Page last updated: 2024-08-21

isoxazoles and cyclosporine

isoxazoles has been researched along with cyclosporine in 152 studies

Research

Studies (152)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	77 (50.66)	18.2507
2000's	48 (31.58)	29.6817
2010's	26 (17.11)	24.3611
2020's	1 (0.66)	2.80

Authors

Authors	Studies
Chong, A; Foster, P; Jensik, S; McChesney, L; Mital, D; Sankary, H; Shen, J; Short, J; Xiao, F; Yang, J	1
Bartlett, RR; Coupland, SE; Hoffmann, F; Karow, AC; Krause, L; Lehmann, M	1
Achilleos, O; Buckels, JA; Candinas, D; D'Silva, M; Dalgic, A; Lee, SJ; Mayer, AD; McMaster, P	1
Kahan, BD	1
Berry, GJ; Billingham, ME; Gregory, CR; Huang, X; Morris, RE; Rowan, R; Shorthouse, R	1
Heeg, K; Lang, R; Wagner, H	1
Lin, Y; Sobis, H; Vandeputte, M; Waer, M	3
Cao, W; Huang, X; Morris, RE; Shorthouse, RA; Zheng, B	1
Lang, LS; Robertson, SM	1
Chong, AS; Foster, P; Frieders, D; Koukoulis, G; McChesney, L; Sankary, H; Williams, JW; Xiao, F; Yang, J	1
Bitter-Suermann, H; Lee, T; MacAuley, MA; MacDonald, AS; McAlister, VC; Sabr, K	1
Bartlett, RR; Coupland, SE; Hoffmann, F; Karow, AC; Klebe, S; Krause, L; Kruse, H	1
Foster, PF; Haklin, M; McChesney, LP; Sankary, HN; Sharma, S; Williams, JW; Xiao, F	1
Chong, A; Foster, P; Frieders, D; McChesney, L; Sankary, H; Williams, JM; Williams, JW; Xiao, F	1
Kearns, H; McDonald, AS; Wright, JR	1
Bitter-Suermann, H; He, G; Lee, TD; MacDonald, AS; McAlister, VC; Theal, M; Wright, J	1
Lang, LS; Mellon, J; Niederkorn, JY; Robertson, SM; Ross, J	1
Chong, AS; Clardy, C; Foster, P; McChesney, L; Sankary, H; Williams, JW; Xiao, F	1
Connolly, KM; Noel, LS; Smith-Oliver, T; Stimpson, SS; Yarnall, DP	1
Chong, AS; Finnegan, A; Foster, P; Gebel, H; Jiang, X; Sankary, HN; Williams, JW	1
Bartlett, R; Chong, A; Foster, PF; Sankary, HN; Sharma, S; Williams, JW; Xiao, F	1
Chong, AS; Finnegan, A; Foster, P; Gebel, H; Jiang, XL; Petraitis, EE; Sankary, HN; Williams, JW	1
Bartlett, RR; Schorlemmer, HU; Seiler, FR	1
Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Rafael, E; Sundberg, B; Tibell, A; Wallgren, AC; Wennberg, L; Zhu, S	2
Lin, Y; Vandeputte, M; Waer, M	4
Furst, DE	1
Blinder, L; Chong, AS; Foster, P; Sankary, H; Shen, J; Williams, JW; Xiao, F	1
Blinder, HL; Chong, A; Foster, P; Liu, W; McChesney, L; Mital, D; Sankary, H; Shen, J; Williams, JW; Xiao, F	1
Kemp, E; Lillevang, S; Nielsen, B; Salomon, S; Steinbrüchel, DA	1
Adams, B; Berry, GJ; Brazelton, T; Morris, RE; Reichenspurner, H; Reitz, BA; Shorthouse, R; Soni, V	1
Gregory, CR; Griffey, SM; Levitski, RE; Lirtzman, RA; Morris, RE; Patz, JD; Yeh, LS	1
Halloran, PF	1
Blinder, L; Chong, AS; Foster, P; Sankary, H; Shen, J; Wei, L; Williams, J; Xiao, F	1
Coupland, SE; Hoffmann, F; Klebe, S; Krause, L	1
Gregory, CR; Griffey, SM; Lecouteur, RA; Morris, RE; Yeh, LS	1
Brauer, R; Henzgen, S; Katenkamp, D; Petrow, PK; Thoss, K	1
Foster, PF; Kociss, K; Sankary, HN; Shen, J; Williams, JW; Xiao, F	1
Kurrle, R; Schorlemmer, HU	4
Kurrle, R; Ruuth, E; Schorlemmer, HU; Schwab, W	1
Lin, Y; Waer, M	2
Chong, AS; Foster, P; Gebel, H; Guo, Z; Jensik, SC; McChesney, L; Mital, D; Sankary, HN; Shen, J; Williams, JW	1
Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Rafael, E; Sundberg, B; Wennberg, L; Zhu, S	1
d'Atri, G; Di Pierro, F; Leoni, F; Marcucci, F	1
Chong, AS; Foster, P; Guo, Z; Jensik, S; McChesney, L; Mital, D; Sankary, H; Shen, J; Tian, Y; Williams, JW; Yin, D	1
Chong, AS; Foster, PF; Fu, Z; Guo, Z; Jensik, S; McChesney, LP; Mital, D; Sankary, HN; Shen, J; Tian, Y; Williams, JW	1
Biberfeld, P; Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Morris, RE; Rafael, E; Söderlund, J; Tibell, A; Wennberg, L; Zhu, S	1
Blinder, L; Chong, AS; Foster, P; Karademir, S; Sankary, H; Shen, J; Short, J; Williams, JW	1
Gregory, CR; Griffey, SM; Hou, SM; Lecouter, RA; Morris, RE; Yeh, LS	1
Blinder, L; Chong, AS; Ma, LL; Shen, J; Williams, JW; Yin, DP	1
Ji, P; Lin, Y; Vandeputte, M; Waer, M; Xia, G	1
Ekberg, H; Hedlund, G; Ostraat, O; Qi, ZQ; Tufveson, G	1
Gregory, CR	1
Kitada, M; Kiuchi, M; Nakamura, H; Nakasa, H; Ohmori, S; Ono, S; Tsutsui, M	1
Bonham, CA; Gerber, DA; Thomson, AW	1
Horn, HC; Jensen, JE; Johansen, A; Kemp, E; Nielsen, B	1
Lindner, JK; Zantl, N	1
Kurrle, R; Ruuth, E; Schorlemmer, HU	1
Blinder, L; Chong, AS; Ma, LL; Sankary, H; Shen, J; Williams, JW; Yin, D	1
