Page last updated: 2024-09-05

isospaglumic acid and glutamic acid

isospaglumic acid has been researched along with glutamic acid in 97 studies

Compound Research Comparison

Studies (isospaglumic acid)	Trials (isospaglumic acid)	Recent Studies (post-2010) (isospaglumic acid)	Studies (glutamic acid)	Trials (glutamic acid)	Recent Studies (post-2010) (glutamic acid)
469	31	116	41,757	452	12,876

Protein Interaction Comparison

Protein	Taxonomy	glutamic acid (IC50)
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	Rattus norvegicus (Norway rat)	0.821
Chain A, Glutamate Receptor Subunit 2	Rattus norvegicus (Norway rat)	0.821
Chain B, Glutamate Receptor Subunit 2	Rattus norvegicus (Norway rat)	0.821
Metabotropic glutamate receptor 8	Homo sapiens (human)	0.0057
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	0.07
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	0.07
Glutamate receptor 1	Rattus norvegicus (Norway rat)	0.5885
Glutamate receptor 2	Rattus norvegicus (Norway rat)	0.5885
Glutamate receptor 3	Rattus norvegicus (Norway rat)	0.5885
Glutamate receptor 4	Rattus norvegicus (Norway rat)	0.5885
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	0.38
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	0.1533
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	0.38
Glutamate receptor 1	Homo sapiens (human)	0.613
Glutamate receptor 2	Homo sapiens (human)	0.613
Glutamate receptor 3	Homo sapiens (human)	0.613
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	0.38
Excitatory amino acid transporter 1	Homo sapiens (human)	207
Glutamate receptor 4	Homo sapiens (human)	0.613
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	0.1533
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	0.1533
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	0.1533
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	0.38
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	0.07
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	0.07
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	0.07
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	0.07
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	0.1533
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	0.38
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	0.07
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	0.1533
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	0.1533

Research

Studies (97)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (11.34)	18.7374
1990's	21 (21.65)	18.2507
2000's	33 (34.02)	29.6817
2010's	28 (28.87)	24.3611
2020's	4 (4.12)	2.80

