isothiuronium has been researched along with etiron in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 16 (55.17) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hurley, DJ; Mastro, AM | 1 |
| Fowler, M; Furfine, ES; Garvey, EP; Harmon, MF; Marshall, S; Oplinger, JA; Paith, JE; Sherman, PA; Tanoury, GJ | 1 |
| Basha, F; Budzik, GP; Carter, GW; Donnelly, JL; Klinghofer, V; Kuk, JE; Nakane, M; Pollock, JS | 1 |
| Basha, F; Carter, G; Nakane, M; Tracey, WR | 1 |
| Booke, M; Hinder, F; McGuire, R; Traber, DL; Traber, LD | 2 |
| Kirk, A; Nicholls, DJ; Wallace, AV | 1 |
| Asahi, M; Fujii, J; Fujiwara, N; Kaneto, H; Seo, HG; Taniguchi, N | 1 |
| Altavilla, D; Campo, GM; Canale, P; Caputi, AP; Ioculano, M; Rossi, F; Saitta, A; Squadrito, F; Squadrito, G | 1 |
| Fujii, E; Horikawa, H; Irie, K; Muraki, T; Ohba, K; Okada, M | 1 |
| Chaudhuri, G; Ignarro, LJ; Pervin, S; Rogers, NE; Singh, R | 1 |
| Dick, JM; Lefebvre, RA | 1 |
| Abman, SH; Fan, ID; Horan, MP; Ivy, DD; Kinsella, JP; Le Cras, TD; Rairigh, RL; Richter, G | 1 |
| Alderton, WK; Boyhan, A; Lowe, PN | 1 |
| Cross, AH; McCarthy, TJ; Welch, MJ; Zhang, J | 1 |
| Alhan, E; Erçin, C; Küçütülü, U | 1 |
| Arabolos, N; Ignarro, LJ; Wei, LH | 1 |
| Allen, JD; Kelso, EJ; McDermott, BJ; Silke, B; Spiers, JP | 1 |
| Aspelin, T; Egeland, T; Höiby, EA; Lermark, G; Lyberg, T; Saetre, T | 1 |
| Král, V; Li, H; Martásek, P; Masters, BS; Poulos, TL; Raman, CS | 1 |
| Decking, UK; Flögel, U; Godecke, A; Merx, MW; Schrader, J | 1 |
| Bardell, AL; MacLeod, KM | 1 |
| Alexander, BT; Cline, FD; Cockrell, K; Granger, JP | 1 |
| Ajiki, K; Nakashima, K; Nakashima, MN; Takahashi, M | 1 |
| Flögel, U; Gödecke, A; Heger, J; Schrader, J; Wunderlich, C | 1 |
| Aiken, BA; Edwards, JA; McLoughlin, TJ; Pizza, FX; Tsivitse, SK | 1 |
| Boengler, K; Gres, P; Heusch, G; Kelm, M; Kleinbongard, P; Konietzka, I; Martin, C; Post, H; Schulz, R; Skyschally, A | 1 |
| Borer, JS; Ciubotaru, A; Manolache, G; Sasson, L; Schachner, A; Ureche, A | 1 |
| Lu, L; Nakamura, K; Shimizu, T; Yokotani, K | 1 |
1 trial(s) available for isothiuronium and etiron
| Article | Year |
|---|---|
Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety.
Topics: Adult; Aged; Blood Pressure; Cardiac Surgical Procedures; Cardiovascular Diseases; Double-Blind Method; Enzyme Inhibitors; Female; Half-Life; Hemodynamics; Humans; Hypotension; Isothiuronium; Male; Middle Aged; Nitric Oxide Synthase; Pilot Projects; Placebos; Vascular Resistance | 2008 |
28 other study(ies) available for isothiuronium and etiron
| Article | Year |
|---|---|
System for enumerating and separating bovine lymphocytes, using coordinated En and Ea markers: evaluation of lymph node lymphocytes.