Blinder, L; Chong, AS; Foster, P; Huang, W; Jensik, S; Liu, W; McChesney, L; Mital, D; Sankary, H; Shen, J; Williams, JW; Xiao, F	1
Ekberg, H; Qi, Z; Simanaitis, M	1
Ekberg, H; Qi, Z	1
Gregory, CR; Hou, SM; Jeng, CR; Lai, YC; Lui, LT; Yeh, LS	1
Dimitrijevic, M; Glisic, B; Obradovic, S; Pejnovic, N; Popovic, M; Popovic, R; Stefanovic, D	1
Gross, WL	1
Berry, GJ; Boeke, K; Christians, U; Gummert, JF; Hausen, B; Morris, RE	1
Morris, RE; Sherwood, SW; Silva, HT; Slauson, SD	1
Bari, S; Groth, CG; Korsgren, O; Song, Z; Sundberg, B; Wennberg, L; Wijkström, M; Zhang, J	1
Bari, S; Bennet, W; Groth, CG; Korsgren, O; Nava, S; Song, Z; Sundberg, B; Wennberg, L; Zhang, J	2
Craigmill, AL; Gregory, CR; Kyles, AE	1
Dambrin, C; Klupp, J; Morris, RE	1
Ambach, A; Konstandin, M; Meuer, SC; Samstag, Y; Saunus, J; Wesselborg, S	1
Achilleos, O; Candinas, D; D'Silva, M; Dalgic, A; Lee, SJ; Mayer, AD; McMaster, P; Miki, C	1
Kremer, JM	1
Bouillon, R; Gysemans, C; Laureys, J; Mathieu, C; Waer, M	1
duToit, DF; Lyners, R; Mattysen, J; Muller, CJ; Muller, N; Page, BJ	1
Albert, R; Andersen, E; Floersheim, P; Hungerford, V; Papageorgiou, C; Schreier, MH; Zurini, M	1
O'Dell, J	1
Remer, CF; Wallace, DJ; Weisman, MH	1
Bickerstaff, A; Gordillo, G; Knight, DA; Orosz, CG; Orosz, K; Waldman, WJ	1
Pisetsky, DS; St Clair, EW	1
Flores, RH; Hochberg, MC; Tracy, JK	1
Drosos, AA	1
Fujita, M; Furukawa, H; Jin, MB; Mino, K; Nakayama, M; Ogata, T; Shimamura, T; Suzuki, T; Taniguchi, M; Todo, S	1
Groth, CG; Hagberg, A; Korsgren, O; Krook, H; Song, Z; Wennberg, L	1
Gross, WL; Schnabel, A	1
Bernsteen, L; Gregory, CR; Griffey, SM; Kyles, AE; Lilja, HS; Morris, RE; Pierce, J	1
Balabanova, RM	1
Billingham, M; Brazelton, T; Briffa, NP; Chan, J; Morris, RE; Shorthouse, R; Silva, H	1
Burmester, GR; Müller-Ladner, U; Rüther, W	1
Emery, P; Suarez-Almazor, M	1
Gladman, DD	1
Heath, M; Raugi, GJ	1
Assimakopoulos, D; Bai, M; Drosos, AA; Papazisi, D; Voulgari, PV; Zagorianakou, P	1
Fath, R	1
Burmester, GR	1
Casadio, F; Corti, B; Croci, S; D'Errico Grigioni, A; Grigioni, WF; Landuzzi, L; Lollini, PL	1
Ejsing, TB; Linnet, K; Pedersen, AD	1
Andrianakos, A; Antoniades, C; Charalambopoulos, D; Karanikolas, G; Katsilambros, N	1
Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E	3
Badgwell, C; Rosen, T	1
Saito, E; Suwa, A; Suzuki, Y; Wakabayashi, T	1
Tłustochowicz, W	1
McHugh, NJ; Soriano, ER	1
Deuse, T; Hoyt, G; Koyanagi, T; Robbins, RC; Schrepfer, S	1
Bagot, M; Claudepierre, P	1
Andrianakos, A; Charalambopoulos, D; Karanikolas, G; Karras, D; Kaskani, E; Rapti, A; Sfikakis, PP; Vaiopoulos, G	1
Gergely, P; Poór, G	1
Mimori, T; Yukawa, N	1
Mimori, T	1
Chen, X; Huang, P; Luo, S; Tu, G; Yang, G; Yao, Z	1
Förger, F; Østensen, M	1
Andrade, RJ; Cotta, J; Lucena, MA; Robles, M; Toscano, E	1
Dickenmann, M; Egli, A; Hirsch, HH; Köhli, S	1
Bonsmann, G; Kuhn, A; Ruland, V	1
First, MR; Fitzsimmons, W; Guasch, A; Holman, J; Roy-Chaudhury, P; Woodle, ES	1
Matuszewska, A; Misterska-Skóra, M; Wiland, P	1
Mishra, OP; Mittal, R; Prasad, R; Singh, UK	1
Kiss, CG; Kiss, E; Poór, G	1
Gao, E; He, B; Koch, W; Lau, WB; Ma, XL; Pu, J; Shan, P; Wang, X; Wang, Y; Yuan, A	1
Lei, T; Liu, G; Peng, J; Sun, C; Wang, R; Wu, T; Xu, K; Zhang, L; Zhao, Y	1
Lubrano, E; Scarpa, R	1
Miller, AV; Ranatunga, SK	1
Allahyari, M; Farimani, ES; Hadizadeh, F; Moalem, SA; Rameshrad, M	1
Chen, D; Hu, X; Li, L; Ma, Y; Mao, Z; Mei, C; Sun, L; Xie, G; Xu, C; Xu, J; Yang, L; Ye, C; Zhao, X	1
Dodam, JR; Nafe, LA; Reinero, CR	1
Batat, E; Bitterman, H; Cohen, AD; Cohen, S; Comanesther, D; Feldhamer, I; Greenberg-Dotan, S; Shalom, G; Zisman, D	1
Foley, P; Kelly, JB; Strober, BE	1
Chan, TM	1
López-González, R; Martín-Martínez, MA; Pérez-Vicente, S; Silva-Fernández, L	1
Frambach, Y; Gerdes, S; Jacobi, A; Mössner, R; Philipp, S; Weyergraf, AJ; Wilsmann-Theis, D	1
Bitterman, H; Cohen, AD; Cohen, Y; Dreiher, J; Feldhamer, I; Greenberg-Dotan, S; Hammerman, A; Harman-Boehm, I; Moser, H; Shalom, G; Zisman, D	1
Moroni, G; Ponticelli, C	1
Chen, CJ; Cheng, TT; Lin, JC; Lin, KM	1
Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D	1
Forte, M; Šileikytė, J	1
Craig, JC; Hodson, EM; Willis, NS; Wong, SC	1
Al Habeeb, A; Chan, AW; Chang, J; Kassar, R; Lilly, LB; Rotstein, C	1
Archer, TM; Mackin, AJ; Thomason, JM; Wills, RW	1
Kowdley, KV; Shah, RA	1

