isoxazoles has been researched along with gw 4064 in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 51 (27.57) | 29.6817 |
| 2010's | 116 (62.70) | 24.3611 |
| 2020's | 18 (9.73) | 2.80 |
| Authors | Studies |
|---|---|
| Chandra, G; Creech, KL; Fivush, AM; Haffner, CD; Jones, SA; Lewis, MC; Maloney, PR; Moore, LB; Parks, DJ; Plunket, KD; Willson, TM; Wilson, JG | 1 |
| Anisfeld, AM; Edwards, PA; Goodwin, B; Jones, SA; Kast, HR; Kliewer, S; Stoltz, CM; Tarr, PT; Tontonoz, P; Willson, TM | 1 |
| Claudel, T; Dallongeville, J; Duez, H; Fruchart, JC; Hum, DW; Kosykh, V; Kuipers, F; Sirvent, A; Staels, B; Sturm, E; Torra, IP | 1 |
| Adams, A; Cui, J; Huang, L; Lo, JL; Meinke, PT; Metzger, E; Wright, SD; Yu, J; Zhao, A | 1 |
| Berdy, S; Kerr, TA; Redder, T; Russell, DW; Saeki, S; Schaefer, K; Schneider, M; Schwarz, M; Shan, B | 1 |
| Bundman, D; Chua, SS; Han, Y; Heyman, RA; Karin, M; Kim, CS; Lee, YK; Moore, DD; Thevananther, S; Wang, L; Wei, P | 1 |
| Hu, X; Lala, DS; Li, S; Meier, J; Wu, J; Xia, C | 1 |
| Claudel, T; Duval, C; Fruchart, JC; Kosykh, V; Pineda Torra, I; Staels, B | 1 |
| Blevins, RA; Cui, J; de Pedro, N; Hrywna, Y; Huang, L; Lew, JL; Peláez, F; Thompson, JR; Wright, SD; Yu, J; Zhang, T; Zhao, A | 1 |
| Billin, AN; Bisi, J; Donahee, M; Goodwin, B; Holt, JA; Jones, SA; Kliewer, SA; Kozarsky, KF; Luo, G; Mansfield, TA; McNeill, YY; Wang, DY | 1 |
| Barbier, O; Claudel, T; Duran-Sandoval, D; Fruchart, J; Fruchart, JC; Gonzalez, FJ; Inoue, Y; Kosykh, V; Staels, B | 1 |
| Binz, J; Dennis, S; Desai, B; Goodwin, B; Jones, SA; Kliewer, SA; Liu, Y; Luo, G; MacKenzie, KI; Mansfield, TA; Numerick, MJ | 1 |
| Brozek, J; Claudel, T; Darteil, R; Fruchart, JC; Hum, DW; Kosykh, V; Martin, G; Sirvent, A; Staels, B | 1 |
| Blättler, S; Gnerre, C; Kaufmann, MR; Looser, R; Meyer, UA | 1 |
| Bookout, AL; Mangelsdorf, DJ; Moschetta, A | 1 |
| Bramlett, KS; Burris, TP; Christe, ME; Cook, T; Ficorilli, J; Michael, LF; Savkur, RS; Stayrook, KR | 1 |
| Folkers, G; Hagenbuch, B; Huber, R; Kaseda, C; Kashima, T; Meier, PJ; Moro, S; Yarim, M | 1 |
| Borges-Marcucci, LA; Evans, MJ; Harnish, DC; Qin, P | 1 |
| Barbu, V; Chignard, N; Finzi, L; Housset, C; Mergey, M; Paul, A; Tiret, E | 1 |
| Edwards, PA; Gonzalez, FJ; Lee, FY; Lee, H; Nelson, SF; Zhang, Y | 1 |
| Björkhem, I; Eggertsen, G; Einarsson, C; Gåfvels, M; Murphy, C; Parini, P; Wang, J | 1 |
| Eloranta, JJ; Kullak-Ublick, GA; Landrier, JF; Vavricka, SR | 1 |
| Edwards, PA; Kast-Woelbern, HR; Lusis, AJ; Shih, DM; Wong, J; Xia, YR | 1 |
| Barrera, G; Edwards, PA; Gonzalez, FJ; Lee, FY; Lee, H; Vales, C; Willson, TM; Zhang, Y | 1 |
| Abdelkarim, M; Cariou, B; Caron, S; Duran-Sandoval, D; Fruchart, JC; Gonzalez, FJ; Grefhorst, A; Kuipers, F; Staels, B; Torpier, G; van Dijk, TH; van Harmelen, K | 1 |
| Downes, M; Inagaki, T; Kliewer, SA; Lee, YK; Mangelsdorf, DJ; Moschetta, A; Peng, L; Repa, JJ; Richardson, JA; Shelton, JM; Yu, RT; Zhao, G | 1 |
| Doggrell, SA | 1 |
| Jung, D; Mangelsdorf, DJ; Meyer, UA | 1 |
| Bishop-Bailey, D; Carpenter, R; Korbonits, M; Swales, KE; Walsh, DT; Warner, TD | 1 |
| Chouinard, M; Cox, AL; Ficorilli, J; Gao, H; Hu, T; Li, S; Marcelo, M; Michael, LF; Michael, MD; Ryan, TP; Sipes, P | 1 |
| Hashimoto, Y; Kainuma, M; Makishima, M; Miyachi, H | 1 |
| Auwerx, J; Cummins, CL; Houten, SM; Mangelsdorf, DJ; Volle, DH | 1 |
| Caruso, D; Crestani, M; De Fabiani, E; Galmozzi, A; Gilardi, F; Godio, C; Mitro, N; Scotti, E; Vigil Chacon, AB | 1 |
| Dawson, PA; Gerard, RD; Inagaki, T; Jung, D; Kliewer, SA; Mangelsdorf, DJ; Moschetta, A | 1 |
| Billiar, TR; Gao, X; He, F; Kuruba, R; Li, J; Li, S; Pitt, BR; Wilson, A; Xie, W; Zhang, Q | 1 |
| Bishop-Bailey, D; Li, YT; Swales, KE; Thomas, GJ; Warner, TD | 1 |
| Cariou, B; Caron, S; Costet, P; Kourimate, S; Krempf, M; Langhi, C; Le May, C; Staels, B | 1 |
| Osborne, TF; Shin, DJ | 1 |
| Chen, WD; Forman, BM; Huang, W; Huang, X; Lai, L; Wang, YD; Yang, F | 1 |
| Gao, X; Gong, W; He, F; Jiang, Y; Kuruba, R; Li, J; Li, S; Li, Y; Xie, W; Zhang, Q | 1 |
| Akwabi-Ameyaw, A; Bass, JY; Caldwell, RD; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Jones, SA; Kaldor, I; Liu, Y; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB | 1 |
| Hori, M; Kida, T; Murata, T; Ozaki, H | 1 |
| Chiang, JY; Li, T; Owsley, E; Song, KH; Strom, S | 1 |
| Alvarez, L; Hierro, L; Jara, P; Martínez-Fernández, P | 1 |
| Benson, GM; Bleicher, K; Chen, L; Feng, S; Grether, U; Hong, D; Kuhn, B; Martin, RE; Plancher, JM; Richter, H; Rudolph, MG; Wang, Z; Yang, M; Zhang, Z | 1 |
| Aleksunes, LM; Cui, YJ; Goedken, MJ; Klaassen, CD; Tanaka, Y | 1 |
| Bass, JY; Caldwell, RD; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Parks, DJ; Todd, D; Williams, SP; Wisely, GB | 1 |
| Dullens, SP; Mariman, EC; Mensink, RP; Plat, J | 1 |
| Akwabi-Ameyaw, A; Bass, JY; Bruce Wisely, G; Caldwell, RD; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP | 1 |
| Gao, X; Kuruba, R; Li, J; Li, S; Liu, Y; Pitt, B; Poloyac, S; Wilson, A; Xie, W | 1 |
| Los, EL; Lukovac, S; Rings, EH; Stellaard, F; Verkade, HJ | 1 |
| Hinton, DE; Howarth, DL; Kullman, SW; Law, JM; Law, SH; Mondon, JA | 1 |
| Andò, S; Bonofiglio, D; Catalano, S; Giordano, C; Gu, G; Lanzino, M; Malivindi, R; Panno, ML; Panza, S; Sisci, D | 1 |
| Kemper, JK; Lee, J; Miao, J; Mo, YY; Padhye, A; Sharma, A; Song, G; Wang, L | 1 |
| Chiang, JY; Li, T; Owsley, E; Song, KH | 1 |
| Jiang, T; Levi, M; Wang, XX | 1 |
| Bouchaert, E; Caron, S; Derudas, B; Dumont, J; Helleboid-Chapman, A; Kerr-Conte, J; Lucas, A; Pattou, F; Popescu, IR; Staels, B; Vandewalle, B | 1 |
| Abel, U; Burnet, M; Deuschle, U; Hambruch, E; Hoffmann, T; Hornberger, M; Kinzel, O; Kremoser, C; Perović-Ottstadt, S; Schlüter, T; Schulz, A; Steeneck, C | 1 |
| Eggertsen, G; Gåfvels, M; Jiang, ZY; Kannisto, K; Ovchinnikova, O; Parini, P; Paulsson-Berne, G; Slätis, K | 1 |
| Gao, X; Kuruba, R; Li, J; Li, S; Wilson, A; Zhang, Y | 1 |
| Boehme, S; Chiang, JY; Ellis, E; Guo, G; Kong, B; Li, T; Matozel, M; Nilsson, LM | 1 |
| Anakk, SP; Arora, A; Bandyopadhyay, A; Banerjee, P; Chattopadhyay, N; Chaturvedi, RK; Dwivedi, SK; Gaikwad, AN; Kukshal, V; Kumari, R; Lundåsen, T; Mishra, DP; Mishra, JS; Moore, DD; Ramachandran, R; Sanyal, S; Shah, P; Siddiqi, MI; Singh, N; Tripathi, S; Trivedi, AK; Tyagi, AM | 1 |
| Andò, S; Barone, I; Bonofiglio, D; Catalano, S; Fuqua, SA; Gelsomino, L; Giordano, C; Panza, S; Rizza, P; Vizza, D | 1 |
