isothiuronium has been researched along with s-methylisothiopseudouronium in 183 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.73) | 18.7374 |
| 1990's | 43 (23.50) | 18.2507 |
| 2000's | 86 (46.99) | 29.6817 |
| 2010's | 49 (26.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Natelson, S | 1 |
| Kim, S; Paik, MK; Paik, WK | 1 |
| Southan, GJ; Szabó, C; Thiemermann, C | 1 |
| Bing, RJ; Dudek, RR; Suzuki, H; Wildhirt, SM | 1 |
| Barbul, A; Gross, SS; Schaffer, MR; Tantry, U; Wasserburg, HL | 1 |
| Akiyama, K; Bing, RJ; Cannavino, C; Grant, P; Horstman, D; Suzuki, H; Wolf, WP | 1 |
| Fici, GJ; Sethy, VH; Stratman, NC | 1 |
| Arkovitz, MS; Garcia, VF; Szabó, C; Wispé, JR | 1 |
| Dudek, R; Horstman, D; Reichart, B; Suzuki, H; Weismueller, S; Wildhirt, SM; Wolf, WP | 1 |
| Currie, MG; McCarthy, TJ; Moore, WM; Welch, MJ; Zhang, J | 1 |
| Boeckxstaens, GE; De Man, JG; De Winter, BY; Herman, AG; Moreels, TG; Pelckmans, PA | 1 |
| Ao, L; Banerjee, A; Brown, JM; Fullerton, DA; Harken, AH; Meng, X | 1 |
| Fukaya, C; Goto, T; Kondo, T; Murakami, K; Sakashita, H; Sugiura, M | 1 |
| Chen, D; Liu, D; Qiu, H | 1 |
| Carnuccio, R; D'Acquisto, F; Herman, AG; Iuvone, T; Van Osselaer, N | 1 |
| Dowsing, B; Guida, E; Hickey, MJ; Knight, KR; Morrison, WA; Phan, LH; Stewart, AG; Zhang, B | 1 |
| Akiyama, K; Dudek, RR; Horstman, D; Reichart, B; Suzuki, H; Weismüller, S; Wildhirt, SM | 1 |
| Gonzalez-Crussi, F; Hsueh, W; Qu, XW; Sun, XM; Tan, XD | 1 |
| Gouw, AS; Havinga, R; Huitema, S; Jansen, PL; Klok, PA; Kuipers, F; Moshage, H; Roelofsen, H; van Goor, H; Vos, TA | 1 |
| Dick, JM; Lefebvre, RA | 1 |
| Bazzani, C; Bertolini, A; Guarini, S | 1 |
| Bolli, R; Guo, Y; Jadoon, AK; Manchikalapudi, S; Qiu, Y; Takano, H; Tang, XL; Zhang, Q | 1 |
| Balogh, Z; Kaszaki, J; Nagy, S; Szabó, C; Wolfárd, A | 1 |
| Feihl, F; Gnaegi, A; Liaudet, L; Markert, M; Perret, C; Rosselet, A | 1 |
| Inoue, S; Kaneko, T; Miyashita, A; Miyazawa, N; Nagashima, Y; Numata, M; Okubo, T; Suzuki, S | 1 |
| Bredt, DS; Comtois, A; El Dwairi, Q; Greenwood, MT; Guo, Y; Hussain, SN; Zhu, E | 1 |
| Lloyd, DM; Parrott, RF; Vellucci, SV | 1 |
| Cross, AH; McCarthy, TJ; Welch, MJ; Zhang, J | 1 |
| Bauer, M; Clemens, MG; Geiger, KK; Hole, B; Köhler, N; Pannen, BH | 1 |
| McDonough, KH; Patel, K; Quinn, M; Smith, T | 1 |
| Chen, JS; Chen, LW; Chen, SC; Hsu, CM; Wang, JS | 1 |
| Bazzani, C; Bertolini, A; Bini, A; Cainazzo, MM; Guarini, S; Meletti, E; Tomasi, A | 1 |
| Cha, MC; Chen, JS; Chen, LW; Chen, SC; Hsu, CM | 1 |
| Brady, KG; Drumm, ML; Elmer, HL; Kelley, TJ | 1 |
| Carretero, OA; LaPointe, MC; Liu, YH; Wang, D; Yang, XP | 1 |
| Hess, ML; Jarrett, NC; Kukreja, RC; Xi, L | 1 |
| Fiscus, RR; Lu, LF | 2 |
| Balogh, Z; Boros, M; Kaszaki, J; Nagy, S; Szabó, C; Wolfárd, A | 1 |
| Chen, DC; Liu, DW; Ma, S; Pan, JQ; Qiu, HB | 1 |
| Broussard, M; Easington, CR; Hollenberg, SM; Osman, J; Parrillo, JE | 1 |
| Hasegawa, T; Iwase, M; Kitaichi, K; Nadai, M; Shibata, E; Takagi, K; Wang, L | 1 |
| Goldbach, J; Roth, J; Störr, B; Voigt, K; Zeisberger, E | 1 |
| Baracos, VE; Bussière, FI; Cynober, LA; Farges, MC; Field, CJ; Le Boucher, J; Robinson, LE | 1 |
| Jarrett, NC; Kukreja, RC; Salloum, F; Tekin, D; Xi, L | 1 |
| Hirata, Y; Imai, T; Masaki, Y; Mitaka, C; Takei, T; Yokoyama, K | 1 |
| Chen, LW; Hsu, CM; Liu, CH | 1 |
| Chelliah, J; Kukreja, RC; Levasseur, JE; Xi, L; Zhao, T | 1 |
| Cohen, RI; Davis, A; Loona, R; Scharf, SM; Shapir, Y | 1 |
| Kukreja, RC; Xi, L | 1 |
| Maeta, H; Mizoguchi, K; Oe, M; Wang, Y; Xu, H | 1 |
| Hunter, K; Larson, DF; Sanders, DB | 1 |
| Chen, HL; Chen, JS; Chen, LW; Hsu, CM; Wang, JS | 1 |
| Cai, B; Cai, KR; Feng, YH; Sun, H; Zheng, HZ | 1 |
| Cubeddu, LX; Malave, A; Xu, X | 1 |
| Barbul, A; Efron, DT; Most, D; Shi, HP; Tantry, US | 1 |
| Keramidaris, E; Morrison, WA; Stewart, AG; Vadiveloo, PK | 1 |
| Ito, H; Suzuki, T; Takemori, K | 1 |
| Koike, M; Kominami, E; Nakanishi, H; Nishioku, T; Okamoto, Y; Peters, C; Saftig, P; Uchiyama, Y; von Figura, K; Yamamoto, K; Zhang, J | 1 |
| Chan, JY; Chan, SH; Wang, LL; Wu, KL | 2 |
| Basustaoglu, A; Comert, B; Deveci, S; Kocabalkan, F; Mas, MR; Ozyurt, M; Refik, M; Saglamkaya, U; Simsek, I; Yasar, M | 1 |
| Kaneko, H; Kuwano, H; Morikawa, H; Tabata, M; Takahashi, A; Tomomasa, T; Tsuchida, Y; Watanabe, T | 1 |
| Qureshi, N; Soeurt, N; Splitter, G; Wang, M | 1 |
| Cohen, RI; Hassell, AM; Liu, SF; Marini, C; Marzouk, K; Scharf, SM | 1 |
| Caldefie, F; Chassagne, J; Cynober, L; Moinard, C; Tridon, A; Vasson, MP; Walrand, S | 1 |
| Jin, D; Liu, X; Sun, W; Wang, J | 1 |
| Chen, LW; Hsu, CM; Liu, CH; Wang, JS | 1 |
| Cobben, DC; Deutz, NE; Hallemeesch, MM; Soeters, PB | 1 |
| Fahas, L; Giaid, A; Hu, F; Saito, T; Shennib, H; Tayara, L | 1 |
| Bock, NA; Davis, WL; Kalisch, BE; Rylett, RJ | 1 |
| Bache, RJ; Chen, Y; Du, R; Hou, M; Traverse, JH | 1 |
| Hasui, M; Kobayashi, Y; Taniuchi, S; Tsuji, S; Yamamoto, A | 1 |
| Hara, K; Honda, T; Horinaka, S; Kobayashi, N; Kobayashi, T; Matsuoka, H; Mita, S; Nishikimi, T; Yoshida, K | 1 |
| Akay, C; Aydogan, H; Comert, B; Deveci, S; Kocar, IH; Mas, MR; Mas, N; Ozturk, M; Simsek, I; Yasar, M | 1 |
| Chan, JY; Chan, SH; Ou, CC; Wang, LL | 1 |
| Cohen, RI; Hassell, AM; Liu, SF; Marzouk, K; Ye, X | 1 |
| BOULU, R; CAPMALE, M; DELGA, J | 1 |
| BOULU, R; DEBBASCH, G; DELGA, J; SPINHIRNY, P | 1 |
| Chen, JS; Chen, LW; Hsu, CM; Hwang, B; Wang, JS | 1 |
| Bilgic, H; Deveci, S; Korkmaz, A; Oter, S; Ozgurtas, T; Sadir, S; Topal, T | 1 |
| Jin, DD; Liu, XX; Qin, LY; Sun, W; Wang, JX | 1 |
| Kazui, T; Kobayashi, T; Koide, Y; Takeuchi, Y; Uenoyama, S; Yamashita, K | 1 |
| Demeris, CS; Ishak, M; Kalisch, BE; Rylett, RJ | 1 |
| Nayeem, MA | 1 |
| Baba, K; Hasegawa, T; Kitaichi, K; Nadai, M; Nakayama, H; Ohta, M; Takagi, K; Ueyama, J | 1 |
| Krukoff, TL; Xu, Y | 1 |
| Gross, GJ; Hsu, AK; Patel, HH | 1 |
| Larson, DF; Watson, RR; Yang, B | 1 |
| Akkerman, A; Sasson, L; Sofer, S; Tarasiuk, A | 1 |
| Bilgic, H; Korkmaz, A; Oter, S; Oztas, E; Topal, T; Yildirim, I | 1 |
| Jiang, X; Nakajima, Y; Sato, S; Shi, E | 2 |
| Cao, LS; Li, DZ; Liao, YH; Wang, X; Zeng, QT; Zheng, B | 1 |
| Hartshorne, GM; Kennedy, CR; Mitchell, LM | 1 |
| Kita, T; Sato, H; Tanaka, N; Tanaka, T | 1 |
| Altaner, S; Basaran, UN; Eskiocak, S; Ture, M; Yapar, SB | 1 |
| Bhat, AS; Krishna, V; Kumar, D; Prakash, VR; Tandan, SK | 3 |
| Chen, HI; Hsu, YH; Lee, CC; Lin, NT | 1 |
| Chancerelle, Y; De Sousa, M; Dinh-Xuan, AT; Florentin, I; Levacher, M; Mathieu, J; Valenti, LM | 1 |
