isosorbide dinitrate has been researched along with nicorandil in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (22.41) | 18.7374 |
| 1990's | 15 (25.86) | 18.2507 |
| 2000's | 17 (29.31) | 29.6817 |
| 2010's | 12 (20.69) | 24.3611 |
| 2020's | 1 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| MacLeod, D; Suryapranata, H | 1 |
| Döring, G | 1 |
| Wagner, G | 1 |
| Henry, PJ; Horowitz, JD; Louis, WJ | 1 |
| Cadeddu, M; Cherchi, A; Lai, C; Lai, G; Onnis, E; Orani, E; Solinas, R | 1 |
| Karaki, H; Murakami, K; Urakawa, N | 1 |
| Kuromaru, O; Sakai, K | 2 |
| Holzmann, S; Kukovetz, WR | 1 |
| Kukovetz, WR; Romanin, C | 1 |
| Hader, S; Leitold, M | 1 |
| Araki, H; Hayata, N; Matsuguchi, T; Nakamura, M | 1 |
| Gross, GJ; Pieper, GM | 1 |
| Ohba, Y; Sakai, K; Shiraki, Y | 1 |
| Hellige, G; Hoeft, A; Hunneman, DH; Korb, H; Schraeder, R; Wolpers, HG | 1 |
| Akima, M; Hinohara, Y; Obatake, N; Sakai, K | 1 |
| Hirakawa, S; Ito, H | 1 |
| Belz, GG; Heinrich, J; Matthews, J; Wagner, G | 1 |
| Hoeks, AP; Kool, MJ; Reneman, RS; Spek, JJ; Struyker Boudier, HA; Van Bortel, LM; van Herwaarden, RH | 1 |
| Bueno, O; Zavecz, JH | 1 |
| Aniya, Y; Naito, A; Sakanashi, M | 1 |
| Adachi, H; Kodama, K; Mori, N; Saito, I | 1 |
| Kato, K | 1 |
| Drummer, C; Gerzer, R; Ivanova, K; Schaefer, M | 1 |
| Branzi, A; Galiè, N; Guarnieri, C; Magnani, B; Parlangeli, R; Traini, AM; Ussia, GP; Vaona, I; Zimarino, M | 1 |
| Ejima, J; Fujino, T; Kaji, Y; Kanaya, S; Kaneda, K; Maruyama, T; Moriyama, H; Niho, Y; Ohmura, I; Tsuda, Y | 1 |
| Bona, M; Marsico, F; Micheletti, T; Specchia, G | 1 |
| Aya, G; de La Coussaye, JE; Delye, B; Eledjam, JJ; Juan, JM; Péray, P; Robert, E; Sassine, A | 1 |
| Arai, M; Fujiwara, H; Hayakawa, K; Kawasaki, M; Matsubara, T; Matsuno, Y; Matsuo, H; Minatoguchi, S; Nishigaki, K; Noda, T; Segawa, T; Takemura, G; Uno, Y; Watanabe, S | 1 |
| Ahn, YK; Bae, Y; Cho, JG; Cho, JH; Jeong, MH; Kang, JC; Kang, KT; Kim, KH; Kim, NH; Kim, SH; Lee, SH; Park, JC; Rhew, JY | 1 |
| Hirai, M; Iino, S; Kondo, T; Takeshita, K; Tanaka, T | 1 |
| Fujii, M; Hashimoto, S; Ikeda, N; Kawakami, M; Kubo, N; Saito, M; Tsuruya, Y; Yasu, T | 1 |
| Fukumoto, Y; Inokuchi, K; Ito, A; Masuda, M; Matoba, T; Morita, S; Nishida, T; Shimokawa, H; Shiose, A | 1 |
| Ahn, YK; Cho, JG; Hong, SN; Hong, YJ; Jeong, MH; Kang, DK; Kang, JC; Kim, JH; Kim, KH; Kim, W; Lee, SH; Lee, YS; Lim, SY; Park, HW; Park, JC; Yun, KH | 1 |
| Fujii, S; Kitabatake, A; Oyama, N; Sakai, H; Urasawa, K | 1 |
| Ichikawa, S; Kasama, S; Kumakura, H; Kurabayashi, M; Suzuki, T; Takayama, Y; Toyama, T | 1 |
| Akutsu, H; Funada, J; Ohtani, T; Sato, M; Sekiya, M; Watanabe, K | 1 |
