isoxazoles has been researched along with thiazoles in 109 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.67) | 18.7374 |
| 1990's | 16 (14.68) | 18.2507 |
| 2000's | 32 (29.36) | 29.6817 |
| 2010's | 51 (46.79) | 24.3611 |
| 2020's | 6 (5.50) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Cheng, CC; Daves, GD | 1 |
| Berlin, KD; Chesnut, RW; Durham, NN; Hashem, MM | 1 |
| Arnt, J; Lembøl, HL; Meier, E; Pedersen, H | 1 |
| Meredith, MJ | 1 |
| Fukushige, J; Ijima, Y; Koike, H; Miyamoto, M; Nakamura, N; Sada, T | 1 |
| Belliotti, TR; Boctor, AM; Connor, DT; Flynn, DL; Kostlan, CR; Nies, DE; Ortwine, DF; Schrier, DJ; Sircar, JC | 1 |
| Anderson, ME; Bridges, RJ; Meister, A; Underwood, M | 1 |
| Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Hozien, ZA | 1 |
| Anderson, DJ; Carrera, GM; Elliott, RL; Garvey, DS; He, Y; Hettinger, AM; Holladay, MW; Lebold, SA; Lin, NH; Wasicak, JT | 1 |
| Burgher, KL; Conway, PG; Hartman, HB; Hrib, NJ; Jurcak, JG; Kerman, LL; Roehr, JE; Woods, AT | 1 |
| Broom, NJ; Elder, JS; Hannan, PC; O'Hanlon, PJ; Pons, JE; Walker, G; Wilson, J; Woodall, P | 1 |
| Ballaron, SJ; Byars, N; Cherwinski, HM; Nakano, GM; Ransom, JT; Young, JM | 1 |
| Cevikbaş, A; Kömürcü, SG; Rollas, S; Yilmaz, N | 1 |
| Maggiali, CA; Mazza, P; Mingiardi, MR; Zani, F | 1 |
| Damgaard, I; Rodríguez-Farré, E; Schousboe, A; Suñol, C; Vale, C | 1 |
| Matsui, K; Nagao, K; Shibata, T; Shinkai, H; Wakitani, K; Yonemori, F | 1 |
| Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR | 1 |
| Kadowaki, T | 1 |
| Matsui, K; Shibata, T; Wakitani, K; Yonemori, F | 1 |
| Cui, D; Kamel, A; Miceli, JJ; Prakash, C; Tweedie, D; Whalen, RD | 1 |
| Kakimoto, K; Shibata, T; Takeuchi, S; Wakitani, K; Yokota, S; Yonemori, F | 1 |
| Hisatome, I; Ogino, K; Shigemasa, C; Shimoyama, M; Uchida, K | 1 |
| Miljkovic, D; Mostarica Stojkovic, M; Popadic, D; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V | 1 |
| Abe, I; Eto, K; Fujishima, M; Nakamura, Y; Ohya, Y | 1 |
| Gierse, JK; Isakson, PC; Kiefer, JR; Koboldt, CM; Kurumbail, RG; Moreland, KT; Seibert, K; Walker, MC | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Albert, MJ; Baldessarini, RJ; Centorrino, F; Kelleher, JP | 1 |
| Drakulic, D; Miljkovic, Dj; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V | 1 |
| Yamanouchi, T | 1 |
| Kalkman, HO; Loetscher, E | 1 |
| Adams, AD; Berger, JP; Doebber, TW; Hu, Z; Jones, AB; MacNaul, KL; Moller, DE; Santini, C; Yuen, W | 1 |
| Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L | 1 |
| Dahlborg, R; Day, CA; Jacob, RF; Mason, RP; Walter, MF; Weng, Y | 1 |
| Ashton, WT; Dong, H; Doss, GA; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Sisco, RM; Thornberry, NA; Weber, AE; Wu, JK | 1 |
| Feng, H; Gao, JW; Li, XY; Tang, MY; Xu, LF; Zheng, JR | 1 |
| Hashkes, PJ; Laxer, RM | 1 |
| Cashman, JR; Cerny, MA; Denton, TT; Johnson, EF; Yano, JK; Zhang, X | 1 |
| Beutel, BA; Camp, HS; Frevert, EU; Gu, YG; Keyes, RF; Li, Q; Sham, HL; Wang, R; Wang, X; Weitzberg, M; Xu, X; Zhang, X | 1 |
| Bartlett, MG; Terry, AV; Zhang, G | 1 |
| Cutler, AJ; Hamilton, J; Kalali, AH; Weiden, PJ; Wolfgang, CD | 1 |
| Hamilton, J; Heaton, C; Lannan, R; Lavedan, C; Licamele, L; Mack, K; Polymeropoulos, MH; Thompson, A; Volpi, S; Wolfgang, CD | 1 |
| Hamilton, JB; Heaton, C; Lannan, R; Lavedan, C; Licamele, L; Mack, K; Polymeropoulos, MH; Volpi, S; Wolfgang, CD | 1 |
| Bian, F; Hao, N; Zhang, M | 1 |
| Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG | 1 |
