isosorbide dinitrate has been researched along with isosorbide-5-mononitrate in 830 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 219 (26.39) | 18.7374 |
| 1990's | 258 (31.08) | 18.2507 |
| 2000's | 234 (28.19) | 29.6817 |
| 2010's | 100 (12.05) | 24.3611 |
| 2020's | 19 (2.29) | 2.80 |
| Authors | Studies |
|---|---|
| Jolivette, LJ; Ward, KW | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Kurosaki, M; Latini, R; Riva, E | 1 |
| Döring, G | 1 |
| Wagner, G | 1 |
| Carboni, GP; Prati, PL; Risa, AL; Saltarocchi, ML; Scardovi, AB; Zanchi, E | 1 |
| Schmid, M; Yeates, RA | 1 |
| Atanassova, R; Balansky, R; Boev, K; Spassov, G | 1 |
| D'Aprile, N; Faglia, S; Kristodhullo, A; Mondillo, S; Palazzuoli, V | 1 |
| Janicki, S; Sawicki, W | 1 |
| Bohn, H; Martorana, PA; Schönafinger, K | 1 |
| Humar, F; Mazzone, C; Pandullo, C; Scardi, S; Spanghero, M | 1 |
| Abshagen, UW | 1 |
| de Vane, PJ; Thadani, U | 1 |
| Bartsch, W; Neidlein, R; Pressmar, F; Strein, K | 1 |
| Düring, C; Geppert, R; Jansen, W; Prenzel, R; Rappert, B | 1 |
| Ganzinger, U | 1 |
| Werkö, L | 1 |
| Garre, K; Iversen, HK; Nielsen, TH; Olesen, J; Tfelt-Hansen, P | 1 |
| Fernández, N; Martinez, A; Pedrote, A; Sobrino, JM | 1 |
| Fung, HL; Tzeng, TB | 3 |
| Keller-Stanislawski, B; Marschner, JP; Rietbrock, N | 1 |
| Harder, S; Merz, PG; Thürmann, P | 1 |
| De Sutter, J; De Wilde, G; Duprez, D; Lefebvre, RA; Pocchiari, F; Rosseel, MT | 1 |
| Allgén, J; Amtorp, O; Nyberg, G; Olsson, G; Parker, JO | 1 |
| Bittar, N; Thadani, U | 1 |
| Jähnchen, E | 1 |
| Bonn, R; Fritschi, E; Hutt, V; Jaeger, H; Pabst, G; Theodor, R | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B; Valta-Seufzer, U | 1 |
| Gessner, C; Hain, P; Mitrovic, V; Müller, KD; Schlepper, M | 1 |
| Akhras, F; Jackson, G | 1 |
| Araki, Y; Furuno, K; Gomita, Y | 4 |
| Akhras, F; Eteiba, H; Foale, RA; Hallam, RJ; Hutton, I; Jackson, G; Prescott, RJ; Quinn, KJ | 1 |
| Gendel'man, AM; Lazebnik, LB; Tereshchenko, SN | 1 |
| Bulitta, M; Hilbich, K; Krepp, P; Neuhaus, R; Patyna, WD; Puespoek, J; Rittinghausen, R; Ueberbacher, HJ | 1 |
| Krepp, HP | 1 |
| Brunner, D; Meshulam, N; Waysbort, J | 1 |
| Koch, JE; Ontanilla, E; Yasky, J | 1 |
| Beck, EJ; Koch, JE | 1 |
| Ahmadinejad, M; Eghbal, B; Ensslin, HD; May, K; Weiss, M | 1 |
| Keck, M | 1 |
| Jansen, W; Kümper, H; Laufen, H; Prenzel, R; Rappert, B; Tauchert, M | 1 |
| Drummer, C; Frey, A; Gerzer, R; Lüdke, S; Schramm, W; Spannagl, M; Valta-Seufzer, U | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B; Niederreiter, B | 1 |
| Bron, J; De Jong, AP; Jonkman, JH; Oosterhuis, B; Storm, G; Wittebrood, AJ | 1 |
| Gazarian, GA; Golikov, AP; Spasskiĭ, AA | 1 |
| Bachmann, K; Wortmann, A | 2 |
| Lemmer, B; Scheidel, B | 1 |
| Azcona, T; Garcia de Mirasierra, M; Grau, C; Martin-Gonzalez, A; Pascual, C; Zamorano, P | 1 |
| Marmor, AT; Schneeweiss, A | 1 |
| Cadeddu, M; Cherchi, A; Lai, C; Lai, G; Onnis, E; Orani, E; Solinas, R | 1 |
| Babej-Dölle, RM; Blume, H; Scheidel, B; Siewert, M; Stenzhorn, G | 1 |
| Parker, JO | 4 |
| Andresen, D; Brüggemann, T; Hennig, A; Hennig, L; Levenson, B; Schröder, R | 1 |
| Anggård, E; Arvill, A; Jörgensen, E | 1 |
| Nyberg, G | 2 |
| Holzmann, S; Kukovetz, WR | 2 |
| Colardyn, F; De Muynck, C; Remon, JP | 1 |
| Behne, S; Lemmer, B; Scheidel, B | 1 |
| Bosch, J; Feu, F; García-Pagán, JC; Rodés, J | 1 |
| Hůla, J; Trhlíková, M | 1 |
| Heidemann, HT; Meissner, A; Osterkamp, U; Petersenn, S; Schulte, HM; Simon, R | 1 |
| Becker, HJ; Blume, H; Lemmer, B; Scheidel, B | 1 |
| Jansen, W; Tauchert, M | 1 |
| Avila Escribano, C; Cascón Bueno, M; Diego Domínguez, M; Fernández Esteban, T; Martín Luengo, C; Nieto Ballesteros, F; Pavón Osuna, P; Santos Rodríguez, I | 1 |
| Jonsson, UE | 2 |
| Silber, S | 2 |
| Dirschinger, J; Hall, D; Rudolph, W | 1 |
| Bosch, J; Bru, C; Feu, F; García-Pagán, JC; Navasa, M; Rodés, J; Ruiz del Arbol, L | 1 |
| Bennett, BM; Booth, BP; Brien, JF; Elliott, DA; Marks, GS; McCans, JL; Nakatsu, K | 1 |
| Flatmark, T; Grønberg, M; Husebye, ES; Terland, O | 1 |
| Bennett, ED; Fitzgerald, LJ | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B | 1 |
| Adao, M; Aleixo, AM; Bruges, G; Machado, FP; Mendes, M; Palos, JL; Seabra-Gomes, R | 1 |
| Feng, JZ; Feng, XH; Schneeweiss, A | 1 |
| Batinić, Z; Goldner, V; Pavicić, L; Rezaković, DE; Stalec, J; Weiss, M | 1 |
| Beyerle, A; Reiniger, G; Rudolph, W | 1 |
| Kendall, MJ | 2 |
| Gross, W; Messmer, K; Schosser, R | 1 |
| Blagodatskikh, SV; Egorov, LV; Martsevich, SIu; Metelitsa, VI; Simkhaev, LS; Slastnikova, ID | 1 |
| Bosch, J; Bru, C; Garcia-Pagán, JC; Navasa, M; Pizcueta, P; Rodés, J | 1 |
| Bernini, W; De Caterina, R; Giannessi, D; Lazzerini, G; Lombardi, M; Mazzone, A; Moscarelli, E; Weiss, M | 1 |
| Boniforti, L; Pacifici, R; Pichini, S; Zuccaro, P; Zuccaro, SM | 1 |
| Heidemann, R; Kaltenbach, M; Menke, G; Rietbrock, N; Satter, P; Schneider, W | 1 |
| Jansen, W; Kümper, H; Prenze, R; Tauchert, M | 1 |
| Adam, WE; Grossmann, G; Stauch, M; Wanjura, D | 1 |
| Jähnchen, E; Siefert, F; Trenk, D; Wagner, F | 1 |
| Wrobel, N | 1 |
| Bushe, CJ | 1 |
| Bernini, W; De Caterina, R; Giannessi, D; Mazzone, A | 2 |
| Aldershvile, J; Klarlund, K; Svendsen, JH; Waldorff, S | 1 |
| Abildgaard, U; Aldershvile, J; Amtorp, O; Svendsen, JH | 1 |
| DasGupta, P; Hughes, LO; Jain, D; Lahiri, A; Raftery, EB | 1 |
| Bayeric, A; Dirschinger, J; Hall, D; Reiniger, G; Rudolph, W | 1 |
| Akhras, F; Chambers, J; Jackson, G; Jefferies, S | 1 |
| Ake, H; Arina, R; Emanuelsson, H; Kristi, M | 1 |
| Bernini, W; De Caterina, R; Giannessi, D; Lazzerini, G; Lombardi, M; Mazzone, A | 1 |
| Jansen, W; Kümper, H; Prenzel, R; Tauchert, M; Weidmann, B | 1 |
| Ahlner, J; Axelsson, KL; Torfgård, K | 1 |
| Becker, HJ; Blume, H; Grether, D; Lemmer, B; Lenhard, G; Renczes, J; Scheidel, B; Stenzhorn, G | 1 |