Authors

Authors	Studies
Barinka, C; Hlouchová, K; Konvalinka, J; Lubkowski, J; Majer, P; Mlcochová, P; Plechanovová, A; Rovenská, M; Slusher, BS; Tsukamoto, T	1
Neale, JH; Williamson, LC	2
Chillemi, F; Rubino, FM; Zecca, L	1
Sekiguchi, M; Wada, K; Wenthold, RJ	1
Bixler, MA; Coyle, JT; Koller, KJ; Meyerhoff, JL; Robinson, MB	1
Carter, RE; Coyle, JT; Meyerhoff, JL; Slusher, BS; Yourick, DL	1
Garyaev, AP; Piotrovsky, LB; Poznyakova, LN	1
Coyle, JT; Hedreen, JC; Kuncl, R; Rothstein, JD; Sim, L; Stauch-Slusher, B; Tsai, GC	1
Artaud, F; Chéramy, A; Desce, JM; Galli, T; Glowinski, J; Godeheu, G	1
Brancati, A; D'Arcangelo, P	1
Okamoto, K; Sakai, Y; Sekiguchi, M	1
Koerner, JF; Whittemore, ER	1
Carpenter, DO; Coyle, JT; Ffrench-Mullen, JM; Hori, N; Koller, K; Zaczek, R	1
Coyle, JT; Koller, KJ	2
Blakely, RD; Coyle, JT; Ory-Lavollée, L; Thompson, RC	1
Mori-Okamoto, J; Okamoto, K; Sekiguchi, M	1
Cangro, CB; Corigliano-Murphy, A; Namboodiri, MA; Neale, JH; Sklar, LA	1
Perl, ER; Schneider, SP	1
Orrego, F; Riveros, N	1
Holburn, GE; Lee, H; Martin, PR; Price, RR; Tarter, J; Weinstein, DD	1
Neale, JH; Saab, OH; Wroblewska, B; Wroblewski, JT	1
Cassidy, M; Neale, JH	2
Bischofberger, J; Schild, D	1
Bhakoo, KK; Florian, CL; Noble, MD; Williams, SR	1
Neale, JH; Pshenichkin, S; Sullivan, SE; Surin, A; Wroblewska, B; Wroblewski, JT	1
Liptaj, T; Mierisová, S; Tkác, I; van den Boogaart, A; Van Hecke, P; Vanhamme, L	1
Bolo, N; Dahchour, A; De Witte, P; Durbin, P; Macher, JP; Muzet, M; Nédélec, JF	1
Akaike, N; Harata, N; Katayama, J	1
Bhardwaj, A; Britton, P; Harukuni, I; Hurn, PD; Jackson, PF; Lu, XC; Potter, BM; Robinson, MB; Slusher, BS; Thomas, AG; Tortella, FC; Traystman, RJ; Vornov, JJ; Wozniak, KM; Yudkoff, M	1
Jackson, P; Lu, M; Slusher, B; Tsukamoto, T; Vornov, JJ; Wang, E; Wozniak, K	1
Barker, GJ; Duncan, JS; McLean, MA; Woermann, FG	1
Barker, GJ; Bartlett, PA; Duncan, JS; McLean, MA; Woermann, FG	1
Jackson, PF; Slusher, BS	1
Fletcher, PL; Gafurov, BSh; Grossfeld, RM; Lieberman, EM; Urazaev, AKh	1
Gafurov, B; Grossfeld, RM; Lieberman, EM; Urazaev, AK	1
Buttram, JG; Fletcher, PL; Gafurov, BS; Grossfeld, RM; Lieberman, EM; Speno, H; Urazaev, AK	1
Gafurov, BS; Grossfeld, RM; Lieberman, EM; Urazaev, AK	1
Berkman, CE; Hosaka, M; Kamga, I; Ng, R	1
Bernsen, H; Boerman, R; Heerschap, A; Rijpkema, M; Schuuring, J; van der Graaf, M; van der Kogel, A; van der Meulen, Y	1
Campbell, GA; Ezell, EL; Matalon, R; Michals-Matalon, K; Quast, MJ; Rady, PL; Rassin, DK; Surendran, S; Szucs, S; Tyring, SK; Wei, J	1
Balcar, VJ; Bubeníková, V; Fitzgibbon, T; Pliss, L; Pokorný, J; St'astný, F	1
Hurd, R; Nelson, SJ; Pelletier, D; Sailasuta, N; Srinivasan, R; Vigneron, DB	1
Bzdega, T; Gehl, LM; Neale, JH; Saab, OH; Wroblewska, B	1
Juchem, C; Logothetis, NK; Merkle, H; Nauerth, A; Pfeuffer, J	1
Ambrosini, A; Colonnese, C; Garreffa, G; Giove, F; Guardati, M; Macrì, MA; Maraviglia, B	1
Minabe, Y; Ogino, T; Shirayama, Y; Takahashi, S	1
Tsai, SJ	1
Dunham, SA; Knight-Scott, J; Shanbhag, DD	1
Altmann, DR; Chard, DT; Davies, G; Griffin, CM; McLean, MA; Miller, DH; Rashid, W; Sastre-Garriga, J; Thompson, AJ; Tiberio, M	1
Berman, RF; Bzdega, T; Jiang, J; Kozikowski, AP; Lyeth, BG; Neale, JH; O'Connor, WT; Smyth, A; Van, KC; Zhao, X; Zhong, C; Zhou, J	1
Matalon, R; Michals-Matalon, K; Surendran, S; Tyring, SK	1
Achreja, M; Lieberman, EM; Urazaev, AK	1
