Page last updated: 2024-08-23

isothiuronium and etiron

isothiuronium has been researched along with etiron in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.45)18.7374
1990's16 (55.17)18.2507
2000's12 (41.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hurley, DJ; Mastro, AM1
Fowler, M; Furfine, ES; Garvey, EP; Harmon, MF; Marshall, S; Oplinger, JA; Paith, JE; Sherman, PA; Tanoury, GJ1
Basha, F; Budzik, GP; Carter, GW; Donnelly, JL; Klinghofer, V; Kuk, JE; Nakane, M; Pollock, JS1
Basha, F; Carter, G; Nakane, M; Tracey, WR1
Booke, M; Hinder, F; McGuire, R; Traber, DL; Traber, LD2
Kirk, A; Nicholls, DJ; Wallace, AV1
Asahi, M; Fujii, J; Fujiwara, N; Kaneto, H; Seo, HG; Taniguchi, N1
Altavilla, D; Campo, GM; Canale, P; Caputi, AP; Ioculano, M; Rossi, F; Saitta, A; Squadrito, F; Squadrito, G1
Fujii, E; Horikawa, H; Irie, K; Muraki, T; Ohba, K; Okada, M1
Chaudhuri, G; Ignarro, LJ; Pervin, S; Rogers, NE; Singh, R1
Dick, JM; Lefebvre, RA1
Abman, SH; Fan, ID; Horan, MP; Ivy, DD; Kinsella, JP; Le Cras, TD; Rairigh, RL; Richter, G1
Alderton, WK; Boyhan, A; Lowe, PN1
Cross, AH; McCarthy, TJ; Welch, MJ; Zhang, J1
Alhan, E; Erçin, C; Küçütülü, U1
Arabolos, N; Ignarro, LJ; Wei, LH1
Allen, JD; Kelso, EJ; McDermott, BJ; Silke, B; Spiers, JP1
Aspelin, T; Egeland, T; Höiby, EA; Lermark, G; Lyberg, T; Saetre, T1
Král, V; Li, H; Martásek, P; Masters, BS; Poulos, TL; Raman, CS1
Decking, UK; Flögel, U; Godecke, A; Merx, MW; Schrader, J1
Bardell, AL; MacLeod, KM1
Alexander, BT; Cline, FD; Cockrell, K; Granger, JP1
Ajiki, K; Nakashima, K; Nakashima, MN; Takahashi, M1
Flögel, U; Gödecke, A; Heger, J; Schrader, J; Wunderlich, C1
Aiken, BA; Edwards, JA; McLoughlin, TJ; Pizza, FX; Tsivitse, SK1
Boengler, K; Gres, P; Heusch, G; Kelm, M; Kleinbongard, P; Konietzka, I; Martin, C; Post, H; Schulz, R; Skyschally, A1
Borer, JS; Ciubotaru, A; Manolache, G; Sasson, L; Schachner, A; Ureche, A1
Lu, L; Nakamura, K; Shimizu, T; Yokotani, K1

Trials

1 trial(s) available for isothiuronium and etiron

ArticleYear
Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety.
    Cardiology, 2008, Volume: 111, Issue:3

    Topics: Adult; Aged; Blood Pressure; Cardiac Surgical Procedures; Cardiovascular Diseases; Double-Blind Method; Enzyme Inhibitors; Female; Half-Life; Hemodynamics; Humans; Hypotension; Isothiuronium; Male; Middle Aged; Nitric Oxide Synthase; Pilot Projects; Placebos; Vascular Resistance

2008

Other Studies

28 other study(ies) available for isothiuronium and etiron

ArticleYear
System for enumerating and separating bovine lymphocytes, using coordinated En and Ea markers: evaluation of lymph node lymphocytes.
    American journal of veterinary research, 1983, Volume: 44, Issue:12

    Topics: Animals; Cattle; Cell Separation; Culture Media; Erythrocytes; Female; Hypnotics and Sedatives; Isothiuronium; Lymph Nodes; Male; Neuraminidase; Rosette Formation; Sheep; T-Lymphocytes; Vasoconstrictor Agents

1983
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.
    The Journal of biological chemistry, 1994, Oct-28, Volume: 269, Issue:43

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Endothelium, Vascular; Enzyme Induction; Humans; Isoenzymes; Isothiuronium; Kinetics; Mice; Models, Chemical; Neurons; Nitric Oxide Synthase; Species Specificity; Structure-Activity Relationship; Thiazoles; Thiourea

1994
Novel potent and selective inhibitors of inducible nitric oxide synthase.
    Molecular pharmacology, 1995, Volume: 47, Issue:4

