isosorbide dinitrate has been researched along with nitrates in 269 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 170 (63.20) | 18.7374 |
| 1990's | 56 (20.82) | 18.2507 |
| 2000's | 32 (11.90) | 29.6817 |
| 2010's | 8 (2.97) | 24.3611 |
| 2020's | 3 (1.12) | 2.80 |
| Authors | Studies |
|---|---|
| Brix, W; Hochrein, H; Lehmann, HU | 1 |
| Schrey, A | 1 |
| Baitsch, G; Bertel, O; Burkart, F; Elsässer, S; Ritz, R | 1 |
| Conti, G; Del Guercio, R; Esposito, C; Leone, C | 1 |
| Murao, S; Uchida, Y; Yoshimoto, N | 1 |
| Ogawa, T; Rose, HB; Takano, TT; Vyden, JK | 1 |
| Goldstein, RE | 1 |
| Alimurung, B; Fletcher, GF; Watt, E | 1 |
| Preston, TA; Richtsmeier, TE | 1 |
| Abrams, J | 6 |
| Bogaert, MG; Rosseel, MT | 3 |
| Davidson, IW; Di Carlo, FJ; Parker, JC | 1 |
| Krantz, JC; Leake, CD | 1 |
| Behrenbeck, DW; Hilger, HH; Niehues, B; Tauchert, M | 1 |
| Needleman, P | 1 |
| Reichek, N | 1 |
| Dacian, S; Dirschinger, J; Fleck, E; Loracher, C; Rudolph, W | 1 |
| Kupersmith, J | 1 |
| Baligadoo, S; Barritault, L; Chiche, P | 1 |
| Thaler, H | 1 |
| Batlouni, M; Duprat, R; Hoxter, G; Meneghelo, RS | 1 |
| Chasseaud, LF; Down, WH; Grundy, RK | 1 |
| Lydtin, H; Trenkwalder, P | 1 |
| Schmid, M; Yeates, RA | 1 |
| Hamer, AW | 1 |
| Bartsch, W; Neidlein, R; Pressmar, F; Strein, K | 1 |
| Werkö, L | 1 |
| Kuhn, M | 1 |
| Feelisch, M; Noack, E | 1 |
| Henry, PJ; Horowitz, JD; Louis, WJ | 1 |
| Aldershvile, J; Boesgaard, S; Grande, P; Madsen, JK; Pedersen, F; Pietersen, A | 1 |
| Fung, HL; Tzeng, TB | 2 |
| Parker, JO | 4 |
| Holzmann, S; Kukovetz, WR | 3 |
| Beyerle, A; Lehmann, G; Reiniger, G; Rudolph, W; Wolf, H | 1 |
| Baldenkov, GN; Mazaev, AV; Mukharliamov, NM; Negrescu, EV; Sazonova, LN; Tkachuk, VA | 1 |
| Jonsson, UE | 2 |
| Silber, S | 2 |
| Dirschinger, J; Hall, D; Rudolph, W | 1 |
| Bennett, BM; McDonald, BJ | 1 |
| Noack, E | 1 |
| Bayeric, A; Dirschinger, J; Hall, D; Reiniger, G; Rudolph, W | 1 |
| Kots, IaI; Solonovich, TG | 1 |
| Engelmann, L; Frömmel, H; Kucher, A; Wetzler, G | 1 |
| Penkov, N; Sirakova, V | 1 |
| Lekkerkerker, JF | 1 |
| Ahlner, J; Axelsson, KL; Torfgård, K | 1 |
| Ivanov, I | 1 |
| Metelitsa, VI | 1 |
| Beyerle, A; Dirschinger, J; Reiniger, G; Rudolph, W | 1 |
| Hashimoto, H; Ito, T; Nakagawa, H; Ogawa, K; Okumura, K; Satake, T | 1 |
| Conti, CR | 1 |
| Holzmann, S; Kukovetz, WR; Romanin, C | 1 |
| Amtorp, O; Svendsen, JH | 1 |
| Bennett, A; Melhuish, PB; Stamford, IF | 1 |
| Kukovetz, WR; Romanin, C | 1 |
| Van Dyke, RW | 1 |
| Flaherty, JT | 1 |
| Jähnchen, E | 1 |
| Kaltenbach, M; Schneider, W | 2 |
| Larin, NV; Pakulin, IA; Semin, SN; Sil'vestrov, VP; Surovov, IuA | 1 |
| Berlin, R | 1 |
| Kampmann, JP | 1 |
| Jaeger, H; Lutz, D; Michaelis, K; Salama, ZB | 1 |
| Zeller, FP | 1 |
| Ahland, B; König, E; Schrör, K; Weiss, P | 1 |
| De Caterina, R; De Nes, M; L'Abbate, A; Marzilli, M; Michelassi, C; Simonetti, I | 1 |
| Bernini, W; De Caterina, R; Giannessi, D; Mazzone, A | 1 |
| Farrell, B; Lahey, KA; Parker, JO; Rose, BF | 1 |
| Blasini, R; Reiniger, G; Rudolph, W | 1 |
| Aberg, A; Aström, H; Carlens, P; Lindström, E; Lundman, T; Nordlander, R; Nyberg, G; Rehnqvist, N; Ulvenstam, G | 1 |
| Krause, KH; Silber, S; Theisen, K; Vogler, AC | 1 |
| Erhardt, E; Stoss, P | 1 |
| Boertz, A; Bonn, R | 1 |
| De Caterina, R; Dorso, CR; Tack-Goldman, K; Weksler, BB | 1 |
| Beck, OA | 1 |
| Grosswendt, J; Klütsch, K; Koch, E; Schöniger, F | 1 |
| Luomanmäki, K | 1 |
| Offerhaus, L | 1 |
| Kokurina, EV; Martsevich, SIu; Metelitsa, VI; Piotrovskiĭ, VK | 1 |
| Fung, HL | 2 |
| Rietbrock, N | 1 |
| Fink, GB; Stipe, AA | 1 |
| Keyriläinen, O; Nyberg, G; Uusitalo, AJ | 1 |
| Hastings, SG | 1 |
| Epstein, SE; Goldstein, RE | 1 |
| Messini, M | 1 |
| Lazar, M; Leopold, IH; Wisznia, KI | 1 |
| Gautieri, RF; Ward, CO | 1 |
| Blum, SW; Hefner, MA; Howe, BB; Quinn, JB; Winbury, MM | 1 |
| Gioffré, PA; Motolese, M; Nigri, A; Reale, A | 1 |
| Campbell, RC; Catley, PF; Livesley, B; Oram, S | 1 |
| Kaufman, HE; Waltman, SR; West, C; Wood, TO | 1 |
| Klaus, AP; Pitt, BL; Ross, RS; Zaret, BL | 1 |
| Hayden, PW; Laurence, KM; Shurtleff, DB; Weeks, R | 1 |
| Wendt, RL | 1 |
| Cohn, KE; Selzer, A; Strauss, G; Sweatman, T | 1 |
| Johnson, EM; Lang, S; Needleman, P | 1 |
| Blehm, DJ; Harkey, AB; Johnson, EM; Needleman, P | 1 |
| Bogaert, MG | 2 |
| Aronow, WS | 1 |
| Kaye, H; Mills, B; Winsor, T | 1 |
| Gropper, E; Lachman, L; Shami, E; Tingstad, J | 1 |
| Belz, GG; Heesemann, E; Olesch, K | 1 |
| Strauer, BE | 1 |
| Adamska-Dyniewska, H; Chojnowska-Jezierska, J; Chojnowski, JR; Florczak, H; Mockallo, T | 1 |
| Alvarez, H; Battock, DJ; Chidsey, CA | 1 |
| Russek, HI | 2 |
| Harrison, DC | 1 |
| Cheng, TO | 1 |
| Mabuchi, G | 1 |
| Wendkos, MH | 1 |
| Gudbjarnason, S; Ogawa, K | 1 |
| Aronow, WS; Kaplan, MA | 3 |
| Aviado, DM; Bellet, S; Folle, LE | 1 |
| Aronow, WS; Chesluk, HM | 2 |
| Bermudez, GA; Butterfield, TK; Goldbarg, AN; Moran, JF; Nemickas, R | 1 |
| Bermudez, GA; Butterfield, TK; Goldbarg, AN; Morgan, JF; Nemickas, R | 1 |
| Semler, HJ | 1 |
| Evans, JM; Gorman, PA | 1 |
| Beiser, GD; Epstein, SE; Goldstein, RE; Redwood, DR; Rosing, DR | 1 |
| Nager, F | 1 |
| Orvis, HH; Semler, HJ | 1 |
| Leslie, RE | 1 |
| Da Costa, BC; Gensini, GG; Huntington, PP; Kelly, AE | 1 |
| Khan, MI; Regan, TJ; Senft, A; Weisse, AB | 1 |
| Hart, LG; May, JF; McCurdy, DH; Reed, DE | 1 |
| Dacosta, BC; Dubiel, J; Gensini, GG; Kelly, AE | 1 |
| Battock, DJ; Chidsey, CA | 1 |
| Giusti, C | 1 |
| Klepzig, H; Willems, D | 2 |
| Chandrakar, MP; Chatterji, AN; Jain, SR; Sepaha, GC | 1 |
| Kleinberg, S; Marcus, M; Sherber, DA | 1 |
| Levy, JV | 1 |
| Ruelius, HW; Sisenwine, SF | 1 |
| Hadzović, S; Nesić, L; Stern, P | 1 |
| Berry, JN; Bidwai, PS; Khattri, HN; Vohra, RK | 1 |
| Feigl, EO | 1 |
| Beller, BM | 1 |
| Dietz, AJ | 1 |
| Osnes, JB | 1 |
| Bassenge, E; Busse, R | 1 |
| Bar-Meir, S; Bardan, E; Halpern, Z | 1 |
| Feely, J; Maclean, D | 1 |
| Fung, HL; Kamiya, A; Sutton, SC | 1 |
| Arsura, E; Greengart, A; Guadagnino, V; Hollander, G; Lichstein, E; Nicchi, V; Sanders, M | 1 |
| Thadani, U | 2 |
| Abshagen, U; Dietmann, K; Sponer, G; Strein, K | 1 |
| Richardson, PJ; Timmis, AD | 1 |
| Haase, W; Marten, W; Weiss, M | 1 |
| Martsevich, SIu; Metelitsa, VI; Shakarova, SSh; Strel'tsov, AA; Vygodin, VA | 1 |
| Fukuzaki, H; Kobayashi, K; Yamabe, H | 1 |
| de Caterina, R; de Nes, M; L'Abbate, A; Marzilli, M; Simonetti, I | 1 |
| Rietbrock, N; Woodcock, BG | 1 |
| Hochrein, H; Lehmann, HU | 1 |
| Kaltenbach, M | 1 |
| Chatterjee, K | 1 |
| Baligadoo, S; Chiche, P | 1 |
| Freeman, WR; Mandel, WJ; Peter, T | 1 |
| Iskandrian, AS; Kotler, MN; Segal, BL | 1 |
| Gasanova, AS; Serbin, VI | 1 |
| Biamino, G; Nöring, J | 1 |
| Bron, J; Sterk, GJ; Timmerman, H; van der Werf, JF | 1 |
| Bache, RJ; Duncker, DJ; Mizrahi, J | 1 |
| Held, P; Olsson, G | 1 |
| Kendall, MJ | 1 |
| Lipicky, RJ; Thadani, U | 1 |
| Cobbe, SM; Conkie, JA; Hutton, I; Oldroyd, KG; Pye, M | 1 |
| Ahlner, J; Torfgård, KE | 1 |
| Bauer, JA; Fung, HL | 1 |
| Fehske, W; Honikel, HJ | 1 |
| Berkenboom, G; de Cannière, D; Staroukine, M; Unger, P; Vachiery, JL | 1 |
| Kojda, G; Meyer, W; Noack, E | 1 |
| Snape, JR; White, GF | 1 |
| Hayes, PC; Jones, AL | 1 |
| Stepin, J | 1 |
