Page last updated: 2024-08-21

isoxazoles and thiazoles

isoxazoles has been researched along with thiazoles in 109 studies

Research

Studies (109)

TimeframeStudies, this research(%)All Research%
pre-19904 (3.67)18.7374
1990's16 (14.68)18.2507
2000's32 (29.36)29.6817
2010's51 (46.79)24.3611
2020's6 (5.50)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Cheng, CC; Daves, GD1
Berlin, KD; Chesnut, RW; Durham, NN; Hashem, MM1
Arnt, J; Lembøl, HL; Meier, E; Pedersen, H1
Meredith, MJ1
Fukushige, J; Ijima, Y; Koike, H; Miyamoto, M; Nakamura, N; Sada, T1
Belliotti, TR; Boctor, AM; Connor, DT; Flynn, DL; Kostlan, CR; Nies, DE; Ortwine, DF; Schrier, DJ; Sircar, JC1
Anderson, ME; Bridges, RJ; Meister, A; Underwood, M1
Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP1
Hozien, ZA1
Anderson, DJ; Carrera, GM; Elliott, RL; Garvey, DS; He, Y; Hettinger, AM; Holladay, MW; Lebold, SA; Lin, NH; Wasicak, JT1
Burgher, KL; Conway, PG; Hartman, HB; Hrib, NJ; Jurcak, JG; Kerman, LL; Roehr, JE; Woods, AT1
Broom, NJ; Elder, JS; Hannan, PC; O'Hanlon, PJ; Pons, JE; Walker, G; Wilson, J; Woodall, P1
Ballaron, SJ; Byars, N; Cherwinski, HM; Nakano, GM; Ransom, JT; Young, JM1
Cevikbaş, A; Kömürcü, SG; Rollas, S; Yilmaz, N1
Maggiali, CA; Mazza, P; Mingiardi, MR; Zani, F1
Damgaard, I; Rodríguez-Farré, E; Schousboe, A; Suñol, C; Vale, C1
Matsui, K; Nagao, K; Shibata, T; Shinkai, H; Wakitani, K; Yonemori, F1
Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR1
Kadowaki, T1
Matsui, K; Shibata, T; Wakitani, K; Yonemori, F1
Cui, D; Kamel, A; Miceli, JJ; Prakash, C; Tweedie, D; Whalen, RD1
Kakimoto, K; Shibata, T; Takeuchi, S; Wakitani, K; Yokota, S; Yonemori, F1
Hisatome, I; Ogino, K; Shigemasa, C; Shimoyama, M; Uchida, K1
Miljkovic, D; Mostarica Stojkovic, M; Popadic, D; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V1
Abe, I; Eto, K; Fujishima, M; Nakamura, Y; Ohya, Y1
Gierse, JK; Isakson, PC; Kiefer, JR; Koboldt, CM; Kurumbail, RG; Moreland, KT; Seibert, K; Walker, MC1
Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS1
Albert, MJ; Baldessarini, RJ; Centorrino, F; Kelleher, JP1
Drakulic, D; Miljkovic, Dj; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V1
Yamanouchi, T1
Kalkman, HO; Loetscher, E1
Adams, AD; Berger, JP; Doebber, TW; Hu, Z; Jones, AB; MacNaul, KL; Moller, DE; Santini, C; Yuen, W1
Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L1
Dahlborg, R; Day, CA; Jacob, RF; Mason, RP; Walter, MF; Weng, Y1
Ashton, WT; Dong, H; Doss, GA; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Sisco, RM; Thornberry, NA; Weber, AE; Wu, JK1
Feng, H; Gao, JW; Li, XY; Tang, MY; Xu, LF; Zheng, JR1
Hashkes, PJ; Laxer, RM1
Cashman, JR; Cerny, MA; Denton, TT; Johnson, EF; Yano, JK; Zhang, X1
Beutel, BA; Camp, HS; Frevert, EU; Gu, YG; Keyes, RF; Li, Q; Sham, HL; Wang, R; Wang, X; Weitzberg, M; Xu, X; Zhang, X1
Bartlett, MG; Terry, AV; Zhang, G1
Cutler, AJ; Hamilton, J; Kalali, AH; Weiden, PJ; Wolfgang, CD1
Hamilton, J; Heaton, C; Lannan, R; Lavedan, C; Licamele, L; Mack, K; Polymeropoulos, MH; Thompson, A; Volpi, S; Wolfgang, CD1
Hamilton, JB; Heaton, C; Lannan, R; Lavedan, C; Licamele, L; Mack, K; Polymeropoulos, MH; Volpi, S; Wolfgang, CD1
Bian, F; Hao, N; Zhang, M1
Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG1
Ghosh, S; Maity, P; Mallick, P; Roy, S1
Hara, A; Hirose, Y; Hoshino, T; Murashita, H; Tabuchi, K; Tobita, T; Uemaetomari, I1
Clement, HW; Heiser, P; Hemmeter, UM; Krieg, JC; Schmidt, AJ; Schulz, E; Vedder, H1
El-Badri, MH; Kurth, MJ1
Hu, DJ; Huang, TH; Liu, SF; Tu, HY; Zhang, AD1
Kumar, R; Sachdev, PS1
Lavedan, C; Licamele, L; Malhotra, AK; Potkin, SG; Volpi, S1
