isoxazoles has been researched along with bicuculline in 103 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (58.25) | 18.7374 |
| 1990's | 18 (17.48) | 18.2507 |
| 2000's | 14 (13.59) | 29.6817 |
| 2010's | 11 (10.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gale, KN; Guidotti, A | 1 |
| Gallager, DW; Tallman, JF; Thomas, JW | 1 |
| Mohler, H; Okada, T | 1 |
| Curtis, DR; Johnston, GA; Krogsgaard-Larsen, P; Lodge, D | 1 |
| Snodgrass, SR | 1 |
| Polc, P | 1 |
| Braestrup, C; Falch, E; Krogsgaard-Larsen, P; Nielsen, M | 1 |
| Andrews, PR; Johnston, GA | 1 |
| Boissier, JR; Dumont, C; Oberlander, C | 1 |
| Arnt, J; Scheel-Krüger, J | 1 |
| Leach, MJ; Wilson, JA | 1 |
| Andre, JM; Boulanger, T; Durant, F; Hoffmann, R; Rognan, D; Vercauteren, DP; Wermuth, CG | 1 |
| Johnston, GA | 1 |
| Bonaventure, N; Jardon, B; Kim, MS; Yücel, H | 1 |
| Ebbesson, SO; Erdö, SL; Hofmann, MH; Malz, CR; Meyer, DL | 1 |
| Bapna, JS; Ramaswamy, S; Srinivasan, D | 1 |
| Agmo, A; Gutiérrez, M; Guzmán, M; Pruneda, R | 1 |
| Bergen, HT; Hejtmancik, JF; Pfaff, DW | 1 |
| Fromm, GH; Mukawa, J; Nakata, M | 1 |
| Heinricher, MM; Kaplan, HJ | 1 |
| Falch, E; Kristiansen, U; Krogsgaard-Larsen, P; Lambert, JD | 1 |
| Hicks, TP; Kaneko, T | 1 |
| Amenta, F; Erdö, SL; Mione, MC; Wolff, JR | 1 |
| Agmo, A; Paredes, R; Soria, P | 1 |
| Bapna, JS; Ramaswamy, S; Suthakaran, C | 1 |
| Graeff, FG; Milani, H | 1 |
| Fujimoto, M; Guidotti, A; Hanbauer, I; Kataoka, Y | 1 |
| Pooler, GW; Steward, EG | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Byberg, JR; Curtis, DR; Falch, E; Gynther, BD; Hjeds, H; Krogsgaard-Larsen, P; Labouta, IM | 1 |
| Alho, H; Fujimoto, M; Geffard, M; Guidotti, A; Hanbauer, I; Kataoka, Y; Kelly, GD | 1 |
| Bagri, A; Di Scala, G; Sandner, G | 1 |
| Iversen, LL; Wong, EH | 1 |
| Agmo, A; Paredes, R | 1 |
| Agmo, A; Giordano, M | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Nielsen, L | 1 |
| Depaulis, A; Vergnes, M | 3 |
| Brandao, ML; Di Scala, G; Karli, P; Schmitt, P | 1 |
| Bristow, DR; Watling, KJ | 1 |
| Allan, AM; Harris, RA | 1 |
| Belhage, B; Meier, E; Schousboe, A | 1 |
| Apud, JA; Masotto, C; Racagni, G | 1 |
| Chweh, AY; Swinyard, EA; Wolf, HH | 1 |
| Lindgren, S | 1 |
| DaSilva, AM; Gatti, PJ; Gillis, RA | 1 |
| Gillis, RA; Hamosh, P; Hartley, B; Quest, JA; Taveira da Silva, AM | 1 |
| Drower, EJ; Hammond, DL | 1 |
| Zarkovsky, AM | 1 |
| Borsini, F; Evangelista, S; Meli, A | 1 |
| Sawynok, J | 1 |
| Karobath, M; Supavilai, P | 1 |
| Benson, DI; Klepner, CA; Squires, RF | 1 |
| Carmona, E; Gomes, C; Trolin, G | 1 |
| Cavagnini, F; Grandison, L; Guidotti, A; Invitti, SC; Schmid, R | 1 |
| Blavet, N; Clostre, F; DeFeudis, FV | 1 |
| Dias Souza, J; Gillis, RA; Quest, JA; Williford, DJ | 1 |
| Dutton, GR; Freedman, EG; Pearce, BR | 1 |
| Breese, GR; Frye, GD | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ | 1 |
