isoxazoles has been researched along with pnu 120596 in 94 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 16 (17.02) | 29.6817 |
2010's | 70 (74.47) | 24.3611 |
2020's | 8 (8.51) | 2.80 |
Authors | Studies |
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Allaman, G; Arneric, SP; Berkenpas, MB; Bertrand, D; Bertrand, S; Groppi, VE; Hajós, M; Higdon, NR; Hoffmann, WE; Hurst, RS; Lawson, JA; Ogier, R; Piotrowski, DW; Raggenbass, M; Rutherford-Root, KL; Wall, TM | 1 |
Briggs, CA; Gopalakrishnan, M; Grønlien, JH; Håkerud, M; Malysz, J; Thorin-Hagene, K; Ween, H | 1 |
Bothmann, H; Dunlop, J; Jow, B; Jow, F; Kramer, A; Papini, S; Roncarati, R; Seredenina, T; Terstappen, GC | 1 |
Hone, A; Innocent, N; Kimura, A; Livingstone, PD; McIntosh, JM; Whiteaker, P; Wonnacott, S; Young, T | 1 |
Millar, NS; Sher, E; Walker, AS; Young, GT; Zwart, R | 1 |
Bowlby, MR; Dunlop, J; Friis, S; Mathes, C; Sunesen, M | 1 |
Beach, JW; Buccafusco, JJ; Terry, AV | 1 |
Arnaudeau, S; Bertrand, D; Demaurex, N; Gilbert, D; Lecchi, M | 1 |
Anwyl, R; Rowan, MJ; Welsby, PJ | 1 |
Angulo, MC; Audinat, E; Vélez-Fort, M | 1 |
Anderson, DJ; El Kouhen, R; Gopalakrishnan, M; Hu, M; Li, J | 1 |
Barron, SC; McLaughlin, JT; Richards, VL; Rosenberg, RL; See, JA | 1 |
Akamatsu, M; Almond, A; Blundell, CD; Buckingham, SD; Jones, AK; Matsuda, K; Pienaar, I; Pienaar, IS; Sattelle, BM; Sattelle, DB | 1 |
Dickinson, JA; Kew, JN; Livingstone, PD; Srinivasan, J; Wonnacott, S | 1 |
Ahring, PK; Briggs, CA; Dyhring, T; Gopalakrishnan, M; Grønlien, JH; Håkerud, M; Malysz, J; Thorin-Hagene, K; Timmermann, DB; Trumbull, JD; Ween, H; Xiong, Y | 1 |
Kem, WR; López-Hernández, GY; Morain, P; Papke, RL; Soti, F; Thinschmidt, JS; Trocme-Thibierge, C | 1 |
Gusev, AG; Uteshev, VV | 1 |
Gopalakrishnan, M; Hu, M; Li, J | 1 |
Ciuraszkiewicz, A; David, R; Huck, S; McIntosh, JM; Orr-Urtreger, A; Papke, RL; Scholze, P; Simeone, X | 1 |
Ahring, PK; Anderson, DJ; Briggs, CA; Bunnelle, WH; Dyhring, T; Gopalakrishnan, M; Gopalakrishnan, S; Grønlien, JH; Gubbins, E; Håkerud, M; Helfrich, R; Hu, M; Ji, J; Li, J; Malysz, J; Meyer, MD; Nielsen, EØ; Peters, D; Puttfarcken, PS; Thorin-Hagene, K; Timmermann, DB; Ween, H | 1 |
Capelli, AM; Castelletti, L; Di Lenarda, E; Kew, JN; Lightfoot, A; Oliosi, B; Salvagno, C; Teague, S; Virginio, C | 1 |
Horenstein, NA; Papke, RL; Stokes, C; Wang, J | 2 |
Gusev, AG; Kalappa, BI; Uteshev, VV | 1 |
Avila, J; Del Barrio, L; Egea, J; López, MG; Martín-de-Saavedra, MD; McIntosh, JM; Parada, E; Romero, A; Wonnacott, S | 1 |
Araud, T; Berger, R; Bertrand, D; Graw, S; Lee, M; Leonard, S; Neveu, E | 1 |