| De Magalhães, HM; Gun, C; Piegas, LS; Ramos, RF; Romano, ER; Sousa, JE; Timerman, A; Timerman, S | 1 |
| Bonn, R; Muck, B; Rietbrock, N | 1 |
| Daskalov, TR | 1 |
| Liu, WY | 1 |
| Caporale, R; Lagioia, R; Loliva, F; Mancini, G; Mangini, SG; Mastropasqua, F; Rizzon, P; Scrutinio, D | 1 |
| Beyerle, A; Dirschinger, J; Reiniger, G; Rudolph, W | 1 |
| Barillà, F; Ciolli, A; Ferraironi, A; Pannarale, G; Pelliccia, F; Romeo, F; Valente, A; Vicchio, D | 1 |
| Schaumann, W | 2 |
| Behrenbeck, T; Bender, F; Brisse, B; Ebert, U; Navah, R | 1 |
| Boertz, A; Bonn, R; Cawello, W; Dickmans, HA; Evers, J; Weiss, M | 1 |
| Krakauer, J; Marmor, A; Schneeweiss, A | 1 |
| Giannellini, V; Gratteri, P; La Porta, E; Papeschi, G; Pinzauti, S | 1 |
| Krivoshieva, Z; Petrova, V; Prodanov, A; Taskov, M | 1 |
| Akpan, W; Jaeger, H; Lutz, D; Mosberg, H; Neugebauer, G; Stemmle, B | 1 |
| Böttcher, B; Brandt, L; Skutta, T | 1 |
| Assereto, R; Baggio, E; Gandini, R; Maraffi, F; Massari, D; Megali, R; Montella, S; Pozzoli, G; Vargiu, B | 1 |
| Chang, TT; Kong, CW; Lay, CS; Lee, FY; Lee, SD; Lin, HC; Lo, KJ; Tsai, YT; Wang, SS | 1 |
| Borella, F; Comini, A; Coppi, G; Dall' Asta, L; Gatti, MT | 1 |
| Fay, L; Michel, G; Prost, M | 1 |
| Goddard, MD; Nichol, P; Roks, C; Wisenberg, G | 1 |
| Betriú, A; Cloquell, G; González Maqueda, I; López-Sendón, J; Martín Jadraque, L; Mont, J; Sanz, G | 1 |
| Bhans, A; Debbas, N; Dews, I; Jubber, A; Marks, C; Stephens, J; Vandenburg, M; Woodings, D | 1 |
| Greenblatt, DJ; Labedzki, L; Neugebauer, G; Ochs, HR | 1 |
| Holzmann, S; Kukovetz, WR; Romanin, C | 1 |
| Uusitalo, A | 1 |
| Aberg, A; Engvall, J; Härkönen, R; Keyriläinen, O; Nyberg, G; Olsson, G; Rehnqvist, N; Rosenqvist, U; Ulvenstam, G; Uusitalo, A | 1 |
| Amtorp, O; Svendsen, JH | 1 |
| Aberg, A; Engvall, J; Härkönen, R; Keyriläinen, O; Nyberg, G; Rautio, P; Rehnqvist, N; Rosenqvist, U; Ulvenstam, G; Uusitalo, A | 1 |
| Bosch, J; Chesta, J; Navasa, M; Rodés, J | 1 |
| Brambilla, M; Centonze, F; Pittana, P; Sega, R; Serra, G | 1 |
| Matsuoka, I; Nakanishi, H; Sakurai, K | 1 |
| Cherchi, A; Lai, C; Onnis, E; Orani, E; Pirisi, R; Soro, A | 1 |
| Hisayama, T; Takayanagi, I; Toyoda, J | 2 |
| Johnen, R; Neuhaus, R; Solbach, C; Vydra, L | 1 |
| Berenger, FP; Cano, JP; Rolland, PH | 1 |
| Gathmann-Lewik, U; Heepe, W | 1 |
| De Martini, M; Foresti, A; Lotto, A; Massari, FM; Valentini, R | 1 |
| Fung, HL | 2 |
| Schneeweiss, A | 1 |
| Ambrosioni, E; Strocchi, E | 1 |
| Thadani, U; Whitsett, T | 1 |
| Ahmadinejad, M; Eghbal, B; Schneeweiss, A; Sorgenicht, W; Weiss, M | 1 |
| Bogaert, MG | 2 |
| Beyerle, A; Dirschinger, J; Hall, D; Reiniger, G; Rudolph, W | 1 |
| Aberg, A; Engvall, J; Keyriläinen, O; Nyberg, G; Olsson, G; Rehnqvist, N; Reinikainen, P; Rosenqvist, U; Ulvenstam, G; Uusitalo, A | 1 |
| Bogaert, MG; Bouckaert, J; Lefebvre, RA; Rosseel, MT | 1 |
| Laufen, H; Leitold, M; Wildfeuer, A | 1 |
| Bleifeld, W; Erlemeier, HH; Hempel, NB; Kupper, W | 1 |
| Erath, A; von Arnim, T | 1 |
| Alaimo, G; Centineo, G; Licata, G; Nardi, E; Novo, S; Strano, A | 1 |
| Gathmann-Lewik, U; Kenedi, P | 1 |
| von Arnim, T | 1 |
| Chasseaud, LF | 2 |
| Crake, T; Fox, KM; Mockus, LJ; Quyyumi, AA; Wright, CM | 1 |
| Bidoggia, H | 1 |
| Bonn, R | 1 |
| Harf, C; Welter, R | 1 |
| Jansen, W; Meyer, L; Tauchert, M | 1 |
| Green, ST; Miller, SH; Thomson, AH; Whiting, B | 1 |
| Hayes, PC; Westaby, D; Williams, R | 1 |
| Calvi, V; Felis, S; Giuffrida, G; Grassi, R; Greco, G; Monaco, A; Monaco, O; Russo, G; Tamburino, C; Tolaro, S | 1 |
| Erath, A; Reuschel-Janetschek, E; von Arnim, T | 1 |
| Eckel, L; Kaltenbach, M; Kober, G; Schneider, W; von Loh, D | 1 |
| Chouraqui, P; Katz, A; Neufeld, HN; Rabinowitz, B; Shotan, A | 1 |
| Berenger, FP; Bodard, H; Friggi, A; Rolland, PH | 1 |
| Daskalov, T | 1 |
| Herrmann, H; Kuhl, A; Maier-Lenz, H | 1 |
| Geppert, R; Jansen, W; Tauchert, M; Weidmann, B | 1 |
| Menke, G; Rietbrock, N; Schnellhammer, R | 1 |
| Assereto, R; Baggio, E; Castoldi, D; Cunietti, E; Gandini, R; Tofanetti, O | 2 |
| Amico, C; Bosimini, E; Schiavoni, G | 1 |
| Fazzini, PF; Pucci, P | 1 |
| Canale, C; Caponnetto, S; Masperone, MA; Terrachini, V | 1 |
| Boertz, A; Cawello, W; Cordes, G; Davis, SS; Fischer, W; Khosla, R; Sandrock, K | 1 |
| Burkhardt, H; Deuster, U; Loew, D; Rietbrock, N | 1 |
| Aberg, A; Aström, H; Carlens, P; Lindström, E; Lundman, T; Nordlander, R; Nyberg, G; Rehnqvist, N; Ulvenstam, G | 2 |
| Bleifeld, W; Erlemeier, HH; Kupper, W; Lange, S | 1 |
| Distante, A; L'Abbate, A; Lombardi, M; Morales, MA; Moscarelli, E | 2 |
| Kenedi, P | 1 |
| Cannizzaro, S; Davì, G; Giubilato, A; Mattina, A; Novo, S; Strano, A | 1 |
| Kanto, JH | 1 |
| Gracien, E; Heidemann, R; Menke, G; Rietbrock, N | 1 |
| Adams, CB; Bevan, JS; Burke, CW; Oza, AM | 1 |
| Furuzawa, T; Imaeda, N; Mizukami, Y; Sugiyama, T; Yamazoe, K; Yasuda, K | 1 |
| Doyle, R; Hamilton, SF; Karpow, SA; Prasad, R; Reder, R; Teague, SM; Thadani, U; Voyles, WF | 1 |
| Gammage, MD; Murray, RG | 1 |
| Hutton, I; Martin, W; McGhie, AI; Tweddel, AC | 2 |
| Marks, C; Stephens, JD; Vandenburg, MJ; Woodings, D | 1 |
| Meffert, M; Paeckelmann, IM | 1 |
| Aboudan, F; Boertz, A; Bonn, R; Cawello, W; Dickmans, HA; Evers, J; Fey, M; Luckow, V | 1 |
| Doyle, R; Hamilton, SF; Karpow, S; Prasad, R; Reder, R; Teague, SM; Thadani, U; Voyles, W | 1 |
| Brunner, D; Meshulam, N; Weisbort, J | 1 |
| Kogi, K; Satoh, T | 1 |
| Agranat, O; Chouraqui, P; Hod, H; Neufeld, HN; Rabinowitz, B; Rath, S | 1 |
| Gammage, MD; Littler, WA; Murray, RG | 1 |
| Kamihara, S; Kitamura, J; Koide, M; Miyahara, T; Noda, S; Sotobata, I; Tsunekawa, A; Tsuzuki, M; Yokota, M | 1 |
| Cawello, W; Dickmans, HA; Evers, J; Klimkait, W; Krakamp, B; Luckow, V; Maddock, J; Weiss, M | 1 |
| Cano, JP; Frances, Y; Iliadis, A; Luccioni, R; Santoni, Y | 1 |
