Page last updated: 2024-08-21

isoxazoles and rupintrivir

isoxazoles has been researched along with rupintrivir in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (6.52)	18.2507
2000's	15 (32.61)	29.6817
2010's	23 (50.00)	24.3611
2020's	5 (10.87)	2.80

Authors

Authors	Studies
Brown, EL; Burke, BJ; Dragovich, PS; Ferre, RA; Ford, CE; Fuhrman, SA; Harr, JE; Hendrickson, TF; Kosa, MB; Lee, CA; Marakovits, JT; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Rejto, PA; Tuntland, T; Webber, SE; Worland, ST; Zhou, R	1
Binford, SL; Brothers, MA; Brown, EL; DeLisle, DM; Dragovich, PS; Ferre, RA; Ford, CE; Fuhrman, SA; Hendrickson, TF; Love, RA; Marakovits, JT; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Tikhe, J; Webber, SE; Worland, ST; Zalman, LS; Zhou, R	1
Binford, SL; Brothers, MA; Diem, MD; Dragovich, PS; Ford, CE; Fuhrman, SA; Jackson, RL; Maldonado, F; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Worland, ST; Zalman, LS; Zhou, R	1
Brothers, MA; Dragovich, PS; Patick, AK; Prins, TJ; Worland, ST; Zalman, LS; Zhou, R	1
Crump, CE; Hayden, FG; Kaiser, L	1
Turner, RB	1
Witherell, G	1
Hee, B; Lee, CA; Liang, B; Potts, BC; Zhang, KE	1
Gersten, M; Hsyu, PH; Kerr, BM; Penning, CA; Pithavala, YK	1
Anand, K; Hilgenfeld, R; Mesters, JR; Wadhwani, P; Ziebuhr, J	1
Chi-Burris, K; Gersten, M; Gwaltney, JM; Hayden, FG; Hsyu, P; Patick, AK; Smith, GJ; Turner, RB; Zalman, LS	1
Binford, SL; Brothers, MA; Maldonado, F; Matthews, DA; Meador, JW; Patick, AK; Weady, PT; Zalman, LS	1
Cheng, YS; Fang, JM; Huang, HJ; Jan, JT; Kuo, CJ; Kuo, TH; Liang, PH; Shie, JJ; Wong, CH; Wu, YT	1
Im, I; Jeon, ES; Kim, YC; Kwon, SJ; Lee, ES; Lee, WG; Lee, YJ; Park, OK; Park, WJ; Rho, SH; Sellamuthu, S; Yang, ST; Yun, SH	1
Tao, J; Zhao, L	1
Binford, SL; Brothers, MA; Maldonado, F; Matthews, DA; Patick, AK; Weady, PT	1
Moreira, R; Santos, MM	1
Cheng, YH; Kung, SH; Liao, NC; Liu, YN; Lu, WW; Tsai, MT	1
Hu, YW; Jiang, T; Shi, BS; Song, ZG; Yuan, ZH; Zhang, XN	1
Hilgenfeld, R	1
Hsu, JT; Hung, HC; Shih, SR; Teng, IF; Tseng, CP; Wang, HC	1
Chen, Z; Gao, F; Gao, GF; Jiang, H; Lin, D; Liu, H; Lu, G; Qi, J; Qian, W; Xu, X; Yan, J	1
Cui, S; Fan, T; Guo, L; Jin, Q; Lei, X; Wang, J; Wang, M; Wu, Z; Yao, X	1
Arnan, C; Canard, B; Coll, M; Costenaro, L; Coutard, B; Gorbalenya, AE; Janowski, R; Kaczmarska, Z; Norder, H; Solà, M	1
Chen, L; Hu, Y; Qin, B; Song, Z; Yuan, Z; Zhang, X	1
Guo, Y; Lou, Z; Rao, Z; Ren, Z; Yan, L; Yang, C; Zhang, N	1
Cai, Q; Cai, Y; Chen, C; Chen, S; Chen, X; Li, J; Li, N; Lin, T; Liu, L; Peng, X; Wang, X; Wu, C; Yin, K; Zhang, R	1
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M	1
Stock, I	1
Hilgenfeld, R; Jochmans, D; Ma, Q; Nascimento, MS; Neyts, J; Rocha-Pereira, J	1
Franco, D; Froeyen, M; Hilgenfeld, R; Leyssen, P; Neyts, J; Tijsma, A; Tucker, S	1
Ghildyal, R; Jans, DA; Jensen, LM; Walker, EJ	1
Cao, L; Gong, P; Lou, Z; Qing, J; Shang, L; Shu, B; Sun, Y; Wang, Y; Yin, Z	1
Ang, MJ; Cheong, YK; Chia, CS; Chu, JJ; Hill, J; Keller, TH; Lau, QY; Ng, FM; Ngoh, ZX; Peng, J; Poulsen, A; Tan, YW; Then, SW	1
George, S; Hilgenfeld, R; Lacroix, C; Leyssen, P; Neyts, J	1
Altmeyer, R; Gao, Q; Lan, K; Li, G; Wang, Y; Yuan, S; Zou, G	1
Hannongbua, S; Jetsadawisut, W; Kungwan, N; Meeprasert, A; Nutho, B; Rungrotmongkol, T; Wolschann, P	1
Cao, L; Shang, L; Sun, Y; Wang, Y; Yin, Z; Zhai, Y	1
Emmott, E; Goodfellow, I; Hosmillo, M; Kitano, M; Lu, J	1
Lv, W; Wang, Y; Zhang, M; Zhang, Y	1
Chen, S; Chen, X; Cheng, A; Jia, R; Liu, M; Liu, Y; Mao, S; Sun, D; Wang, M; Wen, X; Wu, Y; Yang, Q; Yu, Y; Zhang, L; Zhang, S; Zhao, X; Zhu, D	1
Chen, Z; Fan, K; Hou, H; Sun, Y; Yuan, S; Zhu, L	1
Beinke, S; Belyaev, NN; Braubach, P; Braun, A; Fieguth, HG; Hessel, EM; Jonigk, D; Lennon, MG; Obernolte, H; Saunders, KA; Schaudien, D; Sewald, K; Warnecke, G; Wilkens, L; Wronski, S; Zardo, P	1
Henes, M; Kurt Yilmaz, N; Lee, JM; Lockbaum, GJ; Nalivaika, EA; Schiffer, CA; Thompson, PR; Timm, J	1
Bervoets, L; Cuvry, A; Dai, W; de Witte, P; Li, B; Li, J; Liu, H; Neyts, J; Rocha-Pereira, J; Roux, E; Rymenants, J; Stylianidou, Z; Van Dycke, J	1
Croft, SN; Ghildyal, R; Walker, EJ	1

