Compounds > isoxazoles
Page last updated: 2024-08-21

isoxazoles and kcc 009

isoxazoles has been researched along with kcc 009 in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (33.33)29.6817
2010's8 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Choi, K; Khosla, C; Kosek, JC; Omary, MB; Siegel, M; Strnad, P; Toivola, DM1
Choi, K; Jackson, EN; Khosla, C; Miller, CR; Piwnica-Worms, D; Rich, KM; Siegel, M; Yuan, L1
Behdad, A; Higashikubo, R; Khosla, C; Rich, KM; Siegel, M; Yuan, L1
Cao, L; Matei, D; Nakshatri, H; Petrache, I; Petrusca, DN; Satpathy, M1
Falasca, L; Khosla, C; Matic, I; Melino, G; Piacentini, M; Rinaldi, A; Sacchi, A1
Carboni, GL; Frese, S; Frese-Schaper, M; Sakai, T; Schardt, JA; Schmid, RA1
Broekelmann, TJ; Holmes, TC; Izaguirre, EW; Khosla, C; Mecham, R; Rich, KM; Watts, RE; Yuan, L; Zheng, H1
Banyard, D; Beazley, KE; Deasey, SC; Konoplyannikov, M; Lima, F; Nurminskaya, MV; Nurminsky, DI1
Konoplyannikov, M; Nurminskaya, M1
Bol, JGJM; Breve, JJP; Chrobok, NL; de Vries, HE; Drukarch, B; Karpuj, M; Kooij, G; Sestito, C; Steinman, L; van Buul, JD; Van Dam, AM; van der Pol, SMP; van Strien, ME; Wilhelmus, MM1
Budillon, A; Caraglia, M; Carbone, C; Di Gennaro, E; Milone, MR; Piro, G; Pucci, B1
Chihong, Z; Danying, W; Dong, Y; Huaying, S; Jianguo, F; Xiaoqian, Q1

Reviews

1 review(s) available for isoxazoles and kcc 009

ArticleYear
New therapeutic approaches to arterial calcification via inhibition of transglutaminase and β-catenin signaling.
    Current pharmaceutical design, 2014, Volume: 20, Issue:37

    Topics: Animals; beta Catenin; Enzyme Inhibitors; Humans; Isoxazoles; Signal Transduction; Transglutaminases; Vascular Calcification

2014

Other Studies

11 other study(ies) available for isoxazoles and kcc 009

ArticleYear
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
    FEBS letters, 2006, Apr-17, Volume: 580, Issue:9

    Topics: Animals; Cell Size; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Enzyme Inhibitors; GTP-Binding Proteins; Hepatomegaly; Humans; Inclusion Bodies; Isoxazoles; Keratins; Liver Diseases; Mice; Mice, Inbred C3H; Protein Glutamine gamma Glutamyltransferase 2; Proteins; Transglutaminases

2006
Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.
    Oncogene, 2007, Apr-19, Volume: 26, Issue:18

    Topics: Animals; Brain; Brain Neoplasms; Carmustine; Enzyme Inhibitors; Extracellular Matrix; Female; Fibronectins; Fluorescent Antibody Technique; Glioblastoma; GTP-Binding Proteins; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Protein Glutamine gamma Glutamyltransferase 2; RNA, Small Interfering; Survival Rate; Transglutaminases; Tumor Cells, Cultured

2007
Tissue transgluaminase 2 expression in meningiomas.
    Journal of neuro-oncology, 2008, Volume: 90, Issue:2

    Topics: Apoptosis; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fibronectins; Flow Cytometry; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; In Situ Nick-End Labeling; Isoxazoles; Meningeal Neoplasms; Meningioma; Protein Glutamine gamma Glutamyltransferase 2; Putrescine; Radiation; Tissue Culture Techniques; Transglutaminases; Tritium; Tumor Cells, Cultured

2008
Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling.
    Carcinogenesis, 2008, Volume: 29, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cisplatin; Female; GTP-Binding Proteins; Humans; Isoxazoles; Neoplasms, Glandular and Epithelial; NF-kappa B; Ovarian Neoplasms; Protein Glutamine gamma Glutamyltransferase 2; Signal Transduction; Transglutaminases; X-Linked Inhibitor of Apoptosis Protein

2008
Characterization of transglutaminase type II role in dendritic cell differentiation and function.
    Journal of leukocyte biology, 2010, Volume: 88, Issue:1

    Topics: Animals; Cell Differentiation; Cells, Cultured; Dendritic Cells; GTP-Binding Proteins; Humans; Interleukin-10; Interleukin-12; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Protein Glutamine gamma Glutamyltransferase 2; Transglutaminases

2010
Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5.
    FEBS letters, 2010, Jul-02, Volume: 584, Issue:13

    Topics: Apoptosis; Cell Line, Tumor; Flow Cytometry; GTP-Binding Proteins; Humans; Immunoblotting; Introns; Isoxazoles; Lung Neoplasms; Promoter Regions, Genetic; Protein Glutamine gamma Glutamyltransferase 2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Transglutaminases; Up-Regulation

2010
Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas.
    Journal of neuro-oncology, 2011, Volume: 103, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Fluorescent Antibody Technique; Glioblastoma; Humans; In Situ Nick-End Labeling; Isoxazoles; Mice; Radiation-Sensitizing Agents; Signal Transduction

2011
Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:1

    Topics: Animals; Aorta; Aortic Diseases; beta Catenin; Blood Pressure; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GTP-Binding Proteins; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Osteogenesis; Phosphorylation; Protein Glutamine gamma Glutamyltransferase 2; Quercetin; Rats; Rats, Wistar; Signal Transduction; Transglutaminases; Vascular Calcification; Warfarin

2013
Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration.
    Brain, behavior, and immunity, 2015, Volume: 50

    Topics: Aged; Aged, 80 and over; Animals; Cell Movement; Cerebral Cortex; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Female; GTP-Binding Proteins; Humans; Inflammation Mediators; Isoxazoles; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Myelin Sheath; Protein Glutamine gamma Glutamyltransferase 2; Rats; RNA, Messenger; Spinal Cord; Spleen; T-Lymphocytes; Transglutaminases

2015
Tissue transglutaminase (TG2) is involved in the resistance of cancer cells to the histone deacetylase (HDAC) inhibitor vorinostat.
    Amino acids, 2017, Volume: 49, Issue:3

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; HT29 Cells; Humans; Hydroxamic Acids; Isoxazoles; MCF-7 Cells; Protein Glutamine gamma Glutamyltransferase 2; RNA, Small Interfering; Signal Transduction; Transglutaminases; Vorinostat

2017
Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Dec-21, Volume: 22

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Isoxazoles; Lung Neoplasms; Protein Glutamine gamma Glutamyltransferase 2; Radiation-Sensitizing Agents; Radiation, Ionizing; Transglutaminases; Tumor Suppressor Protein p53

2016