| Kim, SG; Kim, YM; Kim, YW; Noh, K | 1 |
| Arita, E; Auwerx, J; Horai, Y; Houten, SM; Itoh, H; Mataki, C; Morimoto, K; Sato, H; Schoonjans, K; Sugizaki, T; Tanigawara, Y; Watanabe, M | 1 |
| Chiang, PC; Ghosh, S; Heitmeier, MR; Thompson, DC | 1 |
| Akwabi-Ameyaw, A; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Mencarelli, A; Palladino, G; Renga, B | 1 |
| Anderson, D; Chen, L; Collins, J; Croom, D; Gedulin, B; Hamlet, K; Liu, Y; McNulty, J; Nystrom, C; Rajpal, D; Ross, S; Smith, C; Yao, X; Young, A | 1 |
| Chang, KO; Kim, Y | 1 |
| Dai, J; Dong, Y; Shi, Y; Wang, H; Wang, J; Zhang, Y | 1 |
| Araya, JJ; Chen, T; Guo, GL; Li, G; Lin, W; Timmermann, BN | 1 |
| Accili, D; Haeusler, RA; Klaassen, CD; Pratt-Hyatt, M; Welch, CL | 1 |
| Gao, E; He, B; Koch, W; Lau, WB; Ma, XL; Pu, J; Shan, P; Wang, X; Wang, Y; Yuan, A | 1 |
| Hashimoto, Y; Hayashi, H; Misawa, T; Sugiyama, Y | 1 |
| Guo, GL; Inaba, Y; Kong, B; Li, G; Liu, J; Thomas, AM; Williams, JA; Xie, W | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Fiorucci, S; Francisci, D; Mencarelli, A; Renga, B; Schiaroli, E | 1 |
| Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Shirakami, Y; Tsurumi, H; Yasuda, Y | 1 |
| Hashimoto, Y; Hayashi, H; Makishima, M; Misawa, T; Sugiyama, Y | 1 |
| Groen, AK; Hoekstra, M; Li, Z; Oosterveer, MH; Van Berkel, TJ; van der Sluis, RJ | 1 |
| Gong, W; He, F; Huang, G; Xu, Z; Zeng, Y; Zhao, Y; Zhou, P | 1 |
| Fu, J; Li, WH; Liu, GX; Tang, Y; Zheng, MY | 1 |
| Abel, U; Deuschle, U; Kinzel, O; Kremoser, C; Schlüter, T; Schüler, J; Schulz, A | 1 |
| Cheng, F; Fu, J; Li, W; Liu, G; Tang, Y; Zhang, J; Zheng, M | 1 |
| Peng, Z; Raufman, JP; Xie, G | 1 |
| Andò, S; Barone, I; Bonofiglio, D; Bossi, G; Catalano, S; Giordano, C; Lanzino, M; Malivindi, R; Mauro, L; Panza, S; Sirianni, R; Sisci, D | 1 |
| Ding, X; Fang, C; Jia, K; Zhang, P; Zhang, QY; Zhou, X | 1 |
| Gao, M; Huang, Y; Liu, D; Ma, Y; Yan, L | 1 |
| Deng, Y; Huang, J; Liu, S; Lu, Y; Ning, G; Shen, W; Wang, H; Yang, J; Yang, Y; Zhang, D; Zhang, Q; Zhang, R; Zhu, R | 1 |
| Baldán, Á; Civelek, M; de Aguiar Vallim, TQ; Edwards, PA; Esau, C; Kim, T; Tarling, EJ | 1 |
| Briz, O; Herraez, E; Marin, JJ; Muntané, J; Vaquero, J | 1 |
| Chen, T; Forman, BM; Lin, W; Yu, DD | 1 |
| Rader, DJ; Vickers, KC | 1 |
| Cai, K; Sewer, MB | 1 |
| Haro, D; Langhi, C; Marrero, PF; Pedraz-Cuesta, E; Rodríguez, JC | 1 |
| Amu, S; Aviello, G; Donowitz, M; Fallon, PG; Keating, N; Keely, SJ; Mroz, MS; Sarker, R; Ward, JB | 1 |
| Dominguez, M; Marin, JJ; Monte, MJ; Muntané, J; Vaquero, J | 1 |
| Lee, JH; Raslan, AA; Shin, J; Shin, YK; Sohn, YC | 1 |
| Castelli, R; Giorgio, C; Hassan-Mohamed, I; Incerti, M; Lodola, A; Pala, D; Russo, S; Tognolini, M | 1 |
| Dong, J; Guo, D; Jiang, Y; Li, L; Liu, H; Liu, X; Peng, J; Wang, Y; Zhang, Y | 1 |
| Peng, Y; Xin, X; Zhang, S; Zhang, Y; Zhong, M; Zhu, W | 1 |
| Chandra, S; Chattopadhyay, N; Dwivedi, SK; Gurjar, A; Jagavelu, K; Kumar, H; Manhas, A; Mishra, JS; Sanyal, S; Siddiqi, MI; Singh, AK; Singh, N; Trivedi, AK; Yadav, M; Yadav, PN | 1 |
| Brzozowski, T; Jasnos, K; Krzysiek-Maczka, G; Kwiecien, S; Magierowski, M; Ptak-Belowska, A; Sliwowski, Z; Surmiak, M | 1 |
| Broderick, D; Hsu, V; Jiang, Y; Maier, CS; Yang, L | 1 |
| Eigner, K; Fruhwürth, S; Röhrl, C; Stangl, H | 1 |
| Chen, M; Fu, BQ; Ma, X; Tao, LS; Xu, YP; Yao, J; Zhou, CS | 1 |
| Choi, SE; Fu, T; Kang, Y; Kemper, B; Kemper, JK; Kumar, S; Li, Y; Ma, J; Seok, S; Sun, X; Yoon, G; Zhong, W; Zhu, R | 1 |
| Peng, Y; Xin, XM; Yang, GL; Zhang, YL; Zhong, MX; Zhu, W | 1 |
| Chen, A; Cong, Y; Deng, Y; Wang, X; Xu, Y; Yin, Y; Zhao, C | 1 |
| Alcorn, JL; Batra, S; Blackburn, MR; Fallon, MB; Hu, B; Wu, W; Yang, W; Zhang, J | 1 |
| Barettino, D; D'Ocon, P; Masiá, S; Montó, F; Moreno, L; Muedra, V; Pérez, P | 1 |
| Chen, WD; Guo, C; Huang, W; Kong, J; Li, C; Li, Y; Long, X; Qi, H; Shen, H; Wang, X; Wang, YD; Yuan, F | 1 |
| Boggs, S; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Kaldor, I; Parks, DJ; Smalley, TL | 1 |
| Ahn, H; de Aguiar Vallim, TQ; Tarling, EJ | 1 |
| Jeong, H; Koh, KH; Ning, M; Pan, X | 1 |
| Drews, G; Düfer, M; Kähny, V; Krippeit-Drews, P; Peter, A; Schittenhelm, B; Wagner, R | 1 |
| Jeong, H; Pan, X; Zhang, S | 1 |
| Jeong, H; Lee, YK; Pan, X | 1 |
| Flesch, D; Gabler, M; Gomez, RC; Lill, A; Merk, D; Schneider, G; Schubert-Zsilavecz, M; Stark, H; Steri, R | 1 |
| Hu, M; Pan, Y; Tang, LJ; Zhou, H; Zhou, HG | 1 |
| Chang, S; Choi, HS; Choi, SM; Lee, MO; Lee, S; Moon, Y; Park, B; Park, H | 1 |
| Chen, J; Chen, LL; Fu, HA; Hu, LH; Liu, P; Shen, X; Xu, X; Zhu, ZY | 1 |
| Chen, L; Chen, X; Ding, L; Fu, X; Huang, W; Liu, Y; Lou, G; Xu, H; Yao, Y | 1 |
| Fu, X; Huang, M; Huang, Z; Jin, J; Qiu, Y; Sun, X; Wang, W; Zhao, Z | 1 |
| Chen, X; Li, S; Wang, BM; Zhou, L | 1 |
| Chen, S; Guo, F; He, F; Huang, G; Jiang, P; Lyu, X; Wang, S; Xu, Z; Zeng, Y; Zhang, Y; Zhao, X; Zheng, P | 1 |
| Chen, Y; Feng, B; Gong, Y; Mu, J; Qin, Z; Shi, Z; Yuan, F; Zhang, J; Zhao, Y; Zhou, B | 1 |
| Byun, S; Fu, T; Kemper, B; Kemper, JK; Kim, DH; Kim, YC; Seok, S; Suino-Powell, K; Xu, HE | 1 |
| Alasmael, N; Meira, LB; Mohan, R; Plant, NJ; Swales, KE | 1 |
| Amin, SG; Bisson, WH; Brocker, CN; Desai, D; Gavrilova, O; Gonzalez, FJ; Jiang, C; Krausz, KW; Li, J; Liu, Y; Lv, Y; Patterson, AD; Shi, J; Xie, C | 1 |
| Cao, L; Cheng, X; Hao, H; Wang, G; Wang, H; Wu, M; Wu, Y; Xie, W; Xie, Y | 1 |
| Baptissart, M; Baron, S; Caira, F; de Haze, A; Martinot, E; Rouaisnel, B; Schoonjans, K; Sédes, L; Vega, A; Volle, DH | 1 |
| Andò, S; Barone, I; Bonofiglio, D; Catalano, S; Gelsomino, L; Giordano, C; Lanzino, M; Malivindi, R; Mauro, L; Panno, ML; Panza, S; Pellegrino, M; Rago, V; Vircillo, V | 1 |
| Buist-Homan, M; Faber, KN; Groen, AK; Koehorst, M; Moshage, H; Verhaag, EM | 1 |
| Chen, W; Chu, H; Hou, Z; Huang, Q; Li, Q; Man, M; Wang, J; Wang, W; Zhan, M | 1 |
| Fu, X; Guan, M; Liu, Q; Liu, R; Pan, H; Sun, C; Wong, CW; Yang, M | 1 |
| Aleksunes, LM; Buckley, B; Buckley, K; Guo, GL; Kong, B; Moscovitz, JE | 1 |
| Alawad, AS; Levy, C | 1 |
| Ali, MS; Bishop-Bailey, D; Bye, AP; Dombrowicz, D; Dorchies, E; Flora, GD; Gibbins, JM; Kriek, N; Molendi-Coste, O; Moraes, LA; Sage, T; Sasikumar, P; Staels, B; Unsworth, AJ; Vaiyapuri, S | 1 |
| Haga, S; Ozaki, M | 1 |
| Hardt, C; Häussinger, D; Honke, N; Keitel, V; Krings, C; Lang, KS; Lang, PA; Shaabani, N | 1 |
| Anitha, M; Gao, X; Gonzalez, FJ; Jiang, C; Krausz, KW; Patterson, AD; Shi, J; Sun, D; Sun, L; Takahashi, S; Wang, T; Xie, C | 1 |
