isoxazoles has been researched along with glutamine in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 29 (45.31) | 18.7374 |
1990's | 22 (34.38) | 18.2507 |
2000's | 7 (10.94) | 29.6817 |
2010's | 6 (9.38) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Cooney, DA; Davis, RD; Driscoll, JS; Jayaram, HN; Milman, HA | 1 |
Holcenberg, JS | 1 |
Berger, AE; Bhuyan, BK; Blowers, CL; Kuentzel, SL; Neil, GL | 1 |
Keast, D; Vasquez, AR | 1 |
Doolabh, K; Mann, GE; Sastre, J; Sweiry, JH; Viña, J | 1 |
Hamm, LL; Herndon, J; Merli, C; Simon, EE | 1 |
Azoulay, M; Frappier, F; Vilmont, M | 1 |
Piesco, NP | 1 |
Davies, KP; Köhler, P | 1 |
Elliott, WL; Jayaram, HN; Lui, MS; Pillwein, K; Plowman, J; Reardon, MA; Weber, G | 1 |
Christopherson, RI; Lyons, SD; Sant, ME | 1 |
Prajda, N | 1 |
Cole, LA; Sahai, A; Tannen, RL | 1 |
Ardalan, B; Deas, M; Jayaram, HN; Johnson, RK | 1 |
Geary, TG; VandeWaa, EA; Williams, JF | 1 |
Dass, PD; Wu, MC | 1 |
Park, CH; Welbourne, TC | 1 |
Sastrasinh, M; Sastrasinh, S | 2 |
Bourke, E; Dass, PD; Delaney, V; Lawson, LR | 1 |
Dass, PD; Welbourne, TC | 1 |
Cao, L; Chance, WT; Fischer, JE; Foley-Nelson, T; Nelson, JL | 1 |
Cao, L; Chance, WT; Fischer, JE; Kim, MW; Nelson, JL | 1 |
Huber, KR; Roberts, J; Rosenfeld, H | 1 |
Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J | 1 |
Aoki, T; Eble, JN; Glover, JL; Sebolt, JS; Weber, G | 1 |
Elliott, WL; Weber, G | 1 |
Allen, LM; Corrigan, MV; Meinking, T | 1 |
Curthoys, NP; Shapiro, RA | 1 |
Anderson, PM; Casey, CA | 2 |
Arakawa, M; Ardalan, B; Cooney, DA; Jayaram, H; Villacorte, D | 1 |
Aoki, T; Burt, ME; Denton, JE; Faderan, MA; Lui, MS; Prajda, N; Reardon, MA; Sebolt, J; Weber, G; Zhen, YS | 1 |
Alonso, MT; Leyland-Jones, B; O'Dwyer, PJ | 1 |
Belt, RJ; Haas, CD; Hoogstraten, B; Joseph, U; Taylor, S | 1 |
Bower, SG; Tso, JY; Zalkin, H | 1 |
Roberts, J; Rosenfeld, H | 1 |
Lou, L; Nakamura, J; Straub, K; Wu, J | 1 |
Mu, X; Welbourne, TC | 1 |
Bloomer, WD; Damodaran, KM; Hughey, RP; Prezioso, JA; Wang, N | 1 |
Souba, WW | 1 |
Deshmukh, DR; Ghole, VS; Nelson, J; Qureshi, IA | 1 |
DeRuiter, J; Foster, LA; Geary, TG; Guderian, RH; Vande Waa, EA; Williams, JF | 1 |
Duguid, WP; Marliss, EB; Misra, M | 1 |
Li, X; Orwar, O; Revesjö, C; Sandberg, M | 1 |
Chevalier, D; Mu, X; Welbourne, TC | 1 |
Bertino, JR; Gritsman, H; Li, WW; Tong, WP; Waltham, MC | 1 |
Brown, T; Hidalgo, M; Kuhn, JG; MacGovren, JP; Rodriguez, G; Rowinsky, EK; Von Hoff, DD; Weiss, G | 1 |
Dringen, R; Hamprecht, B; Pfeiffer, B | 1 |
Brown, EL; Burke, BJ; Dragovich, PS; Ferre, RA; Ford, CE; Fuhrman, SA; Harr, JE; Hendrickson, TF; Kosa, MB; Lee, CA; Marakovits, JT; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Rejto, PA; Tuntland, T; Webber, SE; Worland, ST; Zhou, R | 1 |
Huang, Q; Lau, SS; Monks, TJ | 1 |
Fleck, C; Roskos, M; Schwertfeger, M | 1 |
Chittur, SV; Davisson, VJ; Klem, TJ; Shafer, CM | 1 |
