isoxazoles has been researched along with pyrimidine in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J | 1 |
| Hartung, HP; Jung, S; Korn, T; Toyka, K | 1 |
| Glover, M; Jawad, AS; Soliotis, F | 1 |
| Arai, Y; Hakeda, Y; Kaneda, T; Kobayashi, Y; Kumegawa, M; Sato, T; Shin, K; Ueyama, S; Yoshida, Y | 1 |
| Stuhlmeier, KM | 1 |
| Al-Kadasi, K; Sawka-Dobrowolska, W; Wagner, E; Zimecki, M | 1 |
| Chernyak, BV; Chumakov, PM; Evstafieva, AG; Khutornenko, AA; Roudko, VV; Vartapetian, AB | 1 |
| Kumar, RA; Rajendra Prasad, KJ; Yamuna, E; Zeller, M | 1 |
| Carnovale, C; Chiacchio, MA; Cirmi, S; Garozzo, A; Giofrè, SV; Mancuso, R; Navarra, M; Romeo, R | 1 |
| Asara, JM; Brown, KK; Spinelli, JB; Toker, A | 1 |
| Cao, S; Efstratiou, A; Igarashi, I; Kamyingkird, K; Mousa, AA; Nishikawa, Y; Salama, A; Tuvshintulga, B; Xuan, X; Yokoyama, N | 1 |
| Almaz, Z; Camadan, Y; Gokcen, T; Gören, AC; Gülçin, İ; Kalin, R; Köksal, Z; Ozdemir, H; Usanmaz, H | 1 |
2 review(s) available for isoxazoles and pyrimidine
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Severe skin reaction after leflunomide and etanercept in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Erythema; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Pyrimidines; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2002 |
11 other study(ies) available for isoxazoles and pyrimidine
| Article | Year |
|---|---|
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea | 1985 |
Suppression of experimental autoimmune neuritis by leflunomide.
Topics: Adoptive Transfer; Animals; Autoantibodies; Calcium; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Myelin Proteins; Neuritis, Autoimmune, Experimental; Pyrimidines; Rats; Rats, Inbred Lew; Sciatic Nerve; T-Lymphocytes | 2001 |
The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage.
Topics: Aniline Compounds; Animals; Binding Sites; Bone Resorption; Carrier Proteins; Cell Differentiation; Cell Lineage; Cells, Cultured; Crotonates; Electrophoretic Mobility Shift Assay; Hydroxybutyrates; Isoxazoles; Leflunomide; Membrane Glycoproteins; Mice; NF-kappa B; Nitriles; Osteoclasts; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Rabbits; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Toluidines | 2004 |
Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Enzyme Repression; Fibroblasts; Glucuronosyltransferase; Humans; Hyaluronan Synthases; Hyaluronic Acid; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; NF-kappa B; Protein Transport; Pyrimidines; RNA, Messenger; Synovial Membrane; Transcription, Genetic; Uridine | 2005 |
Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Male; Mice; Models, Molecular; Molecular Structure; Pyrimidines; Spleen | 2008 |
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Respiration; Dihydroorotate Dehydrogenase; Electron Transport Complex III; Humans; Isoxazoles; Leflunomide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases Acting on CH-CH Group Donors; Potassium Cyanide; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrimidines; Quinone Reductases; Reactive Oxygen Species; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles.
Topics: Anti-Bacterial Agents; Hydrogen Bonding; Indoles; Isoxazoles; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; Pyrazoles; Pyrimidines; Software; Structure-Activity Relationship | 2012 |
Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a new class of C-nucleosides.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Hep G2 Cells; HT29 Cells; Humans; Isoxazoles; Molecular Mimicry; Molecular Structure; Nucleosides; Pyrimidines; Structure-Activity Relationship | 2015 |
Adaptive Reprogramming of
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cellular Reprogramming; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Isoxazoles; Leflunomide; Mice; Pyrimidines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Atovaquone; Babesia; Babesiosis; Biphenyl Compounds; Computational Biology; Dihydroorotate Dehydrogenase; Diminazene; Enzyme Inhibitors; Horse Diseases; Horses; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Mice; Molecular Weight; Oxidoreductases Acting on CH-CH Group Donors; Phylogeny; Plasmodium berghei; Pyrimidines; Theileria; Theileriasis | 2017 |
Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors.
Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Isoxazoles; Lactoperoxidase; Pyridines; Pyrimidines; Sulfonamides; Thiadiazoles | 2017 |