| Kardash, MM; Kohli, RS; Raftery, EB; Rodrigues, EA; Whittington, JR | 1 |
| Eggeling, T; Hilger, HH; Jansen, W; Osterspey, A; Tauchert, M | 1 |
| Bassenge, E; Strein, K | 1 |
| Anderson, JL; Doyle, R; Hamilton, SF; Kirsten, E; Olson, E; Prasad, R; Teague, SM; Thadani, U; Voyles, W | 1 |
| Cherchi, A; Lai, C; Meloni, L; Onnis, E; Pirisi, R | 1 |
| Bacher, S; Beck, A; Kraupp, O; Raberger, G; Skoda, H | 1 |
| Kamata, T; Kimura, K; Nagatsuka, K; Nakabayashi, S; Uehara, A; Uyama, O; Wanaka, A; Yoneda, S | 1 |
| Knoll, J; Menke, G; Merz, PG; Rietbrock, N | 1 |
| De Caterina, R; Dorso, CR; Tack-Goldman, K; Weksler, BB | 1 |
| Grosswendt, J; Klütsch, K; Koch, E; Schöniger, F | 1 |
| Gleichmann, U; Kabelitz, K; Mannebach, H; Mertens, HM; Ohlmeier, H | 1 |
| Brodie, NH; O'Hara, H; O'Hara, J; Valle-Jones, JC | 1 |
| Akhras, F; Jackson, G; Jefferies, S | 1 |
| Abshagen, U; Betzien, G; Endele, R; Kaufmann, B; Neugebauer, G | 1 |
| Gielsdorf, W; Jaeger, H; Loew, D; Lutz, VD; Rasper, J | 1 |
| Galeazzi, RL; Straehl, P | 2 |
| Accettura, D; Antuofermo, F; De Nicolò, M; De Toma, L; Lagioia, R; Mangini, SG; Preziusi, N; Rizzon, P; Saliani, P; Scrutinio, D | 1 |
| Abildgaard, U; Aldershvile, J | 1 |
| Neugebauer, G; von Möllendorff, E | 1 |
| Kogi, K; Saito, T | 1 |
| Marzo, A; Treffner, E | 1 |
| Kozák, P | 1 |
| Bacher, S; Eichler, HG; Horwatitsch, H; Rameis, H | 1 |
| Thadani, U | 2 |
| Distante, A; L'Abbate, A; Lombardi, M; Morales, MA; Moscarelli, E; Sabino, F | 1 |
| Dietmann, K; Sponer, G; Voss, E | 2 |
| Glocke, M; Müller, G; Uberbacher, HJ | 1 |
| Haase, W; van Hasselt, P; Weiss, M | 1 |
| Blasini, R; Brügmann, U; Reiniger, G; Rudolph, W | 1 |
| Abshagen, U; Glocke, M; Uberbacher, HJ | 1 |
| Häcker, W; Müller, G; Schneider, B | 1 |
| Bussmann, WD | 1 |
| Kayali, A | 1 |
| Kreye, VA; Stiefel, A | 2 |
| Jansen, W; Metternich, M; Osterspey, A; Tauchert, M | 1 |
| Fung, HL; Morrison, RA | 2 |
| Abshagen, U; Dietmann, K; Sponer, G; Strein, K | 1 |
| Haase, W; van Hasselt, M; Weiss, M | 1 |
| Haase, W; Marten, W; Weiss, M | 1 |
| Galeazzi, RL; Soliva, M; Straehl, P | 1 |
| Bennett, BM; Brien, JF; Marks, GS; Nakatsu, K; Tam, GS; Van Alstyne, K | 1 |
| Georgieva, R; Mikhaĭlova, D; Naplatanova, D; Ognianova, V; Velikova, E | 1 |
| Laufen, H; Leitold, M | 1 |
| Bonn, R; Chasseaud, LF; Darragh, A; Forrest, ME; John, BA; Lambe, RF; Major, RM; Wood, SG | 1 |
| Chasseaud, LF; Cook, SC; Darragh, A; Lambe, RF; Leaf, FC; Major, RM; Taylor, T | 1 |
| Bussmann, WD; Kaltenbach, M; Schneider, W; Stahl, B | 1 |
| Jahed, M | 1 |
| Chasseaud, LF; Darragh, A; Doyle, E; Lambe, RF; Taylor, T | 1 |
| Jobst, E; Keller, H; Schmidt, G | 1 |
| Bernhardt, S; Kreuzer, H; Schwarck, H; Stroh, E; Vogt, A | 1 |
| Fuchs, M; Hilger, HH; Hombach, V; Jansen, W; Osterspey, A; Tauchert, M | 1 |
| Steudel, AT; Steudel, HC; Volkenandt, M | 1 |
| Schuster, P; Trieb, G; Wiechmann, HW | 2 |
| Hirzel, HO; Krayenbuehl, HP; Stoffel, P | 1 |
| Bogaert, MG; Bruyneel, K; Rosseel, MT | 2 |
| Aumann, M; Laufen, H; Leitold, M | 1 |
| Bartsch, W; Dietmann, K; Endele, R; Kühnle, HF; Sponer, G; Strein, K | 1 |
| Rietbrock, N; Woodcock, BG | 1 |
| Pommier, F; Sioufi, A | 1 |
| Bartsch, W; Lexa, P; Müller-Beckmann, B; Sponer, G; Strein, K | 1 |
| Chasseaud, LF; Darragh, A; Lambe, RF; Major, RM; Taylor, T | 1 |
| Cano, JP; Rolland, PH; Santoni, Y | 1 |
| Bartsch, W; Dietmann, K; Müller-Beckmann, B; Sponer, G; Strein, K | 1 |
| Chasseaud, LF; Major, RM; Taylor, IW; Taylor, T | 1 |
| Glocke, M; Seeliger, S; Smolarz, A | 1 |
| Fuchs, M; Hombach, V; Jansen, W; Osterspey, A; Schell, U; Tauchert, M; Weste, S | 1 |
| Kochsiek, K; Schanzenbächer, P | 1 |
| Bergbauer, M | 1 |
| Schmidt, G | 1 |
| Degen, J; Geigenberger, A; Maier-Lenz, H | 1 |
| Fuchs, M; Hilger, HH; Hombach, V; Jansen, W; Osterspey, A; Schell, U; Schmid, G; Tauchert, M | 1 |
| Kimura, T; Kogi, K; Saito, T; Tanaka, O | 1 |
| Heeg, E; Langner, A | 1 |
| Bartsch, W; Dietmann, K; Strein, K | 1 |
| Biamino, G; Nöring, J | 1 |
| Abshagen, U; Betzien, G; Endele, R; Kaufmann, B; Spörl-Radun, S | 1 |
| Abshagen, U; Gleichmann, U; Mannebach, H; Ohlmeier, H; von Möllendorff, E | 1 |
| Abshagen, U; Klotschkoff, P; Kösters, W | 1 |
| Bussmann, WD; Kaltenbach, M; Reifart, F; Reifart, N | 1 |
| Kübler, W; Manthey, J; Mehmel, HC; Ruffmann, K; Schwarz, F | 1 |
| Doering, W; Greding, H; Isbary, J; König, E; Wauer, B | 1 |
| Andresen, D; Arntz, R; Biamino, G; Lichey, HJ; Oeff, M; Prokein, E; Schröder, R; von Leitner, E | 1 |
| Bussmann, WD; Kaltenbach, M; Reifart, N; Schirmer, M | 1 |
| Bödigheimer, K; Delius, W; Nowak, FG | 1 |
| Müller, G; Schmidt-Voigt, J | 1 |
| Abshagen, U; Spörl-Radun, S | 1 |
| Abshagen, U; Betzien, G; Endele, R; Kaufmann, B | 1 |
| Andrews, R; Cowley, AJ; Evans, A; Walsh, JT | 1 |
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| Baum, C; Daiber, A; Hausding, M; Helmstädter, J; Iglarz, M; Jansen, T; Kashani, F; Kröller-Schön, S; Münzel, T; Oelze, M; Roohani, S; Schulz, E; Steven, S | 1 |
| Butler, J; Felker, GM; Patel, RB; Redfield, MM; Shah, SJ; Vaduganathan, M | 1 |
| Ghaffarian Omid, M; Mirteimouri, M; Najaf Najafi, M; Pourali, L | 1 |
| Chen, M; Jiang, Z; Li, Y; Peng, Y; Shi, S; Song, J | 1 |
| Cheng, G; Liu, X; Xu, J; Zhang, G | 1 |
| Ding, Y; Han, Z; He, Q; Hu, H; Jia, R; Liu, A; Liu, B; Wang, H; Wu, N; Ye, X; Zhang, F; Zhou, Y; Zhou, Z | 1 |
| Jangjoo, S; KaramiAbd, T; Kashanian, M; Sheikhansari, N | 1 |
| Abbas, AM | 1 |
| Afifi, AN; El-Khayat, WM; Taymour, MA | 1 |
| Al-Lamee, R; Davies, JR; Foley, M; Francis, DP; Ganesananthan, S; Gerber, R; Howard, J; Keeble, TR; Malik, IS; Nijjer, S; Nowbar, AN; O'Kane, P; Petraco, R; Rajkumar, CA; Seligman, H; Sen, S; Sharp, ASP; Shun-Shin, M; Tang, KH | 1 |
| Cackovic, H; Gee, SE; Landon, MB; Ma'ayeh, M; Rood, KM; Samuels, P; Thung, SF | 1 |
