Page last updated: 2024-08-21

isoxazoles and pnu 120596

isoxazoles has been researched along with pnu 120596 in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (17.02)	29.6817
2010's	70 (74.47)	24.3611
2020's	8 (8.51)	2.80

Authors

Authors	Studies
Allaman, G; Arneric, SP; Berkenpas, MB; Bertrand, D; Bertrand, S; Groppi, VE; Hajós, M; Higdon, NR; Hoffmann, WE; Hurst, RS; Lawson, JA; Ogier, R; Piotrowski, DW; Raggenbass, M; Rutherford-Root, KL; Wall, TM	1
Briggs, CA; Gopalakrishnan, M; Grønlien, JH; Håkerud, M; Malysz, J; Thorin-Hagene, K; Ween, H	1
Bothmann, H; Dunlop, J; Jow, B; Jow, F; Kramer, A; Papini, S; Roncarati, R; Seredenina, T; Terstappen, GC	1
Hone, A; Innocent, N; Kimura, A; Livingstone, PD; McIntosh, JM; Whiteaker, P; Wonnacott, S; Young, T	1
Millar, NS; Sher, E; Walker, AS; Young, GT; Zwart, R	1
Bowlby, MR; Dunlop, J; Friis, S; Mathes, C; Sunesen, M	1
Beach, JW; Buccafusco, JJ; Terry, AV	1
Arnaudeau, S; Bertrand, D; Demaurex, N; Gilbert, D; Lecchi, M	1
Anwyl, R; Rowan, MJ; Welsby, PJ	1
Angulo, MC; Audinat, E; Vélez-Fort, M	1
Anderson, DJ; El Kouhen, R; Gopalakrishnan, M; Hu, M; Li, J	1
Barron, SC; McLaughlin, JT; Richards, VL; Rosenberg, RL; See, JA	1
Akamatsu, M; Almond, A; Blundell, CD; Buckingham, SD; Jones, AK; Matsuda, K; Pienaar, I; Pienaar, IS; Sattelle, BM; Sattelle, DB	1
Dickinson, JA; Kew, JN; Livingstone, PD; Srinivasan, J; Wonnacott, S	1
Ahring, PK; Briggs, CA; Dyhring, T; Gopalakrishnan, M; Grønlien, JH; Håkerud, M; Malysz, J; Thorin-Hagene, K; Timmermann, DB; Trumbull, JD; Ween, H; Xiong, Y	1
Kem, WR; López-Hernández, GY; Morain, P; Papke, RL; Soti, F; Thinschmidt, JS; Trocme-Thibierge, C	1
Gusev, AG; Uteshev, VV	1
Gopalakrishnan, M; Hu, M; Li, J	1
Ciuraszkiewicz, A; David, R; Huck, S; McIntosh, JM; Orr-Urtreger, A; Papke, RL; Scholze, P; Simeone, X	1
Ahring, PK; Anderson, DJ; Briggs, CA; Bunnelle, WH; Dyhring, T; Gopalakrishnan, M; Gopalakrishnan, S; Grønlien, JH; Gubbins, E; Håkerud, M; Helfrich, R; Hu, M; Ji, J; Li, J; Malysz, J; Meyer, MD; Nielsen, EØ; Peters, D; Puttfarcken, PS; Thorin-Hagene, K; Timmermann, DB; Ween, H	1
Capelli, AM; Castelletti, L; Di Lenarda, E; Kew, JN; Lightfoot, A; Oliosi, B; Salvagno, C; Teague, S; Virginio, C	1
Horenstein, NA; Papke, RL; Stokes, C; Wang, J	2
Gusev, AG; Kalappa, BI; Uteshev, VV	1
Avila, J; Del Barrio, L; Egea, J; López, MG; Martín-de-Saavedra, MD; McIntosh, JM; Parada, E; Romero, A; Wonnacott, S	1
Araud, T; Berger, R; Bertrand, D; Graw, S; Lee, M; Leonard, S; Neveu, E	1
Collins, T; Millar, NS; Young, GT	1
Papke, RL; Wang, J; Williams, DK	1
Bouzat, C; Corradi, J; daCosta, CJ; Free, CR; Sine, SM	1
El-Sayed, M; Mikkelsen, JD; Thomsen, MS	1
Gendle, DF; Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ	1
He, XH; Li, H; Song, XM; Wang, YL; Zhan, J; Zhang, ZZ	1
Uteshev, VV	2
Christensen, J; Erichsen, H; Hansen, H; Hansen, R; Munro, G; Timmermann, D	1
Kimbrell, MR; Papke, RL; Peng, C; Williams, DK	1
Carroll, FI; Damaj, MI; Freitas, K; Negus, SS	1
Freitas, K; Ghosh, S; Imad Damaj, M; Ivy Carroll, F; Lichtman, AH	1
Carroll, FI; Damaj, MI; Freitas, K	1
Callahan, PM; Chapman, JM; Hutchings, EJ; Kille, NJ; Terry, AV	1
Pandya, AA; Yakel, JL	1
daCosta, CJ; Sine, SM	1
Jin, K; Johnson, SR; Kalappa, BI; Sun, F; Uteshev, VV	1
Chojnacka, K; Horenstein, NA; Papke, RL	1
Crooks, PA; Fifer, EK; Kimbrell, MR; Pack, TF; Papke, RL; Peng, C; Tian, C	1
Jin, K; Sun, F; Uteshev, VV	1
Kalappa, BI; Uteshev, VV	1
Abraham, N; Alewood, PF; Christie, MJ; Dutertre, S; Emidio, NB; Inserra, M; Jin, AH; Lewis, RJ; Murali, SS; Vetter, I	1
Mike, A; Pesti, K; Szabo, AK; Vizi, ES	2
Brown, JL; Wonnacott, S	1
Bencherif, M; Budygin, E; Grinevich, V; Grinevich, VP; Gutkin, B; Maex, R	1
Gatson, JW; Simpkins, JW; Uteshev, VV	1
Cano-Abad, MF; Egea, J; Fernández-Morales, JC; Guerra-Álvarez, M; López, MG; Moreno-Ortega, AJ; Navarro, E	1
Floyd, KL; Stevens, KE; Stitzel, JA; Zheng, L	1
Hao, Y; Tang, J; Wang, K	1
Chatzidaki, A; Dage, J; Fouillet, A; Li, J; Millar, NS; Sher, E; Ursu, D	1
Cheng, Q; Yakel, JL	1
Kos, T; Nikiforuk, A; Popik, P; Potasiewicz, A	1
Dougherty, DA; Lester, HA; Marotta, CB	1
Chang, Y; Du, Y; Guo, C; Huang, Y; Lukas, RJ; Xu, X; Xue, F; Zhang, J; Zhang, Q	1
Chaturbhuj, GU; Horenstein, NA; Kulkarni, AR; Manther, K; Papke, RL; Stokes, C; Thakur, GA	1
Allison, C; Kohli, S; Malcolm, E; Shoaib, M; Wood, C	1
Bredt, DS; Davini, WB; Gu, S; Harrington, AW; Lord, B; Matta, JA; Sutton, SW	1
Jin, K; Johnson, SR; Sun, F; Uteshev, VV	1
Bailey, CP; Udakis, M; Wonnacott, S; Wright, VL	1
Andersen, ND; Arias, HR; Bouzat, C; Corradi, J; Feuerbach, D; Nielsen, BE; Tolosa, MF	1
Bautista-Aguilera, OM; Chioua, M; Colmena, I; Criado, M; Gandía, L; Marco-Contelles, J; Mulet, J; Sala, F; Sala, S; Samadi, A	1
Alvarez, FJ; Liu, C; Reinert, NJ; Tang, P; Tillman, TS; Wang, D; Xiao, K; Xu, Y; Zhang, P	1
Abburi, C; Gallagher, K; McDaid, J; McGehee, DS; Wolfman, SL	1
Bortz, DM; Bruno, JP; Mikkelsen, JD; Upton, BA	1
Akbarali, HI; AlSharari, SD; Bagdas, D; Cabral, GA; Carroll, FI; Damaj, MI; Lichtman, PA; McGee, EA; Raborn, ES	1
