Page last updated: 2024-08-21

isoxazoles and cysteine

isoxazoles has been researched along with cysteine in 52 studies

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199010 (19.23)18.7374
1990's19 (36.54)18.2507
2000's16 (30.77)29.6817
2010's7 (13.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ballatori, N; Dutczak, WJ1
Grotyohann, LW; Scaduto, RC1
Brown, PI; Nicoll, DW; Rankin, GO; Shih, HC; Teets, VJ; Yang, DJ1
Israel, Y; Shackel, N; Speisky, H; Varghese, G; Wade, D1
Grotyohann, LW; Martin, LF; Scaduto, RC; Slusser, SO1
Armario, A; Garvey, JS; Hidalgo, J1
Elliott, WL; Jayaram, HN; Lui, MS; Pillwein, K; Plowman, J; Reardon, MA; Weber, G1
Anderson, ME; Bridges, RJ; Meister, A; Underwood, M1
Hirayama, K; Inoue, M; Yasutake, A1
Burk, RF; Hill, KE; Von Hoff, DD1
Mego, JL1
Anders, MW; Elfarra, AA; Jakobson, I1
Meredith, MJ; Williams, GM1
Anders, MW; Lash, LH1
Hayden, P; Stevens, J; Taylor, G1
Griffith, OW; Meister, A1
Bernström, K; Hammarström, S; Orning, L1
Lou, L; Nakamura, J; Straub, K; Wu, J1
Horiba, M; Kohno, S; Nabe, T; Ohata, K; Saeki, Y; Tanpo, T; Yamamura, H1
Harada, T; Hiraishi, H; Ivey, KJ; Mutoh, H; Ota, S; Razandi, M; Sugimoto, T; Terano, A1
Anderson, M; Burt, ME; Harrison, LE; Hochwald, SN; Rose, DM1
Dekker, EE; Johnson, AR1
Li, X; Orwar, O; Revesjö, C; Sandberg, M1
Bustos, P; Cardemil, E; Gajardo, MI; Goldie, H; Gómez, C; Jabalquinto, AM1
Raymond, MN; Robin, P; Rossignol, B1
Beers, K; Bottje, WG; Cawthon, D; Evenson, C; McNew, R; Wang, S1
Dringen, R; Hamprecht, B; Pfeiffer, B1
Li, X; Sandberg, M; Wallin, C; Weber, SG1
Chien, KC; Inoue, M; Kasahara, E; Kashiba, M1
Feelisch, M; Grisham, MB; Hallén, K; Jourd'heuil, D1
Barfuss, DW; Cannon, VT; Zalups, RK1
Dahm, LJ; Jones, DP1
Gaston, B; Gozal, D; Johnson, MA; Lieberman, MW; Lipton, AJ; Macdonald, T1
Bandeira-Melo, C; Hall, JC; Penrose, JF; Weller, PF1
Accatino, L; Arrese, M; Koenig, CS; Pizarro, M; Solís, N1
Hedley, DW; Ruoso, P1
Hultberg, B; Hultberg, M1
Bruno, MK; Cohen, SD; Hill, DW; Horton, RA; Roberts, JC; Stern, ST1
Kawabata, D; Mimori, T1
Amrhein, N; Fitzpatrick, TB; Raschle, T1
Matsuda, T; Ohtsubo, H1
Bewley, CA; Fetterolf, BJ; Gutierrez-Lugo, MT; Metaferia, BB; Moravec, M; Ray, S; Shazad-Ul-Hussan, S; Smith, JA1
Saito, E; Suwa, A; Suzuki, Y; Wakabayashi, T1
Yamanaka, H1
Mimori, T; Yukawa, N1
Coppo, L; Di Giuseppe, D; Di Simplicio, P; Frosali, S; Heo, J; Margaritis, A; Priora, R; Summa, D1
Ichikawa, N; Yamanaka, H1
Horenstein, NA; Papke, RL; Stokes, C; Wang, J1
Barfuss, DW; Wang, Y; Zalups, RK1
Arvidsson, PI; Besidski, Y; Bueters, T; Bylund, J; Macsari, I; Olofsson, S; Petersson, C1
Suzuki, Y1
Brindisi, M; Ghosh, AK; Ghosh, K; Huang, X; Kumaragurubaran, N; Lendy, EK; Mesecar, AD; Tang, J; Yen, YC1