Huang, LL; LaRossa, RA; McCluskey, MP; Reeve, MJ; Smulski, DR; Van Dyk, TK; Vollmer, AC | 1 |
Doi, H; Komatsu, H; Nishihira, T; Satomi, S | 1 |
Amrhein, N; Fitzpatrick, TB; Raschle, T | 1 |
Fukuyama, K; Hiratake, J; Irie, M; Kumagai, H; Okada, T; Suzuki, H; Wada, K; Yamada, C | 1 |
Ghosh, S; Maity, P; Mallick, P; Roy, S | 1 |
Dickinson, JA; Kew, JN; Livingstone, PD; Srinivasan, J; Wonnacott, S | 1 |
Balaram, H; Bhat, JY; Gupta, K; Sarma, SP; Singh, K; Venkatachala, R | 1 |
de Jong, J; Houdijk, AP; Vaessen, MJ; van Leeuwen, PA; Vermeulen, MA | 1 |
Brumby, AM; Humbert, PO; Manning, SA; Parisot, JP; Richardson, HE; Schlosser, T; Street, IP; Willoughby, LF | 1 |
Hwang, SY; Ki, MR; Yun, NR | 1 |
Abruzzo, G; Herath, K; Kahn, JN; Mann, P; Motyl, M; Singh, SB | 1 |
2 review(s) available for isoxazoles and glutamine
Article | Year |
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Glutamine and cancer.
Topics: Antimetabolites, Antineoplastic; Cell Division; Diazooxonorleucine; Glutamine; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lymphocytes; Muscles; Neoplasms; Parenteral Nutrition, Total; Randomized Controlled Trials as Topic | 1993 |
[Anti-cancer therapy with amino acid imbalance].
Topics: Amino Acids; Antimetabolites, Antineoplastic; Arginine; Asparagine; Glutamine; Humans; Isoxazoles; Methionine; Neoplasms; Valine | 2001 |
1 trial(s) available for isoxazoles and glutamine
Article | Year |
---|---|
A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies.
Topics: Adult; Aged; Amino Acids; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Electrolytes; Female; Glucose; Glutamine; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Parenteral Nutrition Solutions; Solutions; Thrombocytopenia; Treatment Outcome | 1998 |
61 other study(ies) available for isoxazoles and glutamine
Article | Year |
---|---|
Inhibitors of L-asparagine synthetase, in vitro.
Topics: Adenosine Triphosphate; Ammonia; Animals; Asparaginase; Aspartate-Ammonia Ligase; Aspartic Acid; Diphosphates; Drug Evaluation, Preclinical; Drug Resistance; Glutamine; Heparin; In Vitro Techniques; Isoxazoles; Leukemia, Experimental; Ligases; Malonates; Metals; Nitrosourea Compounds; Sulfhydryl Reagents | 1976 |
Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase.
Topics: Acinetobacter; Amino Acids; Animals; Asparaginase; Carcinoma, Ehrlich Tumor; Drug Synergism; Drug Therapy, Combination; Female; Glutaminase; Glutamine; Glycine; Isoxazoles; Lethal Dose 50; Leukemia L1210; Male; Mice; Oxazoles | 1979 |
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Glycine; Isoxazoles; Leukemia L1210; Leukemia P388; Macromolecular Substances; Male; Mice; Oxazoles; Sex Factors; Thymidine; Uridine; Valine | 1978 |
Inhibition in vitro of the replication of murine cytomegalovirus or reovirus type 3 by the glutamine analogue acivicin.