| Maksay, G; Ticku, MK | 1 |
| Bloch, R; Bousquet, P; Feldman, J; Schwartz, J | 1 |
| Di Scala, G; Karli, P; Schmitt, P | 1 |
| Baumeister, AA; Frye, GD | 1 |
| DeFeudis, FV; Grognet, A; Hertz, F | 1 |
| Mueller, AL; Schwartzkroin, PA; Taube, JS | 1 |
| Coward, DM | 1 |
| Cheney, DL; McGill, W; Murray, TF | 1 |
| Alger, BE; Nicoll, RA | 1 |
| Aghajanian, GK; Gellman, RL | 1 |
| Abdulla, FA; Calaminici, MR; Gray, JA; Raevsky, VV; Sinden, JD; Stephenson, JD | 1 |
| Liske, S; Morris, ME | 1 |
| Kim, HY; Olsen, RW; Sapp, DW; Tobin, AJ | 1 |
| Matsutani, S; Yamamoto, N | 1 |
| Bedingfield, JB; Calder, LD; Karler, R; Thai, DK | 1 |
| Agmo, A; Contreras, JL; Paredes, RG | 1 |
| Lerma, J; López-García, JC; Rodríguez-Moreno, A | 1 |
| Kulinskii, VI; Mikhel'son, GV | 1 |
| Ebert, B; Fjalland, B; Hansen, SL; Kristiansen, U | 1 |
| Brünig, I; Fritschy, JM; Studler, B | 1 |
| Platt, B; White, AM | 1 |
| Frosini, M; Sgaragli, G; Valoti, M | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Gong, QH; Shen, H; Smith, SS; Yuan, M | 1 |
| Goldstein, PA; Harrison, NL; Jia, F; Pignataro, L; Schofield, CM; Yue, M | 1 |
| Jia, H; Qu, CL; Tang, JS | 1 |
| Park, JB; Skalska, S; Son, S; Stern, JE | 1 |
| Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD | 1 |
| Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V | 1 |
| Balfour, DJ; Belelli, D; Brown, VJ; Chandra, D; Foister, N; Herd, MB; Homanics, GE; Lambert, JJ; Peden, DR | 1 |
| Belcastro, V; Calabresi, P; Costa, C; Ientile, R; Luchetti, E; Picconi, B; Pisani, F; Siliquini, S; Tantucci, M; Tozzi, A | 1 |
| Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J | 1 |
| Bonin, RP; De Koninck, Y; Eng, DG; Labrakakis, C; Orser, BA; Whissell, PD | 1 |
| Dretchen, KL; Gillis, RA; Herman, MA; Sahibzada, N; Vicini, S | 1 |
| Charbonnet, M; Gold, MS; Lee, KY | 1 |
| Kalappa, BI; Uteshev, VV | 1 |
| Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG | 1 |
| Bondy, B; Cui, N; Jiang, C; Jin, X; Johnson, CM; Oginsky, MF; Wu, Y; Zhang, S; Zhong, W | 1 |
| Bohnsack, JP; Carlson, SL; Morrow, AL; Patel, V | 1 |
| Johnston, GAR | 1 |
| Browning, KN; McMenamin, CA; Travagli, RA | 1 |
3 review(s) available for isoxazoles and bicuculline
| Article | Year |
|---|---|
GABAA agonists as targets for drug development.
Topics: Acetates; Acrylates; Amines; Analgesics; Anthelmintics; Anticonvulsants; Bicuculline; Computer Simulation; Cyclohexanecarboxylic Acids; Cyclopentanes; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Molecular Weight; Receptors, GABA-A | 1992 |
Molecular pharmacology of the GABA receptors and GABA agonists.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Humans; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism; Synapses | 1983 |
GABA Australis, some reflections on the history of GABA receptor research in Australia.