| Guo, L; Lu, D; Wang, S; Wu, B; Xie, Q | 1 |
| Albrecht, S; Fleck, AK; Hucke, S; Kirchberg, I; Klotz, L; Kuhlmann, T; Liebmann, M | 1 |
| Cao, L; Che, Y; Gonzalez, FJ; Hao, H; Jiang, C; Takahashi, S; Wang, G; Zhang, S | 1 |
| Chow, MD; Guo, GL; Lee, YH | 1 |
| Allan, HE; Bye, AP; Crescente, M; Desborough, MJR; Gibbins, JM; Jones, CI; Kriek, N; Sage, T; Tannetta, DS; Unsworth, AJ; Warner, TD; Yaqoob, P | 1 |
| Lee, TY; Liao, JF; Liu, HM | 2 |
| Chi, Z; Guo, C; Huang, B; Wang, D; Wu, Y; Xia, D; Xie, S | 1 |
| Guo, L; Lu, D; Wang, S; Wu, B; Yuan, X | 1 |
| Cai, X; Chen, ZL; Jin, F; Li, G; Li, HR; Luo, L; Ma, Q; Wang, Y; Xue, J; Yang, F; Zhao, L; Zhou, X | 1 |
| Chen, T; Dong, B; Huang, F; Jia, W; Lei, S; Li, D; Qu, C; Rajani, C; Xie, G; Zhang, Y; Zhao, A; Zheng, X | 1 |
| Chen, X; Gao, E; Guo, Y; Li, C; Li, Y; Liu, Y; Tao, L; Wang, H; Wang, S; Wang, W; Xia, Y; Xiong, Z; Xu, X; Yan, W; Zhang, F; Zhang, J; Zhang, L; Zhang, X; Zhao, H; Zhao, S | 1 |
| Kainuma, M; Makishima, M; Sano, K; Takada, I | 1 |
| Byun, S; Guo, G; Kemper, B; Kemper, JK; Kim, DH; Kim, YC; Kong, B; Ryerson, D; Sun, H; Xu, HE; Yau, P | 1 |
| Andò, S; Barone, I; Bonofiglio, D; Bruno, G; Caruso, A; Catalano, S; Gelsomino, L; Giordano, C; Győrffy, B; Rinaldi, A; Romeo, F; Tarallo, R; Vircillo, V | 1 |
| Cai, X; Chen, D; Chen, M; Liu, L; Luo, G; Qiu, R; Xiang, H; You, Q | 1 |
| Bijsmans, ITGW; van de Graaf, SFJ; van de Wiel, SMW; van Mil, SWC | 1 |
| Jiang, JD; Li, H; Li, JR; Lv, XQ; Peng, ZG; Wu, ZY | 1 |
| Bae, EH; Choi, HI; Kim, CS; Kim, DH; Kim, SW; Ma, SK; Park, JS | 1 |
| Baruchet, M; Casals-Casas, C; Desvergne, B; Naldi, A; Pradervand, S; Trang, KB; Wigger, L | 1 |
| Hussner, J; Issa, A; Malagnino, V; Meyer Zu Schwabedissen, HE; Midzic, A | 1 |
| Hotta, M; Ishino, K; Kudo, M; Naito, Z; Sakatani, T; Wada, R; Yamada, T; Yokoyama, Y; Yoshida, H | 1 |
| Fujimori, K; Gohda, K; Iguchi, Y; Teno, N; Yamashita, Y | 1 |
| Tao, J; Wu, B; Xing, C | 1 |
| Chen, B; Fan, Z; Li, L; Li, N; Ye, Q; Yue, J; Zhao, H | 1 |
| Chen, PH; Chiu, TC; Huang, SC; Hung, TM; Kao, YH; Lee, HM; Lee, PH; Lin, YC; Sun, CK; Tsai, MS | 1 |
| Adeli, K; Anakk, S; Baker, C; Dean, AE; Farr, S; Hoffman, S; Masoudpoor, H; Stankovic, B; Taher, J | 1 |
| Chen, W; Ge, K; Han, X; Huang, F; Huang, Y; Jia, W; Rajani, C; Wang, S; Yu, H; Zhao, A; Zheng, X; Zhu, J | 1 |
| Lee, A; Li, JY; Lu, YX; Owyang, C; Wu, X; Zhou, SY | 1 |
| Belling, KG; Brunak, S; Jakobsson, ME; Niss, K; Olsen, JV; Westergaard, D | 1 |
| Li, X; Li, Z; Lin, X; Luo, G; Xiang, H; Xiao, M; Zhang, D | 1 |
| Chen, M; Dong, Z; Lan, X; Liao, Z; Ma, Y; Wang, G; Wei, X | 1 |
| Bao, Y; Chen, T; Dong, B; Hu, C; Jia, W; Jiang, C; Jiang, R; Kuang, J; Lan, K; Li, D; Li, H; Li, M; Lu, A; Rajani, C; Ren, Z; Sun, D; Wang, S; Wang, X; Wu, J; Wu, Q; Xia, J; Xie, G; Zhao, A; Zhao, M; Zheng, X | 1 |
| Cha, DR; Cha, JJ; Han, JY; Han, SY; Kang, YS; Song, HK | 1 |
| Chen, Z; Guo, J; Mu, M; Qin, X; Sun, X; Xu, Z; Yang, K; Yu, J; Zhao, C; Zheng, J | 1 |
| Brunst, S; Ebert, R; Helmstädter, M; Kramer, JS; Merk, D; Proschak, E; Schierle, S; Steinhilber, D | 1 |
| Chien, D; Dawson, PA; Dong, X; Fauler, G; Fickert, P; Gilmer, JF; Moustafa, T; Truong, JK; van de Graaf, SFJ; van de Wiel, SMW; Yin, L; Zaufel, A | 1 |
| Cao, S; Chen, X; Jiang, L; Li, Y; Meng, X; Sun, L; Xuan, H | 1 |
| Bertolini, A; Bloks, VW; Chen, S; de Wit, S; Havinga, R; Jašprová, J; Jonker, JW; Mennillo, E; Rettenmeier, E; Schreuder, AB; Struik, D; Tukey, RH; Valášková, P; van der Schoor, LWE; Verkade, HJ; Vítek, L; Weber, AA | 1 |
| Aguiriano-Moser, V; Gallistl, S; Greimel, T; Haidl, H; Holasek, S; Jahnel, J; Meier-Allard, N; Meinel, K; Panzitt, K; Pohl, S; Schlagenhauf, A; Strini, T; Tischitz, M; Wagner, M; Zobel, J | 1 |
| Anderson, AL; Balasubramaniyan, N; D'Alessandro, A; Devereaux, MW; El Kasmi, KC; Ghosh, S; Orlicky, DJ; Shearn, CT; Sokol, RJ; Suchy, FJ | 1 |
| Chen, X; Chen, Y; Dai, S; Guo, M; Jiang, L; Liu, X; Qu, L; Wei, H | 1 |
| Cai, C; Chu, T; Dong, S; Hu, W; Kang, F; Li, Y | 1 |
6 review(s) available for isoxazoles and gw 4064
| Article | Year |
|---|---|
New targets in and potential treatments for cholesterol gallstone disease.
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Cholic Acids; Cyclic N-Oxides; DNA-Binding Proteins; Gallstones; Humans; Isoxazoles; Mucins; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tropanes | 2006 |
Nuclear hormone receptors in diabetic nephropathy.
Topics: Animals; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Heat-Shock Proteins; Hepatocyte Nuclear Factor 4; Humans; Hypolipidemic Agents; Isoxazoles; Liver X Receptors; Orphan Nuclear Receptors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Thiazolidinediones; Transcription Factors; Vitamin D | 2010 |
[Progress in the ligands and their complex structures of farnesoid X receptor].
Topics: Animals; Anticholesteremic Agents; Azepines; Benzene Derivatives; Chenodeoxycholic Acid; Crystallization; Humans; Indoles; Isoxazoles; Ligands; Molecular Structure; Multienzyme Complexes; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2012 |
FXR Agonists: From Bench to Bedside, a Guide for Clinicians.
Topics: Animals; Azepines; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholestasis; Drug Evaluation, Preclinical; Gastrointestinal Agents; Hepatitis, Autoimmune; Humans; Hypertension, Portal; Indoles; Isoxazoles; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Liver Diseases; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Ursodeoxycholic Acid | 2016 |
The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Topics: Azepines; Bile Acids and Salts; Carcinoma, Hepatocellular; Disease Progression; Energy Metabolism; Gene Expression Regulation; Glucose; Humans; Indoles; Isoxazoles; Liver; Liver Cirrhosis; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Receptors, Steroid | 2017 |
Effects of active farnesoid X receptor on GLUTag enteroendocrine L cells.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; Data Mining; Enteroendocrine Cells; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; Glucagon-Like Peptide 1; Glucose; Glycolysis; Humans; Isoxazoles; Mitochondria; Protein Interaction Maps; Proteome; Receptors, Cytoplasmic and Nuclear; Transcriptome | 2020 |
179 other study(ies) available for isoxazoles and gw 4064
| Article | Year |
|---|---|
Identification of a chemical tool for the orphan nuclear receptor FXR.
