isoxazoles has been researched along with mna 715 in 87 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 36 (41.38) | 18.2507 |
2000's | 47 (54.02) | 29.6817 |
2010's | 4 (4.60) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lin, Y; Segers, C; Waer, M | 1 |
Kurrle, R; Schorlemmer, HU | 6 |
Bartlett, RR; Brendel, S; Schorlemmer, HU | 1 |
Bartlett, RR; Kurrle, R; Schorlemmer, HU | 4 |
Kurrle, R; Ruuth, E; Schorlemmer, HU; Schwab, W | 1 |
Bartlett, R; Kurrle, R; Lauffer, L; Ruuth, E; Schorlemmer, HU | 1 |
Bartlett, RR; Schorlemmer, HU | 4 |
Kurrle, R; Ruuth, E; Schorlemmer, HU | 3 |
Gregory, CR; Morris, RE; Patz, JD; Silva, HT | 1 |
Lindner, JK; Zantl, N | 1 |
Ekberg, H; Qi, Z; Simanaitis, M | 2 |
Ekberg, H; Qi, Z | 2 |
Bartlett, RR; Kurrle, R; Lindner, JK; Schorlemmer, HU | 1 |
Bartlett, RR; Schleyerbach, R; Schorlemmer, HU | 1 |
Czech, J; Schorlemmer, HU; Schwab, W | 1 |
Chambron, N; Emmanuilidis, K; Gerauer, K; Heidecke, CD; Maier, S; Pfeffer, K; Zantl, N | 1 |
Morris, RE; Sherwood, SW; Silva, HT; Slauson, SD | 1 |
Billingham, ME; Morris, RE; Silva, HT; Slauson, S; Wang, Y | 1 |
Bartlett, RR; Kurrle, R; Schleyerbach, R; Schorlemmer, HU | 2 |
Czech, J; Kurrle, R; Schorlemmer, HU | 1 |
Bari, S; Groth, CG; Korsgren, O; Song, Z; Sundberg, B; Wennberg, L; Wijkström, M; Zhang, J | 1 |
Bouillon, R; Gysemans, C; Laureys, J; Mathieu, C; Waer, M | 1 |
duToit, DF; Lyners, R; Mattysen, J; Muller, CJ; Muller, N; Page, BJ | 1 |
Schorlemmer, HU | 1 |
Fujita, M; Furukawa, H; Jin, MB; Mino, K; Nakayama, M; Ogata, T; Shimamura, T; Suzuki, T; Taniguchi, M; Todo, S | 1 |
Bîrsan, T; Dambrin, C; Fitzsimmons, WE; Klupp, J; Larson, MJ; Morris, RE; Stalder, M | 1 |
Benediktsson, H; Crews, G; Ebbs, A; Erickson, L; Fisniku, O; Jang, MS; Jiang, AH; Kobayashi, M; Pan, F; Paul, LC; Wynn, C | 1 |
Bekersky, I; Bilolo, K; Chen, H; Daloze, P; Fitzsimmons, WE; Jiang, W; Johnson, S; Ma, A; Ouyang, J; Qi, S; Vu, MD; Wang, X; Xu, D; Zhu, S | 1 |
Bernsteen, L; Gregory, CR; Griffey, SM; Kyles, AE; Lilja, HS; Morris, RE; Pierce, J | 1 |
Bekersky, I; Chen, H; Fitzsimmons, WE; Jiang, W; Ma, A; Qi, S; Vu, MD; Wang, X; Wu, J; Xu, D | 1 |
Bekersky, I; Bilolo, KK; Chen, H; Fitzsimmons, WE; Hebert, MJ; Jiang, W; Ouyang, J; Qi, S; Wang, X; Xu, D; Zhu, S | 1 |
Häyry, P; Savikko, J; Von Willebrand, E | 1 |
Deuse, T; Reichenspurner, H; Schrepfer, S | 2 |
First, MR; Fitzsimmons, WE | 2 |
Fawcett, J; Johnson, DW | 1 |
Chang, R; Charpentier, B; Grinyó, JM; Jurewicz, A; Klinger, M; Kreis, H; Mourad, G; Neuhaus, P; Paczek, L; Paul, LC; Rostaing, L; Short, C; Squifflet, JP; van Hooff, JP; Vanrenterghem, Y; Wlodarczyk, Z | 1 |
Böger, RH; Deuse, T; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S; Schwedhelm, E | 1 |