| Ghosh, S; Maity, P; Mallick, P; Roy, S | 1 |
| Hara, A; Hirose, Y; Hoshino, T; Murashita, H; Tabuchi, K; Tobita, T; Uemaetomari, I | 1 |
| Clement, HW; Heiser, P; Hemmeter, UM; Krieg, JC; Schmidt, AJ; Schulz, E; Vedder, H | 1 |
| El-Badri, MH; Kurth, MJ | 1 |
| Hu, DJ; Huang, TH; Liu, SF; Tu, HY; Zhang, AD | 1 |
| Kumar, R; Sachdev, PS | 1 |
| Lavedan, C; Licamele, L; Malhotra, AK; Potkin, SG; Volpi, S | 1 |
| Díaz, J; González, A; Mora, C; Quintana, G | 1 |
| Lavedan, C; Thompson, A; Volpi, S | 1 |
| Kumar, A; Kumar, P; Kumari, B | 1 |
| Bennett, DJ; Cooke, AJ; Fradera, X; Haunsø, A; Hosfield, D; King, A; McGuire, R; Nimz, O; Skene, R; Uitdehaag, JC; Vu, D; Wynands, R | 1 |
| Chernyak, BV; Chumakov, PM; Evstafieva, AG; Khutornenko, AA; Roudko, VV; Vartapetian, AB | 1 |
| Cho, SG; Choi, HY; Jeong, HS; Kim, JH; Lee, ER | 1 |
| Butler, JD; Coffman, KC; Kurth, MJ; Toney, MD; Ziebart, KT | 1 |
| Newman, M | 1 |
| Gupta, A; Kulkarni, SK; Kumar, A | 1 |
| Howland, RH | 1 |
| Citrome, L | 1 |
| Muralikrishna, A; Padmaja, A; Padmavathi, V; Rajasekhar, C | 1 |
| Grant, JS; Keltner, NL; Moore, RL | 1 |
| Nagi Reddy, M; Rajanarendar, E; Rama Murthy, K; Reddy, RN; Reddy, YN; Surendar, P | 1 |
| Citrome, L; Hochfeld, M; Meng, X; Stahl, SM | 1 |
| Boshoff, H; Chang, M; Cho, S; Franzblau, SG; Hwang, CH; Markley, LD; Miller, MJ; Moraski, GC | 1 |
| Dong, L; Liu, Y; Shi, J | 1 |
| Li, Z; Liu, M; Liu, T; Luo, J; Qiu, WW; Tang, J; Xu, J; Yang, F | 1 |
| Bajpai, M; Banerjee, A; Gharat, LA; Gudi, GS; Gullapalli, S; Sangana, RR; Yadav, PS | 1 |
| Stahl, SM; Tarazi, FI | 1 |
| Dadmal, TL; Janaki Ramaiah, M; Kosurkar, UB; Kumbhare, RM; Pal-Bhadra, M; Pushpavalli, SN | 1 |
| Correll, CU; De Hert, M; Detraux, J; Sweers, K; van Winkel, R; Yu, W | 1 |
| Berthelot, P; Boukhalfa, K; Caignard, DH; Delagrange, P; Ettaoussi, M; Landagaray, E; Rami, M; Yous, S | 1 |
| Bobo, WV | 1 |
| Hochfeld, M; Meng, X; Potkin, SG; Preskorn, S | 1 |
| Cutler, AJ; Kalali, AH; Kunovac, J; Mattingly, GW; Meng, X | 1 |
| Amrutheshwar, R; Dkhar, SA; George, M; Kattimani, S; Rajkumar, RP | 1 |
| Mehta, MU; Rogers, H; Uppoor, RS; Younis, IR; Zhang, H; Zhu, H | 1 |
| Kasakov, L; Kraevsky, P; Vlaskovska, M | 1 |
| Aleksic, T; Chitnis, MM; Gao, S; Lodhia, KA; Macaulay, VM; Protheroe, AS | 1 |
| Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Peeters, WJ; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Wheeler, DL | 1 |
| Dai, G; Zhang, Y | 1 |
| Larson, JL; Potter, DA; Redmond, CT | 1 |
| Brazhe, A; Jensen, K; Jessen, SB; Lauritzen, M; Lind, BL; Mathiesen, C; Thomsen, K | 1 |
| Ballazhi, L; Dräger, G; Huwiler, A; Imeri, F; Jashari, A; Mikhova, B; Popovski, E; Shabani, A | 1 |
| Anthony, J; Anupindi, R; Bhagat, PR; Bose, J; Dalal, R; Deshmukh, NJ; Dixit, A; Gupte, A; Kandre, S; Reddy, MM; Sharma, R | 1 |
| Li, Y; Liu, X; Sun, F; Teng, L; Wang, D; Zhao, J; Zhou, Y | 1 |
| Raboisson, P; Swedberg, MD | 1 |
| Morrissette, DA; Stahl, SM | 1 |
| Aleksic, T; Esashi, F; Gao, S; Lodhia, KA; Macaulay, VM | 1 |
| Geerts, H; Potkin, S; Roberts, P; Spiros, A | 1 |
| Ballazhi, L; Ibrahimi, I; Imeri, F; Jashari, A; Mikhova, B; Mladenovska, K; Popovski, E | 1 |
| Afshinjavid, S; Blackburn, J; Coles, SJ; Hemming, K; Horton, PN; Javid, FA; Molyneux, G; Page, MI; Pitard, A; Rice, CR | 1 |
| Mejia, GL; Pasteris, RJ; Pember, SO; Price, TJ | 1 |
| Nagy, PI | 1 |
| Byrappa, S; Harsha Raj, M; Kudva N, NU; Kungyal, T; Lokanatha Rai, KM; Salimath, BP | 1 |
