Compounds > isoxazoles
Page last updated: 2024-08-21

isoxazoles and mna 715

isoxazoles has been researched along with mna 715 in 87 studies

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's36 (41.38)18.2507
2000's47 (54.02)29.6817
2010's4 (4.60)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, Y; Segers, C; Waer, M1
Kurrle, R; Schorlemmer, HU6
Bartlett, RR; Brendel, S; Schorlemmer, HU1
Bartlett, RR; Kurrle, R; Schorlemmer, HU4
Kurrle, R; Ruuth, E; Schorlemmer, HU; Schwab, W1
Bartlett, R; Kurrle, R; Lauffer, L; Ruuth, E; Schorlemmer, HU1
Bartlett, RR; Schorlemmer, HU4
Kurrle, R; Ruuth, E; Schorlemmer, HU3
Gregory, CR; Morris, RE; Patz, JD; Silva, HT1
Lindner, JK; Zantl, N1
Ekberg, H; Qi, Z; Simanaitis, M2
Ekberg, H; Qi, Z2
Bartlett, RR; Kurrle, R; Lindner, JK; Schorlemmer, HU1
Bartlett, RR; Schleyerbach, R; Schorlemmer, HU1
Czech, J; Schorlemmer, HU; Schwab, W1
Chambron, N; Emmanuilidis, K; Gerauer, K; Heidecke, CD; Maier, S; Pfeffer, K; Zantl, N1
Morris, RE; Sherwood, SW; Silva, HT; Slauson, SD1
Billingham, ME; Morris, RE; Silva, HT; Slauson, S; Wang, Y1
Bartlett, RR; Kurrle, R; Schleyerbach, R; Schorlemmer, HU2
Czech, J; Kurrle, R; Schorlemmer, HU1
Bari, S; Groth, CG; Korsgren, O; Song, Z; Sundberg, B; Wennberg, L; Wijkström, M; Zhang, J1
Bouillon, R; Gysemans, C; Laureys, J; Mathieu, C; Waer, M1
duToit, DF; Lyners, R; Mattysen, J; Muller, CJ; Muller, N; Page, BJ1
Schorlemmer, HU1
Fujita, M; Furukawa, H; Jin, MB; Mino, K; Nakayama, M; Ogata, T; Shimamura, T; Suzuki, T; Taniguchi, M; Todo, S1
Bîrsan, T; Dambrin, C; Fitzsimmons, WE; Klupp, J; Larson, MJ; Morris, RE; Stalder, M1
Benediktsson, H; Crews, G; Ebbs, A; Erickson, L; Fisniku, O; Jang, MS; Jiang, AH; Kobayashi, M; Pan, F; Paul, LC; Wynn, C1
Bekersky, I; Bilolo, K; Chen, H; Daloze, P; Fitzsimmons, WE; Jiang, W; Johnson, S; Ma, A; Ouyang, J; Qi, S; Vu, MD; Wang, X; Xu, D; Zhu, S1
Bernsteen, L; Gregory, CR; Griffey, SM; Kyles, AE; Lilja, HS; Morris, RE; Pierce, J1
Bekersky, I; Chen, H; Fitzsimmons, WE; Jiang, W; Ma, A; Qi, S; Vu, MD; Wang, X; Wu, J; Xu, D1
Bekersky, I; Bilolo, KK; Chen, H; Fitzsimmons, WE; Hebert, MJ; Jiang, W; Ouyang, J; Qi, S; Wang, X; Xu, D; Zhu, S1
Häyry, P; Savikko, J; Von Willebrand, E1
Deuse, T; Reichenspurner, H; Schrepfer, S2
First, MR; Fitzsimmons, WE2
Fawcett, J; Johnson, DW1
Chang, R; Charpentier, B; Grinyó, JM; Jurewicz, A; Klinger, M; Kreis, H; Mourad, G; Neuhaus, P; Paczek, L; Paul, LC; Rostaing, L; Short, C; Squifflet, JP; van Hooff, JP; Vanrenterghem, Y; Wlodarczyk, Z1
