Compounds > isoxazoles
Page last updated: 2024-08-21

isoxazoles and nms-e973

isoxazoles has been researched along with nms-e973 in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ballinari, D; Brasca, MG; Casale, E; Ciomei, M; De Ponti, A; Degrassi, A; Donati, D; Felder, E; Fogliatto, G; Galvani, A; Germani, M; Gianellini, L; Guanci, M; Isacchi, A; Mantegani, S; Paolucci, M; Pesenti, E; Polucci, P; Russo, M; Sola, F; Valsasina, B; Visco, C; Zuccotto, F1
Amboldi, N; Bindi, S; Brasca, MG; Caronni, D; Casale, E; Ceccarelli, W; Colombo, N; De Ponti, A; Donati, D; Ermoli, A; Fachin, G; Felder, ER; Ferguson, RD; Fiorelli, C; Fogliatto, G; Guanci, M; Isacchi, A; Mantegani, S; Pesenti, E; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F1
Barbagallo, I; Li Volti, G; Onni, T; Parenti, R; Pepe, F; Tibullo, D; Vanella, L; Zappalà, A1

Other Studies

3 other study(ies) available for isoxazoles and nms-e973

ArticleYear
NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jul-01, Volume: 19, Issue:13

    Topics: Animals; Antineoplastic Agents; Binding Sites; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Isoxazoles; Mice; Molecular Conformation; Molecular Docking Simulation; Neoplasm Metastasis; Organ Specificity; Protein Binding; Proteolysis; Tumor Burden; Xenograft Model Antitumor Assays

2013
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).
    Bioorganic & medicinal chemistry, 2013, Nov-15, Volume: 21, Issue:22

    Topics: Animals; Antineoplastic Agents; Binding Sites; Biomarkers, Tumor; Catalytic Domain; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Protein Binding; Structure-Activity Relationship; Transplantation, Heterologous

2013
Combined inhibition of Hsp90 and heme oxygenase-1 induces apoptosis and endoplasmic reticulum stress in melanoma.
    Acta histochemica, 2015, Volume: 117, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Heme Oxygenase-1; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Melanoma; Metalloporphyrins; Reactive Oxygen Species

2015