| Abad Pérez, D; Bellisco Roncal, S; García Polo, I; Ibáñez Sanz, P; Rodríguez Salvanés, FJ; Suárez Fernández, C | 1 |
| Ding, P; Dong, D; Huang, S; Li, C; Liu, S; Zhang, Y; Zhao, Y | 1 |
| Cheng, Z; Tan, Y; Wang, L; Zhang, G; Zhang, L | 1 |
| Appleton, JP; Bath, PM; Blair, GW; Chappell, F; Doubal, FN; Flaherty, K; Hamilton, I; Janssen, E; Shi, Y; Stringer, MS; Thrippleton, MJ; Wardlaw, JM | 1 |
| Liu, W; Meng, Z; Wang, G | 1 |
| Becker, C; Besche, N; Boettcher, M; Donath, F; Düngen, HD; Gerrits, M; Hung, J; Karakas, M; Mikus, G; Schulz-Burck, D; Trenk, D; Werner, N | 1 |
| Akhtar, MF; Khan, MI; Riaz, A; Saleem, A; Sharif, H; Sharif, Z | 1 |
| Abdulmalik, NA; Abu-Zaid, A; Abuzaid, M; Al-Matary, A; Albadawi, MI; Almubarki, AA; Almugbel, M; Alomar, O; Alrasheed, MA; Alshahrani, MS; Baradwan, A; Baradwan, S; Jamjoom, MZ; Khadawardi, K; Miski, NT; Salem, A; Salem, R; Tulbah, M | 1 |
| Cai, X; He, L; Li, G; Ling, M; Liu, Q; Mai, Z; Sun, R; Wang, X; Xiao, Y; Yang, W; Yu, K; Yu, Z; Zhong, M | 1 |
| Cheng, G; Gu, Z; Liu, H; Qiu, J; Xu, L; Zheng, H; Zhuang, D | 1 |
66 review(s) available for isosorbide dinitrate and isosorbide-5-mononitrate
| Article | Year |
|---|---|
Pharmacokinetics of isosorbide mononitrate.
Topics: Drug Administration Schedule; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1992 |
Efficacy of isosorbide mononitrate in angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1992 |
[Tolerance in treatment with nitrates].
Topics: Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Risk Factors | 1992 |
Nitrate tolerance--can it be prevented?
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates | 1991 |
Clinical experience with Imdur in angina pectoris. A review.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Delayed-Action Preparations; Drug Interactions; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitroglycerin | 1990 |
Chronopharmacokinetics and chronopharmacodynamics of cardiovascular active drugs. Propranolol, organic nitrates, nifedipine.
Topics: Animals; Circadian Rhythm; Humans; Isosorbide Dinitrate; Nifedipine; Propranolol | 1991 |
Development of long-acting nitrate delivery systems.
Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
Nitrates: why and how should they be used today? Current status of the clinical usefulness of nitroglycerin, isosorbide dinitrate and isosorbide-5-mononitrate.
Topics: Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
[Nitrates in the treatment of heart failure].
Topics: Dose-Response Relationship, Drug; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1990 |
[Inhibition of platelet aggregation by endothelium-derived relaxing factor-like agents].
Topics: Animals; Coronary Circulation; Humans; Isosorbide Dinitrate; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1990 |
Long-term therapeutic efficacy with once-daily isosorbide-5-mononitrate (Imdur).
Topics: Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate | 1990 |
[Long-term therapy with nitrates. How can continuous effectiveness be achieved?].
Topics: Administration, Cutaneous; Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Nitrates | 1989 |
Pharmacokinetics of isosorbide dinitrate and isosorbide-5-mononitrate.
Topics: Biological Availability; Half-Life; Humans; Isosorbide Dinitrate | 1989 |
Pharmacokinetics and pharmacodynamics of organic nitrates.
Topics: Animals; Cardiac Output; Half-Life; Humans; Isosorbide Dinitrate; Metabolic Clearance Rate; Nitroglycerin | 1987 |
[Slow-release nitrates: a critical review].
Topics: Coronary Disease; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nitroglycerin | 1987 |
Relationship of pharmacokinetic and pharmacodynamic properties of the organic nitrates.
Topics: Angina Pectoris; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Nitroglycerin | 1988 |
Pharmacokinetics of organic nitrates in man: an overview.
Topics: Absorption; Administration, Cutaneous; Administration, Sublingual; Humans; Injections, Intravenous; Isosorbide Dinitrate; Nitroglycerin | 1988 |
Isosorbide 5-mononitrate pharmacokinetics.
Topics: Humans; Isosorbide Dinitrate; Kinetics; Protein Binding | 1987 |
Various administration forms of nitrates and their possibilities.
Topics: Administration, Cutaneous; Aerosols; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Kinetics; Nitrates | 1987 |
The therapeutic role of isosorbide-5-mononitrate+ in stable and unstable angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate | 1986 |
[Acute and long-term nitrate treatment of angina pectoris].
Topics: Acute Disease; Administration, Oral; Angina Pectoris; Bandages; Drug Tolerance; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Long-Term Care; Mouth Floor; Nitroglycerin; Ointments | 1983 |
Pharmacologic therapy of angina pectoris.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Drug Therapy, Combination; Enoximone; Heparin; Humans; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Piperazines; Ranolazine; Vasodilator Agents | 1995 |
Short and long-acting oral nitrates for stable angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; United States; United States Food and Drug Administration; Vasodilator Agents | 1994 |
Clinical pharmacokinetics of nitrates.
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Administration Routes; Half-Life; Humans; Isosorbide Dinitrate; Liver; Nitrates; Nitroglycerin; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1994 |
Mechanisms of action of nitrates.
Topics: Angina Pectoris; Blood Platelets; Cyclic GMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Esterases; Glutathione Transferase; Heart; Heart Failure; Humans; Isosorbide Dinitrate; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Infarction; Nitrates; Nitroglycerin; Oxygen Consumption; Structure-Activity Relationship; Vasodilator Agents | 1994 |
Nitrate therapy and the development of tolerance.