Topics: Animals; Cattle; Cell Separation; Culture Media; Erythrocytes; Female; Hypnotics and Sedatives; Isothiuronium; Lymph Nodes; Male; Neuraminidase; Rosette Formation; Sheep; T-Lymphocytes; Vasoconstrictor Agents | 1983 |
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Endothelium, Vascular; Enzyme Induction; Humans; Isoenzymes; Isothiuronium; Kinetics; Mice; Models, Chemical; Neurons; Nitric Oxide Synthase; Species Specificity; Structure-Activity Relationship; Thiazoles; Thiourea | 1994 |
Novel potent and selective inhibitors of inducible nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Enzyme Induction; Isoenzymes; Isothiuronium; Mice; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Rats; Thiazines | 1995 |
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isothiuronium; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sepsis; Thiazines | 1995 |
S-ethylisothiourea, a nonamino acid inhibitor of nitric oxide synthase, reverses septic vasodilation in sheep.
Topics: Animals; Cardiac Output; Enzyme Inhibitors; Female; Hemodynamics; Hypotension; Infusions, Intravenous; Isothiuronium; Lung; Nitric Oxide Synthase; Oxygen Consumption; Pseudomonas Infections; Sepsis; Sheep; Vascular Resistance; Vasoconstrictor Agents; Vasodilation; Water-Electrolyte Balance | 1995 |
Reversibility of inhibition of human type II nitric oxide synthase.
Topics: Adenosine Diphosphate; Animals; Arginine; Cell Line; Colonic Neoplasms; Enzyme Inhibitors; Humans; Isoenzymes; Isothiuronium; Kinetics; Macrophages; Mice; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Onium Compounds; Tumor Cells, Cultured | 1996 |
Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits.
Topics: Animals; Blood Pressure; Brain; Cells, Cultured; Citrulline; Colforsin; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Interleukin-1; Isothiuronium; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitric Oxide Synthase; Nitrites; Nucleosomes; Rabbits; Rats; Shock, Septic | 1996 |
Effects of S-ethylisothiourea, a potent inhibitor of nitric oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Drug Therapy, Combination; In Vitro Techniques; Isothiuronium; Leukocyte Count; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Peroxidase; Phenylephrine; Rats; Rats, Sprague-Dawley; Shock; Sydnones | 1996 |
Effect of S-ethylisothiourea, a putative inhibitor of inducible nitric oxide synthase, on mouse skin vascular permeability.
Topics: Animals; Capillary Permeability; Enzyme Inhibitors; Isothiuronium; Lipopolysaccharides; Male; Mice; Nitric Oxide Synthase; Platelet Activating Factor; Salmonella typhimurium; Serotonin; Skin | 1996 |
Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney.
Topics: Animals; Calcium; Calmodulin; Citrulline; Enzyme Inhibitors; Female; Guinea Pigs; Isoenzymes; Isothiuronium; Kidney; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pregnancy; Rats; Rats, Sprague-Dawley; Sepharose | 1997 |
Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
Topics: Animals; Biotin; Citrulline; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Isothiuronium; Lysine; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Swine; Thiourea | 1997 |
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus.
Topics: Acetylcholine; Animals; Aorta; Blotting, Northern; Enzyme Inhibitors; Female; Gestational Age; Guanidines; Hemodynamics; Isothiuronium; Lung; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Pulmonary Artery; Rats; Sheep; Thiazines; Vascular Resistance | 1998 |
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins | 1998 |
Measurement of upregulation of inducible nitric oxide synthase in the experimental autoimmune encephalomyelitis model using a positron emitting radiopharmaceutical.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Isothiuronium; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiopharmaceuticals; Tomography, Emission-Computed; Up-Regulation | 1997 |
The effects of nitric oxide synthase inhibitors on acute necrotising pancreatitis in rats.
Topics: Amylases; Animals; Calcium; Creatinine; Enzyme Inhibitors; Isothiuronium; L-Lactate Dehydrogenase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreas; Pancreatitis, Acute Necrotizing; Rats; Rats, Sprague-Dawley; Transaminases; Urea | 1998 |
Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein.