Topics: Animals; Biological Availability; Cell Line; Cell-Free System; Combinatorial Chemistry Techniques; DNA-Binding Proteins; Humans; Isoxazoles; Mice; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transfection; Triglycerides | 2000 |
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
Topics: Animals; Base Sequence; Bile Acids and Salts; Blotting, Northern; Cell Line; Cell Nucleus; Cells, Cultured; Constitutive Androstane Receptor; DNA-Binding Proteins; Drug Resistance, Multiple; Genes, Reporter; Hepatocytes; Humans; Isoxazoles; Ligands; Liver; Membrane Transport Proteins; Mice; Models, Biological; Molecular Sequence Data; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nucleic Acid Hybridization; Phenobarbital; Pregnane X Receptor; Promoter Regions, Genetic; Protein Binding; Protein Transport; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2002 |
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
Topics: Animals; Apolipoprotein A-I; Bile Acids and Salts; Binding Sites; Blood Proteins; Cells, Cultured; Cholestasis, Intrahepatic; Chromosome Mapping; Dimerization; DNA-Binding Proteins; gamma-Glutamyltransferase; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Response Elements; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Escherichia coli; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Isoxazoles; Lithocholic Acid; Mixed Function Oxygenases; Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rifampin; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2002 |
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholestyramine Resin; DNA-Binding Proteins; Feedback; Gene Expression Regulation; Isoxazoles; Liver X Receptors; Male; Mice; Mice, Knockout; Microsomes, Liver; mRNA Cleavage and Polyadenylation Factors; Nuclear Proteins; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; RNA-Binding Proteins; Steroid Hydroxylases; Transcription Factors; Triglycerides | 2002 |
Redundant pathways for negative feedback regulation of bile acid production.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Cholic Acid; DNA-Binding Proteins; Feedback; Homeostasis; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Nicotinic Acids; Nuclear Proteins; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Steroid; Retinoid X Receptors; RNA, Messenger; Stem Cells; Tetrahydronaphthalenes; Transcription Factors | 2002 |
The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor.
Topics: Carrier Proteins; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Gene Expression Regulation; Humans; Hydroxysteroid Dehydrogenases; Hypolipidemic Agents; Inhibitory Concentration 50; Isoxazoles; Ligands; Liver; Mediator Complex Subunit 1; Membrane Glycoproteins; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Pregnadienes; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Receptors, Thyroid Hormone; Repressor Proteins; Transcription Factors | 2002 |
Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
Topics: Animals; Base Sequence; Bile Acids and Salts; Cells, Cultured; Chenodeoxycholic Acid; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Promoter Regions, Genetic; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; RNA, Messenger; Species Specificity; Taurocholic Acid; Transcription Factors; Tumor Cells, Cultured | 2003 |
Human kininogen gene is transactivated by the farnesoid X receptor.
Topics: Binding Sites; Blotting, Northern; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; DNA; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Kininogens; Liver Neoplasms; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Repetitive Sequences, Nucleic Acid; Retinoid X Receptors; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2003 |
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.
Topics: Animals; Anthracenes; Bile Acids and Salts; Cell Line; Cells, Cultured; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Enzyme Repression; Fibroblast Growth Factors; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Response Elements; Signal Transduction; Transcription Factors; Transfection | 2003 |
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.
Topics: Animals; Apolipoprotein C-III; Apolipoproteins C; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Bile Acids and Salts; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Cholestyramine Resin; Dimerization; DNA-Binding Proteins; Gene Expression Regulation; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Phosphoproteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; RNA, Messenger; Transcription Factors; Triglycerides | 2003 |
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Carrier Proteins; Cholestasis; Cytoprotection; DNA-Binding Proteins; Isocyanates; Isoxazoles; Male; Membrane Transport Proteins; Naphthalenes; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Steroid 12-alpha-Hydroxylase; Symporters; Taurine; Transcription Factors; Ursodeoxycholic Acid | 2003 |
The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
Topics: Animals; Bile Acids and Salts; Cell Line, Tumor; Chenodeoxycholic Acid; DNA-Binding Proteins; Hepatocytes; Humans; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; RNA, Small Interfering; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Up-Regulation | 2004 |
Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Bile Acids and Salts; Binding Sites; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA-Binding Proteins; Female; Humans; In Vitro Techniques; Isoxazoles; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors | 2004 |
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.
Topics: Animals; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Cholesterol; DNA Primers; DNA-Binding Proteins; Gallbladder; Gallstones; Gene Expression; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Mice; Mice, Knockout; Phospholipids; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2004 |
Regulation of carbohydrate metabolism by the farnesoid X receptor.
Topics: Animals; Bile Acids and Salts; Carbohydrate Metabolism; Carbohydrates; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Glucocorticoids; Glucose; Hepatocytes; Humans; Immunoblotting; Isoxazoles; Lipid Metabolism; Lipoproteins; Liver; Mice; Mice, Inbred C57BL; Models, Biological; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; PPAR alpha; Pregnenediones; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors | 2005 |
Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates.
Topics: Arachidonic Acid; Isoxazoles; Models, Molecular; Molecular Structure; Oleic Acid; Organic Anion Transporters, Sodium-Independent; Quantitative Structure-Activity Relationship; Steroids; Substrate Specificity | 2005 |
Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes.
Topics: Animals; Cells, Cultured; Cholic Acids; DNA-Binding Proteins; Gene Expression; Hepatocytes; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Response Elements; Signal Transduction; Transcription Factors; Tumor Necrosis Factor-alpha | 2005 |
VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium.
Topics: Base Sequence; Cells, Cultured; Chenodeoxycholic Acid; DNA Primers; DNA-Binding Proteins; Epithelial Cells; Gallbladder; Gene Expression Regulation; Humans; Isoxazoles; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2005 |
FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
Topics: Adrenal Glands; Animals; Base Sequence; Bile Acids and Salts; Cell Line; Conserved Sequence; DNA-Binding Proteins; Female; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Humans; Intestinal Mucosa; Isoxazoles; Kidney; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transfection | 2006 |
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholesterol, Dietary; Cholic Acid; DNA-Binding Proteins; Feces; Female; Gene Expression; Homeostasis; Hydroxymethylglutaryl CoA Reductases; Isoxazoles; Lipids; Lipoproteins; Liver; Liver X Receptors; Male; Mice; Mice, Knockout; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Steroid 12-alpha-Hydroxylase; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transcription Factors | 2006 |
The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
Topics: Base Sequence; Bile Acids and Salts; Cell Line, Tumor; Chenodeoxycholic Acid; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Humans; Ileum; Isoxazoles; Membrane Transport Proteins; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Retinoid X Receptor alpha; Transcription Factors | 2006 |
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.
Topics: Administration, Oral; Animals; Anthracenes; Aryldialkylphosphatase; Bile Acids and Salts; Cell Line, Tumor; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Cholesterol, Dietary; Cholic Acid; Dietary Fats; DNA-Binding Proteins; Enzyme Inhibitors; Female; Fibroblast Growth Factors; Gene Expression; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phospholipid Transfer Proteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2006 |
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Blotting, Northern; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Etoposide; Gluconeogenesis; Glucose; Glycogen; Hepatocytes; Hyperglycemia; Hyperlipidemias; Insulin; Insulin Resistance; Isoxazoles; Lipids; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Statistical; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Triglycerides | 2006 |
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; DNA-Binding Proteins; Fatty Acids, Nonesterified; Female; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Homeostasis; Homozygote; Insulin; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; Muscle, Skeletal; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors | 2006 |
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Topics: Animals; Bile Acids and Salts; Cholestanetriol 26-Monooxygenase; DNA-Binding Proteins; Gene Expression Regulation; Humans; Intestinal Mucosa; Intestine, Small; Isoxazoles; Male; Mice; Mice, Knockout; Microscopy, Electron; Receptors, Cytoplasmic and Nuclear; Steroid Hydroxylases; Transcription Factors | 2006 |
Pregnane X receptor is a target of farnesoid X receptor.
Topics: Animals; Bile Acids and Salts; Binding Sites; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Humans; Isoxazoles; Mice; Mice, Transgenic; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors; Transcriptional Activation; Xenobiotics | 2006 |
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression.
Topics: Apoptosis; Aromatase; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; DNA-Binding Proteins; Humans; Hydroxysteroid Dehydrogenases; Isoxazoles; Ligands; Multidrug Resistance-Associated Protein 2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors | 2006 |
Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation.
Topics: Amidohydrolases; Animals; Arginine; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Isoxazoles; Liver; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2006 |
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Design; Humans; Indicators and Reagents; Isoxazoles; Ligands; Magnetic Resonance Spectroscopy; Plasmids; Progesterone; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcriptional Activation; Transfection | 2007 |
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Topics: Adrenal Glands; Animals; Bile Acids and Salts; Chenodeoxycholic Acid; DNA-Binding Proteins; Genes, Reporter; Ileum; Isoxazoles; Kidney; Ligands; Liver; Luciferases; Mice; Mice, Transgenic; Models, Animal; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors | 2007 |
Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.
Topics: Animals; Bile Acids and Salts; Cell Nucleus; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Feedback, Physiological; Gene Expression Regulation; Histone Acetyltransferases; Histone Deacetylases; Humans; Isoxazoles; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Nuclear Receptor Co-Repressor 2; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Messenger; RNA, Small Interfering; Transcription Factors; Transcription, Genetic | 2007 |
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; DNA-Binding Proteins; Fibroblast Growth Factors; Isoxazoles; Liver; Malabsorption Syndromes; Mice; Mice, Inbred Strains; Models, Animal; Organic Anion Transporters, Sodium-Dependent; Receptors, Cytoplasmic and Nuclear; Symporters; Transcription Factors | 2007 |
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Chenodeoxycholic Acid; DNA-Binding Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Isoxazoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2008 |
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.
Topics: Animals; Anti-Inflammatory Agents; Becaplermin; Cell Line; Cell Movement; Cell Survival; Cells, Cultured; Chenodeoxycholic Acid; Cyclooxygenase 2; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Inflammation; Interleukin-1beta; Isoxazoles; Ligands; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Nitric Oxide Synthase Type II; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; RNA, Small Interfering; Transcription Factors; Transcription, Genetic; Transfection | 2007 |
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes.