Topics: 3T3 Cells; Analysis of Variance; Animals; Cell Division; Cytomegalovirus; DNA, Viral; Glutamine; Isoxazoles; Mice; Reoviridae; RNA, Viral; Virus Replication | 1992 |
Significance of gamma-glutamyltranspeptidase in exocrine pancreatic amino acid transport.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Epithelium; gamma-Glutamyltransferase; Glutamine; Indicator Dilution Techniques; Isoxazoles; Male; Pancreas; Rats; Rats, Inbred Strains | 1991 |
Contribution of luminal ammoniagenesis to proximal tubule ammonia appearance in the rat.
Topics: Absorption; Ammonia; Animals; Antimetabolites; Glutamates; Glutamic Acid; Glutamine; Isoxazoles; Kidney Tubules; Osmolar Concentration; Perfusion; Rats; Rats, Inbred Strains | 1990 |
Metabolism of glutamine in erythrocytes infected with the human malaria parasite: Plasmodium falciparum.
Topics: Animals; Antimetabolites; Cells, Cultured; Diazooxonorleucine; Erythrocytes; gamma-Glutamyltransferase; Glutaminase; Glutamine; Humans; Isoxazoles; Plasmodium falciparum | 1990 |
The effect of acivicin, an inhibitor of gamma-glutamyl transpeptidase on mouse molar development in vitro.
Topics: Ameloblasts; Animals; Antimetabolites; Deoxyribonucleosides; gamma-Glutamyltransferase; Glutamine; Isoxazoles; Mice; Molar; Odontoblasts; Odontogenesis; Organ Culture Techniques; Ribonucleosides; Tooth Germ | 1990 |
The role of amino acids in the energy generating pathways of Litomosoides carinii.
Topics: Acetates; Alanine; Ammonia; Animals; Antimetabolites; Carbon Dioxide; Energy Metabolism; Female; Filarioidea; Glucose; Glutamine; Isoxazoles; Lactates; Lactic Acid; Rats | 1990 |
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbamates; Cattle; Cysteine; Drug Screening Assays, Antitumor; Glutamates; Glutamine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Rats | 1990 |
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Cell Line; Chromatography, High Pressure Liquid; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isoxazoles; Leukemia L1210; Ligases; Mice; Nucleotides; Oxazoles; Spectrophotometry, Ultraviolet | 1990 |
Enzyme targets of antiglutamine agents in cancer chemotherapy.
Topics: Animals; Anthranilate Synthase; Antibiotics, Antineoplastic; Azaserine; Drug Synergism; Glutamine; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nitrogenous Group Transferases; Oxazoles; Phosphoribosyl Pyrophosphate; Rats; Ribonucleotides; Transferases | 1985 |
Pathways and regulation of ammoniagenesis by the LLC-PK1 cells in culture.
Topics: Alanine; Aminooxyacetic Acid; Ammonia; Animals; Antimetabolites; Cell Line; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Isoxazoles; Ketoglutaric Acids; Kidney; Kinetics; Mitochondria; Models, Biological | 1989 |
Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Drug Resistance; Genetic Variation; Glutamine; Isoxazoles; Kinetics; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Oxazoles; Phosphoribosyl Pyrophosphate | 1985 |
Effects of intermediary metabolites and electron transport inhibitors on action of chloroquine on Brugia pahangi and Onchocerca volvulus.
Topics: Amino Acids, Diamino; Animals; Antimycin A; Brugia; Cell Movement; Chloroquine; Citric Acid Cycle; Drug Interactions; Electron Transport; Gerbillinae; Glutamine; Isoxazoles; Onchocerca; Rotenone | 1989 |
Uptake and metabolism of glutamine in cultured kidney cells.
Topics: Animals; Biological Transport, Active; Cells, Cultured; gamma-Glutamyltransferase; Glutamine; Hippurates; Isoxazoles; Kidney; Kinetics; Rats | 1985 |
Fate of intraluminal glutamine in the perfused renal tubule.
Topics: Absorption; Animals; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutamine; Hydrolysis; In Vitro Techniques; Isoxazoles; Kidney Tubules, Proximal; Microvilli; Perfusion; Rabbits | 1986 |
Effect of acivicin on glutamine transport by rat renal brush border membrane vesicles.
Topics: Amino Acids; Animals; Biological Transport; gamma-Glutamyltransferase; Glucose; Glutamine; In Vitro Techniques; Isoxazoles; Kidney Cortex; Microvilli; Oxazoles; Rats | 1986 |
Effects of inhibition and modulation of gamma-glutamyltransferase on glutamine and glutamate metabolism in control and acidotic rat proximal tubules.