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Enzyme Induction; Isoenzymes; Isothiuronium; Mice; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Rats; Thiazines

1995
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors.
    Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isothiuronium; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sepsis; Thiazines

1995
S-ethylisothiourea, a nonamino acid inhibitor of nitric oxide synthase, reverses septic vasodilation in sheep.
    Shock (Augusta, Ga.), 1995, Volume: 4, Issue:4

    Topics: Animals; Cardiac Output; Enzyme Inhibitors; Female; Hemodynamics; Hypotension; Infusions, Intravenous; Isothiuronium; Lung; Nitric Oxide Synthase; Oxygen Consumption; Pseudomonas Infections; Sepsis; Sheep; Vascular Resistance; Vasoconstrictor Agents; Vasodilation; Water-Electrolyte Balance

1995
Reversibility of inhibition of human type II nitric oxide synthase.
    Biochemical Society transactions, 1996, Volume: 24, Issue:1

    Topics: Adenosine Diphosphate; Animals; Arginine; Cell Line; Colonic Neoplasms; Enzyme Inhibitors; Humans; Isoenzymes; Isothiuronium; Kinetics; Macrophages; Mice; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Onium Compounds; Tumor Cells, Cultured

1996
Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits.
    Journal of biochemistry, 1996, Volume: 119, Issue:3

    Topics: Animals; Blood Pressure; Brain; Cells, Cultured; Citrulline; Colforsin; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Interleukin-1; Isothiuronium; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitric Oxide Synthase; Nitrites; Nucleosomes; Rabbits; Rats; Shock, Septic

1996
Effects of S-ethylisothiourea, a potent inhibitor of nitric oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Drug Therapy, Combination; In Vitro Techniques; Isothiuronium; Leukocyte Count; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Peroxidase; Phenylephrine; Rats; Rats, Sprague-Dawley; Shock; Sydnones

1996
Effect of S-ethylisothiourea, a putative inhibitor of inducible nitric oxide synthase, on mouse skin vascular permeability.
    Japanese journal of pharmacology, 1996, Volume: 70, Issue:3

    Topics: Animals; Capillary Permeability; Enzyme Inhibitors; Isothiuronium; Lipopolysaccharides; Male; Mice; Nitric Oxide Synthase; Platelet Activating Factor; Salmonella typhimurium; Serotonin; Skin

1996
Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney.
    Biochemical and biophysical research communications, 1997, Mar-27, Volume: 232, Issue:3

    Topics: Animals; Calcium; Calmodulin; Citrulline; Enzyme Inhibitors; Female; Guinea Pigs; Isoenzymes; Isothiuronium; Kidney; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pregnancy; Rats; Rats, Sprague-Dawley; Sepharose

1997
Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:4

    Topics: Animals; Biotin; Citrulline; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Isothiuronium; Lysine; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Swine; Thiourea

1997
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus.
    The Journal of clinical investigation, 1998, Jan-01, Volume: 101, Issue:1

    Topics: Acetylcholine; Animals; Aorta; Blotting, Northern; Enzyme Inhibitors; Female; Gestational Age; Guanidines; Hemodynamics; Isothiuronium; Lung; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Pulmonary Artery; Rats; Sheep; Thiazines; Vascular Resistance

1998
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
    The Biochemical journal, 1998, May-15, Volume: 332 ( Pt 1)

    Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins

1998
Measurement of upregulation of inducible nitric oxide synthase in the experimental autoimmune encephalomyelitis model using a positron emitting radiopharmaceutical.
    Nitric oxide : biology and chemistry, 1997, Volume: 1, Issue:3

    Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Isothiuronium; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiopharmaceuticals; Tomography, Emission-Computed; Up-Regulation

1997
The effects of nitric oxide synthase inhibitors on acute necrotising pancreatitis in rats.
    The European journal of surgery = Acta chirurgica, 1998, Volume: 164, Issue:9

    Topics: Amylases; Animals; Calcium; Creatinine; Enzyme Inhibitors; Isothiuronium; L-Lactate Dehydrogenase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreas; Pancreatitis, Acute Necrotizing; Rats; Rats, Sprague-Dawley; Transaminases; Urea

1998
Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein.
    Nitric oxide : biology and chemistry, 1998, Volume: 2, Issue:3

    Topics: Animals; beta-Aminoethyl Isothiourea; Blotting, Western; Cell Line; Enzyme Induction; Enzyme Inhibitors; Enzyme Stability; Isothiuronium; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Biosynthesis; Thiourea; Transcription, Genetic