Topics: Chenodeoxycholic Acid; DNA-Binding Proteins; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoxazoles; Pravastatin; Proprotein Convertase 9; Proprotein Convertases; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; RNA, Messenger; Serine Endopeptidases; Transcription Factors; Transcription, Genetic | 2008 |
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.
Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cell Line; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diabetes Mellitus, Type 1; DNA-Binding Proteins; Enzyme Induction; Fasting; Heat-Shock Proteins; Homeostasis; Humans; Isoxazoles; Liver; Male; Mice; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Promoter Regions, Genetic; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA-Binding Proteins; Trans-Activators; Transcription Factors; Transcriptional Activation | 2008 |
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.
Topics: Animals; Apoptosis; Cell Communication; Cell Line; Chenodeoxycholic Acid; DNA-Binding Proteins; Hepatocytes; Humans; Isoxazoles; Ligands; Liver; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2008 |
Upregulation of decorin by FXR in vascular smooth muscle cells.
Topics: Cells, Cultured; Decorin; DNA-Binding Proteins; Extracellular Matrix Proteins; Gene Expression Regulation; Humans; Isoxazoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proteoglycans; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; RNA, Messenger; Sequence Analysis, DNA; Transcription Factors; Up-Regulation | 2008 |
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Topics: Administration, Oral; Animals; Carboxylic Acids; Cholestasis; Crystallography, X-Ray; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gastric Mucosa; Haplorhini; Isoxazoles; Mice; Molecular Conformation; Molecular Structure; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Stomach; Structure-Activity Relationship; Transcription Factors | 2008 |
Chronic stimulation of farnesoid X receptor impairs nitric oxide sensitivity of vascular smooth muscle.
Topics: Animals; Cyclic GMP; DNA-Binding Proteins; Endothelium, Vascular; Glyceraldehyde-3-Phosphate Dehydrogenases; Iloprost; Isoxazoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Organ Culture Techniques; Rabbits; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Vasodilator Agents | 2009 |
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Topics: Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Fibroblast Growth Factors; Gene Expression; Hepatocytes; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors | 2009 |
Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.
Topics: Adenosine Triphosphatases; Bile Acids and Salts; Cell Line, Tumor; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hepatoblastoma; Humans; Isoxazoles; Liver Neoplasms; Phosphorylation; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Small Interfering; Transcription Factors; Transfection | 2009 |
Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.
Topics: Binding Sites; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Humans; Hydrogen Bonding; Isoxazoles; Ligands; Models, Chemical; Protein Binding; Receptors, Cytoplasmic and Nuclear; Serine; Tyrosine | 2009 |
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Branched DNA Signal Amplification Assay; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fluorescent Antibody Technique; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA | 2009 |
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
Topics: Animals; Crystallography, X-Ray; Fluorescence Resonance Energy Transfer; Isoxazoles; Rats; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2009 |
Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.
Topics: Anticholesteremic Agents; Apolipoprotein A-I; Butyrates; Caco-2 Cells; Cell Differentiation; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Intestine, Small; Isoxazoles; Models, Biological; Peroxisome Proliferators; Phenylurea Compounds; Pyrimidines; Receptors, Cytoplasmic and Nuclear | 2009 |
FXR agonist activity of conformationally constrained analogs of GW 4064.
Topics: Animals; Binding Sites; Computer Simulation; Crystallography, X-Ray; Humans; Isoxazoles; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Thiophenes | 2009 |
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Cationic Amino Acid Transporter 1; Cell Line; Cells, Cultured; Haplorhini; Humans; Isoxazoles; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Receptors, Cytoplasmic and Nuclear | 2009 |
Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice.
Topics: Animals; Bile; Bile Acids and Salts; Caco-2 Cells; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Enterohepatic Circulation; Fatty Acids, Essential; Feedback, Physiological; Fibroblast Growth Factors; Humans; Intestinal Absorption; Intestine, Small; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2009 |
Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes).
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental; Isoxazoles; Liver; Male; Oryzias; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Yolk Sac | 2010 |
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.
Topics: Animals; Aromatase; Cathartics; Chenodeoxycholic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Hep G2 Cells; Humans; Isoxazoles; Leydig Cell Tumor; Leydig Cells; Male; Mice; Neoplasm Proteins; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Response Elements; Steroidogenic Factor 1 | 2010 |
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.
Topics: 3' Untranslated Regions; Animals; Gene Expression Regulation; Hep G2 Cells; Humans; Isoxazoles; Liver; Mice; Mice, Obese; MicroRNAs; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Sirtuin 1; Tumor Suppressor Protein p53 | 2010 |
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Topics: 3' Untranslated Regions; Base Sequence; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Fibroblast Growth Factors; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA Processing, Post-Transcriptional; Transcription, Genetic | 2010 |
The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.
Topics: Animals; Blotting, Western; Cells, Cultured; Humans; In Vitro Techniques; Insulin-Secreting Cells; Islets of Langerhans; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity; Palmitic Acid; Rats; Receptors, Cytoplasmic and Nuclear | 2010 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Topics: Administration, Oral; Animals; Anti-Obesity Agents; Binding Sites; Cholesterol; Computer Simulation; Isoxazoles; Mice; Mice, Obese; Receptors, Cytoplasmic and Nuclear; Triglycerides | 2010 |
Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Bile; Cholesterol; Cholic Acids; Gene Knockout Techniques; Intestinal Absorption; Isoxazoles; Liver; Mice; Micelles; Receptors, Cytoplasmic and Nuclear | 2010 |
Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand.
Topics: Animals; Blotting, Western; Cell Shape; Cell Transdifferentiation; Cells, Cultured; Endothelin-1; Gene Expression Regulation; Hepatic Stellate Cells; Isoxazoles; Male; Microfilament Proteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Signal Transduction | 2010 |
Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Hepatocytes; Homeostasis; Humans; Isoxazoles; Lipoproteins; Liver; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear | 2011 |
Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α.
Topics: Animals; Binding Sites; Cell Line; ERRalpha Estrogen-Related Receptor; Genes, Reporter; Humans; Isoxazoles; Liver; Luciferases; Mice; Mice, Knockout; Muscle, Skeletal; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Promoter Regions, Genetic; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Thermodynamics; Trans-Activators; Transcription Factors; Transcription, Genetic | 2011 |
Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chenodeoxycholic Acid; Chromatin Immunoprecipitation; Down-Regulation; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 3; NF-kappa B; Promoter Regions, Genetic; Receptor, ErbB-2; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tamoxifen | 2011 |
Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β.
Topics: AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Protein-beta; Chenodeoxycholic Acid; Hep G2 Cells; Hepatocytes; Humans; Immunoblotting; Inactivation, Metabolic; Isoxazoles; Ligands; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Transfection; Xenobiotics | 2011 |
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.
Topics: 3T3-L1 Cells; Animals; Bile Acids and Salts; Body Weight; Diabetes Mellitus; Dietary Fats; Energy Metabolism; Isoxazoles; Metabolic Syndrome; Mice; Obesity; Receptors, Cytoplasmic and Nuclear | 2011 |
A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys.
Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Drug Evaluation, Preclinical; Isoxazoles; Macaca fascicularis; Mesocricetus; Receptors, Cytoplasmic and Nuclear; Solubility; Tandem Mass Spectrometry | 2011 |
Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
Topics: Amino Acid Sequence; Animals; Cell Line; Humans; Isoxazoles; Molecular Conformation; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear; Stilbenes | 2011 |
FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Bile Acids and Salts; Blood Glucose; Cardiovascular Diseases; Chenodeoxycholic Acid; Dyslipidemias; Fibrosis; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Isoxazoles; Lipid Metabolism; Liver; Myocardium; Obesity; PPAR alpha; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Risk Factors; RNA, Messenger; Triglycerides | 2013 |
Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.
Topics: Animals; Bile Acids and Salts; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Feces; Gastrointestinal Agents; Gene Expression Regulation; Glucagon-Like Peptide 1; Hypoglycemic Agents; Intestinal Absorption; Intestine, Small; Isoxazoles; Liver; Male; Organic Anion Transporters, Sodium-Dependent; Random Allocation; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Symporters; Thiazepines | 2012 |
Inhibitory effects of bile acids and synthetic farnesoid X receptor agonists on rotavirus replication.
Topics: Animals; Blotting, Western; Caco-2 Cells; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Female; Gastrointestinal Agents; Humans; Isoxazoles; Liver Neoplasms; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Rotavirus; Rotavirus Infections; Triglycerides; Tumor Cells, Cultured; Virus Replication | 2011 |
Impact of bile acids on the growth of human cholangiocarcinoma via FXR.
Topics: Animals; Bile Acids and Salts; Cell Line; Cholangiocarcinoma; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Mice; Mice, Nude; Neoplasms, Experimental; Receptors, Cytoplasmic and Nuclear | 2011 |
A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.
Topics: Animals; Catechin; Cells, Cultured; Chenodeoxycholic Acid; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Coactivator 2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tea | 2012 |
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.
Topics: Animals; Bile Acids and Salts; Diabetes Mellitus, Type 2; Dyslipidemias; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucose; Hydroxylation; Insulin; Isoxazoles; Lipid Metabolism; Liver; Male; Metabolome; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Steroid 12-alpha-Hydroxylase; Triglycerides | 2012 |
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Chenodeoxycholic Acid; Cyclosporine; Cytochromes c; Enzyme Inhibitors; Isoxazoles; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pregnenediones; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering | 2013 |
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2.
Topics: Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cell Line; Cholestasis, Intrahepatic; Dogs; Drug Evaluation, Preclinical; Endoplasmic Reticulum; Gene Expression; Isoxazoles; Mutation; Phenylbutyrates; Structure-Activity Relationship | 2012 |
Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.
Topics: Animals; Base Sequence; Cells, Cultured; Cholesterol; Diet, High-Fat; Female; Hep G2 Cells; Hepatocytes; Humans; Introns; Isoxazoles; Lipoproteins, HDL; Liver; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Scavenger Receptors, Class B | 2012 |
The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.