Topics: Acidosis; Animals; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutamine; Hippurates; Isoxazoles; Kidney Tubules, Proximal; Male; Rats; Rats, Inbred Strains | 1987 |
Gamma glutamyltransferase contribution to renal ammoniagenesis in vivo.
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutamine; Isoxazoles; Kidney; Male; Models, Biological; p-Aminohippuric Acid; Rats; Rats, Inbred Strains | 1988 |
Acivicin reduces tumor growth during total parenteral nutrition (TPN).
Topics: Animals; Antimetabolites; Body Weight; Glutamine; Isoxazoles; Male; Neoplasm Transplantation; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Soft Tissue Neoplasms | 1987 |
The effects of acivicin on glutamine transport by renal basolateral membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; Glutamine; Isoxazoles; Kidney; Oxazoles; Rats | 1988 |
Reduction of tumor growth following treatment with a glutamine antimetabolite.
Topics: Amino Acids; Animals; Antibiotics, Antineoplastic; Antimetabolites; Body Weight; Energy Intake; Glutamine; Isoxazoles; Male; Methylcholanthrene; Oxazoles; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Azo Compounds; Biological Transport; Colonic Neoplasms; Diazooxonorleucine; Drug Resistance; Glutamine; Humans; Isoxazoles; Kinetics; Leukemia P388; Lung Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Tumor Cells, Cultured | 1988 |
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles | 1987 |
Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Colon; Colonic Neoplasms; Glutamine; Humans; Isoxazoles; Kinetics; Ligases; Oxazoles | 1985 |
In vivo inactivation of formylglycinamidine ribonucleotide synthetase in rat hepatoma.
Topics: Animals; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Glutamine; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains | 1985 |
Interaction of AT-125, (alpha S,5S)-amino-3-chloro-4,5-dihydroisoxazoleacetic acid, with bovine kidney gamma-glutamyl transpeptidase.
Topics: Anilides; Animals; Cattle; gamma-Glutamyltransferase; Glutamates; Glutamine; Glycine; In Vitro Techniques; Isoxazoles; Kidney; Kinetics; Oxazoles | 1981 |
Differential effect of AT-125 on rat renal glutaminase activities.
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Phosphates; Rats | 1981 |
Glutamine-dependent synthesis of citrulline by isolated hepatic mitochondria from Squalus acanthias.
Topics: Ammonia; Ammonium Chloride; Animals; Citrulline; Dogfish; Glutamates; Glutamic Acid; Glutamine; Isoxazoles; Methionine Sulfoximine; Mitochondria, Liver | 1984 |
Effect of L-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in P388 leukemia and in murine colon adenocarcinomas in vivo.
Topics: Adenocarcinoma; Animals; Azaserine; Colonic Neoplasms; Diazooxonorleucine; Glutamine; Intestine, Small; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Neoplasms, Experimental; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1982 |
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Dactinomycin; Deoxyribonucleotides; Glutamine; Humans; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Rats; Rats, Inbred Strains; Ribonucleotides; Sarcoma, Experimental | 1982 |
Acivicin: a new glutamine antagonist in clinical trials.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental | 1984 |
Phase I evaluation of AT-125 single dose every three weeks.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles | 1984 |
Glutamine- and N-acetyl-L-glutamate-dependent carbamoyl phosphate synthetase from Micropterus salmoides. Purification, properties, and inhibition by glutamine analogs.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Dogfish; Fishes; Glutamine; Isoxazoles; Kinetics; Ligases; Liver; Magnesium; Species Specificity | 1983 |
Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Anthranilate Synthase; Binding, Competitive; Glutamate Synthase; Glutamine; Glycine; Isoxazoles; Kinetics; Nitrogenous Group Transferases; Oxazoles; Serratia marcescens; Transferases | 1980 |
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Topics: Amidohydrolases; Animals; Asparagine; Azo Compounds; Cell Line; Diazooxonorleucine; DNA; Glutamine; Glycine; Isoxazoles; Kinetics; Leukemia L1210; Mice; Oxazoles; Temperature | 1981 |
The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Carbon-Nitrogen Ligases; Cysteine; Enzyme Inhibitors; Glutamine; Guanosine Monophosphate; Humans; Hydrolysis; In Vitro Techniques; Isoxazoles; Kinetics; Ligases; Molecular Sequence Data; Peptide Fragments | 1995 |
Extracellular glutamate flux regulates intracellular glutaminase activity in LLC-PK1-F+ cells.
