Page last updated: 2024-08-21

isoxazoles and gaboxadol

isoxazoles has been researched along with gaboxadol in 473 studies

Research

Studies (473)

TimeframeStudies, this research(%)All Research%
pre-1990183 (38.69)18.7374
1990's76 (16.07)18.2507
2000's101 (21.35)29.6817
2010's107 (22.62)24.3611
2020's6 (1.27)2.80

Authors

AuthorsStudies
Polc, P1
Karobath, M; Lippitsch, M1
Curtis, DR; Johnston, GA; Lodge, D1
Aprison, MH; Lipkowitz, KB1
Graeff, FG; Silveira, MC1
Johnston, GA2
Belhage, B; Hansen, GH; Schousboe, A2
Garant, DS; Moshé, SL; Sperber, EF; Xu, SG2
Bonaventure, N; Jardon, B; Kim, MS; Yücel, H1
Amit, Z; Robidoux, J; Smith, BR1
Amit, Z; Boyle, AE; Smith, BR1
Ebbesson, SO; Erdö, SL; Hofmann, MH; Malz, CR; Meyer, DL1
Snead, OC1
Bapna, JS; Ramaswamy, S; Srinivasan, D1
Bonaventure, N; Jardon, B1
Ramsey, VA; Rosenberg, HC; Tietz, EI1
Barolet, AW; Morris, ME1
Diemer, NH; Johansen, FF1
Agmo, A; Gutiérrez, M; Guzmán, M; Pruneda, R1
Bergen, HT; Hejtmancik, JF; Pfaff, DW1
Fromm, GH; Mukawa, J; Nakata, M1
Heinricher, MM; Kaplan, HJ1
Bapna, JS; Rajaram, S; Ramaswamy, S1
Corbett, R; Cornfeldt, M; Dunn, RW; Fielding, S1
Boelen, MK; Chubb, IW; Dowton, M; Morgan, IG; Wellard, J1
Hablitz, JJ; Mistry, DK1
Bapna, JS; Ramaswamy, S; Srinivasan, B; Srinivasan, D1
Jodogne, C; Tirelli, E1
Catt, KJ; Stojilković, SS; Virmani, MA1
Belhage, B; Hansen, GH; Meier, E; Schousboe, A4
Balcar, VJ; Dreher, B1
Michler, A1
Hicks, TP; Kaneko, T1
Bonaventure, N; Jardon, B; Kim, MS; Yucel, YH1
Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA1
Amenta, F; Erdö, SL; Mione, MC; Wolff, JR1
Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M1
Agmo, A; Paredes, R; Soria, P1
Erdö, SL; Michler, A1
Liske, S; Morris, ME3
Karlsson, G; Olpe, HR1
Bapna, JS; Ramaswamy, S; Suthakaran, C1
Andersen, JV; Dalgaard, L; Hansen, SH1
Aarslew-Jensen, M; Diemer, NH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A1
Graeff, FG; Milani, H1
Fujimoto, M; Guidotti, A; Hanbauer, I; Kataoka, Y1
Thalmann, RH2
Pooler, GW; Steward, EG1
Andre, JM; Boulanger, T; Durant, F; Vercauteren, DP1
Cosi, C; Wood, PL1
Spealman, RD; Wettstein, JG1
Mehta, AK; Ticku, MK1
Bitran, D; Leipheimer, RE; McQuade, DB; Miller, SA; Sachs, BD1
Beani, L; Bianchi, C; Tanganelli, S1
Bond, A; Neal, H2
Hansen, SH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A1
Meldrum, BS1
Ator, NA; Griffiths, RR1
Bruno, G; Chase, TN; Cox, C; Fedio, P; Foster, N; Gillespie, M; Hare, TA; Mohr, E; Tamminga, C1
Alho, H; Fujimoto, M; Geffard, M; Guidotti, A; Hanbauer, I; Kataoka, Y; Kelly, GD1
Borsini, F; Giuliani, S; Meli, A2
Andersson, U; Häggström, JE1
Bagri, A; Di Scala, G; Sandner, G1
Karobath, M; Supavilai, P3
Iversen, LL; Wong, EH1
Chrousos, GP; Crawley, JN; Linnoila, M; Ninan, PT; Paul, SM; Pickar, D; Skolnick, P1
Chweh, AY; Kupferberg, HJ; Swinyard, EA; Wolf, HH1
Costa, LG; Enna, SJ; Pelley, K; Setler, P; Vaught, JL1
Gianutsos, G; Suzdak, PD2
Agmo, A; Paredes, R1
Löscher, W; Schwark, WS1
Gähwiler, BH; Graff, P; Maurer, R; Nordmann, R1
Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM2
Agmo, A; Giordano, M1
Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Nielsen, L1
Depaulis, A; Liebeskind, JC; Morgan, MM2
Depaulis, A; Vergnes, M4
Brandao, ML; Di Scala, G; Karli, P; Schmitt, P1
Hösli, E; Hösli, L; Krogsgaard-Larsen, P1
Bristow, DR; Watling, KJ1
Chweh, AY; Swinyard, EA; Ulloque, RA1
Chweh, AY; Lin-Michell, E; Swinyard, EA1
Allan, AM; Harris, RA1
Ciesielski, L; Gobaille, S; Mandel, P; Molina, V1
Belhage, B; Meier, E; Schousboe, A1
Falch, E; Hjeds, H; Krogsgaard-Larsen, P1
Braestrup, C; Krogsgaard-Larsen, P; Nielsen, M1
Dafny, N; Enna, SJ; Reyes-Vazquez, C1
Shavrin, AS; Zharkovskaia, TA; Zharkovskiĭ, AM1
Apud, JA; Masotto, C; Racagni, G1
Alphs, LD; Ferraro, TN; Hare, TA; Lafferman, J; Tamminga, CA; Thaker, GK1
Audi, EA; Graeff, FG1
Chweh, AY; Swinyard, EA; Wolf, HH1
Lindgren, S1
Zharkovskaia, TA; Zharkovskiĭ, AM1
DaSilva, AM; Gatti, PJ; Gillis, RA1
Enna, SJ; Zorn, SH2
Gillis, RA; Hamosh, P; Hartley, B; Quest, JA; Taveira da Silva, AM1
Chapman, AG1
Löscher, W2
Brunner, EA; Cheng, SC1
Friberg, L; Roland, PE1
Drower, EJ; Hammond, DL2
Pelley, KA; Vaught, JL1
Zarkovsky, AM1
Liebeskind, JC; Morgan, MM; Stein, C1
Jørgensen, OS; Meier, E; Schousboe, A1
Itoh, Y; Nishibori, M; Oishi, R; Saeki, K1
Ford, I; Kelly, PA; McCulloch, J1
Bennett, JP; Cruz, CJ; Ferrari, MB1
Beart, PM; Lloyd, KG; Scatton, B1
Bloss, JL; Hammond, DL1
Sawynok, J1
Ben-Ari, Y; Cherubini, E; Rovira, C1
Meldrum, B1
Maksay, G; Ticku, MK2
Minchin, MC; Nutt, DJ1
Jensen, MS; Lambert, JD1
Arnt, J; Christensen, AV1
Bauer, B1
Casey, DE; Gerlach, J; Hetmar, O; Kaldan, B; Korsgaard, S; Mikkelsen, LB1
Forchetti, MC; Guidotti, A; Krogsgaard-Larsen, P; Moroni, F1
Persson, B1
Drejer, J; Meier, E; Schousboe, A1
Chase, TN; Denaro, A; Foster, NL; Hare, TA; Tamminga, CA1
Cross, AJ; Waddington, JL1
Benson, DI; Klepner, CA; Squires, RF1
Krogsgaard-Larsen, P1
Kelly, PA; McCulloch, J2
Aaes-Jørgensen, T; Bøgesø, KP; Krogsgaard-Larsen, P; Mikkelsen, H; Schultz, B1
Carmona, E; Gomes, C; Trolin, G1
Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K1
Falch, E; Krogsgaard-Larsen, P1
Blavet, N; Clostre, F; DeFeudis, FV1
Blavet, N; Clostre, F; De Feudis, FV1
Wood, PL1
Dias Souza, J; Gillis, RA; Quest, JA; Williford, DJ1
Curtis, DR; Hjeds, H; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ1
Dutton, GR; Freedman, EG; Pearce, BR1
Breese, GR; Frye, GD1
Saederup, E; Squires, RF1
Christensen, AV; Krogsgaard-Larsen, P; Svendsen, O1
Blavet, N; DeFeudis, FV1
Mondrup, K; Pedersen, E1
Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ1
Breese, GR; Frye, GD; McCown, TJ1
Madtes, P; Redburn, DA1
Johnston, GA; Skerritt, JH1
Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ1
Deisz, RA; Dose, M1
Appel, JB; Holohean, AM; Nielsen, EB; Valentine, JD1
Costa, LG; Murphy, SD1
Bloch, R; Bousquet, P; Feldman, J; Schwartz, J1
Dafny, N; Reyes-Vázquez, C1
Bank-Mikkelsen, OK; Valentin, N1
Bjørndal, N; Casey, DE; Christensson, E; Gerlach, J1
Frey, HH; Löscher, W; Reiche, R; Schultz, D1
Hoehn-Saric, R1
Altmann, H; Dose, M; Emrich, HM; von Zerssen, D1
Hare, TA; Tamminga, CA; Thaker, GK1
Bjørndal, N; Christensson, E; Gerlach, J1
Di Scala, G; Karli, P; Schmitt, P2
Fariello, RG; Golden, GT1
Baumeister, AA; Frye, GD1
DeFeudis, FV1
Kjaer, M; Nielsen, H1
Følsgård, S; Jacobsen, E; Lindeburg, T; Madsen, SM; Sillesen, H1
DeFeudis, FV; Grognet, A; Hertz, F3
Agnoli, A; Chase, TN; Denaro, A; Ruggieri, S; Tamminga, CA1
Mueller, AL; Schwartzkroin, PA; Taube, JS1
Macdonald, RL; Skerritt, JH1
Horton, R; Meldrum, B1
Coward, DM1
Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H1
Andree, T; Enna, SJ; Kendall, DA1
Dam, M; Jensen, I; Petersen, HR1
Cheney, DL; McGill, W; Murray, TF1
Madsen, SM1
Maugh, TH1
Cagiano, R; Cuomo, V; Mocchetti, I; Racagni, G1
Alger, BE; Nicoll, RA1
Christensen, AV; Larsen, JJ1
Buescher, HH; Hill, RC; Maurer, R; Roemer, D1
Kuhar, MJ; London, ED; Palacios, JM; Rapoport, SI1
Magelund, G; Scheel-Krüger, J1
Ashton, D; Geerts, R; Leysen, JE; Waterkeyn, C1
Menon, MK1
Aaes-Jørgensen, T; Bøgesø, KP; Jørgensen, A; Schultz, B1
Clark, WG; Menon, MK; Vivonia, C1
Hruska, RE; Walters, JR; Waszczak, BL1
Walters, JR; Waszczak, BL1
Delorey, TM; Endo, S; Huh, KH; Olsen, RW1
Belhage, B; Elster, L; Fritschy, JM; Hansen, GH; Möhler, H; Schousboe, A1
Brehm, L; Falch, E; Frølund, B; Hansen, AB; Kristiansen, U; Krogsgaard-Larsen, P1
Cinotti, L; Froment, JC; Galy, G; Garcia-Larrea, L; Krogsgaard-Larsen, P; Landais, P; Lavenne, F; Le Bars, D; Millet, P; Peyron, R2
Elster, L; Saederup, E; Schousboe, A; Squires, RF1
Damgaard, I; Elster, L; Kardos, J; Krogsgaard-Larsen, P; Schousboe, A1
Abraham, JH; Schousboe, A; Seiler, N1
Ebert, B; Kemp, JA; Krogsgaard-Larsen, P; Wafford, KA; Whiting, PJ1
Anderson, CA; Faingold, CL; Randall, ME1
Kim, HY; Olsen, RW; Sapp, DW; Tobin, AJ1
Amit, Z; Boyle, AE; Segal, R; Smith, BR1
Buur, JR; Hjeds, H; Jørgensen, FS; Krogsgaard-Larsen, P1
Barnes, EM; Calkin, PA1
Batini, C; Billard, JM; Vigot, R1
Bapna, JS; Ramaswamy, S; Thirugnanasambantham, P; Viswanathan, S1
Abraham, JH; Hansen, GH; Schousboe, A; Seiler, N1
Barnes, EM; Tehrani, MH1
Morishita, W; Sastry, BR1
Faulhaber, J; Lancel, M1
Baylis, HA; Buckingham, SD; Hosie, AM; Matsuda, K; Sattelle, DB; Squire, MD1
Alger, BE; Kirov, SA; Lenz, RA; Martin, LA; Morishita, W; Pitler, TA1
Matsutani, S; Yamamoto, N1
Faulhaber, J; Lancel, M; Steiger, A1
Agmo, A; Highland, L; Karam, P; Paredes, RG1
Ebert, B; Krogsgaard-Larsen, P; McKernan, R; Saounatsou, K; Thompson, SA; Wafford, KA1
Hetzler, BE; Zeisset, HL1
Geter-Douglass, B; Tirelli, E; Witkin, JM1
Aleo, MD; Miller, GW; Schnellmann, RG; Waters, SL1
Belhage, B; Carlson, BX; Elster, L; Hansen, GH; Olsen, RW; Schousboe, A1
Lancel, M1
Kulinskiĭ, VI; Mikhel'son, GV2
Damgaard, I; Rodríguez-Farré, E; Schousboe, A; Suñol, C; Vale, C1
Bedingfield, JB; Calder, LD; Karler, R; Thai, DK1
Eriksson, B; Magnusson, AK; Tham, R1
Agmo, A; Contreras, JL; Paredes, RG1
Dzubay, JA; Jones, MV; Sahara, Y; Westbrook, GL1
Broadbent, J; Harless, WE1
Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA1
Faingold, CL; N'Gouemo, P1
Asnis, N; Barros, HM; Gomez, R; Tannhauser, SL1
Burgard, EC; Haas, KF; Macdonald, RL1
Firestone, LL; Hammond, DL; Homanics, GE; Ugarte, SD1
Lancel, M; Langebartels, A1
Maksay, G; McKernan, R1
Allikmets, L; Matto, V; Pruus, K; Rudissaar, R; Skrebuhhova-Malmros, T1
Ebert, B; Fjalland, B; Hansen, SL; Kristiansen, U1
Lancel, M; Mathias, S; Steiger, A; Wetter, TC1
Lancel, M; Mathias, S; Steiger, A1
Jonas, P; Jones, MV; Sahara, Y; Westbrook, GL1
de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Hokoç, JN; Loureiro dos Santos, NE; Yamasaki, EN1
Hong, JT; Lee, MK; Oh, KW; Shin, IC; Yoon, IS1
Ebert, B; Frølund, B; Kristiansen, U; Krogsgaard-Larsen, P; Liljefors, T1
Ebert, B; Frølund, B; i Storustovu, S; Mortensen, M1
Brünig, I; Fritschy, JM; Studler, B1
Platt, B; White, AM1
Frølund, B; Krogsgaard-Larsen, P; Liljefors, T1
Alva, H; Blednov, YA; Harris, RA; Jung, S; Rosahl, T; Wallace, D; Whiting, PJ1
Gong, QH; Gulinello, M; Smith, SS1
Ebert, B; Stórustovu, Sí2
Kristensen, BW; Noraberg, J; Zimmer, J1
Birnir, B; Ebert, B; Lindquist, CE1
Birnir, B; Lindquist, CE; Smith, M1
Chebib, M; Ebert, B; Frølund, B; Johnston, GA; Krehan, D; Krogsgaard-Larsen, P; Nielsen, B1
Ebert, B; Michelsen, S; Sanchez, C; Voss, J1
Frosini, M; Sgaragli, G; Valoti, M1
Beyer, C; García-Juárez, M; González-Flores, O; González-Mariscal, G; Lima-Hernández, FJ; Sánchez, N1
Hansen, SL; Sánchez, C; Sperling, BB1
Blednov, YA; Boehm, SL; Harris, RA; Peden, L1
Cagetti, E; Liang, J; Olsen, RW; Spigelman, I1
Babich, M; Branda, EM; Elfline, GS; Quock, RM1
Huckle, R1
Ebert, B; Frølund, B; Krogsgaard-Larsen, P; Liljefors, T1
Barry, PH; Carland, JE; Chebib, M; Johnston, GA; Moorhouse, AJ1
Lancel, M; Mathias, S; Steiger, A; Zihl, J1
Fritschy, JM; Sidler, C; van Rijnsoever, C1
France, CP; McMahon, LR1
Bösch, G; Kopp, C; Tobler, I; Vyazovskiy, VV1
Abílio, VC; Araujo, NP; Castro, JP; Faria, RR; Frussa-Filho, R; Fukushiro, DF; Medrano, WA; Peixoto, MF; Silva, RH; Zanier-Gomes, PH1
Chan, GC; Maas, JW; Muglia, LJ; Pineda, VV; Storm, DR; Vogt, SK1
Bjerrum, OJ; Blackburn-Munro, G; Jensen, DG; Rode, F1
Gong, QH; Shen, H; Smith, SS; Yuan, M1
Biggio, F; Biggio, G; Busonero, F; Caria, S; Follesa, P; Gorini, G; Mostallino, MC; Mura, ML; Murru, L; Sanna, E1
Goldstein, PA; Harrison, NL; Jia, F; Pignataro, L; Schofield, CM; Yue, M1
Drasbek, KR; Jensen, K1
Ebert, B; Wafford, KA1
Korpi, ER; Möykkynen, T; Ranna, M; Sinkkonen, ST; Uusi-Oukari, M1
Jia, H; Qu, CL; Tang, JS1
Gartside, SE; Ingram, CD; Judge, SJ; Kaura, V; Young, AH1
Blednov, YA; Boehm, SL; Harris, RA; Homanics, GE1
Steiger, A1
Airaksinen, MS; Kulesskaya, N; Segerstråle, M; Taira, T; Tornberg, J; Voikar, V1
Chandra, D; Harrison, NL; Homanics, GE; Houser, CR; Jia, F; Liang, J; Olsen, RW; Peng, Z; Spigelman, I; Suryanarayanan, A; Werner, DF1
Davies, M; Derry, JM; Dunn, SM; Paulsen, IM1
Allgaier, C; Rassler, C; Strecker, K; Wegner, F; Wohlfarth, K1
Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD2
Drasbek, KR; Hoestgaard-Jensen, K; Jensen, K1
Ebert, B; Michelsen, S; Sánchez, C1
Cremers, T; Ebert, B1
Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M1
Homanics, GE; Tobler, I; Vyazovskiy, VV; Winsky-Sommerer, R1
Deacon, S; Legters, A; Loft, H; Lundahl, J; Staner, C; Staner, L1
Park, JB; Skalska, S; Son, S; Stern, JE1
Deacon, S; Dijk, DJ; Lundahl, J; Walsh, JK1
Orser, BA1
Deacon, S; Loft, H; Lundahl, J; Staner, C; Staner, L1
Brust, P; Deuther-Conrad, W; Ebert, B; Friemel, A; Hutson, PH; Nieber, K1
Boehm, SL; Goldfarb, KJ; Linsenbardt, DN; Moore, EM; Serio, KM; Stepanovska, S1
Deacon, S; Guico-Pabia, C; Martinez, R; Mayleben, D; Vandormael, K; Walsh, JK1
Dige, T; Fu, I; Jørgensen, M; Kall, MA; Vallano, P; Woolf, E1
Korpi, ER; Linden, AM; Lüddens, H; Möykkynen, T; Rabe, H; Ranna, M; Saarelainen, KS; Sinkkonen, ST; Uusi-Oukari, M1
Belelli, D; Haythornthwaite, AR; Herd, MB; Homanics, GE; Lambert, JJ; Rosahl, TW; Wafford, KA1
Harrison, NL; Keramidas, A1
Adrien, J; Aixendri, R; Alexandre, C; Dordal, A; Guzman, A; Hamon, M1
Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V1
McCarley, RW; Thakkar, MM; Winston, S1
Dósa, Z; Drasbek, KR; Jensen, K; Vardya, I1
Huntsman, MM; Krook-Magnuson, EI; Li, P; Paluszkiewicz, SM1
Volgin, DV1
Dickey, P; Eisenstein, R; Feren, SD; Griffin, K; Groeger, J; Hall, J; Randazzo, AC; Schweitzer, PK; Snyder, E; Walsh, JK1
Amar, M; Baux, G; Fossier, P; Le Roux, N; Moreau, A1
Akabas, MH; Dannhardt, G; Debus, F; Dieler, S; Jansen, M; Lüddens, H; Rabe, H; Strehle, A1
Ahring, PK; Erichsen, HK; Larsen, JS; Lopez-Garcia, JA; Mirza, NR; Munro, G; Nielsen, EØ; Rivera-Arconada, I1
Corser, BC; Deacon, S; Lankford, DA; Li, Z; Lines, CR; Snavely, DB; Zheng, YP1
Boyle, J; Cerchio, K; Cummings, C; Gargano, C; Lines, C; McCrea, J; Wolford, D1
Anari, MR; Braun, MP; Cai, X; Chu, XY; Cuevas-Licea, K; Doss, GA; Evers, R; Kassahun, K; Liang, Y; Rippley, RK; Shou, M1
Agrawal, N; Alexander, R; Boyle, J; Calder, N; Danjou, P; Fu, I; Gargano, C; McCrea, JB; Murphy, MG1
Cremers, TI; De Lange, EC; de Vries, MG; Ebert, B; Huinink, KD; v d Hart, M; van Loon, JP; Westerink, BH1
Cook, JM; Groenink, L; Hopkins, SC; Klanker, M; Korte, SM; Olivier, B; Van Linn, ML; Vinkers, CH1
Ehlen, JC; Paul, KN1
Balfour, DJ; Belelli, D; Brown, VJ; Chandra, D; Foister, N; Herd, MB; Homanics, GE; Lambert, JJ; Peden, DR1
Eglin, M; Hajak, G; Hedner, J; Loft, H; Lundahl, J; Lütolf, S; Stórustovu, SI1
Kositsyn, NS; Shul'gina, GI; Zyablitseva, EA1
Darbra, S; Pallarès, M1
Deacon, S; Dijk, DJ; James, LM; Peters, S; Walsh, JK1
Gartside, SE; Griffith, NC; Ingram, CD; Kaura, V1
Leufkens, TR; Lund, JS; Vermeeren, A1
Brodin, B; Holm, R; Jensen, KG; Larsen, M; Nielsen, CU1
Baur, R; Kaur, KH; Sigel, E1
Brodin, B; Holm, R; Jensen, KG; Larsen, M; Nielsen, CU; Sveigaard, C1
Chesnoy-Marchais, D1
Walsh, JK1
Blednov, YA; Harris, AR; Homanics, G; Iyer, SV; Walker, DL1
Henningsen, K; Holm, MM; Jayatissa, MN; Jensen, K; Nieto-Gonzalez, JL; Vardya, I; Wiborg, O1
Ebert, B; Mortensen, M; Smart, TG; Wafford, K1
Anderson, D; Ceesay, P; Lines, C; Roth, T; Snavely, D; Vandormael, K1
Kelly, KM; Kharlamov, EA; Lepsveridze, E; Lu, B; Mtchedlishvili, Z; Xu, H1
Leopold, DA; Mishkin, M; Smith, K; Turchi, J; Wilke, M1
Corbin, JG; Huntsman, MM; Kaufmann, WE; Martin, BS; Olmos-Serrano, JL; Paluszkiewicz, SM1
Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J1
Damgaard, T; Hansen, SL; Neill, JC; Plath, N1
Deacon, S; Ebert, B; Ferri, R; Ma, J; Ray, S; Snyder, E; Svetnik, V; Walsh, JK1
Frølund, S; Nielsen, CU; Rapin, N1
Mozrzymas, JW; Urban-Ciecko, J1
Caspary, DM; Ling, LL; Richardson, BD; Uteshev, VV1
Bonin, RP; De Koninck, Y; Eng, DG; Labrakakis, C; Orser, BA; Whissell, PD1
Ayissi Mbomo, R; Gartside, S; McQuade, R; Ngo Bum, E; Njikam, N; Okello, E1
Clausen, RP; Ebert, B; Krogsgaard-Larsen, P; Madsen, KK; Schousboe, A; White, HS1
Dempster, J; Head, SI; Kueh, SL; Morley, JW1
Finn, DA; Ford, MM; Fretwell, AM; Ramaker, MJ1
Meera, P; Otis, TS; Wallner, M1
Chang, S; Cook, JM; Emala, CW; Gallos, G; Gerthoffer, WT; Xu, D; Yim, P; Zhang, Y1
Deacon, S; Dijk, DJ; Groeger, JA; Legters, A; Lundahl, J; Stanley, N; Trap Huusom, AK1
Deacon, S; Dijk, DJ; Ma, J; Ray, S; Svetnik, V; Tymofyeyev, Y; Walsh, JK1
Ebert, B; Kasper, S; Larsen, K; Tonnoir, B1
Deacon, S; Lundahl, J; Maurice, D; Staner, L1
Burns, MP; Corbin, JG; Olmos-Serrano, JL1
Dretchen, KL; Gillis, RA; Herman, MA; Sahibzada, N; Vicini, S1
Gartside, SE; McCardle, CE1
Charbonnet, M; Gold, MS; Lee, KY1
Bétry, C; Christensen, T; Ebert, B; Etievant, A; Haddjeri, N; Mnie-Filali, O; Wiborg, O1
Barberis, A; Benfenati, F; Cancedda, L; Fiumelli, H; Succol, F1
Aitta-aho, T; Ator, NA; Ebert, B; Korpi, ER; Panhelainen, A; Vashchinkina, E; Vekovischeva, OY1
Asiedu, MN; Kaila, K; Malan, TP; Mejia, G; Ossipov, MK; Price, TJ1
Gielen, MC; Lumb, MJ; Smart, TG1
Broberg, Ml; Brodin, B; Christensen, KV; Ewon, KB; Frølund, S; Holm, R; Jensen, A; Kall, MA; Nielsen, Al; Nielsen, CU; Tønsberg, H1
Boddum, K; Dalby, NO; Dósa, Z; Ebert, B; Hoestgaard-Jensen, K; Holm, MM; Jensen, K; Jones, KA; Nieto-Gonzalez, JL; Vardya, I; Wolinsky, TD1
Abbassi, L; Denbow, DM; Jonaidi, H; Kaiya, H; Kamali, Y; Shojaei, B; Yaghoobi, MM1
Finn, DA; Ford, MM; Ramaker, MJ; Strong, MN1
Frølund, S; Holm, R; Kall, MA; Langthaler, L; Nielsen, CU1
Branco, T; Chadderton, P; Duguid, I; Häusser, M; London, M1
Ishibashi, H; Nabekura, J; Nielsen, M; Witt, MR1
Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M1
Baghdoyan, HA; Vanini, G1
Andersen, RA; Kagan, I; Wilke, M1
Chen, G; Jiang, D; Kong, S; Pitre, A; Sun, Y; Wang, Y; Wu, Z1
Lecker, I; Orser, BA; Rosenzweig, S; Wang, DS; Whissell, PD; Wojtowicz, JM1
France, CP; Gerak, LR1
Abdulhadi, S; Brodin, B; Frølund, S; Holm, R; Kall, MA; Langthaler, L; Nielsen, CU; Nøhr, MK; Sari, H1
Karakossian, MH; Meera, P; Otis, TS; Santhakumar, V1
Eng, D; Lecker, I; Martin, LJ; Orser, BA; Wang, DS; Whissell, PD1
Caspary, DM; Duque, D; Malmierca, MS1
Brozoski, TJ; Cai, R; Caspary, DM; Kalappa, BI; Ling, LL1
Bond, AD; Koradia, V; Lopez de Diego, H1
Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG1
Blomquist, SL; Diaz, MR; Everett, JC; Morton, RA; Orser, BA; Valenzuela, CF; Vollmer, CC; Vollmer, W; Yu, J; Zamudio-Bulcock, PA; Zurek, AA1
Luo, R; Partridge, JG; Vicini, S1
Dvorzhak, A; Grantyn, R; Semtner, M; Wójtowicz, AM1
Alò, R; Avolio, E; Canonaco, A; Canonaco, M; Carelli, A; Mele, M; Storino, F1
Brazhe, A; Jensen, K; Jessen, SB; Lauritzen, M; Lind, BL; Mathiesen, C; Thomsen, K1
Marowsky, A; Vogt, KE1
Gong, QH; Smith, SS1
Bavley, RL; Blomstrom, KJ; Fomalont, K; Mitz, AR; Murray, EA; Rudebeck, PH; Turchi, J; Yang, T1
Finn, DA; Ford, MM; Phillips, TJ; Ramaker, MJ1
Corbin, JG; Huntsman, MM; Martin, BS1
Gangadharan, G; Hwang, EM; Lee, B; Lee, S; Paydar, A; Shin, HS1
Baldelli, P; Benfenati, F; Ferrea, E; Greco, B; Medrihan, L1
Boehm, SL; Fritz, BM1
Lingford-Hughes, A; Muthukumaraswamy, S; Myers, J; Nutt, D; Papadopoulos, A; Wilson, S1
Herring, WJ; Lines, C; Ma, J; Roth, T; Snyder, E; Svetnik, V1
Cheng, L; Dargham, RA; Kong, S; Liu, X; Ren, W; Wan, L; Wang, Y; Wu, Z1
Finn, DA; Ford, MM; Phillips, TJ; Ramaker, MJ; Strong-Kaufman, MN1
Babateen, O; Bhandage, A; Birnir, B; Forsberg Nilsson, K; Jin, Z; Korol, SV; Smits, A; Uhrbom, L; Westermark, B1
Hellsten, KS; Korpi, ER; Linden, AM1
Brooks-Kayal, A; Carlsen, J; Cea-Del Rio, CA; Cruz Del Angel, Y; González, MI; Grabenstatter, HL; Huntsman, MM; Laoprasert, RP; White, AM1
Angadi, V; Dissel, S; Donlea, J; English, D; Kirszenblat, L; Klose, M; Koch, Z; Shaw, PJ; Suzuki, Y; van Swinderen, B; Winsky-Sommerer, R1
Bondy, B; Cui, N; Jiang, C; Jin, X; Johnson, CM; Oginsky, MF; Wu, Y; Zhang, S; Zhong, W1
Boychuk, CR; Halmos, KC; Smith, BN1
Berry, JA; Cervantes-Sandoval, I; Chakraborty, M; Davis, RL1
Chen, HJ; Corcoran, KA; Guedea, AL; Jovasevic, V; Leaderbrand, K; Radulovic, J; Shepherd, GM; Yamawaki, N1
Balakrishnan, A; Kesisoglou, F; Manser, K1
Bohnsack, JP; Carlson, SL; Morrow, AL; Patel, V1
Kuver, A; Smith, SS1
Holm, R; Lagunas, C; Nielsen, CU; Plum, J; Rasmussen, RN1
Cetina, Y; Houser, CR; Huang, CS; Otis, TS; Peng, Z; Tong, X; Wallner, M; Zhang, N1
Boychuk, JA; Butler, CR; Halmos, KC; Smith, BN1
Boehm, SL; Quoilin, C1
Gerak, LR; Ibarra, MH; Pressly, JD; Smith, KR; Zanettini, C1
Astafurov, K; Dow-Edwards, D; Nestler, EJ; Popp, S; Silverman, NS; Vialou, V1
Boychuk, JA; Butler, CR; Smith, BN1
Absalom, NL; Ahring, PK; Chebib, M; Hanrahan, JR; Lee, HJ; van Nieuwenhuijzen, P1
Merlin, LR; Shen, H; Smith, SS; Yang, L1
Finn, DA; Helms, M; Jensen, J; Kaplan, JS; Nipper, MA; Richardson, BD; Rossi, DJ1
Johnston, GAR1
Cui, N; Jiang, C; Johnson, CM; Wu, Y; Xing, H; Zhong, W1
Chaussenot, R; Vaillend, C1
Cai, J; Chen, RX; Liao, FF; Liu, FY; Wan, Y; Wang, J; Xu, FQ; Yi, M; Zhang, C; Zhang, Y1
Afroz, S; Shen, H; Smith, SS1
Browning, KN; McMenamin, CA; Travagli, RA1
Babapour, V; Hashemzadeh, M; Panahi, N; Zendehdel, M1
Grabowska, MJ; Jeans, R; Paulk, AC; Rohrscheib, C; Shaw, PJ; Troup, M; van Alphen, B; van Swinderen, B; Yap, MHW1
Duan, XL; He, YT; Hu, XD; Liu, JP; Suo, ZW; Yang, X1
Burton, EA; Scheetz, SD; Shao, E; Xie, W1
Alabed, S; Bergman, H; Latifeh, Y; Mohammad, HA1
Crawley, JN; Kazdoba, TM; Parrott, JM; Rhine, MA; Schultz, MN1
Dannenhoffer, CA; Spear, LP1
Herring, WJ; Lines, C; Roth, T; Snyder, ES; Svetnik, V; Tao, P1
Eisold, A1
Herberholz, J; Pena-Flores, NL; Venuti, LS1
Bird, LM; Burdine, RD; During, MJ; Heimer, G; Holcroft, C; Kolevzon, A; Melmed, RD; Ochoa-Lubinoff, C; Rakhit, A; Tan, WH; Thibert, RL; Visootsak, J1
Jovasevic, V; Radulovic, J1
Copping, NA; Fink, KD; McTighe, SM; Silverman, JL1