Hirohashi, K; Ikeda, K; Kubo, S; Minamiyama, Y; Okuda, T; Suehiro, S; Takemura, S; Tanaka, H; Yamamoto, S; Yamasaki, K | 1 |
Andreoni, KA; Evers, DL; Huang, ES; Huong, SM; Wang, X | 1 |
Deuse, T; Reichenspurner, H; Schäfer, H; Schrepfer, S | 1 |
Chong, AS; Knight, DA; Ma, L; Meister, GT; Shen, J; Waldman, WJ; Williams, JW; Yin, DP; Zeng, H | 1 |
Kaplan, MJ | 1 |
Hörl, WH; Kirsch, B; Säemann, MD; Stuhlmeier, KM; Stulnig, TM; Watschinger, B; Zeyda, M | 1 |
Geyeregger, R; Hörl, WH; Poglitsch, M; Säemann, MD; Stulnig, TM; Watschinger, B; Zeyda, M | 1 |
Bolte, H; Brossmann, J; Fändrich, F; Hedderich, J; Heller, M; Jahnke, T; Müller-Hülsbeck, S; Rector, L; Schäfer, FK; Schäfer, PJ | 1 |
Akhtar, S; Chen, YL; Kobayashi, M; Murai, H | 1 |
Geyeregger, R; Hörl, WH; Kirsch, BM; Säemann, MD; Stuhlmeier, KM; Stulnig, TM; Zeyda, M; Zlabinger, GJ | 1 |
Böger, R; Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S; Schwedhelm, E | 1 |
Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S | 1 |
Detter, C; Deuse, T; Koch-Nolte, F; Reichenspurner, H; Schrepfer, S | 1 |
Hilbrands, LB; Joosten, I; Koenen, HJ; Kreijveld, E; van Hooff, HJ | 1 |
Böger, R; Deuse, T; Haddad, M; Münzel, T; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schäfer, H; Schrepfer, S; Sultan, KR | 1 |
Geyeregger, R; Hörl, WH; Koyasu, S; Poglitsch, M; Saemann, MD; Stulnig, TM; Watschinger, B; Weichhart, T; Zeyda, M; Zlabinger, GJ | 1 |
Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E | 3 |
Deuse, T; Haddad, M; Koch-Nolte, F; Krieger, T; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schäfer, H; Schrepfer, S | 1 |
Deuse, T; Fischbein, MP; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schrepfer, S | 1 |
Birnbaum, F; Reinhard, T; Reis, A; Scholz, C; Schwartzkopff, J | 1 |
Deng, M; Heemann, U; Huang, H; Lutz, J; Roos, M; Schmaderer, C; Strobl, M; Wagner, B | 1 |
Deuse, T; Hoyt, G; Koyanagi, T; Robbins, RC; Schrepfer, S | 1 |
Hoppe-Seyler, F; Hoppe-Seyler, K; Lohrey, C; Sauer, P; Weigand, K | 1 |
Hou, J; Li, J; Tang, DN; Wei, JM; Xu, Y; Yu, ZY | 1 |
Bruggeman, CA; de Graaf, R; Grauls, G; Kloppenburg, G; Stassen, F; van Hooff, JP | 1 |
Agüeros, C; Arias, M; Benito, A; Cosme, LS; Gimenez, T; Gómez-Alamillo, C; Merino, J; Merino, R; Ramos-Barrón, MA; Santiuste, I | 1 |
Bloudícková, S; Honsová, E; Lodererová, A; Rajnoch, J; Viklický, O | 1 |
First, MR; Fitzsimmons, W; Guasch, A; Holman, J; Roy-Chaudhury, P; Woodle, ES | 1 |
Hoppe-Seyler, F; Hoppe-Seyler, K; Lohrey, C; Sauer, P | 1 |
Krämer, BK; Ostrowski, M; Squifflet, JP; Vanrenterghem, Y; Wlodarczyk, Z | 1 |
5 review(s) available for isoxazoles and mna 715
Article | Year |
---|---|
Development of a novel drug for transplantation: current results and future perspectives.