Calvin, D; Rojas, C; Slusher, BS; Thomas, AG; Tsukamoto, T; Vornov, J; Wozniak, KM; Wu, Y	1
Connor, JR; Ill, AM; Mitchell, TR; Neely, EB	1
Barinka, C; Eckschlager, T; Hilgert, I; Hlouchová, K; Konvalinka, J; Mlcochová, P; Sácha, P; Vícha, A; Zámecník, J	1
Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ	1
Baker, EH; Barker, PB; Basso, G; Bonekamp, D; Horská, A; Smith, MA	1
Danielsen, ER; Dock, J; Elberling, TV; Feldt-Rasmussen, U; Hørding, M; Perrild, H; Rasmussen, AK; Thomsen, C; Waldemar, G	1
Barker, GJ; Duncan, JS; McLean, MA; Salmenpera, TM; Simister, RJ	1
Atkins, A; Dawson, LA; de la Flor, R; Shah, AJ; Slone-Murphy, J	1
Attwell, D; Hamilton, NB; Káradóttir, R; Kolodziejczyk, K; Wade, A	1
Ende, G; Hoerst, M; Meyer-Lindenberg, A; Tunc-Skarka, N; Weber-Fahr, W; Zink, M	1
Canta, A; Carozzi, VA; Cavaletti, G; Chiorazzi, A; Lapidus, RG; Slusher, BS; Wozniak, KM	1
Ashby, CR; Chun, L; Gardner, EL; Li, J; Li, X; Peng, XQ; Slusher, BS; Thomas, AG; Xi, ZX	1
Artal, J; Fayed, N; Modrego, PJ; Olmos, S	1
Igarashi, H; Nakada, T; Nishizawa, M; Okamoto, K; Ozawa, T; Shimohata, T; Takado, Y; Terajima, K	1
Clark, VP; Coffman, BA; Gasparovic, C; Trumbo, MC	1
Bacci, A; Feraco, P; Leonardi, M; Malavolta, N; Passamonti, L; Pedrabissi, F; Zampogna, G	1
Rowland, LM	1
Fei, S; Ji, Y; Rao, S; Wang, H; Yao, X; Zeng, M	1
Bao, Y; Guo, J; Liu, C; Lu, X; Niu, B; Wang, F; Wang, J; Wang, L; Wu, L; Xie, H; Zhang, T; Zhao, H; Zou, J	1
Raiteri, L; Raiteri, M; Romei, C	1
Barker, PB; Edden, RA; Holcomb, HH; Kontson, K; Rowland, LM; West, J; Wijtenburg, SA; Zhu, H	1
Chang, S; Feusner, JD; Gorbis, E; Levitt, JG; Maidment, KM; O'Neill, J; Ringman, JM; Salamon, N; Saxena, S; Yip, JC	1
Horita, DA; Kleven, GA; Morgan, JJ; Olson, J; Ronca, AE; Tulbert, CD	1
Cheong, YH; Jo, SA; Kim, H; Kim, MJ; Lee, SK; Park, SI; Youn, HS	1
Fievisohn, EM; Hardy, WN; Sajja, VS; Vandevord, PJ	1
Auer, MK; Bidlingmaier, M; Biedermann, SV; Bielohuby, M; Deussing, J; Ende, G; Falfán-Melgoza, C; Fuss, J; Gass, P; Jakovcevski, M; Lenz, JN; Pfister, F; Sack, M; Stalla, GK; Steinle, J; Weber-Fahr, W	1
Bogorodzki, P; Gaździńska, A; Gazdzinski, SP; Janeczko, K; Karwowska, K; Kossowski, B; Majka, P; Orzeł, J; Osoba, JJ; Setkowicz, Z; Wyleżoł, M	1
Castellano, G; Covolan, RJ; Edden, RA; Foerster, B; Landim, RC; Li, LM	1
Barker, PB; Brandt, AS; Churchill, G; Edden, RA; Harris, AD; Hua, J; Lim, IA; Margolis, RL; Pradhan, S; Ross, CA; Unschuld, PG; van Zijl, PC	1
Farah, MH; Hollinger, KR; Jackson, PF; Majer, P; Rais, R; Slusher, BS; Vornov, JJ; Wozniak, KM	1
Bergeron, R; Khacho, P; Wang, B	1
Bairwa, D; Das, BK; Jagannathan, NR; Kumar, V; Pandey, RM; Sharma, SK; Sinha, S; Srivastava, AK; Vyas, S	1
Deelchand, DK; Grant, A; Hemmy, LS; Hodges, J; Marjańska, M; McCarten, JR; Terpstra, M	1
Barbieri, MA; Cavalli, RC; Del-Ben, CM; Figueiredo, FP; Rosa, CE; Salmon, CEG; Santos, AC; Schaufelberger, MS; Soares, JC	1
Chen, Y; Gao, W; Li, Q; Liu, S; Liu, W; Shen, Z; Wu, R; Zhang, G	1
Brooks, SJ; Burger, A; Howells, FM; Stein, DJ	1
Barker, PB; Coughlin, JM; Crawford, JL; DuBois, SL; Nestadt, G; Nucifora, FC; Nucifora, LG; Pradhan, S; Sawa, A; Schretlen, DJ; Sedlak, TW; Trivedi, A; Wang, AM	1
Abdelkefi, I; Dhamala, E; Hennessy, TJ; Nadeau, H; Near, J; Nguyen, M	1
Andronesi, O; Bogner, W; Dydak, U; Ma, RE; Murdoch, JB	1
González-Mora, JL; Jiménez-Espinoza, C; Marcano Serrano, F	1
Morland, C; Nordengen, K	1
Bourcier, T; Choual, I; de Blay, F; Domis, N; Gherasim, A	1