Reviews

6 review(s) available for isoxazoles and rupintrivir

Article	Year
The treatment of rhinovirus infections: progress and potential. Antiviral research, 2001, Volume: 49, Issue:1 Topics: 3C Viral Proteases; Antiviral Agents; Clinical Trials as Topic; Combined Modality Therapy; Common Cold; Cysteine Endopeptidases; Dietary Supplements; Drug Therapy, Combination; Echinacea; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Plant Extracts; Plants, Medicinal; Pyrrolidinones; Receptors, Virus; Rhinovirus; Valine; Viral Proteins; Zinc	2001
AG-7088 Pfizer. Current opinion in investigational drugs (London, England : 2000), 2000, Volume: 1, Issue:3 Topics: Antiviral Agents; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Humans; Isoxazoles; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine	2000
An integrated approach to developing chemoenzymatic processes at the industrial scale. Ernst Schering Foundation symposium proceedings, 2006, Issue:3 Topics: Bacillus; Biotechnology; Biotransformation; Catalysis; Chemistry, Pharmaceutical; Cost-Benefit Analysis; Drug Design; Enzymes; Fructose-Bisphosphate Aldolase; HIV Protease Inhibitors; Isoxazoles; Models, Chemical; Models, Theoretical; Oxazoles; Pharmaceutical Preparations; Phenylalanine; Pyrrolidines; Pyrrolidinones; Stereoisomerism; Valine	2006
Michael acceptors as cysteine protease inhibitors. Mini reviews in medicinal chemistry, 2007, Volume: 7, Issue:10 Topics: Animals; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Leucine; Molecular Structure; Oxazoles; Peptides; Phenylalanine; Pyrrolidines; Pyrrolidinones; Structure-Activity Relationship; Sulfones; Valine	2007
[Hand, foot and mouth disease--more than a harmless "childhood disease"]. Medizinische Monatsschrift fur Pharmazeuten, 2014, Volume: 37, Issue:1 Topics: Adult; Animals; Antiviral Agents; Child; Child, Preschool; Disease Outbreaks; Hand, Foot and Mouth Disease; Humans; Isoxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Pyrrolidinones; Valine	2014
Proteases of human rhinovirus: role in infection. Methods in molecular biology (Clifton, N.J.), 2015, Volume: 1221 Topics: 3C Viral Proteases; Active Transport, Cell Nucleus; Antiviral Agents; Cysteine Endopeptidases; Host-Pathogen Interactions; Humans; Isoxazoles; Peptide Hydrolases; Phenylalanine; Picornaviridae Infections; Pyrrolidinones; Rhinovirus; Valine; Viral Proteins; Virus Replication	2015

Trials

2 trial(s) available for isoxazoles and rupintrivir

Article	Year
Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:2 Topics: Adult; Antiviral Agents; Double-Blind Method; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Valine	2002
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:12 Topics: Administration, Inhalation; Adolescent; Adult; Antiviral Agents; Biological Availability; Common Cold; Double-Blind Method; Endpoint Determination; Female; Humans; Isoxazoles; Male; Middle Aged; Mucus; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Suspensions; Valine	2003

Article

Year

Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers.

Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:2

Topics: Adult; Antiviral Agents; Double-Blind Method; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Valine

2002

Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.

Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:12

Topics: Administration, Inhalation; Adolescent; Adult; Antiviral Agents; Biological Availability; Common Cold; Double-Blind Method; Endpoint Determination; Female; Humans; Isoxazoles; Male; Middle Aged; Mucus; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Suspensions; Valine

2003

Other Studies

38 other study(ies) available for isoxazoles and rupintrivir

Article	Year
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. Journal of medicinal chemistry, 1999, Apr-08, Volume: 42, Issue:7 Topics: 3C Viral Proteases; Antiviral Agents; Cell Line; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Glutamine; Humans; Isoxazoles; Lactams; Models, Molecular; Molecular Mimicry; Oligopeptides; Phenylalanine; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine; Viral Proteins	1999
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proceedings of the National Academy of Sciences of the United States of America, 1999, Sep-28, Volume: 96, Issue:20 Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Binding Sites; Crystallization; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Molecular Sequence Data; Phenylalanine; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine; Viral Proteins	1999
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:10 Topics: 3C Viral Proteases; Antiviral Agents; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HeLa Cells; Humans; Isoxazoles; Microbial Sensitivity Tests; Phenylalanine; Proteins; Pyrrolidinones; Rhinovirus; Serotyping; Valine; Viral Proteins	1999
Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:5 Topics: 3C Viral Proteases; Antiviral Agents; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytokines; HeLa Cells; Humans; Isoxazoles; Microbial Sensitivity Tests; Phenylalanine; Pyrrolidinones; Rhinovirus; Time Factors; Valine; Viral Proteins	2000
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses. Antiviral research, 2000, Volume: 47, Issue:3 Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Common Cold; Humans; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Spectrophotometry; Valine	2000
Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:5 Topics: 3C Viral Proteases; Animals; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dogs; Haplorhini; Humans; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Mimicry; Molecular Structure; Peptides; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Valine; Viral Proteins	2001
Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science (New York, N.Y.), 2003, Jun-13, Volume: 300, Issue:5626 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Coronavirus 229E, Human; Coronavirus 3C Proteases; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimerization; Drug Design; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrrolidinones; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Transmissible gastroenteritis virus; Valine	2003
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:2 Topics: 3C Viral Proteases; Amino Acids; Antiviral Agents; Conserved Sequence; Cysteine Endopeptidases; HeLa Cells; Humans; Isoxazoles; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; RNA, Viral; Valine; Viral Proteins	2005
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorganic & medicinal chemistry, 2005, Sep-01, Volume: 13, Issue:17 Topics: Animals; Blotting, Western; Chlorocebus aethiops; Computer Simulation; Coronavirus 3C Proteases; Cysteine Endopeptidases; Endopeptidases; Enzyme Inhibitors; Esters; Isoxazoles; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Mimicry; Peptides; Phenylalanine; Pyrrolidinones; Valine; Vero Cells; Viral Proteins	2005
Development of potent inhibitors of the coxsackievirus 3C protease. Biochemical and biophysical research communications, 2007, Jun-22, Volume: 358, Issue:1 Topics: 3C Viral Proteases; Amino Acid Substitution; Amino Acids; Antiviral Agents; Binding Sites; Cell Survival; Cysteine Endopeptidases; Enterovirus; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Models, Molecular; Phenylalanine; Pyrrolidinones; Rhinovirus; Valine; Viral Proteins; Virus Replication	2007
In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Cysteine Endopeptidases; Drug Resistance, Viral; Genotype; Humans; Isoxazoles; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Phenotype; Phenylalanine; Pyrrolidinones; Rhinovirus; Sequence Homology, Amino Acid; Valine; Viral Proteins	2007