Topics: Alkynes; Aniline Compounds; Animals; Autoimmune Diseases; Biological Availability; Crotonates; Drug Design; Graft Rejection; Graft Survival; Graft vs Host Disease; Graft vs Host Reaction; Heart Transplantation; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Nitriles; Skin Transplantation; Toluidines; Transplantation, Homologous | 2001 |
New drugs to improve transplant outcomes.
Topics: Alkynes; Animals; Delayed-Action Preparations; Diterpenes; Epoxy Compounds; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Nitriles; Phenanthrenes; Probucol; Tacrolimus | 2004 |
FK778: a powerful immunosuppressive, but will it really be good for you?
Topics: Alkynes; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles | 2004 |
FK778, a synthetic malononitrilamide.
Topics: Alkynes; Animals; Clinical Trials, Phase I as Topic; Humans; Immunosuppressive Agents; Isoxazoles; Nitriles; Organ Transplantation; Randomized Controlled Trials as Topic; Treatment Outcome | 2004 |
FK-778 Astellas.
Topics: Alkynes; Animals; Clinical Trials, Phase II as Topic; Drug Industry; Graft Rejection; Humans; Isoxazoles; Nitriles; Organ Transplantation | 2005 |
3 trial(s) available for isoxazoles and mna 715
Article | Year |
---|---|
The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Alkynes; Drug Therapy, Combination; Female; Glucocorticoids; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Male; Middle Aged; Nitriles; Patient Compliance; Prednisolone; Tacrolimus; Treatment Outcome | 2004 |
Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy.
Topics: Algorithms; Alkynes; Creatinine; Cyclosporine; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Mycophenolic Acid; Nitriles; Patient Compliance; Polyomavirus Infections; Sirolimus; Tacrolimus; Time Factors; Viral Load | 2010 |
A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation.
Topics: Adult; Alkynes; Double-Blind Method; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Nitriles; Steroids; Tacrolimus | 2012 |
79 other study(ies) available for isoxazoles and mna 715
Article | Year |
---|---|
Efficacy of the malononitrilamide X 920715 as compared with leflunomide in cardiac allo- and xenotransplantation in rats.
Topics: Alkynes; Animals; Cricetinae; Drug Synergism; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Nitriles; Rats; Rats, Inbred Strains; Transplantation, Heterologous; Transplantation, Homologous | 1996 |
Control of mouse-to-rat skin xenograft rejection by malononitrilamides.
Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous | 1996 |
Malononitrilamides prevent the development of murine systemic lupus erythematosus-like diseases in BDF1 hybrid mice and MRL/lpr autoimmune mice.
Topics: Aging; Alkynes; Animals; Antibody Formation; Crosses, Genetic; Disease Models, Animal; Female; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles | 1996 |
Malononitrilamides inhibit the development of various murine graft-vs-host diseases.
Topics: Alkynes; Animals; Graft vs Host Disease; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymphocyte Transfusion; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Nitriles; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Spleen; Splenomegaly; Time Factors; Transplantation, Homologous | 1996 |
Acute skin graft rejection can be prevented and treated in rat models by malononitrilamides.
Topics: Acute Disease; Alkynes; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Time Factors | 1996 |
Malononitrilamides inhibit T- and B-cell responsiveness.
Topics: Alkynes; Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; Humans; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Interleukin-4; Isoxazoles; Lymphocyte Activation; Mice; Nitriles; Rats; Spleen; T-Lymphocytes | 1996 |
Malononitrilamides (MNA 279 and MNA 715) have therapeutic activity in acute and chronic relapsing experimental allergic encephalomyelitis (EAE).
Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Isoxazoles; Kinetics; Nitriles; Rats; Rats, Inbred Lew; Recurrence | 1997 |
Various graft vs. host diseases (GvHD) in rodents can be prevented and treated by malononitrilamides (MNAs).
Topics: Alkynes; Animals; Graft vs Host Disease; Immunosuppressive Agents; Isoxazoles; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1997 |
Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715.
Topics: Aging; Alkynes; Animals; Autoimmune Diseases; Female; Immunosuppressive Agents; Isoxazoles; Kinetics; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred DBA; Nitriles; Spleen; Splenomegaly | 1997 |
Long-term xenograft survival by combination therapy of malononitrilamide MNA 715 with cyclosporine.