Reviews

6 review(s) available for isoxazoles and cysteine

ArticleYear
[Disease modifying anti-rheumatic drugs (DMARDs): an overview].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benzopyrans; Cysteine; Evidence-Based Medicine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Meta-Analysis as Topic; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Sulfonamides

2005
[Effective combination therapy of TNF antagonists with DMARDs].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:7

    Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cysteine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Tumor Necrosis Factor-alpha

2007
[Adverse effects of conventional DMARDs and biologic DMARDs].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug Eruptions; Drug Hypersensitivity; Hematologic Diseases; Humans; Immune System Diseases; Infliximab; Isoxazoles; Kidney Diseases; Leflunomide; Lung Diseases; Methotrexate

2007
[Antirheumatic agents for treatment of rheumatoid arthritis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2008, Oct-10, Volume: 97, Issue:10

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Pharmacogenetics; Randomized Controlled Trials as Topic; Remission Induction; Sulfasalazine; Time Factors

2008
[Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis].
    Clinical calcium, 2009, Volume: 19, Issue:3

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Disease Progression; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Penicillamine; Radiography; Randomized Controlled Trials as Topic; Sulfasalazine; Tacrolimus

2009
[ Bone and cartilage destruction in RA and its intervention. Disease-modifying antirheumatic drugs].
    Clinical calcium, 2012, Volume: 22, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Cartilage; Clinical Trials as Topic; Cysteine; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Sulfasalazine; Tacrolimus

2012

Other Studies

46 other study(ies) available for isoxazoles and cysteine

ArticleYear
gamma-Glutamyltransferase-dependent biliary-hepatic recycling of methyl mercury in the guinea pig.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:2

    Topics: Animals; Bile; Cysteine; gamma-Glutamyltransferase; Glutathione; Guinea Pigs; Isoxazoles; Liver; Male; Methylmercury Compounds

1992
Cysteine oxidation by the postischemic rat kidney.
    The American journal of physiology, 1992, Volume: 262, Issue:5 Pt 2

    Topics: Animals; Cysteine; Glutathione; Iron; Ischemia; Isoxazoles; Kidney; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Renal Circulation

1992
N-(3,5-dichlorophenyl)succinimide nephrotoxicity: evidence against the formation of nephrotoxic glutathione or cysteine conjugates.
    Toxicology, 1991, Volume: 68, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Biotransformation; Cysteine; Fungicides, Industrial; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney Diseases; Male; Rats; Rats, Inbred F344; Succinimides

1991
Role of hepatic gamma-glutamyltransferase in the degradation of circulating glutathione: studies in the intact guinea pig perfused liver.
    Hepatology (Baltimore, Md.), 1990, Volume: 11, Issue:5

    Topics: Animals; Borates; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Guinea Pigs; Isoxazoles; Liver; Perfusion; Serine

1990
Glutathione catabolism by the ischemic rat kidney.
    The American journal of physiology, 1990, Volume: 258, Issue:6

    Topics: Acetylcysteine; Animals; Antimetabolites; Cysteine; gamma-Glutamyltransferase; Glutathione; Ischemia; Isoxazoles; Kidney; Male; Rats; Reperfusion; Sulfhydryl Compounds

1990
On the metallothionein, glutathione and cysteine relationship in rat liver.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Animals; Body Weight; Buthionine Sulfoximine; Cysteine; Glutathione; Isoxazoles; Liver; Male; Metallothionein; Methionine Sulfoximine; Organ Size; Rats; Rats, Inbred Strains; Starvation; Stress, Physiological; Zinc

1990
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
    Cancer chemotherapy and pharmacology, 1990, Volume: 26, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbamates; Cattle; Cysteine; Drug Screening Assays, Antitumor; Glutamates; Glutamine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Rats

1990
Glutathione metabolism at the blood-cerebrospinal fluid barrier.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:13

    Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines

1989
Mechanism of urinary excretion of methylmercury in mice.
    Archives of toxicology, 1989, Volume: 63, Issue:6

    Topics: Animals; Antimetabolites; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methylmercury Compounds; Mice; Mice, Inbred C57BL

1989
Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 (acivicin) on glutathione and cysteine levels in rat brain and plasma.
    Investigational new drugs, 1985, Volume: 3, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Brain; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains

1985
Stimulation of intralysosomal proteolysis by cysteinyl-glycine, a product of the action of gamma-glutamyl transpeptidase on glutathione.
    Biochimica et biophysica acta, 1985, Aug-16, Volume: 841, Issue:2

