isoxazoles has been researched along with gaboxadol in 473 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 183 (38.69) | 18.7374 |
| 1990's | 76 (16.07) | 18.2507 |
| 2000's | 101 (21.35) | 29.6817 |
| 2010's | 107 (22.62) | 24.3611 |
| 2020's | 6 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Polc, P | 1 |
| Karobath, M; Lippitsch, M | 1 |
| Curtis, DR; Johnston, GA; Lodge, D | 1 |
| Aprison, MH; Lipkowitz, KB | 1 |
| Graeff, FG; Silveira, MC | 1 |
| Johnston, GA | 2 |
| Belhage, B; Hansen, GH; Schousboe, A | 2 |
| Garant, DS; Moshé, SL; Sperber, EF; Xu, SG | 2 |
| Bonaventure, N; Jardon, B; Kim, MS; Yücel, H | 1 |
| Amit, Z; Robidoux, J; Smith, BR | 1 |
| Amit, Z; Boyle, AE; Smith, BR | 1 |
| Ebbesson, SO; Erdö, SL; Hofmann, MH; Malz, CR; Meyer, DL | 1 |
| Snead, OC | 1 |
| Bapna, JS; Ramaswamy, S; Srinivasan, D | 1 |
| Bonaventure, N; Jardon, B | 1 |
| Ramsey, VA; Rosenberg, HC; Tietz, EI | 1 |
| Barolet, AW; Morris, ME | 1 |
| Diemer, NH; Johansen, FF | 1 |
| Agmo, A; Gutiérrez, M; Guzmán, M; Pruneda, R | 1 |
| Bergen, HT; Hejtmancik, JF; Pfaff, DW | 1 |
| Fromm, GH; Mukawa, J; Nakata, M | 1 |
| Heinricher, MM; Kaplan, HJ | 1 |
| Bapna, JS; Rajaram, S; Ramaswamy, S | 1 |
| Corbett, R; Cornfeldt, M; Dunn, RW; Fielding, S | 1 |
| Boelen, MK; Chubb, IW; Dowton, M; Morgan, IG; Wellard, J | 1 |
| Hablitz, JJ; Mistry, DK | 1 |
| Bapna, JS; Ramaswamy, S; Srinivasan, B; Srinivasan, D | 1 |
| Jodogne, C; Tirelli, E | 1 |
| Catt, KJ; Stojilković, SS; Virmani, MA | 1 |
| Belhage, B; Hansen, GH; Meier, E; Schousboe, A | 4 |
| Balcar, VJ; Dreher, B | 1 |
| Michler, A | 1 |
| Hicks, TP; Kaneko, T | 1 |
| Bonaventure, N; Jardon, B; Kim, MS; Yucel, YH | 1 |
| Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA | 1 |
| Amenta, F; Erdö, SL; Mione, MC; Wolff, JR | 1 |
| Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M | 1 |
| Agmo, A; Paredes, R; Soria, P | 1 |
| Erdö, SL; Michler, A | 1 |
| Liske, S; Morris, ME | 3 |
| Karlsson, G; Olpe, HR | 1 |
| Bapna, JS; Ramaswamy, S; Suthakaran, C | 1 |
| Andersen, JV; Dalgaard, L; Hansen, SH | 1 |
| Aarslew-Jensen, M; Diemer, NH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A | 1 |
| Graeff, FG; Milani, H | 1 |
| Fujimoto, M; Guidotti, A; Hanbauer, I; Kataoka, Y | 1 |
| Thalmann, RH | 2 |
| Pooler, GW; Steward, EG | 1 |
| Andre, JM; Boulanger, T; Durant, F; Vercauteren, DP | 1 |
| Cosi, C; Wood, PL | 1 |
| Spealman, RD; Wettstein, JG | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Bitran, D; Leipheimer, RE; McQuade, DB; Miller, SA; Sachs, BD | 1 |
| Beani, L; Bianchi, C; Tanganelli, S | 1 |
| Bond, A; Neal, H | 2 |
| Hansen, SH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A | 1 |
| Meldrum, BS | 1 |
| Ator, NA; Griffiths, RR | 1 |
| Bruno, G; Chase, TN; Cox, C; Fedio, P; Foster, N; Gillespie, M; Hare, TA; Mohr, E; Tamminga, C | 1 |
| Alho, H; Fujimoto, M; Geffard, M; Guidotti, A; Hanbauer, I; Kataoka, Y; Kelly, GD | 1 |
| Borsini, F; Giuliani, S; Meli, A | 2 |
| Andersson, U; Häggström, JE | 1 |
| Bagri, A; Di Scala, G; Sandner, G | 1 |
| Karobath, M; Supavilai, P | 3 |
| Iversen, LL; Wong, EH | 1 |
| Chrousos, GP; Crawley, JN; Linnoila, M; Ninan, PT; Paul, SM; Pickar, D; Skolnick, P | 1 |
| Chweh, AY; Kupferberg, HJ; Swinyard, EA; Wolf, HH | 1 |
| Costa, LG; Enna, SJ; Pelley, K; Setler, P; Vaught, JL | 1 |
| Gianutsos, G; Suzdak, PD | 2 |
| Agmo, A; Paredes, R | 1 |
| Löscher, W; Schwark, WS | 1 |
| Gähwiler, BH; Graff, P; Maurer, R; Nordmann, R | 1 |
| Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM | 2 |
| Agmo, A; Giordano, M | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Nielsen, L | 1 |
| Depaulis, A; Liebeskind, JC; Morgan, MM | 2 |
| Depaulis, A; Vergnes, M | 4 |
| Brandao, ML; Di Scala, G; Karli, P; Schmitt, P | 1 |
| Hösli, E; Hösli, L; Krogsgaard-Larsen, P | 1 |
| Bristow, DR; Watling, KJ | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA | 1 |
| Chweh, AY; Lin-Michell, E; Swinyard, EA | 1 |
| Allan, AM; Harris, RA | 1 |
| Ciesielski, L; Gobaille, S; Mandel, P; Molina, V | 1 |
| Belhage, B; Meier, E; Schousboe, A | 1 |
| Falch, E; Hjeds, H; Krogsgaard-Larsen, P | 1 |
| Braestrup, C; Krogsgaard-Larsen, P; Nielsen, M | 1 |
| Dafny, N; Enna, SJ; Reyes-Vazquez, C | 1 |
| Shavrin, AS; Zharkovskaia, TA; Zharkovskiĭ, AM | 1 |
| Apud, JA; Masotto, C; Racagni, G | 1 |
| Alphs, LD; Ferraro, TN; Hare, TA; Lafferman, J; Tamminga, CA; Thaker, GK | 1 |
| Audi, EA; Graeff, FG | 1 |
| Chweh, AY; Swinyard, EA; Wolf, HH | 1 |
| Lindgren, S | 1 |
| Zharkovskaia, TA; Zharkovskiĭ, AM | 1 |
| DaSilva, AM; Gatti, PJ; Gillis, RA | 1 |
| Enna, SJ; Zorn, SH | 2 |
| Gillis, RA; Hamosh, P; Hartley, B; Quest, JA; Taveira da Silva, AM | 1 |
| Chapman, AG | 1 |
| Löscher, W | 2 |
| Brunner, EA; Cheng, SC | 1 |
| Friberg, L; Roland, PE | 1 |
| Drower, EJ; Hammond, DL | 2 |
| Pelley, KA; Vaught, JL | 1 |
| Zarkovsky, AM | 1 |
| Liebeskind, JC; Morgan, MM; Stein, C | 1 |
| Jørgensen, OS; Meier, E; Schousboe, A | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Ford, I; Kelly, PA; McCulloch, J | 1 |
| Bennett, JP; Cruz, CJ; Ferrari, MB | 1 |
| Beart, PM; Lloyd, KG; Scatton, B | 1 |
| Bloss, JL; Hammond, DL | 1 |
| Sawynok, J | 1 |
| Ben-Ari, Y; Cherubini, E; Rovira, C | 1 |
| Meldrum, B | 1 |
| Maksay, G; Ticku, MK | 2 |
| Minchin, MC; Nutt, DJ | 1 |
| Jensen, MS; Lambert, JD | 1 |
| Arnt, J; Christensen, AV | 1 |
| Bauer, B | 1 |
| Casey, DE; Gerlach, J; Hetmar, O; Kaldan, B; Korsgaard, S; Mikkelsen, LB | 1 |
| Forchetti, MC; Guidotti, A; Krogsgaard-Larsen, P; Moroni, F | 1 |
| Persson, B | 1 |
| Drejer, J; Meier, E; Schousboe, A | 1 |
| Chase, TN; Denaro, A; Foster, NL; Hare, TA; Tamminga, CA | 1 |
| Cross, AJ; Waddington, JL | 1 |
| Benson, DI; Klepner, CA; Squires, RF | 1 |
| Krogsgaard-Larsen, P | 1 |
| Kelly, PA; McCulloch, J | 2 |
| Aaes-Jørgensen, T; Bøgesø, KP; Krogsgaard-Larsen, P; Mikkelsen, H; Schultz, B | 1 |
| Carmona, E; Gomes, C; Trolin, G | 1 |
| Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K | 1 |
| Falch, E; Krogsgaard-Larsen, P | 1 |
| Blavet, N; Clostre, F; DeFeudis, FV | 1 |
| Blavet, N; Clostre, F; De Feudis, FV | 1 |
| Wood, PL | 1 |
| Dias Souza, J; Gillis, RA; Quest, JA; Williford, DJ | 1 |
| Curtis, DR; Hjeds, H; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ | 1 |
| Dutton, GR; Freedman, EG; Pearce, BR | 1 |
| Breese, GR; Frye, GD | 1 |
| Saederup, E; Squires, RF | 1 |
| Christensen, AV; Krogsgaard-Larsen, P; Svendsen, O | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Mondrup, K; Pedersen, E | 1 |
| Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ | 1 |
| Breese, GR; Frye, GD; McCown, TJ | 1 |
| Madtes, P; Redburn, DA | 1 |
| Johnston, GA; Skerritt, JH | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ | 1 |
| Deisz, RA; Dose, M | 1 |
| Appel, JB; Holohean, AM; Nielsen, EB; Valentine, JD | 1 |
| Costa, LG; Murphy, SD | 1 |
| Bloch, R; Bousquet, P; Feldman, J; Schwartz, J | 1 |
| Dafny, N; Reyes-Vázquez, C | 1 |
| Bank-Mikkelsen, OK; Valentin, N | 1 |
| Bjørndal, N; Casey, DE; Christensson, E; Gerlach, J | 1 |
| Frey, HH; Löscher, W; Reiche, R; Schultz, D | 1 |
| Hoehn-Saric, R | 1 |
| Altmann, H; Dose, M; Emrich, HM; von Zerssen, D | 1 |
| Hare, TA; Tamminga, CA; Thaker, GK | 1 |
| Bjørndal, N; Christensson, E; Gerlach, J | 1 |
| Di Scala, G; Karli, P; Schmitt, P | 2 |
| Fariello, RG; Golden, GT | 1 |
| Baumeister, AA; Frye, GD | 1 |
| DeFeudis, FV | 1 |
| Kjaer, M; Nielsen, H | 1 |
| Følsgård, S; Jacobsen, E; Lindeburg, T; Madsen, SM; Sillesen, H | 1 |
| DeFeudis, FV; Grognet, A; Hertz, F | 3 |
| Agnoli, A; Chase, TN; Denaro, A; Ruggieri, S; Tamminga, CA | 1 |
| Mueller, AL; Schwartzkroin, PA; Taube, JS | 1 |
| Macdonald, RL; Skerritt, JH | 1 |
| Horton, R; Meldrum, B | 1 |
| Coward, DM | 1 |
| Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H | 1 |
| Andree, T; Enna, SJ; Kendall, DA | 1 |
| Dam, M; Jensen, I; Petersen, HR | 1 |
| Cheney, DL; McGill, W; Murray, TF | 1 |
| Madsen, SM | 1 |
| Maugh, TH | 1 |
| Cagiano, R; Cuomo, V; Mocchetti, I; Racagni, G | 1 |
| Alger, BE; Nicoll, RA | 1 |
| Christensen, AV; Larsen, JJ | 1 |
| Buescher, HH; Hill, RC; Maurer, R; Roemer, D | 1 |
| Kuhar, MJ; London, ED; Palacios, JM; Rapoport, SI | 1 |
| Magelund, G; Scheel-Krüger, J | 1 |
| Ashton, D; Geerts, R; Leysen, JE; Waterkeyn, C | 1 |
| Menon, MK | 1 |
| Aaes-Jørgensen, T; Bøgesø, KP; Jørgensen, A; Schultz, B | 1 |
| Clark, WG; Menon, MK; Vivonia, C | 1 |
| Hruska, RE; Walters, JR; Waszczak, BL | 1 |
| Walters, JR; Waszczak, BL | 1 |
| Delorey, TM; Endo, S; Huh, KH; Olsen, RW | 1 |
| Belhage, B; Elster, L; Fritschy, JM; Hansen, GH; Möhler, H; Schousboe, A | 1 |
| Brehm, L; Falch, E; Frølund, B; Hansen, AB; Kristiansen, U; Krogsgaard-Larsen, P | 1 |
| Cinotti, L; Froment, JC; Galy, G; Garcia-Larrea, L; Krogsgaard-Larsen, P; Landais, P; Lavenne, F; Le Bars, D; Millet, P; Peyron, R | 2 |
| Elster, L; Saederup, E; Schousboe, A; Squires, RF | 1 |
| Damgaard, I; Elster, L; Kardos, J; Krogsgaard-Larsen, P; Schousboe, A | 1 |
| Abraham, JH; Schousboe, A; Seiler, N | 1 |
| Ebert, B; Kemp, JA; Krogsgaard-Larsen, P; Wafford, KA; Whiting, PJ | 1 |
| Anderson, CA; Faingold, CL; Randall, ME | 1 |
| Kim, HY; Olsen, RW; Sapp, DW; Tobin, AJ | 1 |
| Amit, Z; Boyle, AE; Segal, R; Smith, BR | 1 |
| Buur, JR; Hjeds, H; Jørgensen, FS; Krogsgaard-Larsen, P | 1 |
| Barnes, EM; Calkin, PA | 1 |
| Batini, C; Billard, JM; Vigot, R | 1 |
| Bapna, JS; Ramaswamy, S; Thirugnanasambantham, P; Viswanathan, S | 1 |
| Abraham, JH; Hansen, GH; Schousboe, A; Seiler, N | 1 |
| Barnes, EM; Tehrani, MH | 1 |
| Morishita, W; Sastry, BR | 1 |
| Faulhaber, J; Lancel, M | 1 |
| Baylis, HA; Buckingham, SD; Hosie, AM; Matsuda, K; Sattelle, DB; Squire, MD | 1 |
| Alger, BE; Kirov, SA; Lenz, RA; Martin, LA; Morishita, W; Pitler, TA | 1 |
| Matsutani, S; Yamamoto, N | 1 |
| Faulhaber, J; Lancel, M; Steiger, A | 1 |
| Agmo, A; Highland, L; Karam, P; Paredes, RG | 1 |
| Ebert, B; Krogsgaard-Larsen, P; McKernan, R; Saounatsou, K; Thompson, SA; Wafford, KA | 1 |
| Hetzler, BE; Zeisset, HL | 1 |
| Geter-Douglass, B; Tirelli, E; Witkin, JM | 1 |
| Aleo, MD; Miller, GW; Schnellmann, RG; Waters, SL | 1 |
| Belhage, B; Carlson, BX; Elster, L; Hansen, GH; Olsen, RW; Schousboe, A | 1 |
| Lancel, M | 1 |
| Kulinskiĭ, VI; Mikhel'son, GV | 2 |
| Damgaard, I; Rodríguez-Farré, E; Schousboe, A; Suñol, C; Vale, C | 1 |
| Bedingfield, JB; Calder, LD; Karler, R; Thai, DK | 1 |
| Eriksson, B; Magnusson, AK; Tham, R | 1 |
| Agmo, A; Contreras, JL; Paredes, RG | 1 |
| Dzubay, JA; Jones, MV; Sahara, Y; Westbrook, GL | 1 |
| Broadbent, J; Harless, WE | 1 |
| Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA | 1 |
| Faingold, CL; N'Gouemo, P | 1 |
| Asnis, N; Barros, HM; Gomez, R; Tannhauser, SL | 1 |
| Burgard, EC; Haas, KF; Macdonald, RL | 1 |
| Firestone, LL; Hammond, DL; Homanics, GE; Ugarte, SD | 1 |
| Lancel, M; Langebartels, A | 1 |
| Maksay, G; McKernan, R | 1 |
| Allikmets, L; Matto, V; Pruus, K; Rudissaar, R; Skrebuhhova-Malmros, T | 1 |
| Ebert, B; Fjalland, B; Hansen, SL; Kristiansen, U | 1 |