Topics: Alkynes; Animals; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous | 1997 |
Synergistic activity of malononitrilamides with cyclosporine to control and reverse xenograft rejection.
Topics: Alkynes; Animals; Antibody Formation; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Transplantation, Heterologous | 1997 |
The alloreactivity in the popliteal lymph node (PLN) assay is regulated by malononitrilamides (MNAs).
Topics: Alkynes; Animals; Cell Division; Graft vs Host Reaction; Hybridization, Genetic; Immunosuppressive Agents; Isoantigens; Isoxazoles; Knee; Lymph Nodes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1997 |
The new immunosuppressants, the malononitrilamides MNA 279 and MNA 715, inhibit various graft-vs.-host diseases (GvHD) in rodents.
Topics: Alkynes; Animals; Disease Models, Animal; Graft vs Host Disease; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1997 |
Therapeutic activity of malononitrilamides (MNA 279 and MNA 715) on acute and chronic, relapsing, experimental, allergic encephalomyelitis (EAE).
Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred Strains; Nitriles; Rabbits; Rats; Rats, Inbred Lew | 1997 |
Hyperacute skin allograft rejection in presensitized rats is abrogated by malononitrilamides.
Topics: Acute Disease; Alkynes; Animals; Graft Rejection; Immunization; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoantigens; Isoxazoles; Leflunomide; Lymphocyte Transfusion; Nitriles; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Structure-Activity Relationship; Time Factors; Transplantation, Homologous | 1998 |
Inhibition of alloreactivity in the popliteal lymph node assay by malononitrilamides.
Topics: Alkynes; Animals; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lymph Nodes; Lymphocyte Activation; Lymphocyte Transfusion; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Homologous | 1998 |
Malononitrilamides reduce IgM and IgG xenoantibodies and prolong skin xenograft survival in a mouse-to rat model.
Topics: Acute Disease; Alkynes; Animals; Antibodies, Heterophile; Antibody Formation; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous | 1998 |
Comparative effects of malononitriloamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats.
Topics: Adult; Alkynes; Animals; B-Lymphocytes; Cats; Dogs; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Macaca mulatta; Male; Nitriles; Rats; Rats, Inbred Lew; Species Specificity; T-Lymphocytes | 1998 |
Synergism of the malononitrilamides 279 and 715 with cyclosporine A in the induction of long-term cardiac allograft survival.
Topics: Alkynes; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Species Specificity; Time Factors | 1998 |
Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine.
Topics: Acute Disease; Alkynes; Animals; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Skin Transplantation | 1998 |
Regulation of alloreactivity in the popliteal lymph node assay by the new immunosuppressants: malononitrilamides.
Topics: Alkynes; Animals; Graft vs Host Disease; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Lymph Nodes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1998 |
Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats.
Topics: Alkynes; Animals; Antibody Specificity; Autoantibodies; Cyclosporine; Drug Synergism; Graft Rejection; Heart Transplantation; Immunization; Immunosuppressive Agents; Isoxazoles; Male; Myocardium; Nitriles; Rats; Rats, Inbred Strains | 1998 |
Malononitrilamides 715 and 279 prolong rat cardiac allograft survival, reverse ongoing rejection, inhibit allospecific antibody production and interact positively with cyclosporin.
Topics: Alkynes; Aniline Compounds; Animals; Antibody Formation; Crotonates; Cyclosporine; Drug Interactions; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Hydroxybutyrates; Immunoglobulin Allotypes; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Toluidines; Transplantation, Homologous | 1998 |
Malononitrilamides prevent and suppress allospecific antibody production.
Topics: Alkynes; Animals; Antibody Formation; Heart Transplantation; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Transplantation, Homologous | 1998 |
Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus.
Topics: Acrylamide; Acrylamides; Alkynes; Animals; Caproates; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Tacrolimus; Transplantation, Homologous | 1998 |
Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis.
Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibodies, Antinuclear; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Disease Models, Animal; Female; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Mutant Strains; Nitriles; Rats; Rats, Inbred Lew | 1998 |
Modulation of immunoglobulin dysregulation in graft versus host-and systemic lupus erythematosus-like diseases by malononitrilamides.
Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibody Formation; Autoantibodies; Autoimmune Diseases; Caproates; Crosses, Genetic; Female; Glomerulonephritis; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymphocyte Transfusion; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles; Spleen; Transplantation, Homologous | 1998 |
Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival.
Topics: Acrylamide; Acrylamides; Administration, Oral; Alkynes; Animals; Caproates; Drug Synergism; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Tacrolimus; Time Factors; Transplantation, Heterologous | 1998 |
Inhibition of PDGF-stimulated rat smooth muscle cell proliferation by MNA 279 and MNA 715.
Topics: Alkynes; Animals; Aorta, Thoracic; Cell Division; Cell Line; Dihydroorotate Dehydrogenase; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Platelet-Derived Growth Factor; Rats; Uridine | 1998 |
Long-term cardiac allograft survival in mice treated with malononitrilamide 715.
Topics: Alkynes; Animals; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitriles; Tacrolimus; Time Factors; Transplantation, Homologous; Transplantation, Isogeneic | 1998 |
Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay.
Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Biphenyl Compounds; Caproates; Crotonates; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Male; Nitriles; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Receptors, OX40; Receptors, Tumor Necrosis Factor; Toluidines; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1999 |
Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts.
Topics: Alkynes; Animals; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Tacrolimus; Time Factors; Transplantation, Homologous | 1999 |
Quilty effect in heterotopic cardiac allografts in malononitrilamide-treated rats.
Topics: Acrylamides; Alkynes; Animals; Caproates; Endocardium; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Myocardium; Nitriles; Rats; Transplantation, Heterotopic; Transplantation, Homologous | 1999 |
Disease-modifying activity of malononitrilamides, derivatives of leflunomide's active metabolite, on models of rheumatoid arthritis.
Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Crotonates; Dose-Response Relationship, Drug; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Lew; Toluidines | 1999 |
Generation of O2- radicals in macrophages can be inhibited in vitro and in vivo by derivatives of leflunomide's primary metabolite.
Topics: Acrylamides; Alkynes; Animals; Caproates; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Free Radicals; Humans; Immunosuppressive Agents; Isoxazoles; Macrophages; Mice; Mice, Inbred NOD; Nitriles; Superoxides | 1999 |
The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine.
Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Caproates; Cell Division; Crotonates; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Platelet-Derived Growth Factor; Rats; Toluidines; Uridine | 1999 |
Efficacy of malononitriloamide 279 and 715 in islet xenotransplantation: a study in the pig-to-rat model.
Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Mycophenolic Acid; Nitriles; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2000 |
Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice.
Topics: Alkynes; Animals; Cyclosporine; Diabetes Mellitus, Type 1; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred NOD; Nitriles; Rats; Transplantation, Heterologous | 2001 |
Efficacy of malononitrilamide 715 as immunosuppressant, alone or in combination with cyclosporin, in allogeneic foetal rat pancreatic transplantation.
Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Pancreas Transplantation; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Subrenal Capsule Assay; T-Lymphocytes; Transplantation, Homologous; Weight Gain; Weight Loss | 2001 |
A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs.
Topics: Alkynes; Animals; Cyclosporine; Dogs; Female; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Tacrolimus | 2002 |
In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates.
Topics: Alkynes; Animals; Cell Division; Flow Cytometry; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Macaca fascicularis; Nitriles; T-Lymphocytes | 2003 |
FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts.
Topics: Alkynes; Animals; Antibody Formation; Gene Expression; Graft Rejection; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Kidney; Kidney Transplantation; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transforming Growth Factor beta; Transplantation, Homologous | 2003 |
Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates.
Topics: Alanine Transaminase; Alkynes; Animals; Aspartate Aminotransferases; Body Weight; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Liver; Male; Nitriles; Tacrolimus; Time Factors | 2003 |
Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs.
Topics: Alkynes; Animals; Cyclosporine; Dogs; Drug Therapy, Combination; Emulsions; Graft Survival; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Nitriles; Osmolar Concentration | 2003 |
Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts.