| Auber, A; Goldberg, SR; Justinova, Z; Panlilio, LV; Redhi, GH; Schindler, CW; Schwarcz, R; Secci, ME; Thorndike, EB | 1 |
| Androphy, EJ; Boaler, PJ; Burnett, BG; Calder, AN; Cherry, JJ; Choi, S; Cuny, GD; Fritsche, M; Glicksman, MA; Hodgetts, KJ; Kern, NL; Li, H; Lorson, CL; Lusic, H; Quist, KM; Rietz, A; Xing, X | 1 |
| Azzali, E; Cabassi, CS; Costantino, G; Flisi, S; Kaushik, A; Lamichhane, G; Machado, D; Pieroni, M; Vacondio, F; Viveiros, M | 1 |
| Lee, C; Robinson, M; Willerth, SM | 1 |
| Abdo, NYM; Al-Darkazali, WN; Mohareb, RM | 1 |
| Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S | 1 |
| Bornfleth, P; Bukowska, A; Gardemann, A; Goette, A; Isermann, B; Peter, D; Schild, L; Walles, T; Wiese-Rischke, C | 1 |
| Conlon, IL; Drennen, B; Fletcher, S; Hughes, S; Lanning, ME; MacKerell, AD; Rothhaas, R; Wilder, PT | 1 |
| Rajan, R; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
| Shamili, S; Srinivas, A; Sunitha, M | 1 |
16 review(s) available for isoxazoles and thiazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
The chemistry and biochemistry of C-nucleosides.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine | 1976 |
[Insulin-sensitizing agents].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Isoxazoles; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones | 1999 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Advances in atypical antipsychotics for the treatment of schizophrenia: new formulations and new agents.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dosage Forms; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quinolones; Risperidone; Schizophrenia; Thiazoles | 2002 |
[Chemical structures and pharmacological characteristics of novel non-thiazolidinedione insulin sensitizer (JTT-501, FK614)].
Topics: Animals; Blood Glucose; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Lipid Metabolism; Oxadiazoles; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Update on the medical treatment of juvenile idiopathic arthritis.
Topics: Antibodies, Blocking; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Humans; Immunologic Factors; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Naproxen; Rheumatology; Thiazines; Thiazoles | 2006 |
Akathisia and second-generation antipsychotic drugs.
Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Prevalence; Psychomotor Agitation; Psychotic Disorders; Quetiapine Fumarate; Quinolones; Risk Factors; Risperidone; Sulpiride; Thiazoles | 2009 |
Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles | 2011 |
Iloperidone, asenapine and lurasidone: a primer on their current status.
Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles; United States; United States Food and Drug Administration | 2012 |
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
Topics: Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lipid Metabolism; Lurasidone Hydrochloride; Paliperidone Palmitate; Piperidines; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Weight Gain | 2012 |
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.
Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles | 2013 |
Newer antipsychotics and upcoming molecules for schizophrenia.
Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperazines; Piperidines; Schizophrenia; Thiazoles | 2013 |
An integrated clinical pharmacology approach for deriving dosing recommendations in a regulatory setting: review of recent cases in psychiatry drugs.