| Lancel, M; Mathias, S; Steiger, A; Wetter, TC | 1 |
| Lancel, M; Mathias, S; Steiger, A | 1 |
| Jonas, P; Jones, MV; Sahara, Y; Westbrook, GL | 1 |
| de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Hokoç, JN; Loureiro dos Santos, NE; Yamasaki, EN | 1 |
| Hong, JT; Lee, MK; Oh, KW; Shin, IC; Yoon, IS | 1 |
| Ebert, B; Frølund, B; Kristiansen, U; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Ebert, B; Frølund, B; i Storustovu, S; Mortensen, M | 1 |
| Brünig, I; Fritschy, JM; Studler, B | 1 |
| Platt, B; White, AM | 1 |
| Frølund, B; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Alva, H; Blednov, YA; Harris, RA; Jung, S; Rosahl, T; Wallace, D; Whiting, PJ | 1 |
| Gong, QH; Gulinello, M; Smith, SS | 1 |
| Ebert, B; Stórustovu, Sí | 2 |
| Kristensen, BW; Noraberg, J; Zimmer, J | 1 |
| Birnir, B; Ebert, B; Lindquist, CE | 1 |
| Birnir, B; Lindquist, CE; Smith, M | 1 |
| Chebib, M; Ebert, B; Frølund, B; Johnston, GA; Krehan, D; Krogsgaard-Larsen, P; Nielsen, B | 1 |
| Ebert, B; Michelsen, S; Sanchez, C; Voss, J | 1 |
| Frosini, M; Sgaragli, G; Valoti, M | 1 |
| Beyer, C; García-Juárez, M; González-Flores, O; González-Mariscal, G; Lima-Hernández, FJ; Sánchez, N | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Blednov, YA; Boehm, SL; Harris, RA; Peden, L | 1 |
| Cagetti, E; Liang, J; Olsen, RW; Spigelman, I | 1 |
| Babich, M; Branda, EM; Elfline, GS; Quock, RM | 1 |
| Huckle, R | 1 |
| Ebert, B; Frølund, B; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Barry, PH; Carland, JE; Chebib, M; Johnston, GA; Moorhouse, AJ | 1 |
| Lancel, M; Mathias, S; Steiger, A; Zihl, J | 1 |
| Fritschy, JM; Sidler, C; van Rijnsoever, C | 1 |
| France, CP; McMahon, LR | 1 |
| Bösch, G; Kopp, C; Tobler, I; Vyazovskiy, VV | 1 |
| Abílio, VC; Araujo, NP; Castro, JP; Faria, RR; Frussa-Filho, R; Fukushiro, DF; Medrano, WA; Peixoto, MF; Silva, RH; Zanier-Gomes, PH | 1 |
| Chan, GC; Maas, JW; Muglia, LJ; Pineda, VV; Storm, DR; Vogt, SK | 1 |
| Bjerrum, OJ; Blackburn-Munro, G; Jensen, DG; Rode, F | 1 |
| Gong, QH; Shen, H; Smith, SS; Yuan, M | 1 |
| Biggio, F; Biggio, G; Busonero, F; Caria, S; Follesa, P; Gorini, G; Mostallino, MC; Mura, ML; Murru, L; Sanna, E | 1 |
| Goldstein, PA; Harrison, NL; Jia, F; Pignataro, L; Schofield, CM; Yue, M | 1 |
| Drasbek, KR; Jensen, K | 1 |
| Ebert, B; Wafford, KA | 1 |
| Korpi, ER; Möykkynen, T; Ranna, M; Sinkkonen, ST; Uusi-Oukari, M | 1 |
| Jia, H; Qu, CL; Tang, JS | 1 |
| Gartside, SE; Ingram, CD; Judge, SJ; Kaura, V; Young, AH | 1 |
| Blednov, YA; Boehm, SL; Harris, RA; Homanics, GE | 1 |
| Steiger, A | 1 |
| Airaksinen, MS; Kulesskaya, N; Segerstråle, M; Taira, T; Tornberg, J; Voikar, V | 1 |
| Chandra, D; Harrison, NL; Homanics, GE; Houser, CR; Jia, F; Liang, J; Olsen, RW; Peng, Z; Spigelman, I; Suryanarayanan, A; Werner, DF | 1 |
| Davies, M; Derry, JM; Dunn, SM; Paulsen, IM | 1 |
| Allgaier, C; Rassler, C; Strecker, K; Wegner, F; Wohlfarth, K | 1 |
| Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD | 2 |
| Drasbek, KR; Hoestgaard-Jensen, K; Jensen, K | 1 |
| Ebert, B; Michelsen, S; Sánchez, C | 1 |
| Cremers, T; Ebert, B | 1 |
| Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M | 1 |
| Homanics, GE; Tobler, I; Vyazovskiy, VV; Winsky-Sommerer, R | 1 |
| Deacon, S; Legters, A; Loft, H; Lundahl, J; Staner, C; Staner, L | 1 |
| Park, JB; Skalska, S; Son, S; Stern, JE | 1 |
| Deacon, S; Dijk, DJ; Lundahl, J; Walsh, JK | 1 |
| Orser, BA | 1 |
| Deacon, S; Loft, H; Lundahl, J; Staner, C; Staner, L | 1 |
| Brust, P; Deuther-Conrad, W; Ebert, B; Friemel, A; Hutson, PH; Nieber, K | 1 |
| Boehm, SL; Goldfarb, KJ; Linsenbardt, DN; Moore, EM; Serio, KM; Stepanovska, S | 1 |
| Deacon, S; Guico-Pabia, C; Martinez, R; Mayleben, D; Vandormael, K; Walsh, JK | 1 |
| Dige, T; Fu, I; Jørgensen, M; Kall, MA; Vallano, P; Woolf, E | 1 |
| Korpi, ER; Linden, AM; Lüddens, H; Möykkynen, T; Rabe, H; Ranna, M; Saarelainen, KS; Sinkkonen, ST; Uusi-Oukari, M | 1 |
| Belelli, D; Haythornthwaite, AR; Herd, MB; Homanics, GE; Lambert, JJ; Rosahl, TW; Wafford, KA | 1 |
| Harrison, NL; Keramidas, A | 1 |
| Adrien, J; Aixendri, R; Alexandre, C; Dordal, A; Guzman, A; Hamon, M | 1 |
| Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V | 1 |
| McCarley, RW; Thakkar, MM; Winston, S | 1 |
| Dósa, Z; Drasbek, KR; Jensen, K; Vardya, I | 1 |
| Huntsman, MM; Krook-Magnuson, EI; Li, P; Paluszkiewicz, SM | 1 |
| Volgin, DV | 1 |
| Dickey, P; Eisenstein, R; Feren, SD; Griffin, K; Groeger, J; Hall, J; Randazzo, AC; Schweitzer, PK; Snyder, E; Walsh, JK | 1 |
| Amar, M; Baux, G; Fossier, P; Le Roux, N; Moreau, A | 1 |
| Akabas, MH; Dannhardt, G; Debus, F; Dieler, S; Jansen, M; Lüddens, H; Rabe, H; Strehle, A | 1 |
| Ahring, PK; Erichsen, HK; Larsen, JS; Lopez-Garcia, JA; Mirza, NR; Munro, G; Nielsen, EØ; Rivera-Arconada, I | 1 |
| Corser, BC; Deacon, S; Lankford, DA; Li, Z; Lines, CR; Snavely, DB; Zheng, YP | 1 |
| Boyle, J; Cerchio, K; Cummings, C; Gargano, C; Lines, C; McCrea, J; Wolford, D | 1 |
| Anari, MR; Braun, MP; Cai, X; Chu, XY; Cuevas-Licea, K; Doss, GA; Evers, R; Kassahun, K; Liang, Y; Rippley, RK; Shou, M | 1 |
| Agrawal, N; Alexander, R; Boyle, J; Calder, N; Danjou, P; Fu, I; Gargano, C; McCrea, JB; Murphy, MG | 1 |
| Cremers, TI; De Lange, EC; de Vries, MG; Ebert, B; Huinink, KD; v d Hart, M; van Loon, JP; Westerink, BH | 1 |
| Cook, JM; Groenink, L; Hopkins, SC; Klanker, M; Korte, SM; Olivier, B; Van Linn, ML; Vinkers, CH | 1 |
| Ehlen, JC; Paul, KN | 1 |
| Balfour, DJ; Belelli, D; Brown, VJ; Chandra, D; Foister, N; Herd, MB; Homanics, GE; Lambert, JJ; Peden, DR | 1 |
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| Charbonnet, M; Gold, MS; Lee, KY | 1 |
| Bétry, C; Christensen, T; Ebert, B; Etievant, A; Haddjeri, N; Mnie-Filali, O; Wiborg, O | 1 |
| Barberis, A; Benfenati, F; Cancedda, L; Fiumelli, H; Succol, F | 1 |
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| Broberg, Ml; Brodin, B; Christensen, KV; Ewon, KB; Frølund, S; Holm, R; Jensen, A; Kall, MA; Nielsen, Al; Nielsen, CU; Tønsberg, H | 1 |
| Boddum, K; Dalby, NO; Dósa, Z; Ebert, B; Hoestgaard-Jensen, K; Holm, MM; Jensen, K; Jones, KA; Nieto-Gonzalez, JL; Vardya, I; Wolinsky, TD | 1 |
| Abbassi, L; Denbow, DM; Jonaidi, H; Kaiya, H; Kamali, Y; Shojaei, B; Yaghoobi, MM | 1 |
| Finn, DA; Ford, MM; Ramaker, MJ; Strong, MN | 1 |
| Frølund, S; Holm, R; Kall, MA; Langthaler, L; Nielsen, CU | 1 |
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| Chen, G; Jiang, D; Kong, S; Pitre, A; Sun, Y; Wang, Y; Wu, Z | 1 |
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| Abdulhadi, S; Brodin, B; Frølund, S; Holm, R; Kall, MA; Langthaler, L; Nielsen, CU; Nøhr, MK; Sari, H | 1 |
| Karakossian, MH; Meera, P; Otis, TS; Santhakumar, V | 1 |
| Eng, D; Lecker, I; Martin, LJ; Orser, BA; Wang, DS; Whissell, PD | 1 |
| Caspary, DM; Duque, D; Malmierca, MS | 1 |
| Brozoski, TJ; Cai, R; Caspary, DM; Kalappa, BI; Ling, LL | 1 |
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| Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG | 1 |
| Blomquist, SL; Diaz, MR; Everett, JC; Morton, RA; Orser, BA; Valenzuela, CF; Vollmer, CC; Vollmer, W; Yu, J; Zamudio-Bulcock, PA; Zurek, AA | 1 |
| Luo, R; Partridge, JG; Vicini, S | 1 |
| Dvorzhak, A; Grantyn, R; Semtner, M; Wójtowicz, AM | 1 |
| Alò, R; Avolio, E; Canonaco, A; Canonaco, M; Carelli, A; Mele, M; Storino, F | 1 |
| Brazhe, A; Jensen, K; Jessen, SB; Lauritzen, M; Lind, BL; Mathiesen, C; Thomsen, K | 1 |
| Marowsky, A; Vogt, KE | 1 |
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| Bavley, RL; Blomstrom, KJ; Fomalont, K; Mitz, AR; Murray, EA; Rudebeck, PH; Turchi, J; Yang, T | 1 |
| Finn, DA; Ford, MM; Phillips, TJ; Ramaker, MJ | 1 |
| Corbin, JG; Huntsman, MM; Martin, BS | 1 |
| Gangadharan, G; Hwang, EM; Lee, B; Lee, S; Paydar, A; Shin, HS | 1 |
| Baldelli, P; Benfenati, F; Ferrea, E; Greco, B; Medrihan, L | 1 |
| Boehm, SL; Fritz, BM | 1 |
| Lingford-Hughes, A; Muthukumaraswamy, S; Myers, J; Nutt, D; Papadopoulos, A; Wilson, S | 1 |
| Herring, WJ; Lines, C; Ma, J; Roth, T; Snyder, E; Svetnik, V | 1 |
| Cheng, L; Dargham, RA; Kong, S; Liu, X; Ren, W; Wan, L; Wang, Y; Wu, Z | 1 |
| Finn, DA; Ford, MM; Phillips, TJ; Ramaker, MJ; Strong-Kaufman, MN | 1 |
| Babateen, O; Bhandage, A; Birnir, B; Forsberg Nilsson, K; Jin, Z; Korol, SV; Smits, A; Uhrbom, L; Westermark, B | 1 |
| Hellsten, KS; Korpi, ER; Linden, AM | 1 |
| Brooks-Kayal, A; Carlsen, J; Cea-Del Rio, CA; Cruz Del Angel, Y; González, MI; Grabenstatter, HL; Huntsman, MM; Laoprasert, RP; White, AM | 1 |
| Angadi, V; Dissel, S; Donlea, J; English, D; Kirszenblat, L; Klose, M; Koch, Z; Shaw, PJ; Suzuki, Y; van Swinderen, B; Winsky-Sommerer, R | 1 |
| Bondy, B; Cui, N; Jiang, C; Jin, X; Johnson, CM; Oginsky, MF; Wu, Y; Zhang, S; Zhong, W | 1 |
| Boychuk, CR; Halmos, KC; Smith, BN | 1 |
| Berry, JA; Cervantes-Sandoval, I; Chakraborty, M; Davis, RL | 1 |
| Chen, HJ; Corcoran, KA; Guedea, AL; Jovasevic, V; Leaderbrand, K; Radulovic, J; Shepherd, GM; Yamawaki, N | 1 |
| Balakrishnan, A; Kesisoglou, F; Manser, K | 1 |
| Bohnsack, JP; Carlson, SL; Morrow, AL; Patel, V | 1 |
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| Holm, R; Lagunas, C; Nielsen, CU; Plum, J; Rasmussen, RN | 1 |
| Cetina, Y; Houser, CR; Huang, CS; Otis, TS; Peng, Z; Tong, X; Wallner, M; Zhang, N | 1 |
| Boychuk, JA; Butler, CR; Halmos, KC; Smith, BN | 1 |
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| Gerak, LR; Ibarra, MH; Pressly, JD; Smith, KR; Zanettini, C | 1 |
| Astafurov, K; Dow-Edwards, D; Nestler, EJ; Popp, S; Silverman, NS; Vialou, V | 1 |
| Boychuk, JA; Butler, CR; Smith, BN | 1 |
| Absalom, NL; Ahring, PK; Chebib, M; Hanrahan, JR; Lee, HJ; van Nieuwenhuijzen, P | 1 |
| Merlin, LR; Shen, H; Smith, SS; Yang, L | 1 |
| Finn, DA; Helms, M; Jensen, J; Kaplan, JS; Nipper, MA; Richardson, BD; Rossi, DJ | 1 |
| Johnston, GAR | 1 |
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| Chaussenot, R; Vaillend, C | 1 |
| Cai, J; Chen, RX; Liao, FF; Liu, FY; Wan, Y; Wang, J; Xu, FQ; Yi, M; Zhang, C; Zhang, Y | 1 |
| Afroz, S; Shen, H; Smith, SS | 1 |
| Browning, KN; McMenamin, CA; Travagli, RA | 1 |
| Babapour, V; Hashemzadeh, M; Panahi, N; Zendehdel, M | 1 |
| Grabowska, MJ; Jeans, R; Paulk, AC; Rohrscheib, C; Shaw, PJ; Troup, M; van Alphen, B; van Swinderen, B; Yap, MHW | 1 |
| Duan, XL; He, YT; Hu, XD; Liu, JP; Suo, ZW; Yang, X | 1 |
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| Crawley, JN; Kazdoba, TM; Parrott, JM; Rhine, MA; Schultz, MN | 1 |
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| Herring, WJ; Lines, C; Roth, T; Snyder, ES; Svetnik, V; Tao, P | 1 |
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| Bird, LM; Burdine, RD; During, MJ; Heimer, G; Holcroft, C; Kolevzon, A; Melmed, RD; Ochoa-Lubinoff, C; Rakhit, A; Tan, WH; Thibert, RL; Visootsak, J | 1 |
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21 review(s) available for isoxazoles and gaboxadol
| Article | Year |
|---|---|
GABAA agonists as targets for drug development.