Topics: Angina Pectoris; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilator Agents | 1993 |
Organic nitrates in portal hypertension.
Topics: Animals; Collateral Circulation; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Nitrates; Nitroglycerin; Vasodilator Agents | 1994 |
NO-donors and angina pectoris: more than just symptomatic treatment?
Topics: Angina Pectoris; Animals; Endothelium, Vascular; Free Radicals; Humans; Isosorbide Dinitrate; Nitric Oxide; Vasodilation; Vasodilator Agents | 1997 |
Achieving sustained improvement in myocardial perfusion: role of isosorbide mononitrate.
Topics: Angina Pectoris; Coronary Circulation; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1997 |
Nitrate therapy for stable angina pectoris.
Topics: Angina Pectoris; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Vasodilator Agents | 1998 |
Cervical ripening after nitric oxide.
Topics: Animals; Cervix Uteri; Female; Humans; Isosorbide Dinitrate; Labor Stage, First; Nitric Oxide; Nitroglycerin; Nitroprusside; Pregnancy; Uterine Contraction | 1998 |
Clinical pharmacokinetics of vasodilators. Part II.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Alprostadil; Amrinone; Carbazoles; Carvedilol; Enoximone; Female; Humans; Iloprost; Imidazoles; Indoramin; Isosorbide Dinitrate; Labetalol; Milrinone; Molsidomine; Nitroglycerin; Nitroprusside; Oxyfedrine; Pentaerythritol Tetranitrate; Phosphodiesterase Inhibitors; Piperazines; Prazosin; Pregnancy; Propanolamines; Pyridones; Theophylline; Trapidil; Vasodilator Agents | 1998 |
Medical decompressive therapy for prophylaxis of rebleeding.
Topics: Adrenergic beta-Antagonists; Combined Modality Therapy; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Esophageal and Gastric Varices; Esophagoscopy; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Recurrence; Sclerotherapy; Vasodilator Agents | 1998 |
Long-acting isosorbide mononitrate.
Topics: Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1999 |
Isosorbide 5-mononitrate: a review of a sustained-release formulation (Imdur) in stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Delayed-Action Preparations; Drug Synergism; Humans; Isosorbide Dinitrate; Patient Compliance; Quality of Life | 1999 |
Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate.
Topics: Angina Pectoris; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1999 |
The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Endoscopy; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Ligation; Liver Transplantation; Lypressin; Middle Aged; Mineralocorticoid Receptor Antagonists; Nadolol; Nitric Oxide Donors; Nitroglycerin; Portasystemic Shunt, Transjugular Intrahepatic; Propranolol; Randomized Controlled Trials as Topic; Recurrence; Sclerotherapy; Spironolactone; Terlipressin; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
[Nitrates in cardiology practice].
Topics: Humans; Isosorbide Dinitrate; Molsidomine; Myocardial Ischemia; Nitroglycerin; Vasodilator Agents | 2000 |
Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. DUMQOL (DUtch Mononitrate Quality of Life) Study Group.
Topics: Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Quality of Life; Treatment Outcome; Vasodilator Agents | 2000 |
Primary prophylaxis of variceal bleeding.
Topics: Adrenergic beta-Antagonists; Cost-Benefit Analysis; Drug Therapy, Combination; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Markov Chains; Portasystemic Shunt, Transjugular Intrahepatic; Risk Factors; Sclerotherapy; Vasodilator Agents | 2003 |
Systolic hypertension in the elderly: pushing the frontiers of therapy--a suggested new approach.
Topics: Aged; Chronic Disease; Endothelium; Humans; Hypertension; Isosorbide Dinitrate; Nitric Oxide Donors; Systole; Vasodilator Agents | 2004 |
Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenergic alpha-Antagonists; Arteriosclerosis; Blood Pressure; Carbolines; Contraindications; Coronary Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Interactions; Endothelium, Vascular; Erectile Dysfunction; Heart Rate; Humans; Hypotension; Imidazoles; Isosorbide Dinitrate; Male; Molecular Structure; Myocardial Infarction; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation; Vasodilator Agents | 2004 |
[Nitrates. The place in contemporary therapy of ischemic heart disease].
Topics: Angina Pectoris; Contraindications; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Myocardial Infarction; Myocardial Ischemia; Nitrates; Nitroglycerin; Time Factors; Vasodilator Agents | 2005 |
The importance of circadian rhythms on drug response in hypertension and coronary heart disease--from mice and man.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Coronary Disease; Diuretics; Heart Rate; Humans; Hypertension; Isosorbide Dinitrate; Mice; Time Factors | 2006 |
Cirrhotic portal hypertension: current and future medical therapy for primary and secondary prevention of variceal bleeding.
Topics: Adrenergic beta-Antagonists; Animals; Contraindications; Drug Therapy, Combination; Endoscopy; Esophageal and Gastric Varices; Follow-Up Studies; Forecasting; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Middle Aged; Nadolol; Portasystemic Shunt, Surgical; Portasystemic Shunt, Transjugular Intrahepatic; Practice Guidelines as Topic; Propranolol; Randomized Controlled Trials as Topic; Rats; Risk Factors; Risk Reduction Behavior; Splanchnic Circulation; Stents; Time Factors; Vascular Resistance; Vasodilator Agents | 2006 |
[Nitrates in the practice of treatment of cardiovascular diseases].
Topics: Angina Pectoris; Cardiovascular Diseases; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 2006 |
Clinical use of nitric oxide donors and L-arginine in obstetrics.
Topics: Amniotic Fluid; Arginine; Biomarkers; Cervical Ripening; Female; Fetal Growth Retardation; Humans; Hypertension, Pregnancy-Induced; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Obstetric Labor, Premature; Pregnancy; Uterine Contraction; Version, Fetal | 2007 |
Review article: the modern management of portal hypertension--primary and secondary prophylaxis of variceal bleeding in cirrhotic patients.
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Esophageal and Gastric Varices; Humans; Hypertension, Portal; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Randomized Controlled Trials as Topic; Sclerotherapy; Secondary Prevention; Treatment Outcome | 2008 |
[Endothelium and nitric oxide].
Topics: Angiotensin-Converting Enzyme Inhibitors; Atherosclerosis; Endothelium, Vascular; Homeostasis; Humans; Hypolipidemic Agents; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Vasodilator Agents | 2008 |
[Beta-blockers plus isosorbide-5-mononitrate for prevention of esophageal variceal rebleeding: a systematic review].
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Esophageal and Gastric Varices; Humans; Isosorbide Dinitrate | 2008 |
[Recent findings on nitrates: their action, bioactivation and development of tolerance].
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Coronary Disease; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Oxidative Stress; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Vasodilation; Vasodilator Agents | 2008 |
Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate.
Topics: Animals; Drug Administration Schedule; Drug Tolerance; Heart Diseases; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Oxidative Stress; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Vasodilator Agents | 2009 |
Efficacy of beta-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding: a meta-analysis.
Topics: Adrenergic beta-Antagonists; Endoscopy; Esophageal and Gastric Varices; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Randomized Controlled Trials as Topic; Treatment Outcome; Vasodilator Agents | 2009 |
Outpatient induction -- how safe.
Topics: Ambulatory Care; Dinoprostone; Female; Germany; Humans; Infant, Newborn; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Oxytocics; Pregnancy; Safety | 2009 |
Systematic review: secondary prevention with band ligation, pharmacotherapy or combination therapy after bleeding from oesophageal varices.
Topics: Adrenergic beta-Antagonists; Combined Modality Therapy; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome; Vasodilator Agents | 2009 |
[Importance of drug treatment to lower portal pressure in the therapy of variceal bleeding].
Topics: Adrenergic beta-Antagonists; Anti-Bacterial Agents; Drug Therapy, Combination; Esophageal and Gastric Varices; Esophagoscopy; Gastrointestinal Hemorrhage; Hormones; Humans; Hypertension, Portal; Infection Control; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Lypressin; Portal Pressure; Secondary Prevention; Somatostatin; Terlipressin; Vasoconstrictor Agents; Vasodilator Agents | 2009 |
Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices.
Topics: Adrenergic beta-Antagonists; Esophageal and Gastric Varices; Esophagoscopy; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Randomized Controlled Trials as Topic; Statistics as Topic; Treatment Outcome; Vasodilator Agents | 2010 |
Endoscopic band ligation versus pharmacological therapy for variceal bleeding in cirrhosis: a meta-analysis.
