Compounds > isoxazoles
Page last updated: 2024-08-21

isoxazoles and mrk 016

isoxazoles has been researched along with mrk 016 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atack, JR; Carling, RW; Chambers, MS; Collinson, N; Cook, SM; Dawson, GR; Ferris, P; Hobbs, SC; Macleod, AM; Marshall, G; O'connor, D; Rycroft, W1
Atack, JR; Braun, MP; Cato, BP; Chambers, MS; Cook, SM; Hobbs, SC; Jones, P; MacLeod, AM; Maxey, R; O'Connor, D; Szekeres, HJ; Szeto, N; Wafford, KA1
Agrawal, NG; Atack, JR; Burns, HD; Chambers, MS; Dawson, GR; Eng, WS; Evans, DC; Gibson, RE; Gingrich, K; Hargreaves, RJ; Hostetler, E; Krause, S; MacLeod, AM; Maubach, KA; McKernan, RM; Murphy, MG; Musson, DG; O'Connor, D; Petty, KJ; Rodrigues, AD; Ryan, C; Sanabria, SM; Tattersall, FD; Wafford, KA1
Atack, JR1
Lecker, I; Orser, BA; Wang, DS; Yin, Y1
Boehm, GW; Chumley, MJ; Eimerbrink, MJ; Hodges, SL; Pendry, RJ; Sadler, LN; Weintraub, MK; White, JD; Wiles, JD1
Fischell, J; Kvarta, MD; LeGates, TA; Thompson, SM; Van Dyke, AM1
Boehm, GW; Chumley, MJ; Eimerbrink, MJ; Hayes, HB; Hodges, SL; Pendry, RJ; Peterman, JL; White, JD; Wiles, JD1

Reviews

1 review(s) available for isoxazoles and mrk 016

ArticleYear
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:9

    Topics: Animals; Benzodiazepines; Cognition; Diazepam; Female; Fluorobenzenes; GABA-A Receptor Agonists; Hippocampus; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Nootropic Agents; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazines; Triazoles

2011

Other Studies

7 other study(ies) available for isoxazoles and mrk 016

ArticleYear
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
    Journal of medicinal chemistry, 2004, Nov-18, Volume: 47, Issue:24

    Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cognition; Dogs; GABA-A Receptor Agonists; Isoxazoles; Maze Learning; Mice; Nootropic Agents; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA-A; Triazines

2004
Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.
    Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Hydrolysis; Isoxazoles; Macaca mulatta; Mice; Molecular Conformation; Protein Subunits; Rats; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Triazines

2006
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Convulsants; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Fibroblasts; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Hepatocytes; Hippocampus; Humans; Isoxazoles; Macaca mulatta; Male; Maze Learning; Mice; Patch-Clamp Techniques; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazines; Young Adult

2009
Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists.
    British journal of anaesthesia, 2013, Volume: 110 Suppl 1

    Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Evoked Potentials; Hippocampus; Imidazoles; Isoflurane; Isoxazoles; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Sevoflurane; Triazines

2013
Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin.
    Behavioural brain research, 2015, Jul-15, Volume: 288

    Topics: Animals; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Fear; Freezing Reaction, Cataleptic; Hippocampus; Inflammation; Insulin-Like Growth Factor I; Isoxazoles; Learning; Lipopolysaccharides; Male; Memory; Mice, Inbred C57BL; Neuroimmunomodulation; Nootropic Agents; RNA, Messenger; Time Factors; Triazines

2015
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:11

    Topics: Animals; Antidepressive Agents; CA1 Region, Hippocampal; Chronic Disease; Dietary Sucrose; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; GABA Modulators; Imidazoles; Isoxazoles; Male; Random Allocation; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Restraint, Physical; Social Behavior; Stress, Psychological; Synapses; Synaptic Transmission; Tissue Culture Techniques; Triazines

2015
The α5-GABA
    Behavioural brain research, 2019, 02-01, Volume: 359

    Topics: Amyloid beta-Peptides; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Cognition Disorders; Conditioning, Psychological; Fear; GABA Agonists; Gene Expression Regulation; Hippocampus; Isoxazoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Memory; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 4, Group A, Member 2; Peptide Fragments; Protein-Tyrosine Kinases; RNA, Messenger; Triazines

2019