Reviews

37 review(s) available for isoxazoles and cyclosporine

Article	Year
New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. Therapeutic immunology, 1994, Volume: 1, Issue:1 Topics: Animals; Antimetabolites; Azathioprine; Biphenyl Compounds; Cell Differentiation; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Lymphokines; Oligonucleotides, Antisense; Polyenes; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; Tacrolimus	1994
Innovative treatment approaches for rheumatoid arthritis. Cyclosporin, leflunomide and nitrogen mustard. Bailliere's clinical rheumatology, 1995, Volume: 9, Issue:4 Topics: Absorption; Alkylating Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Mechlorethamine; Tissue Distribution	1995
Molecular mechanisms of new immunosuppressants. Clinical transplantation, 1996, Volume: 10, Issue:1 Pt 2 Topics: Amino Acid Isomerases; B-Lymphocytes; Biphenyl Compounds; Calcineurin; Calmodulin-Binding Proteins; Carrier Proteins; Cyclosporine; Enzyme Inhibitors; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Isoxazoles; Leflunomide; Mycophenolic Acid; Oxidoreductases; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Polyenes; Purines; Pyrimidines; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus	1996
Immunosuppressive approaches to the prevention of graft vascular disease. Transplantation proceedings, 1998, Volume: 30, Issue:3 Topics: Coronary Disease; Cyclosporine; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Polyenes; Postoperative Complications; Sirolimus; Tacrolimus	1998
Immunosuppressive agents: recent developments in molecular action and clinical application. Transplantation proceedings, 1998, Volume: 30, Issue:4 Topics: Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Models, Biological; Mycophenolic Acid; Polyenes; Ribonucleosides; Sirolimus; T-Lymphocytes; Tacrolimus; Transplantation Immunology	1998
New concepts in treatment protocols for severe systemic vasculitis. Current opinion in rheumatology, 1999, Volume: 11, Issue:1 Topics: Cyclophosphamide; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Vasculitis	1999
Pharmacodynamics of immunosuppressive drugs. Current opinion in immunology, 2000, Volume: 12, Issue:5 Topics: Animals; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Sirolimus; Tacrolimus	2000
Rational use of new and existing disease-modifying agents in rheumatoid arthritis. Annals of internal medicine, 2001, Apr-17, Volume: 134, Issue:8 Topics: Adjuvants, Immunologic; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Costs; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Risk Factors; Sulfasalazine	2001
Progress in the treatment of rheumatoid arthritis. JAMA, 2001, Dec-12, Volume: 286, Issue:22 Topics: Analgesics; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclosporine; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine	2001
"Stepping-up" from methotrexate: a systematic review of randomised placebo controlled trials in patients with rheumatoid arthritis with an incomplete response to methotrexate. Annals of the rheumatic diseases, 2001, Volume: 60 Suppl 3 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Maximum Tolerated Dose; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome	2001
Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy. Drugs, 2002, Volume: 62, Issue:6 Topics: Animals; Arthritis, Rheumatoid; Cyclosporine; Cytokines; Gene Expression Regulation; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mitogen-Activated Protein Kinases; Mycophenolic Acid; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Sirolimus; Tacrolimus	2002
[Current concepts of pharmacotherapy in rheumatoid arthritis]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:7 Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Cyclophosphamide; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Feasibility Studies; Female; Glucocorticoids; Humans; Ibuprofen; Immunosuppressive Agents; Isoxazoles; Ketoprofen; Leflunomide; Male; Methotrexate; Prednisolone; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Sulfasalazine; Time Factors	2003
[Diagnosis and therapy of rheumatoid arthritis]. Deutsche medizinische Wochenschrift (1946), 2004, Jun-04, Volume: 129, Issue:23 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty; Cyclooxygenase Inhibitors; Cyclosporine; Drug Therapy, Combination; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Methotrexate; Rheumatoid Factor; Sulfasalazine	2004
Rheumatoid arthritis. Clinical evidence, 2003, Issue:9 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine	2003
Psoriatic arthritis. Dermatologic therapy, 2004, Volume: 17, Issue:5 Topics: Adalimumab; Alefacept; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimalarials; Arthritis, Psoriatic; Azathioprine; Cyclosporine; Etanercept; Gold Sodium Thiomalate; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; Sulfasalazine; Tumor Necrosis Factor Decoy Receptors	2004
Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus. Advances in dermatology, 2004, Volume: 20 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Azathioprine; Cladribine; Cyclophosphamide; Cyclosporine; Evidence-Based Medicine; Humans; Immunoglobulin G; Immunologic Factors; Immunotherapy; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; Methotrexate; Mycophenolic Acid; Rituximab; Tacrolimus; Thalidomide	2004
Laryngeal involvement in rheumatoid arthritis. Rheumatology international, 2005, Volume: 25, Issue:5 Topics: Aged; Anti-Inflammatory Agents; Arytenoid Cartilage; Cricoid Cartilage; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Joints; Laryngeal Diseases; Leflunomide; Methylprednisolone; Prednisone; Rheumatoid Nodule; Treatment Outcome	2005
Cutaneous sarcoidosis therapy updated. Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigen Presentation; Antimalarials; Chlorambucil; Contraindications; Cyclosporine; Cytokines; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infliximab; Isoxazoles; Laser Therapy; Leflunomide; Male; Melatonin; Methotrexate; Models, Immunological; Pentoxifylline; Pregnancy; Pregnancy Complications; Sarcoidosis; Skin Diseases; Tetracyclines; Th1 Cells; Thalidomide	2007
[Inhibition of radiographic progression in rheumatoid arthritis by anti-rheumatic drugs (DMARDs)]. Clinical calcium, 2007, Volume: 17, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclosporine; Disease Progression; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Radiography; Remission Induction; Sulfasalazine	2007
[Rational therapeutic approach in rheumatoid arthritis]. Annales Academiae Medicae Stetinensis, 2006, Volume: 52 Suppl 2 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Joint Prosthesis; Leflunomide; Methotrexate; Prostheses and Implants; Sulfasalazine	2006
Conventional therapy of psoriatic arthritis: evidence-based review. Reumatismo, 2007, Volume: 59 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Cyclosporine; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Methotrexate; Mycophenolic Acid; Sulfasalazine; Treatment Outcome	2007
[New ways in the management of rheumatoid arthritis in Hungary]. Lege artis medicinae : uj magyar orvosi hirmondo, 2007, Volume: 17, Issue:10 Topics: Abatacept; Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Azathioprine; Chloroquine; Cyclophosphamide; Cyclosporine; Diagnosis, Differential; Early Diagnosis; Etanercept; Humans; Hungary; Immunoconjugates; Immunoglobulin G; Immunologic Factors; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prognosis; Receptors, Tumor Necrosis Factor; Rituximab; Sulfasalazine; Tumor Necrosis Factor-alpha	2007
[Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis]. Clinical calcium, 2009, Volume: 19, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Disease Progression; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Penicillamine; Radiography; Randomized Controlled Trials as Topic; Sulfasalazine; Tacrolimus	2009
[Immunosuppressants]. Nihon rinsho. Japanese journal of clinical medicine, 2009, Volume: 67, Issue:3 Topics: Azathioprine; Calcineurin Inhibitors; Collagen Diseases; Cyclophosphamide; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Rheumatic Diseases; Ribonucleosides; Risk Assessment; Tacrolimus	2009
Management of RA medications in pregnant patients. Nature reviews. Rheumatology, 2009, Volume: 5, Issue:7 Topics: Abatacept; Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Contraindications; Cyclosporine; Female; Gestational Age; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Rituximab; Sulfasalazine; Young Adult	2009
Cutaneous lupus erythematosus: update of therapeutic options part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:6 Topics: Algorithms; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Clofazimine; Cyclophosphamide; Cyclosporine; Dapsone; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Interferon-alpha; Isoxazoles; Leflunomide; Lenalidomide; Lupus Erythematosus, Cutaneous; Methotrexate; Mycophenolic Acid; Retinoids; Rituximab; Thalidomide; Tumor Necrosis Factor-alpha	2011
Immunosuppressive therapy in children. Journal of the Indian Medical Association, 2011, Volume: 109, Issue:2 Topics: Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Child; Cyclophosphamide; Cyclosporine; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mercaptopurine; Methotrexate; Mycophenolic Acid; Nitriles; Sirolimus; Tacrolimus	2011
[Systemic autoimmune disorders and pregnancy]. Orvosi hetilap, 2011, Oct-23, Volume: 152, Issue:43 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Administration Schedule; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Remission Induction; Sjogren's Syndrome; Sulfasalazine; Teratogens; Tumor Necrosis Factor-alpha	2011
Psoriatic arthritis: treatment strategies using anti-inflammatory drugs and classical DMARDs. Reumatismo, 2012, Jun-05, Volume: 64, Issue:2 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Clinical Trials as Topic; Cyclosporine; Evidence-Based Medicine; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Multicenter Studies as Topic; Nails; Skin; Sulfasalazine	2012
Immunotherapies in rheumatologic disorders. The Medical clinics of North America, 2012, Volume: 96, Issue:3 Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Azathioprine; Certolizumab Pegol; Colchicine; Cyclophosphamide; Cyclosporine; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoconjugates; Immunoglobulin Fab Fragments; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Mycophenolic Acid; Polyethylene Glycols; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Rheumatic Diseases; Rituximab; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2012
Immunosuppressive treatment for nephrotic idiopathic membranous nephropathy: a meta-analysis based on Chinese adults. PloS one, 2012, Volume: 7, Issue:9 Topics: Adult; Alkylating Agents; Calcineurin Inhibitors; China; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Cyclosporine; Female; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Mycophenolic Acid; Remission Induction; Tacrolimus	2012
Current and future oral systemic therapies for psoriasis. Dermatologic clinics, 2015, Volume: 33, Issue:1 Topics: Acitretin; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Cyclosporine; Fumarates; Humans; Hydroxyurea; Immunosuppressive Agents; Isoxazoles; Keratolytic Agents; Leflunomide; Methotrexate; Mycophenolic Acid; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Sulfasalazine; Thalidomide; Thioguanine	2015
Treatment of severe lupus nephritis: the new horizon. Nature reviews. Nephrology, 2015, Volume: 11, Issue:1 Topics: Antimalarials; Azathioprine; Biological Products; Cyclophosphamide; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Nephritis; Mycophenolic Acid; Ribonucleosides; Severity of Illness Index; Sirolimus; Tacrolimus	2015
Immunosuppression in pregnant women with systemic lupus erythematosus. Expert review of clinical immunology, 2015, Volume: 11, Issue:5 Topics: Contraindications; Cyclosporine; Female; Glucocorticoids; Humans; Hypertension; Immunosuppression Therapy; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Maternal Exposure; Mycophenolic Acid; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Withholding Treatment	2015
Shutting down the pore: The search for small molecule inhibitors of the mitochondrial permeability transition. Biochimica et biophysica acta, 2016, Volume: 1857, Issue:8 Topics: Anilides; Benzamidines; Cyclosporine; Drug Design; High-Throughput Screening Assays; Isoxazoles; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Oximes; Peptides, Cyclic; Quinolinium Compounds; Secosteroids; Structure-Activity Relationship	2016
Interventions for idiopathic steroid-resistant nephrotic syndrome in children. The Cochrane database of systematic reviews, 2016, Oct-11, Volume: 10 Topics: Adolescent; Angiotensin-Converting Enzyme Inhibitors; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Cyclosporine; Dexamethasone; Drug Resistance; Glucocorticoids; Humans; Immunosuppressive Agents; Infant; Isoxazoles; Leflunomide; Mycophenolic Acid; Nephrotic Syndrome; Prednisone; Randomized Controlled Trials as Topic; Remission Induction	2016
Current and potential treatments for primary biliary cholangitis. The lancet. Gastroenterology & hepatology, 2020, Volume: 5, Issue:3 Topics: Benzothiazoles; Bezafibrate; Bile Acids and Salts; Budesonide; Case-Control Studies; Chenodeoxycholic Acid; Cholagogues and Choleretics; Clinical Trials as Topic; Cyclosporine; Disease Progression; Glucocorticoids; Homeostasis; Humans; Immunologic Factors; Immunosuppressive Agents; Isoxazoles; Liver Cirrhosis, Biliary; Liver Transplantation; Peroxisome Proliferator-Activated Receptors; Receptors, Cytoplasmic and Nuclear; Rituximab; Treatment Outcome; United States; United States Food and Drug Administration; Ursodeoxycholic Acid	2020