Böger, RH; Deuse, T; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S; Schwedhelm, E1
Hirohashi, K; Ikeda, K; Kubo, S; Minamiyama, Y; Okuda, T; Suehiro, S; Takemura, S; Tanaka, H; Yamamoto, S; Yamasaki, K1
Andreoni, KA; Evers, DL; Huang, ES; Huong, SM; Wang, X1
Deuse, T; Reichenspurner, H; Schäfer, H; Schrepfer, S1
Chong, AS; Knight, DA; Ma, L; Meister, GT; Shen, J; Waldman, WJ; Williams, JW; Yin, DP; Zeng, H1
Kaplan, MJ1
Hörl, WH; Kirsch, B; Säemann, MD; Stuhlmeier, KM; Stulnig, TM; Watschinger, B; Zeyda, M1
Geyeregger, R; Hörl, WH; Poglitsch, M; Säemann, MD; Stulnig, TM; Watschinger, B; Zeyda, M1
Bolte, H; Brossmann, J; Fändrich, F; Hedderich, J; Heller, M; Jahnke, T; Müller-Hülsbeck, S; Rector, L; Schäfer, FK; Schäfer, PJ1
Akhtar, S; Chen, YL; Kobayashi, M; Murai, H1
Geyeregger, R; Hörl, WH; Kirsch, BM; Säemann, MD; Stuhlmeier, KM; Stulnig, TM; Zeyda, M; Zlabinger, GJ1
Böger, R; Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S; Schwedhelm, E1
Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S1
Detter, C; Deuse, T; Koch-Nolte, F; Reichenspurner, H; Schrepfer, S1
Hilbrands, LB; Joosten, I; Koenen, HJ; Kreijveld, E; van Hooff, HJ1
Böger, R; Deuse, T; Haddad, M; Münzel, T; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schäfer, H; Schrepfer, S; Sultan, KR1
Geyeregger, R; Hörl, WH; Koyasu, S; Poglitsch, M; Saemann, MD; Stulnig, TM; Watschinger, B; Weichhart, T; Zeyda, M; Zlabinger, GJ1
Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E3
Deuse, T; Haddad, M; Koch-Nolte, F; Krieger, T; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schäfer, H; Schrepfer, S1
Deuse, T; Fischbein, MP; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schrepfer, S1
Birnbaum, F; Reinhard, T; Reis, A; Scholz, C; Schwartzkopff, J1
Deng, M; Heemann, U; Huang, H; Lutz, J; Roos, M; Schmaderer, C; Strobl, M; Wagner, B1
Deuse, T; Hoyt, G; Koyanagi, T; Robbins, RC; Schrepfer, S1
Hoppe-Seyler, F; Hoppe-Seyler, K; Lohrey, C; Sauer, P; Weigand, K1
Hou, J; Li, J; Tang, DN; Wei, JM; Xu, Y; Yu, ZY1
Bruggeman, CA; de Graaf, R; Grauls, G; Kloppenburg, G; Stassen, F; van Hooff, JP1
Agüeros, C; Arias, M; Benito, A; Cosme, LS; Gimenez, T; Gómez-Alamillo, C; Merino, J; Merino, R; Ramos-Barrón, MA; Santiuste, I1
Bloudícková, S; Honsová, E; Lodererová, A; Rajnoch, J; Viklický, O1
First, MR; Fitzsimmons, W; Guasch, A; Holman, J; Roy-Chaudhury, P; Woodle, ES1
Hoppe-Seyler, F; Hoppe-Seyler, K; Lohrey, C; Sauer, P1
Krämer, BK; Ostrowski, M; Squifflet, JP; Vanrenterghem, Y; Wlodarczyk, Z1