    Topics: Animals; Borates; Cysteine; Dipeptides; Enzyme Activation; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Liver; Lysosomes; Mice; Peptide Hydrolases; Rats; Serine

1985
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.
    Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2

    Topics: Aminooxyacetic Acid; Animals; Blood Urea Nitrogen; Carbon-Sulfur Lyases; Cysteine; gamma-Glutamyltransferase; Glutathione; Glycosuria; Isoxazoles; Kidney; Liver; Lyases; Male; Mitochondria; Probenecid; Rats; Rats, Inbred F344; Subcellular Fractions

1986
Intracellular glutathione cycling by gamma-glutamyl transpeptidase in tumorigenic and nontumorigenic cultured rat liver cells.
    The Journal of biological chemistry, 1986, Apr-15, Volume: 261, Issue:11

    Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cysteine; Cystine; gamma-Glutamyltransferase; Glutathione; Half-Life; Isoxazoles; Kinetics; Liver; Liver Neoplasms, Experimental; Rats

1986
Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.
    The Journal of biological chemistry, 1986, Oct-05, Volume: 261, Issue:28

    Topics: Adenine Nucleotides; Aminooxyacetic Acid; Aminopeptidases; Animals; CD13 Antigens; Cell Survival; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Glutathione; Glycylglycine; Isoxazoles; Kidney Tubules, Proximal; Male; Oxygen Consumption; Phenanthrolines; Rats; Rats, Inbred F344; Time Factors

1986
The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells.
    The Journal of biological chemistry, 1986, Mar-05, Volume: 261, Issue:7

    Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Carbon-Sulfur Lyases; Cell Line; Cell Survival; Cysteine; Glutathione; Isoxazoles; Kidney Tubules, Proximal; Lyases; Microscopy, Electron; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Swine

1986
Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:6

    Topics: Animals; Autoanalysis; Biological Transport; Cysteine; Dipeptides; Disulfides; gamma-Glutamyltransferase; Glutamates; Glutathione; Glutathione Reductase; Glycine; Humans; Isoxazoles; Male; Mice

1980
Formation of leukotrienes E3, E4 and E5 in rat basophilic leukemia cells.
    European journal of biochemistry, 1981, Volume: 120, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Calcimycin; Chromatography, High Pressure Liquid; Cysteine; Glycine; Isoxazoles; Leukemia, Experimental; Leukotriene E4; Rats; SRS-A

1981
The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine.
    The Journal of biological chemistry, 1995, Oct-06, Volume: 270, Issue:40

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Carbon-Nitrogen Ligases; Cysteine; Enzyme Inhibitors; Glutamine; Guanosine Monophosphate; Humans; Hydrolysis; In Vitro Techniques; Isoxazoles; Kinetics; Ligases; Molecular Sequence Data; Peptide Fragments

1995
Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:3

    Topics: Cell Membrane; Chromones; Cysteine; gamma-Glutamyltransferase; Glycine; Humans; Isoxazoles; Leukotriene D4; Lung; Protein Binding; SRS-A

1994
Protection of cultured rat gastric cells against oxidant-induced damage by exogenous glutathione.
    Gastroenterology, 1994, Volume: 106, Issue:5

    Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Chromium Radioisotopes; Cysteine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Glucose; Glucose Oxidase; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; Isoxazoles; Male; Methionine Sulfoximine; Protein Precursors; Rats; Rats, Sprague-Dawley; Resting Phase, Cell Cycle; Stomach

1994
gamma-Glutamyl transpeptidase mediation of tumor glutathione utilization in vivo.
    Journal of the National Cancer Institute, 1996, Feb-21, Volume: 88, Issue:3-4

    Topics: Animals; Cysteine; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Methylcholanthrene; Rats; Rats, Inbred F344; Sarcoma, Experimental

1996
Woodward's reagent K inactivation of Escherichia coli L-threonine dehydrogenase: increased absorbance at 340-350 nm is due to modification of cysteine and histidine residues, not aspartate or glutamate carboxyl groups.
    Protein science : a publication of the Protein Society, 1996, Volume: 5, Issue:2

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Cysteine; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Histidine; Isoxazoles; Kinetics; Models, Chemical; Molecular Sequence Data; Solvents; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds

1996
Gamma-glutamyl peptides and related amino acids in rat hippocampus in vitro: effect of depolarization and gamma-glutamyl transpeptidase inhibition.
    Neurochemistry international, 1996, Volume: 29, Issue:2