Trials

5 trial(s) available for isoxazoles and cyclosporine

Article	Year
Comparative study of the clinical efficacy of four DMARDs (leflunomide, methotrexate, cyclosporine, and levamisole) in patients with rheumatoid arthritis. Transplantation proceedings, 1998, Volume: 30, Issue:8 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Levamisole; Male; Methotrexate; Middle Aged	1998
Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis. The Journal of rheumatology, 2006, Volume: 33, Issue:3 Topics: Adjuvants, Immunologic; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Isoxazoles; Joints; Leflunomide; Severity of Illness Index; Treatment Outcome	2006
Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate, or leflunomide, or cyclosporin-A monotherapy: a 48-week, comparative, prospective study. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:9 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome	2008
Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy. Transplantation, 2010, Oct-27, Volume: 90, Issue:8 Topics: Algorithms; Alkynes; Creatinine; Cyclosporine; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Mycophenolic Acid; Nitriles; Patient Compliance; Polyomavirus Infections; Sirolimus; Tacrolimus; Time Factors; Viral Load	2010
Effects of immunosuppressive agents on the hemostatic system in normal dogs. Journal of veterinary internal medicine, 2018, Volume: 32, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azathioprine; Blood Coagulation; Blood Platelets; Creatinine; Cross-Over Studies; Cyclosporine; Dogs; Female; Hemostasis; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mycophenolic Acid; Platelet Aggregation; Platelet Count; Prednisone; Thromboxane B2	2018

