isospaglumic acid has been researched along with kainic acid in 12 studies
| Studies (isospaglumic acid) | Trials (isospaglumic acid) | Recent Studies (post-2010) (isospaglumic acid) | Studies (kainic acid) | Trials (kainic acid) | Recent Studies (post-2010) (kainic acid) |
|---|---|---|---|---|---|
| 469 | 31 | 116 | 9,540 | 3 | 1,775 |
| Protein | Taxonomy | isospaglumic acid (IC50) | kainic acid (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 4.2857 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 0.0126 | |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 3 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 4 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 5 | Homo sapiens (human) | 0.077 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 0.0126 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sekiguchi, M; Wada, K; Wenthold, RJ | 1 |
| Garyaev, AP; Piotrovsky, LB; Poznyakova, LN | 1 |
| Blakely, RD; Coyle, JT; Robinson, MB; Thompson, RC | 1 |
| Orrego, F; Riveros, N | 1 |
| Coyle, JT; Koller, KJ; Zaczek, R | 1 |
| Lancaster, J; Neale, JH; Sweetnam, PM; Valivullah, HM | 1 |
| Burlina, AB; Burlina, AP; Ferrari, V; Leon, A; Mazza, MR; Skaper, SD | 1 |
| Comair, YG; Hong, SC; Lüders, HO; Najm, IM; Ng, TC; Wang, Y | 1 |
| Akaike, N; Harata, N; Katayama, J | 1 |
| Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F | 1 |
| Russell, JW; Spillson, AB | 1 |
| Borst, P; de Haas, M; Jansen, RS; Mahakena, S; van de Wetering, K | 1 |
12 other study(ies) available for isospaglumic acid and kainic acid
| Article | Year |
|---|---|
N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cloning, Molecular; Dipeptides; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transcription, Genetic; Xenopus laevis | 1992 |
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.
Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1991 |
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny, and the effect of lesions on N-acetylated-alpha-linked acidic dipeptidase activity.
Topics: Animals; Brain; Cell Membrane; Cerebral Cortex; Corpus Striatum; Dipeptidases; Dipeptides; Glutamate Carboxypeptidase II; Hydrolysis; Kainic Acid; Kidney; Kinetics; Neural Pathways; Rats; Synaptosomes; Tissue Distribution | 1988 |
A study of possible excitatory effects of N-acetylaspartylglutamate in different in vivo and in vitro brain preparations.
Topics: Animals; Brain; Calcium; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Rats; Receptors, Cell Surface; Receptors, Kainic Acid; Stimulation, Chemical; Thalamic Nuclei | 1984 |
N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method.
Topics: Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Dipeptides; Hippocampus; Kainic Acid; Liver; Male; Myocardium; Rats; Rats, Inbred Strains; Spinal Cord; Tissue Distribution | 1984 |
Interactions between N-acetylaspartylglutamate and AMPA, kainate, and NMDA binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Dipeptides; Drug Interactions; Kainic Acid; N-Methylaspartate; Prosencephalon; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1994 |
N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.
Topics: Animals; Aspartic Acid; Canavan Disease; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dipeptides; Kainic Acid; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons | 1994 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuropeptides; Protons; Rats; Rats, Sprague-Dawley; Seizures; Temporal Lobe | 1997 |
Excitatory amino acid responses in relay neurons of the rat lateral geniculate nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Glycine; Ionophores; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Nystatin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2001 |
Metabotropic glutamate receptor regulation of neuronal cell death.
Topics: Animals; Bacterial Proteins; Caspase 3; Caspases; Cell Death; Cells, Cultured; Dipeptides; Dizocilpine Maleate; DNA-Binding Proteins; Drug Interactions; Embryo, Mammalian; Ganglia, Spinal; Glucose; Glutamates; In Situ Nick-End Labeling; Indicators and Reagents; Kainic Acid; Neurons; Oxidative Stress; Proline; Rats; Receptors, Metabotropic Glutamate; Repressor Proteins; Schwann Cells; Time Factors | 2003 |
ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs.
Topics: Animals; Brain; Dipeptides; Humans; Kainic Acid; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nerve Tissue Proteins; Urea | 2015 |