Collins, T; Millar, NS; Young, GT | 1 |
Papke, RL; Wang, J; Williams, DK | 1 |
Bouzat, C; Corradi, J; daCosta, CJ; Free, CR; Sine, SM | 1 |
El-Sayed, M; Mikkelsen, JD; Thomsen, MS | 1 |
Gendle, DF; Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ | 1 |
He, XH; Li, H; Song, XM; Wang, YL; Zhan, J; Zhang, ZZ | 1 |
Uteshev, VV | 2 |
Christensen, J; Erichsen, H; Hansen, H; Hansen, R; Munro, G; Timmermann, D | 1 |
Kimbrell, MR; Papke, RL; Peng, C; Williams, DK | 1 |
Carroll, FI; Damaj, MI; Freitas, K; Negus, SS | 1 |
Freitas, K; Ghosh, S; Imad Damaj, M; Ivy Carroll, F; Lichtman, AH | 1 |
Carroll, FI; Damaj, MI; Freitas, K | 1 |
Callahan, PM; Chapman, JM; Hutchings, EJ; Kille, NJ; Terry, AV | 1 |
Pandya, AA; Yakel, JL | 1 |
daCosta, CJ; Sine, SM | 1 |
Jin, K; Johnson, SR; Kalappa, BI; Sun, F; Uteshev, VV | 1 |
Chojnacka, K; Horenstein, NA; Papke, RL | 1 |
Crooks, PA; Fifer, EK; Kimbrell, MR; Pack, TF; Papke, RL; Peng, C; Tian, C | 1 |
Jin, K; Sun, F; Uteshev, VV | 1 |
Kalappa, BI; Uteshev, VV | 1 |
Abraham, N; Alewood, PF; Christie, MJ; Dutertre, S; Emidio, NB; Inserra, M; Jin, AH; Lewis, RJ; Murali, SS; Vetter, I | 1 |
Mike, A; Pesti, K; Szabo, AK; Vizi, ES | 2 |
Brown, JL; Wonnacott, S | 1 |
Bencherif, M; Budygin, E; Grinevich, V; Grinevich, VP; Gutkin, B; Maex, R | 1 |
Gatson, JW; Simpkins, JW; Uteshev, VV | 1 |
Cano-Abad, MF; Egea, J; Fernández-Morales, JC; Guerra-Álvarez, M; López, MG; Moreno-Ortega, AJ; Navarro, E | 1 |
Floyd, KL; Stevens, KE; Stitzel, JA; Zheng, L | 1 |
Hao, Y; Tang, J; Wang, K | 1 |
Chatzidaki, A; Dage, J; Fouillet, A; Li, J; Millar, NS; Sher, E; Ursu, D | 1 |
Cheng, Q; Yakel, JL | 1 |
Kos, T; Nikiforuk, A; Popik, P; Potasiewicz, A | 1 |
Dougherty, DA; Lester, HA; Marotta, CB | 1 |
Chang, Y; Du, Y; Guo, C; Huang, Y; Lukas, RJ; Xu, X; Xue, F; Zhang, J; Zhang, Q | 1 |
Chaturbhuj, GU; Horenstein, NA; Kulkarni, AR; Manther, K; Papke, RL; Stokes, C; Thakur, GA | 1 |
Allison, C; Kohli, S; Malcolm, E; Shoaib, M; Wood, C | 1 |
Bredt, DS; Davini, WB; Gu, S; Harrington, AW; Lord, B; Matta, JA; Sutton, SW | 1 |
Jin, K; Johnson, SR; Sun, F; Uteshev, VV | 1 |
Bailey, CP; Udakis, M; Wonnacott, S; Wright, VL | 1 |
Andersen, ND; Arias, HR; Bouzat, C; Corradi, J; Feuerbach, D; Nielsen, BE; Tolosa, MF | 1 |
Bautista-Aguilera, OM; Chioua, M; Colmena, I; Criado, M; Gandía, L; Marco-Contelles, J; Mulet, J; Sala, F; Sala, S; Samadi, A | 1 |
Alvarez, FJ; Liu, C; Reinert, NJ; Tang, P; Tillman, TS; Wang, D; Xiao, K; Xu, Y; Zhang, P | 1 |
Abburi, C; Gallagher, K; McDaid, J; McGehee, DS; Wolfman, SL | 1 |