1998
Selective inhibition of inducible nitric oxide synthase: effects on hemodynamics and regional blood flow in healthy and septic sheep.
    Critical care medicine, 1999, Volume: 27, Issue:1

    Topics: Animals; Bacteremia; Critical Care; Dose-Response Relationship, Drug; Female; Hemodynamics; Isothiuronium; Microcirculation; Microspheres; Nitric Oxide Synthase; Oxygen; Prospective Studies; Pseudomonas aeruginosa; Pseudomonas Infections; Random Allocation; Regional Blood Flow; Sheep; Vasoconstrictor Agents

1999
Inotropic response to endothelin-1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: effects of ethyl-isothiourea and dexamethasone.
    British journal of pharmacology, 2000, Volume: 130, Issue:6

    Topics: Animals; Calcium; Dexamethasone; Dose-Response Relationship, Drug; Endothelin-1; Endotoxins; Heart Ventricles; Isoproterenol; Isothiuronium; Lipopolysaccharides; Male; Myocardial Contraction; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Ventricular Function

2000
Aminoethyl-isothiourea, a nitric oxide synthase inhibitor and oxygen radical scavenger, improves survival and counteracts hemodynamic deterioration in a porcine model of streptococcal shock.
    Critical care medicine, 2000, Volume: 28, Issue:8

    Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Isothiuronium; Male; Nitric Oxide; Random Allocation; Shock, Septic; Streptococcal Infections; Streptococcus pyogenes; Survival Rate; Swine; Thiourea

2000
Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
    Journal of inorganic biochemistry, 2000, Aug-31, Volume: 81, Issue:3

    Topics: Binding Sites; Crystallography, X-Ray; Endothelium; Heme; Humans; Isothiuronium; Kinetics; Models, Molecular; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Thiourea

2000
Myoglobin: A scavenger of bioactive NO.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-16, Volume: 98, Issue:2

    Topics: Animals; Bradykinin; Coronary Circulation; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Isothiuronium; Magnetic Resonance Spectroscopy; Metmyoglobin; Mice; Mice, Knockout; Mitochondria, Heart; Models, Biological; Myocardial Contraction; Myocardium; Myoglobin; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Vasodilation; Vasodilator Agents

2001
Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Immunohistochemistry; Indazoles; Insulin; Isothiuronium; Male; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Ornithine; Rats; Rats, Wistar

2001
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 39, Issue:2 Pt 2

    Topics: Animals; Enzyme Inhibitors; Female; Hemodynamics; Isothiuronium; Kidney; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley

2002
Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice.
    Journal of pharmacological sciences, 2003, Volume: 91, Issue:1

    Topics: Animals; Anxiety; Carotid Arteries; Enzyme Inhibitors; Exploratory Behavior; Indazoles; Interpersonal Relations; Ischemic Attack, Transient; Isothiuronium; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I

2003
Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts.
    Circulation research, 2003, Jun-27, Volume: 92, Issue:12

    Topics: Adenosine Triphosphate; Animals; Arginine; Carbon Dioxide; Carbon Monoxide; Enzyme Inhibitors; Genotype; Heart; In Vitro Techniques; Isothiuronium; Magnetic Resonance Spectroscopy; Metmyoglobin; Mice; Mice, Transgenic; Myocardial Contraction; Myocardium; Myoglobin; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrogen; Oxygen; Perfusion; Phosphocreatine; Ventricular Pressure

2003
Deferoxamine reduces and nitric oxide synthase inhibition increases neutrophil-mediated myotube injury.
    Cell and tissue research, 2003, Volume: 313, Issue:3

    Topics: Catalase; CD18 Antigens; Chromium; Chromium Radioisotopes; Culture Media, Conditioned; Deferoxamine; Humans; Hydroxyl Radical; Iron Chelating Agents; Isothiuronium; Luminescent Measurements; Muscle Fibers, Skeletal; Neutrophils; Nitric Oxide Synthase; Reactive Oxygen Species; Superoxide Dismutase

2003
Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia.
    Cardiovascular research, 2007, Apr-01, Volume: 74, Issue:1

    Topics: Animals; Biomarkers; Extracellular Fluid; Isothiuronium; Microdialysis; Microscopy, Confocal; Mitochondria, Heart; Models, Animal; Myocardial Ischemia; Myocardial Reperfusion; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Oxyhemoglobins; Staining and Labeling; Swine; Swine, Miniature

2007
Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Adrenal Medulla; Animals; Bombesin; Brain; Catecholamines; Cycloheximide; Cyclooxygenase 1; Indazoles; Isothiuronium; Ketoprofen; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrobenzenes; Rats; Rats, Wistar; Sulfonamides

2008