Topics: Adrenergic beta-Antagonists; Comparative Effectiveness Research; Endoscopy; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Primary Prevention; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Treatment Outcome; Vasodilator Agents | 2011 |
Secondary prophylaxis of variceal bleeding for cirrhotic patients: a multiple-treatments meta-analysis.
Topics: Adrenergic beta-Antagonists; Combined Modality Therapy; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Laser Coagulation; Ligation; Liver Cirrhosis; Portasystemic Shunt, Transjugular Intrahepatic; Randomized Controlled Trials as Topic; Sclerotherapy; Secondary Prevention; Treatment Outcome; Vasodilator Agents | 2013 |
Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials.
Topics: Combined Modality Therapy; Databases, Bibliographic; Drug Therapy, Combination; Endpoint Determination; Esophageal and Gastric Varices; Follow-Up Studies; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Isosorbide Dinitrate; Nadolol; Propranolol; Randomized Controlled Trials as Topic; Risk; Spironolactone | 2014 |
Non-hormonal methods for induction of labour.
Topics: Acupuncture Therapy; Amnion; Breast; Castor Oil; Catheterization; Cervical Ripening; Coitus; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Oxytocics; Oxytocin; Pregnancy; Treatment Outcome; Vasodilator Agents | 2013 |
Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review.
Topics: Adrenergic beta-Antagonists; Animals; Chi-Square Distribution; Combined Modality Therapy; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hemostatic Techniques; Hemostatics; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Odds Ratio; Recurrence; Risk Factors; Treatment Outcome | 2014 |
Pharmacologic management of chronic stable angina.
Topics: Adrenergic beta-Antagonists; Angina, Stable; Benzazepines; Calcium Channel Blockers; Cardiovascular Agents; Humans; Isosorbide Dinitrate; Ivabradine; Nicorandil; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Vasodilator Agents | 2015 |
Cervical ripening before first trimester surgical evacuation for non-viable pregnancy.
Topics: Abortion, Eugenic; Abortion, Spontaneous; Adult; Cervical Ripening; Dilatation; Female; Humans; Isosorbide Dinitrate; Labor Stage, First; Misoprostol; Oxytocics; Pregnancy; Pregnancy Trimester, First; Randomized Controlled Trials as Topic | 2015 |
The Efficacy of Nitrates for Bone Health: A Systematic Review and Meta-Analysis of Observational and Randomized Controlled Studies.
Topics: Bone and Bones; Bone Density; Female; Fractures, Bone; Humans; Isosorbide Dinitrate; Male; Nitrates; Nitric Oxide Donors; Nitroglycerin; Risk Factors | 2022 |
Isosorbide mononitrate for cervical ripening during labour induction: A systematic review and meta-analysis of 23 randomized controlled trials.
Topics: Cervical Ripening; Female; Humans; Infant, Newborn; Isosorbide Dinitrate; Labor, Induced; Oxytocics; Pregnancy; Randomized Controlled Trials as Topic | 2022 |
353 trial(s) available for isosorbide dinitrate and isosorbide-5-mononitrate
| Article | Year |
|---|---|
Antianginal and anti-ischemic efficacy of nicorandil in comparison with isosorbide-5-mononitrate and isosorbide dinitrate: results from two multicenter, double-blind, randomized studies with stable coronary heart disease patients.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Exercise; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1992 |
Selected issues from an overview on nicorandil: tolerance, duration of action, and long-term efficacy.
Topics: Administration, Oral; Administration, Sublingual; Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Exercise; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin | 1992 |
Combined gallopamil and isosorbide-5-mononitrate in "mixed" angina pectoris.
Topics: Aged; Angina Pectoris; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Exercise; Female; Gallopamil; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia | 1992 |
[Lack of tolerance after administration of delayed-action isosorbide-5-mononitrate for 3 days in patients with exercise-induced silent ischemia: control with placebo].
Topics: Delayed-Action Preparations; Drug Tolerance; Exercise; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Vasodilator Agents | 1992 |
Influence of isosorbide-5-mononitrate on the circadian rhythm of angina pectoris.
Topics: Aged; Angina Pectoris; Circadian Rhythm; Coronary Disease; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male | 1992 |
[Pharmacokinetics of low-dose isosorbide dinitrate and metabolites after buccal or oral administration].
Topics: Administration, Buccal; Administration, Oral; Adult; Biological Availability; Blood Pressure; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male | 1992 |
[Biological availability and pharmacodynamics following single oral administration or three different sustained-release isosorbide-5-mononitrate dosage forms].
Topics: Adult; Biological Availability; Blood Pressure; Delayed-Action Preparations; Heart Rate; Humans; Isosorbide Dinitrate; Male | 1992 |
Absence of pre-dose rebound phenomena with once daily 5-ISMN in a controlled-release formulation.
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Exercise Test; Humans; Isosorbide Dinitrate; Middle Aged; Sweden; Time Factors; Vasodilator Agents | 1992 |
Effects of 8:00 a.m. and 2:00 p.m. doses of isosorbide-5-mononitrate during twice-daily therapy in stable angina pectoris.
Topics: Aged; Angina Pectoris; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Prospective Studies; Vasodilator Agents | 1992 |
Evaluation of bioavailability and pharmacokinetics of two isosorbide-5-mononitrate preparations in healthy volunteers.
Topics: Administration, Oral; Adult; Biological Availability; Humans; Isosorbide Dinitrate; Male; Therapeutic Equivalency; Vasodilator Agents | 1992 |
Comparison of anti-platelet properties of molsidomine, isosorbide-5-mononitrate and placebo in healthy volunteers.
Topics: Adult; Bleeding Time; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Male; Molsidomine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Reference Values; Thromboxane B2 | 1991 |
Hemodynamic, anti-ischemic, and neurohumoral effects of slow-release isosorbide-5-mononitrate in patients with coronary artery disease after short- and long-term therapy.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Coronary Disease; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Epinephrine; Heart Rate; Humans; Isosorbide Dinitrate; Middle Aged; Neurotransmitter Agents; Norepinephrine; Oxygen Consumption; Placebos; Renin; Time Factors; Vasopressins; Ventricular Function, Left | 1991 |
Efficacy of nifedipine and isosorbide mononitrate in combination with atenolol in stable angina.
Topics: Aged; Angina Pectoris; Atenolol; Blood Pressure; Double-Blind Method; Drug Combinations; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Nitroglycerin; Prospective Studies | 1991 |
Acute and chronic effects of once-daily isosorbide-5-mononitrate on the exercise capacity of patients with angina pectoris treated with a beta-blocking drug.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Endurance | 1991 |
[Randomized, double-blind comparison of isosorbide-5-mononitrate and delayed-action nifedipine in patients with stable exertional angina. Multicenter Study Group].
Topics: Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Costs; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Physical Exertion; Quality of Life | 1991 |
Evaluation of the antianginal and anti-ischemic efficacy of slow-release isosorbide-5-mononitrate capsules, bupranolol and their combination, in patients with chronic stable angina pectoris.
Topics: Aged; Angina Pectoris; Bupranolol; Chronic Disease; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1991 |
Isosorbide-5-mononitrate and atenolol in the treatment of stable exertional angina.
Topics: Aged; Angina Pectoris; Atenolol; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1991 |
Evaluation of the antianginal effect of isosorbide-5-mononitrate in patients with chronic stable angina pectoris.
Topics: Adult; Angina Pectoris; Blood Pressure; Chronic Disease; Double-Blind Method; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1991 |
Treatment of angina pectoris with isosorbide-5-mononitrate. A multicenter study in general practice.
Topics: Aged; Angina Pectoris; Chronic Disease; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1991 |
Sustained-release IS-5-MN in the treatment of coronary heart disease.
Topics: Angina Pectoris; Chronic Disease; Coronary Disease; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Male; Monitoring, Physiologic | 1991 |
[Thrombocyte aggregation and fibrinolysis in healthy probands treated with molsidomine, isosorbide-5-mononitrate and placebo].
Topics: Adult; Fibrinolysis; Humans; Isosorbide Dinitrate; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Tissue Plasminogen Activator | 1991 |
A combined single and multiple dose pharmacokinetic study of oral isosorbide-5-mononitrate in healthy volunteers.
Topics: Administration, Oral; Adult; Biological Availability; Chemistry, Pharmaceutical; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Male; Tablets | 1991 |
Chronotherapy in coronary heart disease: comparison of two nitrate treatments.