Bortz, DM; Bruno, JP; Mikkelsen, JD; Upton, BA | 1 |
Akbarali, HI; AlSharari, SD; Bagdas, D; Cabral, GA; Carroll, FI; Damaj, MI; Lichtman, PA; McGee, EA; Raborn, ES | 1 |
Auber, A; Goldberg, SR; Justinova, Z; Panlilio, LV; Redhi, GH; Schindler, CW; Schwarcz, R; Secci, ME; Thorndike, EB | 1 |
Hołuj, M; Nikiforuk, A; Popik, P; Potasiewicz, A | 1 |
Niessen, KV; Rappenglück, S; Scheffel, C; Seeger, T; Thiermann, H; Wanner, KT; Worek, F | 2 |
Adams, DJ; Corringer, PJ; Craik, DJ; Durek, T; Faure, G; Kasheverov, IE; Kudryavtsev, DS; Shelukhina, IV; Spirova, EN; Tae, HS; Thongyoo, P; Tsetlin, VI | 1 |
Bak, E; Jafri, MS; Kabbani, N; King, JR; Ullah, A | 1 |
Alzarea, S; Rahman, S | 2 |
Gaidhani, N; Uteshev, VV | 1 |
Bo, J; Gu, X; Hou, B; Huo, W; Lei, Y; Liu, Y; Liu, Z; Ma, Z; Mao, Y; Sun, R; Sun, Y; Zhang, W; Zhang, Y; Zhang, Z | 1 |
Garai, S; Gulsevin, A; Horenstein, NA; Papke, RL; Quadri, M; Stokes, C; Thakur, GA | 1 |
Cecon, E; Chollet, AM; Dam, J; Danober, L; Delagrange, P; Gautier, C; Jockers, R; Luka, M | 1 |
Brandao-Araiza, S; Camacho-Hernandez, GA; Doan, L; Duggan, BM; Kaczanowska, K; Papke, RL; Stokes, C; Taylor, P | 1 |
Hansen, SK; Hyttel, P; Larsen, HM; Mikkelsen, JD; Stummann, TC | 1 |
Gzielo, K; Krawczyk, M; Nikiforuk, A; Popik, P; Potasiewicz, A | 1 |
Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB | 1 |
Kolbaev, SN; Kryukova, EV; Kudryavtsev, DS; Lebedev, DS; Tsetlin, VI; Utkin, YN; Vulfius, CA | 1 |
Aricioglu, F; Sirvanci, S; Unal, G | 1 |
Islam, MS; Mikami, D; Muramatsu, I; Nakazawa, H; Taniguchi, T; Uwada, J; Yazawa, T | 1 |
Afify, EA; El-Ganainy, SO; El-Sayed, NS; Gowayed, MA; Matar, NA | 1 |
Hibbs, RE; Howard, RJ; Lindahl, E; Noviello, CM; Zhuang, Y | 1 |
Acker, BA; Badescu, VO; Berkenpas, MB; Groppi, VE; Hajós, M; Higdon, NR; Hurst, RS; Jon Jacobsen, E; Margolis, BJ; McWhorter, WW; Myers, JK; Piotrowski, DW; Rogers, BN; Sarapa, D; Vetman, TN; Walker, DP; Wall, TM; Wilhite, DM; Wishka, DG; Xu, W; Yates, KM | 1 |
2 review(s) available for isoxazoles and pnu 120596
Article | Year |
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Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.
Topics: Allosteric Regulation; Animals; Binding Sites; Choline; Drug Design; Humans; Isoxazoles; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Piperazines; Pyridines; Rats; Receptors, Nicotinic | 2009 |
α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2012 |
92 other study(ies) available for isoxazoles and pnu 120596
Article | Year |
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A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.