Díaz, J; González, A; Mora, C; Quintana, G1
Lavedan, C; Thompson, A; Volpi, S1
Kumar, A; Kumar, P; Kumari, B1
Bennett, DJ; Cooke, AJ; Fradera, X; Haunsø, A; Hosfield, D; King, A; McGuire, R; Nimz, O; Skene, R; Uitdehaag, JC; Vu, D; Wynands, R1
Chernyak, BV; Chumakov, PM; Evstafieva, AG; Khutornenko, AA; Roudko, VV; Vartapetian, AB1
Cho, SG; Choi, HY; Jeong, HS; Kim, JH; Lee, ER1
Butler, JD; Coffman, KC; Kurth, MJ; Toney, MD; Ziebart, KT1
Newman, M1
Gupta, A; Kulkarni, SK; Kumar, A1
Howland, RH1
Citrome, L1
Muralikrishna, A; Padmaja, A; Padmavathi, V; Rajasekhar, C1
Grant, JS; Keltner, NL; Moore, RL1
Nagi Reddy, M; Rajanarendar, E; Rama Murthy, K; Reddy, RN; Reddy, YN; Surendar, P1
Citrome, L; Hochfeld, M; Meng, X; Stahl, SM1
Boshoff, H; Chang, M; Cho, S; Franzblau, SG; Hwang, CH; Markley, LD; Miller, MJ; Moraski, GC1
Dong, L; Liu, Y; Shi, J1
Li, Z; Liu, M; Liu, T; Luo, J; Qiu, WW; Tang, J; Xu, J; Yang, F1
Bajpai, M; Banerjee, A; Gharat, LA; Gudi, GS; Gullapalli, S; Sangana, RR; Yadav, PS1
Stahl, SM; Tarazi, FI1
Dadmal, TL; Janaki Ramaiah, M; Kosurkar, UB; Kumbhare, RM; Pal-Bhadra, M; Pushpavalli, SN1
Correll, CU; De Hert, M; Detraux, J; Sweers, K; van Winkel, R; Yu, W1
Berthelot, P; Boukhalfa, K; Caignard, DH; Delagrange, P; Ettaoussi, M; Landagaray, E; Rami, M; Yous, S1
Bobo, WV1
Hochfeld, M; Meng, X; Potkin, SG; Preskorn, S1
Cutler, AJ; Kalali, AH; Kunovac, J; Mattingly, GW; Meng, X1
Amrutheshwar, R; Dkhar, SA; George, M; Kattimani, S; Rajkumar, RP1
Mehta, MU; Rogers, H; Uppoor, RS; Younis, IR; Zhang, H; Zhu, H1
Kasakov, L; Kraevsky, P; Vlaskovska, M1
Aleksic, T; Chitnis, MM; Gao, S; Lodhia, KA; Macaulay, VM; Protheroe, AS1
Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Peeters, WJ; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Wheeler, DL1
Dai, G; Zhang, Y1
Larson, JL; Potter, DA; Redmond, CT1
Brazhe, A; Jensen, K; Jessen, SB; Lauritzen, M; Lind, BL; Mathiesen, C; Thomsen, K1
Ballazhi, L; Dräger, G; Huwiler, A; Imeri, F; Jashari, A; Mikhova, B; Popovski, E; Shabani, A1
Anthony, J; Anupindi, R; Bhagat, PR; Bose, J; Dalal, R; Deshmukh, NJ; Dixit, A; Gupte, A; Kandre, S; Reddy, MM; Sharma, R1
Li, Y; Liu, X; Sun, F; Teng, L; Wang, D; Zhao, J; Zhou, Y1
Raboisson, P; Swedberg, MD1
Morrissette, DA; Stahl, SM1
Aleksic, T; Esashi, F; Gao, S; Lodhia, KA; Macaulay, VM1
Geerts, H; Potkin, S; Roberts, P; Spiros, A1
Ballazhi, L; Ibrahimi, I; Imeri, F; Jashari, A; Mikhova, B; Mladenovska, K; Popovski, E1
Afshinjavid, S; Blackburn, J; Coles, SJ; Hemming, K; Horton, PN; Javid, FA; Molyneux, G; Page, MI; Pitard, A; Rice, CR1
Mejia, GL; Pasteris, RJ; Pember, SO; Price, TJ1
Nagy, PI1
Byrappa, S; Harsha Raj, M; Kudva N, NU; Kungyal, T; Lokanatha Rai, KM; Salimath, BP1
Auber, A; Goldberg, SR; Justinova, Z; Panlilio, LV; Redhi, GH; Schindler, CW; Schwarcz, R; Secci, ME; Thorndike, EB1
Androphy, EJ; Boaler, PJ; Burnett, BG; Calder, AN; Cherry, JJ; Choi, S; Cuny, GD; Fritsche, M; Glicksman, MA; Hodgetts, KJ; Kern, NL; Li, H; Lorson, CL; Lusic, H; Quist, KM; Rietz, A; Xing, X1
Azzali, E; Cabassi, CS; Costantino, G; Flisi, S; Kaushik, A; Lamichhane, G; Machado, D; Pieroni, M; Vacondio, F; Viveiros, M1
Lee, C; Robinson, M; Willerth, SM1
Abdo, NYM; Al-Darkazali, WN; Mohareb, RM1
Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S1
Bornfleth, P; Bukowska, A; Gardemann, A; Goette, A; Isermann, B; Peter, D; Schild, L; Walles, T; Wiese-Rischke, C1
Conlon, IL; Drennen, B; Fletcher, S; Hughes, S; Lanning, ME; MacKerell, AD; Rothhaas, R; Wilder, PT1
Rajan, R; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B1
Shamili, S; Srinivas, A; Sunitha, M1