| Brands, F; Feelisch, M; Kelm, M | 1 |
| Göçer, F; Kayaalp, SO; Tuncer, M; Yariş, E | 1 |
| Goto, Y; Haze, K; Hiramori, K; Miyazaki, S; Nonogi, H; Sumiyoshi, T | 1 |
| Bara, A; Busse, R; Mordvintcev, P; Mülsch, A; Vanin, A | 1 |
| Parker, JA | 1 |
| Aniya, Y; Ishii, C; Matsuzaki, T; Sakanashi, M; Suenaga, T; Uehara, N; Wada, N | 1 |
| Berdeaux, A; Dubois-Randé, JL; Ghaleh, B; Giudicelli, JF; Hittinger, L | 1 |
| Barsotti, G; Cereda, R; Chiaverini, F; Gromo, G; L'Abbate, A; Magnozzi, D; Mizrahi, J; Pelosi, G; Taddei, L; Trivella, MG | 1 |
| Cremonesi, P; Donà, G; Giuliani, P; Mizrahi, J; Passaro, A; Stella, P; Tursi, F | 1 |
| Bianchini, C; Boyce, M; Johnston, A; Sardina, M; Warrington, SJ | 1 |
| Arai, M; Aso, N; Hama, J; Ishikawa, K; Kamata, N; Kanamasa, K; Katori, Y; Kimura, A; Naito, T; Nakai, S; Ogawa, I; Oyaizu, M; Takenaka, T; Yabushita, H; Yamamoto, K; Yamamoto, T | 1 |
| Bruno, G; Cordovil, A; Dodi, C; Picano, E; Pingitore, A; Sicari, R | 1 |
| Parker, JD; Parker, JO | 1 |
| Bychkov, R; Gollasch, M; Haller, H; Luft, FC; Ried, C; Steinke, T | 1 |
| Czachurski, J; Seller, H; Zanzinger, J | 1 |
| Aerts, AJ; Dendale, P | 1 |
| Balkestein, EJ; Sardina, M; Spek, JJ; Struijker Boudier, HA; Van Bortel, LM | 1 |
| Waller, DG | 1 |
| Anderson, DJ; Bennett, BM; McGuire, JJ; Ratz, JD | 1 |
| Schwinger, RH | 1 |
| Gyllenhaal, O; Karlsson, A | 1 |
| Abete, P; Acanfora, D; Ferrara, N; Furgi, G; Iannuzzi, GL; Leosco, D; Longobardi, G; Nicolino, A; Pinna, G; Rengo, F | 1 |
| Ahn, YK; Bae, Y; Cho, JG; Cho, JH; Jeong, MH; Kang, JC; Kang, KT; Kim, KH; Kim, NH; Kim, SH; Lee, SH; Park, JC; Rhew, JY | 1 |
| Kośmicki, M | 1 |
| Hatanaka, T; Ihara, K; Katayama, K; Kodera, M; Koizumi, T | 1 |
| Funae, Y; Imaoka, S; Inoue, M; Minamiyama, Y; Okada, S; Takemura, S | 1 |
| Aviram, EE; Elhayani, A; Galai, N; Lifshitz, M; Paran, E; Peled, R; Reuveni, H; Sherf, M | 1 |
| Landmark, K | 1 |
| Adachi, H | 1 |
| Aizawa, Y; Hori, T; Ishibashi, T; Kubota, K; Matsubara, T; Mezaki, T; Nakamura, Y; Nasuno, A; Nishio, M; Ozaki, K; Tanaka, T; Tsuchida, K; Yamazoe, M | 1 |
| Minamiyama, Y; Nishino, Y; Okada, S; Takemura, S | 1 |
| Aerts, AJ | 1 |
| JAFFE, GV; McGUINNESS, BW | 1 |
| BUNN, WH; CHREMOS, AN | 1 |
| DALVI, CP; DATEY, KK | 1 |
| Funae, Y; Hai, S; Hirohashi, K; Minamiyama, Y; Okada, S; Takemura, S; Yamasaki, K | 1 |
| Borovkova, NV; Chernov, VI; Demochko, AV; Idrisova, EM; Karpov, RS; Kladieva, EA; Shishkina, AA; Vorob'eva, EV | 1 |
| Cai, L; Chen, J; Gao, KP; Jiang, XG; Lu, W; Shi, ZQ; Zhang, QZ | 1 |
| Horowitz, JD | 1 |
| Harada, K; Iga, A; Ito, S; Kawano, T; Nakaya, Y; Nishikado, A; Nomura, M; Saito, K; Uehara, K; Uemura, E | 1 |
| Gori, T; Parker, JD | 1 |
| Hai, S; Hirohashi, K; Minamiyama, Y; Okada, S; Takemura, S; Yamasaki, K | 1 |
| Martsevich, SIu | 1 |
| Rodgers, T; Thadani, U | 1 |
| Shilov, AM | 1 |
| Cockcroft, JR; Mason, RP | 1 |
| Alvarez-Romero, GA; Palomar-Pardavé, ME; Ramírez-Silva, MT | 1 |
| Funae, Y; Imaoka, S; Minamiyama, Y; Okada, S; Takemura, S | 1 |
| Daiber, A; Münzel, T; Wenzel, P | 1 |
| Aydin, C; Bagcivan, I; Koyuncu, A; Sarac, B; Sarioglu, Y; Yildirim, S | 1 |
| Münzel, T | 1 |
| Daiber, A; Gori, T | 1 |
| Cooper, C; de Boer, A; de Vries, F; Lalmohamed, A; Leufkens, HG; Pouwels, S; Rejnmark, L; Souverein, P; van Staa, T; Vestergaard, P | 1 |
| Anderson, JE; Burczynski, FJ; Mizunoya, W; Upadhaya, R; Wang, G | 1 |
| Fabrizi, F; Galassi, F; Impagnatiello, F; Masini, E; Mincione, F; Scozzafava, G; Somma, T; Supuran, CT | 1 |
| Brooks, SC; Diercks, DB; Fermann, GJ; Kidney, R; McCabe, A; Pospisil, C; Salter, N; Seupaul, RA; Wakai, A | 1 |
| Bucur, RC; Cummings, SR; Hamilton, CJ; Jamal, SA; Reid, LS | 1 |
| Carresi, C; Dagostino, C; Giancotti, LA; Gliozzi, M; Gratteri, S; Malara, N; Mollace, V; Muscoli, C; Muscoli, S; Musolino, V; Palma, E; Romeo, F; Sacco, I; Salvemini, D; Visalli, V; Vitale, C | 1 |
| Kelly, JJ; Ong, SL; Whitworth, JA; Williamson, PM | 1 |
| Almirante, N; Bastia, E; Brambilla, S; Impagnatiello, F; Ravani, A; Storoni, L; Targa, M; Varani, K; Vincenzi, F | 1 |
| Guglin, M; Ilonze, OJ | 1 |
| Liu, W; Meng, Z; Wang, G | 1 |
| Akhtar, MF; Khan, MI; Riaz, A; Saleem, A; Sharif, H; Sharif, Z | 1 |
48 review(s) available for isosorbide dinitrate and nitrates
| Article | Year |
|---|---|
[Molsidomin compared to nitrates. Use in patients with manifest coronary disease].
Topics: Adrenergic beta-Antagonists; Aged; Calcium; Coronary Disease; Drug Evaluation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Morpholines; Nitrates; Nitroglycerin; Oxadiazoles; Sydnones | 1979 |
Organic nitrate metabolism.
Topics: Animals; Biodegradation, Environmental; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Isosorbide Dinitrate; Mice; Nitrates; Nitroglycerin; Oxidoreductases; Pentaerythritol Tetranitrate; Propylene Glycols; Rats; Time Factors | 1976 |
[Tolerance in treatment with nitrates].
Topics: Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Risk Factors | 1992 |
Nitrate tolerance--can it be prevented?
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates | 1991 |
Relationship between the inhibition of receptor-induced increase in cytosolic free calcium concentration and the vasodilator effects of nitrates in patients with congestive heart failure.
Topics: Adult; Blood Platelets; Calcium; Heart Failure; Humans; Isosorbide Dinitrate; Middle Aged; Nifedipine; Nitrates; Nitroglycerin; Nitroprusside; Plethysmography | 1990 |
Development of long-acting nitrate delivery systems.
Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
Nitrate tolerance. A problem during continuous nitrate administration.
Topics: Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Exercise; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
Nitrates: why and how should they be used today? Current status of the clinical usefulness of nitroglycerin, isosorbide dinitrate and isosorbide-5-mononitrate.
Topics: Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
[Nitrates in the treatment of heart failure].
Topics: Dose-Response Relationship, Drug; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
Mechanisms of nitrate tolerance--influence of the metabolic activation pathways.
Topics: Animals; Biotransformation; Coronary Disease; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
[Transdermal forms of nitrates].
Topics: Administration, Cutaneous; Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1989 |
[Long-term therapy with nitrates. How can continuous effectiveness be achieved?].
Topics: Administration, Cutaneous; Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Nitrates | 1989 |
Large vessel coronary vasospasm: diagnosis, natural history and treatment.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aspirin; Coronary Artery Bypass; Coronary Disease; Coronary Vasospasm; Diltiazem; Electrocardiography; Epoprostenol; Female; Fibrinolytic Agents; Humans; Isosorbide Dinitrate; Male; Nifedipine; Nitrates; Prazosin; Verapamil | 1985 |
Relationship between pharmacokinetics and pharmacodynamics of organic nitrates.
Topics: Angina Pectoris; Dose-Response Relationship, Drug; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate; Kinetics; Nitrates; Nitroglycerin | 1986 |
Pharmacokinetics of various preparations of organic nitrates.