Topics: Acetylcholine; Acoustic Stimulation; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Amphetamine; Animals; Animals, Newborn; Calcium; Cell Line; Central Nervous System Stimulants; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Epithelial Cells; Evoked Potentials, Auditory; Hippocampus; Humans; In Vitro Techniques; Isoxazoles; Male; Membrane Potentials; Microinjections; Neurons; Nicotine; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tetrodotoxin; Time Factors; Xenopus | 2005 |
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Benzylidene Compounds; Bridged Bicyclo Compounds; Calcium; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genistein; Humans; Indoles; Isoxazoles; Kidney; Microinjections; Naphthalenes; Nicotine; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein-Tyrosine Kinases; Pyridines; Quinolines; Receptors, Cholinergic; Receptors, Nicotinic; Sensitivity and Specificity; Sulfonamides; Xenopus laevis | 2007 |
Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; CHO Cells; Cricetinae; Cricetulus; Electrophysiology; Enzyme Inhibitors; Fluorescent Dyes; Genistein; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Kinetics; Microscopy, Fluorescence; Nicotinic Agonists; Phenylurea Compounds; Receptors, Nicotinic; Recombinant Proteins; RNA; Transfection | 2008 |
Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Calcium; Choline; Conotoxins; Dopamine; Humans; Isoxazoles; Male; Nicotinic Antagonists; PC12 Cells; Phenylurea Compounds; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spiro Compounds | 2008 |
Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Amino Acids; Animals; Binding Sites; Chickens; Computer Simulation; Dose-Response Relationship, Drug; Humans; Isoxazoles; Mice; Models, Molecular; Mutant Chimeric Proteins; Mutation; Oocytes; Phenylurea Compounds; Protein Structure, Tertiary; Rats; Receptors, Nicotinic; Xenopus laevis | 2008 |
Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Area Under Curve; Cell Line, Transformed; Cholinergic Agents; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Isoxazoles; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Receptors, Nicotinic | 2009 |
Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium Signaling; Cell Line, Tumor; Chickens; Electrophysiological Phenomena; Humans; Isoxazoles; Neurons; Nicotine; Phenylurea Compounds; Receptors, Nicotinic; Retinal Ganglion Cells | 2009 |
Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Cyclic AMP-Dependent Protein Kinases; Dentate Gyrus; Isoxazoles; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinase 3; Nicotinic Agonists; Nicotinic Antagonists; Organ Culture Techniques; Phenylurea Compounds; Phosphotransferases; Rats; Rats, Wistar; Receptors, Nicotinic; src-Family Kinases; Synaptic Transmission; Up-Regulation | 2009 |
Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus.
Topics: Age Factors; Aging; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Antigens; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Hippocampus; Ion Channel Gating; Isoxazoles; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Oligodendroglia; Organ Culture Techniques; Patch-Clamp Techniques; Phenylurea Compounds; Proteoglycans; Receptors, Nicotinic; Stem Cells | 2009 |
Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Calcium; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Isoxazoles; PC12 Cells; Phenylurea Compounds; Phosphorylation; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Signal Transduction | 2009 |
An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.
Topics: Acetylcholine; Allosteric Regulation; Animals; Binding Sites; Dose-Response Relationship, Drug; Extracellular Space; Female; Isoxazoles; Ligands; Microinjections; Models, Molecular; Molecular Structure; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, Nicotinic; Xenopus | 2009 |
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.
Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins; Computer Simulation; Female; Genistein; Humans; Isoxazoles; Ivermectin; Models, Molecular; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Receptors, Nicotinic; Sequence Homology, Amino Acid; Xenopus laevis | 2009 |
Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartic Acid; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamine; Isoxazoles; Microdialysis; Neuronal Plasticity; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Prefrontal Cortex; Presynaptic Terminals; Rats; Receptors, Nicotinic; Synaptic Transmission; Synaptosomes | 2010 |
Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Discovery; Electrophysiology; Female; Humans; Isoxazoles; Neuroblastoma; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Pyridines; Receptors, Nicotinic; Xenopus laevis | 2009 |
Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795.