Topics: Antipsychotic Agents; Central Nervous System Stimulants; Drug Approval; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Methylphenidate; Paliperidone Palmitate; Pharmacology, Clinical; Pimozide; Pyrimidines; Thiazoles | 2013 |
Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Clozapine; Dibenzocycloheptenes; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Humans; Impulsive Behavior; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Polypharmacy; Psychotic Disorders; Quetiapine Fumarate; Receptors, Dopamine D2; Risperidone; Thiazoles; Violence | 2014 |
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
9 trial(s) available for isoxazoles and thiazoles
| Article | Year |
|---|---|
Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Schizophrenia; Thiazoles; Treatment Outcome | 2008 |
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; Double-Blind Method; Female; Genome-Wide Association Study; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Isoxazoles; Male; Middle Aged; Nerve Tissue Proteins; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Pseudogenes; Receptors, AMPA; Schizophrenia; Tenascin; Thiazoles; Transcription Factors; Young Adult | 2009 |
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Carrier Proteins; CELF Proteins; Cytoskeletal Proteins; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Linear Models; Linkage Disequilibrium; Long QT Syndrome; Male; Middle Aged; Neuregulins; Organic Anion Transporters; Pharmacogenetics; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Piperidines; Polymorphism, Single Nucleotide; RNA-Binding Proteins; Schizophrenia; Thiazoles; Young Adult | 2009 |
Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia.
Topics: Adult; Alleles; Antipsychotic Agents; Double-Blind Method; Female; Genetic Markers; Genotype; Humans; Isoxazoles; Likelihood Functions; Male; Middle Aged; Odds Ratio; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Probability; Psychiatric Status Rating Scales; Psychometrics; Schizophrenia; Thiazoles; Treatment Outcome | 2009 |
Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone.
Topics: Analysis of Variance; Antipsychotic Agents; Female; Follow-Up Studies; Gene Frequency; Genotype; Humans; Isoxazoles; Male; Piperazines; Piperidines; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Schizophrenia; Thiazoles; Weight Gain | 2010 |
Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Labeling; Female; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Thiazoles; Treatment Outcome; Young Adult | 2012 |
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult | 2013 |
Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Female; Humans; India; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Piperazines; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Thiazoles; Time Factors; Treatment Outcome; United States; Young Adult | 2013 |
Efficacy and metabolic influence of paliperidone ER, aripiprazole and ziprasidone to patients with first-episode schizophrenia through 52 weeks follow-up in China.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Body Mass Index; China; Delayed-Action Preparations; Diagnostic and Statistical Manual of Mental Disorders; Female; Follow-Up Studies; Humans; Hyperglycemia; Hyperlipidemias; Isoxazoles; Male; Metabolic Diseases; Paliperidone Palmitate; Piperazines; Psychiatric Status Rating Scales; Pyrimidines; Quinolones; Schizophrenia; Thiazoles; Weight Gain; Young Adult | 2012 |
84 other study(ies) available for isoxazoles and thiazoles
| Article | Year |
|---|---|
Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethyoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity.
Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pseudomonas fluorescens; Pyrazoles; Spectrophotometry, Infrared; Staphylococcus aureus; Steroids, Heterocyclic; Thiazoles | 1976 |
Discriminative stimulus properties of the muscarinic receptor agonists Lu 26-046 and O-Me-THPO in rats: evidence for involvement of different muscarinic receptor subtypes.
Topics: Animals; Discrimination Learning; Guinea Pigs; Ileum; In Vitro Techniques; Isoxazoles; Male; Parasympathomimetics; Pyridines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Muscarinic; Scopolamine; Stereoisomerism; Thiazoles | 1992 |
Glutathione and glutathione conjugate efflux from cultured liver cells.
Topics: Animals; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Ethacrynic Acid; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Isoxazoles; Liver; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1991 |
The effects of R-75,317 on antiglomerular basement membrane glomerulonephritis in rats.
Topics: Acetylglucosaminidase; Animals; Basement Membrane; Biomarkers; Blood Pressure; Creatinine; Female; Glomerulonephritis; Immune Sera; Isoxazoles; Kidney; Kidney Glomerulus; Platelet Activating Factor; Proteinuria; Rats; Rats, Inbred Strains; Thiazoles | 1991 |
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles | 1991 |
Glutathione metabolism at the blood-cerebrospinal fluid barrier.
Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1986 |
Synthesis of some new heterocyclic systems derived from 2-acetylbenzimidazole.
Topics: Azoles; Benzimidazoles; Heterocyclic Compounds; Isoxazoles; Microbial Sensitivity Tests; Organoselenium Compounds; Pyrazoles; Thiazoles | 1993 |
Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine.
Topics: Animals; Brain; Dopamine; Isoxazoles; Ligands; Nicotinic Agonists; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Thiazoles | 1994 |
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Isoxazoles; Male; Mice; Rats; Rats, Wistar; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1994 |
The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.