Topics: Alkynes; Animals; B-Lymphocytes; Cell Division; Drug Therapy, Combination; Female; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Lymphocyte Activation; Mice; Nitriles; Rats; Rats, Inbred Lew; Species Specificity; T-Lymphocytes; Tacrolimus; Transplantation, Homologous | 2003 |
Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat.
Topics: Acute Disease; Alkynes; Animals; Drug Synergism; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Myocardium; Nitriles; Rats; Rats, Inbred ACI; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Homologous | 2003 |
Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection.
Topics: Alkynes; Angiogenesis Inhibitors; Animals; Benzamides; Blood Vessels; Constriction, Pathologic; Dihydroorotate Dehydrogenase; Graft Rejection; Imatinib Mesylate; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Wistar; Recurrence; Tunica Intima; Uridine; Vascular Diseases | 2003 |
Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
Topics: Alkynes; Animals; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Models, Animal; Mycophenolic Acid; Nitriles; Rats; Transplantation, Homologous | 2003 |
The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
Topics: Alkynes; Animals; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Tacrolimus | 2004 |
FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
Topics: Acute Disease; Alkynes; Animals; Antineoplastic Agents; Cell Adhesion; Endothelial Cells; Graft Rejection; Heart Transplantation; In Vitro Techniques; Intercellular Adhesion Molecule-1; Iodine Radioisotopes; Isoxazoles; Lymphocytes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2004 |
FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.
Topics: Acute Disease; Alkynes; Animals; Drug Therapy, Combination; Graft Rejection; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Liver; Liver Transplantation; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Homologous | 2004 |
Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778.
Topics: Alkynes; Antiviral Agents; Cell Line; Cytomegalovirus; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Signal Transduction; Viral Plaque Assay; Viral Proteins; Virus Replication | 2005 |
FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
Topics: Acute Disease; Alkynes; Animals; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Isoxazoles; Male; Nitriles; P-Selectin; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Homologous; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2005 |
Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats.
Topics: Alkynes; Animals; Antiviral Agents; Body Weight; Cytomegalovirus Infections; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Transplantation, Homologous; Uridine; Virus Replication | 2005 |
The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells.
Topics: Alkynes; Binding Sites; Dendritic Cells; Humans; Immunosuppressive Agents; Isoxazoles; Kinetics; Lipopolysaccharides; NF-kappa B; Nitriles; Oligodeoxyribonucleotides | 2005 |
The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse.
Topics: Alkynes; Cell Communication; Humans; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Nitriles; T-Lymphocytes | 2005 |
2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis.
Topics: Actins; Administration, Oral; Alkynes; Angioplasty, Balloon; Animals; Disease Models, Animal; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Isoxazoles; Male; Muscle, Smooth, Vascular; Nitriles; Rats; Rats, Inbred Lew; Tunica Intima | 2005 |
In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry.
Topics: Alkynes; Chromatography, Liquid; Humans; Hydrogen-Ion Concentration; Hydroxylation; Isoxazoles; Mass Spectrometry; Molecular Structure; Nitriles; Optical Rotation; Stereoisomerism | 2005 |
Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778.
Topics: Alkynes; Antigens, CD; Cell Differentiation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Humans; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; NF-kappa B; Nitriles; T-Lymphocytes; Uridine | 2005 |
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
Topics: Actins; Alkynes; Animals; Bronchiolitis Obliterans; Disease Models, Animal; Granulation Tissue; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Nitriles; Postoperative Complications; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Trachea | 2005 |
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
Topics: Alkynes; Animals; Disease Models, Animal; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Lung Diseases, Obstructive; Lung Transplantation; Male; Myocytes, Smooth Muscle; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Homologous; Transplantation, Isogeneic | 2006 |
FK778: new cellular and molecular mechanisms of action.
Topics: Alkynes; Animals; CD28 Antigens; Cell Adhesion; Endothelium, Vascular; Flow Cytometry; Isoxazoles; Lymphocyte Activation; Lymphocytes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Antigen, T-Cell; Tumor Necrosis Factor-alpha; Uridine | 2006 |
The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells.