Topics: Acetates; Acrylates; Amines; Analgesics; Anthelmintics; Anticonvulsants; Bicuculline; Computer Simulation; Cyclohexanecarboxylic Acids; Cyclopentanes; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Molecular Weight; Receptors, GABA-A | 1992 |
Pharmacological models of generalized absence seizures in rodents.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rodentia; Sodium Oxybate; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1992 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Heterocyclic analogues of GABA: chemistry, molecular pharmacology and therapeutic aspects.
Topics: Analgesics; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Nipecotic Acids; Receptors, GABA-A | 1985 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid | 1986 |
Inhibitors of the GABA uptake systems.
Topics: Animals; Astrocytes; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoxazoles; Muscimol; Neuroglia; Neurons; Nipecotic Acids; Receptors, Neurotransmitter; Structure-Activity Relationship; Synapses; Synaptosomes | 1980 |
THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.
Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Oxazoles; Pipecolic Acids; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1981 |
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
Topics: Agaricales; Amanita; Animals; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Structural; Molecular Conformation; Muscimol; Nipecotic Acids; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism | 1981 |
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.
Topics: Analgesics; Animals; Brain; gamma-Aminobutyric Acid; Humans; Isoxazoles; Methylphenidate; Neurons; Oxazoles; Stereotyped Behavior; Synaptic Transmission | 1982 |
Molecular pharmacology of the GABA receptors and GABA agonists.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Humans; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism; Synapses | 1983 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin | 1983 |
GABA(A) receptor ligands and their therapeutic potentials.
Topics: Animals; Central Nervous System Diseases; GABA Agents; GABA Agonists; GABA Antagonists; Humans; Isonicotinic Acids; Isoxazoles; Ligands; Muscimol; Piperidines; Protein Subunits; Receptors, GABA-A | 2002 |
Medicinal chemistry and molecular pharmacology of GABA(C) receptors.
Topics: Amino Acids, Cyclic; Animals; Barbiturates; Crotonates; GABA Agonists; GABA Antagonists; Imidazoles; Isoxazoles; Muscimol; Organophosphorus Compounds; Phosphinic Acids; Pyridines; Receptors, GABA; Receptors, GABA-A | 2002 |
Specific GABA(A) agonists and partial agonists.
Topics: Benzodiazepines; GABA Agonists; GABA-A Receptor Agonists; Humans; Isoxazoles; Nervous System; Neurotransmitter Agents; Receptors, GABA-A; Steroids | 2002 |
Gaboxadol--a new awakening in sleep.
Topics: Animals; Benzodiazepines; Clinical Trials as Topic; Drug Interactions; Ethanol; GABA Agonists; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Receptors, GABA-A; Sleep; Sleep Initiation and Maintenance Disorders; Thalamus | 2006 |
Neurochemical regulation of sleep.
Topics: Brain; Corticotropin-Releasing Hormone; Electroencephalography; Estrogens; GABA Agonists; GABA-A Receptor Agonists; Growth Hormone-Releasing Hormone; Hormone Replacement Therapy; Humans; Hypnotics and Sedatives; Hypothalamo-Hypophyseal System; Isoxazoles; Neuropeptides; Nipecotic Acids; Pituitary-Adrenal System; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tiagabine | 2007 |
Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.
Topics: Brain; GABA Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Receptors, GABA-A; Sleep Initiation and Maintenance Disorders; Synapses | 2006 |
Enhancement of slow wave sleep: implications for insomnia.
Topics: Electroencephalography; GABA Agonists; Humans; Isoxazoles; Nipecotic Acids; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tiagabine | 2009 |
GABA Australis, some reflections on the history of GABA receptor research in Australia.
Topics: Animals; Australia; Baclofen; Bicuculline; Cyclic AMP; Humans; Isoxazoles; Muscimol; Receptors, GABA | 2017 |
Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia.
Topics: Antipsychotic Agents; Baclofen; Dyskinesia, Drug-Induced; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Placebos; Randomized Controlled Trials as Topic; Valproic Acid | 2018 |
Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome.
Topics: Angelman Syndrome; Animals; Anticonvulsants; Biological Products; Genetic Therapy; Humans; Isoxazoles; Neurodevelopmental Disorders; Recombinant Fusion Proteins; RNA, Antisense; Ubiquitin-Protein Ligases | 2021 |
34 trial(s) available for isoxazoles and gaboxadol
| Article | Year |
|---|---|
GABA-agonist therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Isoxazoles; Middle Aged; Neuropsychological Tests; Oxazoles; Somatostatin | 1986 |
Brain gamma-aminobutyric acid abnormality in tardive dyskinesia. Reduction in cerebrospinal fluid GABA levels and therapeutic response to GABA agonist treatment.
Topics: Adult; Aminocaproates; Brain; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Receptors, GABA-A; Schizophrenia; Vigabatrin | 1987 |
The effect of tetrahydroisoxazolopyridinol (THIP) in tardive dyskinesia: a new gamma-aminobutyric acid agonist.
Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Blinking; Clinical Trials as Topic; Confusion; Dizziness; Dyskinesia, Drug-Induced; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Oxazoles; Parkinson Disease, Secondary; Placebos; Vomiting | 1982 |
THIP treatment of Huntington's disease.
Topics: Adult; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Female; Homovanillic Acid; Humans; Huntington Disease; Isoxazoles; Male; Middle Aged; Oxazoles | 1983 |
Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia.
Topics: Adolescent; Adult; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Halothane; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Respiration | 1983 |
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid | 1983 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin | 1983 |
THIP: a single-blind controlled trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles | 1983 |
Analgesic from mushrooms begins clinical trials.
Topics: Analgesics; Clinical Trials as Topic; Humans; Isoxazoles; Oxazoles | 1981 |
Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activation.
Topics: Adult; Behavior; Brain; Epilepsy, Temporal Lobe; Female; Fluorine Radioisotopes; GABA Agonists; Glucose; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Radioligand Assay; Receptors, GABA-A; Reference Values; Tomography, Emission-Computed | 1994 |
Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TL
Topics: Adult; Brain; Epilepsy, Temporal Lobe; Female; Fluorine Radioisotopes; GABA Agonists; Glucose; Humans; Isoxazoles; Male; Middle Aged; Radioligand Assay; Receptors, GABA-A; Reference Values; Tomography, Emission-Computed | 1994 |
The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans.
Topics: Adult; Double-Blind Method; GABA Agonists; Humans; Isoxazoles; Male; Receptors, GABA-A; Sleep Stages; Sleep, REM | 1997 |
The GABA(A) agonist gaboxadol improves the quality of post-nap sleep.
Topics: Adult; Electroencephalography; GABA Agonists; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Polysomnography; Sleep; Sleep Stages | 2001 |
Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects.
Topics: Activities of Daily Living; Aged; Attention; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Electroencephalography; Female; GABA Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Memory; Middle Aged; Neuropsychological Tests; Placebo Effect; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Wakefulness | 2005 |
Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Neuropsychological Tests; Polysomnography; Sleep Initiation and Maintenance Disorders | 2007 |
The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia.
Topics: Adolescent; Adult; Cross-Over Studies; Delta Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Middle Aged; Polysomnography; Pyridines; Sleep; Sleep, REM; Theta Rhythm; Wakefulness; Zolpidem | 2007 |
Short-term treatment with gaboxadol improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomnia.
Topics: Adolescent; Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electroencephalography; GABA Agonists; Headache; Humans; Isoxazoles; Middle Aged; Nausea; Polysomnography; Pyridines; Sex Factors; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tachycardia; Time Factors; Treatment Outcome; Zolpidem | 2007 |
Efficacy of the selective extrasynaptic GABA A agonist, gaboxadol, in a model of transient insomnia: a randomized, controlled clinical trial.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Receptors, GABA; Sleep Initiation and Maintenance Disorders; Wakefulness | 2008 |
Slow wave sleep enhancement with gaboxadol reduces daytime sleepiness during sleep restriction.
Topics: Adult; Affect; Arousal; Attention; Circadian Rhythm; Disorders of Excessive Somnolence; Double-Blind Method; Electroencephalography; Epinephrine; Fatigue; Female; Fourier Analysis; GABA Agonists; Humans; Hydrocortisone; Isoxazoles; Male; Mental Recall; Neuropsychological Tests; Norepinephrine; Polysomnography; Psychomotor Performance; Reaction Time; Sleep; Sleep Deprivation | 2008 |
Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studies.
Topics: Adolescent; Adult; Age Factors; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Young Adult | 2008 |
Next-day residual effects of gaboxadol and flurazepam administered at bedtime: a randomized double-blind study in healthy elderly subjects.
Topics: Administration, Oral; Aged; Cross-Over Studies; Disorders of Excessive Somnolence; Double-Blind Method; Female; Flurazepam; GABA Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Mental Recall; Psychomotor Performance; Reaction Time; Surveys and Questionnaires; Time Factors | 2009 |
Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects.
Topics: Aged; Cross-Over Studies; Double-Blind Method; Female; Flicker Fusion; GABA Agonists; Humans; Isoxazoles; Male; Postural Balance; Pyridines; Reaction Time; Zolpidem | 2009 |
A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Administration Schedule; Electronic Data Processing; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Pyridines; Severity of Illness Index; Single-Blind Method; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Surveys and Questionnaires; Time Factors; Treatment Outcome; Young Adult; Zolpidem | 2009 |
Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep.
Topics: Adolescent; Adult; Cross-Over Studies; Electroencephalography; Female; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Middle Aged; Pyridines; Receptors, GABA-A; Sex Factors; Sleep; Sleep Stages; Sleep, REM; Young Adult; Zolpidem | 2010 |
Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; GABA Agonists; Humans; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Sex Characteristics; Sleep Initiation and Maintenance Disorders | 2010 |
Alterations in cyclic alternating pattern associated with phase advanced sleep are differentially modulated by gaboxadol and zolpidem.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Female; GABA Agonists; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Pyridines; Self Report; Sleep Initiation and Maintenance Disorders; Sleep Stages; Young Adult; Zolpidem | 2010 |
Enhanced slow wave sleep and improved sleep maintenance after gaboxadol administration during seven nights of exposure to a traffic noise model of transient insomnia.
Topics: Adult; Aged; Automobiles; Female; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Middle Aged; Noise, Transportation; Polysomnography; Self Report; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages | 2012 |
EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Sex Distribution; Sleep Initiation and Maintenance Disorders; Time Factors; Young Adult | 2011 |
Combining escitalopram with gaboxadol provides no additional benefit in the treatment of patients with severe major depressive disorder.
Topics: Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; International Cooperation; Isoxazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult | 2012 |
EEG spectral power density profiles during NREM sleep for gaboxadol and zolpidem in patients with primary insomnia.
Topics: Adolescent; Adult; Aged; Brain Waves; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Sedatives; Isoxazoles; Middle Aged; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Zolpidem | 2012 |
Effects of pulvinar inactivation on spatial decision-making between equal and asymmetric reward options.
Topics: Analgesics; Animals; Bias; Contrast Sensitivity; Decision Making; Functional Laterality; Isoxazoles; Macaca mulatta; Magnetic Resonance Imaging; Male; Memory; Movement; Neural Pathways; Reaction Time; Reward; Saccades; Space Perception; Visual Cortex | 2013 |
Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers.
Topics: Adult; Brain; Brain Waves; Cross-Over Studies; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetoencephalography; Male; Nipecotic Acids; Pyridines; Rest; Single-Blind Method; Synapses; Tiagabine; Young Adult; Zolpidem | 2015 |
Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.
Topics: Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult; Zolpidem | 2014 |
The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman Syndrome.
Topics: Adolescent; Adult; Angelman Syndrome; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Young Adult | 2021 |
419 other study(ies) available for isoxazoles and gaboxadol
| Article | Year |
|---|---|
Effects of GABA-mimetic agents on the cat spinal cord.
Topics: Animals; Bicuculline; Cats; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Ibotenic Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neurons, Afferent; Spinal Cord | 1979 |
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug | 1979 |
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord.
Topics: Aminobutyrates; Animals; Biological Transport; Cats; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons; Nipecotic Acids; Oxazoles; Spinal Cord | 1978 |
Muscimol and N,N-dimethylmuscimol: from a GABA agonist to a glycine antagonist.
Topics: Chemical Phenomena; Chemistry, Physical; Computer Simulation; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Structure-Activity Relationship | 1992 |
Defense reaction elicited by microinjection of kainic acid into the medial hypothalamus of the rat: antagonism by a GABAA receptor agonist.
Topics: Agonistic Behavior; Animals; Anticonvulsants; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Exploratory Behavior; Hypothalamus, Middle; Isoxazoles; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Social Isolation | 1992 |
First direct electron microscopic visualization of a tight spatial coupling between GABAA-receptors and voltage-sensitive calcium channels.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calcium Channels; Cells, Cultured; Cerebellar Cortex; Immunohistochemistry; Ion Channel Gating; Isoxazoles; Microscopy, Electron; Neurons; Rats; Receptors, GABA-A | 1992 |
The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Infusions, Parenteral; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Substantia Nigra | 1992 |
Pharmacological study of the chicken's monocular optokinetic nystagmus: effects of GABAergic agonist and antagonists.
Topics: Animals; Bicuculline; Chickens; Electroretinography; Eye Movements; Injections; Isoxazoles; Nystagmus, Optokinetic; Picrotoxin; Receptors, GABA-A; Retina; Vision, Monocular; Visual Pathways | 1992 |
GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.
Topics: Alcohol Drinking; Animals; Baclofen; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Rats; Receptors, GABA-A | 1992 |
Microstructural analysis of the effects of THIP, a GABAA agonist, on voluntary ethanol intake in laboratory rats.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, GABA-A | 1992 |
Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
Topics: Aging; Aminobutyrates; Analgesics; Animals; Baclofen; Bicuculline; Binding, Competitive; Brain; Female; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Male; Muscimol; Receptors, GABA-A; Salmon; Sexual Behavior, Animal | 1992 |
Inhibition of tetrahydroisoxazolo-pyridin-3-ol and muscimol and its mechanism on gastrointestinal transit in mice.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Isoxazoles; Male; Mice; Muscimol; Phentolamine; Propranolol; Yohimbine | 1992 |
Plasticity of the frog monocular OKN: involvement of pretectal GABAergic and cholinergic systems.
Topics: Animals; Atropine; gamma-Aminobutyric Acid; Isoxazoles; Microinjections; Nystagmus, Physiologic; Parasympathetic Nervous System; Rana esculenta; Vision, Monocular | 1992 |
Effect of a GABA agonist on the expression and distribution of GABAA receptors in the plasma membrane of cultured cerebellar granule cells: an immunocytochemical study.
Topics: Animals; Cell Membrane; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Rats; Receptors, GABA-A | 1991 |
Chronic flurazepam differentially regulates a behavioral effect of GABA agonists.
Topics: Animals; Drug Interactions; Flurazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Rotation; Substantia Nigra; Time Factors | 1991 |
Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Electrodes; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoxazoles; Nipecotic Acids; Potassium; Proline; Receptors, GABA-A; Temperature | 1991 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Motor Activity; Nerve Degeneration; Neurons; Nipecotic Acids; Rats; Rats, Inbred Strains; Synaptic Transmission; Tiagabine | 1991 |
GABAergic drugs and conflict behavior in the rat: lack of similarities with the actions of benzodiazepines.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Behavior, Animal; Benzodiazepines; Bicuculline; Brain; Conflict, Psychological; Drug Interactions; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1991 |
Effects of gamma-aminobutyric acid receptor agonists and antagonist on LHRH-synthesizing neurons as detected by immunocytochemistry and in situ hybridization.
Topics: Animals; Baclofen; Bicuculline; Female; GABA-A Receptor Antagonists; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Immunohistochemistry; Isoxazoles; Neurons; Nucleic Acid Hybridization; Ovariectomy; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; RNA Probes; RNA, Messenger | 1991 |
Why are most GABA agonists not effective antiepileptic drugs?
Topics: Animals; Anticonvulsants; Bicuculline; Cats; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Receptors, GABA-A; Synaptic Transmission; Trigeminal Nucleus, Spinal | 1991 |
GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat.
Topics: Analgesics; Anesthesia; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter | 1991 |
Role of calcium in the analgesic action of tetrahydroisoxazolepyridinol and muscimol.
Topics: Analgesics; Animals; Calcium; Calcium Chloride; Isoxazoles; Male; Mice; Morphine; Muscimol; Nifedipine | 1991 |
GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures.
Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Exploratory Behavior; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Social Behavior; Valproic Acid | 1991 |
Glycinergic control of [Leu5]enkephalin levels in chicken retina.