Topics: Aged; Circadian Rhythm; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Exercise; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1991 |
Comparative evaluation of the effect of afterload- and preload-reducing drugs on diastolic cardiac function in hypertensive patients.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cilazapril; Double-Blind Method; Gated Blood-Pool Imaging; Humans; Hydrochlorothiazide; Hypertension; Isosorbide Dinitrate; Myocardial Contraction; Pyridazines; Ventricular Function, Left | 1991 |
[A new anti-ischemic drug for the treatment of stable effort angina pectoris: nicorandil. Comparison with placebo and isosorbide-5-mononitrate].
Topics: Aged; Angina Pectoris; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Placebos; Vasodilator Agents | 1991 |
Comparison of the effect of isosorbide-5-mononitrate and isosorbide dinitrate in a slow-release form on exercise-induced myocardial ischemia.
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1991 |
[Nitrate tolerance measured by exercise test. Comparison of 2 preparations].
Topics: Aged; Angina Pectoris; Drug Tolerance; Exercise Test; Humans; Isosorbide Dinitrate; Middle Aged; Nitroglycerin | 1991 |
Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis. A randomized controlled study.
Topics: Aged; Drug Therapy, Combination; Female; Hemodynamics; Hepatic Veins; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver; Liver Circulation; Liver Cirrhosis; Male; Middle Aged; Propranolol; Venous Pressure | 1991 |
Controlled release isosorbide-5-mononitrate in angina pectoris: a comparison with standard formulation isosorbide dinitrate.
Topics: Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate | 1991 |
Circadian variation of cardiac performance in coronary heart disease.
Topics: Aged; Circadian Rhythm; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Humans; Isosorbide Dinitrate; Male; Middle Aged; Pulmonary Wedge Pressure | 1990 |
Pulmonary arterial pressure and working capacity as parameters for checking the development of tolerance under nitrate therapy.
Topics: Administration, Oral; Adult; Coronary Disease; Electrocardiography; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Pulmonary Wedge Pressure; Reproducibility of Results | 1990 |
[Changes in exercise capacity and in induced ischemia with an oral dose of 5 isosorbide mononitrate in patients with stable angina pectoris].
Topics: Administration, Oral; Aged; Angina Pectoris; Coronary Disease; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Endurance; Single-Blind Method | 1990 |
Long-term haemodynamic effects of isosorbide 5-mononitrate in patients with cirrhosis and portal hypertension.
Topics: Administration, Oral; Aged; Blood Pressure; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver; Liver Cirrhosis; Male; Middle Aged; Nitroglycerin; Placebos; Time Factors | 1990 |
The effects of oral isosorbide 5-mononitrate on mortality following acute myocardial infarction: a multicentre study.
Topics: Analysis of Variance; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Male; Multicenter Studies as Topic; Myocardial Infarction; Placebos; Randomized Controlled Trials as Topic | 1990 |
Comparison of the effects of a controlled-release formulation of isosorbide-5-mononitrate and conventional isosorbide dinitrate on exercise performance in men with stable angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Exercise; Humans; Isosorbide Dinitrate; Male; Middle Aged; Randomized Controlled Trials as Topic; Time Factors | 1990 |
Efficacy of isosorbide-5-mononitrate on painful and silent myocardial ischemia after myocardial infarction.
Topics: Adult; Aged; Angina Pectoris; Drug Administration Schedule; Electrocardiography, Ambulatory; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Randomized Controlled Trials as Topic; Single-Blind Method | 1990 |
Intravenous isosorbide-5-mononitrate in the treatment of acute myocardial infarction.
Topics: Clinical Trials as Topic; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Time Factors | 1990 |
Long-acting, marked antiischemic effect maintained unattenuated during long-term interval treatment with once-daily isosorbide-5-mononitrate in sustained-release form.
Topics: Blood Pressure; Coronary Disease; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Isosorbide Dinitrate; Physical Exertion; Randomized Controlled Trials as Topic; Time Factors | 1990 |
[A new antianginal preparation: isosorbide-5-mononitrate].
Topics: Angina Pectoris; Chromatography, Gas; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Time Factors | 1990 |
Inhibition of platelet function during in vivo infusion of isosorbide mononitrates: relationship between plasma drug concentration and hemodynamic effects.
Topics: Coronary Disease; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1990 |
N-acetylcysteine modifies the acute effects of isosorbide-5-mononitrate in angina pectoris patients evaluated by exercise testing.
Topics: Acetylcysteine; Administration, Sublingual; Adult; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Random Allocation | 1989 |
Efficacy of controlled-release isosorbide-5-mononitrate as adjunctive treatment to beta-blocking agents in patients with stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1989 |
Lack of effect of asymmetrical dosage timing of isosorbide-5-mononitrate on nitrate tolerance during long-term administration.
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Patient Compliance; Random Allocation | 1989 |
A randomised double-blind crossover study of isosorbide mononitrate and nifedipine retard in chronic stable angina.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nifedipine; Nitroglycerin; Random Allocation; Vasodilator Agents | 1989 |
Effects of diltiazem and isosorbide-5-mononitrate, alone and in combination, on patients with stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise Test; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Middle Aged; Nitroglycerin; Random Allocation; Rest | 1989 |
In vivo actions of organic nitrates on platelet function in humans.
Topics: Dose-Response Relationship, Drug; Epoprostenol; Humans; Isosorbide Dinitrate; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Vasodilator Agents | 1989 |
[Lack of tolerance development in interval therapy with 50 mg isosorbide-5-nitrate retard (Elantan long)].
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Exercise Test; Heart Rate; Humans; Isosorbide Dinitrate; Long-Term Care; Male; Middle Aged; Pulmonary Wedge Pressure; Vasodilator Agents | 1989 |
[Bioavailability of sustained-release and nonsustained-release isosorbide-5-mononitrate].
Topics: Biological Availability; Capsules; Delayed-Action Preparations; Half-Life; Humans; Isosorbide Dinitrate; Tablets | 1989 |
[Efficacy and length of action of a slow-release formulation of isosorbide-5-mononitrate in stable effort angina].
Topics: Adult; Aged; Angina Pectoris; Child; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Middle Aged; Random Allocation; Time Factors | 1989 |
[Effects of slow-release isosorbide-5-mononitrate on ergometric parameters and cardiac output in stable effort angina pectoris: a double-blind randomized placebo study].
Topics: Adult; Aged; Angina Pectoris; Cardiac Output; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Placebos; Randomized Controlled Trials as Topic | 1989 |
[Combination therapy with slow release isosorbide nitrate and diltiazem in silent myocardial ischemia].
Topics: Adult; Coronary Disease; Diltiazem; Drug Therapy, Combination; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Randomized Controlled Trials as Topic; Vasodilator Agents | 1989 |
[Pharmacokinetic profile and bioavailability of a new pharmaceutical formulation of isosorbide-5-mononitrate sustained-release formulation].
Topics: Adult; Biological Availability; Delayed-Action Preparations; Half-Life; Humans; Isosorbide Dinitrate; Male; Therapeutic Equivalency | 1989 |
Lack of effects of isosorbide-5-mononitrate on hepatic hemodynamics in HBsAg-positive cirrhosis.
Topics: Aged; Blood Pressure; Drug Administration Schedule; Hemodynamics; Hepatitis B Surface Antigens; Humans; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Male; Middle Aged; Portal Vein; Random Allocation | 1989 |
Sustained effect of and lack of development of tolerance to controlled-release isosorbide-5-mononitrate in chronic stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation; Vasodilator Agents | 1989 |
Long term efficacy of a controlled-release formulation of isosorbide 5-mononitrate (Imdur) in angina patients receiving beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1987 |
Mononitrates in combination with beta-blocker therapy in the treatment of severe angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Random Allocation | 1987 |
Anti-anginal efficacy of a controlled-release formulation of isosorbide-5-mononitrate once daily in angina patients on chronic beta-blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Random Allocation | 1988 |
Reduction of portal pressure by isosorbide-5-mononitrate in patients with cirrhosis. Effects on splanchnic and systemic hemodynamics and liver function.
Topics: Adult; Aged; Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver; Liver Cirrhosis; Male; Middle Aged; Splanchnic Circulation | 1989 |
[Effects of oral administration of subcontinuous doses of delayed-action isosorbide-5-mononitrate. Absence of tolerance].
Topics: Administration, Oral; Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1988 |
Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Exercise Test; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin | 1986 |
Antianginal efficacy and tolerability of 50 mg sustained-release isosorbide 5-mononitrate in an open twelve-month observation study.
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin | 1987 |
Controlled study of the haemodynamic effects of isosorbide 5-mononitrate in acute myocardial infarction.
Topics: Acute Disease; Administration, Oral; Aged; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitroglycerin | 1987 |
Anti-ischemic effects of slow-release formulations of nifedipine, isosorbide-5-mononitrate and their combination in patients with coronary heart disease.