Topics: Animals; Australia; Baclofen; Bicuculline; Cyclic AMP; Humans; Isoxazoles; Muscimol; Receptors, GABA | 2017 |
100 other study(ies) available for isoxazoles and bicuculline
| Article | Year |
|---|---|
GABA-mediated control of rat neostriatal tyrosine hydroxylase revealed by intranigral muscimol.
Topics: Aminobutyrates; Animals; Bicuculline; Caudate Nucleus; Corpus Striatum; Dopamine; Enzyme Activation; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Neural Pathways; Olfactory Bulb; Oxazoles; Pimozide; Pteridines; Quaternary Ammonium Compounds; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 1976 |
GABAergic modulation of benzodiazepine binding site sensitivity.
Topics: Amanita; Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Neurotransmitter Agents; Rats; Receptors, Drug; Receptors, Neurotransmitter | 1978 |
GABA receptor binding with 3H (+) bicuculline-methiodide in rat CNS.
Topics: Aminobutyrates; Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebellum; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isoquinolines; Isoxazoles; Kinetics; Rats; Receptors, Neurotransmitter; Stereoisomerism; Taurine | 1977 |
A new class of GABA agonist.
Topics: Action Potentials; Aminobutyrates; Animals; Bicuculline; Biological Transport; Cats; gamma-Aminobutyric Acid; Interneurons; Isonicotinic Acids; Isoxazoles; Molecular Conformation; Neural Inhibition; Oxazoles; Receptors, Neurotransmitter; Spinal Cord; Structure-Activity Relationship; Synaptic Transmission | 1977 |
Use of 3H-muscimol for GABA receptor studies.
Topics: Aminobutyrates; Animals; Bicuculline; Binding, Competitive; Brain; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Oxazoles; Potassium; Rats; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1978 |
Effects of GABA-mimetic agents on the cat spinal cord.
Topics: Animals; Bicuculline; Cats; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Ibotenic Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neurons, Afferent; Spinal Cord | 1979 |
Partial agonists for brain GABA/benzodiazepine receptor complex.
Topics: Animals; Benzodiazepines; Bicuculline; Brain; Crotonates; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, Drug; Sulfonic Acids | 1979 |
Conformational analysis of muscimol, a GABA agonist.
Topics: Bicuculline; Binding Sites; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Molecular Conformation; Muscimol; Oxazoles; Quantum Theory | 1979 |
Rotational behaviour after unilateral intranigral injection of muscimol in rats.
Topics: Aminobutyrates; Animals; Basidiomycota; Behavior; Bicuculline; gamma-Aminobutyric Acid; Humans; Injections; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Stereotyped Behavior; Substantia Nigra; Time Factors | 1977 |
GABA in the ventral tegmental area: differential regional effects on locomotion, aggression and food intake after microinjection of GABA agonists and antagonists.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Bicuculline; Carbachol; Cerebral Cortex; Dopamine; Feeding Behavior; gamma-Aminobutyric Acid; Haloperidol; Humans; Isoxazoles; Male; Methyltyrosines; Morphine; Motor Activity; Muscimol; Picrotoxin; Rats; Reserpine | 1979 |
GABA receptor binding with 3H-muscimol in calf cerebellum.
Topics: Aminobutyrates; Animals; Bicuculline; Cattle; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Oxazoles; Receptors, Drug | 1978 |
Structure and molecular modeling of GABAA receptor antagonists.
Topics: Alkaloids; Androstanes; Azasteroids; Azepines; Bicuculline; Crystallization; Dibenzazepines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Isoxazoles; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship; Tubocurarine; X-Ray Diffraction | 1992 |
Pharmacological study of the chicken's monocular optokinetic nystagmus: effects of GABAergic agonist and antagonists.