Real-time monitoring of human enterovirus (HEV)-infected cells and anti-HEV 3C protease potency by fluorescence resonance energy transfer. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: 3C Viral Proteases; Antiviral Agents; Biosensing Techniques; Blotting, Western; Cell Fusion; Cell Line; Cysteine Endopeptidases; Enterovirus A, Human; Enterovirus Infections; Fluorescence Resonance Energy Transfer; Fluorometry; Green Fluorescent Proteins; HeLa Cells; Herpesvirus 1, Human; Humans; Image Processing, Computer-Assisted; Isoxazoles; Microbial Sensitivity Tests; Phenylalanine; Plasmids; Pyrrolidinones; Recombinant Proteins; Transfection; Valine; Viral Plaque Assay; Viral Proteins	2009
Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. World journal of gastroenterology, 2010, Jan-14, Volume: 16, Issue:2 Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Cysteine Endopeptidases; Enterovirus A, Human; Enterovirus Infections; Humans; Isoxazoles; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Retrospective Studies; Treatment Outcome; Valine; Viral Proteins	2010
Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia. Future medicinal chemistry, 2010, Volume: 2, Issue:7 Topics: Animals; Antiviral Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Developed Countries; Developing Countries; Drug Design; Humans; Isoxazoles; Phenylalanine; Protease Inhibitors; Pyrrolidinones; RNA Virus Infections; RNA Viruses; Valine	2010
Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir. The Journal of infectious diseases, 2011, Jun-15, Volume: 203, Issue:12 Topics: Algorithms; Animals; Antiviral Agents; Blotting, Western; Chlorocebus aethiops; DNA Primers; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Enterovirus A, Human; Enterovirus Infections; Humans; Interferon-alpha; Interferon-Stimulated Gene Factor 3, gamma Subunit; Isoxazoles; Phenylalanine; Polymerase Chain Reaction; Pyrrolidinones; Recombinant Proteins; Rhabdomyosarcoma; Tumor Cells, Cultured; Valine; Vero Cells; Virus Replication	2011
Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. Journal of virology, 2011, Volume: 85, Issue:19 Topics: 3C Viral Proteases; Antiviral Agents; Crystallography, X-Ray; Cysteine Endopeptidases; Drug Design; Enterovirus A, Human; Hand, Foot and Mouth Disease; Humans; Isoxazoles; Models, Molecular; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins	2011
Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. Journal of virology, 2011, Volume: 85, Issue:19 Topics: 3C Viral Proteases; Amino Acid Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Enterovirus A, Human; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins	2011
Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. Journal of virology, 2011, Volume: 85, Issue:20 Topics: 3C Viral Proteases; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Cysteine Endopeptidases; Enterovirus; Enzyme Inhibitors; Humans; Isoxazoles; Models, Molecular; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins	2011
Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model. Antiviral research, 2013, Volume: 97, Issue:3 Topics: Animals; Antiviral Agents; Drug Evaluation, Preclinical; Enterovirus A, Human; Enterovirus Infections; Female; Humans; Infant; Isoxazoles; Male; Mice; Phenylalanine; Pyrrolidinones; Valine; Virus Replication	2013
The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease. Protein & cell, 2013, Volume: 4, Issue:4 Topics: Binding Sites; Coronavirus 3C Proteases; Cysteine Endopeptidases; Humans; Isoxazoles; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Pyrrolidinones; Rhinovirus; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Valine; Viral Proteins	2013
Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. Acta crystallographica. Section D, Biological crystallography, 2013, Volume: 69, Issue:Pt 5 Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Cell Line; Conserved Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enterovirus A, Human; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protein Conformation; Pyrrolidinones; Valine; Viral Proteins	2013
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3 Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication	2014
The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8 Topics: Amides; Antiviral Agents; Cell Line; Cysteine Endopeptidases; Cytidine; Drug Combinations; Drug Synergism; Hepatocytes; Humans; Isoxazoles; Molecular Docking Simulation; Norwalk virus; Papain; Phenylalanine; Pyrazines; Pyrrolidinones; Replicon; RNA-Dependent RNA Polymerase; Valine; Viral Proteins; Virus Replication	2014
The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Antiviral Agents; Benzimidazoles; Capsid; Capsid Proteins; Drug Resistance, Viral; Enterovirus A, Human; Enterovirus Infections; Isoxazoles; Molecular Docking Simulation; Oximes; Phenylalanine; Piperidines; Protease Inhibitors; Protein Binding; Pyridazines; Pyrrolidinones; Sulfonamides; Valine; Virus Replication	2014
An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation. Antiviral research, 2014, Volume: 112 Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Drug Synergism; Enterovirus A, Human; Humans; Isoxazoles; Phenylalanine; Pyrrolidinones; RNA-Dependent RNA Polymerase; Valine; Virus Replication	2014