| Hatori, T; Ichikawa, S; Kasama, S; Kumakura, H; Kurabayashi, M; Suzuki, T; Takayama, Y; Toyama, T | 1 |
| Ahn, YK; Cho, JG; Jeong, MH; Kang, JC; Kim, W; Park, JC | 1 |
| Horinaka, S; Kobayashi, N; Matsuoka, H; Mori, Y; Yagi, H | 1 |
| Cockcroft, JR; Mason, RP | 1 |
| Chen, JZ; Guo, JX; He, Q; Jia, SQ; Li, TD; Li, ZQ; Shan, YD; Wei, JP; Wu, ZG; Yang, XC; You, K; Zhu, WL | 1 |
| Hayashi, T; Ichikawa, M; Iwata, A; Lim, YJ; Mishima, M; Nakata, T | 1 |
| Eguchi, Y; Higashijima, N; Ishida, H; Ishizuka, N; Kawamura, Y; Takahari, Y; Tamura, N | 1 |
| Iwamoto, K; Morishige, K; Sadamatsu, K; Shikada, T; Tanaka, H; Tashiro, H; Tokunou, T; Yoshida, K; Yoshidomi, Y | 1 |
| Furuya, A; Sakurai, T; Sugibayashi, K; Takeuchi, H; Terasaka, S; Urano, H | 1 |
| Furuya, A; Mano, Y; Sakurai, T; Sugibayashi, K; Takeuchi, H; Terasaka, S; Urano, H | 1 |
| Furuya, A; Ishida, M; Sugibayashi, K; Takeuchi, H; Todo, H; Urano, H | 1 |
| Daida, H; Hiki, M; Nakazato, Y; Tokano, T | 1 |
| Ikari, Y; Kiyooka, T; Kobayashi, Y | 1 |
| Asano, M; Goto, K; Hirao, K; Isobe, M; Kurabayashi, M; Nakamura, T; Okishige, K; Sasano, T; Shimura, T; Suzuki, H | 1 |
| Dixit, D; Kimborowicz, K | 1 |
| Kozlova, NV; Shameeva, ES; Sizova, ZM; Zakharova, VL | 1 |
| Ishii, H; Isobe, S; Iwata, H; Murohara, T; Sawada, K; Yamada, K; Yokouchi, K | 1 |
| Huang, Y; Singh, B; Wu, T; Xu, J; Yu, X; Zhao, N | 1 |
| Al-Lamee, R; Davies, JR; Foley, M; Francis, DP; Ganesananthan, S; Gerber, R; Howard, J; Keeble, TR; Malik, IS; Nijjer, S; Nowbar, AN; O'Kane, P; Petraco, R; Rajkumar, CA; Seligman, H; Sen, S; Sharp, ASP; Shun-Shin, M; Tang, KH | 1 |
5 review(s) available for isosorbide dinitrate and nicorandil
| Article | Year |
|---|---|
Pharmacologic therapy of angina pectoris.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Drug Therapy, Combination; Enoximone; Heparin; Humans; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Piperazines; Ranolazine; Vasodilator Agents | 1995 |
Haemodynamic and clinical effects of an intravenous potassium channel opener--a review.
Topics: Administration, Sublingual; Angina, Unstable; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1993 |
Targeting nitric oxide with drug therapy.
Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzopyrans; Biological Availability; Calcium Channel Blockers; Carbazoles; Carvedilol; Ethanolamines; Heart Diseases; Humans; Isosorbide Dinitrate; Nebivolol; Neurodegenerative Diseases; Nicorandil; Nitrates; Nitric Oxide; Nitric Oxide Donors; Propanolamines; Vasodilator Agents | 2006 |
Pharmacologic management of chronic stable angina.