Topics: Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Kinetics; Nitrates; Nitroglycerin | 1987 |
Tolerance to organic nitrates in ischemic heart disease.
Topics: Coronary Disease; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1987 |
Glyceryl trinitrate (nitroglycerin) and the organic nitrates. Choosing the method of administration.
Topics: Angina Pectoris; Heart Failure; Humans; Isosorbide Dinitrate; Myocardial Infarction; Nitrates; Nitroglycerin | 1987 |
Various administration forms of nitrates and their possibilities.
Topics: Administration, Cutaneous; Aerosols; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Kinetics; Nitrates | 1987 |
[Avoidance of tolerance development to long term therapy with nitrates through correct dosage].
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Kinetics; Nitrates | 1986 |
Efficacy of different forms of nitrates in angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Calcium; Drug Tolerance; Humans; Isosorbide Dinitrate; Kinetics; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Nucleotides, Cyclic; Ointments; Vasodilation | 1985 |
Pharmacology of nitroglycerin and long-acting nitrates.
Topics: Absorption; Administration, Oral; Administration, Topical; Angina Pectoris; Animals; Cheek; Delayed-Action Preparations; Drug Tolerance; Heart Failure; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Mouth Floor; Mouth Mucosa; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Vasodilator Agents | 1985 |
Nitrate formulations and drug delivery systems--an overview.
Topics: Animals; Biological Availability; Drug Tolerance; Isosorbide Dinitrate; Kinetics; Nitrates; Nitroglycerin; Rats | 1985 |
Editorial: Nitrates in the prophylactic treatment of angina pectoris.
Topics: Angina Pectoris; Exercise Test; Heart; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1973 |
Organic nitrates in angina pectoris.
Topics: Administration, Oral; Amyl Nitrite; Angina Pectoris; Blood Pressure; Coronary Circulation; Drug Tolerance; Heart Rate; Humans; Isosorbide Dinitrate; Mouth Floor; Muscle Contraction; Nitrates; Nitroglycerin; Oxygen Consumption; Physical Exertion; Vasodilator Agents | 1972 |
Some pharmacological properties of organic nitrates.
Topics: Angina Pectoris; Animals; Arterioles; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Drug Tolerance; Humans; Inactivation, Metabolic; Isosorbide Dinitrate; Liver; Muscle, Smooth, Vascular; Myocardium; Nitrates; Nitroglycerin; Oxyhemoglobins; Vasodilation; Venous Pressure | 1984 |
[Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation].
Topics: Adrenergic beta-Antagonists; Amyl Nitrite; Angina Pectoris; Animals; Blood Circulation; Calcium Channel Blockers; Humans; Isosorbide Dinitrate; Molsidomine; Muscle Contraction; Muscles; Nitrates; Nitroglycerin; Nitroprusside; Rats; Sydnones | 1982 |
Nitrate tolerance and dependence.
Topics: Ambulatory Care; Angina Pectoris; Animals; Cardiovascular Diseases; Dogs; Drug Tolerance; Heart Failure; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Occupational Medicine; Propranolol; Rabbits; Rats; Substance-Related Disorders; Time Factors | 1980 |
[Peripheral vasodilators in the treatment of heart failure].
Topics: Cardiac Output; Cardiomyopathies; Coronary Circulation; Droperidol; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Nitrates; Nitroprusside; Phentolamine; Piperazines; Prazosin; Quinazolines; Rheumatic Heart Disease; Stroke Volume; Vasodilator Agents | 1982 |
Short and long-acting oral nitrates for stable angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; United States; United States Food and Drug Administration; Vasodilator Agents | 1994 |
Clinical pharmacokinetics of nitrates.
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Administration Routes; Half-Life; Humans; Isosorbide Dinitrate; Liver; Nitrates; Nitroglycerin; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1994 |
Mechanisms of action of nitrates.
Topics: Angina Pectoris; Blood Platelets; Cyclic GMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Esterases; Glutathione Transferase; Heart; Heart Failure; Humans; Isosorbide Dinitrate; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Infarction; Nitrates; Nitroglycerin; Oxygen Consumption; Structure-Activity Relationship; Vasodilator Agents | 1994 |
Mechanisms of nitrate tolerance.
Topics: Angina Pectoris; Animals; Drug Administration Routes; Drug Therapy, Combination; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Sulfhydryl Compounds; Vascular Resistance | 1994 |
Nitrate therapy and the development of tolerance.
Topics: Angina Pectoris; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilator Agents | 1993 |
Microbial cleavage of nitrate esters: defusing the environment.
Topics: Biodegradation, Environmental; Collodion; Environmental Microbiology; Environmental Pollutants; Ethylene Glycols; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate | 1993 |
Organic nitrates in portal hypertension.
Topics: Animals; Collateral Circulation; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Nitrates; Nitroglycerin; Vasodilator Agents | 1994 |
Organic nitrates: new formulations and their clinical advantages.
Topics: Cardiovascular Diseases; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Randomized Controlled Trials as Topic | 1996 |
Nitrate therapy for stable angina pectoris.
Topics: Angina Pectoris; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Vasodilator Agents | 1998 |
Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate.
Topics: Angina Pectoris; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1999 |
[Is it worthwhile to treat stable angina pectoris with long-acting nitrates?].
Topics: Angina Pectoris; Chronic Disease; Coronary Disease; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 2000 |
Nitrate stimulated tilt table testing: a review of the literature.
Topics: Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Reproducibility of Results; Syncope, Vasovagal; Tilt-Table Test; Vasodilator Agents | 2003 |
[Nitrates. The place in contemporary therapy of ischemic heart disease].
Topics: Angina Pectoris; Contraindications; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Myocardial Infarction; Myocardial Ischemia; Nitrates; Nitroglycerin; Time Factors; Vasodilator Agents | 2005 |
Side effects of using nitrates to treat angina.
Topics: Angina Pectoris; Coronary Disease; Drug Interactions; Headache; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Phosphodiesterase Inhibitors; Randomized Controlled Trials as Topic; Syncope; Vasodilator Agents | 2006 |
[Nitrates in the practice of treatment of cardiovascular diseases].
Topics: Angina Pectoris; Cardiovascular Diseases; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 2006 |
Targeting nitric oxide with drug therapy.
Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzopyrans; Biological Availability; Calcium Channel Blockers; Carbazoles; Carvedilol; Ethanolamines; Heart Diseases; Humans; Isosorbide Dinitrate; Nebivolol; Neurodegenerative Diseases; Nicorandil; Nitrates; Nitric Oxide; Nitric Oxide Donors; Propanolamines; Vasodilator Agents | 2006 |
[Recent findings on nitrates: their action, bioactivation and development of tolerance].
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Coronary Disease; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Oxidative Stress; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Vasodilation; Vasodilator Agents | 2008 |
Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate.
Topics: Animals; Drug Administration Schedule; Drug Tolerance; Heart Diseases; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Oxidative Stress; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Vasodilator Agents | 2009 |
Nitrates for acute heart failure syndromes.
Topics: Acute Disease; Adult; Heart Failure; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Randomized Controlled Trials as Topic; Syndrome; Vasodilator Agents | 2013 |
The Efficacy of Nitrates for Bone Health: A Systematic Review and Meta-Analysis of Observational and Randomized Controlled Studies.
Topics: Bone and Bones; Bone Density; Female; Fractures, Bone; Humans; Isosorbide Dinitrate; Male; Nitrates; Nitric Oxide Donors; Nitroglycerin; Risk Factors | 2022 |
58 trial(s) available for isosorbide dinitrate and nitrates
| Article | Year |
|---|---|
Is the use of long acting nitrates beneficial in the patient with angina pectoris? (The positive side).
Topics: Administration, Oral; Angina Pectoris; Biological Availability; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Drug Stability; Electrocardiography; Heart Failure; Heart Rate; Humans; Isosorbide Dinitrate; Kinetocardiography; Myocardial Contraction; Nitrates; Nitroglycerin; Ointments; Oxygen Consumption; Vascular Resistance | 1977 |
Is the use of long acting nitrates beneficial in the patient with angina pectoris? (The negative side).
Topics: Angina Pectoris; Animals; Clinical Trials as Topic; Coronary Circulation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Inactivation, Metabolic; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1977 |
Acute drug testing with nitrates: angina relief during treadmill exercise.
Topics: Adult; Angina Pectoris; Drug Evaluation; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Physical Exertion | 1977 |
[1st symposium on nitrates].
Topics: Congresses as Topic; Coronary Disease; Humans; Isosorbide Dinitrate; Nitrates; Sweden | 1975 |
Placebo effect of nitrate monotherapy for myocardial ischemia.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nitrates; Placebo Effect | 1992 |
Continuous oral N-acetylcysteine treatment and development of nitrate tolerance in patients with stable angina pectoris.
Topics: Acetylcysteine; Administration, Oral; Aged; Angina Pectoris; Double-Blind Method; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Time Factors | 1991 |
[Effectiveness of various combination therapies in patients with coronary heart disease].
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Disease; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Hemodynamics; Humans; Isosorbide Dinitrate; Metoprolol; Nisoldipine; Nitrates | 1990 |
[Development and status of nitrate therapy in East Germany].
Topics: Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Germany, East; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardial Infarction; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Propylene Glycols; Vasodilator Agents | 1989 |
Mononitrates in combination with beta-blocker therapy in the treatment of severe angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Random Allocation | 1987 |
[Dose-response relationship of nitrate therapy of angina pectoris].
Topics: Administration, Cutaneous; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1986 |
Nitrate tolerance: the lack of effect of N-acetylcysteine.
Topics: Acetylcysteine; Administration, Oral; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Nitrates; Random Allocation; Time Factors | 1987 |
[Continuing anti-anginal effectiveness during chronic nitrate therapy in spite of the cessation of hemodynamic partial effects].
Topics: Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Placebos; Random Allocation; Time Factors | 1986 |
[Avoidance of tolerance development to long term therapy with nitrates through correct dosage].
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Kinetics; Nitrates | 1986 |
Tolerance to the hemodynamic and antianginal effects of the organic nitrates.
Topics: Administration, Oral; Administration, Topical; Angina Pectoris; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin | 1985 |
Prophylactic therapy of angina pectoris with organic nitrates: relationship of drug efficacy and clinical experimental design.
Topics: Angina Pectoris; Clinical Trials as Topic; Erythrityl Tetranitrate; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Placebos; Research Design; Time Factors | 1973 |
Effects of alprenolol and isosorbide dinitrate in angina pectoris. A comparative study with methodological considerations.