Topics: Animals; Baclofen; Chickens; Enkephalin, Leucine; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Muscimol; Neurotransmitter Agents; Picrotoxin; Radioimmunoassay; Retina; Strychnine | 1991 |
Activation of subconductance states by gamma-aminobutyric acid and its analogs in chick cerebral neurons.
Topics: Analgesics; Animals; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Channels; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons | 1990 |
Tolerance pattern to GABAmimetic analgesics and their influence on morphine tolerance and dependence.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Muscimol; Naloxone; Substance-Related Disorders | 1991 |
Modulation of tolerance to the GABAA agonist THIP by environmental cues.
Topics: Animals; Anticonvulsants; Arousal; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxazoles; Receptors, GABA-A; Social Environment | 1990 |
Stimulation of luteinizing hormone release by gamma-aminobutyric acid (GABA) agonists: mediation by GABAA-type receptors and activation of chloride and voltage-sensitive calcium channels.
Topics: Amino Acid Sequence; Animals; Baclofen; Calcium Channels; Cells, Cultured; Chloride Channels; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Isoxazoles; Luteinizing Hormone; Membrane Proteins; Molecular Sequence Data; Muscimol; Nifedipine; Pituitary Gland, Anterior; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells.
Topics: Animals; Anticonvulsants; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; Colchicine; Cycloheximide; Dactinomycin; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Monensin; Oxazoles; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Neurochemical correlates of gamma-aminobutyrate (GABA) inhibition in cat visual cortex.
Topics: Animals; Baclofen; Calcium; Cats; Cell Membrane; Female; GABA Antagonists; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Neurons; Potassium; Pyridazines; Receptors, GABA-A; Visual Cortex | 1990 |
Involvement of GABA receptors in the regulation of neurite growth in cultured embryonic chick tectum.
Topics: Animals; Axons; Baclofen; Cells, Cultured; Chick Embryo; Culture Media; gamma-Aminobutyric Acid; Isoxazoles; Ligands; Muscimol; Receptors, GABA-A; Superior Colliculi | 1990 |
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Physical Stimulation; Somatosensory Cortex; Synapses | 1990 |
Abolition of monocular optokinetic nystagmus directional asymmetry after unilateral visual deprivation in adult vertebrates: involvement of the GABAergic mechanism.
Topics: Animals; Chickens; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Nystagmus, Physiologic; Rana esculenta; Sensory Deprivation; Visual Pathways | 1990 |
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscimol; Phenobarbital; Receptors, GABA-A; Time Factors | 1988 |
Binding of [3H]-muscimol to GABAA sites in the guinea-pig urinary bladder: biochemical assay and autoradiography.
Topics: Animals; Autoradiography; Bicuculline; Binding, Competitive; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Isoxazoles; Muscimol; Receptors, GABA-A; Tritium; Urinary Bladder | 1989 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
GABAergic drugs and lordosis behavior in the female rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine | 1989 |
Stimulation by phaclofen of inositol 1,4,5-triphosphate production in cultured neurons from chick tectum.
Topics: Animals; Baclofen; Chick Embryo; gamma-Aminobutyric Acid; Inosine Nucleotides; Inosine Triphosphate; Isoxazoles; Neurons; Receptors, GABA-A; Superior Colliculi | 1989 |
Ionic mechanisms of action of GABA on dorsal and ventral root myelinated fibers: effects of K+ channel blockers.
Topics: 4-Aminopyridine; Animals; Barium; Barium Compounds; Cesium; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Neurons; Neurons, Afferent; Potassium; Potassium Channels; Rana catesbeiana; Tetraethylammonium Compounds | 1989 |
Late inhibitory postsynaptic potentials in rat prefrontal cortex may be mediated by GABAB receptors.
Topics: Animals; Baclofen; Electric Conductivity; Electric Stimulation; Evoked Potentials; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoxazoles; Male; Membrane Potentials; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Synapses | 1989 |
Role of GABAergic system in prolactin analgesia.
Topics: Analgesics; Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Prolactin | 1989 |
Enzymic synthesis of two glucuronides of the hydroxyisoxazole GABA-agonist, THIP, and the in vivo glucuronidation of THIP in rat.
Topics: Animals; Chromatography, High Pressure Liquid; Glucuronates; Glucuronidase; Hydrolysis; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxazoles; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1989 |
Baclofen-induced, calcium-dependent stimulation of in vivo release of D-[3H]aspartate from rat hippocampus monitored by intracerebral microdialysis.
Topics: Animals; Aspartic Acid; Baclofen; Calcium; GABA Antagonists; Hippocampus; Ischemic Attack, Transient; Isoxazoles; Male; Potassium; Rats; Rats, Inbred Strains | 1989 |
Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots.
Topics: Anesthetics; Animals; Axons; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Myelin Sheath; Oxazoles; Potassium; Rana catesbeiana; Spinal Cord | 1989 |
GABA-benzodiazepine modulation of aversion in the medial hypothalamus of the rat.
Topics: Animals; Avoidance Learning; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Flumazenil; Hypothalamus, Middle; Isoxazoles; Male; Microinjections; Midazolam; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland.
Topics: Adrenal Medulla; Analgesics; Animals; Bicuculline; Catecholamines; Dogs; Electric Stimulation; Enkephalins; Female; Isoxazoles; Oxazoles; Receptors, GABA-A; Splanchnic Nerves | 1987 |
Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.
Topics: Action Potentials; Adenylate Cyclase Toxin; Animals; Baclofen; Hippocampus; In Vitro Techniques; Isoxazoles; Neural Conduction; Neural Inhibition; Pertussis Toxin; Rats; Receptors, GABA-A; Virulence Factors, Bordetella | 1987 |
Structural factors governing agonist and antagonist activity in the GABAA system.
Topics: Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Receptors, GABA-A; Structure-Activity Relationship | 1988 |
3- and 5-isoxazolol zwitterions: an ab initio molecular orbital study relating to GABA agonism and antagonism.
Topics: Chemical Phenomena; Chemistry; Crotonates; GABA Antagonists; Isoxazoles; Molecular Conformation; Muscimol; Pyridines; Receptors, GABA-A | 1987 |
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus.
Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus | 1988 |
GABA-related drugs modulate the behavioral effects of lorazepam.
Topics: Animals; Behavior, Animal; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Lorazepam; Male; Oxazoles; Receptors, GABA-A; Saimiri | 1988 |
Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors | 1987 |
GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development.
Topics: Animals; Cells, Cultured; Cerebellar Cortex; Isoxazoles; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
Inhibition of sexual reflexes by lumbosacral injection of a GABAB agonist in the male rat.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Spinal; Isoxazoles; Lumbosacral Region; Male; Penile Erection; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Spinal Cord | 1988 |
The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs.
Topics: Acetylcholine; Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Ethanolamines; Female; gamma-Aminobutyric Acid; Guinea Pigs; Isoxazoles; Male; Muscimol; Serotonin Antagonists | 1985 |
Quantitative electrocortical changes in the rat induced by phencyclidine and other stimulants.
Topics: Animals; Apomorphine; Baclofen; Cerebral Cortex; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Dioxolanes; Electroencephalography; Isoquinolines; Isoxazoles; Male; Muscimol; Phencyclidine; Rats; Rats, Inbred Strains | 1985 |
Excitatory amino acids: studies on the biochemical and chemical stability of ibotenic acid and related compounds.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Decarboxylation; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Ibotenic Acid; Isoxazoles; Liver; Mice; Muscimol; Oxazoles; Pregnancy Proteins | 1985 |
Discriminative stimulus effects of atypical anxiolytics in baboons and rats.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepinones; Buspirone; Discrimination Learning; Flumazenil; Isoxazoles; Lorazepam; Male; Papio; Piperazines; Pyrazoles; Pyridazines; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Intrinsic gamma aminobutyric acid receptors modulate the release of catecholamine from canine adrenal gland in situ.
Topics: Adrenal Medulla; Animals; Baclofen; Bicuculline; Chromaffin Granules; Dogs; Electric Stimulation; Epinephrine; Female; Hexamethonium; Hexamethonium Compounds; Histocytochemistry; Isoxazoles; Muscimol; Naloxone; Norepinephrine; Receptors, GABA-A; Splanchnic Nerves | 1986 |
Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.
Topics: Analgesics; Animals; Baclofen; Desipramine; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Antipsychotic Agents; Cebus; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Vigabatrin | 1988 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex.
Topics: Acetylcholine; Animals; Atropine; Baclofen; Benzodiazepinones; Clonazepam; Corpus Striatum; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine | 1985 |
Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Blood Pressure; Carbolines; Clonidine; Cyproheptadine; Diazepam; Epinephrine; Heart Rate; Humans; Hydrocortisone; Indoles; Isoxazoles; Macaca mulatta; Male; Norepinephrine; Propranolol | 1985 |
Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Synergism; Electroshock; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Nervous System; Receptors, GABA-A | 1985 |
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Oxazoles; Postural Balance; Receptors, GABA-A | 1985 |
Parallel changes in the sensitivity of gamma-aminobutyric acid and noradrenergic receptors following chronic administration of antidepressant and GABAergic drugs. A possible role in affective disorders.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Baclofen; Cerebral Cortex; Dihydroalprenolol; gamma-Aminobutyric Acid; Hippocampus; Humans; Imipramine; Isoxazoles; Kinetics; Male; Mice; Mood Disorders; Nomifensine; Receptors, Adrenergic; Receptors, GABA-A | 1985 |
GABAergic drugs and sexual behaviour in the male rat.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1985 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, Neurologic; Muscimol; Muscle Relaxation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analogue of the GABA agonist THIP.
Topics: Animals; Anticonvulsants; Cerebellum; Electrophysiology; Female; Isoxazoles; Male; Mice; Muscimol; Oxazoles; Rats; Receptors, GABA-A | 1985 |
Diazepam antagonizes GABAmimetics in rats with spontaneous petit mal-like epilepsy.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Cycloserine; Diazepam; Epilepsy, Absence; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vigabatrin | 1985 |
GABAergic effects of reserpine following chronic treatment.
Topics: Animals; Baclofen; Binding, Competitive; Cerebral Cortex; Dihydroalprenolol; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Isoxazoles; Male; Mice; Receptors, GABA-A; Reserpine | 1985 |
The locomotor-reducing effects of GABAergic drugs do not depend on the GABAA receptor.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taurine | 1985 |
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Topics: Animals; Bicuculline; Brain; Cats; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Oxazolidinones; Piperidines; Rats; Receptors, GABA-A; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1985 |
GABAergic involvement in the antinociceptive effects of morphine at the level of the periaqueductal gray matter in the rat.
Topics: Animals; Isoxazoles; Male; Morphine; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.
Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1985 |
Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray.
Topics: Animals; Behavior, Animal; Bicuculline; Escape Reaction; Hypothalamus, Middle; Isoxazoles; Male; Mesencephalon; Microinjections; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Superior Colliculi | 1985 |
Autoradiographic localization of binding sites for the gamma-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord.
Topics: Animals; Animals, Newborn; Autoradiography; Baclofen; Binding Sites; Cells, Cultured; Cerebellum; Fetus; Isonicotinic Acids; Isoxazoles; Oxazoles; Rats; Receptors, GABA-A; Spinal Cord | 1985 |
GABAB receptor-mediated enhancement of vasoactive intestinal peptide-stimulated cyclic AMP production in slices of rat cerebral cortex.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Baclofen; Bicuculline; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasoactive Intestinal Peptide | 1986 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures | 1986 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Receptors, GABA-A; Seizures | 1986 |
gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Baclofen; Bicuculline; Brain; Cell Membrane; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Liver; Male; Mice; Mice, Inbred DBA; Muscimol; Picrotoxin; Receptors, GABA-A; Sodium; Sulfates; Taurine; Temperature | 1986 |
Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
Topics: Aggression; Aminocaproates; Animals; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Motor Activity; Muscimol; Nipecotic Acids; Olfactory Bulb; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission; Valproic Acid; Vigabatrin | 1986 |
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Intracellular Membranes; Isoxazoles; Kinetics; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Glycine antagonists structurally related to 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol inhibit binding of [3H]strychnine to rat brain membranes.
Topics: Animals; Anions; Binding, Competitive; Cell Membrane; Chlorides; Choline; GABA Antagonists; Glycine; Isoxazoles; Male; Medulla Oblongata; Oxazoles; Pons; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Sodium Chloride; Strychnine | 1986 |
The parafasciculus thalami as a site for mediating the antinociceptive response to GABAergic drugs.
Topics: Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Synaptic Transmission; Thalamic Nuclei | 1986 |
[Changes in the ligand affinity of benzodiazepine receptors in the presence of 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP)].
Topics: Animals; Brain; Depression, Chemical; Dose-Response Relationship, Drug; Flunitrazepam; In Vitro Techniques; Isoxazoles; Ligands; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA.
Topics: Animals; Avoidance Learning; Baclofen; Electrodes, Implanted; gamma-Aminobutyric Acid; Isoxazoles; Male; Mesencephalon; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Hypnotic action of pentobarbital in mice: a possible mechanism.
Topics: Animals; Baclofen; Bicuculline; Isoxazoles; Male; Mice; Oxazoles; Pentobarbital; Receptors, GABA-A; Reflex; Sleep | 1987 |
Effects of GABAergic drugs on the GABA turnover in the substantia nigra and the corpus striatum of the rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Corpus Striatum; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1987 |
[Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam].
Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrazoles; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Tranquilizing Agents | 1987 |
Cardiorespiratory effects produced by injecting drugs that affect GABA receptors into nuclei associated with the ventral surface of the medulla.
Topics: Animals; Bicuculline; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Muscimol; Respiration; Synaptic Transmission | 1987 |
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission | 1987 |
Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat.
Topics: Animals; Baclofen; Bicuculline; Cats; Female; Heart; Injections, Intravenous; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, GABA-A; Respiration | 1987 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid | 1986 |
Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons.
Topics: Adenylate Cyclase Toxin; Animals; Baclofen; Brain; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neural Inhibition; Neurons; Pertussis Toxin; Rats; Synapses; Thionucleotides; Time Factors; Virulence Factors, Bordetella | 1988 |
Inducing anesthesia with a GABA analog, THIP.
Topics: Analgesics; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; gamma-Aminobutyric Acid; Isoxazoles; Ketamine; Male; Mice; Midazolam; Oxazoles; Rats; Rats, Inbred Strains; Sodium Oxybate; Time Factors | 1985 |
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine.
Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Body Temperature; Desipramine; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains | 1988 |
The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance.
Topics: Adolescent; Adult; Behavior; Carotid Arteries; Cerebrovascular Circulation; Dominance, Cerebral; Electroencephalography; gamma-Aminobutyric Acid; Humans; Injections, Intra-Arterial; Isoxazoles; Middle Aged; Neural Inhibition; Oxazoles; Synapses | 1988 |
Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasm; Endoplasmic Reticulum; gamma-Aminobutyric Acid; Golgi Apparatus; Isoxazoles; Microscopy, Electron; Oxazoles; Rats; Rats, Inbred Strains | 1988 |
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1988 |
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Periaqueductal Gray; Picrotoxin; Raphe Nuclei; Rats; Rats, Inbred Strains | 1987 |
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Motor Activity; Pain; Pyrans; Pyrones | 1987 |
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium | 1987 |
Intrathecal administration of pentobarbital and THIP: evidence for descending excitatory and inhibitory modulation of a spinal reflex.
Topics: Analgesics; Animals; Efferent Pathways; Injections, Spinal; Isoxazoles; Male; Neural Inhibition; Oxazoles; Pentobarbital; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1987 |
Effect of repeated treatment with a gamma-aminobutyric acid receptor agonist on postnatal neural development in rats.
Topics: Animals; Antigens, Surface; Brain; Cell Adhesion; Cell Adhesion Molecules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Isoxazoles; Nerve Tissue Proteins; Neurons; Organ Size; Oxazoles; Rats; Rats, Inbred Strains | 1987 |
Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Histamine; Isoxazoles; Male; Methylhistamines; Methylhistidines; Mice; Muscimol | 1986 |
The effect of diazepam upon local cerebral glucose use in the conscious rat.
Topics: Animals; Autoradiography; Brain Chemistry; Deoxy Sugars; Deoxyglucose; Diazepam; Energy Metabolism; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains | 1986 |
GABA-mimetic drugs enhance apomorphine-induced contralateral turning in rats with unilateral nigrostriatal dopamine denervation: implications for the therapy of Parkinson's disease.