Topics: Animals; Aspartic Acid; Cell Line; Extracellular Space; gamma-Glutamyltransferase; Glutamic Acid; Glutaminase; Glutamine; Intracellular Fluid; Isoxazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Models, Biological; Swine | 1995 |
Gamma-glutamyltranspeptidase expression regulates the growth-inhibitory activity of the anti-tumor prodrug gamma-L-glutaminyl-4-hydroxy-3-iodobenzene.
Topics: Animals; Antineoplastic Agents; Borates; Cell Division; CHO Cells; Cricetinae; gamma-Glutamyltransferase; Glutamine; Glutathione; Hydrolysis; Isoxazoles; Melanins; Melanoma, Experimental; Mice; Phenols; Prodrugs; Serine; Transfection | 1994 |
Regulation of orotic acid biosynthesis and excretion induced by oral glutamine administration in mice.
Topics: Administration, Oral; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Cycloheximide; Glutamine; Isoxazoles; Male; Mice; Mice, Inbred ICR; Mitochondria, Liver; Ornithine Decarboxylase; Ornithine-Oxo-Acid Transaminase; Orotic Acid | 1993 |
Glutamine-supported motility of adult filarial parasites in vitro and the effect of glutamine antimetabolites.
Topics: Animals; Antimetabolites; Antimycin A; Brugia pahangi; Culture Media; Dipetalonema; Female; Glucose; Glutamine; Hydrogen-Ion Concentration; Isoxazoles; Male; Movement; Onchocerca; Onchocerca volvulus; Potassium Cyanide; Sulfonamides | 1993 |
Prevention of diabetes in the spontaneously diabetic BB rat by the glutamine antimetabolite acivicin.
Topics: Animals; Blood Cell Count; Diabetes Mellitus, Type 1; Drug Interactions; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glucose Tolerance Test; Glutamic Acid; Glutamine; Ionomycin; Isoxazoles; Lymphocyte Subsets; Male; Rats; Rats, Inbred BB; Spleen; Tetradecanoylphorbol Acetate | 1996 |
Gamma-glutamyl peptides and related amino acids in rat hippocampus in vitro: effect of depolarization and gamma-glutamyl transpeptidase inhibition.
Topics: Amino Acids; Animals; Aspartic Acid; Cysteine; Dipeptides; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutamine; Glutathione; Hippocampus; Isoxazoles; Male; Rats; Rats, Sprague-Dawley | 1996 |
Glutamate transport modulation of paracellular permeability across LLC-PK1-F+ monolayers.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Epithelium; gamma-Glutamyltransferase; Glucose; Glutamic Acid; Glutamine; Isoxazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Models, Biological; Rabbits; Swine | 1996 |
gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists.
Topics: Azaserine; Diazooxonorleucine; Enzyme Inhibitors; gamma-Glutamyl Hydrolase; Glutamine; Humans; Isoxazoles; Kinetics; Methotrexate; Sarcoma; Substrate Specificity; Tumor Cells, Cultured | 1997 |
Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione.
Topics: Animals; Antioxidants; Astrocytes; Cell Survival; Cells, Cultured; Coculture Techniques; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutamine; Glutathione; Glycine; Isoxazoles; Neurons; Rats; Rats, Wistar | 1999 |
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Topics: 3C Viral Proteases; Antiviral Agents; Cell Line; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Glutamine; Humans; Isoxazoles; Lactams; Models, Molecular; Molecular Mimicry; Oligopeptides; Phenylalanine; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine; Viral Proteins | 1999 |
Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine.
Topics: Animals; Aspartic Acid; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Culture Media; Cytidine; Cytidine Triphosphate; Diazooxonorleucine; DNA Damage; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Glutamine; Isoxazoles; Ketoglutaric Acids; Kidney Tubules, Proximal; RNA, Messenger; Salts; Swine; Transcription Factor CHOP; Transcription Factors; Uridine | 1999 |
Identification of the site of glucocorticoid action on neutral amino acid transport in superficial nephrons of rat kidney.