Other Studies

110 other study(ies) available for isoxazoles and cyclosporine

Article	Year
Pharmacologically induced regression of chronic transplant rejection. Transplantation, 1995, Nov-27, Volume: 60, Issue:10 Topics: Animals; Cell Division; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Leflunomide; Male; Muscle, Smooth; Rats; Rats, Inbred F344; Rats, Inbred Lew	1995
Delay in corneal allograft rejection due to anti-CD4 antibody given alone and in combination with cyclosporin A and leflunomide. German journal of ophthalmology, 1995, Volume: 4, Issue:5 Topics: Animals; Antibodies, Monoclonal; CD4 Antigens; Corneal Transplantation; Cyclosporine; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Rats, Inbred BN; Rats, Inbred Lew; Time Factors; Transplantation, Homologous	1995
Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. Transplantation proceedings, 1994, Volume: 26, Issue:6 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Tacrolimus; Transplantation, Heterotopic; Transplantation, Homologous	1994
Studies in experimental models of chronic rejection: use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogue) for the suppression of graft vascular disease and obliterative bronchiolitis. Transplantation proceedings, 1995, Volume: 27, Issue:3 Topics: Animals; Bronchiolitis Obliterans; Cyclosporine; Graft Occlusion, Vascular; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Polyenes; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tunica Intima	1995
Differential effects of the immunosuppressive agents cyclosporine and leflunomide in vivo. Leflunomide blocks clonal T cell expansion yet allows production of lymphokines and manifestation of T cell-mediated shock. Transplantation, 1995, Feb-15, Volume: 59, Issue:3 Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Cyclosporine; Flow Cytometry; Interleukin-2; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Superantigens; T-Lymphocytes; Tumor Necrosis Factor-alpha	1995
Mechanism of leflunomide-induced prevention of xenoantibody formation and xenograft rejection in the hamster to rat heart transplantation model. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Animals; Antibodies, Heterophile; Antibody Formation; Complement System Proteins; Cricetinae; Cyclosporine; Cytotoxicity, Immunologic; Flow Cytometry; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Strains; Rats, Nude; Transplantation, Heterologous	1995
Leflunomide (HWA 486) and its analog suppress T- and B-cell proliferation in vitro, acute rejection, ongoing rejection, and antidonor antibody synthesis in mouse, rat, and cynomolgus monkey transplant recipients as well as arterial intimal thickening afte Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arteries; B-Lymphocytes; Catheterization; Crotonates; Cyclosporine; Graft Rejection; Graft Survival; Heart Transplantation; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Toluidines; Transplantation, Homologous; Tunica Intima	1995
Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. Agents and actions, 1994, Volume: 42, Issue:3-4 Topics: Administration, Oral; Administration, Topical; Animals; Antibodies; Antigens; Arrestin; Autoimmune Diseases; Cyclosporine; Dexamethasone; Dose-Response Relationship, Drug; Eye Proteins; Freund's Adjuvant; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Retina; Uveitis	1994
Leflunomide controls rejection in hamster to rat cardiac xenografts. Transplantation, 1994, Oct-15, Volume: 58, Issue:7 Topics: Animals; Cricetinae; Cyclosporine; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Lew; Transplantation, Heterologous	1994
Induction therapy of leflunomide and cyclosporine allows for long-term xenograft survival under cyclosporine alone. Transplantation proceedings, 1994, Volume: 26, Issue:5 Topics: Animals; Cricetinae; Cyclosporine; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Time Factors; Transplantation, Heterologous	1994
Long-term xenograft survival and suppression of xenoantibody formation in the hamster-to-rat heart transplant model using a combination therapy of leflunomide and cyclosporine. Transplantation proceedings, 1994, Volume: 26, Issue:6 Topics: Animals; Antibodies, Heterophile; Cricetinae; Cyclosporine; Cytotoxicity, Immunologic; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Strains; Time Factors; Transplantation, Heterologous	1994
Effects of leflunomide and cyclosporine on aortic allograft chronic rejection in the rat. Transplantation proceedings, 1994, Volume: 26, Issue:6 Topics: Animals; Aorta, Thoracic; Chronic Disease; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Leflunomide; Muscle, Smooth, Vascular; Rats; Rats, Inbred Lew; Rats, Inbred WF; Transplantation, Homologous; Tunica Intima	1994
Leflunomide therapy following penetrating keratoplasty in the rat. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1994, Volume: 232, Issue:10 Topics: Administration, Oral; Animals; Cornea; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Leflunomide; Random Allocation; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Homologous	1994
An evaluation of leflunomide in the canine renal transplantation model. Transplantation, 1994, Jun-27, Volume: 57, Issue:12 Topics: Administration, Oral; Animals; Creatinine; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Female; Graft Survival; Immunosuppressive Agents; Injections, Intravenous; Isoxazoles; Kidney Function Tests; Kidney Transplantation; Leflunomide; Time Factors	1994
Effect of leflunomide in control of acute rejection in hamster-to-rat cardiac xenografts. Transplantation proceedings, 1994, Volume: 26, Issue:3 Topics: Animals; Cricetinae; Cyclosporine; Dose-Response Relationship, Drug; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Lew; Regression Analysis; Time Factors; Transplantation, Heterologous; Transplantation, Heterotopic	1994
Leflunomide and cyclosporin-A prolong fish-to-mouse islet xenograft survival in BALB/C mice. Transplantation proceedings, 1994, Volume: 26, Issue:3 Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred BALB C; Tilapia; Transplantation, Heterologous	1994
Oral leflunomide prevents small bowel allograft rejection in the rat. Transplantation proceedings, 1994, Volume: 26, Issue:3 Topics: Administration, Oral; Animals; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Intestine, Small; Isoxazoles; Leflunomide; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Homologous	1994
Promotion of corneal allograft survival with leflunomide. Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:10 Topics: Administration, Oral; Animals; Cornea; Cyclosporine; Female; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Leflunomide; Rats; Rats, Inbred Lew; Rats, Inbred WF; Transplantation, Homologous	1994
Leflunomide in experimental transplantation. Control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporine. Transplantation, 1994, Apr-27, Volume: 57, Issue:8 Topics: Abdomen; Acute Disease; Animals; Antibody Formation; Cyclosporine; Drug Therapy, Combination; Empyema; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoantibodies; Isoxazoles; Leflunomide; Male; Models, Biological; Rats; Rats, Inbred BN; Rats, Inbred Lew; Rats, Sprague-Dawley; Transplantation, Heterotopic	1994
Elevated levels of TNF in the joints of adjuvant arthritic rats. Cytokine, 1993, Volume: 5, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Assay; Cells, Cultured; Cyclosporine; Edema; Freund's Adjuvant; Ibuprofen; Isoxazoles; Joints; L Cells; Leflunomide; Macrophages, Peritoneal; Male; Methotrexate; Mice; Mycobacterium tuberculosis; Rabbits; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha	1993
Leflunomide, a novel immunosuppressive agent. The mechanism of inhibition of T cell proliferation. Transplantation, 1993, Volume: 55, Issue:6 Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; CD3 Complex; Cyclosporine; Humans; Immunosuppressive Agents; In Vitro Techniques; Interleukin-2; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Receptors, Interleukin-2; Tetradecanoylphorbol Acetate	1993
Immunosuppressive effects of leflunomide in a cardiac allograft model. Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Heterotopic; Transplantation, Homologous	1993
Leflunomide, a novel immunomodulatory agent: in vitro analyses of the mechanism of immunosuppression. Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1 Topics: Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Polyenes; Sirolimus; T-Lymphocytes; Thymidine; Tritium	1993
Prolongation of allogeneic transplanted skin grafts and induction of tolerance by leflunomide, a new immunosuppressive isoxazol derivative. Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Strains; Skin Transplantation; Spleen; Time Factors; Transplantation, Homologous	1993
Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. Transplantation proceedings, 1995, Volume: 27, Issue:6 Topics: Animals; Antibodies, Heterophile; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Swine; Tacrolimus; Transplantation, Heterologous	1995
Effect of leflunomide and cyclosporine on the occurrence of chronic xenograft lesions. Kidney international. Supplement, 1995, Volume: 52 Topics: Animals; Antibody Formation; Cricetinae; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Transplantation, Heterologous	1995
Mechanisms involved in long-term hamster-to-rat cardiac xenograft survival. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Antibodies, Heterophile; Antigens, Heterophile; Cricetinae; Cyclosporine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Rats; Rats, Inbred Strains; Time Factors; Transplantation, Heterologous; Transplantation, Heterotopic	1996
Complete control of humoral and cell-mediated xenoreactions with the combination of leflunomide and cyclosporine. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Antibody Formation; Cricetinae; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Heart Transplantation; Immunity, Cellular; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Rats; Rats, Inbred Lew; Transplantation, Heterologous; Transplantation, Heterotopic	1996