Reviews

5 review(s) available for isoxazoles and mna 715

ArticleYear
Development of a novel drug for transplantation: current results and future perspectives.
    Transplantation proceedings, 2001, Volume: 33, Issue:3

    Topics: Alkynes; Aniline Compounds; Animals; Autoimmune Diseases; Biological Availability; Crotonates; Drug Design; Graft Rejection; Graft Survival; Graft vs Host Disease; Graft vs Host Reaction; Heart Transplantation; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Nitriles; Skin Transplantation; Toluidines; Transplantation, Homologous

2001
New drugs to improve transplant outcomes.
    Transplantation, 2004, May-15, Volume: 77, Issue:9 Suppl

    Topics: Alkynes; Animals; Delayed-Action Preparations; Diterpenes; Epoxy Compounds; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Nitriles; Phenanthrenes; Probucol; Tacrolimus

2004
FK778: a powerful immunosuppressive, but will it really be good for you?
    Transplantation, 2004, Jul-15, Volume: 78, Issue:1

    Topics: Alkynes; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles

2004
FK778, a synthetic malononitrilamide.
    Yonsei medical journal, 2004, Dec-31, Volume: 45, Issue:6

    Topics: Alkynes; Animals; Clinical Trials, Phase I as Topic; Humans; Immunosuppressive Agents; Isoxazoles; Nitriles; Organ Transplantation; Randomized Controlled Trials as Topic; Treatment Outcome

2004
FK-778 Astellas.
    Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:5

    Topics: Alkynes; Animals; Clinical Trials, Phase II as Topic; Drug Industry; Graft Rejection; Humans; Isoxazoles; Nitriles; Organ Transplantation

2005

Trials

3 trial(s) available for isoxazoles and mna 715

ArticleYear
The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients.
    Transplantation, 2004, Jul-15, Volume: 78, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Alkynes; Drug Therapy, Combination; Female; Glucocorticoids; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Male; Middle Aged; Nitriles; Patient Compliance; Prednisolone; Tacrolimus; Treatment Outcome

2004
Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy.
    Transplantation, 2010, Oct-27, Volume: 90, Issue:8

    Topics: Algorithms; Alkynes; Creatinine; Cyclosporine; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Mycophenolic Acid; Nitriles; Patient Compliance; Polyomavirus Infections; Sirolimus; Tacrolimus; Time Factors; Viral Load

2010
A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation.
    BMC nephrology, 2012, Jul-26, Volume: 13

    Topics: Adult; Alkynes; Double-Blind Method; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Nitriles; Steroids; Tacrolimus

2012

Other Studies

79 other study(ies) available for isoxazoles and mna 715

ArticleYear
Efficacy of the malononitrilamide X 920715 as compared with leflunomide in cardiac allo- and xenotransplantation in rats.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Alkynes; Animals; Cricetinae; Drug Synergism; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Nitriles; Rats; Rats, Inbred Strains; Transplantation, Heterologous; Transplantation, Homologous

1996
Control of mouse-to-rat skin xenograft rejection by malononitrilamides.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous

1996
Malononitrilamides prevent the development of murine systemic lupus erythematosus-like diseases in BDF1 hybrid mice and MRL/lpr autoimmune mice.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Aging; Alkynes; Animals; Antibody Formation; Crosses, Genetic; Disease Models, Animal; Female; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles

1996
Malononitrilamides inhibit the development of various murine graft-vs-host diseases.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Alkynes; Animals; Graft vs Host Disease; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymphocyte Transfusion; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Nitriles; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Spleen; Splenomegaly; Time Factors; Transplantation, Homologous

1996
Acute skin graft rejection can be prevented and treated in rat models by malononitrilamides.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Acute Disease; Alkynes; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Time Factors

1996
Malononitrilamides inhibit T- and B-cell responsiveness.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Alkynes; Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; Humans; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Interleukin-4; Isoxazoles; Lymphocyte Activation; Mice; Nitriles; Rats; Spleen; T-Lymphocytes

1996
Malononitrilamides (MNA 279 and MNA 715) have therapeutic activity in acute and chronic relapsing experimental allergic encephalomyelitis (EAE).
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 2

    Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Isoxazoles; Kinetics; Nitriles; Rats; Rats, Inbred Lew; Recurrence

1997
Various graft vs. host diseases (GvHD) in rodents can be prevented and treated by malononitrilamides (MNAs).
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 2

    Topics: Alkynes; Animals; Graft vs Host Disease; Immunosuppressive Agents; Isoxazoles; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew

1997
Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 2

    Topics: Aging; Alkynes; Animals; Autoimmune Diseases; Female; Immunosuppressive Agents; Isoxazoles; Kinetics; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred DBA; Nitriles; Spleen; Splenomegaly

1997
Long-term xenograft survival by combination therapy of malononitrilamide MNA 715 with cyclosporine.
    Transplantation proceedings, 1997, Volume: 29, Issue:8

    Topics: Alkynes; Animals; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous

1997
Synergistic activity of malononitrilamides with cyclosporine to control and reverse xenograft rejection.
    International journal of tissue reactions, 1997, Volume: 19, Issue:3-4

    Topics: Alkynes; Animals; Antibody Formation; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Transplantation, Heterologous

1997
The alloreactivity in the popliteal lymph node (PLN) assay is regulated by malononitrilamides (MNAs).
    International journal of tissue reactions, 1997, Volume: 19, Issue:3-4

    Topics: Alkynes; Animals; Cell Division; Graft vs Host Reaction; Hybridization, Genetic; Immunosuppressive Agents; Isoantigens; Isoxazoles; Knee; Lymph Nodes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew

1997
The new immunosuppressants, the malononitrilamides MNA 279 and MNA 715, inhibit various graft-vs.-host diseases (GvHD) in rodents.
    Drugs under experimental and clinical research, 1997, Volume: 23, Issue:5-6

    Topics: Alkynes; Animals; Disease Models, Animal; Graft vs Host Disease; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew

1997
Therapeutic activity of malononitrilamides (MNA 279 and MNA 715) on acute and chronic, relapsing, experimental, allergic encephalomyelitis (EAE).
    Drugs under experimental and clinical research, 1997, Volume: 23, Issue:5-6

    Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred Strains; Nitriles; Rabbits; Rats; Rats, Inbred Lew

1997
Hyperacute skin allograft rejection in presensitized rats is abrogated by malononitrilamides.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Acute Disease; Alkynes; Animals; Graft Rejection; Immunization; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoantigens; Isoxazoles; Leflunomide; Lymphocyte Transfusion; Nitriles; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Structure-Activity Relationship; Time Factors; Transplantation, Homologous

1998
Inhibition of alloreactivity in the popliteal lymph node assay by malononitrilamides.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Alkynes; Animals; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lymph Nodes; Lymphocyte Activation; Lymphocyte Transfusion; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Homologous

1998
Malononitrilamides reduce IgM and IgG xenoantibodies and prolong skin xenograft survival in a mouse-to rat model.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Acute Disease; Alkynes; Animals; Antibodies, Heterophile; Antibody Formation; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous

1998
Comparative effects of malononitriloamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Adult; Alkynes; Animals; B-Lymphocytes; Cats; Dogs; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Macaca mulatta; Male; Nitriles; Rats; Rats, Inbred Lew; Species Specificity; T-Lymphocytes

1998
Synergism of the malononitrilamides 279 and 715 with cyclosporine A in the induction of long-term cardiac allograft survival.
    Transplant international : official journal of the European Society for Organ Transplantation, 1998, Volume: 11 Suppl 1

    Topics: Alkynes; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Species Specificity; Time Factors

1998
Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine.
    Transplant international : official journal of the European Society for Organ Transplantation, 1998, Volume: 11 Suppl 1

    Topics: Acute Disease; Alkynes; Animals; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Skin Transplantation

1998
Regulation of alloreactivity in the popliteal lymph node assay by the new immunosuppressants: malononitrilamides.
    Transplant international : official journal of the European Society for Organ Transplantation, 1998, Volume: 11 Suppl 1

    Topics: Alkynes; Animals; Graft vs Host Disease; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Lymph Nodes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew

1998
Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats.
    Transplant immunology, 1998, Volume: 6, Issue:2

    Topics: Alkynes; Animals; Antibody Specificity; Autoantibodies; Cyclosporine; Drug Synergism; Graft Rejection; Heart Transplantation; Immunization; Immunosuppressive Agents; Isoxazoles; Male; Myocardium; Nitriles; Rats; Rats, Inbred Strains