Topics: Activities of Daily Living; Adult; Aged; Alprenolol; Angina Pectoris; Electrocardiography; Female; Furans; Heart Function Tests; Humans; Isosorbide Dinitrate; Male; Methods; Middle Aged; Myocardial Infarction; Nitrates; Nitroglycerin; Physical Exertion; Placebos; Vasodilator Agents | 1973 |
Double-blind evaluation of verapamil, propranolol, and isosorbide dinitrate against a placebo in the treatment of angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Exercise Test; Female; Furans; Headache; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Placebos; Propranolol; Vasodilator Agents; Verapamil | 1973 |
Effect of isosorbide on intraocular pressure after penetrating keratoplasty.
Topics: Clinical Trials as Topic; Cornea; Diarrhea; Feeding and Eating Disorders; Furans; Humans; Intraocular Pressure; Isosorbide Dinitrate; Nitrates; Placebos; Vasodilator Agents; Vomiting | 1973 |
Comparative evaluation of sublingual long-acting nitrates.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Electrocardiography; Erythrityl Tetranitrate; Exercise Test; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Mouth Floor; Nitrates; Placebos; Propylene Glycols; Vasodilator Agents | 1973 |
Temporary treatment of hydrocephalus and myelodysplasia with isosorbide: preliminary report.
Topics: Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Cerebrospinal Fluid Proteins; Child; Clinical Trials as Topic; Feces; Furans; Head; Humans; Hydrocephalus; Infant; Infant, Newborn; Infections; Isosorbide Dinitrate; Nitrates; Placebos; Sodium; Spinal Cord Diseases | 1973 |
The long-acting hemodynamic effects of isosorbide dinitrate.
Topics: Angina Pectoris; Blood Pressure; Cardiac Output; Cardiac Volume; Exercise Test; Furans; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Placebos; Time Factors; Vascular Resistance; Vasodilator Agents | 1972 |
Hemodynamic response of oral long-acting nitrates: evidence of gastrointestinal absorption.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Blood Flow Velocity; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Female; Fingers; Furans; Humans; Intestinal Absorption; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitrates; Nitroglycerin; Placebos; Plethysmography; Pulse; Tablets; Vasodilator Agents | 1972 |
[Sorbonit in coronary disease].
Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates | 1968 |
Effects of propranolol and isosorbide dinitrate on exercise performance and adrenergic acitivity in patients with angina pectoris.
Topics: Adrenal Glands; Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Drug Synergism; Electrocardiography; Epinephrine; Exercise Test; Female; Furans; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitrates; Norepinephrine; Physical Exertion; Pituitary-Adrenal Function Tests; Placebos; Propranolol | 1969 |
New dimension in angina pectoris therapy.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Drug Synergism; Electrocardiography; Exercise Test; Female; Furans; Heart Rate; Humans; Ischemia; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitrates; Pentaerythritol Tetranitrate; Propranolol; Tachycardia | 1969 |
New drugs in the treatment of angina.
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Synergism; Furans; Heart Rate; Humans; Isosorbide Dinitrate; Nitrates; Placebos; Propranolol | 1969 |
Dilemmas of angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Furans; Humans; Isosorbide Dinitrate; Nitrates; Placebos; Propranolol | 1969 |
[Methods o clinical evaluation of therapeutic agents for the treatment of angina pectoris].
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Dipyridamole; Electrocardiography; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Piperazines; Placebos; Propranolol; Statistics as Topic; Vasodilator Agents | 1970 |
Stress tests and the evaluation of anti-anginal drugs.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Electrocardiography; Erythrityl Tetranitrate; Evaluation Studies as Topic; Exercise Test; Heart; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate | 1967 |
Propranolol combined with isosorbide dinitrate versus placebo in angina pectoris.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Drug Synergism; Electrocardiography; Exercise Test; Furans; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Physical Exertion; Placebos; Propranolol | 1969 |
Evaluation of propranolol and of isosorbide dinitrate in angina pectoris.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Furans; Humans; Isosorbide Dinitrate; Middle Aged; Nitrates; Placebos; Propranolol | 1969 |
Sublingual isosorbide dinitrate therapy versus sublingual acebo in angina pectoris.
Topics: Administration, Oral; Adult; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Furans; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Physical Exertion; Placebos | 1970 |
Evaluation of nitroglycerin in angina in patients on isosorbide dinitrate.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Furans; Heart; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Placebos | 1970 |
Therapy of angina pectoris with propranolol and long-acting nitrates.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Exercise Test; Female; Furans; Heart Rate; Humans; Ischemia; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Placebos; Propranolol; Valsalva Maneuver; Vasodilator Agents | 1969 |
Therapy of angina pectoris with propranolol and long-acting nitrates.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Exercise Test; Female; Furans; Heart Function Tests; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Placebos; Propranolol | 1969 |
The effects of chewable isosorbide dinitrate in coronary insufficiency. A report on exercise electrocardiograms in 13 patients.
Topics: Administration, Oral; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electrocardiography; Exercise Test; Female; Furans; Heart; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Placebos | 1971 |
Clinical and circulatory effects of isosorbide dinitrate. Comparison with nitroglycerin.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Drug Synergism; Electrocardiography; Furans; Heart; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Myocardium; Nitrates; Nitroglycerin; Oxygen Consumption; Physical Exertion; Placebos; Time Factors | 1971 |
Quantitative angiography: the measurement of coronary vasomobility in the intact animal and man.
Topics: Administration, Oral; Adult; Angina Pectoris; Angiocardiography; Animals; Cineangiography; Clinical Trials as Topic; Coronary Disease; Coronary Vessels; Dogs; Elasticity; Female; Furans; Humans; Isosorbide Dinitrate; Male; Methods; Middle Aged; Nitrates; Nitroglycerin; Placebos; Sorbitol; Vasodilator Agents | 1971 |
Isosorbide dinitrate in angina.
Topics: Administration, Oral; Angina Pectoris; Evaluation Studies as Topic; Furans; Humans; Isosorbide Dinitrate; Myocardium; Nitrates; Oxygen Consumption; Placebos; Propranolol | 1971 |
Isosorbide di-nitrate in angina pectoris. A double-blind-study of 50 cases.
Topics: Adult; Aged; Angina Pectoris; Electrocardiography; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Placebos | 1970 |
Propranolol and isosorbide dinitrate synergism in angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Drug Synergism; Electrocardiography; Exercise Test; Female; Furans; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Placebos; Propranolol | 1968 |
Double blind controlled clinical trial of a long acting coronary vasodilator isosorbide dinitrate (sorbitrate).
Topics: Adult; Aged; Angina Pectoris; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Placebos | 1968 |
Dilemmas of angina pectoris.
Topics: Angina Pectoris; Digitalis Glycosides; Exercise Test; Furans; Humans; Isosorbide Dinitrate; Nitrates; Placebos; Propranolol | 1969 |
[Nitrate tolerance: pro and con].
Topics: Angina Pectoris; Cardiac Output; Clinical Trials as Topic; Drug Administration Schedule; Drug Tolerance; Headache; Heart Rate; Humans; Hypertension; Isosorbide Dinitrate; Long-Term Care; Nitrates; Nitroglycerin | 1984 |
Coronary vasodilation by nitrates is not mediated by the prostaglandin system: an angiographic and hemodynamic study.
Topics: Aspirin; Coronary Angiography; Coronary Vessels; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Prostaglandins; Vasodilator Agents | 1983 |
Short and long-acting oral nitrates for stable angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; United States; United States Food and Drug Administration; Vasodilator Agents | 1994 |
[Hemodynamics effects of continuous infusion of molsidomine and nitrates and subsequent oral medication in therapy of acute myocardial infarct].
Topics: Administration, Oral; Aged; Aged, 80 and over; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Myocardial Infarction; Nitrates; Nitroglycerin; Vasodilator Agents | 1994 |
Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure.
Topics: Biotransformation; Double-Blind Method; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Molsidomine; Nitrates; Pulmonary Wedge Pressure | 1994 |
Comparison of the therapeutic efficacy of continuous and intermittent injection of isosorbide dinitrate: a randomized study on unstable angina.
Topics: Adult; Aged; Angina, Unstable; Blood Pressure; Coronary Angiography; Cross-Over Studies; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Prospective Studies; Treatment Outcome; Vasodilator Agents | 1995 |
Hemodynamic and humoral effects at rest and after head-up tilt tests during 24-hour infusion of a new nitrate ester, ITF 296, compared with ISDN and placebo in healthy volunteers: a double-blind, randomized, within-subject study.
Topics: Adult; Benzoxazines; Blood Pressure; Cross-Over Studies; Double-Blind Method; Electrocardiography; Epinephrine; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Neurotransmitter Agents; Nitrates; Norepinephrine; Oxazines; Posture; Renin; Vasodilator Agents | 1995 |
Long-term nitrate treatment increases cardiac events in patients with healed myocardial infarction. Secondary Prevention Group.
Topics: Aged; Death, Sudden, Cardiac; Double-Blind Method; Drug Tolerance; Female; Heart Failure; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitrates; Nitroglycerin; Odds Ratio; Recurrence; Time Factors; Vasodilator Agents | 1996 |
Effects of antianginal therapy with a calcium antagonist and nitrates on dobutamine-atropine stress echocardiography. Comparison with exercise electrocardiography.
Topics: Atropine; Calcium Channel Blockers; Cardiotonic Agents; Coronary Disease; Diltiazem; Dobutamine; Dose-Response Relationship, Drug; Echocardiography; Electrocardiography; Exercise Test; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Nitrates; Parasympatholytics; Prospective Studies; Vasodilator Agents | 1997 |
Is it possible to develop drugs that act more selectively on large arteries?
Topics: Adult; Arteries; Benzoxazines; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Design; Humans; Isosorbide Dinitrate; Male; Nitrates; Nitric Oxide Donors; Oxazines; Pulse; Vascular Resistance; Vasodilation; Vasodilator Agents | 1999 |
Echo-dipyridamole stress test evaluation of isosorbide-5-mononitrate efficacy and tolerance in patients with coronary heart disease: interplay with sympathetic activity.
Topics: Aged; Analysis of Variance; Blood Pressure; Coronary Disease; Cross-Over Studies; Dipyridamole; Double-Blind Method; Echocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Prospective Studies; Vasodilator Agents | 2000 |
[Nitrates in therapy of effort angina in hypotensive patients].
Topics: Angina Pectoris; Cross-Over Studies; Exercise Test; Humans; Hypotension; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nitrates; Nitric Oxide Donors; Nitroglycerin; Placebos; Time Factors; Vasodilator Agents | 2003 |
Pharmacokinetics of three organic nitrates in Chinese healthy male volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chromatography, Gas; Cross-Over Studies; Electrocardiography; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Nitrates; Vasodilator Agents | 2004 |
Nitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial.
Topics: Administration, Cutaneous; Administration, Sublingual; Age Factors; Biomarkers; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Chemistry, Pharmaceutical; Clinical Protocols; Female; Headache; Humans; Isosorbide Dinitrate; Middle Aged; Nitrates; Nitroglycerin; Ointments; Ontario; Postmenopause; Research Design; Tablets; Time Factors; Transdermal Patch; Treatment Outcome | 2013 |
The role of sustained release isosorbide mononitrate on corticosteroid-induced hypertension in healthy human subjects.