Control and reversal of chronic xenograft rejection in hamster-to-rat cardiac transplantation. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Cricetinae; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Lew; Transplantation, Heterologous; Transplantation, Homologous	1996
Effect of leflunomide, cyclosporine, and splenectomy in two different organ systems of concordant xenotransplantation in rats. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Combined Modality Therapy; Cricetinae; Cyclosporine; Drug Therapy, Combination; Heart Transplantation; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Kidney Neoplasms; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Lew; Splenectomy; Transplantation, Heterologous	1996
Obliterative airway disease after heterotopic tracheal xenotransplantation in a concordant rodent model: pathogenesis and treatment. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Airway Obstruction; Animals; Bronchiolitis Obliterans; Cricetinae; Cyclosporine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Heterologous	1996
Immunosuppression with cyclosporin A in combination with leflunomide and mycophenolate mofetil prevents rejection of pig-islets transplanted into rats. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Antibodies, Heterophile; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Graft Rejection; Immunoglobulin G; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous	1996
Combined immunosuppression with leflunomide and cyclosporine prevents MLR-mismatched renal allograft rejection in a mongrel canine model. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Cyclosporine; Dogs; Drug Therapy, Combination; Female; Graft Rejection; Graft Survival; Histocompatibility Testing; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Culture Test, Mixed; Transplantation, Homologous	1996
Delayed xenograft rejection in the concordant hamster heart into Lewis rat model. Transplantation, 1996, Jul-15, Volume: 62, Issue:1 Topics: Acute Disease; Animals; Cricetinae; Cyclosporine; Drug Administration Schedule; Graft Rejection; Heart Transplantation; Immunity, Cellular; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Rats, Inbred Lew; Time Factors; Transplantation, Heterologous	1996
Flow-cytometric analysis of peripheral lymphocytes in the rat following penetrating keratoplasty and immunosuppressive treatment. German journal of ophthalmology, 1996, Volume: 5, Issue:3 Topics: Animals; Antibodies, Monoclonal; CD4 Antigens; Cyclosporine; Drug Combinations; Flow Cytometry; Fluorescent Antibody Technique, Direct; Graft Rejection; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Leflunomide; Lymphocytes; Random Allocation; Rats; Rats, Inbred BN; Rats, Inbred Lew	1996
Effects of leflunomide and cyclosporine on myocutaneous allograft survival in the rat. Transplantation, 1996, Sep-27, Volume: 62, Issue:6 Topics: Animals; Cyclosporine; Evoked Potentials; Graft Rejection; Graft Survival; Hindlimb; Immunosuppressive Agents; Isoxazoles; Leflunomide; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Neuromuscular Junction; Peripheral Nerves; Rats; Rats, Inbred BN; Rats, Inbred Lew; Skin Transplantation	1996
Immunomodulation of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin A. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:2 Topics: Animals; Arthritis; Autoantibodies; Cyclosporine; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Organ Size; Rats; Rats, Wistar; Serum Albumin, Bovine	1996
Leflunomide and cyclosporine immunomodulation in intestinal xenotransplantation. Transplantation proceedings, 1996, Volume: 28, Issue:5 Topics: Animals; Cricetinae; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Intestine, Small; Isoxazoles; Leflunomide; Mesocricetus; Rats; Rats, Inbred Lew; Time Factors; Transplantation, Heterologous	1996
A short-term combination therapy with cyclosporine and rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain combination in rats. Transplant international : official journal of the European Society for Organ Transplantation, 1996, Volume: 9 Suppl 1 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Polyenes; Rats; Rats, Inbred Strains; Sirolimus	1996
Control of mouse-to-rat skin xenograft rejection by malononitrilamides. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous	1996
Acute skin graft rejection can be prevented and treated in rat models by malononitrilamides. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Acute Disease; Alkynes; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Time Factors	1996
In vivo mechanism of action of leflunomide: selective inhibition of the capacity of B lymphocytes to make T-independent xenoantibodies. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; Cyclosporine; Flow Cytometry; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; T-Lymphocytes	1996
Progressive change in tolerance mechanisms after withdrawing combination immunosuppression with cyclosporine and rapamycine or leflunomide. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Polyenes; Rats; Rats, Inbred Strains; Sirolimus; T-Lymphocytes; Time Factors; Transplantation, Homologous	1996
In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function. Transplantation, 1997, Mar-15, Volume: 63, Issue:5 Topics: Animals; Body Weight; Cyclosporine; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Rats; Tacrolimus; Time Factors	1997
Efficacy of immunosuppressive drugs in islet xenotransplantation: leflunomide in combination with cyclosporine and mycophenolate mofetil prevents islet xenograft rejection in the pig-to-rat model. Transplantation, 1997, May-15, Volume: 63, Issue:9 Topics: Animals; Antibodies; Complement System Proteins; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Graft Rejection; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Mice; Pregnancy; Rats; Swine; Time Factors; Transplantation, Heterologous; Uridine	1997
Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs. Journal of pharmacological and toxicological methods, 1997, Volume: 37, Issue:2 Topics: Animals; C-Reactive Protein; Cyclosporine; Drug Evaluation, Preclinical; Female; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunosuppressive Agents; Indomethacin; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C	1997
Effect of leflunomide and cyclosporine on concordant xenogeneic islet transplantation in streptozotocin-induced and autoimmune diabetic mice. Transplantation proceedings, 1997, Volume: 29, Issue:4 Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Rats; Rats, Sprague-Dawley; Species Specificity; Transplantation, Heterologous	1997
Successful xenotransplantation of adult porcine islets in NOD and BALB/c mice with leflunomide and cyclosporine. Transplantation proceedings, 1997, Volume: 29, Issue:4 Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Graft Survival; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Swine; Transplantation, Heterologous	1997
Triple drug treatment with cyclosporine, leflunomide and mycophenolate mofetil prevents rejection of pig islets transplanted into rats and primates. Transplantation proceedings, 1997, Volume: 29, Issue:5 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Haplorhini; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous	1997
Quantitation of the changes in splenic architecture during the rejection of cardiac allografts or xenografts. Transplantation, 1997, Aug-15, Volume: 64, Issue:3 Topics: Animals; Antibody Formation; Antibody Specificity; Cricetinae; Cyclosporine; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Transplantation, Heterologous; Transplantation, Homologous	1997
Combination leflunomide and cyclosporine prevents rejection of functional whole limb allografts in the rat. Transplantation, 1997, Sep-27, Volume: 64, Issue:6 Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Hindlimb; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Peroneal Nerve; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sensation; Transplantation, Homologous; Transplantation, Isogeneic; Weight-Bearing	1997
Long-term xenograft survival by combination therapy of malononitrilamide MNA 715 with cyclosporine. Transplantation proceedings, 1997, Volume: 29, Issue:8 Topics: Alkynes; Animals; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous	1997
Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts. Transplantation, 1997, Dec-27, Volume: 64, Issue:12 Topics: Animals; Antibody Formation; Complement C3; Cricetinae; Cyclosporine; Graft Rejection; Heart Transplantation; Immunoglobulin M; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Rats; Rats, Inbred Lew; T-Lymphocytes; Time Factors	1997
Blockade of induced xenoantigen expression prevents rejection after retransplantation of accommodated hamster-to-rat heart xenografts. Transplantation, 1998, Feb-15, Volume: 65, Issue:3 Topics: Animals; Antibodies, Heterophile; Antigens, Heterophile; Cells, Cultured; Cricetinae; Cyclosporine; E-Selectin; Endothelium, Vascular; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Immunoglobulin M; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Isoxazoles; Leflunomide; Male; Mesocricetus; P-Selectin; Rats; Rats, Inbred Strains; Reoperation; Time Factors; Transplantation, Heterologous; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	1998
Synergistic activity of malononitrilamides with cyclosporine to control and reverse xenograft rejection. International journal of tissue reactions, 1997, Volume: 19, Issue:3-4 Topics: Alkynes; Animals; Antibody Formation; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Transplantation, Heterologous	1997