1998
Malononitrilamides 715 and 279 prolong rat cardiac allograft survival, reverse ongoing rejection, inhibit allospecific antibody production and interact positively with cyclosporin.
    Scandinavian journal of immunology, 1998, Volume: 48, Issue:4

    Topics: Alkynes; Aniline Compounds; Animals; Antibody Formation; Crotonates; Cyclosporine; Drug Interactions; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Hydroxybutyrates; Immunoglobulin Allotypes; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Toluidines; Transplantation, Homologous

1998
Malononitrilamides prevent and suppress allospecific antibody production.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Alkynes; Animals; Antibody Formation; Heart Transplantation; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Transplantation, Homologous

1998
Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Acrylamide; Acrylamides; Alkynes; Animals; Caproates; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Tacrolimus; Transplantation, Homologous

1998
Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibodies, Antinuclear; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Disease Models, Animal; Female; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Mutant Strains; Nitriles; Rats; Rats, Inbred Lew

1998
Modulation of immunoglobulin dysregulation in graft versus host-and systemic lupus erythematosus-like diseases by malononitrilamides.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibody Formation; Autoantibodies; Autoimmune Diseases; Caproates; Crosses, Genetic; Female; Glomerulonephritis; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymphocyte Transfusion; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles; Spleen; Transplantation, Homologous

1998
Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Acrylamide; Acrylamides; Administration, Oral; Alkynes; Animals; Caproates; Drug Synergism; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Tacrolimus; Time Factors; Transplantation, Heterologous

1998
Inhibition of PDGF-stimulated rat smooth muscle cell proliferation by MNA 279 and MNA 715.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Alkynes; Animals; Aorta, Thoracic; Cell Division; Cell Line; Dihydroorotate Dehydrogenase; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Platelet-Derived Growth Factor; Rats; Uridine

1998
Long-term cardiac allograft survival in mice treated with malononitrilamide 715.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Alkynes; Animals; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitriles; Tacrolimus; Time Factors; Transplantation, Homologous; Transplantation, Isogeneic

1998
Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay.
    Immunology letters, 1999, Apr-15, Volume: 67, Issue:3

    Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Biphenyl Compounds; Caproates; Crotonates; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Male; Nitriles; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Receptors, OX40; Receptors, Tumor Necrosis Factor; Toluidines; Tumor Necrosis Factor Receptor Superfamily, Member 7

1999
Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts.
    Transplant immunology, 1999, Volume: 7, Issue:3

    Topics: Alkynes; Animals; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Tacrolimus; Time Factors; Transplantation, Homologous

1999
Quilty effect in heterotopic cardiac allografts in malononitrilamide-treated rats.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:12

    Topics: Acrylamides; Alkynes; Animals; Caproates; Endocardium; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Myocardium; Nitriles; Rats; Transplantation, Heterotopic; Transplantation, Homologous

1999
Disease-modifying activity of malononitrilamides, derivatives of leflunomide's active metabolite, on models of rheumatoid arthritis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 2

    Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Crotonates; Dose-Response Relationship, Drug; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Lew; Toluidines

1999
Generation of O2- radicals in macrophages can be inhibited in vitro and in vivo by derivatives of leflunomide's primary metabolite.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 2

    Topics: Acrylamides; Alkynes; Animals; Caproates; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Free Radicals; Humans; Immunosuppressive Agents; Isoxazoles; Macrophages; Mice; Mice, Inbred NOD; Nitriles; Superoxides

1999
The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 2

    Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Caproates; Cell Division; Crotonates; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Platelet-Derived Growth Factor; Rats; Toluidines; Uridine

1999
Efficacy of malononitriloamide 279 and 715 in islet xenotransplantation: a study in the pig-to-rat model.
    Transplantation proceedings, 2000, Volume: 32, Issue:5

    Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Mycophenolic Acid; Nitriles; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous

2000
Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice.
    Transplantation proceedings, 2001, Volume: 33, Issue:3

    Topics: Alkynes; Animals; Cyclosporine; Diabetes Mellitus, Type 1; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred NOD; Nitriles; Rats; Transplantation, Heterologous