Topics: Animals; Anti-Bacterial Agents; Furans; Humans; Isoxazoles; Mice; Mupirocin; Oxazoles; Pyrazoles; Pyridines; Sepsis; Staphylococcal Infections; Thiazoles; Thiophenes | 1995 |
Leflunomide interferes with pyrimidine nucleotide biosynthesis.
Topics: Animals; Concanavalin A; Female; Humans; Immunosuppressive Agents; In Vitro Techniques; Indicators and Reagents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; PC12 Cells; Pyrimidine Nucleotides; Rats; Spleen; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1995 |
Synthesis of 3-methyl-4-[(2,4-dihydro-4-substituted-3H-1,2,4-triazole-3-thione-5-yl) phenylhydrazono]-5-isoxazolone and evaluation of their antimicrobial activities.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Bacteria; Fungi; Isoxazoles; Mass Spectrometry; Microbial Sensitivity Tests; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles | 1995 |
Biological studies on 1,2-benzisothiazole derivatives VI Antimicrobial activity of 1,2-benzisothiazole and 1,2-benzisothiazolin-3-one derivatives and of some corresponding 1,2-benzisoxazoles.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Fungi; Isoxazoles; Structure-Activity Relationship; Thiazoles | 1996 |
Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hexachlorocyclohexane; Insecticides; Isoxazoles; Mice; Mitochondria; Neurons; Synaptic Transmission; Tetrazolium Salts; Thiazoles | 1998 |
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
Topics: 3T3 Cells; Administration, Oral; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pioglitazone; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1999 |
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction | 1999 |
Triglyceride-lowering effect of a novel insulin-sensitizing agent, JTT-501.
Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Isoxazoles; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides | 1999 |
Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions.
Topics: Antipsychotic Agents; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Isoxazoles; Liver; Microsomes, Liver; Paliperidone Palmitate; Piperazines; Pyrimidines; Risperidone; Sulfones; Sulfoxides; Thiazoles | 2000 |
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats.
Topics: Absorptiometry, Photon; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Cataract; Chromans; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Eating; Hypoglycemic Agents; Isoxazoles; Male; Neural Conduction; Obesity; Pancreas; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone | 2000 |
Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts.
Topics: Animals; Chromans; Dose-Response Relationship, Drug; Hemodynamics; Hypoglycemic Agents; Indomethacin; Isoxazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Pioglitazone; Prostaglandins; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2000 |
Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes.
Topics: Animals; Astrocytes; Astrocytoma; Cell Line; Enzyme Activation; Immunosuppressive Agents; Indicators and Reagents; Interferon-gamma; Isoxazoles; Leflunomide; Lipopolysaccharides; Mitogen-Activated Protein Kinase Kinases; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein-Tyrosine Kinases; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2001 |
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Isoxazoles; Kinetics; Meloxicam; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sheep; Sulfonamides; Thiazines; Thiazoles | 2001 |
Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms.
Topics: Aniline Compounds; Animals; Cell Line; Cell Survival; Cells, Cultured; Coloring Agents; Crotonates; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Guanidines; Humans; Hydroxybutyrates; Immunosuppressive Agents; Interferon-gamma; Interleukin-6; Isoxazoles; Leflunomide; Macrophages; Mice; Mycophenolic Acid; Nitric Oxide Synthase; Nitriles; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Rolipram; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines | 2002 |
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine | 2003 |
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
Topics: Administration, Oral; Animals; Biological Availability; COS Cells; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Isoxazoles; Mice; Mice, Mutant Strains; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles | 2005 |
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.
Topics: Animals; Antioxidants; Celecoxib; Cholesterol, LDL; Chromans; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Isoprostanes; Isoxazoles; Lactones; Meloxicam; Naproxen; Oxidation-Reduction; Pyrazoles; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2004 |
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles | 2005 |
Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.
Topics: Anthralin; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Proliferation; Cells, Cultured; Diterpenes; Enzyme Inhibitors; Epoxy Compounds; Humans; I-kappa B Proteins; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-8; Isoxazoles; Keratinocytes; Leflunomide; NF-kappa B; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles | 2005 |
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.
Topics: Acetylene; Animals; Aryl Hydrocarbon Hydroxylases; Crystallography, X-Ray; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Furans; Humans; Imidazoles; In Vitro Techniques; Isoxazoles; Mice; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Nicotine; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiazoles; Thiophenes; Time Factors | 2006 |
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
Topics: Acetyl-CoA Carboxylase; Alkynes; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydroxyurea; Isoxazoles; Molecular Conformation; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2007 |
Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chromatography, Liquid; Clozapine; Haloperidol; Isoxazoles; Male; Olanzapine; Paliperidone Palmitate; Piperazines; Pyrimidines; Rats; Reproducibility of Results; Risperidone; Tandem Mass Spectrometry; Thiazoles | 2007 |
The active metabolite of leflunomide A771726 inhibits corneal neovascularization.