Topics: Adult; Anti-Inflammatory Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Healthy Volunteers; Humans; Hydrocortisone; Hypertension; Isosorbide Dinitrate; Male; Nitrates; Nitric Oxide Donors; Nitrites; Young Adult | 2015 |
165 other study(ies) available for isosorbide dinitrate and nitrates
| Article | Year |
|---|---|
[New nitrate indications].
Topics: Dihydralazine; Drug Combinations; Heart Diseases; Humans; Hydralazine; Isosorbide Dinitrate; Myocardial Infarction; Nitrates; Nitroglycerin; Nitroprusside; Phentolamine; Vasodilator Agents | 1978 |
[2. International Symposium on Nitrates; Berlin 1-3 June 1978. Nitrate-effect on the heart and circulation].
Topics: Angina Pectoris; Animals; Blood Circulation; Coronary Disease; Heart; Heart Failure; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nitrates; Nitroglycerin; Nitroprusside; Rats | 1978 |
[Peroral nitrate therapy in severe cardiac insufficiency following acute myocardial infarct].
Topics: Administration, Oral; Aged; Delayed-Action Preparations; Heart Failure; Humans; Isosorbide Dinitrate; Middle Aged; Myocardial Infarction; Nitrates; Nitroglycerin | 1978 |
[Response of the arteriolar circulation evaluated by means of photoplethysmography after nitroderivatives].
Topics: Arterial Occlusive Diseases; Arteries; Arterioles; Blood Circulation; Erythrityl Tetranitrate; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Plethysmography | 1977 |
Effect of 2-nicotinamidethyl nitrate (SG 75) on coronary circulation.
Topics: Animals; Constriction, Pathologic; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Ligation; Niacinamide; Nifedipine; Nitrates; Nitroglycerin; Papaverine; Vasodilator Agents; Verapamil | 1978 |
Drug management of stable angina pectoris.
Topics: Angina Pectoris; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Physical Exertion; Propranolol; Vasodilator Agents | 1977 |
Usefulness of long-acting nitrates in cardiovascular disease.
Topics: Cardiovascular Diseases; Coronary Disease; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Time Factors; Vasodilator Agents | 1978 |
Simultaneous determination of isosorbide dinitrate and its mononitrates in human plasma by capillary column GLC.
Topics: Biotransformation; Chromatography, Gas; Humans; Isosorbide; Isosorbide Dinitrate; Methods; Nitrates | 1979 |
Comparative vasodilator effects of nitroglycerin, pentaerythritol trinitrate and biometabolites, and other organic nitrates.
Topics: Animals; Coronary Vessels; Dogs; Drug Interactions; Female; Hemodynamics; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Propylene Glycols; Regional Blood Flow; Tachyphylaxis; Vasodilator Agents | 1975 |
The gastrointestinal absorption of organic nitrates.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Dogs; Humans; Intestinal Absorption; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Rabbits; Rats; Tablets | 1975 |
[Proceedings: The effect of nitrates on the systemic circulation and the myocardial oxygen consumption].
Topics: Blood Circulation; Coronary Disease; Coronary Vessels; Humans; Isosorbide Dinitrate; Myocardium; Nitrates; Nitroglycerin; Oxygen Consumption; Regional Blood Flow | 1975 |
Long-acting nitrates in the treatment of angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Erythrityl Tetranitrate; Hemodynamics; Humans; Isosorbide Dinitrate; Methods; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Physical Exertion; Substance-Related Disorders | 1976 |
[Influence of nitrates on regional myocardial blood flow and left ventricular wall motion].
Topics: Coronary Circulation; Coronary Disease; Diagnosis, Computer-Assisted; Heart Ventricles; Humans; Isosorbide Dinitrate; Myocardial Contraction; Nitrates; Nitroglycerin; Regional Blood Flow; Vascular Resistance; Xenon Radioisotopes | 1976 |
Oral nitrate therapy in coronary artery disease.
Topics: Administration, Oral; Angina Pectoris; Blood Pressure; Coronary Disease; Humans; Isosorbide Dinitrate; Myocardium; Nitrates; Oxygen Consumption | 1977 |
[Isotope study of the effects of a nitrate derivative on pulmonary blood volume. Application in the treatment of cardiogenic pulmonary edema].
Topics: Aged; Blood Pressure; Blood Volume; Capillary Resistance; Depression, Chemical; Heart Failure; Heart Ventricles; Humans; Isosorbide Dinitrate; Lung; Middle Aged; Nitrates; Pulmonary Circulation; Pulmonary Edema | 1976 |
[Nitrates and stomach carcinoma].
Topics: Food Preservation; Humans; Isosorbide Dinitrate; Japan; Nitrates; Stomach Neoplasms | 1976 |
[Effects of isosorbide dinitrate of prolonged action on the prevention of myocardial ischemia induced by exercise: correlation with nitrate blood levels].
Topics: Adult; Aged; Coronary Disease; Delayed-Action Preparations; Drug Evaluation; Female; Heart Function Tests; Humans; Ischemia; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Physical Exertion | 1975 |
Concentrations of the vasodilator isosorbide dinitrate and its metabolites in the blood of human subjects.
Topics: Biotransformation; Carbon Radioisotopes; Humans; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Nitrates | 1975 |
[Therapy of coronary disease].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dipyridamole; Drug Therapy, Combination; Humans; Isosorbide Dinitrate; Metoprolol; Nitrates; Smoking; Verapamil | 1992 |
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
Topics: Animals; Antioxidants; Aorta, Thoracic; Drug Tolerance; Female; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Nitrates; Nitroglycerin; Parasympatholytics; Rabbits; Vasodilator Agents | 1992 |
[Nitrate derivatives, current pharmacological and clinical status. Seville, 24-28 October 1991].
Topics: Animals; Cardiovascular System; Humans; Isosorbide Dinitrate; Nitrates | 1992 |
Pharmacokinetics of the organic nitrates trans-2-amino-2-methyl-N-(4- nitroxycyclohexylmethyl)-propionamide in dogs, and of 4-(2-nitroxyethyl)-piperidine in dogs and in monkeys.
Topics: Administration, Oral; Amides; Animals; Biological Availability; Chromatography, Gas; Dogs; Female; Half-Life; Injections, Intravenous; Isosorbide Dinitrate; Macaca; Male; Nitrates; Piperidines; Vasodilator Agents | 1992 |
Nitrates.
Topics: Cardiovascular Diseases; Coronary Disease; Drug Interactions; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Patient Education as Topic | 1992 |
Molecular mechanisms of nitrovasodilator bioactivation.
Topics: Amyl Nitrite; Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Methemoglobin; Molsidomine; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins | 1991 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 1990 |
Gas chromatographic analysis of isomeric organic mononitrates in plasma.
Topics: Animals; Chromatography, Gas; Isomerism; Isosorbide Dinitrate; Nitrates; Rats | 1991 |
Mechanisms of nitrate-induced vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cysteine; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Vasodilation | 1990 |
Cytochrome P-450 mediated biotransformation of organic nitrates.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chromatography, Gas; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Isosorbide Dinitrate; Kinetics; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitroglycerin; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Effectiveness of interval nitrate therapy in angina pectoris.
Topics: Administration, Cutaneous; Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1989 |
[Ambulatory treatment of chronic cardiac insufficiency with prolonged administration of nitrates].
Topics: Administration, Oral; Cardiac Glycosides; Coronary Disease; Diuretics; Drug Evaluation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Time Factors | 1989 |
Nitrate tolerance and its consequences for the clinician.
Topics: Angina Pectoris; Animals; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1989 |
Effect of pertussis toxin and the cGMP lowering agent LY83583 on the relaxation induced by nitrates in isolated bovine mesenteric artery. A comparison between glyceryl trinitrate, isosorbide dinitrate and isosorbide 5-mononitrate.
Topics: Aminoquinolines; Animals; Cattle; Cyclic GMP; Isosorbide Dinitrate; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Pertussis Toxin; Vascular Resistance; Virulence Factors, Bordetella | 1989 |
[Effect of beta-adrenergic blockaders and nitrates on left ventricular diastolic function in patients with ischemic heart disease].
Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Coronary Disease; Diastole; Drug Evaluation; Drug Therapy, Combination; Heart; Heart Ventricles; Humans; Isosorbide Dinitrate; Middle Aged; Myocardial Contraction; Nitrates; Propranolol; Time Factors | 1989 |
[Drugs in secondary prevention of ischemic heart disease: achievements, problems and prospects].
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Metoprolol; Nadolol; Nifedipine; Nitrates; Nitroglycerin; Propranolol; Verapamil | 1989 |
Effects of atrial natriuretic polypeptide and organic nitrates on levels of relaxation and cyclic nucleotide of canine coronary artery with and without endothelial injury.
Topics: Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Endothelium, Vascular; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilation | 1988 |
Mode of action of nitrates with regard to vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1986 |
Mechanism of vasodilation by nitrates: role of cyclic GMP.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilator Agents | 1987 |
Nitrates do not affect prostacyclin formation by rat arteries: this is unrelated to increased vascular prostacyclin formation with age.
Topics: 6-Ketoprostaglandin F1 alpha; Aging; Animals; Arteries; Epoprostenol; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Rats; Rats, Inbred Strains | 1987 |
Guanylate cyclase activation by organic nitrates is not mediated via nitrite.
Topics: Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Kinetics; Niacinamide; Nicorandil; Nitrates; Nitrites; Nitroglycerin; Sulfhydryl Compounds; Vasodilator Agents | 1988 |
Mechanisms of nitrate-induced vasodilatation and tolerance on a biochemical base.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Cattle; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Isosorbide Dinitrate; Methylene Blue; Nitrates; Nitroglycerin; Nitroprusside; Vasodilation | 1985 |
Anion inhibition of the proton pump in rat liver multivesicular bodies.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphatases; Animals; Anions; Biological Transport; Chlorides; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Kinetics; Liver; Male; Membrane Potentials; Nitrates; Protons; Rats; Rats, Inbred Strains | 1986 |
Clinical relevance of nitrate hemodynamic attenuation.
Topics: Administration, Topical; Angina Pectoris; Coronary Disease; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Receptors, Drug; Vasodilation | 1986 |
[Corrective effect of nitrates and calcium antagonists on hemodynamics and ventilation in chronic bronchitis patients with a syndrome of pulmonary hypertension].
Topics: Bronchitis; Calcium Channel Blockers; Drug Therapy, Combination; Hemodynamics; Humans; Hypertension, Pulmonary; Isosorbide Dinitrate; Nifedipine; Nitrates; Nitroglycerin; Pulmonary Heart Disease; Respiration; Vasodilator Agents; Verapamil | 1987 |
Historical aspects of nitrate therapy.