Topics: Alkynes; Aminocaproates; Animals; Antiparkinson Agents; Apomorphine; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Parkinson Disease; Rats; Rats, Inbred Strains | 1987 |
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine | 1985 |
Blockade of "antiabsence" activity of sodium valproate by THIP in rats with petit mal-like seizures. Comparison with ethosuximide.
Topics: Animals; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Injections; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Subchronic administration of GABAergic agonists elevates [3H]GABA binding and produces tolerance in striatal dopamine catabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrones; Rats; Rats, Inbred Strains; Vigabatrin | 1985 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1985 |
Shock titration in the rhesus monkey: effects of opiate and nonopiate analgesics.
Topics: Administration, Oral; Analgesics; Animals; Aspirin; Codeine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Ibuprofen; Injections, Intramuscular; Isoxazoles; Male; Morphine; Narcotics; Reaction Time; Sensory Thresholds; Time Factors | 1985 |
GABAergic mechanisms in antinociception.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin | 1984 |
Somatic and dendritic actions of gamma-aminobutyric acid agonists and uptake blockers in the hippocampus in vivo.
Topics: Acetylcholine; Action Potentials; Animals; Dendrites; gamma-Aminobutyric Acid; Hippocampus; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Synaptic Transmission | 1984 |
GABAergic agents as anticonvulsants in baboons with photosensitive epilepsy.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Carbolines; Cerebral Cortex; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Papio; Photic Stimulation; Receptors, Cell Surface; Receptors, GABA-A; Taurine; Vigabatrin | 1984 |
Pretreatment with GABA and modulatory ligands enhances GABA receptor binding.
Topics: Animals; Baclofen; Binding Sites; Cerebral Cortex; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1984 |
Involvement of central GABAergic receptors in the control over offensive and defensive behaviours in the rat.
Topics: Aggression; Animals; Bicuculline; Electroshock; Humans; Injections, Intraventricular; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds | 1984 |
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A | 1984 |
Differential reversal by scopolamine and THIP of the antistereotypic and cataleptic effects of neuroleptics.
Topics: Amphetamine; Animals; Antipsychotic Agents; Catalepsy; Humans; Isoxazoles; Male; Oxazoles; Rats; Scopolamine; Stereotyped Behavior | 1981 |
Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Binding Sites; Cerebellum; Chlorides; Etazolate; Flunitrazepam; Isoxazoles; Male; Muscimol; Nicotinic Acids; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium | 1981 |
Stimulated release of 3H-glycine from retina.
Topics: Animals; Aporphines; Aspartic Acid; Cysteic Acid; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Muscimol; Rabbits; Retina | 1982 |
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Time Factors | 1982 |
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium | 1980 |
Cardiovascular effects of THIP in the rat.
Topics: Animals; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoxazoles; Muscimol; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Therapeutic failure of GABA agonist treatment in Huntington's disease.
Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles | 1984 |
Multiple benzodiazepine receptor complexes: some benzodiazepine recognition sites are coupled to GABA receptors and ionophores.
Topics: Animals; Anions; Benzodiazepines; Bicuculline; Brain; Buffers; Flunitrazepam; gamma-Aminobutyric Acid; Haplorhini; Hot Temperature; Ionophores; Isonicotinic Acids; Isoxazoles; Macromolecular Substances; Papio; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1980 |
Heterogeneous depression of glucose utilization in the caudate nucleus by GABA agonists.
Topics: Animals; Autoradiography; Blood Glucose; Caudate Nucleus; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
Role of GABA-ergic receptors for the synthesis of GABA in different compartments of the rat cerebellum.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
The binding of the GABA agonist [3H]THIP to rat brain synaptic membranes.
Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Tritium | 1982 |
Orally administered THIP inhibits food intake in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Dose-Response Relationship, Drug; Eating; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
THIP inhibits feeding behavior in fasted rats.
Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Eating; Food Deprivation; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Corpus Striatum; Diazepam; Dopamine; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Neural Pathways; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substantia Nigra | 1982 |
Central cardiovascular effects produced by the GABA receptor agonist drug, THIP.
Topics: Animals; Autonomic Nervous System; Bicuculline; Blood Pressure; Brain; Cats; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
Topics: Animals; Cats; gamma-Aminobutyric Acid; Glycine; Interneurons; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Structure-Activity Relationship | 1982 |
Autoreceptors modify the evoked release of [3H]GABA from cerebellar neurons in dissociated cell culture.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Fluspirilene; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Neurons; Potassium; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
GABAergic modulation of ethanol-induced motor impairment.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminobutyrates; Aminocaproates; Animals; Bicuculline; Brain; Ethanol; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Skills; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
gamma-aminobutyric acid receptors modulate cation binding sites coupled to independent benzodiazepine, picrotoxin, and anion binding sites.
Topics: Animals; Binding Sites; Brain; Calcium Chloride; Electrolytes; Flunitrazepam; In Vitro Techniques; Isoxazoles; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Sodium Chloride | 1982 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
The acute effect of the GABA-agonist, THIP, on proprioceptive and flexor reflexes in spastic patients.
Topics: Adult; Female; Humans; Isoxazoles; Male; Mechanoreceptors; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Oxazoles; Paraplegia; Proprioception; Reaction Time; Receptors, Cell Surface; Receptors, GABA-A; Reflex, Monosynaptic; Reflex, Stretch | 1983 |
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes | 1983 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disease Susceptibility; Ethanol; Forelimb; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Tremor | 1983 |
GABA as a trophic factor during development.
Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Nipecotic Acids; Proline; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Retina | 1983 |
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes.
Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Comparison of GABA analogues at the crayfish stretch receptor neurone.
Topics: Animals; Astacoidea; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Isoxazoles; Mechanoreceptors; Membrane Potentials; Muscimol; Nipecotic Acids; Proline; Sodium | 1983 |
Benzodiazepine receptor mediated discriminative cues: effects of GABA-ergic drugs and inverse agonists.
Topics: Animals; Cues; Diazepam; Discrimination Learning; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Antinociceptive effect of the GABAmimetic 4,5,6,7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP): chronic treatment increases alpha-2 adrenoceptors in the mouse brain.
Topics: Analgesics; Animals; Brain Chemistry; Clonidine; Drug Tolerance; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Diazotization and thiocyanate differentiate agonists from antagonists for the high- and low-affinity receptors of gamma-aminobutyric acid.
Topics: Androstanes; Animals; Azasteroids; Benzenesulfonates; Bicuculline; Cerebral Cortex; Diazonium Compounds; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids; Thiocyanates; Tubocurarine | 1984 |
Pharmacological analysis of the central cardiovascular effects of four GABA analogues.
Topics: Animals; Atropine; Bicuculline; Blood Pressure; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Isonicotinic Acids; Isoxazoles; Kainic Acid; Muscimol; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Microiontophoretically applied THIP effects upon nociceptive responses of neurons in medial thalamus.
Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinothalamic Tracts; Synaptic Transmission; Tail; Thalamic Nuclei | 1983 |
Effect of apomorphine and gabaergic drugs in monkeys pretreated with haloperidol.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Apomorphine; Chlorocebus aethiops; Female; gamma-Aminobutyric Acid; Haloperidol; Hemodynamics; Isoxazoles; Male; Motor Activity; Muscimol; Picrotoxin | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid | 1983 |
Effects of THIP on chronic anxiety.
Topics: Adult; Anxiety Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Psychiatric Status Rating Scales | 1983 |
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia.
Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced | 1984 |
Gabaergic modulation of mouse-killing in the rat.
Topics: Aggression; Aminocaproates; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nipecotic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid; Vigabatrin | 1984 |
Flight induced by infusion of bicuculline methiodide into periventricular structures.
Topics: Animals; Bicuculline; Brain Mapping; Escape Reaction; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus, Middle; Isoxazoles; Male; Motor Activity; Periaqueductal Gray; Rats; Rats, Inbred Strains | 1984 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Penicillins; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Taurine; Time Factors | 1984 |
Self-injurious behavior in rats produced by intranigral microinjection of GABA agonists.
Topics: Animals; Baclofen; Bicuculline; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Inbred Strains; Self Mutilation; Stress, Physiological; Substantia Nigra | 1984 |
Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold.
Topics: Animals; Baclofen; Injections, Spinal; Isoxazoles; Male; Muscimol; Muscle Hypotonia; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1984 |
The influence of GABAergic drugs on PGO activity in the cat.
Topics: Alkynes; Aminocaproates; Animals; Brain; Cats; Chlordiazepoxide; Electroencephalography; Female; gamma-Aminobutyric Acid; Geniculate Bodies; Isoxazoles; Male; Muscimol; Occipital Lobe; Pons | 1983 |
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation.
Topics: Analgesics; Animals; Baclofen; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Motor Activity; Muscimol; Oxazoles; Physical Stimulation; Rats; Rats, Inbred Strains; Superior Colliculi; Touch | 1983 |
Anorexic and analgesic actions of THIP.
Topics: Analgesics; Animals; Appetite Depressants; Behavior, Animal; Benzoquinones; Drug Interactions; Feeding Behavior; Isoxazoles; Male; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time | 1983 |
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain | 1983 |
Pharmacokinetics of the gamma-aminobutyric acid agonist THIP (Gaboxadol) following intramuscular administration to man, with observations in dog.
Topics: Absorption; Adult; Animals; Dogs; Humans; Injections, Intramuscular; Isoxazoles; Kinetics; Male; Models, Biological; Oxazoles | 1983 |
Comparison of the analgesic actions of THIP and morphine.
Topics: Analgesics; Animals; Atropine; Benzoquinones; Bicuculline; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Morphine; Naloxone; Oxazoles; Quinones; Reaction Time | 1983 |
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist.
Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time | 1983 |
State of DA/ACh balance after chronic treatment with haloperidol and with THIP in rats.
Topics: Acetylcholine; Animals; Apomorphine; Atropine; Behavior, Animal; Brain; Dopamine; Haloperidol; Isoxazoles; Male; Oxazoles; Physostigmine; Rats; Rats, Inbred Strains | 1984 |
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neurons; Rabbits; Synapses | 1984 |
Diazepam enhances the action but not the binding of the GABA analog, THIP.
Topics: Animals; Brain; Chlorides; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Spinal; Isoxazoles; Membrane Potentials; Mice; Oxazoles; Rats; Spinal Cord | 1984 |
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors | 1980 |
Nigral actions of GABA agonists are enhanced by chronic fluphenazine and differentiated by concomitant flurazepam.
Topics: Animals; Baclofen; Bicuculline; Female; Fluphenazine; Flurazepam; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1982 |
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds | 1983 |
THIP analgesia: cross tolerance with morphine.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Models, Biological; Morphine; Nipecotic Acids; Oxazoles; Pyrones | 1983 |
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212).
Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors | 1983 |
Quantitative determination of the gamma-aminobutyric acid agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, in serum by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Oxazoles; Papio; Rats; Spectrophotometry, Ultraviolet | 1983 |
Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation.
Topics: Analgesics; Animals; Brain; Deoxy Sugars; Deoxyglucose; gamma-Aminobutyric Acid; Glycolysis; Isoxazoles; Male; Muscimol; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains | 1982 |
Effects of GABA analogues and their interactions with morphine on locomotor activity in two inbred strains of mice.
Topics: Animals; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Muscimol; Piracetam | 1982 |
Differentiation of the analgesic effects of THIP and morphine using three mouse strains.
Topics: Analgesics; Animals; GABA Antagonists; Hot Temperature; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles | 1982 |
Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro.
Topics: Animals; Bicuculline; Dendrites; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Penicillins; Pentobarbital; Pyramidal Tracts; Rats; Receptors, Drug | 1982 |
Comparison of the antinociceptive actions of THIP and morphine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Reaction Time; Species Specificity | 1982 |
Antinociceptive and anticonvulsive effect of THIP, a pure GABA agonist.
Topics: Analgesics; Animals; Anticonvulsants; Benzoquinones; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time | 1982 |
Analgesic properties of the GABA-mimetic THIP.
Topics: Analgesics; Animals; Arthritis, Experimental; Baclofen; Electric Stimulation; Isoxazoles; Macaca mulatta; Mice; Morphine; Muscimol; Oxazoles; Reaction Time | 1981 |
Increases and decreases in local cerebral glucose utilization in response to GABA agonists.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glucose; Isoxazoles; Male; Muscimol; Oxazoles; Rats | 1981 |
GABA in the entopeduncular nucleus and the subthalamic nucleus participates in mediating dopaminergic striatal output functions.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Mesencephalon; Muscimol; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Thalamic Nuclei | 1981 |
Etomidate stereospecifically stimulates forebrain, but not cerebellar, 3H-diazepam binding.
Topics: Animals; Brain; Cerebellum; Diazepam; Etomidate; Female; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereoisomerism; Synaptic Membranes | 1981 |
Paradoxical blockade of a muscimol response by THIP, a GABA agonist and also by GABA-transaminase inhibitors.
Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Myoclonus; Oxazoles; Time Factors; Transaminases | 1981 |
Preliminary studies on the absorption, distribution, metabolism, and excretion of THIP in animal and man using 14C-labelled compound.
Topics: Absorption; Adult; Animals; Brain; Carbon Radioisotopes; Chromatography, Thin Layer; Half-Life; Humans; Hydrolysis; Isoxazoles; Male; Mice; Mice, Inbred Strains; Middle Aged; Oxazoles; Rats; Rats, Inbred Strains; Tissue Distribution | 1981 |
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Motor Activity; Muscimol; Pain; Phencyclidine; Reflex | 1980 |
GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA.
Topics: Animals; Binding Sites; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Oxazoles; Rats; Substantia Nigra | 1980 |
Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Injections, Intravenous; Isoxazoles; Limbic System; Muscimol; Neurons; Rats | 1980 |
Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Benzodiazepines; Binding Sites; Binding, Competitive; Blotting, Western; Cattle; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Macromolecular Substances; Molecular Sequence Data; Muscimol; Precipitin Tests; Rabbits; Rats; Receptors, GABA-A; Sensitivity and Specificity; Sequence Homology, Amino Acid; Tritium | 1995 |
Differential distribution of GABAA receptor subunits in soma and processes of cerebellar granule cells: effects of maturation and a GABA agonist.
Topics: Animals; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; GABA Agonists; GABA-A Receptor Agonists; Immunohistochemistry; Isoxazoles; Microscopy, Immunoelectron; Neurons; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1995 |
Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.
Topics: Animals; Cells, Cultured; Cerebral Cortex; GABA-A Receptor Agonists; Isoxazoles; Magnetic Resonance Spectroscopy; Mice; Neurons; Rats; Rats, Sprague-Dawley | 1995 |
omega-Conotoxin binding sites and regulation of transmitter release in cerebellar granule neurons.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cations, Divalent; Cell Membrane; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GABA Agonists; Hot Temperature; Isoxazoles; Kinetics; Neurons; omega-Conotoxins; Peptides; Potassium Chloride; Prosencephalon; Rats | 1994 |
Role of GABAB receptors in intracellular Ca2+ homeostasis and possible interaction between GABAA and GABAB receptors in regulation of transmitter release in cerebellar granule neurons.
Topics: Animals; Aspartic Acid; Baclofen; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; GABA Agonists; GTP-Binding Proteins; Homeostasis; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Neurotransmitter Agents; Pertussis Toxin; Receptors, GABA-A; Receptors, GABA-B; Virulence Factors, Bordetella | 1994 |
Induction of low-affinity GABAA receptors by the GABA-agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in cultured rat cerebellar granule cells is prevented by inhibition of polyamine biosynthesis.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Cerebellum; Eflornithine; GABA Agonists; Isoxazoles; Kinetics; Membranes; Neurons; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, GABA-A; Spermidine | 1994 |
Extrasynaptic effects of GABA (gamma-aminobutyric acid) agonists on myelinated axons of peripheral nerve.
Topics: Action Potentials; Animals; Axons; Baclofen; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Nerve Fibers, Myelinated; Peripheral Nerves; Rana catesbeiana; Ranidae; Sciatic Nerve; Spinal Nerve Roots; Synapses | 1994 |
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.
Topics: Animals; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Oocytes; Oxazolidinones; Piperidines; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1994 |
Stimulation or blockade of the dorsal nucleus of the lateral lemniscus alters binaural and tonic inhibition in contralateral inferior colliculus neurons.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Electric Stimulation; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Lidocaine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA; Spiral Ganglion | 1993 |
GABA alters GABAA receptor mRNAs and increases ligand binding.
Topics: Animals; Anticonvulsants; Base Sequence; Bicuculline; Cells, Cultured; Cerebellum; DNA Primers; gamma-Aminobutyric Acid; Gene Expression; Isoxazoles; Macromolecular Substances; Molecular Sequence Data; Muscimol; Neurons; Polymerase Chain Reaction; Rats; Receptors, GABA-A; RNA, Messenger | 1993 |
Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats.