2001
Efficacy of malononitrilamide 715 as immunosuppressant, alone or in combination with cyclosporin, in allogeneic foetal rat pancreatic transplantation.
    Transplantation proceedings, 2001, Volume: 33, Issue:3

    Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Pancreas Transplantation; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Subrenal Capsule Assay; T-Lymphocytes; Transplantation, Homologous; Weight Gain; Weight Loss

2001
A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs.
    Surgery, 2002, Volume: 132, Issue:1

    Topics: Alkynes; Animals; Cyclosporine; Dogs; Female; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Tacrolimus

2002
In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates.
    Transplant international : official journal of the European Society for Organ Transplantation, 2003, Volume: 16, Issue:5

    Topics: Alkynes; Animals; Cell Division; Flow Cytometry; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Macaca fascicularis; Nitriles; T-Lymphocytes

2003
FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts.
    Transplantation, 2003, Apr-27, Volume: 75, Issue:8

    Topics: Alkynes; Animals; Antibody Formation; Gene Expression; Graft Rejection; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Kidney; Kidney Transplantation; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transforming Growth Factor beta; Transplantation, Homologous

2003
Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates.
    Transplantation, 2003, Apr-27, Volume: 75, Issue:8

    Topics: Alanine Transaminase; Alkynes; Animals; Aspartate Aminotransferases; Body Weight; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Liver; Male; Nitriles; Tacrolimus; Time Factors

2003
Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs.
    Transplantation, 2003, Apr-27, Volume: 75, Issue:8

    Topics: Alkynes; Animals; Cyclosporine; Dogs; Drug Therapy, Combination; Emulsions; Graft Survival; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Nitriles; Osmolar Concentration

2003
Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts.
    Transplantation, 2003, May-15, Volume: 75, Issue:9

    Topics: Alkynes; Animals; B-Lymphocytes; Cell Division; Drug Therapy, Combination; Female; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Lymphocyte Activation; Mice; Nitriles; Rats; Rats, Inbred Lew; Species Specificity; T-Lymphocytes; Tacrolimus; Transplantation, Homologous

2003
Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat.
    Transplantation, 2003, Jun-15, Volume: 75, Issue:11

    Topics: Acute Disease; Alkynes; Animals; Drug Synergism; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Myocardium; Nitriles; Rats; Rats, Inbred ACI; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Homologous

2003
Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection.
    Transplantation, 2003, Aug-15, Volume: 76, Issue:3

    Topics: Alkynes; Angiogenesis Inhibitors; Animals; Benzamides; Blood Vessels; Constriction, Pathologic; Dihydroorotate Dehydrogenase; Graft Rejection; Imatinib Mesylate; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Wistar; Recurrence; Tunica Intima; Uridine; Vascular Diseases

2003
Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
    Transplantation, 2003, Dec-15, Volume: 76, Issue:11

    Topics: Alkynes; Animals; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Models, Animal; Mycophenolic Acid; Nitriles; Rats; Transplantation, Homologous

2003
The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
    Transplantation, 2004, Feb-27, Volume: 77, Issue:4

    Topics: Alkynes; Animals; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Tacrolimus

2004
FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
    Transplantation, 2004, Jul-15, Volume: 78, Issue:1

    Topics: Acute Disease; Alkynes; Animals; Antineoplastic Agents; Cell Adhesion; Endothelial Cells; Graft Rejection; Heart Transplantation; In Vitro Techniques; Intercellular Adhesion Molecule-1; Iodine Radioisotopes; Isoxazoles; Lymphocytes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2004
FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.
    Transplantation, 2004, Dec-15, Volume: 78, Issue:11

    Topics: Acute Disease; Alkynes; Animals; Drug Therapy, Combination; Graft Rejection; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Liver; Liver Transplantation; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Homologous

2004
Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778.
    Antiviral research, 2005, Volume: 65, Issue:1

    Topics: Alkynes; Antiviral Agents; Cell Line; Cytomegalovirus; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Signal Transduction; Viral Plaque Assay; Viral Proteins; Virus Replication

2005
FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
    Transplant international : official journal of the European Society for Organ Transplantation, 2005, Volume: 18, Issue:2