Topics: Adult; Alkynes; Antigens, CD; Antigens, Differentiation; CD4-Positive T-Lymphocytes; Cell Communication; Cell Division; Cells, Cultured; CTLA-4 Antigen; Cyclin-Dependent Kinase Inhibitor p27; Drug Evaluation, Preclinical; Forkhead Transcription Factors; Glucocorticoid-Induced TNFR-Related Protein; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Intracellular Signaling Peptides and Proteins; Isoantigens; Isoxazoles; L-Selectin; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Nitriles; Phosphorylation; Protein Processing, Post-Translational; Pyrimidines; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; Uridine | 2007 |
Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
Topics: Alkynes; Animals; Aorta, Abdominal; Carrier Proteins; Cell Movement; Cell Proliferation; Endothelium, Vascular; Graft Occlusion, Vascular; Hyperplasia; Immunosuppressive Agents; Isoxazoles; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Rats; Rats, Inbred Lew; RNA, Messenger; Sirolimus; Smad7 Protein; Tacrolimus; Transforming Growth Factor beta1; Tunica Intima; Vasodilation; Vasodilator Agents | 2007 |
Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation.
Topics: Alkynes; Antigen-Presenting Cells; Antimetabolites; Calcineurin; Cells, Cultured; Humans; Immunosuppressive Agents; Isoxazoles; Models, Immunological; NF-kappa B; Nitriles; T-Lymphocytes | 2007 |
The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta.
Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous | 2006 |
The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression.
Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Rats; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous; Transplantation, Isogeneic | 2006 |
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
Topics: Alkynes; Animals; Antibodies, Anti-Idiotypic; Aorta, Abdominal; Cricetinae; Disease Models, Animal; Endothelium, Vascular; Flow Cytometry; Graft Rejection; Humans; Immunoglobulin G; Immunoglobulin M; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Heterologous; Treatment Outcome | 2007 |
Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tacrolimus; Trachea; Transplantation, Homologous | 2007 |
The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model.
Topics: Alkynes; Animals; Cornea; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Mycophenolic Acid; Nitriles; Postoperative Care; Postoperative Period; Rats; Rats, Inbred F344; Rats, Inbred Lew; Survival Analysis; Treatment Outcome | 2007 |
The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.
Topics: Alkynes; Animals; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Nitriles; Proteinuria; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Transforming Growth Factor beta; Transplantation, Homologous | 2007 |
Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
Topics: Alkynes; Animals; Aorta; Aortic Diseases; Chronic Disease; Cyclosporine; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred ACI; Transplantation, Homologous | 2008 |
FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.
Topics: Alkynes; Animals; Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Male; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred WF; Risk Factors; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous | 2008 |
Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein.
Topics: Alkynes; Antiviral Agents; DNA-Binding Proteins; G1 Phase; HeLa Cells; Human papillomavirus 16; Human papillomavirus 18; Humans; Isoxazoles; Nitriles; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Phosphorylation; Retinoblastoma Protein; S Phase; Tumor Suppressor Protein p53 | 2009 |
The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells.
Topics: Adjuvants, Immunologic; Alkynes; Antigens, CD; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells; Flow Cytometry; Humans; Isoxazoles; Leflunomide; Nitriles; Phenotype; Reference Values; Sirolimus | 2009 |
FK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model.
Topics: Alkynes; Animals; Anti-Inflammatory Agents; Antiviral Agents; Herpesviridae Infections; Hyperplasia; Immunosuppressive Agents; Isoxazoles; Male; Muromegalovirus; Nitriles; Rats; Transplants; Tunica Intima | 2009 |
Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction.
Topics: Age Factors; Aging; Alkynes; Animals; Antibody Formation; Autoantibodies; B-Lymphocytes; Dose-Response Relationship, Drug; Genes, bcl-2; Humans; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; T-Lymphocytes; Transplantation Tolerance | 2009 |
Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
Topics: Alkynes; Animals; Blood Pressure; Disease Models, Animal; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Diseases; Leflunomide; Male; Nitriles; Placebos; Rats; Rats, Transgenic; Reperfusion Injury | 2010 |
The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro.
Topics: Alkynes; Cells, Cultured; Enzyme Inhibitors; HEK293 Cells; Hep G2 Cells; Hepatitis B virus; Humans; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Leflunomide; Mycophenolic Acid; Nitriles; Real-Time Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Virus Replication | 2012 |