| Berdeaux, A; Colin, P; Ghaleh, B; Hittinger, L; Lucats, L; Monnet, X; Zini, R | 1 |
| Ivanova, IV; Khromov, OS; Stefanov, OV | 1 |
| Baumgarten, G; Djoufack, C; Dreiner, U; Fink, K; Grohé, C; Hoeft, A; Knowlton, AA; Knuefermann, P; Meyer, R; Schuhmacher, G; Vervölgyi, V; von Rappard, J | 1 |
| Cirillo, C; Cuomo, R; De Filippis, D; Esposito, G; Iuvone, T; Sarnelli, G | 1 |
| Bauer, I; Geiger, KK; Hoetzel, A; Humar, M; Leitz, D; Loop, T; Pannen, BH; Schmidt, R; Tritschler, E | 1 |
| Carnuccio, R; De Filippis, D; De Stefano, D; Esposito, G; Iuvone, T; Maiuri, MC | 1 |
| Dragunow, M; Gibbons, HM | 1 |
| Adameová, A; Bukovský, M; Dubnicková, M; Kuzelová, M; Mladonická, M; Svec, P | 1 |
| Deguchi, Y; Fukuda, M; Imamura, Y; Miyoshi, N; Nakagawa, T; Soga, Y; Suga, H; Suzuki, T | 1 |
| Bopp, Ch; Gries, A; Gust, R; Klein, A; Martin, E; Taut, F | 1 |
| Chen, HI; Su, CF; Yang, FL | 1 |
| Cappelletti, G; Galbiati, M; Maggioni, MG; Onesto, E; Poletti, A; Ronchi, C | 1 |
| Cutini, GJ; Paigel, AS; Pinto, VD; Sartório, CL; Stefanon, I; Vassallo, DV | 1 |
| Cheng, SM; Hu, ZY; Zhu, QX | 1 |
| Broshears, WC; Liu, X; Reilly, JP | 1 |
| Bian, CR; Li, DR | 1 |
| Andotra, SS; Bhushan, S; Kaur, IP; Kumar, A; Malik, F; Qazi, GN; Sethi, VK; Singh, J; Taneja, SC | 1 |
| Baumgarten, G; Ehrentraut, S; Fandrey, J; Frede, S; Grohé, C; Mengden, T; Meyer, R; Stapel, H | 1 |
| Andoh, T; Ito, S; Kuraishi, Y; Mabuchi, T; Sasaki, A; Serizawa, K; Shiraki, K; Takasaki, I | 1 |
| Bertuglia, S | 1 |
| Kaushal, V; Schlichter, LC | 1 |
| Fung, ML; Lau, TY; Leung, TM; Liong, EC; Nanji, AA; Tipoe, GL | 2 |
| Chen, HI; Hsu, BG; Hsu, YH | 1 |
| Chongthammakun, S; Govitrapong, P; Tocharus, J | 1 |
| Aksu, B; Aktas, C; Basaran, UN; Guzel, A; Kanter, M; Karasalihoglu, S; Yalcin, O | 1 |
| Akgul, O; Cermik, H; Gundogdu, G; Guven, A; Korkmaz, A; Ozturk, H; Surer, I; Uysal, B | 1 |
| Chan, JY; Hsu, C; Wu, KL | 1 |
| Cai, T; Chen, J; Chen, Y; Huang, C; Liu, M; Luo, W; Wang, Q; Zhao, F; Zheng, G | 1 |
| Chan, JY; Liu, YC; Tsai, YC | 1 |
| Deng, XM; Ni, X; Peng, J; Su, DF; Wang, LG; Wang, WZ; Wang, YK; Yuan, WJ | 1 |
| Lazuko, SS; Maĭorova, SS; Solodkov, AP | 1 |
| Barcos, M; Corrales, FJ; Espejo, I; López-Sánchez, LM; Muñoz-Castañeda, JR; Rodríguez-Ariza, A | 1 |
| ArunaDevi, R; Jaganathan, S; Kumar, D; Kumar, S; Ramteke, VD; Sharma, AK; Shukla, MK; Tandan, SK | 1 |
| Atabek, C; Demirin, H; Karaoglu, A; Kesik, V; Korkmaz, A; Kul, M; Ozler, M; Oztas, E; Sadir, S; Temiz, A; Tunc, T | 1 |
| Dias-Junior, CA; Montenegro, MF; Neto-Neves, EM; Tanus-Santos, JE | 1 |
| Dong, JH; Guo, YJ; Li, W; Li, XF; Mei, YW; Zhang, SL; Zhao, L; Zhou, Y | 1 |
| Gerbut, KA; Kochetygov, NI; Remizova, MI | 1 |
| Cayci, T; Cekli, Y; Kaldirim, U; Korkmaz, A; Oter, S; Ozler, M; Oztas, Y; Poyrazoglu, Y; Sadir, S; Topal, T; Uysal, B; Yasar, M | 1 |
| Chen, IC; Chen, LC; Chiu, YC; Ho, IC; Lou, YJ; Shen, YC; Yen, DH; Yen, JC | 1 |
| Aslan, M; Batinic-Haberle, I; Cort, A; Dogan, S; Ozturk, N; Spasojevic, I; Unal, M; Yargicoglu, P | 1 |
| Doherty, GH; Gaynor, S; Oldreive, CE | 1 |
| Castaño, A; García-Cuervo, L; Jiménez, S; Pintado, C; Revilla, E; Ruano, D; Vitorica, J; Vizuete, ML | 1 |
| Petrović, N; Radenković, M; Roganović, J; Stojić, D; Tanić, N | 1 |
| Liu, Y; Nie, X; Qiu, Z; Shi, S; Song, S; Yao, L; Zhang, L; Zhu, D | 1 |
| Ikunaka, M; Nishimura, Y; Ohyama, Y; Okamoto, Y | 1 |
| Akgul, EO; Aydin, I; Cakir, E; Cayci, T; Isbilir, S; Kenar, L; Korkmaz, A; Kunak, ZI; Kurt, YG; Macit, E; Ozcan, A; Turker, T; Uysal, B; Yaman, H; Yaren, H | 1 |
| Dong, C; He, M; Ren, R; Shao, C; Xie, Y; Ye, S; Yuan, D | 1 |
| Alaçam, H; Gacar, A; Günaydin, M; Güvenç, T; Güzel, A; Murat, N; Saliş, O; Sükrü Paksu, M | 1 |
| He, LS; Lee, OO; Matsumura, K; Qian, PY; Xu, Y; Zhang, G; Zhang, Y | 1 |
| Dhayagude, RS; Gupta, G; Kathirvel, K; Kumar, D; Kumari, RR; Lonare, MK; More, AS; Sharma, AK; Tandan, SK | 1 |
| Chen, LW; Chen, PH; Hsu, CM; Lin, CT; Tsay, TB; Yang, MC | 1 |
| Almeida, RM; Firmino, MA; Oliveira, PG; Ribeiro, PR; Silva, SM; Sousa, JB | 1 |
| Balaganur, V; Gupta, G; Kumar, D; Kumari, RR; Lingaraju, MC; More, AS; Pathak, NN; Sharma, AK; Tandan, SK | 1 |
| Abdul-Careem, MF; Czub, M; Haddadi, S; Jasmine, H; Kim, DS; van der Meer, F | 1 |
| Aydin, I; Kenar, L; Korkmaz, A; Kunak, ZI; Macit, E; Onguru, O; Turel, S; Uysal, B; Yaman, H; Yaren, H | 1 |
| Balaganur, V; Kumar, D; Kumari, RR; Latief, N; Lingaraju, MC; More, AS; Pathak, NN; Tandan, SK | 1 |
| Fu, J; He, M; Jin, W; Li, J; Liu, W; Shao, C; Xiao, L; Xie, Y | 1 |
| Jiang, Q; Song, L; Sun, Z; Wang, L; Wang, M; Yi, Q; Zhou, Z | 1 |
| Beliaeva, LE; Lazuko, SS; Solodkov, AP | 1 |
| Fan, J; Gao, H; Gong, Z; Han, Y; Jiang, Q; Wang, C; Wang, Z; Zheng, Y; Zhong, F | 1 |
| Deng, C; Feng, YQ; Hu, CH; Liu, OS; Liu, XL; Tang, ZG; Wang, JJ; Wu, F; Zhang, HX | 1 |
| Knyazev, EN; Krainova, NA; Lazuko, SS; Nechaev, IN; Solodkov, AP | 1 |
| Iatskovskaia, NM; Solodkov, AP | 1 |
| Prostran, MS; Savic Vujovic, KR; Srebro, DP; Vucković, SM | 1 |
| Dobson, J; Kalisch, BE; Reilly, K; Strachan-Whaley, MR | 1 |
| Alacam, H; Duran, L; Gunaydin, M; Guzel, A; Kayhan, S; Murat, N; Selcuk, MY; Torun, AC; Tutuncu, S; Yilmaz, MZ | 1 |
| Lishmanov, YB; Maslov, LN; Naryzhnaya, NV; Prokudina, ES; Tsibulnikov, SY | 1 |
| Ding, J; Wang, J; Zhang, W; Zheng, L; Zhou, C | 1 |
| Han, Z; Liu, LL; Liu, QA; Qian, PY; Shao, CL; Sun, J; Wang, CY; Wang, KL; Xu, Y; Zhang, G | 1 |
| Bagci, S; Beyzadeoglu, M; Caliskan, B; Demirci, H; Ergun, H; Kadayifci, A; Karslioglu, Y; Ozel, M; Ozler, M; Ozturk, O; Oztutk, K; Polat, Z; Sager, O; Sahiner, F; Uygun, A | 1 |
| Ahn, YE; Harris, RA; Jang, JE; Kim, AR; Kim, BJ; Kim, HJ; Kim, JH; Kim, MO; Ko, MS; Koh, EH; Lee, KU; Lee, WJ; Oh, JS; Park, HS; Yun, JY | 1 |
| Chan, SH; Chang, AY; Cheng, CD; Poon, YY; Tsai, CY | 1 |
| Prostran, M; Srebro, D; Vučković, S | 1 |
| Amorim, EDT; Barbosa, DS; Castardo-de-Paula, JC; da Silva, RV; de Campos, BH; de Farias, CC; Higachi, L; Martins-Pinge, MC; Pinge-Filho, P | 1 |
| Ahlawat, A; Sharma, S | 1 |
| Milovanović, A; Prostran, M; Srebro, DP; Vučetić, Č; Vučković, S; Vujović, KS | 1 |
| Belyaeva, LE; Lazuko, SS; Manuchina, EB | 1 |
| Gajbhiye, DS; Khandeparker, L | 1 |
| Liang, B; Su, J | 1 |
2 review(s) available for isothiuronium and s-methylisothiopseudouronium
| Article | Year |
|---|---|
Involvement of inducible nitric oxide synthase in the inflammatory process of myocardial infarction.