Topics: Atherosclerosis; Cell Line; Cell Separation; gag Gene Products, Human Immunodeficiency Virus; Gene Expression Regulation; GTP-Binding Proteins; HIV Antigens; HIV Infections; HIV-1; Humans; Inflammation; Isoxazoles; Janus Kinases; Lipid Metabolism; Lipopolysaccharide Receptors; Macrophages; Monocytes; Neoplasm Proteins; Neutralization Tests; Phenotype; Phosphorylation; PPAR gamma; Receptors for Activated C Kinase; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; STAT1 Transcription Factor; Thiazolidinediones; Vaccination; Vidarabine | 2012 |
Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand.
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Humans; Isoxazoles; Liver Neoplasms; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Retinoids | 2012 |
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cell Line; Dogs; Dose-Response Relationship, Drug; Humans; Isoxazoles; Mutation; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2012 |
FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Apolipoproteins A; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Female; Glucocorticoids; Isoxazoles; Lipid Metabolism; Lipids; Liver; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Phosphoenolpyruvate Carboxykinase (ATP); Progesterone Reductase; Receptor, Melanocortin, Type 2; Receptors, Cytoplasmic and Nuclear; Scavenger Receptors, Class B; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase; Tryptophan Oxygenase | 2012 |
Activation of farnesoid X receptor increases the expression of cytokine inducible SH2-containing protein in HepG2 cells.
Topics: Animals; Chenodeoxycholic Acid; Cytokines; Hep G2 Cells; Hepatocytes; Humans; Interleukin-6; Isoxazoles; Janus Kinase 2; Liver; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Biosynthesis; Receptors, Cytoplasmic and Nuclear; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2012 |
FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Humans; Isoxazoles; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasm Metastasis; Protein Binding; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Burden; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2012 |
Unbinding pathways of GW4064 from human farnesoid X receptor as revealed by molecular dynamics simulations.
Topics: Algorithms; Crystallography, X-Ray; Humans; Isoxazoles; Kinetics; Molecular Dynamics Simulation; Protein Structure, Secondary; Receptors, Cytoplasmic and Nuclear; Thermodynamics | 2012 |
Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Epithelial Cells; ErbB Receptors; Gene Expression; Gene Knockdown Techniques; Humans; Intestinal Mucosa; Isoxazoles; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pregnenediones; Receptors, Cytoplasmic and Nuclear; RNA Interference; Signal Transduction; src-Family Kinases; Transplantation, Heterologous | 2012 |
Inhibition of Leydig tumor growth by farnesoid X receptor activation: the in vitro and in vivo basis for a novel therapeutic strategy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aromatase; Cell Proliferation; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Isoxazoles; Leydig Cell Tumor; Male; Mice; Mice, Nude; NF-kappa B; p21-Activated Kinases; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Testicular Neoplasms; Transcriptional Activation; Tumor Suppressor Protein p53; Up-Regulation; Xenograft Model Antitumor Assays | 2013 |
Dietary regulation of mouse intestinal P450 expression and drug metabolism.
Topics: Animal Feed; Animals; Bile Acids and Salts; Biotransformation; Cytochrome P-450 Enzyme System; Diet; Female; Hydroxylation; Intestines; Isoenzymes; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes, Liver; Midazolam; NADPH-Ferrihemoprotein Reductase; Receptors, Cytoplasmic and Nuclear; Substrate Specificity | 2013 |
Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance.
Topics: Animals; CD36 Antigens; Cell Line; Diet, High-Fat; Fatty Liver; Gene Expression Regulation; Isoxazoles; Lipid Metabolism; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Weight Gain | 2013 |
Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic steatohepatitis.
Topics: Animals; Cells, Cultured; Chemokines; Disease Progression; Down-Regulation; Fatty Liver; Gene Expression Regulation; HEK293 Cells; Hep G2 Cells; Humans; Intercellular Signaling Peptides and Proteins; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear | 2013 |
MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.
Topics: 3' Untranslated Regions; Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cholesterol, HDL; Gene Expression Regulation; HEK293 Cells; Hepatocytes; Humans; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Quinolines; Receptors, Cytoplasmic and Nuclear; Response Elements; RNA Interference; Time Factors; Transfection | 2013 |
Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Survival; Cells, Cultured; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Profiling; Hepatocytes; Humans; Isoxazoles; Liver Neoplasms; Luciferases; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic; Transcriptional Activation | 2013 |
Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.
Topics: Biological Assay; Drug Discovery; Fluoresceins; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Gene Expression Regulation; Isoxazoles; Molecular Structure; Protein Binding; Receptors, Cytoplasmic and Nuclear | 2013 |
Nuclear receptors and microRNA-144 coordinately regulate cholesterol efflux.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cholesterol, HDL; Hepatocytes; Humans; Isoxazoles; Macrophages; Male; MicroRNAs; Quinolines; Receptors, Cytoplasmic and Nuclear | 2013 |
Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes.
Topics: Cells, Cultured; Chenodeoxycholic Acid; Diacylglycerol Kinase; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Glucose; Hep G2 Cells; Hepatocytes; Humans; Isoenzymes; Isoxazoles; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Mutation; Phosphatidic Acids; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Regulation of human class I alcohol dehydrogenases by bile acids.
Topics: Alcohol Dehydrogenase; Alcohols; Animals; Base Sequence; Chenodeoxycholic Acid; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; Ligands; Male; Mice; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; RNA, Messenger; Signal Transduction | 2013 |
Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.
Topics: Animals; Antidiarrheals; Blotting, Western; Caco-2 Cells; Cells, Cultured; Colon; Diarrhea; Electrodiagnosis; Humans; Intestinal Mucosa; Ion Transport; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers | 2014 |
Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition.
Topics: Bile Acids and Salts; Cells, Cultured; Glycine; Hepatocytes; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Kidney; Liver; Organ Specificity; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Taurine | 2013 |
Transcriptional activity and expression of liver X receptor in the ascidian Halocynthia roretzi.
Topics: Animals; Benzoates; Benzylamines; Cloning, Molecular; DNA, Complementary; Gene Expression Regulation; HEK293 Cells; Humans; Isoxazoles; Liver X Receptors; Orphan Nuclear Receptors; Phylogeny; RNA, Messenger; Urochordata | 2013 |
Target hopping as a useful tool for the identification of novel EphA2 protein-protein antagonists.
Topics: Binding Sites; Cell Line, Tumor; Drug Design; Ephrin-A1; Humans; Isoxazoles; Lithocholic Acid; Molecular Docking Simulation; Protein Binding; Protein Interaction Maps; Protein Structure, Tertiary; Receptor, EphA2; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2014 |
Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice.
Topics: Animals; Apolipoproteins; Chenodeoxycholic Acid; Gene Expression Regulation; Hep G2 Cells; Humans; Isoxazoles; Liver; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Up-Regulation | 2013 |
[Effects of farnesoid X receptor agonist on adiponectin and its receptors].
Topics: 3T3-L1 Cells; Adiponectin; Animals; Cell Differentiation; Hep G2 Cells; Humans; Isoxazoles; Mice; PPAR gamma; Receptors, Adiponectin; Receptors, Cytoplasmic and Nuclear | 2014 |
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors.
Topics: Active Transport, Cell Nucleus; Calcineurin; Calcium Signaling; Cell Survival; Cyclic AMP; Genes, Reporter; HEK293 Cells; Hep G2 Cells; Heterotrimeric GTP-Binding Proteins; Humans; Inhibitory Concentration 50; Isoxazoles; Luciferases; MCF-7 Cells; NFATC Transcription Factors; Phosphoinositide Phospholipase C; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Transcriptional Activation | 2014 |
Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP).
Topics: Animals; Arginine; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Capsaicin; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Interleukin-10; Isoxazoles; Male; Malondialdehyde; Nitric Oxide; Rats, Wistar; Reperfusion Injury; Stomach Diseases; Tumor Necrosis Factor-alpha | 2014 |
Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.
Topics: Amino Acid Sequence; Chenodeoxycholic Acid; Deuterium Exchange Measurement; Escherichia coli; Humans; Hypolipidemic Agents; Isoxazoles; Ligands; Mass Spectrometry; Molecular Docking Simulation; Molecular Sequence Data; Pregnenediones; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins | 2014 |
Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.
Topics: Bile Acids and Salts; CD36 Antigens; Chenodeoxycholic Acid; Endocytosis; Hep G2 Cells; Humans; Isoxazoles; Lipoproteins, HDL; Receptors, Cytoplasmic and Nuclear; Scavenger Receptors, Class B; Taurocholic Acid; Transferrin | 2014 |
FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Apoptosis; Cell Line; Disease Models, Animal; Down-Regulation; Female; Humans; Inflammation Mediators; Isoxazoles; Lipopolysaccharides; Liver; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Middle Aged; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear | 2014 |
Transcriptional regulation of autophagy by an FXR-CREB axis.
Topics: Animals; Autophagy; Cyclic AMP Response Element-Binding Protein; Fasting; Gene Expression Regulation; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Protein Binding; Receptors, Cytoplasmic and Nuclear | 2014 |
GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; Mice; PPAR gamma; Receptors, Adiponectin; Receptors, Cytoplasmic and Nuclear; Receptors, Leptin; RNA, Messenger; Signal Transduction; Time Factors; Up-Regulation | 2014 |
Effects of bile acids and the bile acid receptor FXR agonist on the respiratory rhythm in the in vitro brainstem medulla slice of neonatal Sprague-Dawley rats.
Topics: Animals; Bile Acids and Salts; Isoxazoles; Medulla Oblongata; Pregnenediones; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Respiratory Rate | 2014 |
Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS).
Topics: Animals; Apoptosis; Bile Acids and Salts; Blotting, Western; Cell Line; Chenodeoxycholic Acid; Common Bile Duct; Epithelial Cells; Gene Expression; Hepatopulmonary Syndrome; Isoxazoles; Male; Microscopy, Fluorescence; Pulmonary Alveoli; Pulmonary Surfactant-Associated Proteins; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2014 |
Glucocorticoids as modulators of expression and activity of Antithrombin (At): potential clinical relevance.