The effects of leflunomide and cyclosporin A on rejection of cardiac allografts in the rat. Scandinavian journal of immunology, 1998, Volume: 47, Issue:3 Topics: Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Wistar	1998
Accommodation and T-independent B cell tolerance in rats with long term surviving hamster heart xenografts. Journal of immunology (Baltimore, Md. : 1950), 1998, Jan-01, Volume: 160, Issue:1 Topics: Adoptive Transfer; Animals; Antibody Formation; Antigens, T-Independent; B-Lymphocytes; Complement C6; Cricetinae; Cyclosporine; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Rats; Rats, Inbred Strains; T-Lymphocytes; Time Factors; Transplantation, Heterologous	1998
Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. European journal of clinical pharmacology, 1998, Volume: 54, Issue:2 Topics: Anticonvulsants; Cyclosporine; Cytochrome P-450 Enzyme System; Dihydroergotamine; Drug Interactions; Humans; In Vitro Techniques; Isoxazoles; Itraconazole; Ketoconazole; Metabolic Clearance Rate; Miconazole; Triazolam; Zonisamide	1998
Malononitrilamides reduce IgM and IgG xenoantibodies and prolong skin xenograft survival in a mouse-to rat model. Transplantation proceedings, 1998, Volume: 30, Issue:4 Topics: Acute Disease; Alkynes; Animals; Antibodies, Heterophile; Antibody Formation; Cyclosporine; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Nitriles; Rats; Rats, Inbred Lew; Skin Transplantation; Time Factors; Transplantation, Heterologous	1998
Effect of leflunomide and cyclosporine on graft survival and changes in lymphocyte phenotypes in a rat heart allotransplantation model. Transplant immunology, 1998, Volume: 6, Issue:1 Topics: Animals; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cyclosporine; Graft Survival; Heart Transplantation; Immunophenotyping; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Homologous	1998
Synergism of the malononitrilamides 279 and 715 with cyclosporine A in the induction of long-term cardiac allograft survival. Transplant international : official journal of the European Society for Organ Transplantation, 1998, Volume: 11 Suppl 1 Topics: Alkynes; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Species Specificity; Time Factors	1998
Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine. Transplant international : official journal of the European Society for Organ Transplantation, 1998, Volume: 11 Suppl 1 Topics: Acute Disease; Alkynes; Animals; Cyclosporine; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Skin Transplantation	1998
Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model. Journal of immunology (Baltimore, Md. : 1950), 1998, Aug-15, Volume: 161, Issue:4 Topics: Acute Disease; Animals; Cricetinae; Cyclosporine; Disease Models, Animal; Drug Combinations; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Inbred Lew; Species Specificity; Time Factors; Transplantation, Heterologous	1998
Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation. Transplantation, 1998, Sep-27, Volume: 66, Issue:6 Topics: Animals; Chronic Disease; Cricetinae; Cyclosporine; Disease Models, Animal; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Myocardium; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Heterologous	1998
Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats. Transplant immunology, 1998, Volume: 6, Issue:2 Topics: Alkynes; Animals; Antibody Specificity; Autoantibodies; Cyclosporine; Drug Synergism; Graft Rejection; Heart Transplantation; Immunization; Immunosuppressive Agents; Isoxazoles; Male; Myocardium; Nitriles; Rats; Rats, Inbred Strains	1998
Malononitrilamides 715 and 279 prolong rat cardiac allograft survival, reverse ongoing rejection, inhibit allospecific antibody production and interact positively with cyclosporin. Scandinavian journal of immunology, 1998, Volume: 48, Issue:4 Topics: Alkynes; Aniline Compounds; Animals; Antibody Formation; Crotonates; Cyclosporine; Drug Interactions; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Hydroxybutyrates; Immunoglobulin Allotypes; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Strains; Toluidines; Transplantation, Homologous	1998
Irradiation or temporal variations in immunosuppressive schedules do not prevent graft-versus-host disease following rat limb allotransplantation. Transplantation proceedings, 1998, Volume: 30, Issue:8 Topics: Animals; Cyclosporine; Drug Administration Schedule; Extremities; Graft Rejection; Graft vs Host Disease; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Inbred BN; Rats, Inbred Lew; Time Factors; Transplantation, Homologous; Whole-Body Irradiation	1998
Potentiation of immunosuppressive efficacy by combining the novel leflunomide analog, HMR 279, with microemulsion cyclosporine in a rat lung transplant model. Transplantation, 1999, Feb-15, Volume: 67, Issue:3 Topics: Amides; Aniline Compounds; Animals; Biotransformation; Body Weight; Chromatography, High Pressure Liquid; Crotonates; Cyclosporine; Drug Therapy, Combination; Emulsions; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Transplantation; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Structure-Activity Relationship; Toluidines	1999
Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay. Immunology letters, 1999, Apr-15, Volume: 67, Issue:3 Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Biphenyl Compounds; Caproates; Crotonates; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Male; Nitriles; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Receptors, OX40; Receptors, Tumor Necrosis Factor; Toluidines; Tumor Necrosis Factor Receptor Superfamily, Member 7	1999
Efficacy of malononitriloamide 279 and 715 in islet xenotransplantation: a study in the pig-to-rat model. Transplantation proceedings, 2000, Volume: 32, Issue:5 Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Mycophenolic Acid; Nitriles; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous	2000
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days. Transplantation proceedings, 2000, Volume: 32, Issue:5 Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous	2000
Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. American journal of veterinary research, 2000, Volume: 61, Issue:8 Topics: Animals; Cats; Cell Division; Coloring Agents; Concanavalin A; Cyclosporine; Dose-Response Relationship, Drug; Immunosuppressive Agents; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Lymphocyte Activation; Mycophenolic Acid; Pokeweed Mitogens; Scintillation Counting; Sirolimus; Tacrolimus; Trypan Blue	2000
The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes. European journal of immunology, 2000, Volume: 30, Issue:12 Topics: Actin Depolymerizing Factors; Cyclosporine; Dexamethasone; Humans; Isoxazoles; Leflunomide; Microfilament Proteins; Mycophenolic Acid; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Sirolimus; T-Lymphocytes; Tacrolimus	2000
The immunomodulatory effects of a novel agent, leflunomide, in rat cardiac allotransplantation. Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7 Suppl 1 Topics: Animals; Body Weight; Cyclosporine; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Tacrolimus; Time Factors; Transplantation, Homologous	1994
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days. Transplantation, 2001, Apr-27, Volume: 71, Issue:8 Topics: Animals; Antibodies, Heterophile; Blood Glucose; C-Peptide; Cell Culture Techniques; Cell Separation; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Female; Graft Survival; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Macrophages; Mice; Mice, Nude; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous	2001
Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice. Transplantation proceedings, 2001, Volume: 33, Issue:3 Topics: Alkynes; Animals; Cyclosporine; Diabetes Mellitus, Type 1; Drug Synergism; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred NOD; Nitriles; Rats; Transplantation, Heterologous	2001
Efficacy of malononitrilamide 715 as immunosuppressant, alone or in combination with cyclosporin, in allogeneic foetal rat pancreatic transplantation. Transplantation proceedings, 2001, Volume: 33, Issue:3 Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Fetal Tissue Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Pancreas Transplantation; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Subrenal Capsule Assay; T-Lymphocytes; Transplantation, Homologous; Weight Gain; Weight Loss	2001
Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation. Transplantation proceedings, 2001, Volume: 33, Issue:3 Topics: Aniline Compounds; Animals; Antigens, Heterophile; B-Lymphocytes; Biphenyl Compounds; Cell Division; Crotonates; Cyclosporine; Drug Resistance; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphoma, B-Cell; Mycophenolic Acid; Nitriles; Primates; Pyrazoles; Swine; T-Lymphocytes; Toluidines; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Conventional DMARD options for patients with a suboptimal response to methotrexate. The Journal of rheumatology. Supplement, 2001, Volume: 62 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine	2001
Benefits of leflunomide in systemic lupus erythematosus: a pilot observational study. Lupus, 2001, Volume: 10, Issue:7 Topics: Adult; Blood Sedimentation; Cyclosporine; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Methotrexate; Pilot Projects; Retrospective Studies	2001
Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. Transplantation, 2001, Nov-15, Volume: 72, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cells, Cultured; Culture Media; Cyclosporine; Endothelium, Vascular; Humans; Isoxazoles; Leflunomide; Mice; Microcirculation; Models, Animal; Tacrolimus; Umbilical Veins; Uridine	2001
A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs. Surgery, 2002, Volume: 132, Issue:1 Topics: Alkynes; Animals; Cyclosporine; Dogs; Female; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Tacrolimus	2002