Topics: Animals; beta-Aminoethyl Isothiourea; Blotting, Western; Cell Line; Enzyme Induction; Enzyme Inhibitors; Enzyme Stability; Isothiuronium; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Biosynthesis; Thiourea; Transcription, Genetic | 1998 |
Selective inhibition of inducible nitric oxide synthase: effects on hemodynamics and regional blood flow in healthy and septic sheep.
Topics: Animals; Bacteremia; Critical Care; Dose-Response Relationship, Drug; Female; Hemodynamics; Isothiuronium; Microcirculation; Microspheres; Nitric Oxide Synthase; Oxygen; Prospective Studies; Pseudomonas aeruginosa; Pseudomonas Infections; Random Allocation; Regional Blood Flow; Sheep; Vasoconstrictor Agents | 1999 |
Inotropic response to endothelin-1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: effects of ethyl-isothiourea and dexamethasone.
Topics: Animals; Calcium; Dexamethasone; Dose-Response Relationship, Drug; Endothelin-1; Endotoxins; Heart Ventricles; Isoproterenol; Isothiuronium; Lipopolysaccharides; Male; Myocardial Contraction; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Ventricular Function | 2000 |
Aminoethyl-isothiourea, a nitric oxide synthase inhibitor and oxygen radical scavenger, improves survival and counteracts hemodynamic deterioration in a porcine model of streptococcal shock.
Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Isothiuronium; Male; Nitric Oxide; Random Allocation; Shock, Septic; Streptococcal Infections; Streptococcus pyogenes; Survival Rate; Swine; Thiourea | 2000 |
Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
Topics: Binding Sites; Crystallography, X-Ray; Endothelium; Heme; Humans; Isothiuronium; Kinetics; Models, Molecular; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Thiourea | 2000 |
Myoglobin: A scavenger of bioactive NO.
Topics: Animals; Bradykinin; Coronary Circulation; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Isothiuronium; Magnetic Resonance Spectroscopy; Metmyoglobin; Mice; Mice, Knockout; Mitochondria, Heart; Models, Biological; Myocardial Contraction; Myocardium; Myoglobin; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Vasodilation; Vasodilator Agents | 2001 |
Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Immunohistochemistry; Indazoles; Insulin; Isothiuronium; Male; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Ornithine; Rats; Rats, Wistar | 2001 |
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy.
Topics: Animals; Enzyme Inhibitors; Female; Hemodynamics; Isothiuronium; Kidney; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley | 2002 |
Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice.
Topics: Animals; Anxiety; Carotid Arteries; Enzyme Inhibitors; Exploratory Behavior; Indazoles; Interpersonal Relations; Ischemic Attack, Transient; Isothiuronium; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I | 2003 |
Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts.
Topics: Adenosine Triphosphate; Animals; Arginine; Carbon Dioxide; Carbon Monoxide; Enzyme Inhibitors; Genotype; Heart; In Vitro Techniques; Isothiuronium; Magnetic Resonance Spectroscopy; Metmyoglobin; Mice; Mice, Transgenic; Myocardial Contraction; Myocardium; Myoglobin; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrogen; Oxygen; Perfusion; Phosphocreatine; Ventricular Pressure | 2003 |
Deferoxamine reduces and nitric oxide synthase inhibition increases neutrophil-mediated myotube injury.
Topics: Catalase; CD18 Antigens; Chromium; Chromium Radioisotopes; Culture Media, Conditioned; Deferoxamine; Humans; Hydroxyl Radical; Iron Chelating Agents; Isothiuronium; Luminescent Measurements; Muscle Fibers, Skeletal; Neutrophils; Nitric Oxide Synthase; Reactive Oxygen Species; Superoxide Dismutase | 2003 |
Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia.
Topics: Animals; Biomarkers; Extracellular Fluid; Isothiuronium; Microdialysis; Microscopy, Confocal; Mitochondria, Heart; Models, Animal; Myocardial Ischemia; Myocardial Reperfusion; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Oxyhemoglobins; Staining and Labeling; Swine; Swine, Miniature | 2007 |
Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Bombesin; Brain; Catecholamines; Cycloheximide; Cyclooxygenase 1; Indazoles; Isothiuronium; Ketoprofen; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrobenzenes; Rats; Rats, Wistar; Sulfonamides | 2008 |