Topics: Aged; Antithrombins; Base Sequence; Cardiopulmonary Bypass; Cohort Studies; Female; Glucocorticoids; Hep G2 Cells; Humans; Isoxazoles; Ligands; Male; Middle Aged; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Retinoids; RNA-Binding Proteins; Treatment Outcome | 2015 |
Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.
Topics: Animals; Antioxidants; Base Sequence; Carcinogenesis; Enzyme Activation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Liver; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Oxidants; Phosphorylation; Promoter Regions, Genetic; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Superoxide Dismutase; Up-Regulation | 2015 |
Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.
Topics: Drug Evaluation, Preclinical; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Oxazolidinones; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2015 |
The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.
Topics: Animals; ATP Binding Cassette Transporter 1; Binding Sites; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Cholesterol; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Introns; Isoxazoles; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Promoter Regions, Genetic; Quinolines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sterol Regulatory Element Binding Protein 2; Transcription, Genetic; Transfection | 2015 |
Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Female; Genes, Reporter; HEK293 Cells; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Humans; Isoenzymes; Isoxazoles; Kruppel-Like Transcription Factors; Luciferases; Mice; Mice, Transgenic; Pregnancy; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcriptional Activation | 2015 |
Role of FXR in β-cells of lean and obese mice.
Topics: Animals; Chenodeoxycholic Acid; Female; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoxazoles; Male; Mice; Mice, Knockout; Mice, Obese; Obesity; Receptors, Cytoplasmic and Nuclear; Taurochenodeoxycholic Acid | 2015 |
GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.
Topics: Cell Line; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2015 |
Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HEK293 Cells; Hepatocytes; Humans; Isoxazoles; Mice; Mice, Knockout; Mice, Transgenic; Receptors, Cytoplasmic and Nuclear; Transcription, Genetic | 2015 |
Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.
Topics: Cell Survival; Crystallography, X-Ray; Gene Expression; HeLa Cells; Hep G2 Cells; Humans; Hydrolysis; Isoxazoles; Ligands; Molecular Docking Simulation; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Transfection | 2015 |
Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells.
Topics: Apolipoproteins; Apolipoproteins M; Bile Acids and Salts; Chromatin Immunoprecipitation; Gene Expression Regulation; Gene Silencing; Hep G2 Cells; Humans; Isoxazoles; Lipocalins; Liver; Plasmids; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transfection | 2015 |
Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes.
Topics: Blotting, Western; Cell Hypoxia; Chenodeoxycholic Acid; DNA Primers; Gene Expression Regulation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoxazoles; Leupeptins; Pregnenediones; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Benzamides; Crystallography, X-Ray; Gene Expression Regulation; Glucose-6-Phosphatase; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; Male; Mice; Mice, Knockout; Molecular Docking Simulation; Mutation; Phosphoenolpyruvate Carboxykinase (ATP); Primary Cell Culture; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, Leptin; Recombinant Proteins; Retinoid X Receptors; Signal Transduction | 2015 |
Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Bile Acids and Salts; Cell Line, Tumor; DNA; Gene Expression Profiling; Gene Expression Regulation; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Isoxazoles; Kupffer Cells; Liver; Macrophages; Macrophages, Peritoneal; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Oleanolic Acid; Receptors, G-Protein-Coupled | 2015 |
Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Gene Knockdown Techniques; Hep G2 Cells; Humans; Isoxazoles; Liver; Male; Mice, Inbred BALB C; Phenanthrenes; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering | 2015 |
Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells.
Topics: CDX2 Transcription Factor; Cell Line; Cell Proliferation; Deoxycholic Acid; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation; Homeodomain Proteins; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Metaplasia; Mucin-2; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2015 |
FXR induces SOCS3 and suppresses hepatocellular carcinoma.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Immunohistochemistry; Isoxazoles; Liver Neoplasms; Mice; Mice, Nude; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transfection; Xenograft Model Antitumor Assays | 2015 |
Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy.
Topics: Animals; Cell Line; Cell Proliferation; Cytokines; Diabetic Nephropathies; Disease Models, Animal; Gene Expression Regulation; Humans; Isoxazoles; Male; Mesangial Cells; Mice; Nicotinamide Phosphoribosyltransferase; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Transcription, Genetic | 2016 |
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho.
Topics: Animals; Fibroblast Growth Factors; Hepatocytes; Intestinal Mucosa; Intestines; Isoxazoles; Klotho Proteins; Liver; Membrane Proteins; Mice; Mice, Knockout; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2016 |
Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential.
Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chenodeoxycholic Acid; Female; Humans; Isoxazoles; Receptors, Cytoplasmic and Nuclear | 2016 |
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Topics: Adolescent; Adult; Aged; Animals; Ceramides; Cholic Acids; Diet, High-Fat; Fatty Liver; Female; Glycine; Humans; Ileum; Insulin Resistance; Intestinal Mucosa; Isoxazoles; Liver; Male; Mice; Middle Aged; Obesity; Receptors, Cytoplasmic and Nuclear; Young Adult | 2015 |
Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glycolysis; Hep G2 Cells; Humans; Isoxazoles; Liver Regeneration; Metabolome; Metabolomics; Mice; Mice, Knockout; Models, Biological; Protein Kinases; Receptors, Cytoplasmic and Nuclear | 2016 |
Bile acid-FXRα pathways regulate male sexual maturation in mice.
Topics: Animals; Bile Acids and Salts; Cell Line; Cholic Acid; Fertility; Isoxazoles; Leydig Cells; Male; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Receptors, Cytoplasmic and Nuclear; RNA Interference; Sexual Maturation; Signal Transduction; Testis; Testosterone | 2016 |
Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cancer-Associated Fibroblasts; Carcinogenesis; Cell Communication; Cell Line, Tumor; Culture Media, Conditioned; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Leptin; MCF-7 Cells; Mice, Nude; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Xenograft Model Antitumor Assays | 2016 |
Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis; Cytokines; Cytoprotection; Hep G2 Cells; Hepatocytes; Hormesis; Humans; Isoxazoles; Liver Diseases; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Time Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vitamin K 3 | 2016 |
FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-X Protein; Biliary Tract; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chenodeoxycholic Acid; Cholangiocarcinoma; Cisplatin; Down-Regulation; Drug Synergism; Frataxin; Gallbladder Neoplasms; Humans; Iron-Binding Proteins; Isoxazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; STAT3 Transcription Factor | 2016 |
Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression.
Topics: Animals; Chenodeoxycholic Acid; Diet, High-Fat; Gene Expression Regulation; Group X Phospholipases A2; Hep G2 Cells; Humans; Hyperlipidemias; Isoxazoles; Ligands; Lipid Metabolism; Lipoproteins, VLDL; Male; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Triglycerides | 2016 |
Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064.
Topics: Animals; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Female; Ileum; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy Outcome; Receptors, Cytoplasmic and Nuclear | 2016 |
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.
Topics: Animals; Blood Platelets; Calcium Signaling; Chenodeoxycholic Acid; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinogen; Genotype; Hemostasis; Humans; Isoxazoles; Ligands; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cytoplasmic and Nuclear; Thrombosis; Time Factors | 2016 |
Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis.
Topics: Adaptor Proteins, Signal Transducing; Adipogenesis; Animals; Apoptosis; Cell Survival; Fatty Liver; Hepatectomy; Hepatocytes; Isoxazoles; Liver; Liver X Receptors; Mice; NF-E2-Related Factor 2; Receptors, Cytoplasmic and Nuclear; Sequestosome-1 Protein; Signal Transduction; Up-Regulation | 2017 |
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection.
Topics: Animals; Bile Acids and Salts; CD8-Positive T-Lymphocytes; Cells, Cultured; Hepatocytes; Interferon Type I; Isoxazoles; Kupffer Cells; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Transcriptional Activation; Up-Regulation; Virus Replication | 2017 |
An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.
Topics: Acetyl Coenzyme A; Amidohydrolases; Animals; Body Weight; Caffeic Acids; Ceramides; Diet, High-Fat; Gastrointestinal Microbiome; Gluconeogenesis; Ileum; Insulin; Intestinal Mucosa; Intestines; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Phenylethyl Alcohol; Pyruvate Carboxylase; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Taurocholic Acid | 2017 |
Transcriptional Regulation of Human UDP-Glucuronosyltransferase 2B10 by Farnesoid X Receptor in Human Hepatoma HepG2 Cells.
Topics: Binding Sites; Blotting, Western; Chenodeoxycholic Acid; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Glucuronosyltransferase; Hep G2 Cells; Humans; Isoxazoles; Models, Biological; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors | 2017 |
Activation of FXR pathway does not alter glial cell function.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cerebellum; Cytokines; Dose-Response Relationship, Drug; In Vitro Techniques; Isoxazoles; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Protein; Nerve Tissue Proteins; Nitric Oxide; Nogo Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Receptor, Platelet-Derived Growth Factor alpha; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tumor Necrosis Factor-alpha | 2017 |
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.
Topics: Animals; Bile Acids and Salts; Calcium; Caspase 1; Cholestasis; Humans; Inflammasomes; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Models, Biological; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Binding; RAW 264.7 Cells; Receptors, Cytoplasmic and Nuclear; Sepsis | 2017 |
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.
Topics: Benzoates; Benzylamines; Blood Coagulation; Blood Platelets; Calcium Signaling; Cell-Derived Microparticles; Cyclophilins; Dose-Response Relationship, Drug; Fibrin; Fibrinogen; Humans; Isoxazoles; Ligands; Liver X Receptors; Membrane Potential, Mitochondrial; P-Selectin; Phosphatidylserines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear | 2017 |
Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice.
Topics: Animals; Colon; Ileum; Inflammatory Bowel Diseases; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Myeloid Differentiation Factor 88; Receptors, Cytoplasmic and Nuclear; Toll-Like Receptor 4 | 2017 |
A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism.
Topics: Alum Compounds; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Inflammasomes; Isoxazoles; Leukocytes, Mononuclear; Macrophages; Male; Mice; Mice, Inbred C57BL; Nigericin; NLR Family, Pyrin Domain-Containing 3 Protein; Peritonitis; Protein Multimerization; Receptors, Cytoplasmic and Nuclear; Sepsis; Ubiquitination | 2017 |
Farnesoid X receptor regulates SULT1E1 expression through inhibition of PGC1α binding to HNF4α.