    Topics: Amino Acids; Animals; Aspartic Acid; Cysteine; Dipeptides; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutamine; Glutathione; Hippocampus; Isoxazoles; Male; Rats; Rats, Sprague-Dawley

1996
Woodward's reagent K reacts with histidine and cysteine residues in Escherichia coli and Saccharomyces cerevisiae phosphoenolpyruvate carboxykinases.
    Journal of protein chemistry, 1996, Volume: 15, Issue:5

    Topics: Amino Acids; Binding Sites; Cysteine; Escherichia coli; Histidine; Indicators and Reagents; Isoxazoles; Kinetics; Phosphoenolpyruvate Carboxykinase (GTP); Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet

1996
Detoxification mechanism in the rat extraorbital lacrimal gland: conjugation of brefeldin A to glutathione.
    Experimental eye research, 1997, Volume: 64, Issue:6

    Topics: Animals; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Cysteine; Enzyme Inhibitors; Glutathione; Inactivation, Metabolic; Isoxazoles; Lacrimal Apparatus; Male; Rats; Rats, Sprague-Dawley

1997
Hepatic export of glutathione and uptake of constituent amino acids, glutamate and cysteine, in broilers in vivo.
    Poultry science, 1998, Volume: 77, Issue:10

    Topics: Animals; Biological Transport; Carotid Arteries; Chickens; Cysteine; Cystine; Dipeptides; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamic Acid; Glutathione; Hepatic Veins; Isoxazoles; Liver; Male; Portal Vein

1998
Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Jan-15, Volume: 19, Issue:2

    Topics: Animals; Antioxidants; Astrocytes; Cell Survival; Cells, Cultured; Coculture Techniques; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutamine; Glutathione; Glycine; Isoxazoles; Neurons; Rats; Rats, Wistar

1999
Net efflux of cysteine, glutathione and related metabolites from rat hippocampal slices during oxygen/glucose deprivation: dependence on gamma-glutamyl transpeptidase.
    Brain research, 1999, Jan-02, Volume: 815, Issue:1

    Topics: Animals; Brain Chemistry; Cell Hypoxia; Cysteine; Enzyme Inhibitors; Extracellular Space; Female; gamma-Glutamyltransferase; Glucose; Glutathione; Hippocampus; Isoxazoles; Male; Organ Culture Techniques; Oxygen; Rats; Rats, Sprague-Dawley

1999
Fates and vascular action of S-nitrosoglutathione and related compounds in the circulation.
    Archives of biochemistry and biophysics, 1999, Mar-15, Volume: 363, Issue:2

    Topics: Acetylcysteine; Animals; Blood Pressure; Cysteine; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Nitric Oxide; Nitroso Compounds; Rats; Rats, Wistar; S-Nitrosoglutathione; S-Nitrosothiols

1999
Dynamic state of S-nitrosothiols in human plasma and whole blood.
    Free radical biology & medicine, 2000, Feb-01, Volume: 28, Issue:3

    Topics: Allopurinol; Biotransformation; Chelating Agents; Chlorides; Chromatography, High Pressure Liquid; Cysteine; Enzyme Inhibitors; Glutathione; Humans; Isoxazoles; Mercaptoethanol; Nitroso Compounds; Plasma; S-Nitrosoglutathione; S-Nitrosothiols; Serum Albumin; Zinc Compounds

2000
Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:3

    Topics: Animals; Cilastatin; Cysteine; Dipeptidases; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney Tubules, Proximal; Mercury; Protease Inhibitors; Rabbits; Sequence Homology, Amino Acid

2000
Rat jejunum controls luminal thiol-disulfide redox.
    The Journal of nutrition, 2000, Volume: 130, Issue:11

    Topics: Analysis of Variance; Animals; Cysteine; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Glutathione Disulfide; Isoxazoles; Jejunum; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley

2000
S-nitrosothiols signal the ventilatory response to hypoxia.
    Nature, 2001, Sep-13, Volume: 413, Issue:6852

    Topics: Animals; Cell Hypoxia; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Mice; Nitroso Compounds; Oxygen; Rats; Respiratory Physiological Phenomena; S-Nitrosoglutathione; S-Nitrosothiols; Solitary Nucleus; Sulfhydryl Compounds

2001
Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils.
    The Journal of allergy and clinical immunology, 2002, Volume: 109, Issue:6