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. Journal of enzyme inhibition and medicinal chemistry, 2016, Volume: 31, Issue:2 Topics: 3C Viral Proteases; Antiviral Agents; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Cysteine Endopeptidases; Enterovirus A, Human; Inhibitory Concentration 50; Isoxazoles; Peptidomimetics; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Structure-Activity Relationship; Valine; Viral Proteins	2016
The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:9 Topics: Antiviral Agents; Drug Resistance, Viral; Enterovirus; Isoxazoles; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Valine; Viral Proteins; Virus Replication	2015
In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:9 Topics: Amides; Amino Acid Sequence; Animals; Antiviral Agents; Binding Sites; Cell Line, Tumor; Chlorocebus aethiops; Drug Combinations; Drug Resistance, Viral; Drug Synergism; Enterovirus A, Human; Humans; Indoles; Isoxazoles; Itraconazole; Molecular Docking Simulation; Mutation; Myoblasts; Phenols; Phenylalanine; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Pyrazines; Pyrrolidinones; Sequence Alignment; Sequence Homology, Amino Acid; Suramin; Valine; Vero Cells; Viral Nonstructural Proteins; Virus Replication	2016
Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: A molecular dynamics study. Biophysical chemistry, 2016, Volume: 219 Topics: 3C Viral Proteases; Cysteine Endopeptidases; Drug Design; Enterovirus; Enterovirus A, Human; Enzyme Inhibitors; Hand, Foot and Mouth Disease; Humans; In Vitro Techniques; Isoxazoles; Molecular Dynamics Simulation; Oligopeptides; Peptides; Phenylalanine; Protein Binding; Pyrrolidinones; Valine; Viral Proteins	2016
Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:7 Topics: 3C Viral Proteases; Antiviral Agents; Cysteine Endopeptidases; Enterovirus; Hand, Foot and Mouth Disease; Isoxazoles; Mutation; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins	2017
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:5 Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Cell Line, Tumor; Cysteine Endopeptidases; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Mutation; Norwalk virus; Phenylalanine; Pyrrolidinones; Valine; Viral Proteins; Virus Replication	2018
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses. Scientific reports, 2019, 04-15, Volume: 9, Issue:1 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Luminescent Measurements; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Valine; Vero Cells	2019
Biochemical characterization of recombinant Avihepatovirus 3C protease and its localization. Virology journal, 2019, 04-29, Volume: 16, Issue:1 Topics: 3C Viral Proteases; Cysteine Endopeptidases; Hepatitis Virus, Duck; Hydrogen-Ion Concentration; Isoxazoles; Kinetics; Phenylalanine; Phylogeny; Pyrrolidinones; Recombinant Proteins; Sequence Alignment; Valine; Viral Proteins	2019
Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virologica Sinica, 2020, Volume: 35, Issue:4 Topics: 3C Viral Proteases; Antiviral Agents; Crystallography, X-Ray; Drug Design; Enterovirus A, Human; Isoxazoles; Models, Molecular; Phenylalanine; Protein Structure, Tertiary; Pyrrolidinones; Sequence Analysis, DNA; Valine	2020
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures. American journal of respiratory cell and molecular biology, 2021, Volume: 65, Issue:5 Topics: Aged; Antiviral Agents; Asthma; Bronchi; Epithelial Cells; Female; Gene Expression Profiling; Genome, Human; Host-Pathogen Interactions; Humans; Isoxazoles; Lung; Male; Middle Aged; Phenylalanine; Picornaviridae Infections; Pulmonary Disease, Chronic Obstructive; Pyrrolidinones; Rhinovirus; Valine	2021
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry, 2021, 10-05, Volume: 60, Issue:39 Topics: Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Enterovirus D, Human; Hydrogen Bonding; Isoxazoles; Phenylalanine; Protein Binding; Pyrrolidinones; SARS-CoV-2; Static Electricity; Valine	2021
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo. Viruses, 2021, 09-16, Volume: 13, Issue:9 Topics: Animals; Caliciviridae Infections; Cell Line; Cytopathogenic Effect, Viral; Drug Resistance, Viral; Isoxazoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Mutation; Norovirus; Peptide Hydrolases; Phenylalanine; Pyrrolidinones; Replicon; RNA, Viral; Small Molecule Libraries; Valine; Viral Protease Inhibitors; Virus Replication; Zebrafish	2021
RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups. Viruses, 2021, 11-30, Volume: 13, Issue:12 Topics: 3C Viral Proteases; Antiviral Agents; Apoptosis; HeLa Cells; Host-Pathogen Interactions; Humans; Isoxazoles; Phenylalanine; Picornaviridae Infections; Protease Inhibitors; Pyrrolidinones; Rhinovirus; Valine	2021