Topics: Animals; Bicuculline; Chickens; Electroretinography; Eye Movements; Injections; Isoxazoles; Nystagmus, Optokinetic; Picrotoxin; Receptors, GABA-A; Retina; Vision, Monocular; Visual Pathways | 1992 |
Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
Topics: Aging; Aminobutyrates; Analgesics; Animals; Baclofen; Bicuculline; Binding, Competitive; Brain; Female; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Male; Muscimol; Receptors, GABA-A; Salmon; Sexual Behavior, Animal | 1992 |
Inhibition of tetrahydroisoxazolo-pyridin-3-ol and muscimol and its mechanism on gastrointestinal transit in mice.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Isoxazoles; Male; Mice; Muscimol; Phentolamine; Propranolol; Yohimbine | 1992 |
GABAergic drugs and conflict behavior in the rat: lack of similarities with the actions of benzodiazepines.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Behavior, Animal; Benzodiazepines; Bicuculline; Brain; Conflict, Psychological; Drug Interactions; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1991 |
Effects of gamma-aminobutyric acid receptor agonists and antagonist on LHRH-synthesizing neurons as detected by immunocytochemistry and in situ hybridization.
Topics: Animals; Baclofen; Bicuculline; Female; GABA-A Receptor Antagonists; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Immunohistochemistry; Isoxazoles; Neurons; Nucleic Acid Hybridization; Ovariectomy; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; RNA Probes; RNA, Messenger | 1991 |
Why are most GABA agonists not effective antiepileptic drugs?
Topics: Animals; Anticonvulsants; Bicuculline; Cats; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Receptors, GABA-A; Synaptic Transmission; Trigeminal Nucleus, Spinal | 1991 |
GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat.
Topics: Analgesics; Anesthesia; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter | 1991 |
Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.
Topics: Animals; Bicuculline; Cells, Cultured; Female; Hippocampus; Isonicotinic Acids; Isoxazoles; Membrane Potentials; Neurons; Piperidines; Pregnancy; Rats; Receptors, GABA-A; Spinal Cord | 1991 |
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Physical Stimulation; Somatosensory Cortex; Synapses | 1990 |
Binding of [3H]-muscimol to GABAA sites in the guinea-pig urinary bladder: biochemical assay and autoradiography.
Topics: Animals; Autoradiography; Bicuculline; Binding, Competitive; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Isoxazoles; Muscimol; Receptors, GABA-A; Tritium; Urinary Bladder | 1989 |
GABAergic drugs and lordosis behavior in the female rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine | 1989 |
Role of GABAergic system in prolactin analgesia.
Topics: Analgesics; Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Prolactin | 1989 |
GABA-benzodiazepine modulation of aversion in the medial hypothalamus of the rat.
Topics: Animals; Avoidance Learning; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Flumazenil; Hypothalamus, Middle; Isoxazoles; Male; Microinjections; Midazolam; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland.
Topics: Adrenal Medulla; Analgesics; Animals; Bicuculline; Catecholamines; Dogs; Electric Stimulation; Enkephalins; Female; Isoxazoles; Oxazoles; Receptors, GABA-A; Splanchnic Nerves | 1987 |
Structural factors governing agonist and antagonist activity in the GABAA system.
Topics: Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Receptors, GABA-A; Structure-Activity Relationship | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
Topics: Animals; Bicuculline; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Isoxazoles; Oxazoles; Piperidines; Pyrrolidines; Rats; Receptors, GABA-A; Synaptic Membranes | 1987 |
Intrinsic gamma aminobutyric acid receptors modulate the release of catecholamine from canine adrenal gland in situ.
Topics: Adrenal Medulla; Animals; Baclofen; Bicuculline; Chromaffin Granules; Dogs; Electric Stimulation; Epinephrine; Female; Hexamethonium; Hexamethonium Compounds; Histocytochemistry; Isoxazoles; Muscimol; Naloxone; Norepinephrine; Receptors, GABA-A; Splanchnic Nerves | 1986 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine | 1985 |
GABAergic drugs and sexual behaviour in the male rat.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1985 |
The locomotor-reducing effects of GABAergic drugs do not depend on the GABAA receptor.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Isoxazoles; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taurine | 1985 |
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Topics: Animals; Bicuculline; Brain; Cats; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Oxazolidinones; Piperidines; Rats; Receptors, GABA-A; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1985 |
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.
Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1985 |
Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray.