Topics: Cardiovascular Diseases; History, 19th Century; History, 20th Century; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentanols | 1987 |
Determination of nitrates in plasma.
Topics: Biotransformation; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1987 |
Stimulation of coronary vascular PGI2 by organic nitrates.
Topics: Animals; Cattle; Coronary Vessels; Epoprostenol; Humans; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Platelet Aggregation; Stereoisomerism; Structure-Activity Relationship; Sugar Alcohols; Thromboxane A2; Vasodilator Agents | 1988 |
Nitrates: the problem of tolerance.
Topics: Angina Pectoris; Drug Tolerance; Heart Failure; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1988 |
Coronary vasodilation by nitrates: any role for prostaglandins?
Topics: Aspirin; Coronary Circulation; Coronary Vessels; Drug Interactions; Humans; Isosorbide Dinitrate; Nitrates; Prostaglandins; Regional Blood Flow; Vasodilation | 1985 |
Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates.
Topics: Adult; Blood Platelets; Drug Synergism; Epoprostenol; Female; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Nitrates; Platelet Aggregation; Thromboxane B2 | 1988 |
Mononitrates as monotherapy in the prophylactic treatment of angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nitrates | 1987 |
The haemodynamic and anti-ischaemic effects of a single tablet of 80 mg isosorbide dinitrate in slow-release formulation and a review of nitrate tolerance.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Delayed-Action Preparations; Drug Tolerance; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates | 1987 |
[Bicycloalkanol nitrates].
Topics: Angina Pectoris; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Chemical Phenomena; Chemistry; Fatty Alcohols; Isosorbide Dinitrate; Nitrates; Rats | 1987 |
Nitrate therapy without loss of action by correct dosage.
Topics: Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Nitrates | 1986 |
Nitrates and endothelial prostacyclin production: studies in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Blood Vessels; Cells, Cultured; Endothelium; Epoprostenol; Humans; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Thromboxane B2; Vasodilator Agents | 1985 |
[Significance of nitrates in acute therapy of heart failure with and without lung edema].
Topics: Cardiac Output, Low; Cardiomyopathy, Dilated; Dobutamine; Drug Therapy, Combination; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pulmonary Edema; Regional Blood Flow; Shock, Cardiogenic | 1985 |
[Value of nitrates in modern coronary therapy].
Topics: Angina Pectoris; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Hemodynamics; Humans; Isosorbide Dinitrate; Long-Term Care; Nitrates | 1985 |
Nitrate tolerance.
Topics: Administration, Topical; Angina Pectoris; Blood Pressure; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Time Factors; Vasodilator Agents | 1985 |
[Nitrates and tolerance].
Topics: Animals; Cross Reactions; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Tachyphylaxis | 1985 |
[Nitrates in ischemic heart disease: the dependence of the effect on the route of administration and dosage of the preparation].
Topics: Administration, Oral; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Evaluation; Electrocardiography; Humans; Injections, Intravenous; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Ointments; Tablets; Time Factors | 1985 |
[Delayed release forms of nitrates--are they obsolete today?].
Topics: Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Resistance; Humans; Isosorbide Dinitrate; Nitrates | 1985 |
GLC determination of nitroglycerin and isosorbide dinitrate in human plasma.
Topics: Chromatography, Gas; Furans; Humans; Isosorbide Dinitrate; Methods; Nitrates; Nitroglycerin; Time Factors; Vasodilator Agents | 1973 |
Bioavailability studies of nitrates in the dog.
Topics: Administration, Oral; Animals; Biopharmaceutics; Blood Pressure; Cardiovascular System; Delayed-Action Preparations; Dogs; Dose-Response Relationship, Radiation; Heart; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Oxygen Consumption; Pentaerythritol Tetranitrate; Pulse; Vasodilator Agents | 1973 |
[Therapy of angina pectoris. II. Evaluation of antianginous drugs. Nitrites and nitrates].
Topics: Amyl Nitrite; Angina Pectoris; Drug Evaluation; Humans; Isosorbide Dinitrate; Mannitol; Nitrates; Nitrites; Nitroglycerin | 1974 |
Oral isosorbide and intraocular pressure.
Topics: Administration, Oral; Back Pain; Chromatography, Gas; Diarrhea; Diuretics; Furans; Glaucoma; Headache; Humans; Isosorbide Dinitrate; Nausea; Nitrates; Osmolar Concentration; Tonometry, Ocular; Vertigo | 1970 |
Effect of certain drugs on perfused human placenta. 8. Angiotensin-II antagonists.
Topics: Acetates; Angiotensin II; Atropine; Blood Pressure Determination; Cobalt; Cocaine; Cyproheptadine; Dibenzylchlorethamine; Dipyridamole; Ethanol; Female; Furans; Glycols; Humans; Hydralazine; In Vitro Techniques; Isosorbide Dinitrate; Muscles; Nitrates; Nitrites; Nitroglycerin; Papaverine; Perfusion; Phentolamine; Placenta; Pregnancy; Sodium; Sympatholytics; Tartrates; Tolazoline | 1968 |
Pharmacologic and biochemical evaluation of organic nitrates: attempted correlation of activities.
Topics: Animals; Chemistry, Organic; Dogs; Electron Transport; Erythrityl Tetranitrate; Evaluation Studies as Topic; Heart; In Vitro Techniques; Isosorbide Dinitrate; Mannitol; Mitochondria, Muscle; Myocardium; NAD; Nitrates; Nitroglycerin; Organic Chemistry Phenomena; Oxidative Phosphorylation; Oxidoreductases; Pentaerythritol Tetranitrate; Rats; Vasodilator Agents | 1971 |
Effect upon myocardial blood-flow in man of beta-blocking agents, isosorbide dinitrate, dipyridamole and their combination.
Topics: Adrenergic beta-Antagonists; Amino Alcohols; Blood Flow Velocity; Coronary Vessels; Dipyridamole; Drug Synergism; Furans; Humans; Isosorbide Dinitrate; Nitrates; Propranolol; Sympatholytics | 1970 |
Systemic and coronary vascular effects of the 2- and the 5-mononitrate esters of isosorbide.
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Electrocardiography; Furans; Heart Rate; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Perfusion; Pulse; Vascular Resistance | 1972 |
Organic nitrates: relationship between biotransformation and rational angina pectoris therapy.
Topics: Angina Pectoris; Animals; Biotransformation; Carbon Isotopes; Furans; Humans; Isosorbide Dinitrate; Liver; Mannitol; Nitrates; Nitroglycerin; Oxidoreductases; Rats; Vasodilator Agents | 1972 |
Clearance and metabolism of organic nitrates.
Topics: Adenosine Triphosphate; Animals; Blood; Carbon Isotopes; Erythrityl Tetranitrate; Glutathione; In Vitro Techniques; Isosorbide Dinitrate; Kinetics; Liver; Mannitol; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Rats | 1972 |
Medical treatment of angina pectoris. 3. Pharmacology of sublingual nitrites as antianginal drugs.
Topics: Angina Pectoris; Blood Flow Velocity; Blood Vessels; Dipyridamole; Furans; Heart; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardium; Nitrates; Nitrites; Nitroglycerin; Oxygen Consumption; Vasodilator Agents | 1972 |
Dissolution rate studies. II. Modified column apparatus and its use in evaluating isosorbide dinitrate tablets.
Topics: Chemistry; Furans; Isosorbide Dinitrate; Kinetics; Methods; Nitrates; Solubility; Spectrophotometry, Ultraviolet; Tablets; Vasodilator Agents | 1972 |
[The effect of isosorbide-dinitrate on pulmonary artery pressure in chronic pulmonary heart disease].
Topics: Administration, Oral; Aerosols; Aged; Blood Pressure; Brachial Artery; Catheterization; Chronic Disease; Delayed-Action Preparations; Furans; Humans; Hypotension; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Pulmonary Artery; Pulmonary Circulation; Pulmonary Heart Disease; Time Factors; Vasodilator Agents | 1972 |
Isosorbide dinitrate: its action on myocardial contractility in comparison with nitroglycerin.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Furans; Heart; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1973 |
Isosorbide, isomannide and isoidide dinitrate: urinary excretion in the rat.
Topics: Animals; Chromatography, Gas; Chromatography, Thin Layer; Ethers, Cyclic; Glucuronidase; Isosorbide Dinitrate; Male; Mannitol; Nitrates; Rats; Sugar Alcohols; Sulfatases; Time Factors | 1973 |
A correlation between the inhibition of monoamine oxidase activity and the relief of angina pain by organic nitrates.
Topics: Angina Pectoris; Animals; Carbon Isotopes; Erythrityl Tetranitrate; Furans; Humans; Isosorbide Dinitrate; Mannitol; Mitochondria, Muscle; Monoamine Oxidase Inhibitors; Myocardium; Nitrates; Nitroglycerin; Vasodilator Agents | 1968 |
Cardiopulmonary effects of glyceryl trinitrate and isosorbide dinitrate.
Topics: Animals; Blood; Coronary Vessels; Dogs; Furans; Heart; Heart Ventricles; Hemodynamics; Injections, Intravenous; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pulmonary Circulation; Regional Blood Flow; Vasodilator Agents | 1968 |
The use of isosorbide dinitrate in status anginosus.
Topics: Adult; Age Factors; Aged; Angina Pectoris; Electrocardiography; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin | 1970 |
[Conservative therapy of angina pectoris].
Topics: Acute Disease; Amyl Nitrite; Angina Pectoris; Anticoagulants; Coronary Disease; Digitalis Glycosides; Furans; Heart Failure; Humans; Hypotension, Orthostatic; Isosorbide Dinitrate; Morphine; Myocardial Infarction; Nitrates; Nitrites; Nitroglycerin; Pentaerythritol Tetranitrate; Propranolol; Rest; Sympatholytics; Syncope; Vascular Headaches | 1970 |
Angina prophylaxis by chewable isosorbide dinitrate.
Topics: Angina Pectoris; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Tablets | 1971 |
A ten-year reevaluation. Nitroglycerin and isosorbide dinitrate in coronary insufficiency.
Topics: Aged; Angina Pectoris; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin | 1971 |
Effect of nitrate infusions on the systemic and coronary circulations following acute experimental myocardial infarction in the intact dog.
Topics: Animals; Blood Circulation; Blood Pressure Determination; Cardiac Catheterization; Cardiac Output; Coronary Circulation; Dogs; Furans; Isosorbide Dinitrate; Methods; Myocardial Infarction; Nitrates; Shock, Cardiogenic; Vasodilator Agents | 1972 |
Identification of the urinary metabolites of isosorbide dinitrate in dogs.
Topics: Animals; Carbon Isotopes; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Dogs; Furans; Glucuronates; Glucuronidase; Isosorbide Dinitrate; Male; Nitrates | 1971 |
Evaluation of left ventricular function during routine cardiac catheterization: usefulness of DP-DT measurements in clinical cases.