Reviews

21 review(s) available for isoxazoles and gaboxadol

ArticleYear
GABAA agonists as targets for drug development.
    Clinical and experimental pharmacology & physiology, 1992, Volume: 19, Issue:1

    Topics: Acetates; Acrylates; Amines; Analgesics; Anthelmintics; Anticonvulsants; Bicuculline; Computer Simulation; Cyclohexanecarboxylic Acids; Cyclopentanes; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Molecular Weight; Receptors, GABA-A

1992
Pharmacological models of generalized absence seizures in rodents.
    Journal of neural transmission. Supplementum, 1992, Volume: 35

    Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rodentia; Sodium Oxybate; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1992
Drugs acting on amino acid neurotransmitters.
    Advances in neurology, 1986, Volume: 43

    Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid

1986
Heterocyclic analogues of GABA: chemistry, molecular pharmacology and therapeutic aspects.
    Progress in medicinal chemistry, 1985, Volume: 22

    Topics: Analgesics; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Nipecotic Acids; Receptors, GABA-A

1985
Valproate and myoclonus.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid

1986
Inhibitors of the GABA uptake systems.
    Molecular and cellular biochemistry, 1980, Jun-18, Volume: 31, Issue:2

    Topics: Animals; Astrocytes; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoxazoles; Muscimol; Neuroglia; Neurons; Nipecotic Acids; Receptors, Neurotransmitter; Structure-Activity Relationship; Synapses; Synaptosomes

1980
THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.
    Advances in biochemical psychopharmacology, 1981, Volume: 29

    Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Oxazoles; Pipecolic Acids; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution

1981
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
    Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1981, Volume: 35, Issue:5

    Topics: Agaricales; Amanita; Animals; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Structural; Molecular Conformation; Muscimol; Nipecotic Acids; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism

1981
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.
    Pharmaceutisch weekblad. Scientific edition, 1982, Oct-22, Volume: 4, Issue:5

    Topics: Analgesics; Animals; Brain; gamma-Aminobutyric Acid; Humans; Isoxazoles; Methylphenidate; Neurons; Oxazoles; Stereotyped Behavior; Synaptic Transmission

1982
Molecular pharmacology of the GABA receptors and GABA agonists.
    Advances in biochemical psychopharmacology, 1983, Volume: 37

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Humans; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism; Synapses

1983
GABA system: clinical research and treatment of tardive dyskinesia.
    Modern problems of pharmacopsychiatry, 1983, Volume: 21

    Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin

1983
GABA(A) receptor ligands and their therapeutic potentials.
    Current topics in medicinal chemistry, 2002, Volume: 2, Issue:8

    Topics: Animals; Central Nervous System Diseases; GABA Agents; GABA Agonists; GABA Antagonists; Humans; Isonicotinic Acids; Isoxazoles; Ligands; Muscimol; Piperidines; Protein Subunits; Receptors, GABA-A

2002
Medicinal chemistry and molecular pharmacology of GABA(C) receptors.
    Current topics in medicinal chemistry, 2002, Volume: 2, Issue:8

    Topics: Amino Acids, Cyclic; Animals; Barbiturates; Crotonates; GABA Agonists; GABA Antagonists; Imidazoles; Isoxazoles; Muscimol; Organophosphorus Compounds; Phosphinic Acids; Pyridines; Receptors, GABA; Receptors, GABA-A

2002
Specific GABA(A) agonists and partial agonists.
    Chemical record (New York, N.Y.), 2002, Volume: 2, Issue:6

    Topics: Benzodiazepines; GABA Agonists; GABA-A Receptor Agonists; Humans; Isoxazoles; Nervous System; Neurotransmitter Agents; Receptors, GABA-A; Steroids

2002
Gaboxadol--a new awakening in sleep.
    Current opinion in pharmacology, 2006, Volume: 6, Issue:1

    Topics: Animals; Benzodiazepines; Clinical Trials as Topic; Drug Interactions; Ethanol; GABA Agonists; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Receptors, GABA-A; Sleep; Sleep Initiation and Maintenance Disorders; Thalamus

2006
Neurochemical regulation of sleep.
    Journal of psychiatric research, 2007, Volume: 41, Issue:7

    Topics: Brain; Corticotropin-Releasing Hormone; Electroencephalography; Estrogens; GABA Agonists; GABA-A Receptor Agonists; Growth Hormone-Releasing Hormone; Hormone Replacement Therapy; Humans; Hypnotics and Sedatives; Hypothalamo-Hypophyseal System; Isoxazoles; Neuropeptides; Nipecotic Acids; Pituitary-Adrenal System; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tiagabine

2007
Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2006, Apr-15, Volume: 2, Issue:2

    Topics: Brain; GABA Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Receptors, GABA-A; Sleep Initiation and Maintenance Disorders; Synapses

2006
Enhancement of slow wave sleep: implications for insomnia.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2009, Apr-15, Volume: 5, Issue:2 Suppl

    Topics: Electroencephalography; GABA Agonists; Humans; Isoxazoles; Nipecotic Acids; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tiagabine

2009
GABA Australis, some reflections on the history of GABA receptor research in Australia.
    Pharmacological research, 2017, Volume: 116

    Topics: Animals; Australia; Baclofen; Bicuculline; Cyclic AMP; Humans; Isoxazoles; Muscimol; Receptors, GABA

2017
Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia.
    The Cochrane database of systematic reviews, 2018, 04-17, Volume: 4

    Topics: Antipsychotic Agents; Baclofen; Dyskinesia, Drug-Induced; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Placebos; Randomized Controlled Trials as Topic; Valproic Acid

2018
Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, Volume: 18, Issue:3

    Topics: Angelman Syndrome; Animals; Anticonvulsants; Biological Products; Genetic Therapy; Humans; Isoxazoles; Neurodevelopmental Disorders; Recombinant Fusion Proteins; RNA, Antisense; Ubiquitin-Protein Ligases

2021

Trials

34 trial(s) available for isoxazoles and gaboxadol

ArticleYear
GABA-agonist therapy for Alzheimer's disease.
    Clinical neuropharmacology, 1986, Volume: 9, Issue:3