Reviews

6 review(s) available for isospaglumic acid and glutamic acid

Article	Year
Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia. Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:9 Topics: Animals; Aspartic Acid; Brain; Dipeptides; Glutamic Acid; Humans; Models, Neurological; Receptors, N-Methyl-D-Aspartate; Schizophrenia	2005
Canavan disease: studies on the knockout mouse. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Amidohydrolases; Animals; Canavan Disease; Dipeptides; gamma-Aminobutyric Acid; Gene Targeting; Genetic Therapy; Glutamic Acid; Humans; Mice; Mice, Knockout; Phenotype; Stem Cell Transplantation	2006
Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Analgesics; Animals; Aspartic Acid; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Molecular Structure; Neurons; Neuroprotective Agents; Organophosphorus Compounds	2006
Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors. Advances in pharmacology (San Diego, Calif.), 2016, Volume: 76 Topics: Animals; Antigens, Surface; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Neuroglia; Neurotransmitter Agents	2016
The Good and Bad Sides of NAAG. Advances in pharmacology (San Diego, Calif.), 2016, Volume: 76 Topics: Animals; Brain; Dipeptides; Glutamic Acid; HEK293 Cells; Humans; Neurodegenerative Diseases; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate	2016
International journal of molecular sciences, 2022, Jan-23, Volume: 23, Issue:3 Topics: Animals; Brain; Brain Diseases; Brain Injuries, Traumatic; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Mental Disorders; Neurodegenerative Diseases; Neurons; Neurotransmitter Agents; Receptors, Metabotropic Glutamate	2022

Trials

7 trial(s) available for isospaglumic acid and glutamic acid

Article	Year
Central effects of acamprosate: part 2. Acamprosate modifies the brain in-vivo proton magnetic resonance spectrum in healthy young male volunteers. Psychiatry research, 1998, May-20, Volume: 82, Issue:2 Topics: Acamprosate; Adult; Alcohol Deterrents; Aspartic Acid; Brain; Creatine; Cross-Over Studies; Dipeptides; Double-Blind Method; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Taurine	1998
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter. Magnetic resonance in medicine, 2000, Volume: 44, Issue:3 Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Phantoms, Imaging; Regression Analysis; Sensitivity and Specificity	2000
Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy. Brain : a journal of neurology, 2001, Volume: 124, Issue:Pt 2 Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Malformations; Phosphocreatine; Reference Values	2001
Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging. NMR in biomedicine, 2003, Volume: 16, Issue:1 Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Oligodendroglioma; Reproducibility of Results; Sensitivity and Specificity	2003
Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0-T magnetic resonance spectroscopy study. Movement disorders : official journal of the Movement Disorder Society, 2011, Volume: 26, Issue:7 Topics: Aged; Aspartic Acid; Biomarkers; Choline; Creatinine; Dipeptides; Feasibility Studies; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Multiple System Atrophy; Pons; Protons; Severity of Illness Index	2011
Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:9 Topics: Adult; Aspartic Acid; Choline; Chronic Pain; Creatinine; Dipeptides; Female; Fibromyalgia; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Thalamus	2011
Efficacy of N-acetyl aspartyl glutamic acid versus fluorometholone for treating allergic conjunctivitis in an environmental exposure chamber. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2022, Volume: 52, Issue:9 Topics: Allergens; Conjunctivitis, Allergic; Cross-Over Studies; Dipeptides; Environmental Exposure; Fluorometholone; Glutamic Acid; Humans; Mast Cell Stabilizers	2022