Topics: Animals; Apoptosis; Coronary Circulation; Enzyme Induction; Enzyme Inhibitors; Humans; Immunohistochemistry; Inflammation; Isothiuronium; Macrophages; Myocardial Infarction; Myocardium; Nitric Oxide Synthase; Rabbits; Ventricular Function, Left | 1995 |
Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction.
Topics: Adjuvants, Immunologic; Animals; Enzyme Inhibitors; Glycolipids; Humans; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Isothiuronium; Lipid A; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Perfusion; Rats; Signal Transduction | 2000 |
181 other study(ies) available for isothiuronium and s-methylisothiopseudouronium
| Article | Year |
|---|---|
The lactam of alpha-guanidinoglutaric acid (1-amidino-2-pyrrolidone-5-carboxylic acid).
Topics: Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Glutarates; Isothiuronium; Magnetic Resonance Spectroscopy; Optical Rotation; Picrates; Pyrrolidinones; Spectrophotometry, Infrared | 1986 |
delta-N-[methyl-14C]Arginine: a simplified preparation.
Topics: Arginine; Isothiuronium; Ornithine | 1980 |
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Cells, Cultured; Endothelium, Vascular; Enzyme Induction; Escherichia coli; Hemodynamics; In Vitro Techniques; Isothiuronium; Macrophages; Male; Mice; Nitric Oxide Synthase; Rats; Rats, Wistar; Shock, Septic | 1994 |
Nitric oxide regulates wound healing.
Topics: Animals; Collagen; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxyproline; Infusions, Parenteral; Isothiuronium; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Wound Healing; Wounds and Injuries | 1996 |
Effect of inhibitors of inducible form of nitric oxide synthase in infarcted heart muscle.
Topics: Animals; Arginine; Cyclosporine; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Heart; Isothiuronium; Male; Myocardial Infarction; Myocardium; Nitric Oxide Synthase; Nitroarginine; Rabbits | 1996 |
U-19451A: a selective inducible nitric oxide synthase inhibitor.
Topics: Animals; Arginine; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Escherichia coli; Isoenzymes; Isothiuronium; Lipopolysaccharides; Lung; Male; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Thiourea | 1996 |
Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Enzyme Inhibitors; Extravascular Lung Water; Guanidines; Isothiuronium; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome | 1996 |
S-methylisothiourea inhibits inducible nitric oxide synthase and improves left ventricular performance after acute myocardial infarction.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Enzyme Induction; Enzyme Inhibitors; Heart Rate; Heart Ventricles; Isoenzymes; Isothiuronium; Male; Myocardial Infarction; Myocardium; Nitric Oxide Synthase; Nitroarginine; Rabbits; Vascular Resistance; Ventricular Function, Left | 1996 |
Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.
Topics: Animals; Carbon Isotopes; Female; Fluorine; Half-Life; Isothiuronium; Magnetic Resonance Spectroscopy; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Fast Atom Bombardment; Thiourea; Tissue Distribution; Tomography, Emission-Computed | 1996 |
Effect of adrenergic and nitrergic blockade on experimental ileus in rats.
Topics: Adrenergic Antagonists; Adrenergic Uptake Inhibitors; Anesthesia, General; Animals; Arginine; Autonomic Pathways; Enzyme Inhibitors; Gastrointestinal Transit; Guanidines; Intestinal Obstruction; Isothiuronium; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Reserpine | 1997 |
Nitric oxide synthase is not involved in cardiac contractile dysfunction in a rat model of endotoxemia without shock.
Topics: Animals; Arginine; Blood Pressure; Dexamethasone; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Isothiuronium; Myocardial Contraction; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1997 |
Novel histamine H3 receptor antagonists: synthesis and evaluation of formamidine and S-methylisothiourea derivatives.
Topics: Amidines; Animals; Cerebral Cortex; Guinea Pigs; Histamine Antagonists; Isothiuronium; Piperidines; Rats; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3 | 1997 |
[Effects of selective nitric oxide synthase inhibitor in sheep with endotoxic shock].
Topics: Animals; Blood Pressure; Hemodynamics; Isothiuronium; Nitric Oxide Synthase; Oxygen Consumption; Random Allocation; Sheep; Shock, Septic | 1996 |
Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat.
Topics: Animals; Arginine; Capillary Permeability; Carrageenan; Cell Movement; Enzyme Inhibitors; Epoprostenol; Inflammation; Isothiuronium; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 1997 |
Timing of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; DNA Probes; Enzyme Inhibitors; Indazoles; Isothiuronium; Male; Muscle, Skeletal; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Ornithine; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors | 1997 |
Selective modulation of inducible nitric oxide synthase isozyme in myocardial infarction.
Topics: Animals; Coronary Circulation; Cyclic GMP; Enzyme Induction; Enzyme Inhibitors; Hemodynamics; Isothiuronium; Male; Myocardial Infarction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rabbits; Ventricular Function, Left | 1997 |
Injurious and protective mechanisms in the gut. Interaction of PAF, phospholipase A2, eicosanoids, and nitric oxide synthase.
Topics: Animals; Eicosanoids; Enzyme Activation; Enzyme Inhibitors; Group II Phospholipases A2; Guanidines; Inflammation; Intestinal Mucosa; Isothiuronium; Leukotriene C4; Male; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1997 |
Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats.
Topics: Amino Acid Sequence; Animals; Antibodies; Bile; Bile Canaliculi; Bile Ducts; Endotoxemia; Endotoxins; Enzyme Inhibitors; Epithelium; Escherichia coli; Hemodynamics; Immunohistochemistry; Inflammation; Isothiuronium; Lipopolysaccharides; Liver; Macrophages; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
Topics: Animals; Biotin; Citrulline; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Isothiuronium; Lysine; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Swine; Thiourea | 1997 |
Inhibition of nitric oxide synthases enhances the effect of ACTH in hemorrhagic shock.
Topics: Animals; Arginine; Cosyntropin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Shock, Hemorrhagic | 1997 |
The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning.
Topics: Animals; Guanidines; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Myocardial Stunning; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rabbits | 1997 |
Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.
Topics: Animals; beta-Aminoethyl Isothiourea; Blood Circulation; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Endotoxemia; Endotoxins; Enzyme Inhibitors; Escherichia coli; Escherichia coli Infections; Hemodynamics; Isothiuronium; Myocardial Contraction; Nitric Oxide Synthase; Nitroarginine; Ventricular Function, Left; Ventricular Pressure | 1997 |
Selective iNOS inhibition is superior to norepinephrine in the treatment of rat endotoxic shock.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hemodynamics; Infusions, Intravenous; Isothiuronium; Lipopolysaccharides; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Vasoconstrictor Agents | 1998 |
Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs.
Topics: Animals; Dogs; Enzyme Inhibitors; Guanidines; Hemodynamics; Isothiuronium; Lipopolysaccharides; Lung; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Gas Exchange; Respiratory Distress Syndrome; Tyrosine | 1998 |
Ontogenesis of nitric oxide synthases in the ventilatory muscles.
Topics: Aging; Animals; Argininosuccinate Lyase; Argininosuccinate Synthase; Diaphragm; Female; Gene Expression Regulation; Immunoblotting; Immunohistochemistry; Isothiuronium; Male; Muscle Development; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transcription, Genetic | 1998 |
Effects of intravenous nitric oxide inhibitors on endotoxin-induced fever in prepubertal pigs.
Topics: Animals; Endotoxins; Enzyme Inhibitors; Fever; Guanidines; Isothiuronium; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Swine | 1998 |
Measurement of upregulation of inducible nitric oxide synthase in the experimental autoimmune encephalomyelitis model using a positron emitting radiopharmaceutical.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Isothiuronium; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiopharmaceuticals; Tomography, Emission-Computed; Up-Regulation | 1997 |
Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.