Reviews

16 review(s) available for isoxazoles and thiazoles

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
The chemistry and biochemistry of C-nucleosides.
    Progress in medicinal chemistry, 1976, Volume: 13

    Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine

1976
[Insulin-sensitizing agents].
    Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:3

    Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Isoxazoles; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones

1999
Biotransformation reactions of five-membered aromatic heterocyclic rings.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics

2002
Advances in atypical antipsychotics for the treatment of schizophrenia: new formulations and new agents.
    CNS drugs, 2002, Volume: 16, Issue:4

    Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dosage Forms; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quinolones; Risperidone; Schizophrenia; Thiazoles

2002
[Chemical structures and pharmacological characteristics of novel non-thiazolidinedione insulin sensitizer (JTT-501, FK614)].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9

    Topics: Animals; Blood Glucose; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Lipid Metabolism; Oxadiazoles; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors

2002
Update on the medical treatment of juvenile idiopathic arthritis.
    Current rheumatology reports, 2006, Volume: 8, Issue:6

    Topics: Antibodies, Blocking; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Humans; Immunologic Factors; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Naproxen; Rheumatology; Thiazines; Thiazoles

2006
Akathisia and second-generation antipsychotic drugs.
    Current opinion in psychiatry, 2009, Volume: 22, Issue:3

    Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Prevalence; Psychomotor Agitation; Psychotic Disorders; Quetiapine Fumarate; Quinolones; Risk Factors; Risperidone; Sulpiride; Thiazoles

2009
Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.
    Postgraduate medicine, 2011, Volume: 123, Issue:2

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles

2011
Iloperidone, asenapine and lurasidone: a primer on their current status.
    Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:13

    Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles; United States; United States Food and Drug Administration

2012
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
    CNS drugs, 2012, Sep-01, Volume: 26, Issue:9

    Topics: Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lipid Metabolism; Lurasidone Hydrochloride; Paliperidone Palmitate; Piperidines; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Weight Gain

2012
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.
    Expert review of clinical pharmacology, 2013, Volume: 6, Issue:1

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles

2013
Newer antipsychotics and upcoming molecules for schizophrenia.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:8

    Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperazines; Piperidines; Schizophrenia; Thiazoles

2013
An integrated clinical pharmacology approach for deriving dosing recommendations in a regulatory setting: review of recent cases in psychiatry drugs.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:10

    Topics: Antipsychotic Agents; Central Nervous System Stimulants; Drug Approval; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Methylphenidate; Paliperidone Palmitate; Pharmacology, Clinical; Pimozide; Pyrimidines; Thiazoles

2013
Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy.
    CNS spectrums, 2014, Volume: 19, Issue:5

    Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Clozapine; Dibenzocycloheptenes; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Humans; Impulsive Behavior; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Polypharmacy; Psychotic Disorders; Quetiapine Fumarate; Receptors, Dopamine D2; Risperidone; Thiazoles; Violence

2014
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
    The American journal of psychiatry, 2020, 04-01, Volume: 177, Issue:4

    Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes

2020

Trials

9 trial(s) available for isoxazoles and thiazoles

ArticleYear
Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2 Suppl 1

    Topics: Acute Disease; Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Schizophrenia; Thiazoles; Treatment Outcome

2008
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.
    Molecular psychiatry, 2009, Volume: 14, Issue:8

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; Double-Blind Method; Female; Genome-Wide Association Study; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Isoxazoles; Male; Middle Aged; Nerve Tissue Proteins; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Pseudogenes; Receptors, AMPA; Schizophrenia; Tenascin; Thiazoles; Transcription Factors; Young Adult

2009
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
    Molecular psychiatry, 2009, Volume: 14, Issue:11

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Carrier Proteins; CELF Proteins; Cytoskeletal Proteins; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Linear Models; Linkage Disequilibrium; Long QT Syndrome; Male; Middle Aged; Neuregulins; Organic Anion Transporters; Pharmacogenetics; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Piperidines; Polymorphism, Single Nucleotide; RNA-Binding Proteins; Schizophrenia; Thiazoles; Young Adult

2009
Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia.
    The Journal of clinical psychiatry, 2009, Volume: 70, Issue:6

    Topics: Adult; Alleles; Antipsychotic Agents; Double-Blind Method; Female; Genetic Markers; Genotype; Humans; Isoxazoles; Likelihood Functions; Male; Middle Aged; Odds Ratio; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Probability; Psychiatric Status Rating Scales; Psychometrics; Schizophrenia; Thiazoles; Treatment Outcome

2009
Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone.
    Psychiatry research, 2010, Feb-28, Volume: 175, Issue:3

    Topics: Analysis of Variance; Antipsychotic Agents; Female; Follow-Up Studies; Gene Frequency; Genotype; Humans; Isoxazoles; Male; Piperazines; Piperidines; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Schizophrenia; Thiazoles; Weight Gain

2010
Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials.
    Human psychopharmacology, 2012, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Labeling; Female; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Thiazoles; Treatment Outcome; Young Adult

2012
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult

2013
Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial.
    CNS spectrums, 2013, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Female; Humans; India; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Piperazines; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Thiazoles; Time Factors; Treatment Outcome; United States; Young Adult