Other Studies

84 other study(ies) available for isospaglumic acid and glutamic acid

Article	Year
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14 Topics: Crystallography, X-Ray; Glutamate Carboxypeptidase II; Humans; Models, Molecular; Molecular Mimicry; Protein Conformation; Recombinant Proteins	2007
Uptake, metabolism, and release of N-[3H]acetylaspartylglutamate by the avian retina. Journal of neurochemistry, 1992, Volume: 58, Issue:6 Topics: Animals; Aspartic Acid; Biological Transport; Chickens; Dipeptides; Glutamates; Glutamic Acid; Glutamine; Histamine H1 Antagonists; Retina; Time Factors; Tritium	1992
Characterization of putative neurotransmitter N-acetyl-aspartyl-glutamic acid and some related compounds by fast atom bombardment and tandem mass spectrometry. Biological mass spectrometry, 1992, Volume: 21, Issue:2 Topics: Amino Acid Sequence; Aspartic Acid; Brain Chemistry; Dipeptides; Glutamates; Glutamic Acid; Mass Spectrometry; Molecular Sequence Data; Neurotransmitter Agents; Spectrometry, Mass, Fast Atom Bombardment	1992
N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes. FEBS letters, 1992, Oct-26, Volume: 311, Issue:3 Topics: 2-Amino-5-phosphonovalerate; Animals; Cloning, Molecular; Dipeptides; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transcription, Genetic; Xenopus laevis	1992
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase. Epilepsy research. Supplement, 1992, Volume: 8 Topics: Amygdala; Animals; Aspartic Acid; Brain; Brain Mapping; Dipeptidases; Dipeptides; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamates; Glutamic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Seizures	1992
Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate. Brain research, 1992, Oct-09, Volume: 593, Issue:1 Topics: Animals; Brain; Cell Membrane; Dipeptidases; Dipeptides; Epilepsy; Glutamate Carboxypeptidase II; Glutamates; Glutamic Acid; Male; Neuropeptides; Organ Specificity; Rats; Rats, Mutant Strains; Reference Values	1992
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice. Neuroscience letters, 1991, Apr-29, Volume: 125, Issue:2 Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Seizures; Structure-Activity Relationship	1991
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain research, 1991, Aug-09, Volume: 556, Issue:1 Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Humans; Motor Cortex; Reference Values; Spinal Cord	1991
Presynaptic facilitation of dopamine release through D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors on synaptosomes from the rat striatum. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dipeptides; Dopamine; Glutamates; Glutamic Acid; Ibotenic Acid; Male; Nerve Endings; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptosomes; Tritium	1991
Distribution of N-acetylaspartate, N-acetylaspartylglutamate, free glutamate and aspartate following complete mesencephalic transection in rat neuraxis. Neuroscience letters, 1990, Jun-22, Volume: 114, Issue:1 Topics: Animals; Aspartic Acid; Brain Chemistry; Brain Stem; Cerebellum; Dipeptides; Glutamates; Glutamic Acid; Male; Mesencephalon; Rats; Rats, Inbred Strains; Reference Values; Spinal Cord	1990
Release of endogenous N-acetylaspartylglutamate (NAAG) and uptake of [3H]NAAG in guinea pig cerebellar slices. Brain research, 1989, Mar-13, Volume: 482, Issue:1 Topics: Animals; Cerebellum; Dipeptides; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques	1989
An explanation for the purported excitation of piriform cortical neurons by N-acetyl-L-aspartyl-L-glutamic acid (NAAG). Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:23 Topics: Animals; Bronchodilator Agents; Central Nervous System; Cerebral Cortex; Dipeptides; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neurons; Olfactory Pathways; Potassium Chloride; Rats; Rats, Inbred Strains	1989
N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:11 Topics: Animals; Aspartic Acid; Central Nervous System; Dipeptides; Electrophysiology; Glutamates; Glutamic Acid; Neurons; Neurotransmitter Agents; Olfactory Pathways; Rats; Rats, Inbred Strains	1985
The characterization of the specific binding of [3H]-N-acetylaspartylglutamate to rat brain membranes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:11 Topics: Animals; Binding, Competitive; Brain; Calcium; Dipeptides; Glutamates; Glutamic Acid; Guanine Nucleotides; Ibotenic Acid; Kinetics; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Serine; Sodium; Synaptosomes; Tissue Distribution	1985
Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. Journal of neurochemistry, 1986, Volume: 47, Issue:4 Topics: Amino Acids; Animals; Biological Transport; Brain; Dipeptides; Glutamates; Glutamic Acid; Kinetics; Male; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Sodium; Synaptosomes; Tritium	1986
Electrophysiological and pharmacological actions of N-acetylaspartylglutamate intracellularly studied in cultured chick cerebellar neurons. Brain research, 1987, Jan-13, Volume: 401, Issue:1 Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Cerebellum; Chick Embryo; Dipeptides; Electric Conductivity; Glutamates; Glutamic Acid; Magnesium	1987
Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia. Journal of neurochemistry, 1987, Volume: 49, Issue:5 Topics: Amino Acids; Animals; Anisomycin; Aspartic Acid; Chromatography, High Pressure Liquid; Cycloheximide; Dipeptides; Ganglia; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; Histocytochemistry; Immunologic Techniques; Male; Neurons; Rats; Rats, Inbred Strains	1987
Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1988, Volume: 8, Issue:6 Topics: Afferent Pathways; Amino Acids; Animals; Aspartic Acid; Cricetinae; Dipeptides; Electrophoresis; Glutamates; Glutamic Acid; Male; Mesocricetus; Neurons; Spinal Cord	1988
Calcium-dependent release of N-acetylaspartylglutamate from retinal neurons upon depolarization. Brain research, 1988, Dec-13, Volume: 475, Issue:1 Topics: Animals; Calcium; Dipeptides; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Potassium; Ranidae; Retina	1988
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors. European journal of pharmacology, 1984, Feb-17, Volume: 98, Issue:2 Topics: Animals; Binding Sites; Brain; Calcium; Cerebral Cortex; Chlorides; Dipeptides; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Glutamate	1984
A study of possible excitatory effects of N-acetylaspartylglutamate in different in vivo and in vitro brain preparations. Brain research, 1984, May-14, Volume: 299, Issue:2 Topics: Animals; Brain; Calcium; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Rats; Receptors, Cell Surface; Receptors, Kainic Acid; Stimulation, Chemical; Thalamic Nuclei	1984
In vivo localized proton NMR spectroscopy of thiamine-deficient rat brain. Magnetic resonance in medicine, 1995, Volume: 34, Issue:3 Topics: Alcohol Amnestic Disorder; Animals; Brain; Creatine; Dipeptides; Dose-Response Relationship, Drug; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats; Rats, Sprague-Dawley; Thiamine; Thiamine Deficiency; Wernicke Encephalopathy	1995