Topics: Animals; Bile; Carbon Monoxide; Heme Oxygenase (Decyclizing); Hemodynamics; In Vitro Techniques; Ischemia; Isothiuronium; Liver; Male; Metalloporphyrins; Microcirculation; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Perfusion; Protoporphyrins; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic | 1998 |
Myocardial dysfunction in the septic rat heart: role of nitric oxide.
Topics: Animals; Coronary Circulation; Dexamethasone; Escherichia coli Infections; In Vitro Techniques; Isothiuronium; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Perfusion; Rats; Rats, Sprague-Dawley; Sepsis; Ventricular Function, Left | 1998 |
Specific inhibition of iNOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury.
Topics: Animals; Antioxidants; Bacterial Translocation; Body Surface Area; Burns; Coloring Agents; Enzyme Inhibitors; Female; Intestinal Mucosa; Intestine, Small; Isothiuronium; Liver; Lymph Nodes; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Rats; Rats, Sprague-Dawley; Spleen; Superoxides; Tyrosine | 1998 |
High blood levels of nitric oxide in rats subjected to prolonged respiratory arrest and their modulation during adrenocorticotropin-induced resuscitation.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Cardiopulmonary Resuscitation; Electrocardiography; Electron Spin Resonance Spectroscopy; Electrooculography; Enzyme Inhibitors; Female; Heart Rate; Hemoglobins; Isothiuronium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Respiration, Artificial; Respiratory Insufficiency | 1999 |
Changes in gut mucosal nitric oxide synthase (NOS) activity after thermal injury and its relation with barrier failure.
Topics: Animals; Bacterial Translocation; Burns; Digestive System; Enzyme Inhibitors; Female; Intestinal Absorption; Intestinal Mucosa; Isothiuronium; Nitric Oxide Synthase; Permeability; Rats; Rats, Sprague-Dawley | 1999 |
Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium.
Topics: Animals; Biological Transport; Chlorides; Dexamethasone; Enzyme Inhibitors; Glucocorticoids; Ions; Isothiuronium; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Nasal Mucosa; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sodium | 1999 |
Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase.
Topics: Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cell Death; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Follow-Up Studies; Guanidines; Heart; Interleukin-1; Isothiuronium; Male; Myocardial Infarction; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1999 |
Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice.
Topics: Animals; Body Weight; Cardiotonic Agents; Coronary Circulation; Enzyme Inhibitors; Heart Rate; Hemodynamics; In Vitro Techniques; Isothiuronium; Lipid A; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Size; Ventricular Function | 1999 |
Interleukin-1beta causes different levels of nitric oxide-mediated depression of contractility in different positions of rat thoracic aorta.
Topics: Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; Interleukin-1; Isothiuronium; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 1999 |
Effects of selective nitric oxide synthase inhibition in hyperdynamic endotoxemia in dogs.
Topics: Animals; Biopsy; Dogs; Endotoxemia; Endotoxins; Enzyme Inhibitors; Escherichia coli; Heart; Hemodynamics; Isothiuronium; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 1999 |
Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages.
Topics: Animals; Enzyme Inhibitors; Interleukin-1; Interleukin-10; Interleukin-6; Isothiuronium; Lipopolysaccharides; Macrophages, Alveolar; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Recombinant Proteins; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1999 |
Effects of nitric oxide synthase inhibition on microvascular reactivity in septic mice.
Topics: Animals; Drug Evaluation, Preclinical; Enzyme Inhibitors; Isothiuronium; Male; Mice; Mice, Inbred BALB C; Microcirculation; Microscopy, Video; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; omega-N-Methylarginine; Sepsis | 1999 |
Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Inhibitors; Isothiuronium; Klebsiella pneumoniae; Liver; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitro Compounds; Rats; Rats, Wistar | 1999 |
Dose-dependent attenuation of lipopolysaccharide-fever by inhibitors of inducible nitric oxide-synthase in guinea pigs.
Topics: Animals; Body Temperature; Cytokines; Dose-Response Relationship, Drug; Endotoxins; Enzyme Inhibitors; Escherichia coli; Feedback; Fever; Guanidines; Guinea Pigs; Interleukin-6; Isothiuronium; Lipopolysaccharides; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tumor Necrosis Factor-alpha | 1999 |
Amino acid nutrition and immune function in tumour-bearing rats: a comparison of glutamine-, arginine- and ornithine 2-oxoglutarate-supplemented diets.
Topics: Analysis of Variance; Animals; Arginine; Cytokines; Cytotoxicity Tests, Immunologic; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; Glutamine; Interferon-gamma; Isothiuronium; Killer Cells, Natural; Liver Neoplasms, Experimental; Lymphocyte Activation; Macrophages, Peritoneal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Ornithine; Rats; Rats, Inbred BUF; Receptors, Interleukin-2; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1999 |
Glycolipid RC-552 induces delayed preconditioning-like effect via iNOS-dependent pathway in mice.
Topics: Animals; Cardiotonic Agents; Enzyme Inhibitors; Glycolipids; Hemodynamics; Ischemic Preconditioning; Isothiuronium; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 1999 |
Calcitonin gene-related peptide causes long-term inhibition of contraction in rat thoracic aorta through a nitric oxide-dependent pathway.
Topics: Animals; Aorta, Thoracic; Calcitonin Gene-Related Peptide; Drug Interactions; Enzyme Inhibitors; In Vitro Techniques; Interleukin-1; Isothiuronium; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Phenylephrine; Rats; Rats, Sprague-Dawley | 1999 |
S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; Enzyme Inhibitors; Hemodynamics; Isothiuronium; Kidney; Lipopolysaccharides; Liver; Male; Multiple Organ Failure; Nitric Oxide Synthase; Shock, Septic | 2000 |
Nitric oxide synthase inhibitor ameliorates oral total parenteral nutrition-induced barrier dysfunction.
Topics: Administration, Oral; Animals; Atrophy; Bacterial Translocation; Dextrans; Enzyme Activation; Enzyme Inhibitors; Female; Fluorescein-5-isothiocyanate; Ileum; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Isothiuronium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parenteral Nutrition, Total; Permeability; Rats; Rats, Sprague-Dawley; Solutions | 2000 |
Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.
Topics: Adenosine; Animals; Enzyme Inhibitors; Female; Heart; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Ventricular Function, Left | 2000 |
Comparison between selective and nonselective nitric oxide synthase inhibition and phenylephrine in normal and endotoxic swine.
Topics: Animals; Cardiotonic Agents; Enzyme Inhibitors; Female; Hemodynamics; Isothiuronium; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Shock, Septic; Swine | 2000 |
Intestinal ischemia induces late preconditioning against myocardial infarction: a role for inducible nitric oxide synthase.
Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Guanidines; Intestinal Mucosa; Intestines; Ischemia; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Mesenteric Artery, Superior; Myocardial Ischemia; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley | 2001 |
In vitro comparison of inhibitors of inducible nitric oxide synthase in a macrophage model.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Ethanol; Flow Cytometry; In Vitro Techniques; Isothiuronium; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; United States | 2000 |
Inhibition of inducible nitric oxide synthase (iNOS) prevents lung neutrophil deposition and damage in burned rats.
Topics: Animals; Burns; Enzyme Inhibitors; Female; Isothiuronium; Lung; Lung Injury; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Permeability; Peroxidase; Rats; Rats, Sprague-Dawley; Rhodamines | 2001 |
[Protective effects of SMT on myocardial ultrastructure of ischemia reperfusion injury in heart of rat].
Topics: Animals; Female; Isothiuronium; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2000 |
Expression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated rats.
Topics: Acrolein; Animals; Cells, Cultured; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Hemorrhage; Interferon-gamma; Isothiuronium; Male; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Size; Plasma; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Urinary Bladder | 2001 |
A novel method of studying wound healing.
Topics: Adenoviridae; Animals; Histological Techniques; Hydroxyproline; Injections, Subcutaneous; Isothiuronium; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Polyvinyl Alcohol; Porifera; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Viral; Sodium Chloride; Transcription, Genetic; Wound Healing | 2001 |
Lipopolysaccharide-induced cell cycle arrest in macrophages occurs independently of nitric oxide synthase II induction.
Topics: Animals; Blotting, Western; Cell Cycle; Cells, Cultured; Cyclin D1; Isothiuronium; Lipopolysaccharides; Macrophage Activation; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Knockout; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites | 2001 |
Effects of inducible nitric oxide synthase inhibition on cerebral edema in severe hypertension.
Topics: Animals; Brain Edema; Cerebral Cortex; Fibrinogen; Glial Fibrillary Acidic Protein; Hypertension; Intercellular Adhesion Molecule-1; Isothiuronium; Male; Monosaccharide Transport Proteins; Neutrophils; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke | 2000 |
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.
Topics: Animals; Apoptosis; Body Weight; Cathepsin D; Cell Count; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Intestine, Small; Isothiuronium; Macrophages; Mice; Mice, Knockout; Microglia; Neuronal Ceroid-Lipofuscinoses; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phagocytosis; Thalamus | 2001 |
Reduced functional expression and molecular synthesis of inducible nitric oxide synthase in rostral ventrolateral medulla of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Down-Regulation; Enzyme Inhibitors; Heart Rate; Hypertension; Isothiuronium; Kinetics; Lipopolysaccharides; Male; Medulla Oblongata; Microinjections; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Survival Rate; Transcription, Genetic; Vasomotor System | 2001 |
Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Bacterial Translocation; Cecum; Disease Models, Animal; Enterococcus; Enzyme Inhibitors; Escherichia coli; Isothiuronium; Liver; Lymph Nodes; Male; Mesentery; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Culture Techniques; Pancreas; Pancreatitis; Peritoneum; Rats; Rats, Sprague-Dawley | 2001 |
Intestinal motility in an in vivo rat model of intestinal ischemia-reperfusion with special reference to the effects of nitric oxide on the motility changes.