    Topics: Acetophenones; Animals; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Eosinophils; Fetal Blood; Humans; Immunohistochemistry; Inflammation Mediators; Interleukin-4; Isoxazoles; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Membrane Proteins; Microscopy, Fluorescence; Pertussis Toxin; Propionates; Quinolines; Rabbits; Receptors, Leukotriene; Tetrazoles; Time Factors; Virulence Factors, Bordetella

2002
Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, Volume: 9, Issue:11

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cysteine; Disease Models, Animal; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Isoxazoles; Liver; Male; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ribosomal Proteins; Saccharomyces cerevisiae Proteins

2003
Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma.
    Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cysteine; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Humans; Isoxazoles; Mice; Mice, SCID; Transplantation, Heterologous; Uterine Cervical Neoplasms

2004
High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 349, Issue:1-2

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cysteine; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; HeLa Cells; Humans; Isoxazoles; Liver Neoplasms; Metals; Sulfhydryl Compounds

2004
Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.
    Toxicology and applied pharmacology, 2005, Jan-15, Volume: 202, Issue:2

    Topics: Acetaminophen; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Injections, Intraperitoneal; Isoxazoles; Kidney Diseases; Kidney Tubules, Proximal; Male; Mass Spectrometry; Mice; Mice, Inbred Strains; Microvilli; Molecular Structure; Toxicity Tests

2005
On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.
    The Journal of biological chemistry, 2005, Sep-16, Volume: 280, Issue:37

    Topics: Antioxidants; Bacillus subtilis; Binding Sites; Carbon-Nitrogen Lyases; Chromatography; Chromatography, Gel; Chromatography, High Pressure Liquid; Cloning, Molecular; Cysteine; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutaminase; Glutamine; Immunochemistry; Isoxazoles; Kinetics; Mass Spectrometry; Models, Chemical; Organophosphates; Oxidoreductases; Pentosephosphates; Protein Structure, Tertiary; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Threonine; Time Factors; Ultraviolet Rays; Vitamin B 6

2005
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase.
    Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25

    Topics: Amidohydrolases; Bacterial Proteins; Binding Sites; Cysteine; Furans; Glycopeptides; Inositol; Isoxazoles; Models, Molecular; Mycobacterium tuberculosis; Oxazines; Oxazoles; Protein Binding; Pyrans; Stereoisomerism; Sulfonamides; Thioglycosides

2007
The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats.
    Toxicology and applied pharmacology, 2010, Feb-01, Volume: 242, Issue:3

    Topics: Animals; Cysteine; Diamide; Enzyme Inhibitors; Erythrocytes; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Liver; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Sulfhydryl Reagents; Time Factors

2010
Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor.
    The Journal of biological chemistry, 2012, Jun-22, Volume: 287, Issue:26

    Topics: Allosteric Site; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Electrophysiology; Humans; Hydrogen Bonding; Isoxazoles; Ligands; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Mutation; Phenylurea Compounds; Protein Conformation; Receptors, Nicotinic

2012
Luminal transport of thiol S-conjugates of methylmercury in isolated perfused rabbit renal proximal tubules.
    Toxicology letters, 2012, Sep-03, Volume: 213, Issue:2

    Topics: Acetylcysteine; Animals; Biological Transport; Cysteine; Female; Glutathione; In Vitro Techniques; Isoxazoles; Kidney Tubules, Proximal; Methylmercury Compounds; Rabbits; Unithiol

2012
Novel bioactivation mechanism of reactive metabolite formation from phenyl methyl-isoxazoles.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:11

    Topics: Carbamates; Carbon; Cysteine; Glutathione; Humans; Isoxazoles; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; NADP; NAV1.1 Voltage-Gated Sodium Channel; Nitrogen; Oxidation-Reduction; Urea; Voltage-Gated Sodium Channel Blockers

2012
[Anti-rheumatic drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 6

    Topics: Antirheumatic Agents; Cysteine; Hematologic Diseases; Humans; Hypersensitivity; Infections; Isoxazoles; Kidney Diseases; Leflunomide; Liver Neoplasms; Lung Diseases; Methotrexate

2012
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
    Bioorganic & medicinal chemistry letters, 2018, 08-15, Volume: 28, Issue:15

    Topics: Alanine; Amides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Bridged Bicyclo Compounds; Carboxylic Acids; Catalytic Domain; Crystallography, X-Ray; Cysteine; Humans; Isoxazoles; Molecular Structure; Protease Inhibitors

2018