Page last updated: 2024-09-05

isospaglumic acid and phenobarbital sodium

isospaglumic acid has been researched along with phenobarbital sodium in 25 studies

Compound Research Comparison

Studies (isospaglumic acid)	Trials (isospaglumic acid)	Recent Studies (post-2010) (isospaglumic acid)	Studies (phenobarbital sodium)	Trials (phenobarbital sodium)	Recent Studies (post-2010) (phenobarbital sodium)
469	31	116	85	0	29

Protein Interaction Comparison

Protein	Taxonomy	phenobarbital sodium (IC50)
Cytochrome P450 3A4	Homo sapiens (human)	0.0011
Cytochrome P450 2B6	Homo sapiens (human)	0.0011
Glutamate carboxypeptidase 2	Rattus norvegicus (Norway rat)	0.0027
Glutamate carboxypeptidase 2	Homo sapiens (human)	0.0196

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	16 (64.00)	29.6817
2010's	7 (28.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barinka, C; Hlouchová, K; Konvalinka, J; Lubkowski, J; Majer, P; Mlcochová, P; Plechanovová, A; Rovenská, M; Slusher, BS; Tsukamoto, T	1
Bhardwaj, A; Britton, P; Harukuni, I; Hurn, PD; Jackson, PF; Lu, XC; Potter, BM; Robinson, MB; Slusher, BS; Thomas, AG; Tortella, FC; Traystman, RJ; Vornov, JJ; Wozniak, KM; Yudkoff, M	1
Jackson, P; Lu, M; Slusher, B; Tsukamoto, T; Vornov, JJ; Wang, E; Wozniak, K	1
Nozaki-Taguchi, N; Sakashita, Y; Yamamoto, T	1
Olkowski, JL; Slusher, BS; Thomas, AG	1
Gafurov, B; Grossfeld, RM; Lieberman, EM; Urazaev, AK	1
Buttram, JG; Deen, JP; Gafurov, BS; Grossfeld, RM; Lieberman, EM; Slusher, BS; Urazaev, AK	1
Cai, Z; Lin, S; Rhodes, PG	1
Kozikowski, AP; Neale, JH; Rong, SB; Wang, S; Wroblewski, JT; Zhang, J	1
Flanary, J; Frazier, ST; Rojas, C; Slusher, BS	1
Carpenter, KJ; Dickenson, AH; Flatters, SL; Matthews, EA; Sen, S; Slusher, BS; Wozniak, KM	1
Berent-Spillson, A; Golovoy, D; Robinson, AM; Rojas, C; Russell, JW; Slusher, B	1
Calvin, D; Rojas, C; Slusher, BS; Thomas, AG; Tsukamoto, T; Vornov, J; Wozniak, KM; Wu, Y	1
Belozertseva, I; Bespalov, A; Danysz, W; Eilbacher, B; Greco, S; Jirgensons, A; Kashkin, V; Malyshkin, A; Nagel, J; Shekunova, E	1
Bergeron, R; Coyle, JT; Frangioni, JV; Greene, RW; Imamura, Y	1
Czuczwar, SJ; Kamiński, RM; Lukawski, K	1
Kozikowski, A; Neale, JH; Yamamoto, T; Zhou, J	1
Ashby, CR; Chun, L; Gardner, EL; Li, J; Li, X; Peng, XQ; Slusher, BS; Thomas, AG; Xi, ZX	1
Bodner, A; Ghadge, G; Roos, RP; Slusher, BS; Thomas, AG	1
Alt, J; Barker, PB; Brandt, J; Calabresi, PA; Crainiceau, CM; Grishkan, I; Kaplin, AI; Pletnikov, MV; Pomper, MG; Rahn, KA; Rais, R; Rojas, C; Slusher, BS; Stathis, M; Watkins, CC	1
Blechová, M; Březinová, A; Konvalinka, J; Šácha, P; Šafařík, M; Šebestík, J; Sedlák, F	1
Cheong, YH; Jo, SA; Kim, H; Kim, MJ; Lee, SK; Park, SI; Youn, HS	1
Chen, H; Flora, MN; Guo, H; Liu, J; McCabe, JT; McDonough, JH; Myers, TM; Van Shura, K	1
Alt, J; Hollinger, KR; Kaplin, AI; Riehm, AM; Slusher, BS	1
Cannella, LA; Gregg, RA; Hicks, C; Nayak, SU; Rawls, SM; Reitz, AB; Schena, GJ; Smith, GR; Tallarida, CS	1