2013
Efficacy and metabolic influence of paliperidone ER, aripiprazole and ziprasidone to patients with first-episode schizophrenia through 52 weeks follow-up in China.
    Human psychopharmacology, 2012, Volume: 27, Issue:6

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Body Mass Index; China; Delayed-Action Preparations; Diagnostic and Statistical Manual of Mental Disorders; Female; Follow-Up Studies; Humans; Hyperglycemia; Hyperlipidemias; Isoxazoles; Male; Metabolic Diseases; Paliperidone Palmitate; Piperazines; Psychiatric Status Rating Scales; Pyrimidines; Quinolones; Schizophrenia; Thiazoles; Weight Gain; Young Adult

2012

Other Studies

84 other study(ies) available for isoxazoles and thiazoles

ArticleYear
Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethyoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:2

    Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pseudomonas fluorescens; Pyrazoles; Spectrophotometry, Infrared; Staphylococcus aureus; Steroids, Heterocyclic; Thiazoles

1976
Discriminative stimulus properties of the muscarinic receptor agonists Lu 26-046 and O-Me-THPO in rats: evidence for involvement of different muscarinic receptor subtypes.
    European journal of pharmacology, 1992, Jul-21, Volume: 218, Issue:1

    Topics: Animals; Discrimination Learning; Guinea Pigs; Ileum; In Vitro Techniques; Isoxazoles; Male; Parasympathomimetics; Pyridines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Muscarinic; Scopolamine; Stereoisomerism; Thiazoles

1992
Glutathione and glutathione conjugate efflux from cultured liver cells.
    Cell biology and toxicology, 1991, Volume: 7, Issue:1

    Topics: Animals; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Ethacrynic Acid; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Isoxazoles; Liver; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Tumor Cells, Cultured

1991
The effects of R-75,317 on antiglomerular basement membrane glomerulonephritis in rats.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Acetylglucosaminidase; Animals; Basement Membrane; Biomarkers; Blood Pressure; Creatinine; Female; Glomerulonephritis; Immune Sera; Isoxazoles; Kidney; Kidney Glomerulus; Platelet Activating Factor; Proteinuria; Rats; Rats, Inbred Strains; Thiazoles

1991
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:2

    Topics: Animals; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles

1991
Glutathione metabolism at the blood-cerebrospinal fluid barrier.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:13

    Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines

1989
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:3

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles

1986
Synthesis of some new heterocyclic systems derived from 2-acetylbenzimidazole.
    Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986), 1993, Volume: 57, Issue:4

    Topics: Azoles; Benzimidazoles; Heterocyclic Compounds; Isoxazoles; Microbial Sensitivity Tests; Organoselenium Compounds; Pyrazoles; Thiazoles

1993
Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine.
    Journal of medicinal chemistry, 1994, Dec-23, Volume: 37, Issue:26

    Topics: Animals; Brain; Dopamine; Isoxazoles; Ligands; Nicotinic Agonists; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Thiazoles

1994
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.
    Journal of medicinal chemistry, 1994, Jul-22, Volume: 37, Issue:15

    Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Isoxazoles; Male; Mice; Rats; Rats, Wistar; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles

1994
The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.
    The Journal of antibiotics, 1995, Volume: 48, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Furans; Humans; Isoxazoles; Mice; Mupirocin; Oxazoles; Pyrazoles; Pyridines; Sepsis; Staphylococcal Infections; Thiazoles; Thiophenes

1995
Leflunomide interferes with pyrimidine nucleotide biosynthesis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:8

    Topics: Animals; Concanavalin A; Female; Humans; Immunosuppressive Agents; In Vitro Techniques; Indicators and Reagents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; PC12 Cells; Pyrimidine Nucleotides; Rats; Spleen; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured

1995
Synthesis of 3-methyl-4-[(2,4-dihydro-4-substituted-3H-1,2,4-triazole-3-thione-5-yl) phenylhydrazono]-5-isoxazolone and evaluation of their antimicrobial activities.
    Drug metabolism and drug interactions, 1995, Volume: 12, Issue:2

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Bacteria; Fungi; Isoxazoles; Mass Spectrometry; Microbial Sensitivity Tests; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles

1995
Biological studies on 1,2-benzisothiazole derivatives VI Antimicrobial activity of 1,2-benzisothiazole and 1,2-benzisothiazolin-3-one derivatives and of some corresponding 1,2-benzisoxazoles.
    Farmaco (Societa chimica italiana : 1989), 1996, Volume: 51, Issue:11

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Fungi; Isoxazoles; Structure-Activity Relationship; Thiazoles

1996
Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors.
    Journal of neuroscience research, 1998, May-01, Volume: 52, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hexachlorocyclohexane; Insecticides; Isoxazoles; Mice; Mitochondria; Neurons; Synaptic Transmission; Tetrazolium Salts; Thiazoles

1998
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
    European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3

    Topics: 3T3 Cells; Administration, Oral; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pioglitazone; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone

1999
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
    Chemistry & biology, 1999, Volume: 6, Issue:4

    Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction

1999
Triglyceride-lowering effect of a novel insulin-sensitizing agent, JTT-501.
    European journal of pharmacology, 1999, May-28, Volume: 373, Issue:1

    Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Isoxazoles; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides

1999
Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions.
    British journal of clinical pharmacology, 2000, Volume: 49 Suppl 1

    Topics: Antipsychotic Agents; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Isoxazoles; Liver; Microsomes, Liver; Paliperidone Palmitate; Piperazines; Pyrimidines; Risperidone; Sulfones; Sulfoxides; Thiazoles

2000
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats.
    British journal of pharmacology, 2000, Volume: 130, Issue:3

    Topics: Absorptiometry, Photon; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Cataract; Chromans; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Eating; Hypoglycemic Agents; Isoxazoles; Male; Neural Conduction; Obesity; Pancreas; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone

2000
Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts.
    European journal of pharmacology, 2000, Jul-14, Volume: 400, Issue:1

    Topics: Animals; Chromans; Dose-Response Relationship, Drug; Hemodynamics; Hypoglycemic Agents; Indomethacin; Isoxazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Pioglitazone; Prostaglandins; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E

2000
Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes.
    Brain research, 2001, Jan-19, Volume: 889, Issue:1-2

    Topics: Animals; Astrocytes; Astrocytoma; Cell Line; Enzyme Activation; Immunosuppressive Agents; Indicators and Reagents; Interferon-gamma; Isoxazoles; Leflunomide; Lipopolysaccharides; Mitogen-Activated Protein Kinase Kinases; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein-Tyrosine Kinases; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles

2001
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
    European journal of pharmacology, 2001, Jun-29, Volume: 423, Issue:1

    Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone

2001
A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.
    The Biochemical journal, 2001, Aug-01, Volume: 357, Issue:Pt 3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Isoxazoles; Kinetics; Meloxicam; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sheep; Sulfonamides; Thiazines; Thiazoles

2001
Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms.
    Cytokine, 2002, Aug-21, Volume: 19, Issue:4

    Topics: Aniline Compounds; Animals; Cell Line; Cell Survival; Cells, Cultured; Coloring Agents; Crotonates; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Guanidines; Humans; Hydroxybutyrates; Immunosuppressive Agents; Interferon-gamma; Interleukin-6; Isoxazoles; Leflunomide; Macrophages; Mice; Mycophenolic Acid; Nitric Oxide Synthase; Nitriles; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Rolipram; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines

2002
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
    European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine

2003
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
    Bioorganic & medicinal chemistry letters, 2003, Mar-10, Volume: 13, Issue:5

    Topics: Administration, Oral; Animals; Biological Availability; COS Cells; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Isoxazoles; Mice; Mice, Mutant Strains; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors

2003
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:7

    Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles

2005
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.
    Atherosclerosis, 2004, Volume: 177, Issue:2

    Topics: Animals; Antioxidants; Celecoxib; Cholesterol, LDL; Chromans; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Isoprostanes; Isoxazoles; Lactones; Meloxicam; Naproxen; Oxidation-Reduction; Pyrazoles; Sulfonamides; Sulfones; Thiazines; Thiazoles

2004
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
    Bioorganic & medicinal chemistry letters, 2005, May-02, Volume: 15, Issue:9

    Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles

2005
Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:9

    Topics: Anthralin; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Proliferation; Cells, Cultured; Diterpenes; Enzyme Inhibitors; Epoxy Compounds; Humans; I-kappa B Proteins; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-8; Isoxazoles; Keratinocytes; Leflunomide; NF-kappa B; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles

2005
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.
    Journal of medicinal chemistry, 2006, Nov-30, Volume: 49, Issue:24

    Topics: Acetylene; Animals; Aryl Hydrocarbon Hydroxylases; Crystallography, X-Ray; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Furans; Humans; Imidazoles; In Vitro Techniques; Isoxazoles; Mice; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Nicotine; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiazoles; Thiophenes; Time Factors

2006
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
    Bioorganic & medicinal chemistry letters, 2007, Mar-15, Volume: 17, Issue:6

    Topics: Acetyl-CoA Carboxylase; Alkynes; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydroxyurea; Isoxazoles; Molecular Conformation; Recombinant Proteins; Structure-Activity Relationship; Thiazoles

2007
Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Oct-15, Volume: 858, Issue:1-2

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chromatography, Liquid; Clozapine; Haloperidol; Isoxazoles; Male; Olanzapine; Paliperidone Palmitate; Piperazines; Pyrimidines; Rats; Reproducibility of Results; Risperidone; Tandem Mass Spectrometry; Thiazoles

2007
The active metabolite of leflunomide A771726 inhibits corneal neovascularization.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:3

    Topics: Aniline Compounds; Animals; Cell Nucleus; Cell Proliferation; Corneal Neovascularization; Crotonates; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines; Umbilical Veins

2008
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
    The Journal of surgical research, 2009, Volume: 151, Issue:1

    Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles

2009
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.
    Indian journal of experimental biology, 2008, Volume: 46, Issue:1

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Female; Glutaminase; Glutamine; Humans; In Vitro Techniques; Isoxazoles; Laminin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor A

2008
The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.
    The Tohoku journal of experimental medicine, 2008, Volume: 216, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Auditory Threshold; Cochlea; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Indomethacin; Isoxazoles; Lipoxygenase Inhibitors; Masoprocol; Meloxicam; Mice; Mice, Inbred Strains; Neuroprotective Agents; Pyrazoles; Sulfones; Thiazines; Thiazoles

2008
Effects of quetiapine, risperidone, 9-hydroxyrisperidone and ziprasidone on the survival of human neuronal and immune cells in vitro.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:3

