isoxazoles has been researched along with mrk 016 in 8 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (37.50) | 29.6817 |
2010's | 5 (62.50) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Atack, JR; Carling, RW; Chambers, MS; Collinson, N; Cook, SM; Dawson, GR; Ferris, P; Hobbs, SC; Macleod, AM; Marshall, G; O'connor, D; Rycroft, W | 1 |
Atack, JR; Braun, MP; Cato, BP; Chambers, MS; Cook, SM; Hobbs, SC; Jones, P; MacLeod, AM; Maxey, R; O'Connor, D; Szekeres, HJ; Szeto, N; Wafford, KA | 1 |
Agrawal, NG; Atack, JR; Burns, HD; Chambers, MS; Dawson, GR; Eng, WS; Evans, DC; Gibson, RE; Gingrich, K; Hargreaves, RJ; Hostetler, E; Krause, S; MacLeod, AM; Maubach, KA; McKernan, RM; Murphy, MG; Musson, DG; O'Connor, D; Petty, KJ; Rodrigues, AD; Ryan, C; Sanabria, SM; Tattersall, FD; Wafford, KA | 1 |
Atack, JR | 1 |
Lecker, I; Orser, BA; Wang, DS; Yin, Y | 1 |
Boehm, GW; Chumley, MJ; Eimerbrink, MJ; Hodges, SL; Pendry, RJ; Sadler, LN; Weintraub, MK; White, JD; Wiles, JD | 1 |
Fischell, J; Kvarta, MD; LeGates, TA; Thompson, SM; Van Dyke, AM | 1 |
Boehm, GW; Chumley, MJ; Eimerbrink, MJ; Hayes, HB; Hodges, SL; Pendry, RJ; Peterman, JL; White, JD; Wiles, JD | 1 |
1 review(s) available for isoxazoles and mrk 016
Article | Year |
---|---|
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
Topics: Animals; Benzodiazepines; Cognition; Diazepam; Female; Fluorobenzenes; GABA-A Receptor Agonists; Hippocampus; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Nootropic Agents; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazines; Triazoles | 2011 |
7 other study(ies) available for isoxazoles and mrk 016
Article | Year |
---|---|
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cognition; Dogs; GABA-A Receptor Agonists; Isoxazoles; Maze Learning; Mice; Nootropic Agents; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA-A; Triazines | 2004 |
Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Hydrolysis; Isoxazoles; Macaca mulatta; Mice; Molecular Conformation; Protein Subunits; Rats; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Triazines | 2006 |
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
Topics: Animals; Anxiety; Behavior, Animal; Convulsants; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Fibroblasts; Flumazenil; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Hepatocytes; Hippocampus; Humans; Isoxazoles; Macaca mulatta; Male; Maze Learning; Mice; Patch-Clamp Techniques; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazines; Young Adult | 2009 |
Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Evoked Potentials; Hippocampus; Imidazoles; Isoflurane; Isoxazoles; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Sevoflurane; Triazines | 2013 |
Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin.
Topics: Animals; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Fear; Freezing Reaction, Cataleptic; Hippocampus; Inflammation; Insulin-Like Growth Factor I; Isoxazoles; Learning; Lipopolysaccharides; Male; Memory; Mice, Inbred C57BL; Neuroimmunomodulation; Nootropic Agents; RNA, Messenger; Time Factors; Triazines | 2015 |
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
Topics: Animals; Antidepressive Agents; CA1 Region, Hippocampal; Chronic Disease; Dietary Sucrose; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; GABA Modulators; Imidazoles; Isoxazoles; Male; Random Allocation; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Restraint, Physical; Social Behavior; Stress, Psychological; Synapses; Synaptic Transmission; Tissue Culture Techniques; Triazines | 2015 |
The α5-GABA
Topics: Amyloid beta-Peptides; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Cognition Disorders; Conditioning, Psychological; Fear; GABA Agonists; Gene Expression Regulation; Hippocampus; Isoxazoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Memory; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 4, Group A, Member 2; Peptide Fragments; Protein-Tyrosine Kinases; RNA, Messenger; Triazines | 2019 |