    Topics: Acute Disease; Alkynes; Animals; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Isoxazoles; Male; Nitriles; P-Selectin; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Homologous; Up-Regulation; Vascular Cell Adhesion Molecule-1

2005
Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats.
    Transplantation, 2005, Jan-15, Volume: 79, Issue:1

    Topics: Alkynes; Animals; Antiviral Agents; Body Weight; Cytomegalovirus Infections; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Transplantation, Homologous; Uridine; Virus Replication

2005
The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells.
    Transplantation proceedings, 2005, Volume: 37, Issue:4

    Topics: Alkynes; Binding Sites; Dendritic Cells; Humans; Immunosuppressive Agents; Isoxazoles; Kinetics; Lipopolysaccharides; NF-kappa B; Nitriles; Oligodeoxyribonucleotides

2005
The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse.
    Transplantation proceedings, 2005, Volume: 37, Issue:4

    Topics: Alkynes; Cell Communication; Humans; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Nitriles; T-Lymphocytes

2005
2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis.
    Journal of vascular and interventional radiology : JVIR, 2005, Volume: 16, Issue:7

    Topics: Actins; Administration, Oral; Alkynes; Angioplasty, Balloon; Animals; Disease Models, Animal; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Isoxazoles; Male; Muscle, Smooth, Vascular; Nitriles; Rats; Rats, Inbred Lew; Tunica Intima

2005
In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2005, Volume: 19, Issue:18

    Topics: Alkynes; Chromatography, Liquid; Humans; Hydrogen-Ion Concentration; Hydroxylation; Isoxazoles; Mass Spectrometry; Molecular Structure; Nitriles; Optical Rotation; Stereoisomerism

2005
Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778.
    Transplantation, 2005, Oct-27, Volume: 80, Issue:8

    Topics: Alkynes; Antigens, CD; Cell Differentiation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Humans; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; NF-kappa B; Nitriles; T-Lymphocytes; Uridine

2005
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2005, Volume: 24, Issue:11

    Topics: Actins; Alkynes; Animals; Bronchiolitis Obliterans; Disease Models, Animal; Granulation Tissue; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Nitriles; Postoperative Complications; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Trachea

2005
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
    Transplant international : official journal of the European Society for Organ Transplantation, 2006, Volume: 19, Issue:4

    Topics: Alkynes; Animals; Disease Models, Animal; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Lung Diseases, Obstructive; Lung Transplantation; Male; Myocytes, Smooth Muscle; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Homologous; Transplantation, Isogeneic

2006
FK778: new cellular and molecular mechanisms of action.
    Transplantation proceedings, 2006, Volume: 38, Issue:3

    Topics: Alkynes; Animals; CD28 Antigens; Cell Adhesion; Endothelium, Vascular; Flow Cytometry; Isoxazoles; Lymphocyte Activation; Lymphocytes; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Antigen, T-Cell; Tumor Necrosis Factor-alpha; Uridine

2006
The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells.
    Blood, 2007, Jan-01, Volume: 109, Issue:1

    Topics: Adult; Alkynes; Antigens, CD; Antigens, Differentiation; CD4-Positive T-Lymphocytes; Cell Communication; Cell Division; Cells, Cultured; CTLA-4 Antigen; Cyclin-Dependent Kinase Inhibitor p27; Drug Evaluation, Preclinical; Forkhead Transcription Factors; Glucocorticoid-Induced TNFR-Related Protein; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Intracellular Signaling Peptides and Proteins; Isoantigens; Isoxazoles; L-Selectin; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Nitriles; Phosphorylation; Protein Processing, Post-Translational; Pyrimidines; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; Uridine

2007
Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Cardiology, 2007, Volume: 108, Issue:2

    Topics: Alkynes; Animals; Aorta, Abdominal; Carrier Proteins; Cell Movement; Cell Proliferation; Endothelium, Vascular; Graft Occlusion, Vascular; Hyperplasia; Immunosuppressive Agents; Isoxazoles; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Rats; Rats, Inbred Lew; RNA, Messenger; Sirolimus; Smad7 Protein; Tacrolimus; Transforming Growth Factor beta1; Tunica Intima; Vasodilation; Vasodilator Agents