    Topics: Adenosine Triphosphate; Antipsychotic Agents; Cell Line; Cell Survival; Dibenzothiazepines; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Isoxazoles; Monocytes; Neurons; Paliperidone Palmitate; Piperazines; Pyrimidines; Quetiapine Fumarate; Risperidone; Thiazoles

2010
Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles.
    Journal of combinatorial chemistry, 2009, Mar-09, Volume: 11, Issue:2

    Topics: Benzene Derivatives; Cyclization; Halogenation; Isoxazoles; Molecular Structure; Thiazoles

2009
Synthesis and herbicidal activities of novel 4-(4-(5-methyl-3-arylisoxazol-4-yl)thiazol-2-yl)piperidyl carboxamides and thiocarboxamides.
    Molecules (Basel, Switzerland), 2009, Mar-24, Volume: 14, Issue:3

    Topics: Binding, Competitive; Computer Simulation; Herbicides; Isoxazoles; Models, Molecular; Piperidines; Plant Proteins; Protease Inhibitors; Spinacia oleracea; Thiazoles

2009
[Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia].
    Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:1

    Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Colombia; Diagnostic Services; Direct Service Costs; Disease Management; Drug Costs; Drug Therapy, Combination; Etanercept; Health Care Costs; Hospital Costs; Hospitals, University; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Thiazines; Thiazoles

2009
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
    Neuroscience bulletin, 2010, Volume: 26, Issue:1

    Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Isoxazoles; Lactones; Lipid Peroxidation; Male; Meloxicam; Memory; Mice; Motor Activity; Naproxen; Nitrites; Random Allocation; Stress, Psychological; Sulfonamides; Sulfones; Thiazines; Thiazoles

2010
X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
    Journal of molecular biology, 2010, May-28, Volume: 399, Issue:1

    Topics: Benzoates; Benzylamines; Binding Sites; Crystallography, X-Ray; Dimerization; Isoxazoles; Ligands; Liver X Receptors; Models, Molecular; Orphan Nuclear Receptors; Phenylacetates; Sequence Alignment; Signal Transduction; Thiazoles

2010
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jul-20, Volume: 107, Issue:29

    Topics: Apoptosis; Cell Line, Tumor; Cell Respiration; Dihydroorotate Dehydrogenase; Electron Transport Complex III; Humans; Isoxazoles; Leflunomide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases Acting on CH-CH Group Donors; Potassium Cyanide; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrimidines; Quinone Reductases; Reactive Oxygen Species; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Up-Regulation

2010
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
    Oncology reports, 2010, Volume: 24, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma in Situ; Cell Death; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Piperazines; Sulfonamides; Thiazoles

2010
Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2010, Aug-09, Volume: 16, Issue:30

    Topics: Amino Acids, Diamino; Anthranilate Synthase; Intramolecular Transferases; Isoxazoles; Stereoisomerism; Thiazoles

2010
Bitter pills for drug companies.
    BMJ (Clinical research ed.), 2010, Sep-17, Volume: 341

    Topics: Acetamides; Drug Approval; Drug Industry; Fraud; gamma-Aminobutyric Acid; Isoxazoles; Linezolid; Motivation; Off-Label Use; Oxazolidinones; Piperazines; Pregabalin; Sulfonamides; Thiazoles; United States

2010
Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jun-01, Volume: 35, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Catatonia; Cyclooxygenase 2 Inhibitors; Inflammation; Isoxazoles; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mitochondria; Motor Activity; MPTP Poisoning; NADH Dehydrogenase; Neuroprotective Agents; Nitrites; Nitrobenzenes; Oxidative Stress; Signal Transduction; Sulfhydryl Compounds; Sulfonamides; Tetrazolium Salts; Thiazoles; Thiobarbituric Acid Reactive Substances; Transcription Factor RelA

2011
Update on newer antipsychotic drugs.
    Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:4

    Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Pregnancy; Schizophrenia; Thiazoles; Treatment Outcome

2011
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Antioxidants; Biphenyl Compounds; Free Radicals; Isoxazoles; Nitric Oxide; Oxazoles; Picrates; Pyrazoles; Thiazoles

2011
Biological perspectives: update on newer antipsychotic drugs: are they evidence based?
    Perspectives in psychiatric care, 2011, Volume: 47, Issue:4

    Topics: Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Dibenzocycloheptenes; Evidence-Based Medicine; Heterocyclic Compounds, 4 or More Rings; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoindoles; Isoxazoles; Lactones; Lurasidone Hydrochloride; Piperidines; Psychotic Disorders; Pyridines; Serotonin Receptor Agonists; Sulfones; Thiazoles

2011
Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Line, Tumor; Chemistry, Pharmaceutical; Cisplatin; Drug Design; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Inhibitory Concentration 50; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Mice; Models, Chemical; Neoplasms; Spectrophotometry, Infrared; Tetrazolium Salts; Thiazoles

2012
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.
    Bioorganic & medicinal chemistry, 2012, Apr-01, Volume: 20, Issue:7

    Topics: Antitubercular Agents; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Pyridines; Structure-Activity Relationship; Thiazoles

2012
Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.
    Journal of molecular modeling, 2012, Volume: 18, Issue:8