Topics: Aniline Compounds; Animals; Cell Nucleus; Cell Proliferation; Corneal Neovascularization; Crotonates; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines; Umbilical Veins | 2008 |
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles | 2009 |
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Female; Glutaminase; Glutamine; Humans; In Vitro Techniques; Isoxazoles; Laminin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor A | 2008 |
The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Auditory Threshold; Cochlea; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Indomethacin; Isoxazoles; Lipoxygenase Inhibitors; Masoprocol; Meloxicam; Mice; Mice, Inbred Strains; Neuroprotective Agents; Pyrazoles; Sulfones; Thiazines; Thiazoles | 2008 |
Effects of quetiapine, risperidone, 9-hydroxyrisperidone and ziprasidone on the survival of human neuronal and immune cells in vitro.
Topics: Adenosine Triphosphate; Antipsychotic Agents; Cell Line; Cell Survival; Dibenzothiazepines; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Isoxazoles; Monocytes; Neurons; Paliperidone Palmitate; Piperazines; Pyrimidines; Quetiapine Fumarate; Risperidone; Thiazoles | 2010 |
Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles.
Topics: Benzene Derivatives; Cyclization; Halogenation; Isoxazoles; Molecular Structure; Thiazoles | 2009 |
Synthesis and herbicidal activities of novel 4-(4-(5-methyl-3-arylisoxazol-4-yl)thiazol-2-yl)piperidyl carboxamides and thiocarboxamides.
Topics: Binding, Competitive; Computer Simulation; Herbicides; Isoxazoles; Models, Molecular; Piperidines; Plant Proteins; Protease Inhibitors; Spinacia oleracea; Thiazoles | 2009 |
[Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Colombia; Diagnostic Services; Direct Service Costs; Disease Management; Drug Costs; Drug Therapy, Combination; Etanercept; Health Care Costs; Hospital Costs; Hospitals, University; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Thiazines; Thiazoles | 2009 |
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Isoxazoles; Lactones; Lipid Peroxidation; Male; Meloxicam; Memory; Mice; Motor Activity; Naproxen; Nitrites; Random Allocation; Stress, Psychological; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2010 |
X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
Topics: Benzoates; Benzylamines; Binding Sites; Crystallography, X-Ray; Dimerization; Isoxazoles; Ligands; Liver X Receptors; Models, Molecular; Orphan Nuclear Receptors; Phenylacetates; Sequence Alignment; Signal Transduction; Thiazoles | 2010 |
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Respiration; Dihydroorotate Dehydrogenase; Electron Transport Complex III; Humans; Isoxazoles; Leflunomide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases Acting on CH-CH Group Donors; Potassium Cyanide; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrimidines; Quinone Reductases; Reactive Oxygen Species; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma in Situ; Cell Death; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Piperazines; Sulfonamides; Thiazoles | 2010 |
Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.
Topics: Amino Acids, Diamino; Anthranilate Synthase; Intramolecular Transferases; Isoxazoles; Stereoisomerism; Thiazoles | 2010 |
Bitter pills for drug companies.
Topics: Acetamides; Drug Approval; Drug Industry; Fraud; gamma-Aminobutyric Acid; Isoxazoles; Linezolid; Motivation; Off-Label Use; Oxazolidinones; Piperazines; Pregabalin; Sulfonamides; Thiazoles; United States | 2010 |
Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Catatonia; Cyclooxygenase 2 Inhibitors; Inflammation; Isoxazoles; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mitochondria; Motor Activity; MPTP Poisoning; NADH Dehydrogenase; Neuroprotective Agents; Nitrites; Nitrobenzenes; Oxidative Stress; Signal Transduction; Sulfhydryl Compounds; Sulfonamides; Tetrazolium Salts; Thiazoles; Thiobarbituric Acid Reactive Substances; Transcription Factor RelA | 2011 |
Update on newer antipsychotic drugs.
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Pregnancy; Schizophrenia; Thiazoles; Treatment Outcome | 2011 |
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
Topics: Antioxidants; Biphenyl Compounds; Free Radicals; Isoxazoles; Nitric Oxide; Oxazoles; Picrates; Pyrazoles; Thiazoles | 2011 |
Biological perspectives: update on newer antipsychotic drugs: are they evidence based?
Topics: Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Dibenzocycloheptenes; Evidence-Based Medicine; Heterocyclic Compounds, 4 or More Rings; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoindoles; Isoxazoles; Lactones; Lurasidone Hydrochloride; Piperidines; Psychotic Disorders; Pyridines; Serotonin Receptor Agonists; Sulfones; Thiazoles | 2011 |
Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Line, Tumor; Chemistry, Pharmaceutical; Cisplatin; Drug Design; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Inhibitory Concentration 50; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Mice; Models, Chemical; Neoplasms; Spectrophotometry, Infrared; Tetrazolium Salts; Thiazoles | 2012 |
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.