    Topics: Alzheimer Disease; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Isoxazoles; Middle Aged; Neuropsychological Tests; Oxazoles; Somatostatin

1986
Brain gamma-aminobutyric acid abnormality in tardive dyskinesia. Reduction in cerebrospinal fluid GABA levels and therapeutic response to GABA agonist treatment.
    Archives of general psychiatry, 1987, Volume: 44, Issue:6

    Topics: Adult; Aminocaproates; Brain; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Receptors, GABA-A; Schizophrenia; Vigabatrin

1987
The effect of tetrahydroisoxazolopyridinol (THIP) in tardive dyskinesia: a new gamma-aminobutyric acid agonist.
    Archives of general psychiatry, 1982, Volume: 39, Issue:9

    Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Blinking; Clinical Trials as Topic; Confusion; Dizziness; Dyskinesia, Drug-Induced; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Oxazoles; Parkinson Disease, Secondary; Placebos; Vomiting

1982
THIP treatment of Huntington's disease.
    Neurology, 1983, Volume: 33, Issue:5

    Topics: Adult; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Female; Homovanillic Acid; Humans; Huntington Disease; Isoxazoles; Male; Middle Aged; Oxazoles

1983
Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Halothane; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Respiration

1983
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid

1983
GABA system: clinical research and treatment of tardive dyskinesia.
    Modern problems of pharmacopsychiatry, 1983, Volume: 21

    Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin

1983
THIP: a single-blind controlled trial in patients with epilepsy.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:2

    Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles

1983
Analgesic from mushrooms begins clinical trials.
    Science (New York, N.Y.), 1981, Apr-24, Volume: 212, Issue:4493

    Topics: Analgesics; Clinical Trials as Topic; Humans; Isoxazoles; Oxazoles

1981
Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activation.
    Epilepsy research, 1994, Volume: 19, Issue:1

    Topics: Adult; Behavior; Brain; Epilepsy, Temporal Lobe; Female; Fluorine Radioisotopes; GABA Agonists; Glucose; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Radioligand Assay; Receptors, GABA-A; Reference Values; Tomography, Emission-Computed

1994
Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TL
    Epilepsy research, 1994, Volume: 19, Issue:1

    Topics: Adult; Brain; Epilepsy, Temporal Lobe; Female; Fluorine Radioisotopes; GABA Agonists; Glucose; Humans; Isoxazoles; Male; Middle Aged; Radioligand Assay; Receptors, GABA-A; Reference Values; Tomography, Emission-Computed

1994
The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans.
    Psychopharmacology, 1997, Volume: 130, Issue:3

    Topics: Adult; Double-Blind Method; GABA Agonists; Humans; Isoxazoles; Male; Receptors, GABA-A; Sleep Stages; Sleep, REM

1997
The GABA(A) agonist gaboxadol improves the quality of post-nap sleep.
    Psychopharmacology, 2001, Volume: 157, Issue:3

    Topics: Adult; Electroencephalography; GABA Agonists; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Polysomnography; Sleep; Sleep Stages

2001
Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Activities of Daily Living; Aged; Attention; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Electroencephalography; Female; GABA Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Memory; Middle Aged; Neuropsychological Tests; Placebo Effect; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Wakefulness

2005
Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia.
    Sleep, 2007, Volume: 30, Issue:3

    Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Neuropsychological Tests; Polysomnography; Sleep Initiation and Maintenance Disorders

2007
The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia.
    Sleep, 2007, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Cross-Over Studies; Delta Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Middle Aged; Polysomnography; Pyridines; Sleep; Sleep, REM; Theta Rhythm; Wakefulness; Zolpidem

2007
Short-term treatment with gaboxadol improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomnia.
    Psychopharmacology, 2007, Volume: 195, Issue:1

    Topics: Adolescent; Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electroencephalography; GABA Agonists; Headache; Humans; Isoxazoles; Middle Aged; Nausea; Polysomnography; Pyridines; Sex Factors; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tachycardia; Time Factors; Treatment Outcome; Zolpidem

2007
Efficacy of the selective extrasynaptic GABA A agonist, gaboxadol, in a model of transient insomnia: a randomized, controlled clinical trial.
    Sleep medicine, 2008, Volume: 9, Issue:4

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Receptors, GABA; Sleep Initiation and Maintenance Disorders; Wakefulness

2008
Slow wave sleep enhancement with gaboxadol reduces daytime sleepiness during sleep restriction.
    Sleep, 2008, Volume: 31, Issue:5

    Topics: Adult; Affect; Arousal; Attention; Circadian Rhythm; Disorders of Excessive Somnolence; Double-Blind Method; Electroencephalography; Epinephrine; Fatigue; Female; Fourier Analysis; GABA Agonists; Humans; Hydrocortisone; Isoxazoles; Male; Mental Recall; Neuropsychological Tests; Norepinephrine; Polysomnography; Psychomotor Performance; Reaction Time; Sleep; Sleep Deprivation

2008
Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studies.
    Sleep, 2008, Volume: 31, Issue:10

    Topics: Adolescent; Adult; Age Factors; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Young Adult

2008
Next-day residual effects of gaboxadol and flurazepam administered at bedtime: a randomized double-blind study in healthy elderly subjects.
    Human psychopharmacology, 2009, Volume: 24, Issue:1

    Topics: Administration, Oral; Aged; Cross-Over Studies; Disorders of Excessive Somnolence; Double-Blind Method; Female; Flurazepam; GABA Agonists; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Mental Recall; Psychomotor Performance; Reaction Time; Surveys and Questionnaires; Time Factors

2009
Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:2

    Topics: Aged; Cross-Over Studies; Double-Blind Method; Female; Flicker Fusion; GABA Agonists; Humans; Isoxazoles; Male; Postural Balance; Pyridines; Reaction Time; Zolpidem

2009
A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients.
    Sleep medicine, 2009, Volume: 10, Issue:7

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Administration Schedule; Electronic Data Processing; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Pyridines; Severity of Illness Index; Single-Blind Method; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Surveys and Questionnaires; Time Factors; Treatment Outcome; Young Adult; Zolpidem

2009
Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Cross-Over Studies; Electroencephalography; Female; Humans; Hypnotics and Sedatives; Isoxazoles; Male; Middle Aged; Pyridines; Receptors, GABA-A; Sex Factors; Sleep; Sleep Stages; Sleep, REM; Young Adult; Zolpidem

2010
Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010, Feb-15, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; GABA Agonists; Humans; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Sex Characteristics; Sleep Initiation and Maintenance Disorders

2010
Alterations in cyclic alternating pattern associated with phase advanced sleep are differentially modulated by gaboxadol and zolpidem.
    Sleep, 2010, Volume: 33, Issue:11

    Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Female; GABA Agonists; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Pyridines; Self Report; Sleep Initiation and Maintenance Disorders; Sleep Stages; Young Adult; Zolpidem

2010
Enhanced slow wave sleep and improved sleep maintenance after gaboxadol administration during seven nights of exposure to a traffic noise model of transient insomnia.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:8

    Topics: Adult; Aged; Automobiles; Female; GABA-A Receptor Agonists; Humans; Isoxazoles; Male; Middle Aged; Noise, Transportation; Polysomnography; Self Report; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages

2012
EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Oct-15, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Sex Distribution; Sleep Initiation and Maintenance Disorders; Time Factors; Young Adult

2011
Combining escitalopram with gaboxadol provides no additional benefit in the treatment of patients with severe major depressive disorder.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; International Cooperation; Isoxazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult

2012
EEG spectral power density profiles during NREM sleep for gaboxadol and zolpidem in patients with primary insomnia.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:8

    Topics: Adolescent; Adult; Aged; Brain Waves; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Sedatives; Isoxazoles; Middle Aged; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Zolpidem

2012
Effects of pulvinar inactivation on spatial decision-making between equal and asymmetric reward options.
    Journal of cognitive neuroscience, 2013, Volume: 25, Issue:8

    Topics: Analgesics; Animals; Bias; Contrast Sensitivity; Decision Making; Functional Laterality; Isoxazoles; Macaca mulatta; Magnetic Resonance Imaging; Male; Memory; Movement; Neural Pathways; Reaction Time; Reward; Saccades; Space Perception; Visual Cortex

2013
Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers.
    Neuropharmacology, 2015, Volume: 88

    Topics: Adult; Brain; Brain Waves; Cross-Over Studies; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetoencephalography; Male; Nipecotic Acids; Pyridines; Rest; Single-Blind Method; Synapses; Tiagabine; Young Adult; Zolpidem

2015
Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.
    Sleep, 2014, Oct-01, Volume: 37, Issue:10

    Topics: Adult; Aged; Azepines; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Healthy Volunteers; Humans; Isoxazoles; Male; Middle Aged; Orexin Receptor Antagonists; Polysomnography; Pyridines; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Young Adult; Zolpidem

2014
The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman Syndrome.
    Neurology, 2021, 02-16, Volume: 96, Issue:7

    Topics: Adolescent; Adult; Angelman Syndrome; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Young Adult

2021

Other Studies

419 other study(ies) available for isoxazoles and gaboxadol

ArticleYear
Effects of GABA-mimetic agents on the cat spinal cord.
    Progress in neuro-psychopharmacology, 1979, Volume: 3, Issue:4

    Topics: Animals; Bicuculline; Cats; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Ibotenic Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neurons, Afferent; Spinal Cord

1979
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
    European journal of pharmacology, 1979, Oct-15, Volume: 58, Issue:4

    Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug

1979
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord.
    Journal of neurochemistry, 1978, Volume: 31, Issue:6

    Topics: Aminobutyrates; Animals; Biological Transport; Cats; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons; Nipecotic Acids; Oxazoles; Spinal Cord

1978
Muscimol and N,N-dimethylmuscimol: from a GABA agonist to a glycine antagonist.
    Journal of neuroscience research, 1992, Volume: 31, Issue:1

    Topics: Chemical Phenomena; Chemistry, Physical; Computer Simulation; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Structure-Activity Relationship

1992
Defense reaction elicited by microinjection of kainic acid into the medial hypothalamus of the rat: antagonism by a GABAA receptor agonist.
    Behavioral and neural biology, 1992, Volume: 57, Issue:3

    Topics: Agonistic Behavior; Animals; Anticonvulsants; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Exploratory Behavior; Hypothalamus, Middle; Isoxazoles; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Social Isolation

1992
First direct electron microscopic visualization of a tight spatial coupling between GABAA-receptors and voltage-sensitive calcium channels.
    Neuroscience letters, 1992, Mar-16, Volume: 137, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Calcium; Calcium Channels; Cells, Cultured; Cerebellar Cortex; Immunohistochemistry; Ion Channel Gating; Isoxazoles; Microscopy, Electron; Neurons; Rats; Receptors, GABA-A

1992
The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups.
    Brain research. Developmental brain research, 1992, Aug-21, Volume: 68, Issue:2

    Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Infusions, Parenteral; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Substantia Nigra

1992
Pharmacological study of the chicken's monocular optokinetic nystagmus: effects of GABAergic agonist and antagonists.
    Vision research, 1992, Volume: 32, Issue:4

    Topics: Animals; Bicuculline; Chickens; Electroretinography; Eye Movements; Injections; Isoxazoles; Nystagmus, Optokinetic; Picrotoxin; Receptors, GABA-A; Retina; Vision, Monocular; Visual Pathways

1992
GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1992, Volume: 27, Issue:3

    Topics: Alcohol Drinking; Animals; Baclofen; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Rats; Receptors, GABA-A

1992
Microstructural analysis of the effects of THIP, a GABAA agonist, on voluntary ethanol intake in laboratory rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:4

    Topics: Alcohol Drinking; Animals; Conditioning, Operant; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, GABA-A

1992
Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
    Journal fur Hirnforschung, 1992, Volume: 33, Issue:4-5

    Topics: Aging; Aminobutyrates; Analgesics; Animals; Baclofen; Bicuculline; Binding, Competitive; Brain; Female; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Male; Muscimol; Receptors, GABA-A; Salmon; Sexual Behavior, Animal

1992
Inhibition of tetrahydroisoxazolo-pyridin-3-ol and muscimol and its mechanism on gastrointestinal transit in mice.
    European journal of pharmacology, 1992, Sep-22, Volume: 220, Issue:2-3

    Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Isoxazoles; Male; Mice; Muscimol; Phentolamine; Propranolol; Yohimbine

1992
Plasticity of the frog monocular OKN: involvement of pretectal GABAergic and cholinergic systems.
    Neuroscience letters, 1992, Mar-30, Volume: 137, Issue:2

    Topics: Animals; Atropine; gamma-Aminobutyric Acid; Isoxazoles; Microinjections; Nystagmus, Physiologic; Parasympathetic Nervous System; Rana esculenta; Vision, Monocular

1992
Effect of a GABA agonist on the expression and distribution of GABAA receptors in the plasma membrane of cultured cerebellar granule cells: an immunocytochemical study.
    Neuroscience letters, 1991, Apr-01, Volume: 124, Issue:2

    Topics: Animals; Cell Membrane; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Rats; Receptors, GABA-A

1991
Chronic flurazepam differentially regulates a behavioral effect of GABA agonists.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:3

    Topics: Animals; Drug Interactions; Flurazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Rotation; Substantia Nigra; Time Factors

1991
Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice.
    Experimental brain research, 1991, Volume: 84, Issue:3

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Electrodes; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoxazoles; Nipecotic Acids; Potassium; Proline; Receptors, GABA-A; Temperature

1991
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
    Acta neurologica Scandinavica, 1991, Volume: 84, Issue:1

    Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Motor Activity; Nerve Degeneration; Neurons; Nipecotic Acids; Rats; Rats, Inbred Strains; Synaptic Transmission; Tiagabine

1991
GABAergic drugs and conflict behavior in the rat: lack of similarities with the actions of benzodiazepines.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:3

    Topics: Alkynes; Aminocaproates; Animals; Baclofen; Behavior, Animal; Benzodiazepines; Bicuculline; Brain; Conflict, Psychological; Drug Interactions; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1991
Effects of gamma-aminobutyric acid receptor agonists and antagonist on LHRH-synthesizing neurons as detected by immunocytochemistry and in situ hybridization.
    Experimental brain research, 1991, Volume: 87, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Female; GABA-A Receptor Antagonists; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Immunohistochemistry; Isoxazoles; Neurons; Nucleic Acid Hybridization; Ovariectomy; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; RNA Probes; RNA, Messenger

1991
Why are most GABA agonists not effective antiepileptic drugs?
    The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:2

    Topics: Animals; Anticonvulsants; Bicuculline; Cats; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Receptors, GABA-A; Synaptic Transmission; Trigeminal Nucleus, Spinal

1991
GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat.
    Pain, 1991, Volume: 47, Issue:1

    Topics: Analgesics; Anesthesia; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter

1991
Role of calcium in the analgesic action of tetrahydroisoxazolepyridinol and muscimol.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:6

    Topics: Analgesics; Animals; Calcium; Calcium Chloride; Isoxazoles; Male; Mice; Morphine; Muscimol; Nifedipine

1991
GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures.
    Psychopharmacology, 1991, Volume: 104, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Exploratory Behavior; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Social Behavior; Valproic Acid

1991
Glycinergic control of [Leu5]enkephalin levels in chicken retina.
    Brain research, 1991, Aug-23, Volume: 557, Issue:1-2

    Topics: Animals; Baclofen; Chickens; Enkephalin, Leucine; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Muscimol; Neurotransmitter Agents; Picrotoxin; Radioimmunoassay; Retina; Strychnine

1991
Activation of subconductance states by gamma-aminobutyric acid and its analogs in chick cerebral neurons.
    Pflugers Archiv : European journal of physiology, 1990, Volume: 416, Issue:4

    Topics: Analgesics; Animals; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Channels; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons

1990
Tolerance pattern to GABAmimetic analgesics and their influence on morphine tolerance and dependence.
    Fundamental & clinical pharmacology, 1991, Volume: 5, Issue:9

    Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Muscimol; Naloxone; Substance-Related Disorders

1991
Modulation of tolerance to the GABAA agonist THIP by environmental cues.
    Behavioural brain research, 1990, Jan-01, Volume: 36, Issue:1-2

    Topics: Animals; Anticonvulsants; Arousal; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxazoles; Receptors, GABA-A; Social Environment

1990
Stimulation of luteinizing hormone release by gamma-aminobutyric acid (GABA) agonists: mediation by GABAA-type receptors and activation of chloride and voltage-sensitive calcium channels.
    Endocrinology, 1990, Volume: 126, Issue:5

    Topics: Amino Acid Sequence; Animals; Baclofen; Calcium Channels; Cells, Cultured; Chloride Channels; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Isoxazoles; Luteinizing Hormone; Membrane Proteins; Molecular Sequence Data; Muscimol; Nifedipine; Pituitary Gland, Anterior; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A

1990
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells.
    Journal of neurochemistry, 1990, Volume: 55, Issue:4

    Topics: Animals; Anticonvulsants; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; Colchicine; Cycloheximide; Dactinomycin; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Monensin; Oxazoles; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, GABA-A

1990
Neurochemical correlates of gamma-aminobutyrate (GABA) inhibition in cat visual cortex.
    Life sciences, 1990, Volume: 47, Issue:15

    Topics: Animals; Baclofen; Calcium; Cats; Cell Membrane; Female; GABA Antagonists; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Neurons; Potassium; Pyridazines; Receptors, GABA-A; Visual Cortex

1990
Involvement of GABA receptors in the regulation of neurite growth in cultured embryonic chick tectum.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:4

    Topics: Animals; Axons; Baclofen; Cells, Cultured; Chick Embryo; Culture Media; gamma-Aminobutyric Acid; Isoxazoles; Ligands; Muscimol; Receptors, GABA-A; Superior Colliculi

1990
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Physical Stimulation; Somatosensory Cortex; Synapses

1990
Abolition of monocular optokinetic nystagmus directional asymmetry after unilateral visual deprivation in adult vertebrates: involvement of the GABAergic mechanism.
    Brain research. Developmental brain research, 1990, May-01, Volume: 53, Issue:2

    Topics: Animals; Chickens; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Nystagmus, Physiologic; Rana esculenta; Sensory Deprivation; Visual Pathways

1990
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
    Brain research, 1988, Jun-14, Volume: 452, Issue:1-2

    Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscimol; Phenobarbital; Receptors, GABA-A; Time Factors

1988
Binding of [3H]-muscimol to GABAA sites in the guinea-pig urinary bladder: biochemical assay and autoradiography.
    British journal of pharmacology, 1989, Volume: 96, Issue:2

    Topics: Animals; Autoradiography; Bicuculline; Binding, Competitive; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Isoxazoles; Muscimol; Receptors, GABA-A; Tritium; Urinary Bladder

1989
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
    Brain research, 1989, Sep-25, Volume: 498, Issue:1

    Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra

1989
GABAergic drugs and lordosis behavior in the female rat.
    Hormones and behavior, 1989, Volume: 23, Issue:3

    Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine

1989
Stimulation by phaclofen of inositol 1,4,5-triphosphate production in cultured neurons from chick tectum.
    European journal of pharmacology, 1989, Aug-29, Volume: 167, Issue:3

    Topics: Animals; Baclofen; Chick Embryo; gamma-Aminobutyric Acid; Inosine Nucleotides; Inosine Triphosphate; Isoxazoles; Neurons; Receptors, GABA-A; Superior Colliculi

1989
Ionic mechanisms of action of GABA on dorsal and ventral root myelinated fibers: effects of K+ channel blockers.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:10

    Topics: 4-Aminopyridine; Animals; Barium; Barium Compounds; Cesium; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Neurons; Neurons, Afferent; Potassium; Potassium Channels; Rana catesbeiana; Tetraethylammonium Compounds

1989
Late inhibitory postsynaptic potentials in rat prefrontal cortex may be mediated by GABAB receptors.
    Experientia, 1989, Feb-15, Volume: 45, Issue:2

