurkat Cells; Leflunomide; Transcription, Genetic; Transforming Growth Factor beta | 1996 |
Transforming growth factor B1 decreases uptake of glutathione precursor amino acids in bovine pulmonary artery endothelial cells.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; Cattle; Cell Count; Cells, Cultured; Cystine; Endothelium, Vascular; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Isoxazoles; Pulmonary Artery; Transforming Growth Factor beta | 1997 |
FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts.
Topics: Alkynes; Animals; Antibody Formation; Gene Expression; Graft Rejection; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Kidney; Kidney Transplantation; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transforming Growth Factor beta; Transplantation, Homologous | 2003 |
Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Collagen Type III; Hydroxyproline; Isoxazoles; Leflunomide; Liver; Liver Cirrhosis, Experimental; Male; NF-kappa B; Nitric Oxide; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
[The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell].
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Collagen Type I; Crotonates; Hepatocytes; Hydroxybutyrates; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Kupffer Cells; Leflunomide; Male; Nitriles; Rats; Rats, Sprague-Dawley; Toluidines; Transforming Growth Factor beta | 2004 |
The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta.
Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous | 2006 |
The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression.
Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Rats; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous; Transplantation, Isogeneic | 2006 |
The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.
Topics: Alkynes; Animals; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Nitriles; Proteinuria; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Transforming Growth Factor beta; Transplantation, Homologous | 2007 |
LPA1 receptor activation promotes renal interstitial fibrosis.
Topics: Animals; Culture Media, Conditioned; Fibrosis; Humans; Isoxazoles; Kidney; Kidney Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Propionates; Receptors, Lysophosphatidic Acid; Transforming Growth Factor beta; Ureter | 2007 |
FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.
Topics: Alkynes; Animals; Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Male; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred WF; Risk Factors; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous | 2008 |
Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes.
Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Differentiation; Cells, Cultured; Crotonates; Cytokines; Drug Interactions; Estradiol; Estrogens; Humans; Hydroxybutyrates; Immunohistochemistry; Interleukin-6; Isoxazoles; Leflunomide; Macrophages; Monocytes; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Toluidines; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2010 |
Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.
Topics: Animals; Benzophenones; Bleomycin; Cells, Cultured; Collagen; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Proto-Oncogene Proteins c-fos; RNA, Small Interfering; Scleroderma, Systemic; Signal Transduction; Transcription Factor AP-1; Transfection; Transforming Growth Factor beta; Up-Regulation | 2012 |
HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors.
Topics: Animals; Benzoquinones; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Heterocyclic Compounds, 2-Ring; HSP90 Heat-Shock Proteins; Isoxazoles; Lactams, Macrocyclic; Mice; Mice, Inbred C57BL; Microphthalmia-Associated Transcription Factor; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Pyrazoles; Resorcinols; Stem Cells; Transforming Growth Factor beta; Vacuolar Proton-Translocating ATPases | 2013 |
Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice.
Topics: Animals; Cell Line; Diabetes Mellitus; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Glycogen Synthase Kinase 3 beta; Isoxazoles; Kidney Cortex; Lysophospholipids; Male; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction; Smad2 Protein; Smad3 Protein; Sterol Regulatory Element Binding Protein 1; Time Factors; Transfection; Transforming Growth Factor beta | 2017 |
Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-β and paclitaxel in A549 cells.
Topics: A549 Cells; Antigens, CD; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Plasticity; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Paclitaxel; Resorcinols; Signal Transduction; Transforming Growth Factor beta | 2020 |
(S,R)3-(4-Hydroxyphenyl)-4,5-Dihydro-5-Isoxazole Acetic Acid Methyl Ester Inhibits Epithelial-to-Mesenchymal Transition Through TGF-β/Smad4 Axis in Nasopharyngeal Carcinoma.
Topics: Acetates; Adult; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Isoxazoles; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Smad4 Protein; Squamous Cell Carcinoma of Head and Neck; Transforming Growth Factor beta | 2022 |