Topics: Adrenergic beta-Antagonists; Angina, Stable; Benzazepines; Calcium Channel Blockers; Cardiovascular Agents; Humans; Isosorbide Dinitrate; Ivabradine; Nicorandil; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Vasodilator Agents | 2015 |
Nitrates for the prevention of cardiac morbidity and mortality in patients undergoing non-cardiac surgery.
Topics: Cause of Death; Heart Diseases; Humans; Isosorbide Dinitrate; Morbidity; Nicorandil; Nitroglycerin; Postoperative Complications; Randomized Controlled Trials as Topic; Surgical Procedures, Operative; Vasodilator Agents | 2016 |
16 trial(s) available for isosorbide dinitrate and nicorandil
| Article | Year |
|---|---|
Antianginal and anti-ischemic efficacy of nicorandil in comparison with isosorbide-5-mononitrate and isosorbide dinitrate: results from two multicenter, double-blind, randomized studies with stable coronary heart disease patients.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Exercise; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1992 |
Selected issues from an overview on nicorandil: tolerance, duration of action, and long-term efficacy.
Topics: Administration, Oral; Administration, Sublingual; Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Exercise; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin | 1992 |
[A new anti-ischemic drug for the treatment of stable effort angina pectoris: nicorandil. Comparison with placebo and isosorbide-5-mononitrate].
Topics: Aged; Angina Pectoris; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Placebos; Vasodilator Agents | 1991 |
Controlled comparison of the pharmacodynamic effects of nicorandil (SG-75) and isosorbide dinitrate in man.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Systole; Vasodilator Agents | 1984 |
Acute and subacute effects of nicorandil and isosorbide dinitrate on vessel wall properties of large arteries and hemodynamics in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Biomarkers; Blood Pressure; Brachial Artery; Carotid Arteries; Compliance; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Echocardiography, Doppler; Femoral Artery; Heart Rate; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Regression Analysis; Stroke Volume; Vascular Resistance; Vasodilator Agents | 1995 |
Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.
Topics: Angina Pectoris; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Niacinamide; Nicorandil; Sick Sinus Syndrome; Vasodilator Agents | 1995 |
[Clinical use of potassium channel activators in angina pectoris: efficacy and tolerance].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Coronary Angiography; Electrocardiography; Female; Hemodynamics; Humans; Injections, Intravenous; Ischemic Preconditioning, Myocardial; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Time Factors; Treatment Outcome; Vasodilator Agents | 2000 |
Nicorandil versus isosorbide dinitrate as adjunctive treatment to direct balloon angioplasty in acute myocardial infarction.
Topics: Angioplasty, Balloon; Chemotherapy, Adjuvant; Coronary Circulation; Double-Blind Method; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nicorandil; Prospective Studies; Treatment Outcome; Vasodilator Agents | 2004 |
Myocardial protective effects of nicorandil during percutaneous coronary intervention in patients with unstable angina.
Topics: Aged; Angina Pectoris; Angiography; Angioplasty, Balloon, Coronary; Biomarkers; Cardiotonic Agents; Echocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Stroke Volume; Treatment Outcome | 2005 |
Effects of nicorandil on cardiac sympathetic nerve activity after reperfusion therapy in patients with first anterior acute myocardial infarction.
Topics: 3-Iodobenzylguanidine; Angioplasty, Balloon, Coronary; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nicorandil; Prognosis; Radionuclide Imaging; Radiopharmaceuticals; Sympathetic Nervous System; Treatment Outcome; Vasodilator Agents; Ventricular Dysfunction, Left | 2005 |
Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis.
Topics: Administration, Oral; Arteriosclerosis; Brachial Artery; Disease Progression; Endothelium, Vascular; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Time Factors; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography; Vasodilation; Vasodilator Agents | 2005 |
Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy.
Topics: Female; Heart; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Sympathetic Nervous System; Ventricular Function, Left | 2005 |
Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; China; Double-Blind Method; Exercise; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Nitroglycerin; Vasodilator Agents | 2007 |
Impacts of nicorandil on infarct myocardium in comparison with nitrate: assessed by cardiac magnetic resonance imaging.