2007
Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation.
    Journal of leukocyte biology, 2007, Volume: 81, Issue:1

    Topics: Alkynes; Antigen-Presenting Cells; Antimetabolites; Calcineurin; Cells, Cultured; Humans; Immunosuppressive Agents; Isoxazoles; Models, Immunological; NF-kappa B; Nitriles; T-Lymphocytes

2007
The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta.
    Transplantation proceedings, 2006, Volume: 38, Issue:8

    Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous

2006
The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression.
    Transplantation proceedings, 2006, Volume: 38, Issue:10

    Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Rats; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous; Transplantation, Isogeneic

2006
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:1

    Topics: Alkynes; Animals; Antibodies, Anti-Idiotypic; Aorta, Abdominal; Cricetinae; Disease Models, Animal; Endothelium, Vascular; Flow Cytometry; Graft Rejection; Humans; Immunoglobulin G; Immunoglobulin M; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Heterologous; Treatment Outcome

2007
Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
    Transplantation proceedings, 2007, Volume: 39, Issue:2

    Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tacrolimus; Trachea; Transplantation, Homologous

2007
The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model.
    Eye (London, England), 2007, Volume: 21, Issue:12

    Topics: Alkynes; Animals; Cornea; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Mycophenolic Acid; Nitriles; Postoperative Care; Postoperative Period; Rats; Rats, Inbred F344; Rats, Inbred Lew; Survival Analysis; Treatment Outcome

2007
The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.
    Transplantation, 2007, Mar-27, Volume: 83, Issue:6

    Topics: Alkynes; Animals; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Nitriles; Proteinuria; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Transforming Growth Factor beta; Transplantation, Homologous

2007
Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
    Transplantation, 2008, Mar-27, Volume: 85, Issue:6

    Topics: Alkynes; Animals; Aorta; Aortic Diseases; Chronic Disease; Cyclosporine; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred ACI; Transplantation, Homologous

2008
FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:11

    Topics: Alkynes; Animals; Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Male; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred WF; Risk Factors; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous

2008
Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein.
    International journal of molecular medicine, 2009, Volume: 23, Issue:3

    Topics: Alkynes; Antiviral Agents; DNA-Binding Proteins; G1 Phase; HeLa Cells; Human papillomavirus 16; Human papillomavirus 18; Humans; Isoxazoles; Nitriles; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Phosphorylation; Retinoblastoma Protein; S Phase; Tumor Suppressor Protein p53

2009
The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells.
    Transplantation proceedings, 2009, Volume: 41, Issue:5

    Topics: Adjuvants, Immunologic; Alkynes; Antigens, CD; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells; Flow Cytometry; Humans; Isoxazoles; Leflunomide; Nitriles; Phenotype; Reference Values; Sirolimus

2009
FK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model.
    Intervirology, 2009, Volume: 52, Issue:4

    Topics: Alkynes; Animals; Anti-Inflammatory Agents; Antiviral Agents; Herpesviridae Infections; Hyperplasia; Immunosuppressive Agents; Isoxazoles; Male; Muromegalovirus; Nitriles; Rats; Transplants; Tunica Intima

2009
Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2009, Volume: 7, Issue:4

    Topics: Age Factors; Aging; Alkynes; Animals; Antibody Formation; Autoantibodies; B-Lymphocytes; Dose-Response Relationship, Drug; Genes, bcl-2; Humans; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; T-Lymphocytes; Transplantation Tolerance

2009
Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
    Folia biologica, 2010, Volume: 56, Issue:2

    Topics: Alkynes; Animals; Blood Pressure; Disease Models, Animal; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Diseases; Leflunomide; Male; Nitriles; Placebos; Rats; Rats, Transgenic; Reperfusion Injury

2010
The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:1

    Topics: Alkynes; Cells, Cultured; Enzyme Inhibitors; HEK293 Cells; Hep G2 Cells; Hepatitis B virus; Humans; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Leflunomide; Mycophenolic Acid; Nitriles; Real-Time Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Virus Replication

2012