    Topics: Animals; Baclofen; Electric Conductivity; Electric Stimulation; Evoked Potentials; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoxazoles; Male; Membrane Potentials; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Synapses

1989
Role of GABAergic system in prolactin analgesia.
    Clinical and experimental pharmacology & physiology, 1989, Volume: 16, Issue:11

    Topics: Analgesics; Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Prolactin

1989
Enzymic synthesis of two glucuronides of the hydroxyisoxazole GABA-agonist, THIP, and the in vivo glucuronidation of THIP in rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:12

    Topics: Animals; Chromatography, High Pressure Liquid; Glucuronates; Glucuronidase; Hydrolysis; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxazoles; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet

1989
Baclofen-induced, calcium-dependent stimulation of in vivo release of D-[3H]aspartate from rat hippocampus monitored by intracerebral microdialysis.
    Neurochemical research, 1989, Volume: 14, Issue:4

    Topics: Animals; Aspartic Acid; Baclofen; Calcium; GABA Antagonists; Hippocampus; Ischemic Attack, Transient; Isoxazoles; Male; Potassium; Rats; Rats, Inbred Strains

1989
Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:6

    Topics: Anesthetics; Animals; Axons; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Myelin Sheath; Oxazoles; Potassium; Rana catesbeiana; Spinal Cord

1989
GABA-benzodiazepine modulation of aversion in the medial hypothalamus of the rat.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:1

    Topics: Animals; Avoidance Learning; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Flumazenil; Hypothalamus, Middle; Isoxazoles; Male; Microinjections; Midazolam; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Adrenal Medulla; Analgesics; Animals; Bicuculline; Catecholamines; Dogs; Electric Stimulation; Enkephalins; Female; Isoxazoles; Oxazoles; Receptors, GABA-A; Splanchnic Nerves

1987
Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.
    Neuroscience letters, 1987, Nov-10, Volume: 82, Issue:1

    Topics: Action Potentials; Adenylate Cyclase Toxin; Animals; Baclofen; Hippocampus; In Vitro Techniques; Isoxazoles; Neural Conduction; Neural Inhibition; Pertussis Toxin; Rats; Receptors, GABA-A; Virulence Factors, Bordetella

1987
Structural factors governing agonist and antagonist activity in the GABAA system.
    Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5

    Topics: Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Receptors, GABA-A; Structure-Activity Relationship

1988
3- and 5-isoxazolol zwitterions: an ab initio molecular orbital study relating to GABA agonism and antagonism.
    Journal of theoretical biology, 1987, Aug-21, Volume: 127, Issue:4

    Topics: Chemical Phenomena; Chemistry; Crotonates; GABA Antagonists; Isoxazoles; Molecular Conformation; Muscimol; Pyridines; Receptors, GABA-A

1987
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus.
    Neuroscience letters, 1988, May-03, Volume: 87, Issue:3

    Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus

1988
GABA-related drugs modulate the behavioral effects of lorazepam.
    Psychopharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Behavior, Animal; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Lorazepam; Male; Oxazoles; Receptors, GABA-A; Saimiri

1988
Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1987, Volume: 5, Issue:3

    Topics: Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors

1987
GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1988, Volume: 6, Issue:2

    Topics: Animals; Cells, Cultured; Cerebellar Cortex; Isoxazoles; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1988
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine

1988
Inhibition of sexual reflexes by lumbosacral injection of a GABAB agonist in the male rat.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:3

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Spinal; Isoxazoles; Lumbosacral Region; Male; Penile Erection; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Spinal Cord

1988
The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs.
    Neuropharmacology, 1985, Volume: 24, Issue:4

    Topics: Acetylcholine; Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Ethanolamines; Female; gamma-Aminobutyric Acid; Guinea Pigs; Isoxazoles; Male; Muscimol; Serotonin Antagonists

1985
Quantitative electrocortical changes in the rat induced by phencyclidine and other stimulants.
    Neuropharmacology, 1985, Volume: 24, Issue:4

    Topics: Animals; Apomorphine; Baclofen; Cerebral Cortex; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Dioxolanes; Electroencephalography; Isoquinolines; Isoxazoles; Male; Muscimol; Phencyclidine; Rats; Rats, Inbred Strains

1985
Excitatory amino acids: studies on the biochemical and chemical stability of ibotenic acid and related compounds.
    Journal of neurochemistry, 1985, Volume: 45, Issue:3

    Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Decarboxylation; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Ibotenic Acid; Isoxazoles; Liver; Mice; Muscimol; Oxazoles; Pregnancy Proteins

1985
Discriminative stimulus effects of atypical anxiolytics in baboons and rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepinones; Buspirone; Discrimination Learning; Flumazenil; Isoxazoles; Lorazepam; Male; Papio; Piperazines; Pyrazoles; Pyridazines; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
Intrinsic gamma aminobutyric acid receptors modulate the release of catecholamine from canine adrenal gland in situ.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2

    Topics: Adrenal Medulla; Animals; Baclofen; Bicuculline; Chromaffin Granules; Dogs; Electric Stimulation; Epinephrine; Female; Hexamethonium; Hexamethonium Compounds; Histocytochemistry; Isoxazoles; Muscimol; Naloxone; Norepinephrine; Receptors, GABA-A; Splanchnic Nerves

1986
Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.
    The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:12

    Topics: Analgesics; Animals; Baclofen; Desipramine; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias.
    Psychopharmacology, 1988, Volume: 94, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Antipsychotic Agents; Cebus; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Vigabatrin

1988
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
    Experimental neurology, 1989, Volume: 104, Issue:1

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures

1989
Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex.
    Life sciences, 1985, Feb-04, Volume: 36, Issue:5

    Topics: Acetylcholine; Animals; Atropine; Baclofen; Benzodiazepinones; Clonazepam; Corpus Striatum; Electric Stimulation; Flumazenil; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A

1985
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
    Journal of neurochemistry, 1985, Volume: 44, Issue:4

    Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine

1985
Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Blood Pressure; Carbolines; Clonidine; Cyproheptadine; Diazepam; Epinephrine; Heart Rate; Humans; Hydrocortisone; Indoles; Isoxazoles; Macaca mulatta; Male; Norepinephrine; Propranolol

1985
Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.
    Life sciences, 1985, Feb-25, Volume: 36, Issue:8

    Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Synergism; Electroshock; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Nervous System; Receptors, GABA-A

1985
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
    Neuropharmacology, 1985, Volume: 24, Issue:3

    Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Oxazoles; Postural Balance; Receptors, GABA-A

1985
Parallel changes in the sensitivity of gamma-aminobutyric acid and noradrenergic receptors following chronic administration of antidepressant and GABAergic drugs. A possible role in affective disorders.
    Neuropharmacology, 1985, Volume: 24, Issue:3

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Baclofen; Cerebral Cortex; Dihydroalprenolol; gamma-Aminobutyric Acid; Hippocampus; Humans; Imipramine; Isoxazoles; Kinetics; Male; Mice; Mood Disorders; Nomifensine; Receptors, Adrenergic; Receptors, GABA-A

1985
GABAergic drugs and sexual behaviour in the male rat.
    European journal of pharmacology, 1985, Jun-19, Volume: 112, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal

1985
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
    Experimental neurology, 1985, Volume: 89, Issue:2

    Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, Neurologic; Muscimol; Muscle Relaxation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures

1985
Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analogue of the GABA agonist THIP.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:8

    Topics: Animals; Anticonvulsants; Cerebellum; Electrophysiology; Female; Isoxazoles; Male; Mice; Muscimol; Oxazoles; Rats; Receptors, GABA-A

1985
Diazepam antagonizes GABAmimetics in rats with spontaneous petit mal-like epilepsy.
    European journal of pharmacology, 1985, Jul-11, Volume: 113, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Cycloserine; Diazepam; Epilepsy, Absence; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vigabatrin

1985
GABAergic effects of reserpine following chronic treatment.
    Psychopharmacology, 1985, Volume: 87, Issue:2

    Topics: Animals; Baclofen; Binding, Competitive; Cerebral Cortex; Dihydroalprenolol; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Isoxazoles; Male; Mice; Receptors, GABA-A; Reserpine

1985
The locomotor-reducing effects of GABAergic drugs do not depend on the GABAA receptor.
    Psychopharmacology, 1985, Volume: 87, Issue:1

    Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taurine

1985
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Animals; Bicuculline; Brain; Cats; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Oxazolidinones; Piperidines; Rats; Receptors, GABA-A; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes

1985
GABAergic involvement in the antinociceptive effects of morphine at the level of the periaqueductal gray matter in the rat.
    Proceedings of the Western Pharmacology Society, 1985, Volume: 28

    Topics: Animals; Isoxazoles; Male; Morphine; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, GABA-A

1985
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.
    Physiology & behavior, 1985, Volume: 35, Issue:3

    Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1985
Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray.
    European journal of pharmacology, 1985, Nov-05, Volume: 117, Issue:2

    Topics: Animals; Behavior, Animal; Bicuculline; Escape Reaction; Hypothalamus, Middle; Isoxazoles; Male; Mesencephalon; Microinjections; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Superior Colliculi

1985
Autoradiographic localization of binding sites for the gamma-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord.
    Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2

    Topics: Animals; Animals, Newborn; Autoradiography; Baclofen; Binding Sites; Cells, Cultured; Cerebellum; Fetus; Isonicotinic Acids; Isoxazoles; Oxazoles; Rats; Receptors, GABA-A; Spinal Cord

1985
GABAB receptor-mediated enhancement of vasoactive intestinal peptide-stimulated cyclic AMP production in slices of rat cerebral cortex.
    Journal of neurochemistry, 1986, Volume: 46, Issue:6

    Topics: Amino Acids; Amino Acids, Neutral; Animals; Baclofen; Bicuculline; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasoactive Intestinal Peptide

1986
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures

1986
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Receptors, GABA-A; Seizures

1986
gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.
    Molecular pharmacology, 1986, Volume: 29, Issue:5

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Baclofen; Bicuculline; Brain; Cell Membrane; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Liver; Male; Mice; Mice, Inbred DBA; Muscimol; Picrotoxin; Receptors, GABA-A; Sodium; Sulfates; Taurine; Temperature

1986
Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:3

    Topics: Aggression; Aminocaproates; Animals; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Motor Activity; Muscimol; Nipecotic Acids; Olfactory Bulb; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission; Valproic Acid; Vigabatrin

1986
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors.
    Neurochemical research, 1986, Volume: 11, Issue:4

    Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Intracellular Membranes; Isoxazoles; Kinetics; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
Glycine antagonists structurally related to 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol inhibit binding of [3H]strychnine to rat brain membranes.
    Journal of neurochemistry, 1986, Volume: 47, Issue:3

    Topics: Animals; Anions; Binding, Competitive; Cell Membrane; Chlorides; Choline; GABA Antagonists; Glycine; Isoxazoles; Male; Medulla Oblongata; Oxazoles; Pons; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Sodium Chloride; Strychnine

1986
The parafasciculus thalami as a site for mediating the antinociceptive response to GABAergic drugs.
    Brain research, 1986, Sep-24, Volume: 383, Issue:1-2

    Topics: Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Synaptic Transmission; Thalamic Nuclei

1986
[Changes in the ligand affinity of benzodiazepine receptors in the presence of 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP)].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:2

    Topics: Animals; Brain; Depression, Chemical; Dose-Response Relationship, Drug; Flunitrazepam; In Vitro Techniques; Isoxazoles; Ligands; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat.
    Life sciences, 1987, Mar-02, Volume: 40, Issue:9

    Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA.
    European journal of pharmacology, 1987, Mar-17, Volume: 135, Issue:2

    Topics: Animals; Avoidance Learning; Baclofen; Electrodes, Implanted; gamma-Aminobutyric Acid; Isoxazoles; Male; Mesencephalon; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
Hypnotic action of pentobarbital in mice: a possible mechanism.
    Experimental neurology, 1987, Volume: 97, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Isoxazoles; Male; Mice; Oxazoles; Pentobarbital; Receptors, GABA-A; Reflex; Sleep

1987
Effects of GABAergic drugs on the GABA turnover in the substantia nigra and the corpus striatum of the rat.
    Journal of neural transmission, 1987, Volume: 69, Issue:1-2

    Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Corpus Striatum; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra

1987
[Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:6

    Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrazoles; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Tranquilizing Agents

1987
Cardiorespiratory effects produced by injecting drugs that affect GABA receptors into nuclei associated with the ventral surface of the medulla.
    Neuropharmacology, 1987, Volume: 26, Issue:5

    Topics: Animals; Bicuculline; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Muscimol; Respiration; Synaptic Transmission

1987
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
    Neuropharmacology, 1987, Volume: 26, Issue:5

    Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission

1987
Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 62, Issue:6

    Topics: Animals; Baclofen; Bicuculline; Cats; Female; Heart; Injections, Intravenous; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, GABA-A; Respiration

1987
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4

    Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid

1986
Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1988, Volume: 8, Issue:12

    Topics: Adenylate Cyclase Toxin; Animals; Baclofen; Brain; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neural Inhibition; Neurons; Pertussis Toxin; Rats; Synapses; Thionucleotides; Time Factors; Virulence Factors, Bordetella

1988
Inducing anesthesia with a GABA analog, THIP.
    Anesthesiology, 1985, Volume: 63, Issue:2

    Topics: Analgesics; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; gamma-Aminobutyric Acid; Isoxazoles; Ketamine; Male; Mice; Midazolam; Oxazoles; Rats; Rats, Inbred Strains; Sodium Oxybate; Time Factors

1985
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1

    Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Body Temperature; Desipramine; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains

1988
The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Behavior; Carotid Arteries; Cerebrovascular Circulation; Dominance, Cerebral; Electroencephalography; gamma-Aminobutyric Acid; Humans; Injections, Intra-Arterial; Isoxazoles; Middle Aged; Neural Inhibition; Oxazoles; Synapses

1988
Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development.
    Journal of neurochemistry, 1988, Volume: 51, Issue:1

    Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasm; Endoplasmic Reticulum; gamma-Aminobutyric Acid; Golgi Apparatus; Isoxazoles; Microscopy, Electron; Oxazoles; Rats; Rats, Inbred Strains

1988
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
    Brain research, 1988, May-31, Volume: 450, Issue:1-2

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds

1988
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat.
    Brain research, 1987, Dec-15, Volume: 436, Issue:2

    Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Periaqueductal Gray; Picrotoxin; Raphe Nuclei; Rats; Rats, Inbred Strains

1987
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
    Neuropharmacology, 1987, Volume: 26, Issue:4

    Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Motor Activity; Pain; Pyrans; Pyrones

1987
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
    Neuropharmacology, 1987, Volume: 26, Issue:7A

    Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium

1987
Intrathecal administration of pentobarbital and THIP: evidence for descending excitatory and inhibitory modulation of a spinal reflex.
    Proceedings of the Western Pharmacology Society, 1987, Volume: 30

    Topics: Analgesics; Animals; Efferent Pathways; Injections, Spinal; Isoxazoles; Male; Neural Inhibition; Oxazoles; Pentobarbital; Rats; Rats, Inbred Strains; Reflex; Spinal Cord

1987
Effect of repeated treatment with a gamma-aminobutyric acid receptor agonist on postnatal neural development in rats.
    Journal of neurochemistry, 1987, Volume: 49, Issue:5

    Topics: Animals; Antigens, Surface; Brain; Cell Adhesion; Cell Adhesion Molecules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Isoxazoles; Nerve Tissue Proteins; Neurons; Organ Size; Oxazoles; Rats; Rats, Inbred Strains

1987
Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Baclofen; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Histamine; Isoxazoles; Male; Methylhistamines; Methylhistidines; Mice; Muscimol

1986
The effect of diazepam upon local cerebral glucose use in the conscious rat.
    Neuroscience, 1986, Volume: 19, Issue:1

    Topics: Animals; Autoradiography; Brain Chemistry; Deoxy Sugars; Deoxyglucose; Diazepam; Energy Metabolism; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains

1986
GABA-mimetic drugs enhance apomorphine-induced contralateral turning in rats with unilateral nigrostriatal dopamine denervation: implications for the therapy of Parkinson's disease.
    Annals of neurology, 1987, Volume: 21, Issue:1

    Topics: Alkynes; Aminocaproates; Animals; Antiparkinson Agents; Apomorphine; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Parkinson Disease; Rats; Rats, Inbred Strains

1987
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
    Brain research, 1985, Jul-15, Volume: 338, Issue:2

    Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine

1985
Blockade of "antiabsence" activity of sodium valproate by THIP in rats with petit mal-like seizures. Comparison with ethosuximide.
    Journal of neural transmission, 1985, Volume: 63, Issue:2

    Topics: Animals; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Injections; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Valproic Acid

1985
Subchronic administration of GABAergic agonists elevates [3H]GABA binding and produces tolerance in striatal dopamine catabolism.
    Brain research, 1985, May-27, Volume: 335, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Isoxazoles; Male; Pyrones; Rats; Rats, Inbred Strains; Vigabatrin

1985
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 276, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity

1985
Shock titration in the rhesus monkey: effects of opiate and nonopiate analgesics.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Administration, Oral; Analgesics; Animals; Aspirin; Codeine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Ibuprofen; Injections, Intramuscular; Isoxazoles; Male; Morphine; Narcotics; Reaction Time; Sensory Thresholds; Time Factors

1985
GABAergic mechanisms in antinociception.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin

1984
Somatic and dendritic actions of gamma-aminobutyric acid agonists and uptake blockers in the hippocampus in vivo.
    Neuroscience, 1984, Volume: 12, Issue:2

    Topics: Acetylcholine; Action Potentials; Animals; Dendrites; gamma-Aminobutyric Acid; Hippocampus; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Synaptic Transmission

1984
GABAergic agents as anticonvulsants in baboons with photosensitive epilepsy.
    Neuroscience letters, 1984, Jun-29, Volume: 47, Issue:3

    Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Carbolines; Cerebral Cortex; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Papio; Photic Stimulation; Receptors, Cell Surface; Receptors, GABA-A; Taurine; Vigabatrin

1984
Pretreatment with GABA and modulatory ligands enhances GABA receptor binding.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Animals; Baclofen; Binding Sites; Cerebral Cortex; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes

1984
Involvement of central GABAergic receptors in the control over offensive and defensive behaviours in the rat.
    Progress in clinical and biological research, 1984, Volume: 167

    Topics: Aggression; Animals; Bicuculline; Electroshock; Humans; Injections, Intraventricular; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A

1984
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds

1984
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.
    Neuropharmacology, 1984, Volume: 23, Issue:12A

    Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A

1984
Differential reversal by scopolamine and THIP of the antistereotypic and cataleptic effects of neuroleptics.
    European journal of pharmacology, 1981, Jan-05, Volume: 69, Issue:1

    Topics: Amphetamine; Animals; Antipsychotic Agents; Catalepsy; Humans; Isoxazoles; Male; Oxazoles; Rats; Scopolamine; Stereotyped Behavior

1981
Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum.
    European journal of pharmacology, 1981, Mar-12, Volume: 70, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Bicuculline; Binding Sites; Cerebellum; Chlorides; Etazolate; Flunitrazepam; Isoxazoles; Male; Muscimol; Nicotinic Acids; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium

1981
Stimulated release of 3H-glycine from retina.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1982, Volume: 218, Issue:1

    Topics: Animals; Aporphines; Aspartic Acid; Cysteic Acid; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Muscimol; Rabbits; Retina

1982
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:10

    Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Time Factors

1982
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
    Neuroscience letters, 1980, Oct-02, Volume: 19, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium

1980
Cardiovascular effects of THIP in the rat.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:11

    Topics: Animals; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Rats, Inbred Strains

1983
GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells.
    Journal of neurochemistry, 1984, Volume: 43, Issue:6

    Topics: Animals; Calcium; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoxazoles; Muscimol; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A