Topics: Adrenergic alpha-Agonists; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Cloning, Molecular; DNA, Complementary; Evoked Potentials; Hippocampus; Indoles; Interneurons; Isoxazoles; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Pyridinium Compounds; Rats; Receptors, Nicotinic; Synaptic Transmission; Xenopus laevis | 2009 |
Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Drug Synergism; Female; Hypothalamic Area, Lateral; Isoxazoles; Male; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2010 |
Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Survival; Electrophysiology; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Nicotinic Agonists; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sulfonamides | 2009 |
Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cells, Cultured; Cholinergic Agents; Dose-Response Relationship, Drug; Female; Humans; Immunoprecipitation; Isoxazoles; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Binding; Protein Subunits; Pyridines; Receptors, Nicotinic; Sodium Channel Blockers; Statistics, Nonparametric; Superior Cervical Ganglion; Tetrodotoxin; Tritium; Xenopus | 2010 |
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Isoxazoles; Male; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substrate Specificity; Sulfonamides; Xenopus | 2010 |
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Databases, Factual; Humans; Isoxazoles; Microsomes, Liver; Models, Molecular; Phenylurea Compounds; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2010 |
Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Binding Sites; Female; Humans; Isoxazoles; Molecular Probes; Molecular Sequence Data; Mutation; Nicotinic Agonists; Oocytes; Phenylurea Compounds; Protein Structure, Tertiary; Receptors, Nicotinic; Xenopus laevis | 2010 |
Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Choline; Dose-Response Relationship, Drug; Drug Synergism; Female; Isoxazoles; Male; Nootropic Agents; Patch-Clamp Techniques; Phenylurea Compounds; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2010 |
Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Azetidines; Benzamides; Bridged Bicyclo Compounds; Calcium; Cell Line, Tumor; Humans; Ionophores; Isoxazoles; Janus Kinase 2; Neuroblastoma; Neurons; Nicotinic Agonists; Okadaic Acid; Phenylurea Compounds; Pyridines; Receptors, Nicotinic; Signal Transduction | 2011 |
The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cell Line, Tumor; Cloning, Molecular; Electrophysiological Phenomena; Female; Genes, Duplicate; Genetic Linkage; Humans; Isoxazoles; Ligands; Multigene Family; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Binding; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA; Schizophrenia; Smoking; Transfection; Xenopus laevis | 2011 |
Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Computer Simulation; Dose-Response Relationship, Drug; Electric Stimulation; Isoxazoles; Membrane Potentials; Microinjections; Models, Molecular; Mutation; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Protein Structure, Tertiary; Receptors, Nicotinic; Xenopus laevis | 2011 |
Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Female; Humans; Isoxazoles; Nicotinic Agonists; Phenylurea Compounds; Protein Stability; Receptors, Nicotinic; Xenopus laevis | 2011 |
Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; HEK293 Cells; Humans; Isoxazoles; Mutation; Neurons; Phenylurea Compounds; Protein Structure, Secondary; Receptors, Nicotinic | 2011 |
Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; GPI-Linked Proteins; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Memory; Memory, Short-Term; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger | 2011 |
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Brain; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Drug Interactions; Female; Half-Life; Hallucinogens; Isoxazoles; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Phencyclidine; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tissue Distribution | 2012 |
Protective effect of PNU-120596, a selective alpha7 nicotinic acetylcholine receptor-positive allosteric modulator, on myocardial ischemia-reperfusion injury in rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cytokines; Disease Models, Animal; Inflammation; Isoxazoles; Lipid Peroxidation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NF-kappa B; Nicotinic Agonists; Phenylurea Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2012 |
Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Calcium; Choline; Hippocampus; Interneurons; Ion Channels; Isoxazoles; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2012 |
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Carrageenan; Cytokines; Diclofenac; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thiophenes | 2012 |
Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor.