Auber, A; Goldberg, SR; Justinova, Z; Panlilio, LV; Redhi, GH; Schindler, CW; Schwarcz, R; Secci, ME; Thorndike, EB	1
Hołuj, M; Nikiforuk, A; Popik, P; Potasiewicz, A	1
Niessen, KV; Rappenglück, S; Scheffel, C; Seeger, T; Thiermann, H; Wanner, KT; Worek, F	2
Adams, DJ; Corringer, PJ; Craik, DJ; Durek, T; Faure, G; Kasheverov, IE; Kudryavtsev, DS; Shelukhina, IV; Spirova, EN; Tae, HS; Thongyoo, P; Tsetlin, VI	1
Bak, E; Jafri, MS; Kabbani, N; King, JR; Ullah, A	1
Alzarea, S; Rahman, S	2
Gaidhani, N; Uteshev, VV	1
Bo, J; Gu, X; Hou, B; Huo, W; Lei, Y; Liu, Y; Liu, Z; Ma, Z; Mao, Y; Sun, R; Sun, Y; Zhang, W; Zhang, Y; Zhang, Z	1
Garai, S; Gulsevin, A; Horenstein, NA; Papke, RL; Quadri, M; Stokes, C; Thakur, GA	1
Cecon, E; Chollet, AM; Dam, J; Danober, L; Delagrange, P; Gautier, C; Jockers, R; Luka, M	1
Brandao-Araiza, S; Camacho-Hernandez, GA; Doan, L; Duggan, BM; Kaczanowska, K; Papke, RL; Stokes, C; Taylor, P	1
Hansen, SK; Hyttel, P; Larsen, HM; Mikkelsen, JD; Stummann, TC	1
Gzielo, K; Krawczyk, M; Nikiforuk, A; Popik, P; Potasiewicz, A	1
Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB	1
Kolbaev, SN; Kryukova, EV; Kudryavtsev, DS; Lebedev, DS; Tsetlin, VI; Utkin, YN; Vulfius, CA	1
Aricioglu, F; Sirvanci, S; Unal, G	1
Islam, MS; Mikami, D; Muramatsu, I; Nakazawa, H; Taniguchi, T; Uwada, J; Yazawa, T	1
Afify, EA; El-Ganainy, SO; El-Sayed, NS; Gowayed, MA; Matar, NA	1
Hibbs, RE; Howard, RJ; Lindahl, E; Noviello, CM; Zhuang, Y	1
Acker, BA; Badescu, VO; Berkenpas, MB; Groppi, VE; Hajós, M; Higdon, NR; Hurst, RS; Jon Jacobsen, E; Margolis, BJ; McWhorter, WW; Myers, JK; Piotrowski, DW; Rogers, BN; Sarapa, D; Vetman, TN; Walker, DP; Wall, TM; Wilhite, DM; Wishka, DG; Xu, W; Yates, KM	1

Reviews

2 review(s) available for isoxazoles and pnu 120596

Article	Year
Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:2 Topics: Allosteric Regulation; Animals; Binding Sites; Choline; Drug Design; Humans; Isoxazoles; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Piperazines; Pyridines; Rats; Receptors, Nicotinic	2009
α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum. Advances in experimental medicine and biology, 2012, Volume: 740 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic	2012

Other Studies

92 other study(ies) available for isoxazoles and pnu 120596

Article	Year
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Apr-27, Volume: 25, Issue:17 Topics: Acetylcholine; Acoustic Stimulation; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Amphetamine; Animals; Animals, Newborn; Calcium; Cell Line; Central Nervous System Stimulants; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Epithelial Cells; Evoked Potentials, Auditory; Hippocampus; Humans; In Vitro Techniques; Isoxazoles; Male; Membrane Potentials; Microinjections; Neurons; Nicotine; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tetrodotoxin; Time Factors; Xenopus	2005
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Molecular pharmacology, 2007, Volume: 72, Issue:3 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Benzylidene Compounds; Bridged Bicyclo Compounds; Calcium; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genistein; Humans; Indoles; Isoxazoles; Kidney; Microinjections; Naphthalenes; Nicotine; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein-Tyrosine Kinases; Pyridines; Quinolines; Receptors, Cholinergic; Receptors, Nicotinic; Sensitivity and Specificity; Sulfonamides; Xenopus laevis	2007
Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. Assay and drug development technologies, 2008, Volume: 6, Issue:2 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; CHO Cells; Cricetinae; Cricetulus; Electrophysiology; Enzyme Inhibitors; Fluorescent Dyes; Genistein; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Kinetics; Microscopy, Fluorescence; Nicotinic Agonists; Phenylurea Compounds; Receptors, Nicotinic; Recombinant Proteins; RNA; Transfection	2008
Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Calcium; Choline; Conotoxins; Dopamine; Humans; Isoxazoles; Male; Nicotinic Antagonists; PC12 Cells; Phenylurea Compounds; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spiro Compounds	2008
Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-23, Volume: 105, Issue:38 Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Amino Acids; Animals; Binding Sites; Chickens; Computer Simulation; Dose-Response Relationship, Drug; Humans; Isoxazoles; Mice; Models, Molecular; Mutant Chimeric Proteins; Mutation; Oocytes; Phenylurea Compounds; Protein Structure, Tertiary; Rats; Receptors, Nicotinic; Xenopus laevis	2008
Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology. Journal of neuroscience methods, 2009, Feb-15, Volume: 177, Issue:1 Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Area Under Curve; Cell Line, Transformed; Cholinergic Agents; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Isoxazoles; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Receptors, Nicotinic	2009
Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors. Cell calcium, 2009, Volume: 45, Issue:2 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium Signaling; Cell Line, Tumor; Chickens; Electrophysiological Phenomena; Humans; Isoxazoles; Neurons; Nicotine; Phenylurea Compounds; Receptors, Nicotinic; Retinal Ganglion Cells	2009
Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. The European journal of neuroscience, 2009, Volume: 29, Issue:1 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Cyclic AMP-Dependent Protein Kinases; Dentate Gyrus; Isoxazoles; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinase 3; Nicotinic Agonists; Nicotinic Antagonists; Organ Culture Techniques; Phenylurea Compounds; Phosphotransferases; Rats; Rats, Wistar; Receptors, Nicotinic; src-Family Kinases; Synaptic Transmission; Up-Regulation	2009
Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. Glia, 2009, Aug-01, Volume: 57, Issue:10 Topics: Age Factors; Aging; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Antigens; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Hippocampus; Ion Channel Gating; Isoxazoles; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Oligodendroglia; Organ Culture Techniques; Patch-Clamp Techniques; Phenylurea Compounds; Proteoglycans; Receptors, Nicotinic; Stem Cells	2009
Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells. British journal of pharmacology, 2009, Volume: 156, Issue:4 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Calcium; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Isoxazoles; PC12 Cells; Phenylurea Compounds; Phosphorylation; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Signal Transduction	2009
An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. Molecular pharmacology, 2009, Volume: 76, Issue:2 Topics: Acetylcholine; Allosteric Regulation; Animals; Binding Sites; Dose-Response Relationship, Drug; Extracellular Space; Female; Isoxazoles; Ligands; Microinjections; Models, Molecular; Molecular Structure; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, Nicotinic; Xenopus	2009
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors. Biochemical pharmacology, 2009, Oct-01, Volume: 78, Issue:7 Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins; Computer Simulation; Female; Genistein; Humans; Isoxazoles; Ivermectin; Models, Molecular; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Receptors, Nicotinic; Sequence Homology, Amino Acid; Xenopus laevis	2009
Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596. Journal of molecular neuroscience : MN, 2010, Volume: 40, Issue:1-2 Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartic Acid; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamine; Isoxazoles; Microdialysis; Neuronal Plasticity; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Prefrontal Cortex; Presynaptic Terminals; Rats; Receptors, Nicotinic; Synaptic Transmission; Synaptosomes	2010
Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. Assay and drug development technologies, 2009, Volume: 7, Issue:4 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Discovery; Electrophysiology; Female; Humans; Isoxazoles; Neuroblastoma; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Pyridines; Receptors, Nicotinic; Xenopus laevis	2009
Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. Neuropharmacology, 2009, Volume: 56, Issue:4 Topics: Adrenergic alpha-Agonists; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Cloning, Molecular; DNA, Complementary; Evoked Potentials; Hippocampus; Indoles; Interneurons; Isoxazoles; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Pyridinium Compounds; Rats; Receptors, Nicotinic; Synaptic Transmission; Xenopus laevis	2009
Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2 Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Drug Synergism; Female; Hypothalamic Area, Lateral; Isoxazoles; Male; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2010
Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. British journal of pharmacology, 2009, Volume: 158, Issue:8 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Survival; Electrophysiology; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Nicotinic Agonists; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sulfonamides	2009
Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. The European journal of neuroscience, 2010, Volume: 31, Issue:6 Topics: Analysis of Variance; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cells, Cultured; Cholinergic Agents; Dose-Response Relationship, Drug; Female; Humans; Immunoprecipitation; Isoxazoles; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Binding; Protein Subunits; Pyridines; Receptors, Nicotinic; Sodium Channel Blockers; Statistics, Nonparametric; Superior Cervical Ganglion; Tetrodotoxin; Tritium; Xenopus	2010
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107. The Journal of pharmacology and experimental therapeutics, 2010, Sep-01, Volume: 334, Issue:3 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Isoxazoles; Male; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substrate Specificity; Sulfonamides; Xenopus	2010