Topics: Aged; Biomarkers; Coronary Circulation; Coronary Vessels; Creatine Kinase, MB Form; Edema, Cardiac; Female; Humans; Isosorbide Dinitrate; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Nicorandil; Nitroglycerin; Percutaneous Coronary Intervention; Pilot Projects; Predictive Value of Tests; Time Factors; Treatment Outcome; Vasodilator Agents | 2016 |
Achieving Optimal Medical Therapy: Insights From the ORBITA Trial.
Topics: Amlodipine; Bisoprolol; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Fractional Flow Reserve, Myocardial; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Percutaneous Coronary Intervention; Ranolazine; Treatment Outcome; Vasodilator Agents | 2021 |
37 other study(ies) available for isosorbide dinitrate and nicorandil
| Article | Year |
|---|---|
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Nicorandil and cardiovascular performance in patients with coronary artery disease.
Topics: Administration, Sublingual; Coronary Circulation; Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilation; Vasodilator Agents; Ventricular Function, Left | 1992 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 1990 |
Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta.
Topics: Animals; Aorta; Calcium; Cyclic GMP; In Vitro Techniques; Ion Channels; Isosorbide Dinitrate; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rabbits | 1987 |
Nitrate tolerance: comparison of nicorandil, isosorbide dinitrate, and nitroglycerin in anesthetized dogs.
Topics: Anesthesia; Animals; Coronary Circulation; Dogs; Drug Tolerance; Female; Infusions, Intravenous; Injections, Intra-Arterial; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1987 |
Cyclic GMP in nicorandil-induced vasodilatation and tolerance development.
Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1987 |
Guanylate cyclase activation by organic nitrates is not mediated via nitrite.
Topics: Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Kinetics; Niacinamide; Nicorandil; Nitrates; Nitrites; Nitroglycerin; Sulfhydryl Compounds; Vasodilator Agents | 1988 |
Cardiovascular effects of isosorbide dinitrate infused intravenously into anaesthetized dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Female; Hemodynamics; Infusions, Intravenous; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin; Stroke Volume | 1986 |
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Isosorbide Dinitrate; Lypressin; Male; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Effects of nicorandil on rest and effort angina unresponsive to combination therapy with a calcium antagonist and oral nitrate.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Diltiazem; Drug Resistance; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Nifedipine; Physical Exertion; Prospective Studies; Rest; Vasodilator Agents | 1987 |
Salutary action of nicorandil, a new antianginal drug, on myocardial metabolism during ischemia and on postischemic function in a canine preparation of brief, repetitive coronary artery occlusions: comparison with isosorbide dinitrate.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucose; Hemodynamics; Isosorbide Dinitrate; Male; Myocardium; Niacinamide; Nicorandil; Oxygen; Recurrence | 1987 |
Comparative vasorelaxing profiles of nicorandil, isosorbide dinitrate and nitroglycerin in isolated coronary arteries of the dog.
Topics: Acetylcysteine; Animals; Coronary Vessels; Dinoprost; Dogs; Endothelium; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Chloride; Prostaglandins F; Vasodilator Agents | 1987 |
Effectiveness of nicorandil in the preservation of myocardium stressed by transient ischemia and its influence on cardiac metabolism during coronary artery occlusion with subsequent reperfusion: a comparison with isosorbide dinitrate.
Topics: Animals; Coronary Disease; Coronary Vessels; Dogs; Fatty Acids, Nonesterified; Glucose; Heart; Hemodynamics; Isosorbide Dinitrate; Lactates; Lactic Acid; Ligation; Myocardium; Niacinamide; Nicorandil; Perfusion | 1985 |
Hypotensive effects and biotransformation of nicorandil, a new antianginal agent, administered to rats by different routes: comparison with nitroglycerin and isosorbide dinitrate.