Topics: Adult; Aged; Cardiac Catheterization; Coronary Disease; Female; Furans; Heart; Heart Aneurysm; Heart Function Tests; Heart Valve Diseases; Heart Ventricles; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates | 1971 |
[Controlled clinical test of the antianginal action of the association of isosorbide dinitrate and prenylamine theophyllineacetate].
Topics: Acetates; Adult; Aged; Angina Pectoris; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Prenylamine; Theophylline | 1970 |
[Significance of the nitrate test in unclear exertion ECG].
Topics: Adult; Electrocardiography; Exercise Test; Female; Furans; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates | 1970 |
[Exertion ECG in bundle branch block and WPW-syndrome with respect to the nitrate test].
Topics: Adult; Blood Pressure; Bundle-Branch Block; Electrocardiography; Exercise Test; Furans; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Wolff-Parkinson-White Syndrome | 1970 |
Rapid clearance of isosorbide dinitrate from rabbit blood--determination by gas chromatography.
Topics: Acetates; Animals; Chromatography, Gas; Furans; Isosorbide Dinitrate; Nitrates; Rabbits; Spectrum Analysis; Time Factors | 1970 |
Effect of propranolol on hemodynamic responses to isosorbide dinitrate in anesthetized dogs.
Topics: Animals; Blood Pressure; Dogs; Drug Synergism; Femoral Artery; Furans; Heart Rate; Isosorbide Dinitrate; Nitrates; Propranolol | 1971 |
Plasma concentrations and urinary excretion of isosorbide dinitrate and its metabolites in the dog.
Topics: Animals; Autoradiography; Biotransformation; Carbon Isotopes; Chromatography, Thin Layer; Dogs; Female; Furans; Glucuronates; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1971 |
[Effect of isosorbide dinitrate on the capillaries of the myocardium].
Topics: Animals; Capillaries; Female; Heart; Isosorbide Dinitrate; Male; Nitrates; Nitrites; Rats | 1967 |
Dilemmas of angina pectoris.
Topics: Angina Pectoris; Animals; Furans; Humans; Isosorbide Dinitrate; Nitrates; Propranolol | 1969 |
Dilemmas of angina pectoris.
Topics: Angina Pectoris; Furans; Isosorbide Dinitrate; Nitrates; Propranolol | 1969 |
The biotransformation of isosorbide dinitrate in dogs and humans.
Topics: Animals; Biotransformation; Chromatography; Dogs; Female; Furans; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1967 |
Nitrate therapy in a patient with papillary dysfunction.
Topics: Ampulla of Vater; Common Bile Duct Diseases; Female; Humans; Isosorbide Dinitrate; Middle Aged; Nitrates; Nitroglycerin; Sphincter of Oddi | 1983 |
Calcium antagonists, nitrates, and new antianginal drugs.
Topics: Angina Pectoris; Calcium Channel Blockers; Humans; Hypertension; Isosorbide Dinitrate; Lidoflazine; Nifedipine; Nitrates; Nitroglycerin; Perhexiline; Prenylamine; Tachycardia; Verapamil | 1983 |
Pharmacokinetics of nitroglycerin and long-acting nitrate esters.
Topics: Absorption; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Kinetics; Nitrates; Nitroglycerin | 1983 |
Blood vessel uptake and metabolism of organic nitrates in the rat.
Topics: Animals; Aorta; Blood Vessels; Carbon Radioisotopes; Femoral Vein; Isosorbide Dinitrate; Kinetics; Male; Nitrates; Nitroglycerin; Rats; Rats, Inbred Strains; Time Factors; Vena Cava, Inferior | 1984 |
Nitrates IV. Cardiovascular effects.
Topics: Heart Diseases; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1983 |
Methemoglobin levels produced by organic nitrates in patients with coronary artery disease.
Topics: Aged; Angina Pectoris; Angina, Unstable; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Methemoglobin; Middle Aged; Nitrates; Nitroglycerin | 1984 |
Nitrates for angina pectoris. A critical review of therapeutic efficacy and tolerance.
Topics: Angina Pectoris; Drug Tolerance; Electrocardiography; Hemodynamics; Humans; Isosorbide Dinitrate; Long-Term Care; Nitrates; Nitroglycerin; Physical Exertion | 1984 |
Investigations into the development of tolerance to organic nitrates in conscious dogs.
Topics: Animals; Blood Pressure; Dogs; Drug Tolerance; Female; Hemodynamics; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Time Factors | 1984 |
Nitrates in heart failure. Pathophysiological mechanisms and therapeutic applications.
Topics: Cardiac Output; Drug Therapy, Combination; Heart Failure; Hemodynamics; Humans; Hydralazine; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Myocardium; Nitrates; Nitroglycerin; Oxygen Consumption; Pulmonary Wedge Pressure; Vasodilation | 1984 |
Treatment of coronary heart disease with isosorbide mononitrate ('Elantan' 20): a multi-centre study in hospital and general practice.
Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin | 1984 |
[Tolerance for the antianginal effect of nitrates. Approaches to its study].
Topics: Angina Pectoris; Chronic Disease; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Exercise Test; Humans; Isosorbide Dinitrate; Male; Nitrates; Physical Exertion; Time Factors | 1984 |
The effect of nitrate on the oxygen availability during exercise in effort angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Biological Availability; Blood Pressure; Electrocardiography; Energy Metabolism; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Muscles; Nitrates; Oxygen; Physical Exertion; Respiration | 1984 |
[Tolerance or hemodynamic adaptation during nitrate therapy].
Topics: Adaptation, Physiological; Angina Pectoris; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1984 |
[Drug therapy of coronary disease. Nitrates in acute and longtime therapy].
Topics: Coronary Disease; Headache; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Time Factors | 1980 |
[Long-term treatment of coronary disease with nitrates. The prescribed dosage is mostly too low].
Topics: Coronary Disease; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1980 |
Hemodynamic effects of nitrates in chronic heart failure and myocardial infarction.
Topics: Chronic Disease; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardial Infarction; Nitrates; Nitroglycerin; Oxygen Consumption; Vasodilator Agents | 1980 |
[Are nitrate compounds effective when administered orally? Results of pharmacokinetic and hemodynamic studies].
Topics: Administration, Oral; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilator Agents | 1980 |
Nitrate tolerance and dependence. A critical assessment.
Topics: Angina Pectoris; Animals; Dogs; Drug Tolerance; Heart Failure; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Rabbits; Rats; Substance-Related Disorders; Tachyphylaxis; Vasodilator Agents | 1980 |
Verapamil therapy in variant angina pectoris refractory to nitrates.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Electrocardiography; Ergonovine; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Verapamil | 1981 |
Nitrates, package inserts, and the Food and Drug Administration. A clinical paradox.
Topics: Angina Pectoris; Biological Availability; Delayed-Action Preparations; Drug Labeling; Heart Failure; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; United States; United States Food and Drug Administration; Vasodilator Agents | 1981 |
Managing angina with nitrates.
Topics: Administration, Oral; Administration, Topical; Angina Pectoris; Angina Pectoris, Variant; Capsules; Delayed-Action Preparations; Humans; Injections, Intravenous; Isosorbide Dinitrate; Mouth Floor; Nitrates; Nitroglycerin; Ointments; Tablets | 1982 |
[Changes in the mechanical and electrophysiological properties of isolated blood vessels as a result of isosorbide-5-mononitrate. A comparison with the effect of other organic nitrates].
Topics: Animals; Aorta, Thoracic; Isosorbide Dinitrate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitrates; Portal Vein; Rats | 1981 |
Synthesis and pharmacology of a series of new organic nitrate esters.
Topics: Animals; Esters; Hemodynamics; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents | 1995 |
Nitrovasodilators ITF 296 and isosorbide dinitrate exert antiischemic activity by dilating coronary penetrating arteries.
Topics: Analysis of Variance; Animals; Benzoxazines; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs; Exercise Test; Heart Rate; Injections, Intravenous; Isosorbide Dinitrate; Laser-Doppler Flowmetry; Myocardial Ischemia; Myocardium; Nitrates; Oxazines; Vasodilation | 1995 |
The rationale for nitrates in angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Patient Compliance; Vasodilator Agents | 1995 |
Nitrate tolerance.
Topics: Administration, Cutaneous; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1995 |
A clinical and in vitro study on the possible interaction of intravenous nitrates with heparin anticoagulation.
Topics: Angina, Unstable; Drug Interactions; Drug Therapy, Combination; Female; Heparin; Humans; In Vitro Techniques; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Partial Thromboplastin Time; Prospective Studies | 1994 |
Influence of endothelium and nitrovasodilators on free thiols and disulfides in porcine coronary smooth muscle.
Topics: Analysis of Variance; Animals; Coronary Vessels; Cysteine; Disulfides; Drug Tolerance; Endothelium, Vascular; Histocytochemistry; In Vitro Techniques; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Sulfhydryl Compounds; Swine; Vasodilator Agents | 1993 |
[The efficacy of nitrate solutions in emergency states].
Topics: Angina Pectoris; Drug Evaluation; Emergencies; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Solutions | 1993 |
Pharmacokinetics of stereomeric 1,4:3,6-dianhydrohexitol mononitrates in rats.
Topics: Animals; Injections, Intravenous; Isosorbide Dinitrate; Male; Nitrates; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sugar Alcohols; Vasodilator Agents | 1993 |
Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms.
Topics: Biotransformation; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide; Nitroglycerin; Platelet Aggregation; Time Factors | 1995 |
Effect of nitrovasodilators on the rhythmic contractions of guinea-pig isolated sphincter of Oddi.
Topics: Acetylcholine; Animals; Female; Guinea Pigs; In Vitro Techniques; Isosorbide Dinitrate; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth; Nitrates; Nitroprusside; Pentanols; Sphincter of Oddi; Vasodilator Agents | 1995 |
Specificity of different organic nitrates to elicit NO formation in rabbit vascular tissues and organs in vivo.
Topics: Animals; Aorta; Blood Vessels; Cysteine; Cytochrome P-450 Enzyme System; Dipeptides; Electron Spin Resonance Spectroscopy; Guanylate Cyclase; In Vitro Techniques; Isometric Contraction; Isosorbide Dinitrate; Kidney; Liver; Muscle Relaxation; Nitrates; Nitric Oxide; Nitroglycerin; Rabbits; Sensitivity and Specificity; Solubility; Sulfhydryl Compounds; Vasodilator Agents; Venae Cavae | 1995 |
Evaluation of nitric oxide formation from nitrates in pig coronary arteries.
Topics: Animals; Coronary Vessels; Cysteine; Glutathione Transferase; In Vitro Techniques; Isosorbide Dinitrate; Liver; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Swine; Vasodilation | 1996 |
ITF 296, a new endothelium-independent vasodilator: comparison with nitroglycerin and isosorbide dinitrate.