Topics: Alcohol Drinking; Animals; Appetite Depressants; Body Weight; Chloride Channels; GABA-A Receptor Antagonists; Isoxazoles; Male; Picrotoxin; Rats; Receptors, GABA-A; Self Administration | 1993 |
Conformational analysis and molecular modelling of a partial GABAA agonist and a glycine antagonist related to the GABAA agonist, THIP.
Topics: Analgesics; Glycine; Isoxazoles; Models, Molecular; Molecular Conformation; Receptors, GABA; Stereoisomerism; Structure-Activity Relationship | 1993 |
gamma-Aminobutyric acid-A (GABAA) agonists down-regulate GABAA/benzodiazepine receptor polypeptides from the surface of chick cortical neurons.
Topics: Androstanes; Animals; Azasteroids; Blotting, Western; Cells, Cultured; Cerebral Cortex; Chick Embryo; Down-Regulation; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Molecular Weight; Neurons; Receptors, GABA-A | 1994 |
GABA, THIP and baclofen inhibition of Purkinje cells and cerebellar nuclei neurons.
Topics: Animals; Baclofen; Cerebellar Nuclei; Dose-Response Relationship, Drug; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Neural Inhibition; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley | 1993 |
A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin.
Topics: Analgesics; Animals; Flavonoids; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Pain Measurement; Parasympathetic Nervous System; Parasympathomimetics | 1993 |
Depletion of polyamines prevents the neurotrophic activity of the GABA-agonist THIP in cultured rat cerebellar granule cells.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Cerebellum; Eflornithine; Isoxazoles; Microscopy, Electron; Ornithine Decarboxylase Inhibitors; Rats; Rats, Sprague-Dawley | 1993 |
Reduced function of gamma-aminobutyric acidA receptors in tottering mouse brain: role of cAMP-dependent protein kinase.
Topics: Animals; Brain Chemistry; Chloride Channels; Chlorine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isoquinolines; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Protein Kinase Inhibitors; Radioisotopes; Receptors, GABA-A; Sulfonamides | 1995 |
Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei.
Topics: Animals; Cerebellum; Enzyme Inhibitors; Evoked Potentials; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Long-Term Potentiation; Male; Marine Toxins; Microcystins; Neurons; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
The GABAA agonist THIP (gaboxadol) increases non-REM sleep and enhances delta activity in the rat.
Topics: Animals; Delta Rhythm; Electroencephalography; Electromyography; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Sleep Stages; Sleep, REM; Wakefulness | 1996 |
pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor.
Topics: Acrylates; Animals; Drosophila melanogaster; Female; GABA Agonists; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Isoxazoles; Oocytes; Receptors, GABA; Recombinant Proteins; Xenopus | 1996 |
N-ethylmaleimide blocks depolarization-induced suppression of inhibition and enhances GABA release in the rat hippocampal slice in vitro.
Topics: Analysis of Variance; Animals; Baclofen; Ethylmaleimide; Evoked Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA | 1997 |
Neuronal regulation of astrocyte morphology in vitro is mediated by GABAergic signaling.
Topics: Animals; Animals, Newborn; Astrocytes; Baclofen; Bicuculline; Cell Adhesion; Cells, Cultured; Coculture Techniques; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Isoxazoles; Muscimol; Neurons; Rats; Rats, Wistar; Signal Transduction; Sodium Channel Blockers; Tetrodotoxin; Time Factors | 1997 |
GABAergic drugs and socio-sexual behavior.
Topics: Animals; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Rats; Rats, Wistar; Sexual Behavior, Animal; Social Behavior; Valproic Acid | 1997 |
Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.
Topics: Animals; Binding, Competitive; DNA, Complementary; Electrophysiology; GABA Agonists; GABA Antagonists; Humans; Isoxazoles; Kinetics; Macromolecular Substances; Muscimol; Oocytes; Piperidines; Receptors, GABA-A; Transduction, Genetic; Transfection; Tritium; Xenopus laevis | 1997 |
THIP, a selective gamma-aminobutyric acid receptor agonist, alters flash-evoked potentials in rats.
Topics: Animals; Body Temperature; Electrophysiology; Evoked Potentials, Visual; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Photic Stimulation; Rats; Superior Colliculi; Visual Cortex | 1997 |
gamma-Aminobutyric acidA agonists differentially augment gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice.
Topics: Animals; Behavior, Animal; Benzazepines; Cocaine; Dopamine Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Piperazines | 1998 |
Neurosteroid inhibition of cell death.
Topics: Alkaloids; Animals; Antimycin A; Benzylisoquinolines; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Dehydroepiandrosterone Sulfate; Female; gamma-Aminobutyric Acid; Isoxazoles; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Mitochondria; Muscimol; Oxygen Consumption; Pregnanes; Rabbits; Receptors, GABA-A | 1997 |
Expression of the GABA(A) receptor alpha6 subunit in cultured cerebellar granule cells is developmentally regulated by activation of GABA(A) receptors.
Topics: Animals; Cells, Cultured; Cerebellum; GABA Agonists; Gene Expression Regulation, Developmental; Isoxazoles; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
The GABA(A) agonist THIP increases non-REM sleep and enhances non-REM sleep-specific delta activity in the rat during the dark period.
Topics: Animals; Circadian Rhythm; Delta Rhythm; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; GABA Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Sleep, REM; Wakefulness | 1997 |
[Receptor mechanism of the neuroprotective effect of GABAergic agents].
Topics: Animals; Baclofen; Brain Ischemia; Female; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Injections, Subcutaneous; Isonipecotic Acids; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscimol; Neuroprotective Agents; Receptors, GABA-A; Receptors, GABA-B | 1998 |
Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hexachlorocyclohexane; Insecticides; Isoxazoles; Mice; Mitochondria; Neurons; Synaptic Transmission; Tetrazolium Salts; Thiazoles | 1998 |
The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine.
Topics: Amphetamine; Animals; Bicuculline; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Frontal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Models, Neurological; Motor Activity; Stereotyped Behavior; Sulpiride | 1998 |
Effects of the GABA agonists baclofen and THIP on long-term compensation in hemilabyrinthectomised rats.
Topics: Animals; Baclofen; Ear, Inner; Eye Movements; Functional Laterality; GABA Agonists; Isoxazoles; Magnetics; Nystagmus, Pathologic; Rats; Rats, Inbred Strains; Reflex, Vestibulo-Ocular | 1998 |
GABAergic drugs and sexual behaviour in the rabbit: evidence for species-specific effects.
Topics: Animals; Baclofen; Bicuculline; Copulation; Dose-Response Relationship, Drug; Escape Reaction; GABA Agents; Isoxazoles; Male; Picrotoxin; Rabbits; Rats; Sexual Behavior, Animal; Species Specificity; Structure-Activity Relationship | 1998 |
Defining affinity with the GABAA receptor.
Topics: Animals; Animals, Newborn; beta-Alanine; Cells, Cultured; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Ligands; Muscimol; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Receptors, GABA-A | 1998 |
Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice.
Topics: Analysis of Variance; Animals; Baclofen; Central Nervous System Stimulants; Ethanol; GABA Agonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Isoxazoles; Mice; Mice, Inbred DBA; Motor Activity; Receptors, GABA-A; Receptors, GABA-B | 1999 |
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A | 1999 |
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Isoxazoles; Male; Microinjections; Naloxone; Narcotic Antagonists; Nerve Net; Periaqueductal Gray; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Seizures | 1999 |
GABA agonists differentially modify blood glucose levels of diabetic rats.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Benzodiazepines; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Female; GABA Agonists; Insulin; Isoxazoles; Rats; Rats, Wistar | 1999 |
Channel properties determine the transient activation kinetics of recombinant GABA(A) receptors.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Membrane Potentials; Protein Isoforms; Receptors, GABA-A; Recombinant Fusion Proteins; Time Factors | 1999 |
Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor.
Topics: Animals; Baclofen; GABA Agonists; Hot Temperature; Injections, Spinal; Injections, Subcutaneous; Isonicotinic Acids; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nociceptors; Physical Stimulation; Protein Isoforms; Receptors, GABA-A; Sensory Thresholds; Sex Characteristics | 2000 |
gamma-aminobutyric Acid(A) (GABA(A)) agonist 4,5,6, 7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol persistently increases sleep maintenance and intensity during chronic administration to rats.
Topics: Animals; Electroencephalography; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Sleep | 2000 |
Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Entropy; GABA Agonists; GABA Antagonists; Humans; Isoxazoles; L Cells; Membranes; Mice; Muscimol; Piperidines; Pyridazines; Receptors, GABA-A; Recombinant Proteins; Temperature; Tritium | 2001 |
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred CBA; Muscimol; Neuroprotective Agents; Picrotoxin | 2000 |
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Neurotransmitter Agents; Psychotic Disorders; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission | 2000 |
Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Cerebral Cortex; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Oocytes; Patch-Clamp Techniques; Piperidines; Pyridazines; Receptors, GABA-A; Xenopus laevis | 2001 |
Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects.
Topics: Aged; Double-Blind Method; Electroencephalography; Female; GABA Agonists; GABA-A Receptor Agonists; Hormones; Humans; Isoxazoles; Male; Middle Aged; Sleep; Sleep, REM; Wakefulness | 2001 |
Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.
Topics: Animals; Brain; Diffusion; Electrophysiology; Energy Metabolism; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Inhibitory Concentration 50; Isoxazoles; Kinetics; Muscimol; Phosphinic Acids; Protein Binding; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2001 |
Opposite roles of GABA and excitatory amino acids on the control of GAD expression in cultured retina cells.
Topics: Animals; Baclofen; Cells, Cultured; Chick Embryo; Cytarabine; Excitatory Amino Acid Agonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoxazoles; Kainic Acid; Nitric Oxide; Retina | 2002 |
Inhibition of THIP on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity.
Topics: Animals; Drug Tolerance; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Receptors, Dopamine | 2002 |
Characterization of GABA(A) receptor ligands in the rat cortical wedge preparation: evidence for action at extrasynaptic receptors?
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoxazoles; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synapses | 2002 |
GABAergic and glutamatergic terminals differentially influence the organization of GABAergic synapses in rat cerebellar granule cells in vitro.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cerebellar Cortex; Fluorescent Antibody Technique; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Presynaptic Terminals; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes; Synaptic Transmission; Vesicular Glutamate Transport Protein 1; Vesicular Transport Proteins | 2002 |
Gamma-aminobutyric acid-induced calcium signalling in rat superior collicular neurones.
Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Cytarabine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Neurons; Phosphinic Acids; Pyridines; Rats; Receptors, GABA; Superior Colliculi | 2002 |
Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Depressants; Chlorides; Ethanol; Etomidate; Female; Flurazepam; GABA Agonists; GABA Modulators; Gene Deletion; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Mice, Knockout; Pentobarbital; Postural Balance; Pyridines; Receptors, GABA; Receptors, GABA-A; Sex Characteristics; Sleep; Time Factors; Zolpidem | 2003 |
Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4betadelta GABA(A) receptors.
Topics: Animals; Anti-Anxiety Agents; Drug Implants; Female; GABA Agonists; Hippocampus; Ion Channels; Isoxazoles; Maze Learning; Pentobarbital; Premenstrual Syndrome; Progesterone; Protein Isoforms; Protein Subunits; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome | 2003 |
Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity.
Topics: Action Potentials; Animals; Benzodiazepines; Binding Sites; Cerebral Cortex; Drug Synergism; Ethanol; Female; GABA Agonists; Humans; In Vitro Techniques; Isoxazoles; Male; Neocortex; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus laevis | 2003 |
The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Hippocampus; Isoxazoles; Kainic Acid; Muscimol; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Propidium; Pyramidal Cells; Rats; Rats, Wistar; Time Factors | 2003 |
Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.
Topics: Animals; Chloride Channels; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Pyramidal Cells; Rats; Reaction Time; Receptors, GABA-A; Synaptic Transmission | 2003 |
Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors.
Topics: Animals; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Membrane Potentials; Neural Inhibition; Protein Subunits; Rats; Receptors, GABA-A | 2003 |
Aza-THIP and related analogues of THIP as GABA C antagonists.
Topics: Animals; Aza Compounds; GABA Antagonists; Humans; Isoxazoles; Kinetics; Magnetic Resonance Spectroscopy; Receptors, GABA; Recombinant Proteins; Xenopus | 2003 |
Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Ethanol; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test | 2003 |
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Body Temperature Regulation; Electroencephalography; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Isoxazoles; Lateral Ventricles; Male; Muscimol; Nipecotic Acids; Preoptic Area; Rabbits; Receptors, GABA-A; Receptors, GABA-B; Rectum; Somatosensory Cortex | 2004 |
Estradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat.
Topics: Anesthesia; Anesthetics; Animals; Drug Interactions; Estradiol; Female; GABA Agonists; Isoxazoles; Male; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Reflex; Sex Characteristics; Testosterone | 2004 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits.
Topics: Animals; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Deletion; Isoxazoles; Mice; Protein Subunits; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, GABA-A; Reflex; Tritium | 2004 |
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; GABA Agonists; Hippocampus; Isoxazoles; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Zolpidem | 2004 |
Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Isoxazoles; Male; Mice; Nitric Oxide Synthase; Nitroarginine; Pyrazoles; Pyridazines | 2004 |
Gaboxadol. Lundbeck/Merck.
Topics: Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dogs; Drug Evaluation, Preclinical; Drug Industry; GABA Agonists; Humans; Isoxazoles; Molecular Structure; Multicenter Studies as Topic; Patents as Topic; Randomized Controlled Trials as Topic; Rats; Sleep Initiation and Maintenance Disorders; Switzerland | 2004 |
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Topics: Analgesics, Non-Narcotic; Anxiety; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Hypnotics and Sedatives; Isoxazoles; Piperidines; Sleep Wake Disorders | 2004 |
Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.
Topics: Amino Acid Sequence; Amino Acids, Cyclic; Binding Sites; Carboxylic Acids; Cations; Crotonates; Cyclopropanes; Dose-Response Relationship, Drug; Electric Conductivity; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Imidazoles; Ion Channel Gating; Isoxazoles; Molecular Sequence Data; Molecular Structure; Muscimol; Mutagenesis, Site-Directed; Proline; Protein Subunits; Receptors, GABA; Static Electricity; Structure-Activity Relationship | 2004 |
Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density.
Topics: Animals; Antibodies; Blotting, Western; Brain; Carrier Proteins; Cells, Cultured; Clathrin-Coated Vesicles; Dynamins; Embryo, Mammalian; Extracellular Space; GABA-A Receptor Antagonists; Glucose Solution, Hypertonic; Immunohistochemistry; Isoxazoles; Membrane Proteins; Neurons; Peptides; Protein Subunits; Rats; Receptors, AMPA; Receptors, GABA-A; Synapses; Synapsins; Synaptic Transmission; Temperature; Time Factors | 2005 |
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women | 2005 |
The GABAA receptor agonist THIP alters the EEG in waking and sleep of mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Female; GABA Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Reaction Time; Sleep; Wakefulness | 2005 |
Effects of gabaergic drugs on reserpine-induced oral dyskinesia.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Baclofen; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; GABA Agents; Immobility Response, Tonic; Isoxazoles; Locomotion; Male; Rats; Rats, Wistar; Reserpine | 2005 |
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Ataxia; Behavior, Animal; Blotting, Western; Calcium; Central Nervous System Depressants; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Activation; Ethanol; Excitatory Amino Acid Antagonists; Food Preferences; GABA Agonists; Isoxazoles; Ketamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pentobarbital; Phosphorylation; Psychomotor Performance; Quinine; Reaction Time; Reflex; Saccharin; Sleep | 2005 |
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neuralgia; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Mechanical; Time Factors; Trauma, Nervous System; Zolpidem | 2005 |
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Blotting, Western; Cell Separation; Electrophysiology; Estradiol; Female; GABA Agonists; GABA Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Isoxazoles; Lanthanum; Lorazepam; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Steroids | 2005 |
Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons.
Topics: Anesthetics; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Central Nervous System Depressants; Cerebellum; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Ethanol; GABA Agonists; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Isoxazoles; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2005 |
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Azides; Benzodiazepines; Bicuculline; Blotting, Western; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Humans; Immunohistochemistry; Immunoprecipitation; In Vitro Techniques; Indoles; Isoxazoles; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Patch-Clamp Techniques; Prokaryotic Initiation Factors; Protein Subunits; Pyridines; Receptors, GABA-A; Synapses; Synaptophysin; Transfection; Ventral Thalamic Nuclei; Zinc Compounds; Zolpidem | 2005 |
THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex.