Topics: Animals; Disease Models, Animal; Duodenum; Enzyme Inhibitors; Gastrointestinal Motility; Isothiuronium; Jejunum; Male; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Reperfusion Injury | 2001 |
High levels of nitric oxide production decrease early but increase late survival of Brucella abortus in macrophages.
Topics: Animals; Apoptosis; Brucella abortus; Brucellosis; Cattle; Cell Line; Colony Count, Microbial; Isothiuronium; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites | 2001 |
Renal effects of nitric oxide in endotoxemia.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Endotoxemia; Female; Glomerular Filtration Rate; Isothiuronium; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen Consumption; Renal Circulation; Resuscitation; Shock, Septic; Swine | 2001 |
Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines.
Topics: Animals; Arginine; Chemotaxis, Leukocyte; Dexamethasone; Eflornithine; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Hydrogen Peroxide; Isothiuronium; Male; Methionine Sulfoximine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Sprague-Dawley; Respiratory Burst; Stress, Psychological | 2002 |
[Long-term effect of nitric oxide synthase inhibitor on repair of articular cartilage defects repairing].
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cartilage, Articular; Disease Models, Animal; Enzyme Inhibitors; Isothiuronium; Joint Diseases; Joints; Male; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Sulfur Radioisotopes | 2002 |
Kupffer cells protect liver from ischemia-reperfusion injury by an inducible nitric oxide synthase-dependent mechanism.
Topics: Animals; Enzyme Inhibitors; Female; Gadolinium; Isothiuronium; Kupffer Cells; Lipid Peroxidation; Liver; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2002 |
Differential effects of selective and non-selective NOS inhibition on renal arginine and protein metabolism during endotoxemia in rats.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Isothiuronium; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Biosynthesis; Proteins; Random Allocation; Rats; Rats, Wistar; Sepsis; Specific Pathogen-Free Organisms | 2002 |
Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure.
Topics: Animals; Blotting, Western; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Failure; Immunohistochemistry; Isothiuronium; Ligation; Male; Myocardial Infarction; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Inbred Lew; Survival Rate; Treatment Outcome | 2002 |
Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells.
Topics: Animals; Choline O-Acetyltransferase; Enzyme Inhibitors; Fluorescent Dyes; Isothiuronium; NADPH Dehydrogenase; Nerve Growth Factor; Neurites; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; PC12 Cells; Rats; RNA, Messenger | 2002 |
Nitric oxide modulates myocardial oxygen consumption in the failing heart.
Topics: Acetylcholine; Animals; Coronary Circulation; Dogs; Enzyme Inhibitors; Heart Failure; Hemodynamics; Isothiuronium; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Oxygen Consumption | 2002 |
Increased nitric oxide production by neutrophils from patients with chronic granulomatous disease on trimethoprim-sulfamethoxazole.
Topics: Adolescent; Adult; Anti-Infective Agents; Calcimycin; Child; Child, Preschool; Enzyme Inhibitors; Fluoresceins; Fluorescence; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Indazoles; Infant; Isothiuronium; Lipopolysaccharides; Male; Neutrophils; Nitric Oxide; Trimethoprim, Sulfamethoxazole Drug Combination | 2002 |
Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Gene Expression; Guanidines; Heart; Heart Failure; Hypertension; Isothiuronium; Male; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred Dahl; RNA, Messenger; Sodium Chloride, Dietary; Stroke Volume; Ventricular Remodeling | 2002 |
The role of inducible nitric oxide synthase inhibitor, meropenem, and taurine in experimental acute necrotizing pancreatitis.
Topics: Animals; Bacteria; Bacterial Translocation; Drug Therapy, Combination; Enzyme Inhibitors; Glutathione Peroxidase; Isothiuronium; Male; Malondialdehyde; Meropenem; Nitric Oxide Synthase; Oxidative Stress; Pancreas; Pancreatitis, Acute Necrotizing; Peritoneum; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Taurine; Taurocholic Acid; Thienamycins | 2003 |
Downregulation of angiotensin subtype 1 receptor in rostral ventrolateral medulla during endotoxemia.
Topics: Animals; Bradycardia; Down-Regulation; Endotoxemia; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Hemodynamics; Hypotension; Isothiuronium; Kinetics; Male; Medulla Oblongata; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Vasomotor System | 2003 |
Lipopolysaccharide down-regulates inducible nitric oxide synthase expression in swine heart in vivo.
Topics: Animals; Coronary Circulation; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Isothiuronium; Lipopolysaccharides; Liver; Liver Circulation; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Swine | 2003 |
[Effect of S-methylisothiourea sulfate on smooth muscle fibers].
Topics: Isothiuronium; Muscle, Smooth; Muscles; Myocytes, Smooth Muscle; Sulfates; Sulfur Oxides; Thiourea | 1958 |
[Pharmacodynamic research on S-methylisothiouronium sulfate].
Topics: Isothiuronium; Research; Sulfates; Thiourea | 1959 |
Reversal of the effect of albumin on gut barrier function in burn by the inhibition of inducible isoform of nitric oxide synthase.
Topics: Albumins; Animals; Bacterial Translocation; Burns; Drug Antagonism; Enzyme Inhibitors; Fluid Therapy; Intestinal Diseases; Intestinal Mucosa; Isothiuronium; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Permeability; Peroxidase; Plasma Substitutes; Rats; Rats, Sprague-Dawley | 2003 |
Involvement of nitric oxide and hyperbaric oxygen in the pathogenesis of cyclophosphamide induced hemorrhagic cystitis in rats.
Topics: Animals; Antineoplastic Agents, Alkylating; Arginine; Cyclophosphamide; Cystitis; Hemorrhage; Hyperbaric Oxygenation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2003 |
Effect of nitric oxide synthase inhibitor on proteoglycan metabolism in repaired articular cartilage in rabbits.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Cartilage Diseases; Cartilage, Articular; Disease Models, Animal; Immunohistochemistry; Isothiuronium; Male; Nitric Oxide Synthase; Probability; Proteoglycans; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity | 2003 |
Improvement of intestinal motility using S-methylisothiourea in postoperative ileus.
Topics: Animals; Dogs; Enzyme Inhibitors; Gastrointestinal Motility; Ileus; Isothiuronium; Postoperative Complications | 2004 |
Modulation of nerve growth factor-induced activation of MAP kinase in PC12 cells by inhibitors of nitric oxide synthase.
Topics: Animals; Blotting, Western; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Isothiuronium; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Time Factors | 2003 |
Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Decanoic Acids; Enzyme Activation; Enzyme Inhibitors; Glyburide; Hydroxy Acids; Ischemic Preconditioning; Isothiuronium; L-Lactate Dehydrogenase; Male; Mice; Myocardial Ischemia; Myocytes, Cardiac; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Protein Kinase C-epsilon; Receptor, Adenosine A1 | 2004 |
Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7.
Topics: Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Down-Regulation; Drug Interactions; Escherichia coli O157; Isothiuronium; Liver; Male; Membrane Proteins; Nitric Oxide; Rats; Rats, Wistar; Shiga Toxin 2; Steroid 16-alpha-Hydroxylase; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA.
Topics: Adrenomedullin; Animals; Area Under Curve; Bicuculline; Blood Pressure; Enzyme Inhibitors; gamma-Aminobutyric Acid; In Situ Hybridization; Indazoles; Intracellular Signaling Peptides and Proteins; Isothiuronium; Male; Membrane Proteins; Models, Biological; NADP; NADPH Dehydrogenase; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Peptides; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Proteins; Sodium; Time Factors | 2004 |
COX-2 and iNOS in opioid-induced delayed cardioprotection in the intact rat.
Topics: Analysis of Variance; Animals; Benzamides; Blood Pressure; Cardiotonic Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Guanidines; Heart Rate; Ischemic Preconditioning, Myocardial; Isoenzymes; Isothiuronium; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sulfonamides | 2004 |
Modulation of iNOS activity in age-related cardiac dysfunction.
Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Guanidines; Isothiuronium; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Ventricular Dysfunction, Left | 2004 |
Effect of venom from the scorpion Leiurus quinquestriatus on rat vascular aortic rings.
Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Drug Synergism; Isothiuronium; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Phenoxybenzamine; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Scorpions; Time Factors; Vasoconstriction; Vasodilation; Verapamil | 2003 |
Inducible nitric oxide synthase inhibition in cyclophosphamide induced hemorrhagic cystitis in rats.
Topics: Animals; Antineoplastic Agents, Alkylating; Arginine; Cyclophosphamide; Cystitis; Disease Models, Animal; Enzyme Inhibitors; Female; Hemorrhage; Isothiuronium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley | 2004 |
Inducible nitric oxide synthase mediates delayed cardioprotection induced by morphine in vivo: evidence from pharmacologic inhibition and gene-knockout mice.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Coronary Vessels; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hemodynamics; Isothiuronium; Male; Mice; Mice, Knockout; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 2004 |
Inhibition of NOS2 ameliorates cardiac remodeling, improves heart function after myocardial infarction in rats.
Topics: Animals; Blotting, Western; Enzyme Inhibitors; Isothiuronium; Ligation; Male; Myocardial Infarction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Ventricular Remodeling | 2004 |
Pharmacological manipulation of nitric oxide levels in mouse follicle cultures demonstrates key role of extrafollicular control of ovulation.
Topics: Animals; Enzyme Inhibitors; Female; Interleukin-1; Isothiuronium; Lipopolysaccharides; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Nitroso Compounds; omega-N-Methylarginine; Organ Culture Techniques; Ovarian Follicle; Ovulation; S-Nitroso-N-Acetylpenicillamine | 2004 |
Involvement of inducible nitric oxide synthase in renal failure after mild hemorrhage.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatine Kinase; Creatinine; Enzyme Inhibitors; Eosinophils; Heart Rate; Hemorrhage; Isothiuronium; Kidney Tubules, Proximal; Male; Microscopy; Neutrophils; Nitric Oxide Synthase; Rats; Rats, Wistar; RNA, Messenger; Urine | 2004 |
[Effect of s-methylthiourea on cholinesterase].