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Databases, Factual; Humans; Isoxazoles; Microsomes, Liver; Models, Molecular; Phenylurea Compounds; Rats; Receptors, Nicotinic; Structure-Activity Relationship	2010
Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization. Molecular pharmacology, 2010, Volume: 78, Issue:6 Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Binding Sites; Female; Humans; Isoxazoles; Molecular Probes; Molecular Sequence Data; Mutation; Nicotinic Agonists; Oocytes; Phenylurea Compounds; Protein Structure, Tertiary; Receptors, Nicotinic; Xenopus laevis	2010
Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596. PloS one, 2010, Nov-12, Volume: 5, Issue:11 Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Choline; Dose-Response Relationship, Drug; Drug Synergism; Female; Isoxazoles; Male; Nootropic Agents; Patch-Clamp Techniques; Phenylurea Compounds; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2010
Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 123, Issue:1 Topics: alpha7 Nicotinic Acetylcholine Receptor; Azetidines; Benzamides; Bridged Bicyclo Compounds; Calcium; Cell Line, Tumor; Humans; Ionophores; Isoxazoles; Janus Kinase 2; Neuroblastoma; Neurons; Nicotinic Agonists; Okadaic Acid; Phenylurea Compounds; Pyridines; Receptors, Nicotinic; Signal Transduction	2011
The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7nAChR function. Biochemical pharmacology, 2011, Oct-15, Volume: 82, Issue:8* Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cell Line, Tumor; Cloning, Molecular; Electrophysiological Phenomena; Female; Genes, Duplicate; Genetic Linkage; Humans; Isoxazoles; Ligands; Multigene Family; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Binding; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA; Schizophrenia; Smoking; Transfection; Xenopus laevis	2011
Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization. Neuropharmacology, 2011, Volume: 61, Issue:8 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Computer Simulation; Dose-Response Relationship, Drug; Electric Stimulation; Isoxazoles; Membrane Potentials; Microinjections; Models, Molecular; Mutation; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Structure, Tertiary; Receptors, Nicotinic; Xenopus laevis	2011
Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states. Molecular pharmacology, 2011, Volume: 80, Issue:6 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Female; Humans; Isoxazoles; Nicotinic Agonists; Phenylurea Compounds; Protein Stability; Receptors, Nicotinic; Xenopus laevis	2011
Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Sep-28, Volume: 31, Issue:39 Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; HEK293 Cells; Humans; Isoxazoles; Mutation; Neurons; Phenylurea Compounds; Protein Structure, Secondary; Receptors, Nicotinic	2011
Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. PloS one, 2011, Volume: 6, Issue:11 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; GPI-Linked Proteins; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Memory; Memory, Short-Term; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger	2011
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:9 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Brain; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Drug Interactions; Female; Half-Life; Hallucinogens; Isoxazoles; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Phencyclidine; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tissue Distribution	2012
Protective effect of PNU-120596, a selective alpha7 nicotinic acetylcholine receptor-positive allosteric modulator, on myocardial ischemia-reperfusion injury in rats. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cytokines; Disease Models, Animal; Inflammation; Isoxazoles; Lipid Peroxidation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NF-kappa B; Nicotinic Agonists; Phenylurea Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2012
Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596. PloS one, 2012, Volume: 7, Issue:3 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Calcium; Choline; Hippocampus; Interneurons; Ion Channels; Isoxazoles; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2012
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat. British journal of pharmacology, 2012, Volume: 167, Issue:2 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Carrageenan; Cytokines; Diclofenac; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thiophenes	2012
Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor. The Journal of biological chemistry, 2012, Jun-22, Volume: 287, Issue:26 Topics: Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Electrophysiology; Humans; Hydrogen Bonding; Isoxazoles; Ligands; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Mutation; Phenylurea Compounds; Protein Conformation; Receptors, Nicotinic	2012
Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures. Molecular pharmacology, 2012, Volume: 82, Issue:4 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cattle; Cytotoxins; Drug Synergism; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Patch-Clamp Techniques; Phenylurea Compounds; Radioligand Assay; Receptors, Nicotinic; Serum Albumin, Bovine; Temperature; Transfection	2012
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model. British journal of pharmacology, 2013, Volume: 169, Issue:3 Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines	2013
Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models. Neuropharmacology, 2013, Volume: 65 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Disease Models, Animal; Inflammation; Isoxazoles; Male; Mice; Mice, Inbred ICR; Neuralgia; Nicotinic Agonists; Phenylurea Compounds; Receptors, Nicotinic; Treatment Outcome	2013
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Butadienes; Cholinergic Agents; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Injections, Spinal; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Nitriles; Pain; Pain Measurement; Phenylurea Compounds; Physical Stimulation; Postural Balance; Reaction Time; Receptors, Nicotinic	2013
Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates. Neuropharmacology, 2013, Volume: 67 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Drug Therapy, Combination; Female; Indans; Isoxazoles; Learning; Macaca mulatta; Male; Memory; Phenylurea Compounds; Piperidines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Nicotinic; Species Specificity; Treatment Outcome; Up-Regulation	2013
Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist. Neuropharmacology, 2013, Volume: 70 Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Drug Interactions; Isoxazoles; Learning; Male; Memory Disorders; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Piperazines; Rats; Scopolamine; Serotonin 5-HT1 Receptor Antagonists	2013
Stoichiometry for drug potentiation of a pentameric ion channel. Proceedings of the National Academy of Sciences of the United States of America, 2013, Apr-16, Volume: 110, Issue:16 Topics: alpha7 Nicotinic Acetylcholine Receptor; Drug Synergism; HEK293 Cells; Humans; Isoxazoles; Likelihood Functions; Models, Molecular; Mutagenesis; Patch-Clamp Techniques; Phenylurea Compounds; Protein Subunits; Receptors, Nicotinic; Time Factors	2013
A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. British journal of pharmacology, 2013, Volume: 169, Issue:8 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain Ischemia; Choline; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Neurons; Neuroprotective Agents; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley	2013
Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor. Bioorganic & medicinal chemistry letters, 2013, Jul-15, Volume: 23, Issue:14 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Catalysis; Isoxazoles; Oocytes; Palladium; Phenylurea Compounds; Piperidines; Pyridines; Xenopus	2013
Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Molecular pharmacology, 2013, Volume: 84, Issue:3 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Choline; Cytotoxins; Female; Humans; Isoxazoles; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Xenopus laevis	2013
A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats. PloS one, 2013, Volume: 8, Issue:8 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Isoxazoles; Male; Motor Activity; Neuroprotective Agents; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Stroke	2013
The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels. European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Drug Synergism; Female; In Vitro Techniques; Ion Channel Gating; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley	2013
MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry, 2014, Jan-14, Volume: 53, Issue:1 Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Cell Line, Tumor; Conotoxins; Conus Snail; Humans; Isoxazoles; Molecular Sequence Data; Phenylurea Compounds	2014
Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors. Neuropharmacology, 2014, Volume: 81 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biophysics; Cell Line, Tumor; Choline; Computer Simulation; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Isoxazoles; Membrane Potentials; Models, Biological; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pituitary Neoplasms; Rats; Transfection	2014
Kinetic properties and open probability of α7 nicotinic acetylcholine receptors. Neuropharmacology, 2014, Volume: 81 Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biophysical Phenomena; Cell Line, Tumor; Choline; Computer Simulation; Dose-Response Relationship, Drug; Electric Stimulation; Isoxazoles; Membrane Potentials; Models, Biological; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pituitary Neoplasms; Rats; Transfection	2014
Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors. Neurochemical research, 2015, Volume: 40, Issue:10 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Benzamides; Bridged Bicyclo Compounds; Calcium; Cell Line, Tumor; Humans; Isoxazoles; Mice; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Pyridines; Receptors, Nicotinic	2015
Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens. ACS chemical neuroscience, 2014, Oct-15, Volume: 5, Issue:10 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cerebral Cortex; Cholinergic Agents; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Male; Models, Neurological; Neural Pathways; Neurons; Nucleus Accumbens; Phenylurea Compounds; Quinuclidines; Rats, Sprague-Dawley; Synapses; Thiophenes	2014
High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept. Brain research bulletin, 2015, Volume: 112 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Astrocytes; Brain Injuries; Cholinergic Agents; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Male; Neurons; Neuroprotective Agents; Phenylurea Compounds; Rats, Sprague-Dawley	2015
Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum. Journal of neurochemistry, 2015, Volume: 133, Issue:3 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Humans; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley	2015
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits. Brain research, 2015, Jun-22, Volume: 1611 Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline; Disease Models, Animal; Female; Heterozygote; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Transgenic; Phenylurea Compounds; Schizophrenia; Sensory Gating	2015
Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16. Assay and drug development technologies, 2015, Volume: 13, Issue:3 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Automation; Bridged Bicyclo Compounds; Humans; Indazoles; Isoxazoles; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Quinuclidines; Rats; Thiophenes; Tumor Cells, Cultured	2015
Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. PloS one, 2015, Volume: 10, Issue:4 Topics: Aconitine; Cells, Cultured; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Neurons; Phenylurea Compounds; Receptors, Nicotinic; Single-Cell Analysis	2015
Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons. Neuropharmacology, 2015, Volume: 95 Topics: Adenylyl Cyclases; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cells, Cultured; Choline; Cholinergic Agents; Cyclic AMP; Hippocampus; Intracellular Space; Isoxazoles; Mice, Inbred C57BL; Neurons; Phenylurea Compounds; Phosphorylation; Synapsins	2015
Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:8 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Cholinergic Agents; Cognition; Executive Function; Galantamine; Isoxazoles; Male; Motor Activity; Phenylurea Compounds; Rats, Sprague-Dawley; Recognition, Psychology	2015
An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors. Chemistry & biology, 2015, Aug-20, Volume: 22, Issue:8 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Binding Sites; Dose-Response Relationship, Drug; Humans; Isoxazoles; Models, Molecular; Nicotinic Agonists; Phenylurea Compounds; Protein Binding; Protein Structure, Secondary	2015
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. PloS one, 2015, Volume: 10, Issue:9 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Gene Expression; Humans; Isoxazoles; Models, Molecular; Mutation, Missense; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Polymorphism, Single Nucleotide; Protein Structure, Secondary; Protein Structure, Tertiary; Quinolines; Sulfonamides; Transgenes; Xenopus laevis	2015
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION. The Journal of biological chemistry, 2016, Mar-04, Volume: 291, Issue:10 Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Sequence Data; Nicotinic Agonists; Phenylurea Compounds; Quinolines; Sulfonamides; Xenopus	2016
Subtype-selective nicotinic acetylcholine receptor agonists can improve cognitive flexibility in an attentional set shifting task. Neuropharmacology, 2016, Volume: 105 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Bridged Bicyclo Compounds, Heterocyclic; Choice Behavior; Cognition; Discrimination, Psychological; Isoxazoles; Male; Nicotine; Nicotinic Agonists; Phenylurea Compounds; Rats; Receptors, Nicotinic	2016
Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO. Neuron, 2016, Mar-02, Volume: 89, Issue:5 Topics: Acetylcholine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calnexin; Glial Fibrillary Acidic Protein; Glutamic Acid; HEK293 Cells; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Membrane Proteins; Mice; Microtubule-Associated Proteins; Neurons; Phenylurea Compounds; Protein Subunits; RNA, Small Interfering; Serotonin	2016
Boosting Endogenous Resistance of Brain to Ischemia. Molecular neurobiology, 2017, Volume: 54, Issue:3 Topics: Administration, Intravenous; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylamines; Brain; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dose-Response Relationship, Drug; Infusions, Intraventricular; Isoxazoles; Male; Organ Culture Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Sulfonamides	2017
Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity. Neuropharmacology, 2016, Volume: 105 Topics: Acetylcholine; Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cholinergic Agents; Cholinesterase Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Long-Term Potentiation; Male; Membrane Potentials; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Prefrontal Cortex; Tissue Culture Techniques	2016
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective. Neuropharmacology, 2016, Volume: 107 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cations, Divalent; Cell Line; Cholinergic Agents; Humans; Isoxazoles; Kinetics; Membrane Potentials; Models, Molecular; Mutation; Patch-Clamp Techniques; Phenylurea Compounds; Protein Conformation; Rats; Temperature; Transfection	2016
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists. ACS chemical neuroscience, 2016, 08-17, Volume: 7, Issue:8 Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line, Tumor; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Isoxazoles; Membrane Potentials; Microinjections; Neuroblastoma; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Piperidines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin; Xenopus laevis	2016
Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli. The Journal of biological chemistry, 2016, 08-26, Volume: 291, Issue:35 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Escherichia coli; Escherichia coli Proteins; Humans; Isoxazoles; Lidocaine; Molecular Chaperones; Phencyclidine; Phenylurea Compounds; Recombinant Proteins; Xenopus	2016
Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 07-20, Volume: 36, Issue:29 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Central Nervous System Depressants; Cholinergic Agents; Cholinesterases; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Lysine; Male; Motor Disorders; Neurotransmitter Agents; Phenylurea Compounds; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Potentials	2016
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats. Neuropharmacology, 2016, Volume: 111 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Anilides; Animals; Choline; Excitatory Amino Acid Agonists; Glutamic Acid; Isoxazoles; Male; N-Methylaspartate; Nucleus Accumbens; Phenylurea Compounds; Prefrontal Cortex; Rats; Rats, Wistar	2016
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017, Apr-01, Volume: 19, Issue:4 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds, Heterocyclic; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Isoxazoles; Male; Mice; Mice, Knockout; Phenylurea Compounds; Quinuclidines	2017
Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:8 Topics: Animals; Cocaine; Dopamine; Isoxazoles; Kynurenic Acid; Male; Nicotine; Nucleus Accumbens; Phenylurea Compounds; Rats; Recurrence; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Sulfonamides; Thiazoles	2017
Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats. Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:2 Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Cognition; Cognitive Dysfunction; Dizocilpine Maleate; Isoxazoles; Male; Memory Disorders; Memory, Short-Term; Nicotinic Agonists; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Sensory Gating	2017
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters, 2018, Sep-01, Volume: 293 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Isoxazoles; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pyridinium Compounds; Structure-Activity Relationship	2018
Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific reports, 2017, 11-30, Volume: 7, Issue:1 Topics: Allosteric Regulation; Amino Acid Sequence; Antigens, Ly; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Muscles; Neurons; Phenylurea Compounds; Protein Binding; Protein Conformation; Protein Multimerization; Receptors, Nicotinic; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Urokinase-Type Plasminogen Activator	2017
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. Toxicology letters, 2018, Sep-01, Volume: 293 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CHO Cells; Cholinesterase Reactivators; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Isoxazoles; Nicotinic Agonists; Organophosphate Poisoning; Patch-Clamp Techniques; Phenylurea Compounds; Pyridinium Compounds; Structure-Activity Relationship	2018
Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of Molecular pharmacology, 2018, Volume: 93, Issue:6 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Calcium Signaling; Cell Line, Tumor; Cytoplasm; GTP-Binding Proteins; Humans; Isoxazoles; PC12 Cells; Phenylurea Compounds; Rats	2018
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice. Progress in neuro-psychopharmacology & biological psychiatry, 2018, 08-30, Volume: 86 Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cholinergic Agents; Depressive Disorder; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Motor Activity; Phenylurea Compounds; Prefrontal Cortex	2018