Reviews

1 review(s) available for isospaglumic acid and phenobarbital sodium

Article	Year
Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Analgesics; Animals; Aspartic Acid; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Molecular Structure; Neurons; Neuroprotective Agents; Organophosphorus Compounds	2006

Other Studies

24 other study(ies) available for isospaglumic acid and phenobarbital sodium

Article	Year
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14 Topics: Crystallography, X-Ray; Glutamate Carboxypeptidase II; Humans; Models, Molecular; Molecular Mimicry; Protein Conformation; Recombinant Proteins	2007
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nature medicine, 1999, Volume: 5, Issue:12 Topics: Animals; Brain Ischemia; Carboxypeptidases; Culture Techniques; Dipeptides; Disease Models, Animal; Drug Tolerance; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Ischemic Attack, Transient; Mice; Mice, Inbred ICR; Neuroprotective Agents; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Stroke	1999
Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG. Annals of the New York Academy of Sciences, 1999, Volume: 890 Topics: Animals; Carboxypeptidases; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Organophosphorus Compounds; Rats; Reperfusion Injury	1999
Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat. Brain research, 2001, Aug-03, Volume: 909, Issue:1-2 Topics: Animals; Carboxypeptidases; Carrageenan; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Hindlimb; Hyperalgesia; Inflammation; Male; Neural Inhibition; Nociceptors; Organophosphorus Compounds; Pain; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission	2001
Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation. European journal of pharmacology, 2001, Aug-24, Volume: 426, Issue:1-2 Topics: Animals; Benzoates; Carboxypeptidases; Cells, Cultured; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Neuroglia; Neuroprotective Agents; Organophosphorus Compounds; Rats; Receptors, Metabotropic Glutamate	2001
N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber. Neuroscience, 2001, Volume: 106, Issue:1 Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carboxypeptidases; Cell Communication; Cysteic Acid; Dipeptides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nervous System; Neuroglia; Organophosphorus Compounds; Receptors, Glutamate; Signal Transduction; Time Factors	2001
Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling. Neuroscience, 2001, Volume: 107, Issue:4 Topics: Animals; Astacoidea; Carboxypeptidases; Cell Communication; Cell Membrane; Cytoplasm; Dipeptides; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamate Carboxypeptidase II; Nerve Fibers; Neuroglia; Organophosphorus Compounds; Signal Transduction; Tritium	2001
Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia. European journal of pharmacology, 2002, Feb-22, Volume: 437, Issue:3 Topics: Amino Acids; Animals; Animals, Newborn; Brain; Carboxypeptidases; Cyclic AMP; Cycloleucine; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Hippocampus; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Organophosphorus Compounds; Propionates; Rats; Rats, Sprague-Dawley; Xanthenes	2002
Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Amino Acid Sequence; Carboxypeptidases; Dipeptides; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutarates; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphorus Compounds; Phosphinic Acids; Sequence Homology, Amino Acid; Static Electricity; Structure-Activity Relationship	2002
Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay. Analytical biochemistry, 2002, Nov-01, Volume: 310, Issue:1 Topics: Binding, Competitive; Carboxypeptidases; Catalysis; Chromatography, Ion Exchange; Dipeptides; Hydrolysis; Kinetics; Microchemistry; Organophosphorus Compounds; Scintillation Counting; Tritium	2002
Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat. Neuropeptides, 2003, Volume: 37, Issue:5 Topics: Animals; Carrageenan; Dipeptides; Disease Models, Animal; Electric Stimulation; Glutamate Carboxypeptidase II; Ligation; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neuritis; Nociceptors; Organophosphorus Compounds; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Nerves	2003
Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3. Journal of neurochemistry, 2004, Volume: 89, Issue:1 Topics: Animals; Apoptosis; Cells, Cultured; Coculture Techniques; Diabetic Neuropathies; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glucose; Glutamate Carboxypeptidase II; Neurites; Neurons; Neuroprotective Agents; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schwann Cells	2004
Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration. Neuropharmacology, 2006, Volume: 51, Issue:7-8 Topics: Analgesics, Non-Narcotic; Animals; Biotransformation; Blood-Brain Barrier; Brain Chemistry; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Extracellular Fluid; Glutamate Carboxypeptidase II; Injections, Intraperitoneal; Ligation; Male; Microdialysis; Models, Animal; Neuralgia; Neuroprotective Agents; Organophosphorus Compounds; Pain Threshold; Pyridazines; Quinolines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate; Sciatic Nerve	2006
Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus. Journal of neurochemistry, 2007, Volume: 100, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Antibodies; Chemokine CXCL6; Chemokines, CXC; Dipeptides; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Organophosphorus Compounds; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate	2007
Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks. European journal of pharmacology, 2008, Jan-28, Volume: 579, Issue:1-3 Topics: Animals; Avoidance Learning; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glutamate Carboxypeptidase II; Maze Learning; Memory; Mice; Motor Activity; Organophosphorus Compounds	2008
Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. Molecular pain, 2008, Aug-01, Volume: 4 Topics: Analgesics; Animals; Dipeptides; Glutamate Carboxypeptidase II; Inflammation Mediators; Injections, Intraventricular; Male; Organophosphorus Compounds; Pain; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Urea	2008
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. Journal of neurochemistry, 2010, Volume: 112, Issue:2 Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Extinction, Psychological; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Microdialysis; Microinjections; Neuroprotective Agents; Nucleus Accumbens; Organophosphorus Compounds; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Self Administration; Sucrose; Sweetening Agents	2010
GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. Journal of neurovirology, 2009, Volume: 15, Issue:5-6 Topics: AIDS Dementia Complex; Animals; Apoptosis; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Hippocampus; HIV Envelope Protein gp120; Neuroglia; Neurons; Neuroprotective Agents; Organophosphorus Compounds; Rats; Receptors, Metabotropic Glutamate; Transforming Growth Factor beta	2009
Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 2012, Dec-04, Volume: 109, Issue:49 Topics: Adult; Analysis of Variance; Animals; Cognitive Dysfunction; Dipeptides; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Glutamate Carboxypeptidase II; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuropsychological Tests; Organophosphorus Compounds	2012
Glutamate carboxypeptidase II does not process amyloid-β peptide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:7 Topics: Amyloid beta-Peptides; Antigens, Surface; Biocatalysis; Catalytic Domain; Chromatography, High Pressure Liquid; Dipeptides; Glutamate Carboxypeptidase II; Humans; Hydrolysis; Mass Spectrometry; Molecular Structure; Neprilysin; Organophosphorus Compounds; Peptide Fragments; Proteolysis; Recombinant Proteins; Substrate Specificity; Tritium	2013
S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation. Biochemical and biophysical research communications, 2013, Sep-06, Volume: 438, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Cell Line, Tumor; Dipeptides; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Mice; Mice, Transgenic; Molecular Docking Simulation; Mutagenesis, Site-Directed; Organophosphorus Compounds; Proteolysis	2013
N-acetyl-aspartyl-glutamate and inhibition of glutamate carboxypeptidases protects against soman-induced neuropathology. Neurotoxicology, 2015, Volume: 48 Topics: Animals; Brain; Carboxypeptidases; Cell Death; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Male; Neurons; Neuroprotective Agents; Organophosphate Poisoning; Organophosphorus Compounds; Rats, Sprague-Dawley; Signal Transduction; Soman; Time Factors	2015
Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis. Brain research, 2016, Mar-15, Volume: 1635 Topics: Animals; Aspartic Acid; Cognition Disorders; Dipeptides; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Glutamate Carboxypeptidase II; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Organophosphorus Compounds; Severity of Illness Index	2016
Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG). Psychopharmacology, 2017, Volume: 234, Issue:11 Topics: Alkaloids; Amino Acids; Animals; Benzodioxoles; Conditioning, Psychological; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Male; Organophosphorus Compounds; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reward; Synthetic Cathinone; Xanthenes	2017