Topics: Blood; Cholinesterases; Humans; Isothiuronium; Thiourea | 1950 |
Inhibition of iNOS with S-methylisothiourea was impaired in wound healing in caustic esophageal burn.
Topics: Animals; Burns, Chemical; Enzyme Inhibitors; Esophagus; Hydroxyproline; Isothiuronium; Male; Nitric Oxide Synthase Type II; Nitroarginine; Rats; Rats, Wistar; Survival Rate; Treatment Outcome; Wound Healing | 2005 |
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study.
Topics: Animals; Body Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fever; Isothiuronium; Lactones; Linear Models; Male; Mefenamic Acid; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Random Allocation; Saccharomyces cerevisiae; Sulfones; Treatment Outcome | 2005 |
Inducible nitric oxide synthase inhibition potentiates multiple organ dysfunction induced by endotoxin in conscious rats.
Topics: Animals; Blood Pressure; Consciousness; Endotoxins; Enzyme Inhibitors; Heart Rate; Isothiuronium; Liver; Lysine; Male; Multiple Organ Failure; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sepsis | 2005 |
High levels of endogenous nitric oxide produced after burn injury in rats arrest activated T lymphocytes in the first G1 phase of the cell cycle and then induce their apoptosis.
Topics: Animals; Apoptosis; Burns; Cell Division; Cell Proliferation; Concanavalin A; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Interleukin-2; Isothiuronium; Lymphocyte Activation; Male; Models, Biological; Necrosis; Nitric Oxide; Rats; Rats, Wistar; Spleen; T-Lymphocytes; Thiazines; Tumor Suppressor Protein p53 | 2005 |
Nitric oxide- and superoxide-dependent mitochondrial signaling in endotoxin-induced apoptosis in the rostral ventrolateral medulla of rats.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Caspase 3; Caspase 9; Caspases; Cyclic N-Oxides; Cytochromes c; Cytosol; DNA; DNA Fragmentation; Endotoxins; Escherichia coli; Isothiuronium; Lipopolysaccharides; Male; Microscopy, Fluorescence; Mitochondria; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nucleosomes; Oxygen; Rats; Rats, Sprague-Dawley; Signal Transduction; Spin Labels; Superoxide Dismutase; Superoxides; Time Factors; Up-Regulation | 2005 |
Phenotypic adaptation of the late preconditioned heart: myocardial oxygen consumption is reduced.
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Dobutamine; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Heart Ventricles; Ischemic Preconditioning, Myocardial; Isothiuronium; Models, Animal; Myocardial Ischemia; Myocardium; Nitric Oxide Synthase Type II; Oxygen Consumption; Stimulation, Chemical; Time Factors; Ventricular Pressure | 2006 |
[Inhibition of nitric oxide synthesis during bacterial shock does not prevent development of resistant hypotension and death in rats].
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Hypotension; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Shock, Septic | 2005 |
COX-2 mediates morphine-induced delayed cardioprotection via an iNOS-dependent mechanism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiotonic Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Heart; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Morphine; Myocardial Infarction; Myocardium; Nitric Oxide Synthase Type II; Nitrobenzenes; Sulfonamides; Up-Regulation | 2006 |
Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia.
Topics: Animals; Cardiomyopathies; Cells, Cultured; Endotoxemia; Enzyme Inhibitors; Gram-Negative Bacterial Infections; Isothiuronium; Lipid A; Lipopolysaccharides; Mice; Myocardial Contraction; Myocardium; Myocytes, Cardiac; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Sarcomeres; Toll-Like Receptor 4 | 2006 |
The astroglial-derived S100beta protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation.
Topics: Animals; Astrocytes; Autoantigens; Biomarkers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Isothiuronium; Lipid Peroxidation; Macrophages, Peritoneal; Mice; Nerve Growth Factors; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; RNA, Messenger; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2006 |
Mechanism of hepatic heme oxygenase-1 induction by isoflurane.
Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; Blotting, Northern; Blotting, Western; Dexamethasone; Ditiocarb; Enzyme Induction; Enzyme Inhibitors; Gadolinium; Heme Oxygenase-1; Immunohistochemistry; Isoflurane; Isothiuronium; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; RNA; Signal Transduction | 2006 |
Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cannabidiol; Humans; Isothiuronium; Neuroprotective Agents; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Fragments; Phosphorylation; Rats | 2006 |
Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide.
Topics: Analysis of Variance; Animals; Cell Communication; Cell Death; Cell Line; Cell Survival; Coculture Techniques; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hypothermia; Immunohistochemistry; Interferon-gamma; Isothiuronium; Lipopolysaccharides; Mice; Microglia; Neuroblastoma; Neurons; Nitric Oxide; Radioimmunoassay; Tetrazolium Salts; Thiazoles | 2006 |
NO-synthase inhibitors provide influence on protective effect of modified endotoxine diphosphoryl lipid A in a rat heart model of ischemic-reperfusion injury.
Topics: Animals; Cardiotonic Agents; Enzyme Inhibitors; In Vitro Techniques; Isothiuronium; Lipid A; Male; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tachycardia | 2006 |
Reinforcement therapy using nitric oxide synthase inhibitors against endotoxin shock in dogs.
Topics: Animals; Catecholamines; Dogs; Endotoxins; Enzyme Inhibitors; Isothiuronium; Models, Animal; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic | 2006 |
Responsiveness to inhaled NO in isolated-perfused lungs from endotoxin-challenged rats is dependent on endogenous nitrite/nitrate synthesis.
Topics: Administration, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guanidines; Isothiuronium; Lipopolysaccharides; Lung; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Perfusion; Rats; Rats, Sprague-Dawley | 2007 |
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study.
Topics: Animals; Arthritis, Experimental; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Interactions; Female; Hindlimb; Isothiuronium; Lactones; Malondialdehyde; Mefenamic Acid; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Rats; Sulfones; Upper Extremity | 2007 |
Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats.
Topics: Animals; Endotoxemia; Endotoxins; Enzyme Inhibitors; Infusions, Intravenous; Interleukin-1beta; Isothiuronium; Lipopolysaccharides; Lung; Lysine; Male; Methylguanidine; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Organ Size; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Tumor Necrosis Factor-alpha | 2007 |
Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells.
Topics: Animals; Cell Differentiation; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; GPI-Linked Proteins; Green Fluorescent Proteins; Isothiuronium; Membrane Proteins; Nerve Growth Factor; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; PC12 Cells; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection; Tyrosine 3-Monooxygenase | 2007 |
Enhanced beta-adrenergic response in rat papillary muscle by inhibition of inducible nitric oxide synthase after myocardial infarction.
Topics: Adrenergic beta-Agonists; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoproterenol; Isothiuronium; Male; Myocardial Contraction; Myocardial Infarction; Nitric Oxide Synthase Type II; Papillary Muscles; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Ventricular Dysfunction, Left | 2007 |
[Influence of induced nitric oxide synthase expression on apoptosis of thymocyte in burn rats].
Topics: Animals; Apoptosis; Burns; Gene Expression Regulation; Isothiuronium; Male; Nitric Oxide Synthase Type II; Organ Size; Rats; Rats, Wistar; Thymus Gland | 2006 |
Probing the structure and activity of trypsin with amidination.
Topics: Amines; Amino Acid Sequence; Animals; Autolysis; Binding Sites; Cattle; Cytochromes c; In Vitro Techniques; Isothiuronium; Methylation; Molecular Sequence Data; Molecular Structure; Pepsin A; Peptide Fragments; Protein Denaturation; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 2007 |
[Animal experimental study of intra-articular injection of S-methylisothiourea for treatment of temporomandibular joint osteoarthrosis].
Topics: Animals; Injections, Intra-Articular; Isothiuronium; Osteoarthritis; Temporomandibular Joint; Temporomandibular Joint Disc; Temporomandibular Joint Disorders | 2007 |
A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Boswellia; Caspases; Cell Nucleus; Cell Proliferation; Cells, Cultured; DNA Fragmentation; Enzyme Inhibitors; Free Radical Scavengers; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; Isothiuronium; Macrophages, Peritoneal; Membrane Potentials; Mice; Microtubule-Associated Proteins; Mitochondria; Molecular Structure; Nitric Oxide; Plant Extracts; Poly(ADP-ribose) Polymerases; Reactive Nitrogen Species; Reactive Oxygen Species; Repressor Proteins; Survivin; Triterpenes | 2007 |
Antagonism of lipopolysaccharide-induced blood pressure attenuation and vascular contractility.
Topics: Animals; Aorta; Blood Pressure; Cytokines; Disaccharides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Isothiuronium; Lipopolysaccharides; Mice; Mice, Inbred C3H; Mice, Mutant Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Point Mutation; RNA, Messenger; Shock, Septic; Signal Transduction; Sugar Phosphates; Time Factors; Toll-Like Receptor 4; Vasoconstriction | 2007 |
Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Enzyme Inhibitors; Female; Ganglia, Spinal; Herpesvirus 1, Human; Hyperalgesia; Indazoles; Isothiuronium; Mice; Mice, Inbred C57BL; Neuralgia, Postherpetic; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nociceptors; Posterior Horn Cells; RNA, Messenger; Up-Regulation | 2007 |
The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in formalin-induced pain in mice: an isobolographic study.
Topics: Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Formaldehyde; Isothiuronium; Lactones; Male; Mefenamic Acid; Membrane Proteins; Mice; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Sulfones; Time Factors | 2008 |
Intermittent hypoxia modulates nitric oxide-dependent vasodilation and capillary perfusion during ischemia-reperfusion-induced damage.