N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. Journal of neurochemistry, 1993, Volume: 61, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Dipeptides; Glutamates; Glutamic Acid; Granulocytes; Inositol Phosphates; Receptors, Glutamate	1993
Localization and transport of N-acetylaspartylglutamate in cells of whole murine brain in primary culture. Journal of neurochemistry, 1993, Volume: 60, Issue:5 Topics: Animals; Biological Transport; Brain; Cells, Cultured; Dipeptides; Glutamates; Glutamic Acid; Immunohistochemistry; Mice; Neuroglia; Neurons; Protease Inhibitors; Radioimmunoassay; Temperature; Tissue Distribution	1993
N-acetylaspartylglutamate catabolism is achieved by an enzyme on the cell surface of neurons and glia. Neuropeptides, 1993, Volume: 24, Issue:5 Topics: Animals; Brain; Cells, Cultured; Dipeptidases; Dipeptides; Extracellular Space; Female; Glutamates; Glutamic Acid; Membrane Proteins; Mice; Nerve Tissue Proteins; Neuroglia; Neurons; Neuropeptides; Pregnancy	1993
Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor. Journal of neurophysiology, 1996, Volume: 76, Issue:3 Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Cyclopropanes; Dipeptides; Glutamic Acid; Glycine; Homovanillic Acid; Interneurons; Ion Channel Gating; Olfactory Bulb; Receptors, Metabotropic Glutamate; Synapses; Xenopus	1996
Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography. Neurochemical research, 1996, Volume: 21, Issue:9 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Callosum; Dipeptides; Eye; gamma-Aminobutyric Acid; Glutamic Acid; Hydrogen; Magnetic Resonance Spectroscopy; Olfactory Bulb; Oligodendroglia; Optic Nerve; Organ Specificity; Rats; Stem Cells	1996
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. Journal of neurochemistry, 1997, Volume: 69, Issue:1 Topics: Animals; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Histamine H1 Antagonists; Humans; Hydrolysis; Kidney; Neuropeptides; Neuroprotective Agents; Phosphates; Rats; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Transfection	1997
New approach for quantitation of short echo time in vivo 1H MR spectra of brain using AMARES. NMR in biomedicine, 1998, Volume: 11, Issue:1 Topics: Algorithms; Animals; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Magnetic Resonance Imaging; Male; Rats; Rats, Wistar; Software; Time Factors	1998
Excitatory amino acid responses in relay neurons of the rat lateral geniculate nucleus. Neuroscience, 1999, Volume: 89, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Glycine; Ionophores; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Nystatin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	1999
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nature medicine, 1999, Volume: 5, Issue:12 Topics: Animals; Brain Ischemia; Carboxypeptidases; Culture Techniques; Dipeptides; Disease Models, Animal; Drug Tolerance; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Ischemic Attack, Transient; Mice; Mice, Inbred ICR; Neuroprotective Agents; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Stroke	1999
Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG. Annals of the New York Academy of Sciences, 1999, Volume: 890 Topics: Animals; Carboxypeptidases; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Organophosphorus Compounds; Rats; Reperfusion Injury	1999
Design of NAALADase inhibitors: a novel neuroprotective strategy. Current medicinal chemistry, 2001, Volume: 8, Issue:8 Topics: Animals; Carboxylic Acids; Carboxypeptidases; Dipeptides; Drug Design; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Ischemia; Neuroprotective Agents; Phosphinic Acids; Phosphorus; Receptors, Metabotropic Glutamate; Structure-Activity Relationship	2001
[Synthesis and release of N-acetylaspartyl glutamate (NAAG) in medial giant axons in crayfish]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2001, Volume: 87, Issue:4 Topics: Action Potentials; Axons; Carboxypeptidases; Cell Membrane; Chromatography, High Pressure Liquid; Dipeptides; Electric Stimulation; Enzyme Inhibitors; Extracellular Space; Ganglia, Invertebrate; Glutamate Carboxypeptidase II; Glutamic Acid; Hydrolysis; In Vitro Techniques; Neuroglia	2001
N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber. Neuroscience, 2001, Volume: 106, Issue:1 Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carboxypeptidases; Cell Communication; Cysteic Acid; Dipeptides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nervous System; Neuroglia; Organophosphorus Compounds; Receptors, Glutamate; Signal Transduction; Time Factors	2001
Synthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: implications for axon-glia signaling. Neuroscience, 2001, Volume: 106, Issue:1 Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carbon Radioisotopes; Carboxypeptidases; Cell Communication; Culture Media; Cytoplasm; Dipeptides; Electric Stimulation; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Glutamine; Nervous System; Neuroglia; Organ Culture Techniques; Quisqualic Acid; Signal Transduction; Tritium	2001
Mechanism of NMDA receptor contribution to axon-to-glia signaling in the crayfish medial giant nerve fiber. Glia, 2002, Apr-01, Volume: 38, Issue:1 Topics: Acetylcholine; Animals; Astacoidea; Axons; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Communication; Cell Membrane; Dipeptides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Membrane Potentials; Nervous System; Neural Conduction; Neuroglia; Nicotinic Antagonists; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Sodium	2002
High-performance liquid chromatography method for detecting prostate-specific membrane antigen activity. Analytical biochemistry, 2002, Nov-01, Volume: 310, Issue:1 Topics: Antigens, Neoplasm; Antigens, Surface; Carboxypeptidases; Cell Membrane; Chromatography, High Pressure Liquid; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Hydrolysis; Male; Prostatic Neoplasms; Tritium; Tumor Cells, Cultured	2002
Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease. Brain research bulletin, 2003, Aug-30, Volume: 61, Issue:4 Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Azo Compounds; Brain Chemistry; Canavan Disease; Creatine; Dipeptides; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Insect Proteins; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, Protein	2003
Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate. Neuroscience, 2003, Volume: 122, Issue:1 Topics: Animals; Aspartic Acid; Cell Count; Cell Death; Dipeptides; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neuropeptides; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors	2003
Measurement of brain glutamate using TE-averaged PRESS at 3T. Magnetic resonance in medicine, 2004, Volume: 51, Issue:3 Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Dipeptides; Female; Fourier Analysis; Glutamic Acid; Glutamine; Humans; Image Enhancement; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropeptides; Reproducibility of Results	2004
Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia. Journal of neurochemistry, 2004, Volume: 90, Issue:4 Topics: Animals; Aspartic Acid; Cells, Cultured; Central Nervous System; Cerebellum; Cerebral Cortex; Culture Media, Serum-Free; Dipeptides; Enzymes; Glutamic Acid; Glutamine; Neuroglia; Neurons; Potassium Chloride; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Spinal Cord; Tritium	2004
High-field localized 1H NMR spectroscopy in the anesthetized and in the awake monkey. Magnetic resonance imaging, 2004, Volume: 22, Issue:10 Topics: Anesthesia, General; Animals; Artifacts; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dipeptides; Glutamic Acid; Glutamine; Glutathione; Hydrogen; Image Enhancement; Inositol; Lactic Acid; Macaca mulatta; Magnetic Resonance Spectroscopy; Phosphocreatine; Stereoisomerism; Taurine; Wakefulness	2004
In vivo quantitative 1H MRS of cerebellum and evaluation of quantitation reproducibility by simulation of different levels of noise and spectral resolution. Magnetic resonance imaging, 2004, Volume: 22, Issue:10 Topics: Adult; Artifacts; Aspartic Acid; Body Water; Cerebellum; Choline; Creatine; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Image Enhancement; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropeptides	2004
In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats. Journal of neurochemistry, 2005, Volume: 92, Issue:6 Topics: Amino Acids; Amygdala; Animals; Creatine; Dipeptides; Disease Models, Animal; Energy Metabolism; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glycine; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Magnetic Resonance Spectroscopy; Male; Neural Pathways; Rats; Rats, Wistar; Up-Regulation	2005
A phase rotation scheme for achieving very short echo times with localized stimulated echo spectroscopy. Magnetic resonance imaging, 2005, Volume: 23, Issue:8 Topics: Adult; Algorithms; Brain; Choline; Creatine; Dipeptides; Female; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Phantoms, Imaging; Reference Values; Time Factors	2005
Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study. Journal of neurology, 2006, Volume: 253, Issue:2 Topics: Adult; Aspartic Acid; Choline; Creatine; Dipeptides; Female; Follow-Up Studies; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Statistics, Nonparametric; Time Factors	2006
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. Journal of neurochemistry, 2006, Volume: 97, Issue:4 Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Up-Regulation	2006
Synthesis of N-acetylaspartyl-glutamate (NAAG) and N-acetylaspartate (NAA) in axons and glia of the crayfish medial giant nerve fiber. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Animals; Aspartic Acid; Astacoidea; Axons; Dipeptides; Glutamic Acid; Nerve Fibers; Neuroglia	2006
Metabolic analysis of mouse brains that have compromised iron storage. Metabolic brain disease, 2006, Volume: 21, Issue:2-3 Topics: Animals; Brain Chemistry; Cerebral Cortex; Choline; Dipeptides; Ferritins; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Iron Metabolism Disorders; Magnetic Resonance Spectroscopy; Mice; Neostriatum; Principal Component Analysis	2006
Expression of glutamate carboxypeptidase II in human brain. Neuroscience, 2007, Feb-23, Volume: 144, Issue:4 Topics: Aged; Aged, 80 and over; Antibodies; Antigens, Surface; Astrocytes; Blotting, Western; Brain; Dipeptides; Enzyme Activation; Epitope Mapping; Female; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Immunohistochemistry; Male; Middle Aged; Models, Molecular; Protein Structure, Tertiary; Radioligand Assay; Recombinant Fusion Proteins	2007
The effect of sodium valproate on proton MRS visible neurochemical concentrations. Epilepsy research, 2007, Volume: 74, Issue:2-3 Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Valproic Acid	2007
Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla. Journal of magnetic resonance imaging : JMRI, 2008, Volume: 27, Issue:3 Topics: Adult; Age Factors; Aspartic Acid; Brain Chemistry; Choline; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male	2008
Reduced parietooccipital white matter glutamine measured by proton magnetic resonance spectroscopy in treated graves' disease patients. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:8 Topics: Adult; Aspartic Acid; Choline; Dipeptides; Female; Glutamic Acid; Glutamine; Graves Disease; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Parietal Lobe; Prospective Studies	2008
The effect of epileptic seizures on proton MRS visible neurochemical concentrations. Epilepsy research, 2008, Volume: 81, Issue:1 Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Data Interpretation, Statistical; Dipeptides; Female; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Protons; Seizures	2008
Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Dec-15, Volume: 876, Issue:2 Topics: Animals; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Dipeptides; Glutamic Acid; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2008
The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain : a journal of neurology, 2009, Volume: 132, Issue:Pt 6 Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Canavan Disease; Cerebellum; Dipeptides; Evoked Potentials; Glutamic Acid; Hydrolysis; Oligodendroglia; Patch-Clamp Techniques; Pelizaeus-Merzbacher Disease; Rats; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques	2009
MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia. NeuroImage, 2009, Nov-15, Volume: 48, Issue:3 Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Dipeptides; Female; Frontal Lobe; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Fibers, Myelinated; Phosphocreatine; Protons; Schizophrenia; Water	2009
Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat. Neurotoxicity research, 2010, Volume: 17, Issue:4 Topics: Animals; Antineoplastic Agents; Body Weight; Carboxypeptidases; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Female; Ganglia, Spinal; Glutamic Acid; Neuroprotective Agents; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Statistics, Nonparametric	2010
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. Journal of neurochemistry, 2010, Volume: 112, Issue:2 Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Extinction, Psychological; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Microdialysis; Microinjections; Neuroprotective Agents; Nucleus Accumbens; Organophosphorus Compounds; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Self Administration; Sucrose; Sweetening Agents	2010
Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson disease. Academic radiology, 2011, Volume: 18, Issue:2 Topics: Aged; Brain; Choline; Corpus Striatum; Creatine; Diffusion Tensor Imaging; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Parkinson Disease; Severity of Illness Index; Substantia Nigra	2011
Transcranial direct current stimulation (tDCS) produces localized and specific alterations in neurochemistry: a ¹H magnetic resonance spectroscopy study. Neuroscience letters, 2011, Aug-01, Volume: 500, Issue:1 Topics: Adult; Aspartic Acid; Brain; Cerebrum; Dipeptides; Electric Stimulation; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Young Adult	2011
Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues. Biological psychiatry, 2011, Sep-01, Volume: 70, Issue:5 Topics: Animals; Depressive Disorder, Major; Diffusion Tensor Imaging; Dipeptides; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Stress, Psychological	2011
Metabolite detection of pancreatic carcinoma by in vivo proton MR spectroscopy at 3T: initial results. La Radiologia medica, 2012, Volume: 117, Issue:5 Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Choline; Dipeptides; Fatty Acids, Unsaturated; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pancreatic Neoplasms; Software	2012
Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population. Metabolic brain disease, 2012, Volume: 27, Issue:1 Topics: Adult; Anencephaly; Asian People; Aspartic Acid; Case-Control Studies; China; Dipeptides; Encephalocele; Female; Folic Acid; Gene Frequency; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Neural Tube Defects; Polymorphism, Genetic; Risk Factors; Spinal Dysraphism; Young Adult	2012
Glycine release is regulated by metabotropic glutamate receptors sensitive to mGluR2/3 ligands and activated by N-acetylaspartylglutamate (NAAG). Neuropharmacology, 2013, Volume: 66 Topics: Amino Acids; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Glycine; Male; Mice; Potassium Chloride; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptosomes; Xanthenes	2013
In vivo measurements of glutamate, GABA, and NAAG in schizophrenia. Schizophrenia bulletin, 2013, Volume: 39, Issue:5 Topics: Adult; Age Factors; Attention; Cerebrum; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Schizophrenia; Severity of Illness Index; Young Adult	2013
Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder. Journal of psychiatric research, 2013, Volume: 47, Issue:4 Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Cognitive Behavioral Therapy; Dipeptides; Follow-Up Studies; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurochemistry; Obsessive-Compulsive Disorder; Pilot Projects; Severity of Illness Index	2013
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development. NMR in biomedicine, 2013, Volume: 26, Issue:6 Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Prosencephalon; Rats; Rats, Sprague-Dawley; Taurine	2013
S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation. Biochemical and biophysical research communications, 2013, Sep-06, Volume: 438, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Cell Line, Tumor; Dipeptides; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Mice; Mice, Transgenic; Molecular Docking Simulation; Mutagenesis, Site-Directed; Organophosphorus Compounds; Proteolysis	2013
Evaluation of impact-induced traumatic brain injury in the Göttingen Minipig using two input modes. Traffic injury prevention, 2014, Volume: 15 Suppl 1 Topics: Animals; Aspartic Acid; Brain Injuries; Dipeptides; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Swine; Swine, Miniature	2014
Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Mar-31, Volume: 35, Issue:4 Topics: Animals; Aspartic Acid; Brain; Carbohydrate Metabolism; Diet; Dipeptides; Energy Intake; Fatty Acids; Glucose; Glutamic Acid; Hyperglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Obesity; Physical Conditioning, Animal; Protons; Running	2015
Does Long-Term High Fat Diet Always Lead to Smaller Hippocampi Volumes, Metabolite Concentrations, and Worse Learning and Memory? A Magnetic Resonance and Behavioral Study in Wistar Rats. PloS one, 2015, Volume: 10, Issue:10 Topics: Animals; Body Weight; Diet, High-Fat; Dipeptides; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory Disorders; Obesity; Organ Size; Rats, Wistar; Spatial Memory	2015
Investigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experiment. Magnetic resonance imaging, 2016, Volume: 34, Issue:3 Topics: Adult; Aspartic Acid; Brain; Dipeptides; Female; Glutamic Acid; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Neuropeptides; Vision, Ocular; Young Adult	2016
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla. Schizophrenia research, 2016, Volume: 172, Issue:1-3 Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gyrus Cinguli; Humans; Inositol; Male; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia	2016
Case control study: magnetic resonance spectroscopy of brain in HIV infected patients. BMC neurology, 2016, Jul-12, Volume: 16 Topics: Adult; Aspartic Acid; Basal Ganglia; Case-Control Studies; Choline; Creatine; Dipeptides; Female; Frontal Lobe; Glutamic Acid; Glutamine; HIV Infections; Humans; Inositol; Lipid Metabolism; Macromolecular Substances; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Proton Magnetic Resonance Spectroscopy; White Matter	2016
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using Neuroscience, 2017, 06-23, Volume: 354 Topics: Aged; Aged, 80 and over; Aging; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Creatine; Dipeptides; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Phosphocreatine; Tritium; Young Adult	2017
Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy. Psychiatry research. Neuroimaging, 2017, Jul-30, Volume: 265 Topics: Adult; Aspartic Acid; Depression, Postpartum; Dipeptides; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy	2017
Copper chloride dose-dependently alters spatial learning and memory, and glutamate levels, in the hippocampus of rats. Molecular medicine reports, 2018, Volume: 17, Issue:3 Topics: Animals; Aspartic Acid; Brain Chemistry; Copper; Dipeptides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory; Phosphocreatine; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley	2018
The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study. Drug and alcohol dependence, 2018, 04-01, Volume: 185 Topics: Adolescent; Adult; Amphetamine-Related Disorders; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Methamphetamine; Neurons; Proton Magnetic Resonance Spectroscopy; Young Adult	2018
Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis. JAMA psychiatry, 2019, 03-01, Volume: 76, Issue:3 Topics: Aspartic Acid; Brain; Case-Control Studies; Cross-Sectional Studies; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Male; Neuropsychological Tests; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Young Adult	2019
Validation of in vivo MRS measures of metabolite concentrations in the human brain. NMR in biomedicine, 2019, Volume: 32, Issue:3 Topics: Aspartic Acid; Brain; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Humans; Magnetic Resonance Spectroscopy; Male; Metabolome; Young Adult	2019
Atlas-based GABA mapping with 3D MEGA-MRSI: Cross-correlation to single-voxel MRS. NMR in biomedicine, 2021, Volume: 34, Issue:5 Topics: Adult; Creatinine; Dipeptides; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Young Adult	2021
Molecules (Basel, Switzerland), 2021, Jan-28, Volume: 26, Issue:3 Topics: Adult; Aspartic Acid; Astrocytes; Autism Spectrum Disorder; Biomarkers; Cerebral Cortex; Dipeptides; Female; Glutamic Acid; Humans; Male; Neurons; Oligodendroglia; Proton Magnetic Resonance Spectroscopy; Young Adult	2021