    Topics: Antitubercular Agents; Bacterial Proteins; Biphenyl Compounds; Catalytic Domain; Hydrogen Bonding; Isoxazoles; Molecular Dynamics Simulation; Phosphorous Acids; Protein Binding; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Thermodynamics; Thiazoles

2012
Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: Acid Phosphatase; Animals; Betulinic Acid; Bone Density Conservation Agents; Bone Resorption; Cathepsin K; Cell Differentiation; Cell Line; Cell Proliferation; Crystallography, X-Ray; Female; Isoenzymes; Isoxazoles; Mice; Mice, Inbred C57BL; Osteoclasts; Ovariectomy; Pentacyclic Triterpenes; Pyrazines; Pyrazoles; Pyrimidines; RANK Ligand; Rats; Structure-Activity Relationship; Tartrate-Resistant Acid Phosphatase; Thiazoles; Triterpenes

2012
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
    Bioorganic & medicinal chemistry letters, 2012, May-01, Volume: 22, Issue:9

    Topics: Central Nervous System; Cyclic Nucleotide Phosphodiesterases, Type 7; Humans; Isoxazoles; Parkinson Disease; Pharmacokinetics; Phosphodiesterase Inhibitors; Pyrimidinones; Structure-Activity Relationship; Thiazoles

2012
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles

2012
Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands.
    Molecules (Basel, Switzerland), 2012, Dec-24, Volume: 18, Issue:1

    Topics: Acetamides; Animals; CHO Cells; Cricetinae; Isoxazoles; Ligands; Oxazolidinones; Pyrrolidinones; Radioligand Assay; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Structure-Activity Relationship; Tetrazoles; Thiazoles

2012
Dynamics of Parecoxib or Meloxicam effect on acute postoperative pain after orthopedic surgical interventions: comparative study in hospitalized women and men.
    Khirurgiia, 2011, Issue:1

    Topics: Adolescent; Adult; Aged; Analgesia; Analgesics; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Meloxicam; Middle Aged; Orthopedic Procedures; Pain, Postoperative; Thiazines; Thiazoles; Young Adult

2011
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
    Oncogene, 2014, Nov-06, Volume: 33, Issue:45

    Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Fibroblasts; HEK293 Cells; Histones; Homologous Recombination; Humans; Isoxazoles; Mice, Knockout; Morpholines; Pyrimidines; Pyrones; Quinolines; Radiation Tolerance; Receptor, IGF Type 1; Recombinational DNA Repair; Thiazoles

2014
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
    Molecular cancer, 2013, Nov-05, Volume: 12, Issue:1

    Topics: Antineoplastic Agents; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dasatinib; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Imidazoles; Isoxazoles; Leflunomide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Radiation Tolerance; STAT5 Transcription Factor; STAT6 Transcription Factor; Thiazoles; Tumor Suppressor Proteins

2013
Impacts of a neonicotinoid, neonicotinoid-pyrethroid premix, and anthranilic diamide insecticide on four species of turf-inhabiting beneficial insects.
    Ecotoxicology (London, England), 2014, Volume: 23, Issue:2

    Topics: Animals; Bees; Coleoptera; Diamide; Guanidines; Hymenoptera; Insecticides; Isoxazoles; Neonicotinoids; ortho-Aminobenzoates; Plant Weeds; Pyrethrins; Thiazoles

2014
GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:9

    Topics: Action Potentials; Animals; Biophysics; Calcium; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Functional Laterality; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Oxygen Consumption; Partial Pressure; Pyridines; Receptors, GABA-A; Somatosensory Cortex; Sulfonamides; Thiazoles; Vibrissae; Zolpidem

2015
Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinylidene-chroman-2,4-diones on cancer and non-cancer cell growth and death.
    Bioorganic & medicinal chemistry, 2014, May-01, Volume: 22, Issue:9

    Topics: 4-Hydroxycoumarins; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Coumarins; Humans; Isoxazoles; MCF-7 Cells; Poly(ADP-ribose) Polymerases; Thiazoles; U937 Cells

2014
Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.
    European journal of medicinal chemistry, 2014, May-22, Volume: 79

    Topics: Animals; Carboxylic Acids; Cyclohexanes; Diacylglycerol O-Acyltransferase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoxazoles; Mice; Mice, Knockout; Molecular Conformation; Structure-Activity Relationship; Thiazoles

2014
Parenteral thermo-sensitive organogel for schizophrenia therapy, in vitro and in vivo evaluation.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Aug-18, Volume: 60

    Topics: Animals; Antipsychotic Agents; Coumarins; Drug Delivery Systems; Fatty Acids; Gels; Isoxazoles; Male; Mice, Nude; Paliperidone Palmitate; Phase Transition; Pyrimidines; Rats, Sprague-Dawley; Schizophrenia; Soybean Oil; Thiazoles; Transition Temperature; Viscosity

2014
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 350, Issue:2

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles

2014
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
    International journal of cancer, 2015, Jun-15, Volume: 136, Issue:12

    Topics: Blotting, Western; Boron Compounds; BRCA1 Protein; BRCA2 Protein; CDC2 Protein Kinase; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Repair; Histones; Homologous Recombination; Humans; Isoxazoles; Male; Microscopy, Fluorescence; Phosphorylation; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Quinolines; Rad51 Recombinase; Receptor, IGF Type 1; RNA Interference; Thiazoles

2015
Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: application to iloperidone.
    Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:4