Topics: Animals; Benzoxazines; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Hemodynamics; Isosorbide Dinitrate; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Oxazines; Vasodilator Agents | 1995 |
The new nitroderivative ITF 296 improves collateral blood flow in a canine model of coronary thrombosis.
Topics: Anesthesia; Animals; Benzoxazines; Collateral Circulation; Coronary Circulation; Coronary Thrombosis; Dogs; Female; Isosorbide Dinitrate; Male; Microspheres; Nitrates; Oxazines; Vasodilator Agents | 1995 |
Mechanism of ITF 296-induced vasorelaxation compared to nitroglycerin and isosorbide dinitrate: relationship between relaxation of rabbit aorta and tissue cGMP.
Topics: Animals; Aorta, Thoracic; Benzoxazines; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Oxazines; Rabbits; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Calcium-activated potassium channels and nitrate-induced vasodilation in human coronary arteries.
Topics: Coronary Vessels; Heart; Humans; Hydrazines; Isosorbide Dinitrate; Mutagens; Myocardial Contraction; Nitrates; Nitrogen Oxides; Nitroprusside; Potassium Channels; Vasodilation; Vasodilator Agents | 1998 |
Impaired modulation of sympathetic excitability by nitric oxide after long-term administration of organic nitrates in pigs.
Topics: Animals; Brain Stem; Consciousness; Drug Tolerance; Enzyme Inhibitors; Hemodynamics; Injections, Intraventricular; Isosorbide Dinitrate; NADPH Dehydrogenase; Nerve Tissue Proteins; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Penicillamine; Swine; Sympathetic Nervous System; Vasodilator Agents | 1998 |
Nitrate-stimulated tilt test.
Topics: Heart Rate; Humans; Isosorbide Dinitrate; Nitrates; Syncope, Vasovagal; Tilt-Table Test; Time Factors; Vasodilator Agents | 1999 |
Effects of the flavoprotein inhibitor, diphenyleneiodonium sulfate, on ex vivo organic nitrate tolerance in the rat.
Topics: Animals; Aorta, Thoracic; Biotransformation; Blotting, Northern; Drug Tolerance; Enzyme Inhibitors; Flavoproteins; Glutathione; Isosorbide Dinitrate; Male; Microsomes; Muscle, Smooth, Vascular; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Nitroso Compounds; Onium Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; S-Nitrosoglutathione; Stereoisomerism; Superoxides; Vasodilator Agents | 2000 |
[Role of nitrates in the treatment of ischemia].
Topics: Angina Pectoris; Coronary Disease; Emergencies; Humans; Hypotension, Orthostatic; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Time Factors; Vasodilator Agents | 2000 |
Packed-column supercritical fluid chromatography for the analysis of isosorbide-5-mononitrate and related compounds in bulk substance and tablets.
Topics: Chromatography; Chromatography, Liquid; Ions; Isosorbide Dinitrate; Nitrates; Sulfates; Tablets; Temperature; Time Factors | 2000 |
Successful management of intractable coronary spasm with a coronary stent.
Topics: Adult; Amlodipine; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm; Diltiazem; Doxazosin; Drug Resistance; Drug Therapy, Combination; Ergonovine; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nicorandil; Nitrates; Pyridines; Stents; Ticlopidine; Ventricular Fibrillation | 2000 |
Stereoselective pharmacokinetics and pharmacodynamics of organic nitrates in rats.
Topics: Animals; Blood Pressure; Isosorbide Dinitrate; Male; Models, Biological; Nitrates; Rats; Rats, Wistar; Stereoisomerism; Sugar Alcohols; Vasodilator Agents | 2001 |
Escape from tolerance of organic nitrate by induction of cytochrome P450.
Topics: Animals; Blood Pressure; Blotting, Western; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Tolerance; Enzyme Induction; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydrazines; Immunohistochemistry; Interleukin-1; Isoenzymes; Isosorbide Dinitrate; Kinetics; Male; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Rats; Rats, Wistar | 2001 |
The prescription pattern of oral nitrates in coronary artery disease. Appropriateness and cost considerations.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Coronary Artery Disease; Costs and Cost Analysis; Delayed-Action Preparations; Drug Prescriptions; Drug Utilization; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Practice Patterns, Physicians'; Vasodilator Agents | 2001 |
[Do nitrates reduce the risk of drug induced hemorrhage of the upper gastrointestinal tract?].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Nitrates; Risk Factors | 2001 |
Penile erectile responses to cavernous nerve stimulation in rats are not affected by nitrate tolerance.
Topics: Animals; Blood Pressure; Drug Tolerance; Electric Stimulation; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Penile Erection; Rats | 2002 |
Significance of asymmetric dimethylarginine (ADMA) concentrations during coronary circulation in patients with vasospastic angina.
Topics: Aged; Angina Pectoris; Arginine; Case-Control Studies; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Enzyme Inhibitors; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitrites; Osmolar Concentration; Risk Factors; Vasodilator Agents; Vasomotor System | 2003 |
Organic nitrate tolerance is induced by degradation of some cytochrome P450 isoforms.
Topics: Animals; Blotting, Western; Cytochrome P-450 CYP1A2; Humans; Immunohistochemistry; Isosorbide Dinitrate; Male; Nitrates; Nitric Oxide; Nitroglycerin; Protein Isoforms; Rats; Rats, Wistar; Time Factors; Vasodilator Agents | 2002 |
Clinical trial of sorbide nitrate, a long-acting coronary artery dilator.
Topics: Angina Pectoris; Coronary Vessels; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1963 |
Clinical evaluation of sublingual nitrates. Onset and duration of action of nitroglycerin and isosorbide dinitrate.
Topics: Angina Pectoris; Humans; Isosorbide Dinitrate; Nitrates; Nitrites; Nitroglycerin; Vasodilator Agents | 1963 |
ISOSORBIDE DI-NITRATE ("SORBITRATE')--A NEW ANTI-ANGINAL DRUG.
Topics: Angina Pectoris; Biomedical Research; Chemical Phenomena; Chemistry; Drug Therapy; Drug Tolerance; Humans; Isosorbide; Isosorbide Dinitrate; Nitrates; Nitrites; Placebos; Sorbitol; Toxicology | 1964 |
Continuous administration of organic nitrate decreases hepatic cytochrome P450.
Topics: Animals; Blotting, Western; Catalase; Cytochrome P-450 Enzyme System; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Isosorbide Dinitrate; Liver; Male; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Rats; Rats, Wistar | 2004 |
[Continuous protection against angina pectoris-like disorders. Attack prevention without a nitrate pause].
Topics: Angina Pectoris; Coronary Disease; Free Radicals; Humans; Isosorbide Dinitrate; Myocardial Infarction; Nitrates; Nitric Oxide Donors; Oxidative Stress; Pentaerythritol Tetranitrate; Time Factors; Vasodilator Agents | 2003 |
Tolerance induction during therapy with long-acting nitrates: how extensive is the "collateral damage"?
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Humans; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Nitric Oxide Donors; Nitroglycerin | 2004 |
Impairment of gastrointestinal motility by nitrate administration: evaluation based on electrogastrographic changes and autonomic nerve activity.
Topics: Aged; Autonomic Nervous System; Chest Pain; Electrocardiography, Ambulatory; Electrophysiology; Gastrointestinal Motility; Heart Rate; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide Donors; Postprandial Period; Spectrum Analysis | 2004 |
Long-term therapy with organic nitrates: the pros and cons of nitric oxide replacement therapy.
Topics: Animals; Antioxidants; Clinical Trials as Topic; Drug Tolerance; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide Donors; Oxidation-Reduction; Prodrugs; Time Factors | 2004 |
Continuous treatment with organic nitrate affects hepatic cytochrome P450.
Topics: Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Drug Tolerance; Isosorbide Dinitrate; Liver; Male; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitrites; Nitroglycerin; Protein Isoforms; Rats; Rats, Wistar | 2004 |
Development of a novel nitrate-selective composite sensor based on doped polypyrrole.
Topics: Calibration; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Nitrates; Polymers; Pyrroles; Sensitivity and Specificity | 2007 |
Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates.
Topics: Animals; Aspirin; Coronary Vessels; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Immunohistochemistry; In Vitro Techniques; Isoenzymes; Isosorbide Dinitrate; Male; Microsomes; Myocardium; Nitrates; Nitric Oxide; Rats; Saccharomyces cerevisiae | 2007 |
Do we still need organic nitrates?
Topics: Cardiovascular Diseases; Endothelium, Vascular; Free Radicals; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide Donors; Vasodilator Agents | 2007 |
Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter.
Topics: Anal Canal; Animals; Isosorbide Dinitrate; Models, Animal; Muscle Relaxation; Muscle, Smooth; Nitrates; Nitric Oxide Donors; Nitroprusside; Rabbits | 2008 |
Use of organic nitrates and the risk of hip fracture: a population-based case-control study.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Epidemiologic Methods; Female; Hip Fractures; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Odds Ratio; Population; Risk; Vasodilator Agents; Young Adult | 2010 |
Nitric oxide donors improve prednisone effects on muscular dystrophy in the mdx mouse diaphragm.
Topics: Animals; Body Weight; Calcinosis; Diaphragm; Female; Guaifenesin; Isosorbide Dinitrate; Male; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Diseases; Muscular Dystrophy, Duchenne; Nitrates; Nitric Oxide Donors; Organ Size; Prednisone; Regeneration | 2011 |
A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology.
Topics: Acrylic Resins; Animals; Carbonic Anhydrases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glaucoma; Isosorbide Dinitrate; Male; Molecular Structure; Nitrates; Nitric Oxide; Rabbits; Sulfonamides; Thiophenes; Time Factors | 2012 |
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Blood Platelets; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Humans; Hypotension; Isosorbide Dinitrate; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Thrombin; Tyrosine; Vasodilator Agents | 2014 |
Repeated Dosing with NCX1404, a Nitric Oxide-Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Hyperalgesia; Isosorbide Dinitrate; Male; Mice; Neuralgia; Nitrates; Nitric Oxide Donors; Nociception; Pain Measurement; Pregabalin | 2016 |
Vericiguat, organic nitrates, and heart failure in African Americans.
Topics: Black or African American; Heart Failure; Heterocyclic Compounds, 2-Ring; Humans; Hydralazine; Isosorbide Dinitrate; Nitrates; Pyrimidines; Stroke Volume | 2021 |
Endocrine disruption: Reproductive toxicity of glyceryl trinitrate and isosorbide mononitrate in male Wistar rats.
Topics: Animals; Isosorbide Dinitrate; Luteinizing Hormone; Male; Nitrates; Nitric Oxide; Nitroglycerin; Oxidative Stress; Rats; Rats, Wistar; Semen; Sperm Count; Sperm Motility; Spermatozoa; Testis; Testosterone | 2022 |