Topics: Chenodeoxycholic Acid; Gene Expression Regulation; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Humans; Isoxazoles; Molecular Structure; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Cytoplasmic and Nuclear; Sulfotransferases | 2017 |
Effects of corilagin on alleviating cholestasis via farnesoid X receptor-associated pathways in vitro and in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cell Survival; Cells, Cultured; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cytochrome P450 Family 7; Dexamethasone; Down-Regulation; Glucosides; Glucuronosyltransferase; Humans; Hydrolyzable Tannins; Isoxazoles; Liver; Male; Organic Anion Transporters, Sodium-Dependent; Pregnenediones; Primary Cell Culture; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Steroid Hydroxylases; Sulfotransferases; Symporters; Up-Regulation; Ursodeoxycholic Acid | 2018 |
Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice.
Topics: Animals; Bile Acids and Salts; Diet, High-Fat; Gastrointestinal Microbiome; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2017 |
GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Inflammation; Isoxazoles; Lipopolysaccharides; Liver; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Receptors, Cytoplasmic and Nuclear; Toll-Like Receptor 4 | 2018 |
Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction.
Topics: 3T3-L1 Cells; Adiponectin; Animals; Apoptosis; Disease Models, Animal; Heart Ventricles; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Infarction; Myocytes, Cardiac; Organelle Biogenesis; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Stroke Volume; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells.
Topics: Bile Acids and Salts; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Liver; Liver Neoplasms; Receptors, Cytoplasmic and Nuclear; Transforming Growth Factor beta1 | 2018 |
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Cell Nucleus; Disease Models, Animal; Fibroblast Growth Factors; Healthy Volunteers; Hepatocytes; Humans; Intestinal Mucosa; Isoxazoles; Liver; Liver Cirrhosis, Biliary; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phosphorylation; Postprandial Period; Primary Cell Culture; Receptors, Cytoplasmic and Nuclear; Signal Transduction; src-Family Kinases; Tyrosine | 2018 |
Activation of Farnesoid X Receptor impairs the tumor-promoting function of breast cancer-associated fibroblasts.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Movement; Cell Transformation, Neoplastic; Coculture Techniques; Culture Media, Conditioned; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Hep G2 Cells; Humans; Isoxazoles; MCF-7 Cells; Middle Aged; Receptors, Cytoplasmic and Nuclear; Tumor Microenvironment | 2018 |
Structure-guided design and synthesis of isoflavone analogs of GW4064 with potent lipid accumulation inhibitory activities.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Drug Design; Hep G2 Cells; Humans; Isoflavones; Isoxazoles; Lipid Metabolism; Mice; Molecular Docking Simulation; Receptors, Cytoplasmic and Nuclear; Up-Regulation | 2018 |
Identification of FDA-approved drugs targeting the Farnesoid X Receptor.
Topics: Bile Acids and Salts; Biosensing Techniques; Cell Line; Drug Approval; Drug Repositioning; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Humans; Isoxazoles; Ivermectin; Ligands; Molecular Structure; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; United States; United States Food and Drug Administration | 2019 |
Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I.
Topics: Antiviral Agents; Cell Line; Down-Regulation; Drug Synergism; Hepacivirus; Humans; Isoxazoles; Mutation; Receptors, Cytoplasmic and Nuclear; RNA, Viral; Scavenger Receptors, Class B; Viral Proteins; Virus Internalization | 2019 |
Src-mediated crosstalk between FXR and YAP protects against renal fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Epithelial Cells; Fibrosis; Humans; Isoxazoles; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Proto-Oncogene Mas; Receptors, Cytoplasmic and Nuclear; Signal Transduction; src-Family Kinases; YAP-Signaling Proteins | 2019 |
System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.
Topics: Benzoates; Benzylamines; Butyrates; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Gene Expression; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Liver; Liver X Receptors; Orphan Nuclear Receptors; Phenylurea Compounds; PPAR alpha; Promoter Regions, Genetic; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Systems Analysis | 2019 |
OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids.
Topics: Antineoplastic Agents; Bile Acids and Salts; Biological Transport; Gene Expression Regulation; Gene Regulatory Networks; HeLa Cells; Hep G2 Cells; Humans; Isoxazoles; Organic Anion Transporters; Receptors, Cytoplasmic and Nuclear; Solute Carrier Organic Anion Transporter Family Member 1B3; Solute Carrier Proteins; Transcription Factors; Transcriptional Activation | 2019 |
Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5.
Topics: Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; HCT116 Cells; Humans; Isoxazoles; Proteomics; Receptors, Cytoplasmic and Nuclear; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sequestosome-1 Protein; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2019 |
Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts.
Topics: Animals; Cell Differentiation; Cell Survival; Chemistry Techniques, Synthetic; Fluoroimmunoassay; Genes, Reporter; Humans; Isoxazoles; Mesenchymal Stem Cells; Mice; Models, Molecular; Osteoblasts; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2019 |
Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclin G1; Humans; Isoxazoles; MicroRNAs; Osteoblasts; Osteosarcoma; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Up-Regulation | 2019 |
FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake.
Topics: Animals; Cell Line; Diabetes Mellitus, Type 2; Fasting; Forkhead Box Protein O1; Gluconeogenesis; Glucose; Humans; Isoxazoles; Male; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tacrolimus; Transplantation | 2019 |
Nerve growth factor induced farnesoid X receptor upregulation modulates autophagy flux and protects hepatocytes in cholestatic livers.
Topics: Animals; Autophagy; Cell Line, Tumor; Cholestasis; Cytoprotection; Hepatocytes; Humans; Isoxazoles; Liver; Male; Mice; Mice, Inbred ICR; Nerve Growth Factor; Protective Agents; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Signal Transduction; Transcriptional Activation | 2020 |
Bile acid treatment and FXR agonism lower postprandial lipemia in mice.
Topics: Animals; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Deoxycholic Acid; Exenatide; Gastric Emptying; Gene Expression Regulation; Hyperlipidemias; Insulin; Intestinal Mucosa; Intestines; Isoxazoles; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Taurocholic Acid | 2020 |
Increased levels of conjugated bile acids are associated with human bile reflux gastritis.
Topics: Animals; Bile Acids and Salts; Bile Reflux; Digestion; Disease Models, Animal; Gastric Juice; Gastritis; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lipids; Liver; Mice | 2020 |
Satiety induced by bile acids is mediated via vagal afferent pathways.
Topics: Afferent Pathways; Animals; Bile Acids and Salts; Deoxycholic Acid; Gene Expression Regulation; Humans; Isoxazoles; Leptin; Neurons; Nodose Ganglion; Rats; Receptor, Cholecystokinin A; Receptors, G-Protein-Coupled; Satiety Response; Vagus Nerve | 2020 |
Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.
Topics: Administration, Oral; Animals; Benzothiazoles; Drug Evaluation, Preclinical; Gene Expression Regulation; Hep G2 Cells; Humans; Isoxazoles; Lipids; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2021 |
Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile; Bile Acids and Salts; Cholestasis, Intrahepatic; Cucurbitaceae; Hepatocytes; Humans; Isoxazoles; Liver; Male; Molecular Docking Simulation; Phenols; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2021 |
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.
Topics: Animals; Blood Glucose; Cell Line; Cholic Acids; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Signal Transduction; Swine | 2021 |
Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model.
Topics: Adipose Tissue; Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Insulin Resistance; Isoxazoles; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear | 2021 |
GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis.
Topics: Animals; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Synergism; Humans; Inflammasomes; Isoxazoles; Mice, Inbred BALB C; Mice, Nude; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Oxaliplatin; Pyroptosis; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; STAT3 Transcription Factor | 2021 |
Development and in vitro Profiling of Dual FXR/LTA4H Modulators.
Topics: Chenodeoxycholic Acid; Drug Development; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Isoxazoles; Molecular Structure; Receptors, Cytoplasmic and Nuclear | 2021 |
Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
Topics: Animals; Bile Acids and Salts; Caco-2 Cells; Cell Line; Cell Line, Tumor; Cholestasis; Disease Models, Animal; Fibroblast Growth Factors; HEK293 Cells; Hep G2 Cells; Humans; Ileum; Isoxazoles; Ligands; Liver; Male; Mice; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Transcription Factors | 2021 |
Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages.
Topics: Aged; Animals; Bile Acids and Salts; Cell Nucleus; Chenodeoxycholic Acid; Female; Gene Expression Profiling; Humans; Interleukin-6; Isoxazoles; Leukocytes, Mononuclear; Macrophages; Male; Mice; Middle Aged; Promoter Regions, Genetic; RAW 264.7 Cells; Receptors, Cytoplasmic and Nuclear; Retroperitoneal Fibrosis; Signal Transduction | 2021 |
Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.
Topics: Animals; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Hyperbilirubinemia, Neonatal; Ileum; Isoxazoles; Liver; Mice; Rats, Gunn; Receptors, Cytoplasmic and Nuclear; Treatment Outcome; Ursodeoxycholic Acid | 2021 |
Bile acid-induced tissue factor activity in hepatocytes correlates with activation of farnesoid X receptor.
Topics: Apoptosis; Bile Acids and Salts; Cell Survival; Deoxycholic Acid; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; Liver; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thrombin; Thromboplastin | 2021 |
Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; Bile Acids and Salts; Cholestasis; Gene Expression; Gene Expression Regulation; Hepatocytes; Interleukin-1beta; Intestinal Diseases; Isoxazoles; Lipoproteins; Liver Diseases; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Parenteral Nutrition; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction | 2022 |
Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor.
Topics: Azetidines; Bile Acids and Salts; Binding Sites; Binding, Competitive; Calorimetry; Crystallization; Humans; Hydrogen Bonding; Isonicotinic Acids; Isoxazoles; Ligands; Molecular Docking Simulation; Molecular Structure; Protein Domains; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled | 2022 |
Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway.
Topics: Animals; Bone Remodeling; Bone Resorption; Female; Gene Expression Regulation; Isoxazoles; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; NFATC Transcription Factors; Osteoarthritis; Osteoclasts; Osteogenesis; RNA-Binding Proteins | 2022 |