Topics: Amino Acids; Animals; Dexamethasone; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glucocorticoids; Glutamic Acid; Glutamine; Isoxazoles; Kidney Cortex; Leucine; Nephrons; Punctures; Rats; Rats, Wistar | 2000 |
Mechanism for acivicin inactivation of triad glutamine amidotransferases.
Topics: Amino Acid Sequence; Aminohydrolases; Anthranilate Synthase; Azaserine; Binding, Competitive; Carbon-Nitrogen Ligases; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Diazooxonorleucine; Enzyme Inhibitors; Escherichia coli; Glutamine; Isoxazoles; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Nitrogenous Group Transferases; Ribonucleotides; Saccharomyces cerevisiae; Static Electricity; Stereoisomerism; Substrate Specificity | 2001 |
Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12.
Topics: Aminohydrolases; Anthranilate Synthase; Bacterial Proteins; Binding, Competitive; Culture Media; Enzyme Inhibitors; Escherichia coli; Gene Expression Profiling; Glutamine; Imidazoles; Isoxazoles; Nitrogenous Group Transferases; Ribonucleotides; Transaminases | 2001 |
On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.
Topics: Antioxidants; Bacillus subtilis; Binding Sites; Carbon-Nitrogen Lyases; Chromatography; Chromatography, Gel; Chromatography, High Pressure Liquid; Cloning, Molecular; Cysteine; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutaminase; Glutamine; Immunochemistry; Isoxazoles; Kinetics; Mass Spectrometry; Models, Chemical; Organophosphates; Oxidoreductases; Pentosephosphates; Protein Structure, Tertiary; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Threonine; Time Factors; Ultraviolet Rays; Vitamin B 6 | 2005 |
Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists.
Topics: Amino Acid Sequence; Animals; Azaserine; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli Proteins; gamma-Glutamyltransferase; Glutamine; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment | 2008 |
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Female; Glutaminase; Glutamine; Humans; In Vitro Techniques; Isoxazoles; Laminin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor A | 2008 |
Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartic Acid; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamine; Isoxazoles; Microdialysis; Neuronal Plasticity; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Prefrontal Cortex; Presynaptic Terminals; Rats; Receptors, Nicotinic; Synaptic Transmission; Synaptosomes | 2010 |
Ammonia channeling in Plasmodium falciparum GMP synthetase: investigation by NMR spectroscopy and biochemical assays.
Topics: Ammonia; Carbon-Nitrogen Ligases; Glutamine; Hydrogen-Ion Concentration; Isoxazoles; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Plasmodium falciparum | 2011 |
Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity.
Topics: Analysis of Variance; Caco-2 Cells; Dicarboxylic Acids; Enzyme Inhibitors; Epithelial Cells; gamma-Glutamyltransferase; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Humans; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Permeability; Phorbol 12,13-Dibutyrate; Pyrrolidines | 2011 |
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.
Topics: Animals; Antineoplastic Agents; Benzamides; Biological Availability; Cell Proliferation; Cytidine Triphosphate; Diphenylamine; Drosophila melanogaster; Drug Screening Assays, Antitumor; Glutamine; Isoxazoles; Neoplasms; Pharmacogenetics; Pilot Projects | 2013 |
Glutamine-induced production and secretion of Helicobacter pylori gamma-glutamyltranspeptidase at low pH and its putative role in glutathione transport.
Topics: Ammonium Chloride; Enzyme Activators; Enzyme Inhibitors; gamma-Glutamyltransferase; Gene Expression Profiling; Glutamine; Glutathione; Helicobacter pylori; Hydrogen-Ion Concentration; Isoxazoles; RNA, Messenger; Sodium Chloride | 2013 |
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.
Topics: Animals; Antifungal Agents; Candida; Candidiasis; Caspofungin; Cell Wall; Echinocandins; Glucosyltransferases; Glutamine; Isoxazoles; Lipopeptides; Mice; Microbial Sensitivity Tests; Protein Binding; Structure-Activity Relationship; Threonine | 2013 |