Topics: Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Electrophysiology; Humans; Hydrogen Bonding; Isoxazoles; Ligands; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Mutation; Phenylurea Compounds; Protein Conformation; Receptors, Nicotinic | 2012 |
Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cattle; Cytotoxins; Drug Synergism; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Patch-Clamp Techniques; Phenylurea Compounds; Radioligand Assay; Receptors, Nicotinic; Serum Albumin, Bovine; Temperature; Transfection | 2012 |
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines | 2013 |
Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Disease Models, Animal; Inflammation; Isoxazoles; Male; Mice; Mice, Inbred ICR; Neuralgia; Nicotinic Agonists; Phenylurea Compounds; Receptors, Nicotinic; Treatment Outcome | 2013 |
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Butadienes; Cholinergic Agents; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Injections, Spinal; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Nitriles; Pain; Pain Measurement; Phenylurea Compounds; Physical Stimulation; Postural Balance; Reaction Time; Receptors, Nicotinic | 2013 |
Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Drug Therapy, Combination; Female; Indans; Isoxazoles; Learning; Macaca mulatta; Male; Memory; Phenylurea Compounds; Piperidines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Nicotinic; Species Specificity; Treatment Outcome; Up-Regulation | 2013 |
Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Drug Interactions; Isoxazoles; Learning; Male; Memory Disorders; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Piperazines; Rats; Scopolamine; Serotonin 5-HT1 Receptor Antagonists | 2013 |
Stoichiometry for drug potentiation of a pentameric ion channel.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Drug Synergism; HEK293 Cells; Humans; Isoxazoles; Likelihood Functions; Models, Molecular; Mutagenesis; Patch-Clamp Techniques; Phenylurea Compounds; Protein Subunits; Receptors, Nicotinic; Time Factors | 2013 |
A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain Ischemia; Choline; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Neurons; Neuroprotective Agents; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley | 2013 |
Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Catalysis; Isoxazoles; Oocytes; Palladium; Phenylurea Compounds; Piperidines; Pyridines; Xenopus | 2013 |
Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Choline; Cytotoxins; Female; Humans; Isoxazoles; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Xenopus laevis | 2013 |
A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Isoxazoles; Male; Motor Activity; Neuroprotective Agents; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Stroke | 2013 |
The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Drug Synergism; Female; In Vitro Techniques; Ion Channel Gating; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley | 2013 |
MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Cell Line, Tumor; Conotoxins; Conus Snail; Humans; Isoxazoles; Molecular Sequence Data; Phenylurea Compounds | 2014 |
Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biophysics; Cell Line, Tumor; Choline; Computer Simulation; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Isoxazoles; Membrane Potentials; Models, Biological; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pituitary Neoplasms; Rats; Transfection | 2014 |
Kinetic properties and open probability of α7 nicotinic acetylcholine receptors.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biophysical Phenomena; Cell Line, Tumor; Choline; Computer Simulation; Dose-Response Relationship, Drug; Electric Stimulation; Isoxazoles; Membrane Potentials; Models, Biological; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pituitary Neoplasms; Rats; Transfection | 2014 |
Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Benzamides; Bridged Bicyclo Compounds; Calcium; Cell Line, Tumor; Humans; Isoxazoles; Mice; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Pyridines; Receptors, Nicotinic | 2015 |
Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cerebral Cortex; Cholinergic Agents; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Male; Models, Neurological; Neural Pathways; Neurons; Nucleus Accumbens; Phenylurea Compounds; Quinuclidines; Rats, Sprague-Dawley; Synapses; Thiophenes | 2014 |
High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Astrocytes; Brain Injuries; Cholinergic Agents; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Male; Neurons; Neuroprotective Agents; Phenylurea Compounds; Rats, Sprague-Dawley | 2015 |
Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Humans; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley | 2015 |
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline; Disease Models, Animal; Female; Heterozygote; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Transgenic; Phenylurea Compounds; Schizophrenia; Sensory Gating | 2015 |
Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Automation; Bridged Bicyclo Compounds; Humans; Indazoles; Isoxazoles; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Quinuclidines; Rats; Thiophenes; Tumor Cells, Cultured | 2015 |
Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
Topics: Aconitine; Cells, Cultured; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Neurons; Phenylurea Compounds; Receptors, Nicotinic; Single-Cell Analysis | 2015 |
Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.