Treatment duration affects cytoprotective efficacy of positive allosteric modulation of α7 nAChRs after focal ischemia in rats. Pharmacological research, 2018, Volume: 136 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Drug Administration Schedule; Infarction, Middle Cerebral Artery; Isoxazoles; Male; Neuroprotective Agents; Nicotinic Agonists; Phenylurea Compounds; Rats, Sprague-Dawley	2018
Perioperative activation of spinal α7 nAChR promotes recovery from preoperative stress-induced prolongation of postsurgical pain. Brain, behavior, and immunity, 2019, Volume: 79 Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anxiety; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Chronic Pain; Cytokines; Hyperalgesia; Isoxazoles; Male; Microglia; Nicotinic Agonists; Phenylurea Compounds; Preoperative Period; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spine; Stress, Psychological	2019
Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice. Behavioural brain research, 2019, 07-02, Volume: 366 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Astrocytes; Cognition; Cognition Disorders; Cognitive Dysfunction; Cytokines; Depression; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Phenylurea Compounds; Prefrontal Cortex	2019
Allosteric Agonism of Molecular pharmacology, 2019, Volume: 95, Issue:6 Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Cell Line; Humans; Isoxazoles; Male; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Nicotinic Agonists; Phenylurea Compounds; Piperazines; Quinolines; Sulfonamides; Xenopus laevis	2019
Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. British journal of pharmacology, 2019, Volume: 176, Issue:18 Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; HEK293 Cells; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Pyridines; Pyridinium Compounds; Quinuclidines; Thiophenes	2019
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for α7 nAChRs. Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Computer Simulation; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Neurotransmitter Agents; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Structure-Activity Relationship; Xenopus laevis	2019
Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons. Stem cell research, 2019, Volume: 41 Topics: alpha7 Nicotinic Acetylcholine Receptor; Calcium Signaling; Cell Differentiation; Cell Line; Humans; Induced Pluripotent Stem Cells; Isoxazoles; MAP Kinase Signaling System; Nerve Net; Neurons; Phenylurea Compounds; Synaptic Transmission	2019
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats. Behavioural brain research, 2020, 05-15, Volume: 385 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Galantamine; Isoxazoles; Memantine; Nootropic Agents; Phenylurea Compounds; Rats; Recognition, Psychology; Scopolamine	2020
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats. Pharmacology, biochemistry, and behavior, 2020, Volume: 193 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome	2020
PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea stagnalis. Journal of neurochemistry, 2020, Volume: 155, Issue:3 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Cells, Cultured; Chloride Channels; Female; Humans; Isoxazoles; Ligand-Gated Ion Channels; Lymnaea; PC12 Cells; Phenylurea Compounds; Rats; Rats, Wistar; Xenopus laevis	2020
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats. Behavioural brain research, 2021, 01-15, Volume: 397 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia	2021
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK. Biochemical pharmacology, 2020, Volume: 182 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Humans; Isoxazoles; MCF-7 Cells; Mice; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Protein Kinase Inhibitors	2020
The α7 nAChR allosteric modulator PNU-120596 amends neuroinflammatory and motor consequences of parkinsonism in rats: Role of JAK2/NF-κB/GSk3β/ TNF-α pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 148 Topics: Animals; Dopaminergic Neurons; Glycogen Synthase Kinase 3 beta; Hypokinesia; Isoxazoles; Janus Kinase 2; Neuroinflammatory Diseases; NF-kappa B; Oxidopamine; Parkinsonian Disorders; Phenylurea Compounds; Random Allocation; Rats; Tumor Necrosis Factor-alpha	2022
Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators. Proceedings of the National Academy of Sciences of the United States of America, 2022, 10-25, Volume: 119, Issue:43 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Cholesterol; Humans; Isoxazoles; Ligand-Gated Ion Channels; Ligands; Lipids; Phenylurea Compounds; Receptors, Nicotinic	2022
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596. Bioorganic & medicinal chemistry letters, 2023, 09-01, Volume: 93 Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Hippocampus; Isoxazoles; Phenylurea Compounds; Rats; Receptors, Nicotinic	2023