Topics: Antitubercular Agents; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Pyridines; Structure-Activity Relationship; Thiazoles | 2012 |
Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.
Topics: Antitubercular Agents; Bacterial Proteins; Biphenyl Compounds; Catalytic Domain; Hydrogen Bonding; Isoxazoles; Molecular Dynamics Simulation; Phosphorous Acids; Protein Binding; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Thermodynamics; Thiazoles | 2012 |
Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.
Topics: Acid Phosphatase; Animals; Betulinic Acid; Bone Density Conservation Agents; Bone Resorption; Cathepsin K; Cell Differentiation; Cell Line; Cell Proliferation; Crystallography, X-Ray; Female; Isoenzymes; Isoxazoles; Mice; Mice, Inbred C57BL; Osteoclasts; Ovariectomy; Pentacyclic Triterpenes; Pyrazines; Pyrazoles; Pyrimidines; RANK Ligand; Rats; Structure-Activity Relationship; Tartrate-Resistant Acid Phosphatase; Thiazoles; Triterpenes | 2012 |
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
Topics: Central Nervous System; Cyclic Nucleotide Phosphodiesterases, Type 7; Humans; Isoxazoles; Parkinson Disease; Pharmacokinetics; Phosphodiesterase Inhibitors; Pyrimidinones; Structure-Activity Relationship; Thiazoles | 2012 |
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles | 2012 |
Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands.
Topics: Acetamides; Animals; CHO Cells; Cricetinae; Isoxazoles; Ligands; Oxazolidinones; Pyrrolidinones; Radioligand Assay; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Structure-Activity Relationship; Tetrazoles; Thiazoles | 2012 |
Dynamics of Parecoxib or Meloxicam effect on acute postoperative pain after orthopedic surgical interventions: comparative study in hospitalized women and men.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesics; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Meloxicam; Middle Aged; Orthopedic Procedures; Pain, Postoperative; Thiazines; Thiazoles; Young Adult | 2011 |
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Fibroblasts; HEK293 Cells; Histones; Homologous Recombination; Humans; Isoxazoles; Mice, Knockout; Morpholines; Pyrimidines; Pyrones; Quinolines; Radiation Tolerance; Receptor, IGF Type 1; Recombinational DNA Repair; Thiazoles | 2014 |
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
Topics: Antineoplastic Agents; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dasatinib; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Imidazoles; Isoxazoles; Leflunomide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Radiation Tolerance; STAT5 Transcription Factor; STAT6 Transcription Factor; Thiazoles; Tumor Suppressor Proteins | 2013 |
Impacts of a neonicotinoid, neonicotinoid-pyrethroid premix, and anthranilic diamide insecticide on four species of turf-inhabiting beneficial insects.
Topics: Animals; Bees; Coleoptera; Diamide; Guanidines; Hymenoptera; Insecticides; Isoxazoles; Neonicotinoids; ortho-Aminobenzoates; Plant Weeds; Pyrethrins; Thiazoles | 2014 |
GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo.
Topics: Action Potentials; Animals; Biophysics; Calcium; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Functional Laterality; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Oxygen Consumption; Partial Pressure; Pyridines; Receptors, GABA-A; Somatosensory Cortex; Sulfonamides; Thiazoles; Vibrissae; Zolpidem | 2015 |
Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinylidene-chroman-2,4-diones on cancer and non-cancer cell growth and death.
Topics: 4-Hydroxycoumarins; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Coumarins; Humans; Isoxazoles; MCF-7 Cells; Poly(ADP-ribose) Polymerases; Thiazoles; U937 Cells | 2014 |
Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.
Topics: Animals; Carboxylic Acids; Cyclohexanes; Diacylglycerol O-Acyltransferase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoxazoles; Mice; Mice, Knockout; Molecular Conformation; Structure-Activity Relationship; Thiazoles | 2014 |
Parenteral thermo-sensitive organogel for schizophrenia therapy, in vitro and in vivo evaluation.
Topics: Animals; Antipsychotic Agents; Coumarins; Drug Delivery Systems; Fatty Acids; Gels; Isoxazoles; Male; Mice, Nude; Paliperidone Palmitate; Phase Transition; Pyrimidines; Rats, Sprague-Dawley; Schizophrenia; Soybean Oil; Thiazoles; Transition Temperature; Viscosity | 2014 |
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles | 2014 |
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
Topics: Blotting, Western; Boron Compounds; BRCA1 Protein; BRCA2 Protein; CDC2 Protein Kinase; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Repair; Histones; Homologous Recombination; Humans; Isoxazoles; Male; Microscopy, Fluorescence; Phosphorylation; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Quinolines; Rad51 Recombinase; Receptor, IGF Type 1; RNA Interference; Thiazoles | 2015 |
Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: application to iloperidone.