Topics: Acetylcholine; Animals; Blood Flow Velocity; Blood Pressure; Capillaries; Cheek; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Heart Rate; Hematocrit; Hypoxia; Isothiuronium; Male; Mesocricetus; Microscopy, Video; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Regional Blood Flow; Stress, Mechanical; Thiobarbituric Acid Reactive Substances; Time Factors; Vasodilation; Vasodilator Agents | 2008 |
Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Caspases; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Glucose; Hypoxia; In Situ Nick-End Labeling; Isothiuronium; Microglia; Models, Biological; Neurons; NF-kappa B; Rats; Rats, Wistar; Stroke; Tumor Necrosis Factor-alpha | 2008 |
Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis.
Topics: Alanine Transaminase; Animals; Arginine; Blotting, Western; Carbon Tetrachloride; Chronic Disease; Disease Progression; Electrophoretic Mobility Shift Assay; Isothiuronium; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Models, Animal; NF-kappa B; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Procollagen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor AP-1; Transforming Growth Factor beta1 | 2008 |
Malignant alterations following early blockade of nitric oxide synthase in hypertensive rats.
Topics: Animals; Blood Pressure; Blood Urea Nitrogen; Body Weight; Endothelin-1; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Isothiuronium; Kidney; Kidney Function Tests; Lysine; Muscle Weakness; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Ventricular Function, Left | 2007 |
Melatonin inhibits amphetamine-induced nitric oxide synthase mRNA overexpression in microglial cell lines.
Topics: Amphetamine; Animals; Cell Line, Transformed; Central Nervous System Depressants; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Isothiuronium; Lipopolysaccharides; Melatonin; Microglia; Nitric Oxide Synthase; Rats; RNA, Messenger | 2008 |
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Enzyme Inhibitors; Infusions, Parenteral; Isothiuronium; Lung Injury; Nitric Oxide Synthase Type II; Pneumonia, Aspiration; Rats; Rats, Sprague-Dawley | 2008 |
Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Guanidines; Immunohistochemistry; Ischemic Preconditioning; Isothiuronium; Kidney; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2008 |
Nitric oxide and superoxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translocation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Analysis of Variance; Animals; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Blotting, Western; Cell Nucleus; Cytochromes c; Enzyme-Linked Immunosorbent Assay; Isothiuronium; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Superoxides; Thoracic Vertebrae | 2009 |
Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Cell Death; Cells, Cultured; Chlorides; Coculture Techniques; Dopamine; Enzyme Inhibitors; Interleukin-1beta; Isothiuronium; Manganese Compounds; Microglia; Minocycline; Neurons; Neurotoxins; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Isothiuronium; Male; Nitric Oxide Synthase Type II; Propofol; Rats; Rats, Sprague-Dawley; Sepsis | 2009 |
Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medulla.
Topics: Action Potentials; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Imidazoles; Immunohistochemistry; Infusions, Parenteral; Injections, Intravenous; Injections, Intraventricular; Isothiuronium; Kidney; Male; Medulla Oblongata; Neural Inhibition; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Sympatholytics; Time Factors | 2009 |
[Nitrogen monoxide and functional activity of large conductance Ca-activated potassium channels in coronary vessels in rats with limited motor activity].
Topics: Animals; Endothelium, Vascular; Female; Immobilization; In Vitro Techniques; Ion Channel Gating; Isothiuronium; Large-Conductance Calcium-Activated Potassium Channels; Myocardial Contraction; Myocardium; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Potassium Channel Blockers; Rats; Stress, Psychological; Tetraethylammonium | 2009 |
Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis.
Topics: Aldehyde Oxidoreductases; Animals; ATP-Binding Cassette Transporters; Bile Ducts; Cholagogues and Choleretics; Cholestasis; Down-Regulation; Enzyme Inhibitors; Homeostasis; Isothiuronium; Ligation; Liver; Male; Nitric Oxide; Nitrosation; Proteins; Rats; Rats, Wistar; RNA, Messenger; S-Nitrosothiols; Taurochenodeoxycholic Acid | 2010 |
Neuroprotective effect of s-methylisothiourea in transient focal cerebral ischemia in rat.
Topics: Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ischemic Attack, Transient; Isothiuronium; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Structure-Activity Relationship | 2010 |
Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Glutathione Peroxidase; Ileum; Intestinal Mucosa; Isothiuronium; Male; Malondialdehyde; Melatonin; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2010 |
Hemodynamic effects of inducible nitric oxide synthase inhibition combined with sildenafil during acute pulmonary embolism.
Topics: Acute Disease; Animals; Dogs; Female; Hemodynamics; Isothiuronium; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Piperazines; Pulmonary Embolism; Purines; Sildenafil Citrate; Sulfones; Thiobarbituric Acid Reactive Substances | 2010 |
S-methylisothiourea induces apoptosis of herpes simplex virus-1-infected microglial cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Caspases; Cell Line; Encephalitis, Herpes Simplex; Enzyme Inhibitors; Herpesvirus 1, Human; Interleukin-10; Interleukin-1beta; Isothiuronium; Male; Mice; Mice, Inbred BALB C; Microglia; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha | 2011 |
Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice.
Topics: Actins; Animals; Arginine; Biomarkers; Cyclooxygenase 2; Drug Therapy, Combination; Enzyme Inhibitors; Gene Expression Regulation; Hepatocytes; Isothiuronium; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Effect of selective inhibitors of nitric oxide synthesis on the course of experimental hemorrhagic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Enzyme Inhibitors; Isothiuronium; Lysine; Microcirculation; Nitric Oxide Synthase; Ornithine; Rats; Shock, Hemorrhagic | 2010 |
Inhibition of iNOS reduces the therapeutic effects of ozone in acute necrotizing pancreatitis: an in vivo animal study.
Topics: Animals; Blood Proteins; Escherichia coli; Isothiuronium; Lipid Peroxidation; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Ozone; Pancreas; Pancreatitis, Acute Necrotizing; Proteus mirabilis; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 2011 |
Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats.
Topics: Adrenomedullin; Animals; Arginine; Baroreflex; Bronchodilator Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Ornithine; Rats; Rats, Sprague-Dawley; S-Nitrosoglutathione; Signal Transduction; Solitary Nucleus | 2011 |
Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Evoked Potentials, Visual; In Situ Nick-End Labeling; Injections, Intraperitoneal; Intraocular Pressure; Isothiuronium; Male; Metalloporphyrins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Ocular Hypertension; Oxidative Stress; Rats; Rats, Wistar; Retina; Retinal Diseases; Tandem Mass Spectrometry; Vitreous Body | 2011 |
Effects of nitric oxide on the survival and neuritogenesis of cerebellar Purkinje neurons.
Topics: Animals; Benzoates; Cell Count; Cells, Cultured; Cerebellar Cortex; Citrulline; Female; Imidazoles; Isothiuronium; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Neurites; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Peroxynitrous Acid; Pregnancy; Purkinje Cells; Reactive Nitrogen Species; Thiourea | 2012 |
Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Cell Count; Cell Line, Transformed; Cytokines; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Imidazoles; Interleukin-10; Isothiuronium; Lipopolysaccharides; Male; Mice; Microglia; Nitric Oxide Synthase Type II; Pyridines; Rats; RNA, Messenger; Tumor Necrosis Factor-alpha | 2011 |
Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit.
Topics: Acetylcholine; Alloxan; Animals; Arteries; Bradykinin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endothelium, Vascular; Enzyme Inhibitors; Female; Indomethacin; Isometric Contraction; Isothiuronium; Male; Muscarinic Antagonists; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Nitroprusside; Parotid Gland; Phenylephrine; Potassium; Rabbits; Random Allocation; Receptor, Muscarinic M3; Vasoconstrictor Agents; Vasodilation | 2011 |
15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway.
Topics: Animals; Apoptosis; Caspase 3; Cell Hypoxia; Cell Nucleus Size; Cell Survival; DNA Fragmentation; Enzyme Activation; Enzyme Precursors; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Isothiuronium; Male; Membrane Potential, Mitochondrial; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type II; Pulmonary Artery; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Up-Regulation | 2012 |
Synthetic studies on novel 1,4-dihydro-2-methylthio-4,4,6-trisubstituted pyrimidine-5-carboxylic acid esters and their tautomers.
Topics: Carboxylic Acids; Chemistry Techniques, Synthetic; Cyclization; Esters; Isomerism; Isothiuronium; Magnetic Resonance Spectroscopy; Pyrimidines | 2011 |
Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity.
Topics: Animals; Chemical Warfare Agents; Disease Models, Animal; Inflammation; Isothiuronium; Kidney Diseases; Male; Mechlorethamine; Melatonin; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley | 2012 |
Cytochrome-c mediated a bystander response dependent on inducible nitric oxide synthase in irradiated hepatoma cells.
Topics: Bystander Effect; Carcinoma, Hepatocellular; Cell Line, Tumor; Coculture Techniques; Cyclosporine; Cytochromes c; Gamma Rays; Hep G2 Cells; Humans; Isothiuronium; Liver Neoplasms; Micronucleus Tests; Nitric Oxide; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Signal Transduction | 2012 |
The role of iNOS inhibitors on lung injury induced by gastrointestinal decontamination agents aspiration.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Charcoal; Enzyme Inhibitors; Gastrointestinal Agents; Histiocytes; Isothiuronium; Lung; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Polyethylene Glycols; Pulmonary Surfactant-Associated Protein D; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2012 |
The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite.
Topics: Animals; Benzoates; Cyclic GMP; Guanidines; Guanylate Cyclase; Imidazoles; Isothiuronium; Larva; Metamorphosis, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Thoracica | 2012 |
Effect of S-methylisothiourea in acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Isothiuronium; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Time Factors | 2012 |
TNF-alpha decreases infection-induced lung injury in burn through negative regulation of TLR4/iNOS.