Topics: Analgesics; Animals; Animals, Newborn; Cells, Cultured; Electric Conductivity; Excitatory Postsynaptic Potentials; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neocortex; Neurons; Receptors, GABA-A; Synaptic Transmission | 2006 |
Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2.
Topics: Animals; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lanthanum; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis; Zinc | 2006 |
Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.
Topics: Animals; Anticonvulsants; Electrophysiology; Etomidate; GABA Modulators; Humans; Hypnotics and Sedatives; Isoxazoles; Oocytes; Patch-Clamp Techniques; Propofol; Receptors, GABA-A; Xenopus | 2006 |
Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Morphine; Muscimol; Narcotics; Neurons; Nociceptors; Pain Measurement; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time | 2006 |
The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity.
Topics: Action Potentials; Analysis of Variance; Anesthetics; Animals; Drug Interactions; Female; GABA Agonists; In Vitro Techniques; Isoxazoles; Muscimol; Neural Inhibition; Neurons; Pregnanolone; Progesterone; Raphe Nuclei; Rats; Receptors, GABA-A; Serotonin; Time Factors | 2007 |
delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol.
Topics: Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Female; GABA Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscimol; Receptors, GABA-A | 2006 |
KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Diazepam; Ethanol; Exploratory Behavior; Hippocampus; Immobility Response, Tonic; In Vitro Techniques; Isoxazoles; K Cl- Cotransporters; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Skills Disorders; Neurons; Symporters | 2007 |
GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.
Topics: Animals; Dentate Gyrus; GABA-A Receptor Agonists; Isoxazoles; Mice; Mice, Knockout; Receptors, GABA-A; Thalamus | 2006 |
A single point mutation of the GABA(A) receptor alpha5-subunit confers fluoxetine sensitivity.
Topics: Amino Acid Substitution; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fluoxetine; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Xenopus laevis | 2007 |
Auto-modulation of neuroactive steroids on GABA A receptors: a novel pharmacological effect.
Topics: Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Membrane Potentials; Patch-Clamp Techniques; Pregnanediones; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Steroids | 2007 |
Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; GABA Agonists; Generalization, Psychological; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Sleep | 2007 |
Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex.
Topics: Animals; Dose-Response Relationship, Radiation; Drug Interactions; GABA Agonists; GABA Modulators; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Membrane Potentials; Mice; Neocortex; Neurons; Patch-Clamp Techniques; Reaction Time; Receptors, GABA-A | 2007 |
Lack of generalisation between the GABAA receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Discrimination Learning; Drug Interactions; GABA-A Receptor Agonists; Generalization, Psychological; Isoxazoles; Male; Rats; Rats, Wistar | 2007 |
Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration.
Topics: Animals; Central Nervous System; Chromatography, Liquid; GABA Agonists; Infusion Pumps; Injections, Subcutaneous; Isoxazoles; Male; Mass Spectrometry; Microdialysis; Rats; Rats, Wistar; Time Factors | 2007 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Isoxazoles; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Pharmacogenetics; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Reproducibility of Results; Species Specificity | 2007 |
The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; GABA Agonists; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Reaction Time; Receptors, GABA-A; Sleep; Wakefulness | 2007 |
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
Topics: Animals; Bicuculline; Electrophysiology; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Medulla Oblongata; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Synapses | 2007 |
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Subcellular Fractions | 2007 |
GABAergic modulation of binge-like ethanol intake in C57BL/6J mice.
Topics: Alcoholism; Animals; Baclofen; Central Nervous System Depressants; Darkness; Dose-Response Relationship, Drug; Ethanol; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Postural Balance | 2007 |
Development and validation of a selective and sensitive bioanalytical procedure for the quantitative determination of gaboxadol in human plasma employing mixed mode solid phase extraction and hydrophilic interaction liquid chromatography with tandem mass
Topics: Chromatography, Liquid; Humans; Isoxazoles; Molecular Structure; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2007 |
Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors.
Topics: Animals; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dark Adaptation; Dose-Response Relationship, Drug; Exploratory Behavior; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Isoxazoles; Male; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Binding; Protein Subunits; Reaction Time; Receptors, GABA-A; Reflex; Thy-1 Antigens; Transfection | 2008 |
The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.
Topics: Animals; Dentate Gyrus; Diazepam; Female; GABA Agonists; GABA Modulators; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Protein Isoforms; Receptors, GABA; Receptors, GABA-A; Synapses | 2008 |
Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors.
Topics: Animals; Cell Line; Computer Simulation; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Isoxazoles; Kinetics; Membrane Potentials; Mice; Models, Chemical; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; Transfection | 2008 |
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem | 2008 |
Sleep-stabilizing effects of E-6199, compared to zopiclone, zolpidem and THIP in mice.
Topics: Animals; Azabicyclo Compounds; Electroencephalography; Hypnotics and Sedatives; Isoxazoles; Mice; Piperazines; Polysomnography; Pyridines; Sleep; Sleep Stages; Sleep Wake Disorders; Zolpidem | 2008 |
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Electrodes, Implanted; Electroencephalography; GABA Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep | 2008 |
Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep-wakefulness: role of delta-subunit containing extrasynaptic GABAA receptors.
Topics: Animals; GABA Agonists; Hypothalamus; Injections, Intraventricular; Isoxazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Wakefulness | 2008 |
Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex.
Topics: Anesthetics; Animals; Animals, Newborn; Desoxycorticosterone; Drug Interactions; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Neocortex; Neural Inhibition; Neurons; Patch-Clamp Techniques; Reaction Time; Receptors, GABA-A | 2008 |
Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
Topics: Action Potentials; Animals; Cerebral Cortex; Dose-Response Relationship, Radiation; Electric Stimulation; Female; GABA Agonists; In Vitro Techniques; Isoxazoles; Lysine; Male; Mice; Mice, Inbred C57BL; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Thalamus | 2008 |
Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Drug Interactions; Ethanol; GABA Agonists; Hypothalamus; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Up-Regulation | 2008 |
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.
Topics: Animals; Cerebral Cortex; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Homeostasis; Isoxazoles; Long-Term Potentiation; Models, Neurological; Neural Inhibition; Neuronal Plasticity; Organ Culture Techniques; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2008 |
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.
Topics: Animals; Binding Sites; Brain; Cell Line; Electrophysiology; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
Topics: Allosteric Regulation; Animals; Benzimidazoles; Benzodiazepinones; Diazepam; GABA Modulators; Humans; Inflammation; Isoxazoles; Neuralgia; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 2008 |
Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.
Topics: Administration, Oral; Animals; Biotransformation; CHO Cells; Chromatography, Liquid; Cricetinae; Cricetulus; GABA Agonists; Glucuronides; Glucuronosyltransferase; Humans; Isoenzymes; Isoxazoles; Kidney; Liver; Membrane Transport Proteins; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Recombinant Proteins; Tandem Mass Spectrometry; Transfection; UDP-Glucuronosyltransferase 1A9 | 2009 |
Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique.
Topics: Animals; Brain; Central Nervous System Agents; Citalopram; Extracellular Space; Isoxazoles; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Wistar | 2009 |
Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress.
Topics: Acute Disease; Anesthetics; Animals; Anti-Anxiety Agents; Body Temperature; Carbolines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA Agents; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Motor Activity; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Psychological; Telemetry; Zolpidem | 2009 |
Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor.
Topics: Animals; Circadian Rhythm; Cricetinae; GABA Agonists; GABA-A Receptor Agonists; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Mesocricetus; Muscimol; Period Circadian Proteins; Photoperiod; Receptors, GABA-A; RNA, Messenger; Suprachiasmatic Nucleus | 2009 |
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Agonists; GABA Antagonists; Glycine Agents; In Vitro Techniques; Isoxazoles; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neural Inhibition; Patch-Clamp Techniques; Receptors, GABA-A; Strychnine; Thalamus; Time Factors | 2009 |
The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning.
Topics: Anesthetics; Animals; Behavior, Animal; Brain; Conditioning, Classical; Electroshock; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Learning; Motor Activity; Neural Inhibition; Photic Stimulation; Rabbits; Receptors, GABA-B | 2009 |
Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Flumazenil; GABA Modulators; Isoxazoles; Lorazepam; Male; Maze Learning; Midazolam; Motor Activity; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2009 |
The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors.
Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Neural Inhibition; Neurons; Neurotransmitter Agents; Raphe Nuclei; Rats; Receptors, GABA-A; Serotonin | 2010 |
Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem.
Topics: Adult; Affect; Arousal; Attention; Automobile Driving; Azabicyclo Compounds; Cognition; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Humans; Isoxazoles; Male; Memory, Short-Term; Neuropsychological Tests; Orientation; Piperazines; Postural Balance; Psychomotor Performance; Pyridines; Reaction Time; Retention, Psychology; Sleep Initiation and Maintenance Disorders; Young Adult; Zolpidem | 2009 |
Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan.
Topics: Administration, Oral; Amino Acid Transport Systems; Animals; Area Under Curve; Biological Availability; Caco-2 Cells; Dogs; Drug Interactions; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Intestinal Absorption; Isoxazoles; Male; Symporters; Tissue Distribution; Tryptophan | 2009 |
Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.
Topics: Animals; Anti-Anxiety Agents; Biophysical Phenomena; Central Nervous System Depressants; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethanol; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Transfection; Xenopus | 2009 |
5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.
Topics: 5-Hydroxytryptophan; Amino Acid Transport Systems; Animals; Biological Transport; Caco-2 Cells; Drug Interactions; Gastric Emptying; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Male; Oocytes; Organic Anion Transport Protein 1; Rats; Rats, Sprague-Dawley; Symporters; Xenopus laevis | 2010 |
Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus.
Topics: Action Potentials; Anesthetics; Animals; Animals, Newborn; Biophysics; Electric Stimulation; GABA Agonists; Glycine; Hypoglossal Nerve; Isoxazoles; Medulla Oblongata; Motor Neurons; Patch-Clamp Techniques; Pregnanolone; Progesterone; Progestins; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2009 |
Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.
Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Animals; Benzodiazepines; Brain; Crosses, Genetic; Ethanol; Flurazepam; GABA Agonists; Genotype; Glutamate Decarboxylase; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Neurologic Mutants; Motor Skills; Phenotype; Postural Balance; Species Specificity; Taste | 2010 |
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Male; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2011 |
Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Fibroblasts; GABA Agonists; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Isoxazoles; Kidney; Mice; Muscimol; Patch-Clamp Techniques; Receptors, GABA-A; Synapses; Transfection | 2010 |
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Temperature; Time Factors | 2010 |
Pulvinar inactivation disrupts selection of movement plans.
Topics: Animals; Behavior, Animal; Brain Mapping; Decision Making; Electrophysiology; Eye Movements; Female; GABA Agonists; Isoxazoles; Macaca mulatta; Magnetic Resonance Imaging; Male; Motor Activity; Muscimol; Neurons; Pulvinar; Visual Fields | 2010 |
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Interneurons; Isoxazoles; Male; Mice; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Synaptic Transmission | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Exploratory Behavior; Female; GABA-A Receptor Agonists; Isoxazoles; Motor Activity; Phencyclidine; Rats; Receptors, GABA-A; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Time Factors | 2011 |
Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol.
Topics: Amino Acid Transport Systems; Caco-2 Cells; GABA Agonists; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Isoxazoles; Models, Molecular; Symporters | 2011 |
Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.
Topics: Animals; Association Learning; Electrophysiological Phenomena; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Interneurons; Isoxazoles; Male; Mice; Neural Conduction; Neurons; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Sex Characteristics; Somatosensory Cortex | 2011 |
Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus.
Topics: Animals; Auditory Pathways; Isoxazoles; Neural Inhibition; Protein Subunits; Rats; Receptors, GABA-A; Thalamus | 2011 |
Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.
Topics: Action Potentials; Analgesics; Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Formaldehyde; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hindlimb Suspension; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Pain Measurement; Psychomotor Performance; Receptors, GABA-A; Sensory Receptor Cells; Spinal Cord | 2011 |
Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; GABA Modulators; Isoxazoles; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mimosa; N-Methylaspartate; Phytotherapy; Plant Extracts; Raphe Nuclei; Receptors, GABA-A; Serotonin | 2012 |
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.
Topics: Animals; Anticonvulsants; Ataxia; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Plasma Membrane Transport Proteins; Isoxazoles; Male; Mice; Nipecotic Acids; Receptors, GABA-A; Synapses; Tiagabine | 2011 |
Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.
Topics: Animals; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Patch-Clamp Techniques; Purkinje Cells; Receptor Aggregation; Receptors, GABA-A; Synaptic Potentials | 2011 |
Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Finasteride; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Models, Animal; Pregnanolone; Receptors, GABA-A | 2011 |
Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.
Topics: Animals; Cerebellar Cortex; Dose-Response Relationship, Drug; GABA Agonists; GABAergic Neurons; HEK293 Cells; Humans; Isoxazoles; Mice; Mice, Knockout; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Protein Multimerization; Protein Subunits; Receptors, GABA-A; Recombinant Fusion Proteins; Solubility; Xenopus laevis | 2011 |
Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.
Topics: Animals; Asthma; Benzodiazepines; Cell Line; Chlorides; GABA-A Receptor Agonists; Guinea Pigs; Humans; Isoxazoles; Laser Capture Microdissection; Ligands; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Receptors, GABA-A; RNA, Messenger; Taurine; Trachea | 2012 |
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Neuropsychological Tests; Receptors, GABA-A | 2011 |
Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Sodium Channel Blockers; Solitary Nucleus; Tetrodotoxin | 2012 |
Effects of general anaesthetics on 5-HT neuronal activity in the dorsal raphe nucleus.
Topics: Action Potentials; Anesthetics, General; Animals; Chloral Hydrate; Hypnotics and Sedatives; Isoxazoles; Ketamine; Male; N-Methylaspartate; Pentobarbital; Raphe Nuclei; Rats; Serotonergic Neurons; Serotonin; Urethane | 2012 |
Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons.
Topics: Animals; Bicuculline; Blotting, Western; Cells, Cultured; Crotonates; Electrophysiological Phenomena; GABA Agonists; GABA Antagonists; Ganglia, Spinal; Isoxazoles; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Time Factors; Up-Regulation | 2012 |
Synergistic antidepressant-like action of gaboxadol and escitalopram.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; Drug Resistance; Drug Synergism; Drug Therapy, Combination; GABA-A Receptor Agonists; Isoxazoles; Male; Neurogenesis; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Up-Regulation | 2012 |
Intracellular chloride concentration influences the GABAA receptor subunit composition.
Topics: Animals; Bumetanide; Carboxylic Acids; Cells, Cultured; Cerebellum; Chlorides; gamma-Aminobutyric Acid; Indenes; Isoxazoles; K Cl- Cotransporters; Mice; Neurons; Patch-Clamp Techniques; Protein Subunits; Pyridines; Receptors, GABA-A; RNA Interference; RNA, Small Interfering; Symporters; Zolpidem | 2012 |
GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons.
Topics: Animals; Behavior, Animal; Dopaminergic Neurons; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; GABA Agonists; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuronal Plasticity; Papio; Polymerase Chain Reaction; Receptors, AMPA; Receptors, GABA-A; Reward; Self Administration; Substance-Related Disorders; Ventral Tegmental Area | 2012 |
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Topics: Analgesia; Analgesics; Animals; Benzodiazepines; Chlorides; GABA-A Receptor Agonists; Isoxazoles; K Cl- Cotransporters; Male; Mice; Mice, Inbred ICR; Muscimol; Neuralgia; Peripheral Nerve Injuries; Pregnanolone; Receptors, GABA-A; Sciatic Nerve; Symporters | 2012 |
Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.
Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Isoxazoles; Larva; Membrane Potentials; Models, Biological; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus | 2012 |
Function and expression of the proton-coupled amino acid transporter PAT1 along the rat gastrointestinal tract: implications for intestinal absorption of gaboxadol.
Topics: Administration, Oral; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Biological Availability; Biological Transport; Caco-2 Cells; Gastrointestinal Tract; Humans; Intestinal Absorption; Isoxazoles; Male; Proline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Symporters; Tryptophan; Xenopus laevis | 2012 |
Positive modulation of δ-subunit containing GABA(A) receptors in mouse neurons.