Topics: Animals; Behavior, Animal; Bicuculline; Escape Reaction; Hypothalamus, Middle; Isoxazoles; Male; Mesencephalon; Microinjections; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Superior Colliculi | 1985 |
GABAB receptor-mediated enhancement of vasoactive intestinal peptide-stimulated cyclic AMP production in slices of rat cerebral cortex.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Baclofen; Bicuculline; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasoactive Intestinal Peptide | 1986 |
gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Baclofen; Bicuculline; Brain; Cell Membrane; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Liver; Male; Mice; Mice, Inbred DBA; Muscimol; Picrotoxin; Receptors, GABA-A; Sodium; Sulfates; Taurine; Temperature | 1986 |
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Intracellular Membranes; Isoxazoles; Kinetics; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Hypnotic action of pentobarbital in mice: a possible mechanism.
Topics: Animals; Baclofen; Bicuculline; Isoxazoles; Male; Mice; Oxazoles; Pentobarbital; Receptors, GABA-A; Reflex; Sleep | 1987 |
Effects of GABAergic drugs on the GABA turnover in the substantia nigra and the corpus striatum of the rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Corpus Striatum; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1987 |
Cardiorespiratory effects produced by injecting drugs that affect GABA receptors into nuclei associated with the ventral surface of the medulla.
Topics: Animals; Bicuculline; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Female; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Muscimol; Respiration; Synaptic Transmission | 1987 |
Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat.
Topics: Animals; Baclofen; Bicuculline; Cats; Female; Heart; Injections, Intravenous; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, GABA-A; Respiration | 1987 |
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1988 |
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium | 1987 |
Effect of GABAergic drugs in the behavioral 'despair' test in rats.
Topics: Acetates; Aminooxyacetic Acid; Animals; Baclofen; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Muscimol; Oxazoles; Picrotoxin; Rats | 1986 |
GABAergic mechanisms in antinociception.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin | 1984 |
Involvement of central GABAergic receptors in the control over offensive and defensive behaviours in the rat.
Topics: Aggression; Animals; Bicuculline; Electroshock; Humans; Injections, Intraventricular; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Binding Sites; Cerebellum; Chlorides; Etazolate; Flunitrazepam; Isoxazoles; Male; Muscimol; Nicotinic Acids; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium | 1981 |
Multiple benzodiazepine receptor complexes: some benzodiazepine recognition sites are coupled to GABA receptors and ionophores.
Topics: Animals; Anions; Benzodiazepines; Bicuculline; Brain; Buffers; Flunitrazepam; gamma-Aminobutyric Acid; Haplorhini; Hot Temperature; Ionophores; Isonicotinic Acids; Isoxazoles; Macromolecular Substances; Papio; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter | 1980 |
Role of GABA-ergic receptors for the synthesis of GABA in different compartments of the rat cerebellum.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Male; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
gamma-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue.
Topics: Adult; Aged; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Middle Aged; Muscimol; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1982 |
Orally administered THIP inhibits food intake in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Dose-Response Relationship, Drug; Eating; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Central cardiovascular effects produced by the GABA receptor agonist drug, THIP.
Topics: Animals; Autonomic Nervous System; Bicuculline; Blood Pressure; Brain; Cats; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Autoreceptors modify the evoked release of [3H]GABA from cerebellar neurons in dissociated cell culture.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Fluspirilene; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Neurons; Potassium; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
GABAergic modulation of ethanol-induced motor impairment.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminobutyrates; Aminocaproates; Animals; Bicuculline; Brain; Ethanol; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Skills; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
Diazotization and thiocyanate differentiate agonists from antagonists for the high- and low-affinity receptors of gamma-aminobutyric acid.
Topics: Androstanes; Animals; Azasteroids; Benzenesulfonates; Bicuculline; Cerebral Cortex; Diazonium Compounds; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids; Thiocyanates; Tubocurarine | 1984 |
Pharmacological analysis of the central cardiovascular effects of four GABA analogues.
Topics: Animals; Atropine; Bicuculline; Blood Pressure; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Isonicotinic Acids; Isoxazoles; Kainic Acid; Muscimol; Pyrones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Flight induced by infusion of bicuculline methiodide into periventricular structures.
Topics: Animals; Bicuculline; Brain Mapping; Escape Reaction; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus, Middle; Isoxazoles; Male; Motor Activity; Periaqueductal Gray; Rats; Rats, Inbred Strains | 1984 |
Self-injurious behavior in rats produced by intranigral microinjection of GABA agonists.