Immunosuppressive drugs in islet xenotransplantation: a tool for gaining further insights in the mechanisms of the rejection process. Transplantation, 2002, Oct-27, Volume: 74, Issue:8 Topics: Actins; Animals; Anti-Inflammatory Agents; Antibodies, Heterophile; Cyclosporine; Female; Fetal Tissue Transplantation; Graft Rejection; Guanidines; Immunosuppressive Agents; Interleukins; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Prednisolone; Pregnancy; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Tacrolimus; Transplantation, Heterologous	2002
[Evidence-based treatment of methotrexate-resistant rheumatoid arthritis. Combinations of conventional disease-modifying antirheumatic agents]. Deutsche medizinische Wochenschrift (1946), 2003, Jan-24, Volume: 128, Issue:4 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Placebos; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors	2003
Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs. Transplantation, 2003, Apr-27, Volume: 75, Issue:8 Topics: Alkynes; Animals; Cyclosporine; Dogs; Drug Therapy, Combination; Emulsions; Graft Survival; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Nitriles; Osmolar Concentration	2003
Histological and immunological characteristics of, and the effect of immunosuppressive treatment on, xenograft vasculopathy. Xenotransplantation, 2004, Volume: 11, Issue:2 Topics: Animals; Antibodies, Heterophile; Aorta; Cricetinae; Cyclosporine; Drug Therapy, Combination; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Rats; Rats, Inbred Lew; Rats, Nude; Tissue and Organ Harvesting; Transplantation, Heterologous	2004
[When to begin rheumatism treatment? Initial combination therapy helps fastest]. MMW Fortschritte der Medizin, 2004, Sep-09, Volume: 146, Issue:37 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
[Three joints swollen, blood sedimentation increased. Methotrexate to be given immediately?]. MMW Fortschritte der Medizin, 2004, Sep-09, Volume: 146, Issue:37 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
Toward the definition of immunosuppressive regimens with antitumor activity. Transplantation proceedings, 2005, Volume: 37, Issue:5 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cyclosporine; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Jurkat Cells; Leflunomide; Liver Neoplasms; Mycophenolic Acid; Rhabdomyosarcoma; Sirolimus	2005
P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments. Human psychopharmacology, 2005, Volume: 20, Issue:7 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Brain; Cyclosporine; Drug Interactions; In Vitro Techniques; Isoxazoles; Liver; Mass Spectrometry; Mice; Mice, Knockout; Nortriptyline; Paliperidone Palmitate; Pyrimidines	2005
The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. Transplantation proceedings, 2006, Volume: 38, Issue:8 Topics: Alkynes; Animals; Cyclosporine; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous	2006
The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression. Transplantation proceedings, 2006, Volume: 38, Issue:10 Topics: Alkynes; Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Nitriles; Rats; Rats, Inbred WF; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous; Transplantation, Isogeneic	2006
Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778. Transplantation, 2008, Mar-27, Volume: 85, Issue:6 Topics: Alkynes; Animals; Aorta; Aortic Diseases; Chronic Disease; Cyclosporine; Immunosuppressive Agents; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred ACI; Transplantation, Homologous	2008
[Psoriatic arthritis]. Annales de dermatologie et de venereologie, 2008, Volume: 135 Suppl 4 Topics: Arthritis, Psoriatic; Cyclosporine; Diagnosis, Differential; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Psoriasis	2008
FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:11 Topics: Alkynes; Animals; Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Male; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred WF; Risk Factors; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous	2008
The effects of PDTC plus leflunomide and cyclosporine on the NF-kappaB signaling pathway in mouse-to-rat cardiac xenografts. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2009, Volume: 29, Issue:2 Topics: Animals; Cyclosporine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mice; NF-kappa B; Pyrrolidines; Rats; Rats, Wistar; Signal Transduction; Thiocarbamates; Transplantation, Heterologous	2009
[Hepatotoxicity induced by new immunosuppressants]. Gastroenterologia y hepatologia, 2010, Volume: 33, Issue:1 Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha	2010
Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs. Transplantation, 2009, Nov-27, Volume: 88, Issue:10 Topics: Adult; Aged; BK Virus; Cyclosporine; Female; Humans; Immunosuppressive Agents; Interferon-gamma; Isoxazoles; Kidney Transplantation; Leflunomide; Middle Aged; Mycophenolic Acid; Polyomavirus Infections; Reference Values; T-Lymphocytes; Tacrolimus	2009
[Active psoriatic arthritis during pregnancy: challenges and limitations of pharmacotherapy]. Annales Academiae Medicae Stetinensis, 2010, Volume: 56 Suppl 1 Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Contraindications; Cyclosporine; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Prednisone; Pregnancy; Pregnancy Complications; Sulfasalazine	2010
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury. European heart journal, 2013, Volume: 34, Issue:24 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Chenodeoxycholic Acid; Cyclosporine; Cytochromes c; Enzyme Inhibitors; Isoxazoles; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pregnenediones; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering	2013
Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo. Transplant immunology, 2012, Volume: 27, Issue:1 Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cell Count; Cyclophosphamide; Cyclosporine; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immune Tolerance; Immunity; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Mycophenolic Acid; Ovalbumin; Propylene Glycols; Sirolimus; Sphingosine; Spleen; T-Lymphocytes, Regulatory	2012
Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-γ) production of four novel leflunomide analogues. Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Humans; Immunologic Factors; Interferon-gamma; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Structure-Activity Relationship	2012
In-vitro immunosuppression of canine T-lymphocyte-specific proliferation with dexamethasone, cyclosporine, and the active metabolites of azathioprine and leflunomide in a flow-cytometric assay. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2014, Volume: 78, Issue:3 Topics: Aniline Compounds; Animals; Azathioprine; Cell Proliferation; Crotonates; Cyclosporine; Dexamethasone; Dogs; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mercaptopurine; Nitriles; T-Lymphocytes; Toluidines	2014
Psoriatic arthritis treatment and the risk of herpes zoster. Annals of the rheumatic diseases, 2016, Volume: 75, Issue:1 Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Azathioprine; Cyclosporine; Drug Combinations; Drug Therapy, Combination; Etanercept; Female; Glucosamine; Herpes Zoster; Humans; Hydroxychloroquine; Incidence; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Tumor Necrosis Factor-alpha	2016
Variability in the prescription of non-biologic disease-modifying antirheumatic drugs for the treatment of spondyloarthritis in Spain. Seminars in arthritis and rheumatism, 2015, Volume: 44, Issue:6 Topics: Adult; Antimalarials; Antirheumatic Agents; Azathioprine; Cohort Studies; Cyclophosphamide; Cyclosporine; Female; Humans; Inflammatory Bowel Diseases; Isoxazoles; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Odds Ratio; Practice Patterns, Physicians'; Psoriasis; Retrospective Studies; Severity of Illness Index; Sex Factors; Spain; Spondylarthropathies; Sulfasalazine; Uveitis	2015
Systemic antipsoriatic combination therapy with fumaric acid esters for plaque-type psoriasis: report on 17 cases. Dermatology (Basel, Switzerland), 2015, Volume: 230, Issue:2 Topics: Acitretin; Adult; Aged; Anti-Inflammatory Agents; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Etanercept; Female; Fumarates; Germany; Humans; Infliximab; Isoxazoles; Keratolytic Agents; Leflunomide; Male; Methotrexate; Middle Aged; Prednisolone; Psoriasis; Retrospective Studies	2015
Systemic Therapy for Psoriasis and the Risk of Herpes Zoster: A 500,000 Person-year Study. JAMA dermatology, 2015, Volume: 151, Issue:5 Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Biological Factors; Causality; Cohort Studies; Comorbidity; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Herpes Zoster; Herpes Zoster Vaccine; Humans; Incidence; Isoxazoles; Male; Methotrexate; Middle Aged; Multivariate Analysis; Phototherapy; Psoriasis; Risk Factors; Sex Distribution; Ustekinumab	2015
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study. Clinical rheumatology, 2015, Volume: 34, Issue:6 Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha	2015
[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2015, Volume: 51, Issue:10 Topics: Animals; Autoimmune Diseases; Cyclosporine; Down-Regulation; Eye Proteins; Immunosuppressive Agents; Interferon-gamma; Interleukin-17; Isoxazoles; Leflunomide; Random Allocation; Rats; Rats, Inbred Lew; Retinitis; Retinol-Binding Proteins; RNA, Messenger; Th17 Cells; Uveitis	2015
Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society, 2017, Volume: 19, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Cyclosporine; Diagnosis, Differential; Hair Diseases; Hair Follicle; Humans; Immunologic Factors; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver Transplantation; Male; Polyomavirus Infections; Pruritus	2017