Topics: Animals; Anxiety; Brain; Calcium; Data Interpretation, Statistical; Dentate Gyrus; Electrophysiological Phenomena; Fever; GABA Agents; GABA Agonists; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Radioligand Assay; Receptors, GABA-A; Stress, Psychological; Synaptic Transmission | 2012 |
The role of GABAergic system on the inhibitory effect of ghrelin on food intake in neonatal chicks.
Topics: Animals; Animals, Newborn; Brain; Chickens; Eating; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Ghrelin; Glutamate Decarboxylase; Injections, Intraventricular; Isoxazoles; Picrotoxin; Receptors, GABA-A; RNA, Messenger | 2012 |
Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drugs, Investigational; Ethanol; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Nootropic Agents; Pregnanolone; Protein Subunits; Receptors, GABA-A; Reinforcement, Psychology; Self Administration; Time Factors | 2012 |
Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides.
Topics: Administration, Oral; Amino Acid Transport Systems; Animals; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Dipeptides; Glycine; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Isoxazoles; Male; Oocytes; Protons; Rats; Rats, Sprague-Dawley; Symporters; Xenopus laevis | 2012 |
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Cerebellar Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Functional Laterality; GABA Agonists; GABA Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Ketamine; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Physical Stimulation; Pyridazines; Rats; Rats, Sprague-Dawley; Sensation; Vibrissae | 2012 |
Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Central Nervous System Depressants; Diazepam; Electrophysiological Phenomena; Ethanol; GABA Modulators; Isoxazoles; Male; Membranes; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Thyroid Hormones; Thyroxine | 2013 |
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Mice; Purkinje Cells; Ubiquitin-Protein Ligases | 2012 |
Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.
Topics: Animals; Electroencephalography; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Microinjections; Muscimol; Pons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reticular Formation; Sleep; Sodium Chloride; Wakefulness | 2013 |
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission | 2013 |
γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus.
Topics: Analysis of Variance; Animals; Dentate Gyrus; Discrimination, Psychological; Electroshock; Exploratory Behavior; GABA Agonists; Isoxazoles; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Receptors, GABA-A; Recognition, Psychology | 2013 |
Discriminative stimulus effects of pregnanolone in rhesus monkeys.
Topics: Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA Modulators; Gonadal Steroid Hormones; Hypnotics and Sedatives; Isoxazoles; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule | 2014 |
Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.
Topics: Administration, Oral; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Area Under Curve; Biological Availability; Caco-2 Cells; Chromatography; Dose-Response Relationship, Drug; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Male; Peptide Transporter 1; Proline; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sertraline; Sodium-Glucose Transporter 1; Symporters; Tandem Mass Spectrometry; Xenopus laevis | 2013 |
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.
Topics: Action Potentials; Animals; Cerebellum; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glutamates; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Mice, Inbred C57BL; Neural Inhibition; Neurons; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Synapses; Synaptic Transmission | 2013 |
Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus.
Topics: Animals; Conditioning, Psychological; Cues; Fear; GABA Agonists; Hippocampus; Isoxazoles; Long-Term Potentiation; Maze Learning; Memory; Mice; Mice, Knockout; Receptors, GABA-A; Recognition, Psychology | 2013 |
Modulation of stimulus-specific adaptation by GABA(A) receptor activation or blockade in the medial geniculate body of the anaesthetized rat.
Topics: Acoustic Stimulation; Adaptation, Physiological; Anesthesia, General; Animals; GABA Antagonists; GABA-A Receptor Agonists; GABAergic Neurons; Geniculate Bodies; Isoxazoles; Male; Pyridazines; Rats; Rats, Inbred F344; Receptors, GABA-A | 2014 |
Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?
Topics: Animals; Chlorides; GABA-A Receptor Agonists; GABAergic Neurons; gamma-Aminobutyric Acid; Geniculate Bodies; Inferior Colliculi; Isoxazoles; Male; Rats; Rats, Inbred F344; Rats, Long-Evans; Receptors, GABA-A; Synapses; Synaptic Potentials | 2014 |
Enantiotropically related polymorphs of gaboxadol hydrochloride.
Topics: Crystallization; Isoxazoles; Models, Molecular; Temperature; X-Ray Diffraction | 2013 |
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation | 2014 |
Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats.
Topics: Animals; Central Nervous System Depressants; Cerebellum; Developmental Disabilities; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Isoxazoles; Membrane Potentials; Motor Activity; Neurons; Pregnancy; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2014 |
Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics.
Topics: Animals; Corpus Striatum; Female; GABA Agonists; Isoxazoles; Male; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; Synapses | 2013 |
Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3.
Topics: Animals; Anisoles; Astrocytes; Corpus Striatum; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Huntington Disease; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Transgenic; Neural Inhibition; Neurons; Nipecotic Acids; Patch-Clamp Techniques; Synaptic Transmission | 2013 |
Excitatory/inhibitory equilibrium of the central amygdala nucleus gates anti-depressive and anxiolytic states in the hamster.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Anxiety; Behavior, Animal; Cricetinae; Depression; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mesocricetus; Microinjections; Receptors, AMPA; RNA, Messenger; Stress, Physiological | 2014 |
GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo.
Topics: Action Potentials; Animals; Biophysics; Calcium; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Functional Laterality; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Oxygen Consumption; Partial Pressure; Pyridines; Receptors, GABA-A; Somatosensory Cortex; Sulfonamides; Thiazoles; Vibrissae; Zolpidem | 2015 |
Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala.
Topics: Amygdala; Animals; Desoxycorticosterone; Diazepam; GABA Modulators; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Mice; Neural Inhibition; Receptors, GABA-A | 2014 |
Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABAA receptors.
Topics: Amino Acid Sequence; Cell Polarity; DNA, Complementary; GABA Agonists; HEK293 Cells; Humans; Isoxazoles; Molecular Sequence Data; Mutant Chimeric Proteins; Neurotransmitter Agents; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Transfection | 2014 |
Contributions of the hippocampus and entorhinal cortex to rapid visuomotor learning in rhesus monkeys.
Topics: Animals; Association Learning; Entorhinal Cortex; GABA-A Receptor Agonists; Hippocampus; Isoxazoles; Macaca mulatta; Magnetic Resonance Imaging; Male; Memory; Neuropsychological Tests; Psychomotor Performance; Thinking; Time Factors; Visual Perception | 2014 |
Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol.
Topics: Animals; Behavior, Animal; Ethanol; Extinction, Psychological; GABA Agonists; Isoxazoles; Male; Mice, Inbred C57BL; Pregnanolone; Receptors, GABA-A | 2014 |
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala.
Topics: Amygdala; Animals; Excitatory Postsynaptic Potentials; Feedback, Physiological; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Phthalazines; Protein Subunits; Pyridazines; Receptors, GABA-A; Synapses; Triazoles | 2014 |
Extrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning.
Topics: Animals; Extinction, Psychological; Fear; Integrases; Isoxazoles; Male; Mediodorsal Thalamic Nucleus; Mice; Mice, Knockout; Pyridazines; Receptors, GABA-A; Synapses; Transfection | 2014 |
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neurons; Seizures; Synapsins | 2015 |
Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice.
Topics: Alcohol Drinking; Animals; Ethanol; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microinjections; Motor Activity; Prefrontal Cortex; Receptors, GABA-A | 2014 |
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Membrane Potentials; Neurons; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2014 |
Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.
Topics: Alcohol Drinking; Animals; Ethanol; GABA-A Receptor Agonists; Infusions, Intraventricular; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Pregnanolone; Receptors, GABA-A; Treatment Outcome | 2015 |
Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.
Topics: Anesthetics, General; Cell Line, Tumor; Diazepam; Drug Synergism; Electrophysiological Phenomena; Etomidate; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Ion Channel Gating; Isoxazoles; Propofol; Protein Subunits; Protein Transport; Receptors, GABA-A | 2015 |
Paradoxical widespread c-Fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) α6 subunit.
Topics: Animals; Anti-Anxiety Agents; Female; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Prosencephalon; Protein Subunits; Proto-Oncogene Proteins c-fos; Radionuclide Imaging; Receptors, GABA-A | 2015 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Muscarinic Agonists; Neurons; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Valine | 2015 |
Sleep restores behavioral plasticity to Drosophila mutants.
Topics: Adenylyl Cyclases; Alzheimer Disease; Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Fatty Acid-Binding Proteins; Female; Isoxazoles; Male; Memory, Long-Term; Memory, Short-Term; Mutation; Organophosphorus Compounds; Receptors, GABA; Reserpine; Sleep | 2015 |
Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING.
Topics: Animals; Bicuculline; GABA Agonists; GABAergic Neurons; Humans; Isoxazoles; Locus Coeruleus; Methyl-CpG-Binding Protein 2; Mice; Mice, Transgenic; Receptors, GABA; Receptors, GABA-A; Respiration; Rett Syndrome; Single-Cell Analysis; Synapses | 2015 |
Diabetes induces GABA receptor plasticity in murine vagal motor neurons.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Immunohistochemistry; Isoxazoles; Male; Membrane Potentials; Mice; Motor Neurons; Muscimol; Neuronal Plasticity; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Synapses; Vagus Nerve | 2015 |
Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.
Topics: Animals; Arousal; Behavior, Animal; Dopamine; Drosophila melanogaster; GABA Agonists; Isoxazoles; Learning; Memory; Models, Animal; Neuronal Plasticity; Neurons; Sleep | 2015 |
GABAergic mechanisms regulated by miR-33 encode state-dependent fear.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; GABA Agonists; GABAergic Neurons; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Organ Culture Techniques; Receptors, GABA-A | 2015 |
Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption.
Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dogs; Drug Liberation; Humans; Intestinal Absorption; Isoxazoles; Male; Pharmacokinetics; Solubility; Swine; Swine, Miniature | 2016 |
Regulation of Extrasynaptic GABAA α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Activators; Ethanol; Female; GABA Antagonists; Isoxazoles; Male; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses | 2016 |
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.
Topics: Botulinum Toxins, Type A; Cell Membrane; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Dynamins; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrazones; Immunohistochemistry; Isoxazoles; Leupeptins; Membrane Potentials; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Transfection | 2016 |
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
Topics: Aminolevulinic Acid; Animals; beta-Alanine; Caco-2 Cells; Cell Line; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kidney; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Osmolar Concentration; Osmosis; Proline; Rats; RNA, Messenger; Swine; Taurine; Vigabatrin | 2016 |
Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
Topics: Action Potentials; Animals; Dentate Gyrus; GABA Agonists; GABA Antagonists; Gene Expression Regulation; Genetic Vectors; Humans; Isoxazoles; Male; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Neurons; Pentylenetetrazole; Protein Subunits; Pyrimidines; Receptors, GABA-A; Somatostatin | 2015 |
Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Electric Stimulation; Functional Laterality; GABA Agonists; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Neurons; Receptors, GABA-A; RNA, Messenger; Signal Transduction | 2016 |
Involvement of the GABAA Receptor in Age-Dependent Differences in Binge-Like Ethanol Intake.
Topics: Age Factors; Animals; Binge Drinking; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Receptors, GABA-A | 2016 |
Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Agonists; GABA Modulators; Isoxazoles; Male; Midazolam; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A | 2016 |
Effects of gaboxadol on the expression of cocaine sensitization in rats.
Topics: Animals; Central Nervous System Sensitization; Cocaine; Dose-Response Relationship, Drug; Female; GABA Agonists; Injections, Subcutaneous; Isoxazoles; Locomotion; Male; Microinjections; Nucleus Accumbens; Rats; Receptors, GABA-A; Stereotyped Behavior | 2016 |
Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Functional Laterality; GABA Agents; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Immunosuppressive Agents; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors | 2016 |
A pharmacological characterization of GABA, THIP and DS2 at binary α4β3 and β3δ receptors: GABA activates β3δ receptors via the β3(+)δ(-) interface.
Topics: Animals; Benzamides; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus laevis | 2016 |
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.
Topics: Age Factors; Animals; Benzamides; CA1 Region, Hippocampal; Cations, Monovalent; Evoked Potentials; Female; GABA-A Receptor Agonists; Imidazoles; In Vitro Techniques; Isoxazoles; Mice, Inbred C57BL; Models, Neurological; Potassium; Receptors, GABA-A; Seizures; Sexual Maturation | 2016 |
Pharmacologically Counteracting a Phenotypic Difference in Cerebellar GABAA Receptor Response to Alcohol Prevents Excessive Alcohol Consumption in a High Alcohol-Consuming Rodent Genotype.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; Genotype; In Vitro Techniques; Isoxazoles; Kynurenic Acid; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Patch-Clamp Techniques; Pyridazines; Receptors, GABA-A; Species Specificity; Sucrose | 2016 |
Effects of chronic exposure to low dose THIP on brainstem neuronal excitability in mouse models of Rett syndrome: Evidence from symptomatic females.
Topics: Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Isoxazoles; Membrane Potentials; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Random Allocation; Rett Syndrome; Tissue Culture Techniques | 2017 |
Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice.
Topics: Animals; Brain; Cognition; Disease Models, Animal; Dystrophin; Fear; GABAergic Neurons; Humans; Isoxazoles; Mice; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Receptors, GABA-A; Stress, Psychological | 2017 |
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Knockout Techniques; Hyperalgesia; Inflammation; Isoxazoles; Male; Muscimol; Optogenetics; Patch-Clamp Techniques; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission; Thalamus | 2017 |
α4βδ GABA
Topics: Aging; Animals; CA1 Region, Hippocampal; Dendritic Spines; Female; GABA-A Receptor Agonists; Isoxazoles; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Pregnanolone; Receptors, GABA-A; Spatial Learning | 2017 |
Perinatal high fat diet increases inhibition of dorsal motor nucleus of the vagus neurons regulating gastric functions.
Topics: Animals; Bicuculline; Brain Stem; Diet, High-Fat; GABA Agonists; GABA Antagonists; Gastrointestinal Motility; Isoxazoles; Male; Neural Inhibition; Neurons; Pyridazines; Rats, Sprague-Dawley; Vagus Nerve | 2018 |
Interaction between central GABAA receptor and dopaminergic system on food intake in neonatal chicks: role of D
Topics: Adrenergic Agents; Analysis of Variance; Animals; Animals, Newborn; Benzazepines; Chickens; Dopamine; Dopamine Agents; Eating; Female; Food Deprivation; GABA Agents; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Levodopa; Oxidopamine; Receptors, Dopamine D1; Receptors, GABA-A | 2018 |
Oscillatory brain activity in spontaneous and induced sleep stages in flies.
Topics: Animals; Brain; Diptera; Drosophila melanogaster; Electrophysiology; Female; Isoxazoles; Nervous System Physiological Phenomena; Neurons; Sleep; Sleep Stages; Time Factors | 2017 |
Enhanced Activities of δ Subunit-containing GABA
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; GABA-A Receptor Agonists; Isoxazoles; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; Pain; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord; Synapses | 2018 |
Modulation of the zebrafish optokinetic reflex by pharmacologic agents targeting GABA
Topics: Animals; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoxazoles; Nystagmus, Optokinetic; Photic Stimulation; Picrotoxin; Reflex; Saccades; Zebrafish | 2018 |
Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Grooming; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Receptor, trkB | 2019 |
Excitatory/inhibitory balance across ontogeny contributes to age-specific behavioral outcomes of ethanol-like challenge in conditioned taste aversion.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditioning, Classical; Ethanol; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Agonists; Isoxazoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Taste Perception | 2019 |
How well can a large number of polysomnography sleep measures predict subjective sleep quality in insomnia patients?
Topics: Age Factors; Analgesics; Azepines; Female; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Predictive Value of Tests; Sleep Aids, Pharmaceutical; Sleep Hygiene; Sleep Initiation and Maintenance Disorders; Time Factors; Triazoles | 2020 |
Upcoming market catalysts in Q3 2020.
Topics: Angelman Syndrome; Azo Compounds; Drug Approval; Fatty Acids; Humans; Isoxazoles; Muscular Atrophy, Spinal; Pyrimidines; Triglycerides; United States | 2020 |
Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit.
Topics: Animals; Astacoidea; Ethanol; GABA Agonists; GABA-A Receptor Antagonists; GABAergic Neurons; Interneurons; Isoxazoles; Phosphinic Acids; Pyridines; Social Behavior; Synaptic Potentials | 2021 |
High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABA
Topics: Amnesia; Animals; Behavior, Animal; Central Nervous System Depressants; Choice Behavior; Conditioning, Classical; Ethanol; Fear; GABA Agonists; Hippocampus; Isoxazoles; Mammillary Bodies; Memory; Memory, Episodic; Mice; MicroRNAs; Neural Inhibition; Neural Pathways; Neurons; Pyramidal Cells; Receptors, GABA-A; RNA, Messenger | 2021 |