Topics: Antipsychotic Agents; Computer Simulation; Genotype; Humans; Isoxazoles; Models, Biological; Molecular Targeted Therapy; Neurobiology; Pharmacogenetics; Piperazines; Piperidines; Schizophrenia; Thiazoles | 2015 |
Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases.
Topics: 4-Hydroxycoumarins; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Isoxazoles; Lung Neoplasms; Thiazoles; Time Factors | 2015 |
Synthesis, conformation and antiproliferative activity of isothiazoloisoxazole 1,1-dioxides.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; MCF-7 Cells; Molecular Conformation; Structure-Activity Relationship; Thiazoles | 2016 |
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.
Topics: Amidohydrolases; Analgesics; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Pain; Pain Measurement; Piperidines; Structure-Activity Relationship; Thiazoles | 2016 |
Replacement of Oxygen by Sulfur in Small Organic Molecules. 3. Theoretical Studies on the Tautomeric Equilibria of the 2OH and 4OH-Substituted Oxazole and Thiazole and the 3OH and 4OH-Substituted Isoxazole and Isothiazole in the Isolated State and in Solu
Topics: Isomerism; Isoxazoles; Models, Theoretical; Oxazoles; Solutions; Sulfur; Thermodynamics; Thiazoles | 2016 |
Synthesis and biological evaluation of novel isoxazolines linked via piperazine to 2- benzoisothiazoles as potent apoptotic agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Design; Humans; Isoxazoles; Piperazines; Thiazoles; Time Factors | 2017 |
Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys.
Topics: Animals; Cocaine; Dopamine; Isoxazoles; Kynurenic Acid; Male; Nicotine; Nucleus Accumbens; Phenylurea Compounds; Rats; Recurrence; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Sulfonamides; Thiazoles | 2017 |
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
Topics: Anilides; Area Under Curve; Benzamides; Cell Line; Drug Discovery; Half-Life; Humans; Isoxazoles; Molecular Probes; Muscular Atrophy, Spinal; Protein Processing, Post-Translational; Protein Stability; Quinolones; Structure-Activity Relationship; Survival of Motor Neuron 1 Protein; Thiazoles | 2017 |
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Design; Drug Resistance, Multiple, Bacterial; Drug Stability; Ethidium; Humans; Isoxazoles; Macrophages; Membrane Transport Proteins; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium tuberculosis; Thiazoles; Thioridazine; Verapamil | 2017 |
Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules.
Topics: Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cellular Reprogramming; Cellular Reprogramming Techniques; Colforsin; Diamines; Glioblastoma; Heterocyclic Compounds, 4 or More Rings; Homeodomain Proteins; Humans; Isoxazoles; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; POU Domain Factors; Pyridines; Pyrimidines; Thiazoles; Thiophenes; Up-Regulation | 2018 |
Heterocyclization of 2-Arylidenecyclohexan-1,3-dione: Synthesis of Thiophene, Thiazole, and Isoxazole Derivatives with Potential Antitumor Activities.
Topics: Acetates; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclization; Cyclohexanones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Molecular Structure; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-pim-1; src-Family Kinases; Structure-Activity Relationship; Thiazoles; Thiophenes | 2020 |
Activated clotting factor X mediates mitochondrial alterations and inflammatory responses via protease-activated receptor signaling in alveolar epithelial cells.
Topics: Apoptosis; Cell Line, Tumor; Dipeptides; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Factor Xa; Factor Xa Inhibitors; Humans; Inflammation; Isoxazoles; Mitochondria; Pyridines; Receptors, Proteinase-Activated; Signal Transduction; Thiazoles | 2020 |
Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Design; Humans; Isoxazoles; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Protein Binding; Protein Conformation, alpha-Helical; Proto-Oncogene Proteins c-mdm2; Pyrazoles; Structure-Activity Relationship; Thiazoles | 2020 |
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.
Topics: Allosteric Site; Animals; Electrons; Electrophysiological Phenomena; Humans; Isoxazoles; Ligands; Oocytes; Oxazoles; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides; Thiazoles; Xenopus laevis | 2021 |
Synthesis and Biological Evaluation of Novel Pyrane Glycosides.
Topics: Anti-Bacterial Agents; Antifungal Agents; Aspergillus niger; Bacteria; Candida albicans; Glycosides; Isoxazoles; Microbial Sensitivity Tests; Pyrans; Pyrazoles; Thiazoles | 2020 |