Topics: Animals; Baclofen; Bicuculline; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Inbred Strains; Self Mutilation; Stress, Physiological; Substantia Nigra | 1984 |
Comparison of the analgesic actions of THIP and morphine.
Topics: Analgesics; Animals; Atropine; Benzoquinones; Bicuculline; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Morphine; Naloxone; Oxazoles; Quinones; Reaction Time | 1983 |
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist.
Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time | 1983 |
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neurons; Rabbits; Synapses | 1984 |
Nigral actions of GABA agonists are enhanced by chronic fluphenazine and differentiated by concomitant flurazepam.
Topics: Animals; Baclofen; Bicuculline; Female; Fluphenazine; Flurazepam; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1982 |
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212).
Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors | 1983 |
Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro.
Topics: Animals; Bicuculline; Dendrites; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Penicillins; Pentobarbital; Pyramidal Tracts; Rats; Receptors, Drug | 1982 |
Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: antagonism by atypical antipsychotic drugs.
Topics: Action Potentials; Animals; Antipsychotic Agents; Bicuculline; Cerebral Cortex; Chlorpromazine; Clozapine; Electrophysiology; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Risperidone; Serotonin Antagonists | 1994 |
An iontophoretic study of the effects of alpha-amino-hydroxy-5-methyl-4-isoxazole propionic acid lesions of the nucleus basalis magnocellularis on cholinergic and GABAergic influences on frontal cortex neurones of rats.
Topics: Acetylcholine; Animals; Bicuculline; Carbachol; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Isoxazoles; Male; Medulla Oblongata; Neurons; Parasympathetic Nervous System; Propionates; Rats; Rats, Sprague-Dawley | 1994 |
Extrasynaptic effects of GABA (gamma-aminobutyric acid) agonists on myelinated axons of peripheral nerve.
Topics: Action Potentials; Animals; Axons; Baclofen; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Motor Neurons; Nerve Fibers, Myelinated; Peripheral Nerves; Rana catesbeiana; Ranidae; Sciatic Nerve; Spinal Nerve Roots; Synapses | 1994 |
GABA alters GABAA receptor mRNAs and increases ligand binding.
Topics: Animals; Anticonvulsants; Base Sequence; Bicuculline; Cells, Cultured; Cerebellum; DNA Primers; gamma-Aminobutyric Acid; Gene Expression; Isoxazoles; Macromolecular Substances; Molecular Sequence Data; Muscimol; Neurons; Polymerase Chain Reaction; Rats; Receptors, GABA-A; RNA, Messenger | 1993 |
Neuronal regulation of astrocyte morphology in vitro is mediated by GABAergic signaling.
Topics: Animals; Animals, Newborn; Astrocytes; Baclofen; Bicuculline; Cell Adhesion; Cells, Cultured; Coculture Techniques; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Isoxazoles; Muscimol; Neurons; Rats; Rats, Wistar; Signal Transduction; Sodium Channel Blockers; Tetrodotoxin; Time Factors | 1997 |
The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine.
Topics: Amphetamine; Animals; Bicuculline; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Frontal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Models, Neurological; Motor Activity; Stereotyped Behavior; Sulpiride | 1998 |
GABAergic drugs and sexual behaviour in the rabbit: evidence for species-specific effects.
Topics: Animals; Baclofen; Bicuculline; Copulation; Dose-Response Relationship, Drug; Escape Reaction; GABA Agents; Isoxazoles; Male; Picrotoxin; Rabbits; Rats; Sexual Behavior, Animal; Species Specificity; Structure-Activity Relationship | 1998 |
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indoles; Interneurons; Isoxazoles; Kainic Acid; Lidocaine; Maleimides; Naphthalenes; Nerve Tissue Proteins; Patch-Clamp Techniques; Propionates; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 2000 |
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred CBA; Muscimol; Neuroprotective Agents; Picrotoxin | 2000 |
Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Cerebral Cortex; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Oocytes; Patch-Clamp Techniques; Piperidines; Pyridazines; Receptors, GABA-A; Xenopus laevis | 2001 |
GABAergic and glutamatergic terminals differentially influence the organization of GABAergic synapses in rat cerebellar granule cells in vitro.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cerebellar Cortex; Fluorescent Antibody Technique; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Presynaptic Terminals; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes; Synaptic Transmission; Vesicular Glutamate Transport Protein 1; Vesicular Transport Proteins | 2002 |
Gamma-aminobutyric acid-induced calcium signalling in rat superior collicular neurones.
Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Cytarabine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Neurons; Phosphinic Acids; Pyridines; Rats; Receptors, GABA; Superior Colliculi | 2002 |
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Body Temperature Regulation; Electroencephalography; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Isoxazoles; Lateral Ventricles; Male; Muscimol; Nipecotic Acids; Preoptic Area; Rabbits; Receptors, GABA-A; Receptors, GABA-B; Rectum; Somatosensory Cortex | 2004 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Blotting, Western; Cell Separation; Electrophysiology; Estradiol; Female; GABA Agonists; GABA Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Isoxazoles; Lanthanum; Lorazepam; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Steroids | 2005 |
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Azides; Benzodiazepines; Bicuculline; Blotting, Western; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Humans; Immunohistochemistry; Immunoprecipitation; In Vitro Techniques; Indoles; Isoxazoles; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Patch-Clamp Techniques; Prokaryotic Initiation Factors; Protein Subunits; Pyridines; Receptors, GABA-A; Synapses; Synaptophysin; Transfection; Ventral Thalamic Nuclei; Zinc Compounds; Zolpidem | 2005 |
Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Morphine; Muscimol; Narcotics; Neurons; Nociceptors; Pain Measurement; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time | 2006 |
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
Topics: Animals; Bicuculline; Electrophysiology; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Medulla Oblongata; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Synapses | 2007 |
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem | 2008 |
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Electrodes, Implanted; Electroencephalography; GABA Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep | 2008 |
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Agonists; GABA Antagonists; Glycine Agents; In Vitro Techniques; Isoxazoles; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neural Inhibition; Patch-Clamp Techniques; Receptors, GABA-A; Strychnine; Thalamus; Time Factors | 2009 |
Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction.
Topics: Action Potentials; Animals; Antioxidants; Bicuculline; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; Glucose; Glutamic Acid; In Vitro Techniques; Isoxazoles; Male; Neurons; Nitro Compounds; Propionates; Rats; Rats, Wistar; Rotenone; Uncoupling Agents; Zonisamide | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.
Topics: Action Potentials; Analgesics; Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Formaldehyde; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hindlimb Suspension; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Pain Measurement; Psychomotor Performance; Receptors, GABA-A; Sensory Receptor Cells; Spinal Cord | 2011 |
Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Sodium Channel Blockers; Solitary Nucleus; Tetrodotoxin | 2012 |
Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons.
Topics: Animals; Bicuculline; Blotting, Western; Cells, Cultured; Crotonates; Electrophysiological Phenomena; GABA Agonists; GABA Antagonists; Ganglia, Spinal; Isoxazoles; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Time Factors; Up-Regulation | 2012 |
The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Drug Synergism; Female; In Vitro Techniques; Ion Channel Gating; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley | 2013 |
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation | 2014 |
Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING.
Topics: Animals; Bicuculline; GABA Agonists; GABAergic Neurons; Humans; Isoxazoles; Locus Coeruleus; Methyl-CpG-Binding Protein 2; Mice; Mice, Transgenic; Receptors, GABA; Receptors, GABA-A; Respiration; Rett Syndrome; Single-Cell Analysis; Synapses | 2015 |
Regulation of Extrasynaptic GABAA α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Activators; Ethanol; Female; GABA Antagonists; Isoxazoles; Male; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses | 2016 |
Perinatal high fat diet increases inhibition of dorsal motor nucleus of the vagus neurons regulating gastric functions.
Topics: Animals; Bicuculline; Brain Stem; Diet, High-Fat; GABA Agonists; GABA Antagonists; Gastrointestinal Motility; Isoxazoles; Male; Neural Inhibition; Neurons; Pyridazines; Rats, Sprague-Dawley; Vagus Nerve | 2018 |