Topics: Animals; Burns; Comorbidity; Enzyme Inhibitors; Interleukin-1beta; Isothiuronium; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Nitric Oxide Synthase Type II; Pseudomonas aeruginosa; Pseudomonas Infections; Receptors, Tumor Necrosis Factor, Type I; Toll-Like Receptor 4; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Evaluation of the effects of S-methylisothiourea hemisulfate, an inducible nitric oxide synthase inhibitor, on the healing of colonic anastomosis in rats.
Topics: Anastomosis, Surgical; Animals; Colon; Isothiuronium; Male; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tensile Strength; Time Factors; Wound Healing | 2012 |
Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intra-Articular; Iodoacetic Acid; Isothiuronium; Male; Nitric Oxide Synthase Type II; Osteoarthritis; Pain; Pilot Projects; Rats; Rats, Wistar; Treatment Outcome | 2013 |
Induction of Toll-like receptor 4 signaling in avian macrophages inhibits infectious laryngotracheitis virus replication in a nitric oxide dependent way.
Topics: Animals; Cell Line; Chickens; Enzyme Inhibitors; Flow Cytometry; Herpesviridae Infections; Herpesvirus 1, Gallid; Isothiuronium; Lipopolysaccharides; Macrophages; Nitric Oxide; Poultry Diseases; Signal Transduction; Toll-Like Receptor 4; Virus Replication | 2013 |
The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats.
Topics: Animals; Chemical Warfare Agents; Interleukin-1beta; Isothiuronium; Lung; Lung Diseases; Male; Mechlorethamine; Melatonin; Pneumonia; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Tumor Necrosis Factor-alpha | 2013 |
Chondroprotective and anti-inflammatory effects of S-methylisothiourea, an inducible nitric oxide synthase inhibitor in cartilage and synovial explants model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Chondrocytes; Cytokines; Enzyme Inhibitors; Glycosaminoglycans; Humans; Hydroxyproline; In Vitro Techniques; Inflammation; Inflammation Mediators; Isothiuronium; Lipopolysaccharides; Male; Matrix Metalloproteinase 13; Nitric Oxide Synthase Type II; Nitrites; Osteoarthritis; Rabbits; Rats; Rats, Wistar; Synovial Membrane | 2014 |
Irradiated U937 cells trigger inflammatory bystander responses in human umbilical vein endothelial cells through the p38 pathway.
Topics: Atherosclerosis; Benzoates; Bystander Effect; Coculture Techniques; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Isothiuronium; Macrophages; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; U937 Cells | 2014 |
The comparative proteomics analysis revealed the modulation of inducible nitric oxide on the immune response of scallop Chlamys farreri.
Topics: Animals; Electrophoresis, Gel, Two-Dimensional; Hepatopancreas; Immunity, Innate; Isothiuronium; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase Type II; Pectinidae; Proteome | 2014 |
[The special role of inducible NO-synthase in the mechanism of rat coronary vessels tone regulation during immobilization stress, combined with diabetes mellitus].
Topics: Animals; Coronary Vessels; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Immobilization; Isothiuronium; Muscle Tonus; Muscle, Smooth, Vascular; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Rats | 2014 |
The anti-apoptotic effect of polypeptide from Chlamys farreri (PCF) in UVB-exposed HaCaT cells involves inhibition of iNOS and TGF-β1.
Topics: Animals; Apoptosis; Benzamides; Cell Line; Dioxoles; Gene Expression Regulation; Humans; Isothiuronium; Nitric Oxide Synthase Type II; Pectinidae; Peptides; Phosphoproteins; Smad Proteins; Transforming Growth Factor beta1; Ultraviolet Rays | 2015 |
Inducible nitric oxide inhibitor enhances the anti-tumor effect of cisplatin on CNE-2 cells by inducing cell apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isothiuronium; Lung Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Nitric Oxide Synthase Type II | 2014 |
Changes in the profile of NO synthases affect coronary blood flow autoregulation and myocardial contractile activity during restraint stress in rats.
Topics: Animals; Coronary Circulation; DNA Primers; Homeostasis; Isothiuronium; Male; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Restraint, Physical; Spectrophotometry; Statistics, Nonparametric; Stress, Physiological; Ventricular Pressure | 2014 |
[Changes in endothelium-dependent dilation and α1-adrenoreactivity of rat aorta caused by inducible NO-synthase inhibition after motor activity restrictions].
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Agonists; Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Female; Immobilization; Isothiuronium; Motor Activity; Nitric Oxide; Nitric Oxide Synthase Type II; Organ Culture Techniques; Rats; Stress, Physiological; Vasodilation | 2013 |
Nitric oxide synthase modulates the antihyperalgesic effect of the NMDA receptor antagonist MK-801 on Carrageenan-induced inflammatory pain in rats.
Topics: Animals; Arginine; Carrageenan; Dizocilpine Maleate; Hyperalgesia; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2014 |
Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription.
Topics: Animals; Apolipoproteins E; Chromones; Estrenes; Indoles; Isothiuronium; Maleimides; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; PC12 Cells; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-akt; Pyrrolidinones; Rats; Signal Transduction; Transcription, Genetic; Type C Phospholipases | 2015 |
Attenuation of bleomycin induced lung fibrosis by erdosteine and inhibition of the inducible nitric oxide synthase.
Topics: Acute Lung Injury; Animals; Bleomycin; Drug Therapy, Combination; Enzyme Inhibitors; Expectorants; Injections, Intraperitoneal; Isothiuronium; Lung; Male; Nitric Oxide Synthase Type II; Pulmonary Fibrosis; Random Allocation; Rats; Rats, Sprague-Dawley; Thioglycolates; Thiophenes; Tumor Necrosis Factor-alpha | 2015 |
[INVOLVEMENT OF NO-SYNTHASE IN THE INFARCT REDUCING EFFECT OF CONTINUOUS CHRONIC NORMOBARTC HYPOXTA].
Topics: Animals; Hypoxia; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar | 2015 |
Effects and Mechanism of Action of Inducible Nitric Oxide Synthase on Apoptosis in a Rat Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Behavior, Animal; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Isothiuronium; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway.
Topics: Animals; Biofouling; Cyclic GMP; Enzyme Inhibitors; Hydroxybenzoates; Isothiuronium; Lactones; Larva; Nitric Oxide; Surface-Active Agents; Thoracica | 2016 |
The Effect of the iNOS Inhibitor S-Methylisothiourea and Hyperbaric Oxygen Treatment on Radiation Colitis in Rats.
Topics: Animals; Colitis; Colon; Enzyme Inhibitors; Female; Hyperbaric Oxygenation; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1beta; Isothiuronium; Nitric Oxide Synthase Type II; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2016 |
Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis.
Topics: Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Fibrosis; Fluorescent Antibody Technique; Glucose Tolerance Test; Isothiuronium; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; RAW 264.7 Cells | 2016 |
Endogenous nitric oxide derived from NOS I or II in thoracic spinal cord exerts opposing tonic modulation on sympathetic vasomotor tone via disparate mechanisms in anesthetized rats.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Axons; Blood Pressure; Blood Vessels; Dendrites; Enzyme Inhibitors; Heart Rate; Indazoles; Isothiuronium; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Norepinephrine; Rats; Rats, Sprague-Dawley; Spinal Cord; Sympathetic Nervous System; Thoracic Vertebrae; Vasomotor System | 2016 |
Inhibition of neuronal and inducible nitric oxide synthase does not affect the analgesic effects of NMDA antagonists in visceral inflammatory pain.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channel Blockers; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indicators and Reagents; Isothiuronium; Magnesium Sulfate; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain Measurement; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors; Visceral Pain | 2016 |
Cardiovascular risk and the effect of nitric oxide synthase inhibition in female rats: The role of estrogen.
Topics: Animals; Antioxidants; Aryldialkylphosphatase; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Estradiol; Estrogens; Female; Heart Rate; Isothiuronium; Lipid Peroxides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ovariectomy; Rats; Rats, Wistar | 2017 |
A new promising simultaneous approach for attenuating type II diabetes mellitus induced neuropathic pain in rats: iNOS inhibition and neuroregeneration.
Topics: Animals; Blood Glucose; Body Weight; Cytidine Diphosphate Choline; Diabetes Mellitus, Type 2; Drug Interactions; Enzyme Inhibitors; Hyperalgesia; Isothiuronium; Male; Motor Neurons; Nervous System; Neuralgia; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Regeneration | 2018 |
Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Carrageenan; Dizocilpine Maleate; Edema; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2019 |
[A MODULATORY INFLUENCE OF THE iNOS ON THE FUNCTIONAL ACTIVITY OF THE KATP-CHANNELS IN CORONARY VESSELS OF RATS ADAPTED TO THE STRESS].
Topics: Adaptation, Physiological; Animals; Animals, Outbred Strains; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression Regulation; Glyburide; Heart; Immobilization; Isothiuronium; KATP Channels; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Culture Techniques; Perfusion; Potassium Channel Blockers; Rats; Stress, Psychological | 2016 |
Involvement of inducible nitric oxide synthase (iNOS) in immune-functioning of Paphia malabarica (Chemnitz, 1782).
Topics: Animals; Anti-Bacterial Agents; Bivalvia; Enzyme Inhibitors; Fluorescent Antibody Technique; Hemocytes; Isothiuronium; Nitric Oxide Synthase Type II; Vibrio cholerae; Vibrio parahaemolyticus | 2019 |
Inducible Nitric Oxide Synthase (
Topics: Animals; Anticoagulants; Apoptosis; Blood Coagulation; Carps; Cell Line; Endothelial Cells; Enzyme Inhibitors; Fish Diseases; Hemorrhage; Isothiuronium; Models, Biological; Nitric Oxide Synthase Type II; Reoviridae; Reoviridae Infections | 2019 |