Topics: Animals; Antihypertensive Agents; Biotransformation; Blood Pressure; Dogs; Guinea Pigs; In Vitro Techniques; Isosorbide Dinitrate; Liver; Macaca mulatta; Male; Niacinamide; Nicorandil; Nitroglycerin; Rats; Rats, Inbred Strains; Swine; Vasodilator Agents | 1984 |
Effects of vasodilators on the systemic capacitance vessels, a study with the measurement of the mean circulatory pressure in dogs.
Topics: Animals; Blood Pressure; Blood Vessels; Blood Volume; Cardiac Output; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Prazosin; Sydnones; Trapidil; Vascular Resistance; Vasodilator Agents; Venous Pressure; Verapamil | 1984 |
Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathione S-transferase and lipid peroxidation.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase; Isosorbide Dinitrate; Lipid Peroxidation; Male; Microsomes, Liver; Niacinamide; Nicorandil; Nitroglycerin; Oxidation-Reduction; Propanolamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Sympathetic Nervous System; Vasodilator Agents | 1994 |
Effects of a novel, selective and potent phosphodiesterase type V inhibitor, E4021, on myocardial ischemia in guinea pigs.
Topics: Animals; Drug Interactions; Electrocardiography; Guinea Pigs; Injections, Intravenous; Isosorbide Dinitrate; Male; Myocardial Ischemia; Niacinamide; Nicorandil; Nitro Compounds; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Vasodilator Agents; Vasopressins | 1994 |
Effects of nitric oxide-containing compounds on increases in cytosolic ionized Ca2+ and on aggregation of human platelets.
Topics: Calcium; Cytosol; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Niacinamide; Nicorandil; Nitric Oxide; Platelet Aggregation; Sydnones | 1993 |
Limitation of myocardial infarct size by nicorandil after sustained ischemia in pigs.
Topics: Animals; Blood Pressure; Cardiac Output; Female; Glutathione; Heart Rate; Isosorbide Dinitrate; Male; Malondialdehyde; Myocardial Infarction; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Peroxidase; Potassium Channels; Pulmonary Wedge Pressure; Swine; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 1995 |
Comparison of proarrhythmogenic effects of two potassium channel openers, levcromakalim (BRL 38227) and nicorandil (RP 46417): a high-resolution mapping study on rabbit heart.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Bradycardia; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Heart; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rabbits; Tachycardia; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Successful management of intractable coronary spasm with a coronary stent.
Topics: Adult; Amlodipine; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm; Diltiazem; Doxazosin; Drug Resistance; Drug Therapy, Combination; Ergonovine; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nicorandil; Nitrates; Pyridines; Stents; Ticlopidine; Ventricular Fibrillation | 2000 |
The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil.
Topics: Adrenergic alpha-Antagonists; Amlodipine; Angioplasty, Balloon, Coronary; Animals; Aorta, Thoracic; Disease Models, Animal; Female; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Isosorbide Dinitrate; Muscle Relaxation; Muscle, Smooth, Vascular; Nicorandil; Nifedipine; Phentolamine; Platelet Aggregation Inhibitors; Postoperative Complications; Succinates; Vasodilator Agents | 2002 |
Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Coronary Artery Bypass; Coronary Vasospasm; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Infusions, Intravenous; Intracellular Signaling Peptides and Proteins; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Pain, Intractable; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases | 2004 |
Insulin resistance relates to acetylcholine-induced microvascular vasoconstriction in a patient with vasospastic angina: potential implication of causalities between hyperinsulinemia and coronary microcirculation failure.
Topics: Acetylcholine; Aged; Angina Pectoris; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; Electrocardiography; Humans; Hyperinsulinism; Infusions, Intra-Arterial; Insulin Resistance; Isosorbide Dinitrate; Male; Microcirculation; Nicorandil; Treatment Outcome; Vasoconstriction; Vasodilator Agents | 2005 |
The changes of fractional flow reserve after intracoronary nitrate and Nicorandil injection in coronary artery ectasia.