1984
Therapeutic failure of GABA agonist treatment in Huntington's disease.
    Neurology, 1984, Volume: 34, Issue:5

    Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles

1984
Multiple benzodiazepine receptor complexes: some benzodiazepine recognition sites are coupled to GABA receptors and ionophores.
    Advances in biochemical psychopharmacology, 1980, Volume: 21

    Topics: Animals; Anions; Benzodiazepines; Bicuculline; Brain; Buffers; Flunitrazepam; gamma-Aminobutyric Acid; Haplorhini; Hot Temperature; Ionophores; Isonicotinic Acids; Isoxazoles; Macromolecular Substances; Papio; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter

1980
Heterogeneous depression of glucose utilization in the caudate nucleus by GABA agonists.
    Brain research, 1981, Mar-30, Volume: 209, Issue:2

    Topics: Animals; Autoradiography; Blood Glucose; Caudate Nucleus; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A

1981
Role of GABA-ergic receptors for the synthesis of GABA in different compartments of the rat cerebellum.
    Acta physiologica Scandinavica, 1981, Volume: 112, Issue:1

    Topics: Aminooxyacetic Acid; Animals; Bicuculline; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, Cell Surface; Receptors, GABA-A

1981
The binding of the GABA agonist [3H]THIP to rat brain synaptic membranes.
    Journal of neurochemistry, 1982, Volume: 38, Issue:4

    Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Tritium

1982
Orally administered THIP inhibits food intake in the rat.
    Behavioral and neural biology, 1982, Volume: 34, Issue:1

    Topics: Administration, Oral; Animals; Bicuculline; Dose-Response Relationship, Drug; Eating; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1982
THIP inhibits feeding behavior in fasted rats.
    Psychopharmacology, 1982, Volume: 76, Issue:1

    Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Eating; Food Deprivation; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1982
Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Corpus Striatum; Diazepam; Dopamine; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Neural Pathways; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Substantia Nigra

1982
Central cardiovascular effects produced by the GABA receptor agonist drug, THIP.
    Neuropharmacology, 1982, Volume: 21, Issue:6

    Topics: Animals; Autonomic Nervous System; Bicuculline; Blood Pressure; Brain; Cats; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A

1982
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
    Journal of neurochemistry, 1982, Volume: 39, Issue:5

    Topics: Animals; Cats; gamma-Aminobutyric Acid; Glycine; Interneurons; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Structure-Activity Relationship

1982
Autoreceptors modify the evoked release of [3H]GABA from cerebellar neurons in dissociated cell culture.
    European journal of pharmacology, 1982, Aug-27, Volume: 82, Issue:3-4

    Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Fluspirilene; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Neurons; Potassium; Rats; Receptors, Cell Surface; Receptors, GABA-A

1982
GABAergic modulation of ethanol-induced motor impairment.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminobutyrates; Aminocaproates; Animals; Bicuculline; Brain; Ethanol; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Skills; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1982
gamma-aminobutyric acid receptors modulate cation binding sites coupled to independent benzodiazepine, picrotoxin, and anion binding sites.
    Molecular pharmacology, 1982, Volume: 22, Issue:2

    Topics: Animals; Binding Sites; Brain; Calcium Chloride; Electrolytes; Flunitrazepam; In Vitro Techniques; Isoxazoles; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Sodium Chloride

1982
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
    Physiology & behavior, 1982, Volume: 29, Issue:5

    Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine

1982
The acute effect of the GABA-agonist, THIP, on proprioceptive and flexor reflexes in spastic patients.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:1

    Topics: Adult; Female; Humans; Isoxazoles; Male; Mechanoreceptors; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Oxazoles; Paraplegia; Proprioception; Reaction Time; Receptors, Cell Surface; Receptors, GABA-A; Reflex, Monosynaptic; Reflex, Stretch

1983
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:6

    Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes

1983
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disease Susceptibility; Ethanol; Forelimb; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Tremor

1983
GABA as a trophic factor during development.
    Life sciences, 1983, Sep-05, Volume: 33, Issue:10

    Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Nipecotic Acids; Proline; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Retina

1983
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes.
    Neuroscience letters, 1983, Aug-08, Volume: 38, Issue:3

    Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1983
Comparison of GABA analogues at the crayfish stretch receptor neurone.
    Brain research bulletin, 1983, Volume: 11, Issue:3

    Topics: Animals; Astacoidea; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Isoxazoles; Mechanoreceptors; Membrane Potentials; Muscimol; Nipecotic Acids; Proline; Sodium

1983
Benzodiazepine receptor mediated discriminative cues: effects of GABA-ergic drugs and inverse agonists.
    Life sciences, 1983, Nov-28, Volume: 33, Issue:22

    Topics: Animals; Cues; Diazepam; Discrimination Learning; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1983
Antinociceptive effect of the GABAmimetic 4,5,6,7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP): chronic treatment increases alpha-2 adrenoceptors in the mouse brain.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:2

    Topics: Analgesics; Animals; Brain Chemistry; Clonidine; Drug Tolerance; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, GABA-A

1984
Diazotization and thiocyanate differentiate agonists from antagonists for the high- and low-affinity receptors of gamma-aminobutyric acid.
    Journal of neurochemistry, 1984, Volume: 43, Issue:1

    Topics: Androstanes; Animals; Azasteroids; Benzenesulfonates; Bicuculline; Cerebral Cortex; Diazonium Compounds; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids; Thiocyanates; Tubocurarine

1984
Pharmacological analysis of the central cardiovascular effects of four GABA analogues.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 325, Issue:4

    Topics: Animals; Atropine; Bicuculline; Blood Pressure; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Isonicotinic Acids; Isoxazoles; Kainic Acid; Muscimol; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1984
Microiontophoretically applied THIP effects upon nociceptive responses of neurons in medial thalamus.
    Applied neurophysiology, 1983, Volume: 46, Issue:5-6

    Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinothalamic Tracts; Synaptic Transmission; Tail; Thalamic Nuclei

1983
Effect of apomorphine and gabaergic drugs in monkeys pretreated with haloperidol.
    Psychopharmacology, 1983, Volume: 79, Issue:2-3

    Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Apomorphine; Chlorocebus aethiops; Female; gamma-Aminobutyric Acid; Haloperidol; Hemodynamics; Isoxazoles; Male; Motor Activity; Muscimol; Picrotoxin

1983
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid

1983
Effects of THIP on chronic anxiety.
    Psychopharmacology, 1983, Volume: 80, Issue:4

    Topics: Adult; Anxiety Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Psychiatric Status Rating Scales

1983
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia.
    Psychopharmacology, 1984, Volume: 82, Issue:1-2

    Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced

1984
Gabaergic modulation of mouse-killing in the rat.
    Psychopharmacology, 1984, Volume: 83, Issue:4

    Topics: Aggression; Aminocaproates; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nipecotic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid; Vigabatrin

1984
Flight induced by infusion of bicuculline methiodide into periventricular structures.
    Brain research, 1984, Sep-10, Volume: 309, Issue:2

    Topics: Animals; Bicuculline; Brain Mapping; Escape Reaction; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus, Middle; Isoxazoles; Male; Motor Activity; Periaqueductal Gray; Rats; Rats, Inbred Strains

1984
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
    Neuropharmacology, 1984, Volume: 23, Issue:9

    Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Penicillins; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Taurine; Time Factors

1984
Self-injurious behavior in rats produced by intranigral microinjection of GABA agonists.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Inbred Strains; Self Mutilation; Stress, Physiological; Substantia Nigra

1984
Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold.
    European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2

    Topics: Animals; Baclofen; Injections, Spinal; Isoxazoles; Male; Muscimol; Muscle Hypotonia; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds

1984
The influence of GABAergic drugs on PGO activity in the cat.
    Neuropharmacology, 1983, Volume: 22, Issue:7

    Topics: Alkynes; Aminocaproates; Animals; Brain; Cats; Chlordiazepoxide; Electroencephalography; Female; gamma-Aminobutyric Acid; Geniculate Bodies; Isoxazoles; Male; Muscimol; Occipital Lobe; Pons

1983
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Analgesics; Animals; Baclofen; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Motor Activity; Muscimol; Oxazoles; Physical Stimulation; Rats; Rats, Inbred Strains; Superior Colliculi; Touch

1983
Anorexic and analgesic actions of THIP.
    Advances in biochemical psychopharmacology, 1983, Volume: 37

    Topics: Analgesics; Animals; Appetite Depressants; Behavior, Animal; Benzoquinones; Drug Interactions; Feeding Behavior; Isoxazoles; Male; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time

1983
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:5

    Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain

1983
Pharmacokinetics of the gamma-aminobutyric acid agonist THIP (Gaboxadol) following intramuscular administration to man, with observations in dog.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:5

    Topics: Absorption; Adult; Animals; Dogs; Humans; Injections, Intramuscular; Isoxazoles; Kinetics; Male; Models, Biological; Oxazoles

1983
Comparison of the analgesic actions of THIP and morphine.
    General pharmacology, 1983, Volume: 14, Issue:6

    Topics: Analgesics; Animals; Atropine; Benzoquinones; Bicuculline; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Morphine; Naloxone; Oxazoles; Quinones; Reaction Time

1983
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist.
    Physiology & behavior, 1983, Volume: 30, Issue:3

    Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time

1983
State of DA/ACh balance after chronic treatment with haloperidol and with THIP in rats.
    Advances in neurology, 1984, Volume: 40

    Topics: Acetylcholine; Animals; Apomorphine; Atropine; Behavior, Animal; Brain; Dopamine; Haloperidol; Isoxazoles; Male; Oxazoles; Physostigmine; Rats; Rats, Inbred Strains

1984
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neurons; Rabbits; Synapses

1984
Diazepam enhances the action but not the binding of the GABA analog, THIP.
    Brain research, 1984, Apr-09, Volume: 297, Issue:1

    Topics: Animals; Brain; Chlorides; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Spinal; Isoxazoles; Membrane Potentials; Mice; Oxazoles; Rats; Spinal Cord

1984
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
    European journal of pharmacology, 1980, Feb-08, Volume: 61, Issue:3

    Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors

1980
Nigral actions of GABA agonists are enhanced by chronic fluphenazine and differentiated by concomitant flurazepam.
    Psychopharmacology, 1982, Volume: 76, Issue:3

    Topics: Animals; Baclofen; Bicuculline; Female; Fluphenazine; Flurazepam; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra

1982
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1

    Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds

1983
THIP analgesia: cross tolerance with morphine.
    Life sciences, 1983, May-09, Volume: 32, Issue:19

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Models, Biological; Morphine; Nipecotic Acids; Oxazoles; Pyrones

1983
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212).
    European journal of pharmacology, 1983, Jun-03, Volume: 90, Issue:2-3

    Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors

1983
Quantitative determination of the gamma-aminobutyric acid agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, in serum by high-performance liquid chromatography.
    Journal of chromatography, 1983, May-13, Volume: 274

    Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Oxazoles; Papio; Rats; Spectrophotometry, Ultraviolet

1983
Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation.
    Journal of neurochemistry, 1982, Volume: 39, Issue:3

    Topics: Analgesics; Animals; Brain; Deoxy Sugars; Deoxyglucose; gamma-Aminobutyric Acid; Glycolysis; Isoxazoles; Male; Muscimol; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains

1982
Effects of GABA analogues and their interactions with morphine on locomotor activity in two inbred strains of mice.
    Pharmacological research communications, 1982, Volume: 14, Issue:5

    Topics: Animals; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Muscimol; Piracetam

1982
Differentiation of the analgesic effects of THIP and morphine using three mouse strains.
    Drug and alcohol dependence, 1982, Volume: 9, Issue:3

    Topics: Analgesics; Animals; GABA Antagonists; Hot Temperature; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles

1982
Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro.
    The Journal of physiology, 1982, Volume: 328

    Topics: Animals; Bicuculline; Dendrites; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Penicillins; Pentobarbital; Pyramidal Tracts; Rats; Receptors, Drug

1982
Comparison of the antinociceptive actions of THIP and morphine.
    Pharmacological research communications, 1982, Volume: 14, Issue:10

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Reaction Time; Species Specificity

1982
Antinociceptive and anticonvulsive effect of THIP, a pure GABA agonist.
    Polish journal of pharmacology and pharmacy, 1982, Volume: 34, Issue:1-3

    Topics: Analgesics; Animals; Anticonvulsants; Benzoquinones; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time

1982
Analgesic properties of the GABA-mimetic THIP.
    European journal of pharmacology, 1981, Jan-16, Volume: 69, Issue:2

    Topics: Analgesics; Animals; Arthritis, Experimental; Baclofen; Electric Stimulation; Isoxazoles; Macaca mulatta; Mice; Morphine; Muscimol; Oxazoles; Reaction Time

1981
Increases and decreases in local cerebral glucose utilization in response to GABA agonists.
    European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3

    Topics: Animals; Brain; gamma-Aminobutyric Acid; Glucose; Isoxazoles; Male; Muscimol; Oxazoles; Rats

1981
GABA in the entopeduncular nucleus and the subthalamic nucleus participates in mediating dopaminergic striatal output functions.
    Life sciences, 1981, Oct-12, Volume: 29, Issue:15

    Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Mesencephalon; Muscimol; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Thalamic Nuclei

1981
Etomidate stereospecifically stimulates forebrain, but not cerebellar, 3H-diazepam binding.
    Life sciences, 1981, Dec-21, Volume: 29, Issue:25

    Topics: Animals; Brain; Cerebellum; Diazepam; Etomidate; Female; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereoisomerism; Synaptic Membranes

1981
Paradoxical blockade of a muscimol response by THIP, a GABA agonist and also by GABA-transaminase inhibitors.
    Neuropharmacology, 1981, Volume: 20, Issue:12A

    Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Myoclonus; Oxazoles; Time Factors; Transaminases

1981
Preliminary studies on the absorption, distribution, metabolism, and excretion of THIP in animal and man using 14C-labelled compound.
    Acta pharmacologica et toxicologica, 1981, Volume: 49, Issue:2

    Topics: Absorption; Adult; Animals; Brain; Carbon Radioisotopes; Chromatography, Thin Layer; Half-Life; Humans; Hydrolysis; Isoxazoles; Male; Mice; Mice, Inbred Strains; Middle Aged; Oxazoles; Rats; Rats, Inbred Strains; Tissue Distribution

1981
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Motor Activity; Muscimol; Pain; Phencyclidine; Reflex

1980
GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA.
    European journal of pharmacology, 1980, Jul-11, Volume: 65, Issue:1

    Topics: Animals; Binding Sites; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Oxazoles; Rats; Substantia Nigra

1980
Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons.
    European journal of pharmacology, 1980, Aug-22, Volume: 66, Issue:1

    Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Injections, Intravenous; Isoxazoles; Limbic System; Muscimol; Neurons; Rats

1980
Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.
    Molecular pharmacology, 1995, Volume: 48, Issue:4

    Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Benzodiazepines; Binding Sites; Binding, Competitive; Blotting, Western; Cattle; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Macromolecular Substances; Molecular Sequence Data; Muscimol; Precipitin Tests; Rabbits; Rats; Receptors, GABA-A; Sensitivity and Specificity; Sequence Homology, Amino Acid; Tritium

1995
Differential distribution of GABAA receptor subunits in soma and processes of cerebellar granule cells: effects of maturation and a GABA agonist.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, Volume: 13, Issue:5

    Topics: Animals; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; GABA Agonists; GABA-A Receptor Agonists; Immunohistochemistry; Isoxazoles; Microscopy, Immunoelectron; Neurons; Rats; Rats, Wistar; Receptors, GABA-A

1995
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
    Epilepsia, 1995, Volume: 36, Issue:10

    Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra

1995
Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.
    Journal of medicinal chemistry, 1995, Aug-18, Volume: 38, Issue:17

    Topics: Animals; Cells, Cultured; Cerebral Cortex; GABA-A Receptor Agonists; Isoxazoles; Magnetic Resonance Spectroscopy; Mice; Neurons; Rats; Rats, Sprague-Dawley

1995
omega-Conotoxin binding sites and regulation of transmitter release in cerebellar granule neurons.
    Journal of neuroscience research, 1994, Nov-01, Volume: 39, Issue:4

    Topics: Animals; Aspartic Acid; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cations, Divalent; Cell Membrane; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GABA Agonists; Hot Temperature; Isoxazoles; Kinetics; Neurons; omega-Conotoxins; Peptides; Potassium Chloride; Prosencephalon; Rats

1994
Role of GABAB receptors in intracellular Ca2+ homeostasis and possible interaction between GABAA and GABAB receptors in regulation of transmitter release in cerebellar granule neurons.
    Journal of neuroscience research, 1994, Dec-15, Volume: 39, Issue:6

    Topics: Animals; Aspartic Acid; Baclofen; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; GABA Agonists; GTP-Binding Proteins; Homeostasis; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Neurotransmitter Agents; Pertussis Toxin; Receptors, GABA-A; Receptors, GABA-B; Virulence Factors, Bordetella

1994
Induction of low-affinity GABAA receptors by the GABA-agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in cultured rat cerebellar granule cells is prevented by inhibition of polyamine biosynthesis.
    Journal of neuroscience research, 1994, Dec-15, Volume: 39, Issue:6

    Topics: Animals; Biogenic Polyamines; Cells, Cultured; Cerebellum; Eflornithine; GABA Agonists; Isoxazoles; Kinetics; Membranes; Neurons; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, GABA-A; Spermidine

1994
Extrasynaptic effects of GABA (gamma-aminobutyric acid) agonists on myelinated axons of peripheral nerve.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:4

    Topics: Action Potentials; Animals; Axons; Baclofen; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Nerve Fibers, Myelinated; Peripheral Nerves; Rana catesbeiana; Ranidae; Sciatic Nerve; Spinal Nerve Roots; Synapses

1994
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.
    Molecular pharmacology, 1994, Volume: 46, Issue:5

    Topics: Animals; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Oocytes; Oxazolidinones; Piperidines; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus

1994
Stimulation or blockade of the dorsal nucleus of the lateral lemniscus alters binaural and tonic inhibition in contralateral inferior colliculus neurons.
    Hearing research, 1993, Volume: 69, Issue:1-2

    Topics: Acoustic Stimulation; Animals; Auditory Pathways; Electric Stimulation; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Lidocaine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA; Spiral Ganglion

1993
GABA alters GABAA receptor mRNAs and increases ligand binding.
    Journal of neurochemistry, 1993, Volume: 61, Issue:6

    Topics: Animals; Anticonvulsants; Base Sequence; Bicuculline; Cells, Cultured; Cerebellum; DNA Primers; gamma-Aminobutyric Acid; Gene Expression; Isoxazoles; Macromolecular Substances; Molecular Sequence Data; Muscimol; Neurons; Polymerase Chain Reaction; Rats; Receptors, GABA-A; RNA, Messenger

1993
Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:1

    Topics: Alcohol Drinking; Animals; Appetite Depressants; Body Weight; Chloride Channels; GABA-A Receptor Antagonists; Isoxazoles; Male; Picrotoxin; Rats; Receptors, GABA-A; Self Administration

1993
Conformational analysis and molecular modelling of a partial GABAA agonist and a glycine antagonist related to the GABAA agonist, THIP.
    Drug design and discovery, 1993, Volume: 10, Issue:3

    Topics: Analgesics; Glycine; Isoxazoles; Models, Molecular; Molecular Conformation; Receptors, GABA; Stereoisomerism; Structure-Activity Relationship

1993
gamma-Aminobutyric acid-A (GABAA) agonists down-regulate GABAA/benzodiazepine receptor polypeptides from the surface of chick cortical neurons.
    The Journal of biological chemistry, 1994, Jan-14, Volume: 269, Issue:2

    Topics: Androstanes; Animals; Azasteroids; Blotting, Western; Cells, Cultured; Cerebral Cortex; Chick Embryo; Down-Regulation; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Molecular Weight; Neurons; Receptors, GABA-A

1994
GABA, THIP and baclofen inhibition of Purkinje cells and cerebellar nuclei neurons.
    Neuroscience research, 1993, Volume: 16, Issue:1