Topics: Adenylyl Cyclases; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cells, Cultured; Choline; Cholinergic Agents; Cyclic AMP; Hippocampus; Intracellular Space; Isoxazoles; Mice, Inbred C57BL; Neurons; Phenylurea Compounds; Phosphorylation; Synapsins | 2015 |
Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Cholinergic Agents; Cognition; Executive Function; Galantamine; Isoxazoles; Male; Motor Activity; Phenylurea Compounds; Rats, Sprague-Dawley; Recognition, Psychology | 2015 |
An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Binding Sites; Dose-Response Relationship, Drug; Humans; Isoxazoles; Models, Molecular; Nicotinic Agonists; Phenylurea Compounds; Protein Binding; Protein Structure, Secondary | 2015 |
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Gene Expression; Humans; Isoxazoles; Models, Molecular; Mutation, Missense; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Polymorphism, Single Nucleotide; Protein Structure, Secondary; Protein Structure, Tertiary; Quinolines; Sulfonamides; Transgenes; Xenopus laevis | 2015 |
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.
Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Sequence Data; Nicotinic Agonists; Phenylurea Compounds; Quinolines; Sulfonamides; Xenopus | 2016 |
Subtype-selective nicotinic acetylcholine receptor agonists can improve cognitive flexibility in an attentional set shifting task.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Bridged Bicyclo Compounds, Heterocyclic; Choice Behavior; Cognition; Discrimination, Psychological; Isoxazoles; Male; Nicotine; Nicotinic Agonists; Phenylurea Compounds; Rats; Receptors, Nicotinic | 2016 |
Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO.
Topics: Acetylcholine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calnexin; Glial Fibrillary Acidic Protein; Glutamic Acid; HEK293 Cells; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Membrane Proteins; Mice; Microtubule-Associated Proteins; Neurons; Phenylurea Compounds; Protein Subunits; RNA, Small Interfering; Serotonin | 2016 |
Boosting Endogenous Resistance of Brain to Ischemia.
Topics: Administration, Intravenous; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylamines; Brain; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dose-Response Relationship, Drug; Infusions, Intraventricular; Isoxazoles; Male; Organ Culture Techniques; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Sulfonamides | 2017 |
Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity.
Topics: Acetylcholine; Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cholinergic Agents; Cholinesterase Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Long-Term Potentiation; Male; Membrane Potentials; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Phenylurea Compounds; Prefrontal Cortex; Tissue Culture Techniques | 2016 |
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cations, Divalent; Cell Line; Cholinergic Agents; Humans; Isoxazoles; Kinetics; Membrane Potentials; Models, Molecular; Mutation; Patch-Clamp Techniques; Phenylurea Compounds; Protein Conformation; Rats; Temperature; Transfection | 2016 |
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line, Tumor; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Isoxazoles; Membrane Potentials; Microinjections; Neuroblastoma; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Piperidines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin; Xenopus laevis | 2016 |
Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Escherichia coli; Escherichia coli Proteins; Humans; Isoxazoles; Lidocaine; Molecular Chaperones; Phencyclidine; Phenylurea Compounds; Recombinant Proteins; Xenopus | 2016 |
Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Central Nervous System Depressants; Cholinergic Agents; Cholinesterases; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Lysine; Male; Motor Disorders; Neurotransmitter Agents; Phenylurea Compounds; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Potentials | 2016 |
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Anilides; Animals; Choline; Excitatory Amino Acid Agonists; Glutamic Acid; Isoxazoles; Male; N-Methylaspartate; Nucleus Accumbens; Phenylurea Compounds; Prefrontal Cortex; Rats; Rats, Wistar | 2016 |
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds, Heterocyclic; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Isoxazoles; Male; Mice; Mice, Knockout; Phenylurea Compounds; Quinuclidines | 2017 |
Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys.
Topics: Animals; Cocaine; Dopamine; Isoxazoles; Kynurenic Acid; Male; Nicotine; Nucleus Accumbens; Phenylurea Compounds; Rats; Recurrence; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Sulfonamides; Thiazoles | 2017 |
Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats.
Topics: Acetylcholine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Cognition; Cognitive Dysfunction; Dizocilpine Maleate; Isoxazoles; Male; Memory Disorders; Memory, Short-Term; Nicotinic Agonists; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Sensory Gating | 2017 |
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Isoxazoles; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Pyridinium Compounds; Structure-Activity Relationship | 2018 |
Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.