Topics: Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Coronary Disease; Coronary Vessels; Diagnosis, Differential; Dilatation, Pathologic; Female; Follow-Up Studies; Humans; Injections, Intra-Arterial; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Vasodilator Agents | 2006 |
Nicorandil but not ISDN upregulates endothelial nitric oxide synthase expression, preventing left ventricular remodeling and degradation of cardiac function in Dahl salt-sensitive hypertensive rats with congestive heart failure.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Heart Failure; Hypertension; Isosorbide Dinitrate; Male; Nicorandil; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Potassium Channels; Rats; Rats, Inbred Dahl; RNA, Messenger; Up-Regulation; Ventricular Remodeling | 2006 |
Intracoronary nicorandil relieves multiple coronary vasospasm with hemodynamic collapse.
Topics: Coronary Vasospasm; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Nicorandil; Shock; Ultrasonography; Vasodilator Agents; Verapamil | 2008 |
Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production.
Topics: Animals; Anti-Arrhythmia Agents; Arteries; Cells, Cultured; Chlorides; Collagen; Decanoic Acids; Endothelium, Vascular; Enzyme Inhibitors; Ferric Compounds; Humans; Hydroxy Acids; Isosorbide Dinitrate; Male; Mice; Mice, Inbred ICR; Mitochondria; NG-Nitroarginine Methyl Ester; Nicorandil; Nitric Oxide Synthase Type III; Oxidative Stress; Platelet Aggregation; Potassium Channels; Reactive Oxygen Species; Thrombosis; Umbilical Veins; Vasodilator Agents | 2009 |
Acute effects of isosorbide dinitrate and nicorandil on the coronary slow flow phenomenon.
Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Coronary Circulation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; No-Reflow Phenomenon; Prospective Studies; Vasodilator Agents | 2010 |
Variation assessment for in vitro permeabilities through Yucatan micropig skin.
Topics: Administration, Cutaneous; Animals; Biological Transport; Flurbiprofen; Humans; Isosorbide Dinitrate; Models, Animal; Nicorandil; Permeability; Pharmacokinetics; Skin Absorption; Swine; Swine, Miniature | 2011 |
Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study.
Topics: Administration, Topical; Adult; Analgesics; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diffusion; Female; Flurbiprofen; Humans; Isosorbide Dinitrate; Male; Middle Aged; Models, Animal; Nicorandil; Permeability; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Tandem Mass Spectrometry; Vasodilator Agents | 2011 |
Influence of skin thickness on the in vitro permeabilities of drugs through Sprague-Dawley rat or Yucatan micropig skin.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Flurbiprofen; In Vitro Techniques; Isosorbide Dinitrate; Male; Nicorandil; Permeability; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Swine; Tandem Mass Spectrometry | 2012 |
Recurrent ventricular fibrillation under sufficient medical treatment in patient with coronary artery spasm.
Topics: Cardiovascular Agents; Coronary Vasospasm; Defibrillators, Implantable; Diagnosis, Differential; Diltiazem; Echocardiography; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Middle Aged; Nicorandil; Recurrence; Treatment Outcome; Ventricular Fibrillation | 2013 |
A case of vasospastic angina in which the ergonovine provocation test with intracoronary isosorbide dinitrate and nicorandil was effective in the diagnosis of microvascular spasm.
Topics: Angina Pectoris; Coronary Angiography; Coronary Vasospasm; Electrocardiography; Ergonovine; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Oxytocics; Vasodilator Agents | 2014 |
Aborted sudden cardiac death due to intractable ventricular fibrillation caused by coronary spasm refractory to implantable cardioverter defibrillator therapy.
Topics: Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Coronary Angiography; Coronary Stenosis; Coronary Vasospasm; Death, Sudden, Cardiac; Defibrillators, Implantable; Echocardiography; Electrocardiography; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Prognosis; Receptors, Calcium-Sensing; Vasodilator Agents; Ventricular Fibrillation | 2014 |
[Comparative Assessment of Effects of Isosorbide Dinitrate, Isosorbide-5-Mononitrate and Nicorandil on the Frequency of Angina Attacks and Vasoregulating Endothelial Function in Patients With Ischemic Heart Disease].
Topics: Adult; Aged; Angina Pectoris; Electrocardiography; Female; Humans; Incidence; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Risk Assessment; Russia; Vasodilation | 2015 |