    Topics: Antipsychotic Agents; Computer Simulation; Genotype; Humans; Isoxazoles; Models, Biological; Molecular Targeted Therapy; Neurobiology; Pharmacogenetics; Piperazines; Piperidines; Schizophrenia; Thiazoles

2015
Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases.
    Acta pharmaceutica (Zagreb, Croatia), 2015, Volume: 65, Issue:1

    Topics: 4-Hydroxycoumarins; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Isoxazoles; Lung Neoplasms; Thiazoles; Time Factors

2015
Synthesis, conformation and antiproliferative activity of isothiazoloisoxazole 1,1-dioxides.
    Organic & biomolecular chemistry, 2016, Feb-14, Volume: 14, Issue:6

    Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; MCF-7 Cells; Molecular Conformation; Structure-Activity Relationship; Thiazoles

2016
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.
    Bioorganic & medicinal chemistry letters, 2016, 06-15, Volume: 26, Issue:12

    Topics: Amidohydrolases; Analgesics; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Pain; Pain Measurement; Piperidines; Structure-Activity Relationship; Thiazoles

2016
Replacement of Oxygen by Sulfur in Small Organic Molecules. 3. Theoretical Studies on the Tautomeric Equilibria of the 2OH and 4OH-Substituted Oxazole and Thiazole and the 3OH and 4OH-Substituted Isoxazole and Isothiazole in the Isolated State and in Solu
    International journal of molecular sciences, 2016, Jul-09, Volume: 17, Issue:7

    Topics: Isomerism; Isoxazoles; Models, Theoretical; Oxazoles; Solutions; Sulfur; Thermodynamics; Thiazoles

2016
Synthesis and biological evaluation of novel isoxazolines linked via piperazine to 2- benzoisothiazoles as potent apoptotic agents.
    European journal of medicinal chemistry, 2017, Jan-27, Volume: 126

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Design; Humans; Isoxazoles; Piperazines; Thiazoles; Time Factors

2017
Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:8

    Topics: Animals; Cocaine; Dopamine; Isoxazoles; Kynurenic Acid; Male; Nicotine; Nucleus Accumbens; Phenylurea Compounds; Rats; Recurrence; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Sulfonamides; Thiazoles

2017
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
    Journal of medicinal chemistry, 2017, 06-08, Volume: 60, Issue:11

    Topics: Anilides; Area Under Curve; Benzamides; Cell Line; Drug Discovery; Half-Life; Humans; Isoxazoles; Molecular Probes; Muscular Atrophy, Spinal; Protein Processing, Post-Translational; Protein Stability; Quinolones; Structure-Activity Relationship; Survival of Motor Neuron 1 Protein; Thiazoles

2017
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.
    Journal of medicinal chemistry, 2017, 08-24, Volume: 60, Issue:16

    Topics: Antitubercular Agents; Bacterial Proteins; Drug Design; Drug Resistance, Multiple, Bacterial; Drug Stability; Ethidium; Humans; Isoxazoles; Macrophages; Membrane Transport Proteins; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium tuberculosis; Thiazoles; Thioridazine; Verapamil

2017
Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules.
    ACS chemical neuroscience, 2018, 12-19, Volume: 9, Issue:12

    Topics: Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cellular Reprogramming; Cellular Reprogramming Techniques; Colforsin; Diamines; Glioblastoma; Heterocyclic Compounds, 4 or More Rings; Homeodomain Proteins; Humans; Isoxazoles; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; POU Domain Factors; Pyridines; Pyrimidines; Thiazoles; Thiophenes; Up-Regulation

2018
Heterocyclization of 2-Arylidenecyclohexan-1,3-dione: Synthesis of Thiophene, Thiazole, and Isoxazole Derivatives with Potential Antitumor Activities.
    Anti-cancer agents in medicinal chemistry, 2020, Volume: 20, Issue:3

    Topics: Acetates; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclization; Cyclohexanones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Molecular Structure; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-pim-1; src-Family Kinases; Structure-Activity Relationship; Thiazoles; Thiophenes

2020
Activated clotting factor X mediates mitochondrial alterations and inflammatory responses via protease-activated receptor signaling in alveolar epithelial cells.
    European journal of pharmacology, 2020, Feb-15, Volume: 869

    Topics: Apoptosis; Cell Line, Tumor; Dipeptides; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Factor Xa; Factor Xa Inhibitors; Humans; Inflammation; Isoxazoles; Mitochondria; Pyridines; Receptors, Proteinase-Activated; Signal Transduction; Thiazoles

2020
Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2.
    ChemMedChem, 2020, 09-16, Volume: 15, Issue:18

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Design; Humans; Isoxazoles; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Protein Binding; Protein Conformation, alpha-Helical; Proto-Oncogene Proteins c-mdm2; Pyrazoles; Structure-Activity Relationship; Thiazoles

2020
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: Allosteric Site; Animals; Electrons; Electrophysiological Phenomena; Humans; Isoxazoles; Ligands; Oocytes; Oxazoles; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides; Thiazoles; Xenopus laevis

2021
Synthesis and Biological Evaluation of Novel Pyrane Glycosides.
    Acta chimica Slovenica, 2020, Volume: 67, Issue:4

    Topics: Anti-Bacterial Agents; Antifungal Agents; Aspergillus niger; Bacteria; Candida albicans; Glycosides; Isoxazoles; Microbial Sensitivity Tests; Pyrans; Pyrazoles; Thiazoles

2020