Topics: Allosteric Regulation; Amino Acid Sequence; Antigens, Ly; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Muscles; Neurons; Phenylurea Compounds; Protein Binding; Protein Conformation; Protein Multimerization; Receptors, Nicotinic; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Urokinase-Type Plasminogen Activator | 2017 |
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CHO Cells; Cholinesterase Reactivators; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Isoxazoles; Nicotinic Agonists; Organophosphate Poisoning; Patch-Clamp Techniques; Phenylurea Compounds; Pyridinium Compounds; Structure-Activity Relationship | 2018 |
Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Calcium Signaling; Cell Line, Tumor; Cytoplasm; GTP-Binding Proteins; Humans; Isoxazoles; PC12 Cells; Phenylurea Compounds; Rats | 2018 |
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cholinergic Agents; Depressive Disorder; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Motor Activity; Phenylurea Compounds; Prefrontal Cortex | 2018 |
Treatment duration affects cytoprotective efficacy of positive allosteric modulation of α7 nAChRs after focal ischemia in rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Drug Administration Schedule; Infarction, Middle Cerebral Artery; Isoxazoles; Male; Neuroprotective Agents; Nicotinic Agonists; Phenylurea Compounds; Rats, Sprague-Dawley | 2018 |
Perioperative activation of spinal α7 nAChR promotes recovery from preoperative stress-induced prolongation of postsurgical pain.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anxiety; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Chronic Pain; Cytokines; Hyperalgesia; Isoxazoles; Male; Microglia; Nicotinic Agonists; Phenylurea Compounds; Preoperative Period; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spine; Stress, Psychological | 2019 |
Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Astrocytes; Cognition; Cognition Disorders; Cognitive Dysfunction; Cytokines; Depression; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Phenylurea Compounds; Prefrontal Cortex | 2019 |
Allosteric Agonism of
Topics: Allosteric Regulation; Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Cell Line; Humans; Isoxazoles; Male; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Nicotinic Agonists; Phenylurea Compounds; Piperazines; Quinolines; Sulfonamides; Xenopus laevis | 2019 |
Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; HEK293 Cells; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Pyridines; Pyridinium Compounds; Quinuclidines; Thiophenes | 2019 |
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for α7 nAChRs.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Computer Simulation; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Neurotransmitter Agents; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Phenylurea Compounds; Structure-Activity Relationship; Xenopus laevis | 2019 |
Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Calcium Signaling; Cell Differentiation; Cell Line; Humans; Induced Pluripotent Stem Cells; Isoxazoles; MAP Kinase Signaling System; Nerve Net; Neurons; Phenylurea Compounds; Synaptic Transmission | 2019 |
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Galantamine; Isoxazoles; Memantine; Nootropic Agents; Phenylurea Compounds; Rats; Recognition, Psychology; Scopolamine | 2020 |
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome | 2020 |
PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea stagnalis.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Cells, Cultured; Chloride Channels; Female; Humans; Isoxazoles; Ligand-Gated Ion Channels; Lymnaea; PC12 Cells; Phenylurea Compounds; Rats; Rats, Wistar; Xenopus laevis | 2020 |
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia | 2021 |
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Humans; Isoxazoles; MCF-7 Cells; Mice; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Protein Kinase Inhibitors | 2020 |
The α7 nAChR allosteric modulator PNU-120596 amends neuroinflammatory and motor consequences of parkinsonism in rats: Role of JAK2/NF-κB/GSk3β/ TNF-α pathway.
Topics: Animals; Dopaminergic Neurons; Glycogen Synthase Kinase 3 beta; Hypokinesia; Isoxazoles; Janus Kinase 2; Neuroinflammatory Diseases; NF-kappa B; Oxidopamine; Parkinsonian Disorders; Phenylurea Compounds; Random Allocation; Rats; Tumor Necrosis Factor-alpha | 2022 |
Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Cholesterol; Humans; Isoxazoles; Ligand-Gated Ion Channels; Ligands; Lipids; Phenylurea Compounds; Receptors, Nicotinic | 2022 |
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Hippocampus; Isoxazoles; Phenylurea Compounds; Rats; Receptors, Nicotinic | 2023 |