    Topics: Animals; Baclofen; Cerebellar Nuclei; Dose-Response Relationship, Drug; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Neural Inhibition; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley

1993
A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin.
    Clinical and experimental pharmacology & physiology, 1993, Volume: 20, Issue:3

    Topics: Analgesics; Animals; Flavonoids; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Pain Measurement; Parasympathetic Nervous System; Parasympathomimetics

1993
Depletion of polyamines prevents the neurotrophic activity of the GABA-agonist THIP in cultured rat cerebellar granule cells.
    Neurochemical research, 1993, Volume: 18, Issue:2

    Topics: Animals; Biogenic Polyamines; Cells, Cultured; Cerebellum; Eflornithine; Isoxazoles; Microscopy, Electron; Ornithine Decarboxylase Inhibitors; Rats; Rats, Sprague-Dawley

1993
Reduced function of gamma-aminobutyric acidA receptors in tottering mouse brain: role of cAMP-dependent protein kinase.
    Epilepsy research, 1995, Volume: 22, Issue:1

    Topics: Animals; Brain Chemistry; Chloride Channels; Chlorine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isoquinolines; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Protein Kinase Inhibitors; Radioisotopes; Receptors, GABA-A; Sulfonamides

1995
Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei.
    Journal of neurophysiology, 1996, Volume: 76, Issue:1

    Topics: Animals; Cerebellum; Enzyme Inhibitors; Evoked Potentials; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Long-Term Potentiation; Male; Marine Toxins; Microcystins; Neurons; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Synaptic Transmission

1996
The GABAA agonist THIP (gaboxadol) increases non-REM sleep and enhances delta activity in the rat.
    Neuroreport, 1996, Sep-02, Volume: 7, Issue:13

    Topics: Animals; Delta Rhythm; Electroencephalography; Electromyography; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Sleep Stages; Sleep, REM; Wakefulness

1996
pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor.
    Brain research, 1996, Nov-11, Volume: 739, Issue:1-2

    Topics: Acrylates; Animals; Drosophila melanogaster; Female; GABA Agonists; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Isoxazoles; Oocytes; Receptors, GABA; Recombinant Proteins; Xenopus

1996
N-ethylmaleimide blocks depolarization-induced suppression of inhibition and enhances GABA release in the rat hippocampal slice in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Feb-01, Volume: 17, Issue:3

    Topics: Analysis of Variance; Animals; Baclofen; Ethylmaleimide; Evoked Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA

1997
Neuronal regulation of astrocyte morphology in vitro is mediated by GABAergic signaling.
    Glia, 1997, Volume: 20, Issue:1

    Topics: Animals; Animals, Newborn; Astrocytes; Baclofen; Bicuculline; Cell Adhesion; Cells, Cultured; Coculture Techniques; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Isoxazoles; Muscimol; Neurons; Rats; Rats, Wistar; Signal Transduction; Sodium Channel Blockers; Tetrodotoxin; Time Factors

1997
GABAergic drugs and socio-sexual behavior.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:2

    Topics: Animals; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Rats; Rats, Wistar; Sexual Behavior, Animal; Social Behavior; Valproic Acid

1997
Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.
    Molecular pharmacology, 1997, Volume: 52, Issue:6

    Topics: Animals; Binding, Competitive; DNA, Complementary; Electrophysiology; GABA Agonists; GABA Antagonists; Humans; Isoxazoles; Kinetics; Macromolecular Substances; Muscimol; Oocytes; Piperidines; Receptors, GABA-A; Transduction, Genetic; Transfection; Tritium; Xenopus laevis

1997
THIP, a selective gamma-aminobutyric acid receptor agonist, alters flash-evoked potentials in rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:4

    Topics: Animals; Body Temperature; Electrophysiology; Evoked Potentials, Visual; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Photic Stimulation; Rats; Superior Colliculi; Visual Cortex

1997
gamma-Aminobutyric acidA agonists differentially augment gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1

    Topics: Animals; Behavior, Animal; Benzazepines; Cocaine; Dopamine Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Piperazines

1998
Neurosteroid inhibition of cell death.
    The American journal of physiology, 1997, Volume: 273, Issue:6

    Topics: Alkaloids; Animals; Antimycin A; Benzylisoquinolines; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Dehydroepiandrosterone Sulfate; Female; gamma-Aminobutyric Acid; Isoxazoles; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Mitochondria; Muscimol; Oxygen Consumption; Pregnanes; Rabbits; Receptors, GABA-A

1997
Expression of the GABA(A) receptor alpha6 subunit in cultured cerebellar granule cells is developmentally regulated by activation of GABA(A) receptors.
    Journal of neuroscience research, 1997, Dec-15, Volume: 50, Issue:6

    Topics: Animals; Cells, Cultured; Cerebellum; GABA Agonists; Gene Expression Regulation, Developmental; Isoxazoles; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, GABA-A

1997
The GABA(A) agonist THIP increases non-REM sleep and enhances non-REM sleep-specific delta activity in the rat during the dark period.
    Sleep, 1997, Volume: 20, Issue:12

    Topics: Animals; Circadian Rhythm; Delta Rhythm; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; GABA Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Sleep, REM; Wakefulness

1997
[Receptor mechanism of the neuroprotective effect of GABAergic agents].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:2

    Topics: Animals; Baclofen; Brain Ischemia; Female; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Injections, Subcutaneous; Isonipecotic Acids; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscimol; Neuroprotective Agents; Receptors, GABA-A; Receptors, GABA-B

1998
Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors.
    Journal of neuroscience research, 1998, May-01, Volume: 52, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hexachlorocyclohexane; Insecticides; Isoxazoles; Mice; Mitochondria; Neurons; Synaptic Transmission; Tetrazolium Salts; Thiazoles

1998
The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: Amphetamine; Animals; Bicuculline; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Frontal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Models, Neurological; Motor Activity; Stereotyped Behavior; Sulpiride

1998
Effects of the GABA agonists baclofen and THIP on long-term compensation in hemilabyrinthectomised rats.
    Brain research, 1998, Jun-08, Volume: 795, Issue:1-2

    Topics: Animals; Baclofen; Ear, Inner; Eye Movements; Functional Laterality; GABA Agonists; Isoxazoles; Magnetics; Nystagmus, Pathologic; Rats; Rats, Inbred Strains; Reflex, Vestibulo-Ocular

1998
GABAergic drugs and sexual behaviour in the rabbit: evidence for species-specific effects.
    Journal of psychopharmacology (Oxford, England), 1998, Volume: 12, Issue:2

    Topics: Animals; Baclofen; Bicuculline; Copulation; Dose-Response Relationship, Drug; Escape Reaction; GABA Agents; Isoxazoles; Male; Picrotoxin; Rabbits; Rats; Sexual Behavior, Animal; Species Specificity; Structure-Activity Relationship

1998
Defining affinity with the GABAA receptor.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Nov-01, Volume: 18, Issue:21

    Topics: Animals; Animals, Newborn; beta-Alanine; Cells, Cultured; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Ligands; Muscimol; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Receptors, GABA-A

1998
Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice.
    Psychopharmacology, 1999, Volume: 141, Issue:2

    Topics: Analysis of Variance; Animals; Baclofen; Central Nervous System Stimulants; Ethanol; GABA Agonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Isoxazoles; Mice; Mice, Inbred DBA; Motor Activity; Receptors, GABA-A; Receptors, GABA-B

1999
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
    Psychopharmacology, 1999, Volume: 141, Issue:4

    Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A

1999
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
    Epilepsy research, 1999, Volume: 35, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Isoxazoles; Male; Microinjections; Naloxone; Narcotic Antagonists; Nerve Net; Periaqueductal Gray; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Seizures

1999
GABA agonists differentially modify blood glucose levels of diabetic rats.
    Japanese journal of pharmacology, 1999, Volume: 80, Issue:4

    Topics: Aminooxyacetic Acid; Animals; Baclofen; Benzodiazepines; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Female; GABA Agonists; Insulin; Isoxazoles; Rats; Rats, Wistar

1999
Channel properties determine the transient activation kinetics of recombinant GABA(A) receptors.
    Brain research. Molecular brain research, 1999, Nov-10, Volume: 73, Issue:1-2

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Membrane Potentials; Protein Isoforms; Receptors, GABA-A; Recombinant Fusion Proteins; Time Factors

1999
Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor.
    Neuroscience, 2000, Volume: 95, Issue:3

    Topics: Animals; Baclofen; GABA Agonists; Hot Temperature; Injections, Spinal; Injections, Subcutaneous; Isonicotinic Acids; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nociceptors; Physical Stimulation; Protein Isoforms; Receptors, GABA-A; Sensory Thresholds; Sex Characteristics

2000
gamma-aminobutyric Acid(A) (GABA(A)) agonist 4,5,6, 7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol persistently increases sleep maintenance and intensity during chronic administration to rats.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:3

    Topics: Animals; Electroencephalography; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Sleep

2000
Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors.
    European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2

    Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Entropy; GABA Agonists; GABA Antagonists; Humans; Isoxazoles; L Cells; Membranes; Mice; Muscimol; Piperidines; Pyridazines; Receptors, GABA-A; Recombinant Proteins; Temperature; Tritium

2001
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
    Bulletin of experimental biology and medicine, 2000, Volume: 130, Issue:8

    Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred CBA; Muscimol; Neuroprotective Agents; Picrotoxin

2000
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:8

    Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Neurotransmitter Agents; Psychotic Disorders; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission

2000
Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.
    British journal of pharmacology, 2001, Volume: 133, Issue:4

    Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Cerebral Cortex; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Oocytes; Patch-Clamp Techniques; Piperidines; Pyridazines; Receptors, GABA-A; Xenopus laevis

2001
Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects.
    American journal of physiology. Endocrinology and metabolism, 2001, Volume: 281, Issue:1

    Topics: Aged; Double-Blind Method; Electroencephalography; Female; GABA Agonists; GABA-A Receptor Agonists; Hormones; Humans; Isoxazoles; Male; Middle Aged; Sleep; Sleep, REM; Wakefulness

2001
Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.
    Biophysical journal, 2001, Volume: 81, Issue:5

    Topics: Animals; Brain; Diffusion; Electrophysiology; Energy Metabolism; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Inhibitory Concentration 50; Isoxazoles; Kinetics; Muscimol; Phosphinic Acids; Protein Binding; Pyridazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2001
Opposite roles of GABA and excitatory amino acids on the control of GAD expression in cultured retina cells.
    Brain research, 2002, Jan-18, Volume: 925, Issue:1

    Topics: Animals; Baclofen; Cells, Cultured; Chick Embryo; Cytarabine; Excitatory Amino Acid Agonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoxazoles; Kainic Acid; Nitric Oxide; Retina

2002
Inhibition of THIP on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity.
    Archives of pharmacal research, 2002, Volume: 25, Issue:2

    Topics: Animals; Drug Tolerance; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Receptors, Dopamine

2002
Characterization of GABA(A) receptor ligands in the rat cortical wedge preparation: evidence for action at extrasynaptic receptors?
    British journal of pharmacology, 2002, Volume: 137, Issue:1

    Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoxazoles; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synapses

2002
GABAergic and glutamatergic terminals differentially influence the organization of GABAergic synapses in rat cerebellar granule cells in vitro.
    Neuroscience, 2002, Volume: 114, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cerebellar Cortex; Fluorescent Antibody Technique; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Presynaptic Terminals; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes; Synaptic Transmission; Vesicular Glutamate Transport Protein 1; Vesicular Transport Proteins

2002
Gamma-aminobutyric acid-induced calcium signalling in rat superior collicular neurones.
    Neuroscience letters, 2002, Dec-13, Volume: 334, Issue:2

    Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Cytarabine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Neurons; Phosphinic Acids; Pyridines; Rats; Receptors, GABA; Superior Colliculi

2002
Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Central Nervous System Depressants; Chlorides; Ethanol; Etomidate; Female; Flurazepam; GABA Agonists; GABA Modulators; Gene Deletion; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Mice, Knockout; Pentobarbital; Postural Balance; Pyridines; Receptors, GABA; Receptors, GABA-A; Sex Characteristics; Sleep; Time Factors; Zolpidem

2003
Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4betadelta GABA(A) receptors.
    Neuroreport, 2003, Jan-20, Volume: 14, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Drug Implants; Female; GABA Agonists; Hippocampus; Ion Channels; Isoxazoles; Maze Learning; Pentobarbital; Premenstrual Syndrome; Progesterone; Protein Isoforms; Protein Subunits; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome

2003
Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Action Potentials; Animals; Benzodiazepines; Binding Sites; Cerebral Cortex; Drug Synergism; Ethanol; Female; GABA Agonists; Humans; In Vitro Techniques; Isoxazoles; Male; Neocortex; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus laevis

2003
The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures.
    Brain research, 2003, May-30, Volume: 973, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Hippocampus; Isoxazoles; Kainic Acid; Muscimol; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Propidium; Pyramidal Cells; Rats; Rats, Wistar; Time Factors

2003
Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.
    Molecular and cellular neurosciences, 2003, Volume: 24, Issue:1

    Topics: Animals; Chloride Channels; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Pyramidal Cells; Rats; Reaction Time; Receptors, GABA-A; Synaptic Transmission

2003
Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors.
    European journal of pharmacology, 2003, Sep-30, Volume: 478, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Membrane Potentials; Neural Inhibition; Protein Subunits; Rats; Receptors, GABA-A

2003
Aza-THIP and related analogues of THIP as GABA C antagonists.
    Bioorganic & medicinal chemistry, 2003, Nov-17, Volume: 11, Issue:23

    Topics: Animals; Aza Compounds; GABA Antagonists; Humans; Isoxazoles; Kinetics; Magnetic Resonance Spectroscopy; Receptors, GABA; Recombinant Proteins; Xenopus

2003
Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance.
    European journal of pharmacology, 2003, Dec-15, Volume: 482, Issue:1-3

    Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Ethanol; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test

2003
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.
    British journal of pharmacology, 2004, Volume: 141, Issue:1

    Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Body Temperature Regulation; Electroencephalography; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Isoxazoles; Lateral Ventricles; Male; Muscimol; Nipecotic Acids; Preoptic Area; Rabbits; Receptors, GABA-A; Receptors, GABA-B; Rectum; Somatosensory Cortex

2004
Estradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat.
    Psychopharmacology, 2004, Volume: 172, Issue:3

    Topics: Anesthesia; Anesthetics; Animals; Drug Interactions; Estradiol; Female; GABA Agonists; Isoxazoles; Male; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Reflex; Sex Characteristics; Testosterone

2004
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A

2004
Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3

    Topics: Animals; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Deletion; Isoxazoles; Mice; Protein Subunits; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, GABA-A; Reflex; Tritium

2004
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3

    Topics: Alcoholism; Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; GABA Agonists; Hippocampus; Isoxazoles; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Zolpidem

2004
Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:8

    Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Isoxazoles; Male; Mice; Nitric Oxide Synthase; Nitroarginine; Pyrazoles; Pyridazines

2004
Gaboxadol. Lundbeck/Merck.
    Current opinion in investigational drugs (London, England : 2000), 2004, Volume: 5, Issue:7

    Topics: Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dogs; Drug Evaluation, Preclinical; Drug Industry; GABA Agonists; Humans; Isoxazoles; Molecular Structure; Multicenter Studies as Topic; Patents as Topic; Randomized Controlled Trials as Topic; Rats; Sleep Initiation and Maintenance Disorders; Switzerland

2004
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
    Biochemical pharmacology, 2004, Oct-15, Volume: 68, Issue:8

    Topics: Analgesics, Non-Narcotic; Anxiety; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Hypnotics and Sedatives; Isoxazoles; Piperidines; Sleep Wake Disorders

2004
Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.
    The Journal of biological chemistry, 2004, Dec-24, Volume: 279, Issue:52

    Topics: Amino Acid Sequence; Amino Acids, Cyclic; Binding Sites; Carboxylic Acids; Cations; Crotonates; Cyclopropanes; Dose-Response Relationship, Drug; Electric Conductivity; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Imidazoles; Ion Channel Gating; Isoxazoles; Molecular Sequence Data; Molecular Structure; Muscimol; Mutagenesis, Site-Directed; Proline; Protein Subunits; Receptors, GABA; Static Electricity; Structure-Activity Relationship

2004
Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density.
    The European journal of neuroscience, 2005, Volume: 21, Issue:2

    Topics: Animals; Antibodies; Blotting, Western; Brain; Carrier Proteins; Cells, Cultured; Clathrin-Coated Vesicles; Dynamins; Embryo, Mammalian; Extracellular Space; GABA-A Receptor Antagonists; Glucose Solution, Hypertonic; Immunohistochemistry; Isoxazoles; Membrane Proteins; Neurons; Peptides; Protein Subunits; Rats; Receptors, AMPA; Receptors, GABA-A; Synapses; Synapsins; Synaptic Transmission; Temperature; Time Factors

2005
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.
    Psychopharmacology, 2005, Volume: 178, Issue:4

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women

2005
The GABAA receptor agonist THIP alters the EEG in waking and sleep of mice.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Female; GABA Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Reaction Time; Sleep; Wakefulness

2005
Effects of gabaergic drugs on reserpine-induced oral dyskinesia.
    Behavioural brain research, 2005, May-07, Volume: 160, Issue:1

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Baclofen; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; GABA Agents; Immobility Response, Tonic; Isoxazoles; Locomotion; Male; Rats; Rats, Wistar; Reserpine

2005
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Apr-20, Volume: 25, Issue:16

    Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Ataxia; Behavior, Animal; Blotting, Western; Calcium; Central Nervous System Depressants; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Activation; Ethanol; Excitatory Amino Acid Antagonists; Food Preferences; GABA Agonists; Isoxazoles; Ketamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pentobarbital; Phosphorylation; Psychomotor Performance; Quinine; Reaction Time; Reflex; Saccharin; Sleep

2005
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
    European journal of pharmacology, 2005, Jun-01, Volume: 516, Issue:2

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neuralgia; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Mechanical; Time Factors; Trauma, Nervous System; Zolpidem

2005
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects.
    Neuropharmacology, 2005, Volume: 49, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Blotting, Western; Cell Separation; Electrophysiology; Estradiol; Female; GABA Agonists; GABA Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Isoxazoles; Lanthanum; Lorazepam; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Steroids

2005
Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons.
    Journal of neurochemistry, 2005, Volume: 94, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Central Nervous System Depressants; Cerebellum; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Ethanol; GABA Agonists; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Isoxazoles; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2005
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.
    Journal of neurophysiology, 2005, Volume: 94, Issue:6

    Topics: Action Potentials; Animals; Animals, Newborn; Azides; Benzodiazepines; Bicuculline; Blotting, Western; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Humans; Immunohistochemistry; Immunoprecipitation; In Vitro Techniques; Indoles; Isoxazoles; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Patch-Clamp Techniques; Prokaryotic Initiation Factors; Protein Subunits; Pyridines; Receptors, GABA-A; Synapses; Synaptophysin; Transfection; Ventral Thalamic Nuclei; Zinc Compounds; Zolpidem

2005
THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex.
    Cerebral cortex (New York, N.Y. : 1991), 2006, Volume: 16, Issue:8

    Topics: Analgesics; Animals; Animals, Newborn; Cells, Cultured; Electric Conductivity; Excitatory Postsynaptic Potentials; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neocortex; Neurons; Receptors, GABA-A; Synaptic Transmission

2006
Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lanthanum; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis; Zinc

2006
Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.
    BMC pharmacology, 2006, Jan-13, Volume: 6

    Topics: Animals; Anticonvulsants; Electrophysiology; Etomidate; GABA Modulators; Humans; Hypnotics and Sedatives; Isoxazoles; Oocytes; Patch-Clamp Techniques; Propofol; Receptors, GABA-A; Xenopus

2006
Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex.
    Brain research, 2006, Feb-16, Volume: 1073-1074

    Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Morphine; Muscimol; Narcotics; Neurons; Nociceptors; Pain Measurement; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time

2006
The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2007, Jan-15, Volume: 17, Issue:2

    Topics: Action Potentials; Analysis of Variance; Anesthetics; Animals; Drug Interactions; Female; GABA Agonists; In Vitro Techniques; Isoxazoles; Muscimol; Neural Inhibition; Neurons; Pregnanolone; Progesterone; Raphe Nuclei; Rats; Receptors, GABA-A; Serotonin; Time Factors

2007
delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol.
    European journal of pharmacology, 2006, Jul-17, Volume: 541, Issue:3

    Topics: Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Female; GABA Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscimol; Receptors, GABA-A

2006
KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:4

    Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Diazepam; Ethanol; Exploratory Behavior; Hippocampus; Immobility Response, Tonic; In Vitro Techniques; Isoxazoles; K Cl- Cotransporters; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Skills Disorders; Neurons; Symporters

2007
GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Oct-10, Volume: 103, Issue:41

    Topics: Animals; Dentate Gyrus; GABA-A Receptor Agonists; Isoxazoles; Mice; Mice, Knockout; Receptors, GABA-A; Thalamus

2006
A single point mutation of the GABA(A) receptor alpha5-subunit confers fluoxetine sensitivity.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Amino Acid Substitution; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fluoxetine; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Xenopus laevis

2007
Auto-modulation of neuroactive steroids on GABA A receptors: a novel pharmacological effect.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Membrane Potentials; Patch-Clamp Techniques; Pregnanediones; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Steroids

2007
Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study.
    Neuropharmacology, 2007, Volume: 52, Issue:3

    Topics: Animals; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; GABA Agonists; Generalization, Psychological; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Sleep

2007
Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex.
    Journal of neurophysiology, 2007, Volume: 97, Issue:3

    Topics: Animals; Dose-Response Relationship, Radiation; Drug Interactions; GABA Agonists; GABA Modulators; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Membrane Potentials; Mice; Neocortex; Neurons; Patch-Clamp Techniques; Reaction Time; Receptors, GABA-A

2007
Lack of generalisation between the GABAA receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure.
    Psychopharmacology, 2007, Volume: 193, Issue:1

    Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Discrimination Learning; Drug Interactions; GABA-A Receptor Agonists; Generalization, Psychological; Isoxazoles; Male; Rats; Rats, Wistar

2007
Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration.
    European journal of pharmacology, 2007, May-07, Volume: 562, Issue:1-2

    Topics: Animals; Central Nervous System; Chromatography, Liquid; GABA Agonists; Infusion Pumps; Injections, Subcutaneous; Isoxazoles; Male; Mass Spectrometry; Microdialysis; Rats; Rats, Wistar; Time Factors

2007
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
    European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3

    Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Isoxazoles; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Pharmacogenetics; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Reproducibility of Results; Species Specificity

2007
The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors.
    The European journal of neuroscience, 2007, Volume: 25, Issue:6

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; GABA Agonists; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Reaction Time; Receptors, GABA-A; Sleep; Wakefulness

2007
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
    The Journal of physiology, 2007, Jul-15, Volume: 582, Issue:Pt 2

    Topics: Animals; Bicuculline; Electrophysiology; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Medulla Oblongata; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Synapses

2007
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
    Brain research, 2007, Sep-19, Volume: 1170

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Subcellular Fractions

2007
GABAergic modulation of binge-like ethanol intake in C57BL/6J mice.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 88, Issue:1

    Topics: Alcoholism; Animals; Baclofen; Central Nervous System Depressants; Darkness; Dose-Response Relationship, Drug; Ethanol; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Postural Balance

2007
Development and validation of a selective and sensitive bioanalytical procedure for the quantitative determination of gaboxadol in human plasma employing mixed mode solid phase extraction and hydrophilic interaction liquid chromatography with tandem mass
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Oct-15, Volume: 858, Issue:1-2

    Topics: Chromatography, Liquid; Humans; Isoxazoles; Molecular Structure; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry

2007
Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors.
    Journal of neurochemistry, 2008, Volume: 105, Issue:2

    Topics: Animals; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dark Adaptation; Dose-Response Relationship, Drug; Exploratory Behavior; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Isoxazoles; Male; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Binding; Protein Subunits; Reaction Time; Receptors, GABA-A; Reflex; Thy-1 Antigens; Transfection

2008
The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.
    The Journal of physiology, 2008, Feb-15, Volume: 586, Issue:4

    Topics: Animals; Dentate Gyrus; Diazepam; Female; GABA Agonists; GABA Modulators; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Protein Isoforms; Receptors, GABA; Receptors, GABA-A; Synapses

2008
Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors.
    The Journal of general physiology, 2008, Volume: 131, Issue:2

    Topics: Animals; Cell Line; Computer Simulation; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Isoxazoles; Kinetics; Membrane Potentials; Mice; Models, Chemical; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; Transfection

2008
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem

2008
Sleep-stabilizing effects of E-6199, compared to zopiclone, zolpidem and THIP in mice.
    Sleep, 2008, Volume: 31, Issue:2

    Topics: Animals; Azabicyclo Compounds; Electroencephalography; Hypnotics and Sedatives; Isoxazoles; Mice; Piperazines; Polysomnography; Pyridines; Sleep; Sleep Stages; Sleep Wake Disorders; Zolpidem

2008
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:1

    Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Electrodes, Implanted; Electroencephalography; GABA Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep

2008
Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep-wakefulness: role of delta-subunit containing extrasynaptic GABAA receptors.
    Neuroscience, 2008, May-15, Volume: 153, Issue:3

    Topics: Animals; GABA Agonists; Hypothalamus; Injections, Intraventricular; Isoxazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Wakefulness

2008
Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex.
    Journal of neurophysiology, 2008, Volume: 100, Issue:1

    Topics: Anesthetics; Animals; Animals, Newborn; Desoxycorticosterone; Drug Interactions; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Neocortex; Neural Inhibition; Neurons; Patch-Clamp Techniques; Reaction Time; Receptors, GABA-A

2008
Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
    Journal of neurophysiology, 2008, Volume: 100, Issue:2

    Topics: Action Potentials; Animals; Cerebral Cortex; Dose-Response Relationship, Radiation; Electric Stimulation; Female; GABA Agonists; In Vitro Techniques; Isoxazoles; Lysine; Male; Mice; Mice, Inbred C57BL; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Thalamus

2008
Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol.
    Neuroscience letters, 2008, Jul-11, Volume: 439, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Drug Interactions; Ethanol; GABA Agonists; Hypothalamus; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Up-Regulation

2008
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.
    The European journal of neuroscience, 2008, Volume: 27, Issue:12

    Topics: Animals; Cerebral Cortex; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Homeostasis; Isoxazoles; Long-Term Potentiation; Models, Neurological; Neural Inhibition; Neuronal Plasticity; Organ Culture Techniques; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission

2008
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.
    Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15

    Topics: Animals; Binding Sites; Brain; Cell Line; Electrophysiology; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis

2008
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:3

    Topics: Allosteric Regulation; Animals; Benzimidazoles; Benzodiazepinones; Diazepam; GABA Modulators; Humans; Inflammation; Isoxazoles; Neuralgia; Pyridines; Rats; Receptors, GABA-A; Zolpidem

2008
Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.
    Pharmaceutical research, 2009, Volume: 26, Issue:2

    Topics: Administration, Oral; Animals; Biotransformation; CHO Cells; Chromatography, Liquid; Cricetinae; Cricetulus; GABA Agonists; Glucuronides; Glucuronosyltransferase; Humans; Isoenzymes; Isoxazoles; Kidney; Liver; Membrane Transport Proteins; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Recombinant Proteins; Tandem Mass Spectrometry; Transfection; UDP-Glucuronosyltransferase 1A9

2009
Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique.
    Journal of neuroscience methods, 2009, Apr-15, Volume: 178, Issue:2

    Topics: Animals; Brain; Central Nervous System Agents; Citalopram; Extracellular Space; Isoxazoles; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Wistar

2009
Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress.
    Psychopharmacology, 2009, Volume: 204, Issue:2

    Topics: Acute Disease; Anesthetics; Animals; Anti-Anxiety Agents; Body Temperature; Carbolines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA Agents; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Motor Activity; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Psychological; Telemetry; Zolpidem

2009
Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:5

    Topics: Animals; Circadian Rhythm; Cricetinae; GABA Agonists; GABA-A Receptor Agonists; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Mesocricetus; Muscimol; Period Circadian Proteins; Photoperiod; Receptors, GABA-A; RNA, Messenger; Suprachiasmatic Nucleus

2009
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.
    The European journal of neuroscience, 2009, Volume: 29, Issue:6

    Topics: Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Agonists; GABA Antagonists; Glycine Agents; In Vitro Techniques; Isoxazoles; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neural Inhibition; Patch-Clamp Techniques; Receptors, GABA-A; Strychnine; Thalamus; Time Factors

2009
The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning.
    The Spanish journal of psychology, 2009, Volume: 12, Issue:1

    Topics: Anesthetics; Animals; Behavior, Animal; Brain; Conditioning, Classical; Electroshock; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Learning; Motor Activity; Neural Inhibition; Photic Stimulation; Rabbits; Receptors, GABA-B

2009
Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:6

    Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Flumazenil; GABA Modulators; Isoxazoles; Lorazepam; Male; Maze Learning; Midazolam; Motor Activity; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A

2009
The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:11

    Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Neural Inhibition; Neurons; Neurotransmitter Agents; Raphe Nuclei; Rats; Receptors, GABA-A; Serotonin

2010
Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem.
    Journal of sleep research, 2009, Volume: 18, Issue:4

    Topics: Adult; Affect; Arousal; Attention; Automobile Driving; Azabicyclo Compounds; Cognition; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Humans; Isoxazoles; Male; Memory, Short-Term; Neuropsychological Tests; Orientation; Piperazines; Postural Balance; Psychomotor Performance; Pyridines; Reaction Time; Retention, Psychology; Sleep Initiation and Maintenance Disorders; Young Adult; Zolpidem

2009
Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan.
    British journal of pharmacology, 2009, Volume: 157, Issue:8

    Topics: Administration, Oral; Amino Acid Transport Systems; Animals; Area Under Curve; Biological Availability; Caco-2 Cells; Dogs; Drug Interactions; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Intestinal Absorption; Isoxazoles; Male; Symporters; Tissue Distribution; Tryptophan

2009
Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.
    Journal of neurochemistry, 2009, Volume: 111, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Biophysical Phenomena; Central Nervous System Depressants; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethanol; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Transfection; Xenopus

2009
5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Jan-31, Volume: 39, Issue:1-3

    Topics: 5-Hydroxytryptophan; Amino Acid Transport Systems; Animals; Biological Transport; Caco-2 Cells; Drug Interactions; Gastric Emptying; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Male; Oocytes; Organic Anion Transport Protein 1; Rats; Rats, Sprague-Dawley; Symporters; Xenopus laevis

2010
Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus.
    The European journal of neuroscience, 2009, Volume: 30, Issue:11

    Topics: Action Potentials; Anesthetics; Animals; Animals, Newborn; Biophysics; Electric Stimulation; GABA Agonists; Glycine; Hypoglossal Nerve; Isoxazoles; Medulla Oblongata; Motor Neurons; Patch-Clamp Techniques; Pregnanolone; Progesterone; Progestins; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission

2009
Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.
    Addiction biology, 2010, Volume: 15, Issue:1

    Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Animals; Benzodiazepines; Brain; Crosses, Genetic; Ethanol; Flurazepam; GABA Agonists; Genotype; Glutamate Decarboxylase; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Neurologic Mutants; Motor Skills; Phenotype; Postural Balance; Species Specificity; Taste

2010
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
    Hippocampus, 2011, Volume: 21, Issue:4

    Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Male; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors

2011
Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.
    The Journal of physiology, 2010, Apr-15, Volume: 588, Issue:Pt 8

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Fibroblasts; GABA Agonists; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Isoxazoles; Kidney; Mice; Muscimol; Patch-Clamp Techniques; Receptors, GABA-A; Synapses; Transfection

2010
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
    Neurobiology of disease, 2010, Volume: 38, Issue:3

    Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Temperature; Time Factors

2010
Pulvinar inactivation disrupts selection of movement plans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jun-23, Volume: 30, Issue:25

    Topics: Animals; Behavior, Animal; Brain Mapping; Decision Making; Electrophysiology; Eye Movements; Female; GABA Agonists; Isoxazoles; Macaca mulatta; Magnetic Resonance Imaging; Male; Motor Activity; Muscimol; Neurons; Pulvinar; Visual Fields

2010
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jul-21, Volume: 30, Issue:29

    Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Interneurons; Isoxazoles; Male; Mice; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Synaptic Transmission

2010
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
    Neuropharmacology, 2011, Volume: 60, Issue:7-8

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex

2011
Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.
    Psychopharmacology, 2011, Volume: 214, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Exploratory Behavior; Female; GABA-A Receptor Agonists; Isoxazoles; Motor Activity; Phencyclidine; Rats; Receptors, GABA-A; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Time Factors

2011
Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Feb-14, Volume: 42, Issue:3

    Topics: Amino Acid Transport Systems; Caco-2 Cells; GABA Agonists; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Isoxazoles; Models, Molecular; Symporters

2011
Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.
    Behavioural brain research, 2011, Jun-01, Volume: 219, Issue:2

    Topics: Animals; Association Learning; Electrophysiological Phenomena; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Interneurons; Isoxazoles; Male; Mice; Neural Conduction; Neurons; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Sex Characteristics; Somatosensory Cortex

2011
Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus.
    PloS one, 2011, Jan-26, Volume: 6, Issue:1

    Topics: Animals; Auditory Pathways; Isoxazoles; Neural Inhibition; Protein Subunits; Rats; Receptors, GABA-A; Thalamus

2011
Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Action Potentials; Analgesics; Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Formaldehyde; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hindlimb Suspension; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Pain Measurement; Psychomotor Performance; Receptors, GABA-A; Sensory Receptor Cells; Spinal Cord

2011
Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; GABA Modulators; Isoxazoles; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mimosa; N-Methylaspartate; Phytotherapy; Plant Extracts; Raphe Nuclei; Receptors, GABA-A; Serotonin

2012
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:1

    Topics: Animals; Anticonvulsants; Ataxia; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Plasma Membrane Transport Proteins; Isoxazoles; Male; Mice; Nipecotic Acids; Receptors, GABA-A; Synapses; Tiagabine

2011
Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.
    Neurobiology of disease, 2011, Volume: 43, Issue:3

    Topics: Animals; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Patch-Clamp Techniques; Purkinje Cells; Receptor Aggregation; Receptors, GABA-A; Synaptic Potentials

2011
Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol.
    Alcoholism, clinical and experimental research, 2011, Volume: 35, Issue:11

    Topics: Alcohol Drinking; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Finasteride; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Models, Animal; Pregnanolone; Receptors, GABA-A

2011
Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.
    Journal of neurophysiology, 2011, Volume: 106, Issue:4

    Topics: Animals; Cerebellar Cortex; Dose-Response Relationship, Drug; GABA Agonists; GABAergic Neurons; HEK293 Cells; Humans; Isoxazoles; Mice; Mice, Knockout; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Protein Multimerization; Protein Subunits; Receptors, GABA-A; Recombinant Fusion Proteins; Solubility; Xenopus laevis

2011
Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Jan-15, Volume: 302, Issue:2

    Topics: Animals; Asthma; Benzodiazepines; Cell Line; Chlorides; GABA-A Receptor Agonists; Guinea Pigs; Humans; Isoxazoles; Laser Capture Microdissection; Ligands; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Receptors, GABA-A; RNA, Messenger; Taurine; Trachea

2012
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
    Developmental neuroscience, 2011, Volume: 33, Issue:5

    Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Neuropsychological Tests; Receptors, GABA-A

2011
Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors.
    Journal of neurophysiology, 2012, Volume: 107, Issue:3

    Topics: Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Sodium Channel Blockers; Solitary Nucleus; Tetrodotoxin

2012
Effects of general anaesthetics on 5-HT neuronal activity in the dorsal raphe nucleus.
    Neuropharmacology, 2012, Volume: 62, Issue:4

    Topics: Action Potentials; Anesthetics, General; Animals; Chloral Hydrate; Hypnotics and Sedatives; Isoxazoles; Ketamine; Male; N-Methylaspartate; Pentobarbital; Raphe Nuclei; Rats; Serotonergic Neurons; Serotonin; Urethane

2012
Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons.
    Neuroscience, 2012, Apr-19, Volume: 208

    Topics: Animals; Bicuculline; Blotting, Western; Cells, Cultured; Crotonates; Electrophysiological Phenomena; GABA Agonists; GABA Antagonists; Ganglia, Spinal; Isoxazoles; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Time Factors; Up-Regulation

2012
Synergistic antidepressant-like action of gaboxadol and escitalopram.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:10

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; Drug Resistance; Drug Synergism; Drug Therapy, Combination; GABA-A Receptor Agonists; Isoxazoles; Male; Neurogenesis; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Up-Regulation

2012
Intracellular chloride concentration influences the GABAA receptor subunit composition.
    Nature communications, 2012, Mar-13, Volume: 3

    Topics: Animals; Bumetanide; Carboxylic Acids; Cells, Cultured; Cerebellum; Chlorides; gamma-Aminobutyric Acid; Indenes; Isoxazoles; K Cl- Cotransporters; Mice; Neurons; Patch-Clamp Techniques; Protein Subunits; Pyridines; Receptors, GABA-A; RNA Interference; RNA, Small Interfering; Symporters; Zolpidem

2012
GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Apr-11, Volume: 32, Issue:15

    Topics: Animals; Behavior, Animal; Dopaminergic Neurons; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; GABA Agonists; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuronal Plasticity; Papio; Polymerase Chain Reaction; Receptors, AMPA; Receptors, GABA-A; Reward; Self Administration; Substance-Related Disorders; Ventral Tegmental Area

2012
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    The journal of pain, 2012, Volume: 13, Issue:6

    Topics: Analgesia; Analgesics; Animals; Benzodiazepines; Chlorides; GABA-A Receptor Agonists; Isoxazoles; K Cl- Cotransporters; Male; Mice; Mice, Inbred ICR; Muscimol; Neuralgia; Peripheral Nerve Injuries; Pregnanolone; Receptors, GABA-A; Sciatic Nerve; Symporters

2012
Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Apr-25, Volume: 32, Issue:17

    Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Isoxazoles; Larva; Membrane Potentials; Models, Biological; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus

2012
Function and expression of the proton-coupled amino acid transporter PAT1 along the rat gastrointestinal tract: implications for intestinal absorption of gaboxadol.
    British journal of pharmacology, 2012, Volume: 167, Issue:3

    Topics: Administration, Oral; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Biological Availability; Biological Transport; Caco-2 Cells; Gastrointestinal Tract; Humans; Intestinal Absorption; Isoxazoles; Male; Proline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Symporters; Tryptophan; Xenopus laevis

2012
Positive modulation of δ-subunit containing GABA(A) receptors in mouse neurons.
    Neuropharmacology, 2012, Volume: 63, Issue:3

    Topics: Animals; Anxiety; Brain; Calcium; Data Interpretation, Statistical; Dentate Gyrus; Electrophysiological Phenomena; Fever; GABA Agents; GABA Agonists; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Radioligand Assay; Receptors, GABA-A; Stress, Psychological; Synaptic Transmission

2012
The role of GABAergic system on the inhibitory effect of ghrelin on food intake in neonatal chicks.
    Neuroscience letters, 2012, Jun-27, Volume: 520, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Chickens; Eating; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Ghrelin; Glutamate Decarboxylase; Injections, Intraventricular; Isoxazoles; Picrotoxin; Receptors, GABA-A; RNA, Messenger

2012
Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
    Neuropharmacology, 2012, Volume: 63, Issue:4

    Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drugs, Investigational; Ethanol; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Nootropic Agents; Pregnanolone; Protein Subunits; Receptors, GABA-A; Reinforcement, Psychology; Self Administration; Time Factors

2012
Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides.
    Molecular pharmaceutics, 2012, Sep-04, Volume: 9, Issue:9

    Topics: Administration, Oral; Amino Acid Transport Systems; Animals; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Dipeptides; Glycine; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Isoxazoles; Male; Oocytes; Protons; Rats; Rats, Sprague-Dawley; Symporters; Xenopus laevis

2012
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-08, Volume: 32, Issue:32

    Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Cerebellar Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Functional Laterality; GABA Agonists; GABA Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Ketamine; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Physical Stimulation; Pyridazines; Rats; Rats, Sprague-Dawley; Sensation; Vibrissae

2012
Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro.
    Brain research, 2013, Jan-15, Volume: 1490

    Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Central Nervous System Depressants; Diazepam; Electrophysiological Phenomena; Ethanol; GABA Modulators; Isoxazoles; Male; Membranes; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Thyroid Hormones; Thyroxine

2013
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
    Science translational medicine, 2012, Dec-05, Volume: 4, Issue:163

    Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Mice; Purkinje Cells; Ubiquitin-Protein Ligases

2012
Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.
    Sleep, 2013, Mar-01, Volume: 36, Issue:3

    Topics: Animals; Electroencephalography; GABA Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Microinjections; Muscimol; Pons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reticular Formation; Sleep; Sodium Chloride; Wakefulness

2013
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
    Molecular brain, 2013, May-01, Volume: 6

    Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission

2013
γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus.
    Annals of neurology, 2013, Volume: 74, Issue:4

    Topics: Analysis of Variance; Animals; Dentate Gyrus; Discrimination, Psychological; Electroshock; Exploratory Behavior; GABA Agonists; Isoxazoles; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Receptors, GABA-A; Recognition, Psychology

2013
Discriminative stimulus effects of pregnanolone in rhesus monkeys.
    Psychopharmacology, 2014, Volume: 231, Issue:1

    Topics: Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA Modulators; Gonadal Steroid Hormones; Hypnotics and Sedatives; Isoxazoles; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule

2014
Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.
    British journal of pharmacology, 2013, Volume: 170, Issue:5

    Topics: Administration, Oral; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Area Under Curve; Biological Availability; Caco-2 Cells; Chromatography; Dose-Response Relationship, Drug; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Male; Peptide Transporter 1; Proline; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sertraline; Sodium-Glucose Transporter 1; Symporters; Tandem Mass Spectrometry; Xenopus laevis

2013
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Action Potentials; Animals; Cerebellum; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glutamates; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Mice, Inbred C57BL; Neural Inhibition; Neurons; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Synapses; Synaptic Transmission

2013
Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus.
    Frontiers in neural circuits, 2013, Volume: 7

    Topics: Animals; Conditioning, Psychological; Cues; Fear; GABA Agonists; Hippocampus; Isoxazoles; Long-Term Potentiation; Maze Learning; Memory; Mice; Mice, Knockout; Receptors, GABA-A; Recognition, Psychology

2013
Modulation of stimulus-specific adaptation by GABA(A) receptor activation or blockade in the medial geniculate body of the anaesthetized rat.
    The Journal of physiology, 2014, Feb-15, Volume: 592, Issue:4

    Topics: Acoustic Stimulation; Adaptation, Physiological; Anesthesia, General; Animals; GABA Antagonists; GABA-A Receptor Agonists; GABAergic Neurons; Geniculate Bodies; Isoxazoles; Male; Pyridazines; Rats; Rats, Inbred F344; Receptors, GABA-A

2014
Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?
    Journal of neurophysiology, 2014, Volume: 111, Issue:2

    Topics: Animals; Chlorides; GABA-A Receptor Agonists; GABAergic Neurons; gamma-Aminobutyric Acid; Geniculate Bodies; Inferior Colliculi; Isoxazoles; Male; Rats; Rats, Inbred F344; Rats, Long-Evans; Receptors, GABA-A; Synapses; Synaptic Potentials

2014
Enantiotropically related polymorphs of gaboxadol hydrochloride.
    Acta crystallographica. Section C, Crystal structure communications, 2013, Volume: 69, Issue:Pt 11

    Topics: Crystallization; Isoxazoles; Models, Molecular; Temperature; X-Ray Diffraction

2013
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
    Journal of neuroendocrinology, 2014, Volume: 26, Issue:1

    Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation

2014
Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats.
    Neuropharmacology, 2014, Volume: 79

    Topics: Animals; Central Nervous System Depressants; Cerebellum; Developmental Disabilities; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Isoxazoles; Membrane Potentials; Motor Activity; Neurons; Pregnancy; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2014
Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics.
    Frontiers in neural circuits, 2013, Volume: 7

    Topics: Animals; Corpus Striatum; Female; GABA Agonists; Isoxazoles; Male; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; Synapses

2013
Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3.
    Frontiers in neural circuits, 2013, Volume: 7

    Topics: Animals; Anisoles; Astrocytes; Corpus Striatum; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Huntington Disease; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Transgenic; Neural Inhibition; Neurons; Nipecotic Acids; Patch-Clamp Techniques; Synaptic Transmission

2013
Excitatory/inhibitory equilibrium of the central amygdala nucleus gates anti-depressive and anxiolytic states in the hamster.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 118

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Anxiety; Behavior, Animal; Cricetinae; Depression; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mesocricetus; Microinjections; Receptors, AMPA; RNA, Messenger; Stress, Physiological

2014
GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:9

    Topics: Action Potentials; Animals; Biophysics; Calcium; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Functional Laterality; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Oxygen Consumption; Partial Pressure; Pyridines; Receptors, GABA-A; Somatosensory Cortex; Sulfonamides; Thiazoles; Vibrissae; Zolpidem

2015
Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala.
    Frontiers in neural circuits, 2014, Volume: 8

    Topics: Amygdala; Animals; Desoxycorticosterone; Diazepam; GABA Modulators; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Mice; Neural Inhibition; Receptors, GABA-A

2014
Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABAA receptors.
    Psychopharmacology, 2014, Volume: 231, Issue:17

    Topics: Amino Acid Sequence; Cell Polarity; DNA, Complementary; GABA Agonists; HEK293 Cells; Humans; Isoxazoles; Molecular Sequence Data; Mutant Chimeric Proteins; Neurotransmitter Agents; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Transfection

2014
Contributions of the hippocampus and entorhinal cortex to rapid visuomotor learning in rhesus monkeys.
    Hippocampus, 2014, Volume: 24, Issue:9

    Topics: Animals; Association Learning; Entorhinal Cortex; GABA-A Receptor Agonists; Hippocampus; Isoxazoles; Macaca mulatta; Magnetic Resonance Imaging; Male; Memory; Neuropsychological Tests; Psychomotor Performance; Thinking; Time Factors; Visual Perception

2014
Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol.
    Neuroscience, 2014, Jul-11, Volume: 272

    Topics: Animals; Behavior, Animal; Ethanol; Extinction, Psychological; GABA Agonists; Isoxazoles; Male; Mice, Inbred C57BL; Pregnanolone; Receptors, GABA-A

2014
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala.
    Journal of neurophysiology, 2014, Aug-15, Volume: 112, Issue:4

    Topics: Amygdala; Animals; Excitatory Postsynaptic Potentials; Feedback, Physiological; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Phthalazines; Protein Subunits; Pyridazines; Receptors, GABA-A; Synapses; Triazoles

2014
Extrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning.
    Molecular brain, 2014, May-29, Volume: 7

    Topics: Animals; Extinction, Psychological; Fear; Integrases; Isoxazoles; Male; Mediodorsal Thalamic Nucleus; Mice; Mice, Knockout; Pyridazines; Receptors, GABA-A; Synapses; Transfection

2014
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:10

    Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neurons; Seizures; Synapsins

2015
Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice.
    Behavioural brain research, 2014, Oct-15, Volume: 273

    Topics: Alcohol Drinking; Animals; Ethanol; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microinjections; Motor Activity; Prefrontal Cortex; Receptors, GABA-A

2014
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
    Neuroscience bulletin, 2014, Volume: 30, Issue:5

    Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Membrane Potentials; Neurons; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures

2014
Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.
    Psychopharmacology, 2015, Volume: 232, Issue:8

    Topics: Alcohol Drinking; Animals; Ethanol; GABA-A Receptor Agonists; Infusions, Intraventricular; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Pregnanolone; Receptors, GABA-A; Treatment Outcome

2015
Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.
    European journal of pharmacology, 2015, Feb-05, Volume: 748

    Topics: Anesthetics, General; Cell Line, Tumor; Diazepam; Drug Synergism; Electrophysiological Phenomena; Etomidate; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Ion Channel Gating; Isoxazoles; Propofol; Protein Subunits; Protein Transport; Receptors, GABA-A

2015
Paradoxical widespread c-Fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) α6 subunit.
    Neuroscience, 2015, May-07, Volume: 293

    Topics: Animals; Anti-Anxiety Agents; Female; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Prosencephalon; Protein Subunits; Proto-Oncogene Proteins c-fos; Radionuclide Imaging; Receptors, GABA-A

2015
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
    Neurobiology of disease, 2015, Volume: 77

    Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Muscarinic Agonists; Neurons; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Valine

2015
Sleep restores behavioral plasticity to Drosophila mutants.
    Current biology : CB, 2015, May-18, Volume: 25, Issue:10

    Topics: Adenylyl Cyclases; Alzheimer Disease; Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Fatty Acid-Binding Proteins; Female; Isoxazoles; Male; Memory, Long-Term; Memory, Short-Term; Mutation; Organophosphorus Compounds; Receptors, GABA; Reserpine; Sleep

2015
Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING.
    The Journal of biological chemistry, 2015, Jul-24, Volume: 290, Issue:30

    Topics: Animals; Bicuculline; GABA Agonists; GABAergic Neurons; Humans; Isoxazoles; Locus Coeruleus; Methyl-CpG-Binding Protein 2; Mice; Mice, Transgenic; Receptors, GABA; Receptors, GABA-A; Respiration; Rett Syndrome; Single-Cell Analysis; Synapses

2015
Diabetes induces GABA receptor plasticity in murine vagal motor neurons.
    Journal of neurophysiology, 2015, Volume: 114, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Immunohistochemistry; Isoxazoles; Male; Membrane Potentials; Mice; Motor Neurons; Muscimol; Neuronal Plasticity; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Synapses; Vagus Nerve

2015
Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.
    Cell, 2015, Jun-18, Volume: 161, Issue:7

    Topics: Animals; Arousal; Behavior, Animal; Dopamine; Drosophila melanogaster; GABA Agonists; Isoxazoles; Learning; Memory; Models, Animal; Neuronal Plasticity; Neurons; Sleep

2015
GABAergic mechanisms regulated by miR-33 encode state-dependent fear.
    Nature neuroscience, 2015, Volume: 18, Issue:9

    Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; GABA Agonists; GABAergic Neurons; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Organ Culture Techniques; Receptors, GABA-A

2015
Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:2

    Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dogs; Drug Liberation; Humans; Intestinal Absorption; Isoxazoles; Male; Pharmacokinetics; Solubility; Swine; Swine, Miniature

2016
Regulation of Extrasynaptic GABAA α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 356, Issue:1

    Topics: Animals; Bicuculline; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Activators; Ethanol; Female; GABA Antagonists; Isoxazoles; Male; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses

2016
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.
    Brain research bulletin, 2016, Volume: 120

    Topics: Botulinum Toxins, Type A; Cell Membrane; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Dynamins; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrazones; Immunohistochemistry; Isoxazoles; Leupeptins; Membrane Potentials; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Transfection

2016
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Jan-20, Volume: 82

    Topics: Aminolevulinic Acid; Animals; beta-Alanine; Caco-2 Cells; Cell Line; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kidney; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Osmolar Concentration; Osmosis; Proline; Rats; RNA, Messenger; Swine; Taurine; Vigabatrin

2016
Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Dec-09, Volume: 35, Issue:49

    Topics: Action Potentials; Animals; Dentate Gyrus; GABA Agonists; GABA Antagonists; Gene Expression Regulation; Genetic Vectors; Humans; Isoxazoles; Male; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Neurons; Pentylenetetrazole; Protein Subunits; Pyrimidines; Receptors, GABA-A; Somatostatin

2015
Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
    Experimental neurology, 2016, Volume: 277

    Topics: Anesthetics; Animals; Brain Injuries; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Electric Stimulation; Functional Laterality; GABA Agonists; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Neurons; Receptors, GABA-A; RNA, Messenger; Signal Transduction

2016
Involvement of the GABAA Receptor in Age-Dependent Differences in Binge-Like Ethanol Intake.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:2

    Topics: Age Factors; Animals; Binge Drinking; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Receptors, GABA-A

2016
Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats.
    Psychopharmacology, 2016, Volume: 233, Issue:10

    Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Agonists; GABA Modulators; Isoxazoles; Male; Midazolam; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A

2016
Effects of gaboxadol on the expression of cocaine sensitization in rats.
    Experimental and clinical psychopharmacology, 2016, Volume: 24, Issue:2

    Topics: Animals; Central Nervous System Sensitization; Cocaine; Dose-Response Relationship, Drug; Female; GABA Agonists; Injections, Subcutaneous; Isoxazoles; Locomotion; Male; Microinjections; Nucleus Accumbens; Rats; Receptors, GABA-A; Stereotyped Behavior

2016
Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.
    Experimental neurology, 2016, Volume: 280

    Topics: Anesthetics; Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Functional Laterality; GABA Agents; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Immunosuppressive Agents; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors

2016
A pharmacological characterization of GABA, THIP and DS2 at binary α4β3 and β3δ receptors: GABA activates β3δ receptors via the β3(+)δ(-) interface.
    Brain research, 2016, 08-01, Volume: 1644

    Topics: Animals; Benzamides; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Subunits; Receptors, GABA-A; Xenopus laevis

2016
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.
    Scientific reports, 2016, 08-26, Volume: 6

    Topics: Age Factors; Animals; Benzamides; CA1 Region, Hippocampal; Cations, Monovalent; Evoked Potentials; Female; GABA-A Receptor Agonists; Imidazoles; In Vitro Techniques; Isoxazoles; Mice, Inbred C57BL; Models, Neurological; Potassium; Receptors, GABA-A; Seizures; Sexual Maturation

2016
Pharmacologically Counteracting a Phenotypic Difference in Cerebellar GABAA Receptor Response to Alcohol Prevents Excessive Alcohol Consumption in a High Alcohol-Consuming Rodent Genotype.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 08-31, Volume: 36, Issue:35

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; Genotype; In Vitro Techniques; Isoxazoles; Kynurenic Acid; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Patch-Clamp Techniques; Pyridazines; Receptors, GABA-A; Species Specificity; Sucrose

2016
Effects of chronic exposure to low dose THIP on brainstem neuronal excitability in mouse models of Rett syndrome: Evidence from symptomatic females.
    Neuropharmacology, 2017, Volume: 116

    Topics: Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Isoxazoles; Membrane Potentials; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Random Allocation; Rett Syndrome; Tissue Culture Techniques

2017
Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice.
    Human molecular genetics, 2017, 03-15, Volume: 26, Issue:6

    Topics: Animals; Brain; Cognition; Disease Models, Animal; Dystrophin; Fear; GABAergic Neurons; Humans; Isoxazoles; Mice; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Receptors, GABA-A; Stress, Psychological

2017
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
    Scientific reports, 2017, 02-02, Volume: 7

    Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Knockout Techniques; Hyperalgesia; Inflammation; Isoxazoles; Male; Muscimol; Optogenetics; Patch-Clamp Techniques; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission; Thalamus

2017
α4βδ GABA
    Neuroscience, 2017, 04-07, Volume: 347

    Topics: Aging; Animals; CA1 Region, Hippocampal; Dendritic Spines; Female; GABA-A Receptor Agonists; Isoxazoles; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Pregnanolone; Receptors, GABA-A; Spatial Learning

2017
Perinatal high fat diet increases inhibition of dorsal motor nucleus of the vagus neurons regulating gastric functions.
    Neurogastroenterology and motility, 2018, Volume: 30, Issue:1

    Topics: Animals; Bicuculline; Brain Stem; Diet, High-Fat; GABA Agonists; GABA Antagonists; Gastrointestinal Motility; Isoxazoles; Male; Neural Inhibition; Neurons; Pyridazines; Rats, Sprague-Dawley; Vagus Nerve

2018
Interaction between central GABAA receptor and dopaminergic system on food intake in neonatal chicks: role of D
    The International journal of neuroscience, 2018, Volume: 128, Issue:4

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Animals, Newborn; Benzazepines; Chickens; Dopamine; Dopamine Agents; Eating; Female; Food Deprivation; GABA Agents; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Levodopa; Oxidopamine; Receptors, Dopamine D1; Receptors, GABA-A

2018
Oscillatory brain activity in spontaneous and induced sleep stages in flies.
    Nature communications, 2017, 11-28, Volume: 8, Issue:1

    Topics: Animals; Brain; Diptera; Drosophila melanogaster; Electrophysiology; Female; Isoxazoles; Nervous System Physiological Phenomena; Neurons; Sleep; Sleep Stages; Time Factors

2017
Enhanced Activities of δ Subunit-containing GABA
    Neuroscience, 2018, 02-10, Volume: 371

    Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; GABA-A Receptor Agonists; Isoxazoles; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; Pain; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord; Synapses

2018
Modulation of the zebrafish optokinetic reflex by pharmacologic agents targeting GABA
    Neuroscience letters, 2018, 04-03, Volume: 671

    Topics: Animals; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoxazoles; Nystagmus, Optokinetic; Photic Stimulation; Picrotoxin; Reflex; Saccades; Zebrafish

2018
Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.
    Autism research : official journal of the International Society for Autism Research, 2019, Volume: 12, Issue:3

    Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Grooming; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Receptor, trkB

2019
Excitatory/inhibitory balance across ontogeny contributes to age-specific behavioral outcomes of ethanol-like challenge in conditioned taste aversion.
    Developmental psychobiology, 2019, Volume: 61, Issue:8

    Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditioning, Classical; Ethanol; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Agonists; Isoxazoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Taste Perception

2019
How well can a large number of polysomnography sleep measures predict subjective sleep quality in insomnia patients?
    Sleep medicine, 2020, Volume: 67

    Topics: Age Factors; Analgesics; Azepines; Female; Humans; Isoxazoles; Male; Middle Aged; Polysomnography; Predictive Value of Tests; Sleep Aids, Pharmaceutical; Sleep Hygiene; Sleep Initiation and Maintenance Disorders; Time Factors; Triazoles

2020
Upcoming market catalysts in Q3 2020.
    Nature reviews. Drug discovery, 2020, Volume: 19, Issue:7

    Topics: Angelman Syndrome; Azo Compounds; Drug Approval; Fatty Acids; Humans; Isoxazoles; Muscular Atrophy, Spinal; Pyrimidines; Triglycerides; United States

2020
Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit.
    Journal of neurophysiology, 2021, 01-01, Volume: 125, Issue:1

    Topics: Animals; Astacoidea; Ethanol; GABA Agonists; GABA-A Receptor Antagonists; GABAergic Neurons; Interneurons; Isoxazoles; Phosphinic Acids; Pyridines; Social Behavior; Synaptic Potentials

2021
High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABA
    Neurobiology of learning and memory, 2021, Volume: 183

    Topics: Amnesia; Animals; Behavior, Animal; Central Nervous System Depressants; Choice Behavior; Conditioning, Classical; Ethanol; Fear; GABA Agonists; Hippocampus; Isoxazoles; Mammillary Bodies; Memory; Memory, Episodic; Mice; MicroRNAs; Neural Inhibition; Neural Pathways; Neurons; Pyramidal Cells; Receptors, GABA-A; RNA, Messenger

2021