Topics: Coronary Disease; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Random Allocation | 1988 |
Nitrates and calcium antagonists for silent myocardial ischemia.
Topics: Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Monitoring, Physiologic; Nifedipine; Random Allocation | 1988 |
An evaluation of the effects of isosorbide 5-mononitrate in patients with angina on effort using dynamic electrocardiography and echocardiography.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Echocardiography; Electrocardiography; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Monitoring, Physiologic; Physical Exertion | 1987 |
Dose-effect relationship amongst three different sustained-release forms of isosorbide 5-mononitrate in patients with coronary artery disease.
Topics: Aged; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1987 |
Influence of isosorbide 5-mononitrate 20 mg, sustained-release 50 mg and sustained-release nifedipine 20 mg on ischaemic ST-segment changes during Holter monitoring. A double-blind cross-over study in patients with spontaneous angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Humans; Isosorbide Dinitrate; Monitoring, Physiologic; Nifedipine | 1987 |
Medical treatment of patients with severe exertional and rest angina: double blind comparison of beta blocker, calcium antagonist, and nitrate.
Topics: Aged; Angina Pectoris; Atenolol; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Random Allocation | 1987 |
Isosorbide-5-mononitrate and isosorbide dinitrate retard in the treatment of coronary heart disease: a multi-centre study.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1987 |
Acute effect of various doses of isosorbide-5-mononitrate on hemodynamic and exercise performance in coronary artery disease.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Physical Exertion | 1988 |
Isosorbide-5-mononitrate and nifedipine can reduce ischaemic ST-segment changes during Holter monitoring in patients with spontaneous angina pectoris.
Topics: Activities of Daily Living; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Monitoring, Physiologic; Nifedipine; Random Allocation | 1988 |
[The effect of time and dosage of isosorbide mononitrate on objective and subjective parameters in angina pectoris].
Topics: Aged; Angina Pectoris; Circadian Rhythm; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Quality of Life | 1988 |
[Delayed-action isosorbide-5-mononitrate preparations--are there differences in the acute effect?].
Topics: Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1987 |
[Dose-dependent serum concentration of ISDN and its metabolites following administration of ISDN-retard. Studies under steady-state conditions].
Topics: Aged; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Random Allocation | 1986 |
The effect of isosorbide-5-mononitrate (5-ISMN) Durules on exercise tolerance in patients with exertional angina pectoris. A placebo controlled study.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion; Placebos; Random Allocation | 1986 |
[Anti-angina action and tolerance of isosorbide-5-mononitrate or nifedipine in retard form].
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Exercise Test; Humans; Isosorbide Dinitrate; Nifedipine; Random Allocation | 1986 |
The therapeutic role of isosorbide-5-mononitrate+ in stable and unstable angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate | 1986 |
[Intraindividual dose-response relationship of sustained-release Elantan].
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1986 |
Enhanced platelet sensitivity to prostacyclin after isosorbide-5-mononitrate in patients with stable angina pectoris.
Topics: Adult; Angina Pectoris; Blood Platelets; Epoprostenol; Female; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1986 |
[Bioavailability of delayed-action and non-delayed-action preparations of isosorbide-5-nitrate].
Topics: Adult; Biological Availability; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Random Allocation | 1987 |
Isosorbide-5-mononitrate in angina pectoris: plasma concentrations and duration of effects after acute therapy.
Topics: Administration, Oral; Aged; Angina Pectoris; Blood Pressure; Double-Blind Method; Drug Evaluation; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1987 |
A comparison of intravenous elantan and frusemide in patients with chronic cardiac failure.
Topics: Blood Pressure; Cardiac Output; Chronic Disease; Coronary Circulation; Furosemide; Heart Failure; Humans; Injections, Intravenous; Isosorbide Dinitrate | 1987 |
Calcium channel blocker and isosorbide 5-mononitrate in the management of chronic cardiac failure.
Topics: Chronic Disease; Coronary Disease; Drug Therapy, Combination; Exercise Test; Felodipine; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Nitrendipine | 1987 |
Experience of long term treatment and different dosage regimens of isosorbide 5-mononitrate.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1987 |
Usefulness of twice-daily isosorbide-5-mononitrate in preventing development of tolerance in angina pectoris.
Topics: Aged; Angina Pectoris; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion; Random Allocation; Time Factors | 1987 |
Hemodynamic effects of oral isosorbide-5-mononitrate and dinitrate in ischemic heart failure.
Topics: Administration, Oral; Adult; Aged; Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1987 |
Acute and sustained effects of isosorbide 5-mononitrate in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1986 |
Duration of effects and tolerance of slow-release isosorbide-5-mononitrate for angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Electrocardiography; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Random Allocation | 1987 |
[Bioavailability of isosorbide dinitrate and isosorbide-5-mononitrate under steady-state conditions].
Topics: Adult; Biological Availability; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Random Allocation | 1985 |
[4 different nitrate preparations with regard to the possible development of tolerance in long-term treatment].
Topics: Administration, Oral; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Delayed-Action Preparations; Drug Tolerance; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Long-Term Care; Male; Middle Aged; Myocardial Contraction; Nitroglycerin | 1985 |
Randomized crossover trial of isosorbide mononitrate (Elantan 20) and slow-release glyceryl trinitrate in the treatment of angina pectoris.
Topics: Administration, Oral; Aged; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Physical Exertion; Random Allocation; Time Factors | 1985 |
[Efficacy and duration of action of isosorbide-5-mononitrate in the treatment of stable angina of effort. Comparison with sustained-release isosorbide dinitrate].
Topics: Adult; Angina Pectoris; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1985 |
Pharmacokinetics and bioavailability of isosorbide-5-mononitrate in humans.
Topics: Adult; Biological Availability; Double-Blind Method; Half-Life; Humans; Isosorbide Dinitrate; Kinetics; Male; Random Allocation | 1985 |
Efficacy of isosorbide-5-mononitrate in the prevention of myocardial ischemia induced by ergonovine and by hand-grip tests.
Topics: Aged; Coronary Disease; Echocardiography; Electrocardiography; Ergonovine; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1985 |
[Coronary therapeutic effectiveness of low-dose IS-5-MN in comparison with the combination IS-5-MH and metipranolol and placebo].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Metipranolol; Middle Aged; Propanolamines | 1983 |
Is isosorbide mononitrate better than the dinitrate?
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Humans; Isosorbide Dinitrate | 1984 |
[Treatment of coronary disease with elantan. Results of a multicenter study].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1984 |
[Prevention of the development of tolerance to isosorbide dinitrate in interval therapy].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Heart Rate; Humans; Isosorbide Dinitrate | 1984 |
[Long-term tolerance and therapeutic coronary effect of isosorbide-5-mononitrate. Open multicenter study of ISMO 20].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Drug Tolerance; Female; Humans; Isosorbide Dinitrate; Long-Term Care; Male; Middle Aged | 1983 |
Intra-individual comparison of the action of equal doses of isosorbide-5-endomononitrate, slow-release isosorbide dinitrate and placebo in patients with coronary heart disease.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitroglycerin | 1983 |
[Randomized double-blind comparative study: glycerol trinitrate and isosorbide mononitrate].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin | 1983 |
[Nitrate tolerance: pro and con].
Topics: Angina Pectoris; Cardiac Output; Clinical Trials as Topic; Drug Administration Schedule; Drug Tolerance; Headache; Heart Rate; Humans; Hypertension; Isosorbide Dinitrate; Long-Term Care; Nitrates; Nitroglycerin | 1984 |
Treatment of coronary heart disease with isosorbide mononitrate ('Elantan' 20).
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin | 1984 |
Differences in the production of methemoglobin during high-dose treatment with isosorbide dinitrate or isosorbide 5-mononitrate.
Topics: Adult; Coronary Disease; Humans; Isosorbide Dinitrate; Methemoglobin; Time Factors | 1984 |
[Results of a clinical multicenter study with Mono Mack 20 mg/40 mg].
Topics: Adult; Aged; Angina Pectoris; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1983 |
Comparative hemodynamic study of IS-5-MN and ISDN in man--which are equieffective doses?
Topics: Adult; Aged; Blood Pressure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged | 1983 |
[Long-term tolerance and effect of isosorbide-5-mononitrate in comparison to isosorbide dinitrate (ISDN retard) in patients with coronary disease].
Topics: Adult; Aged; Coronary Disease; Delayed-Action Preparations; Female; Hemodynamics; Humans; Isosorbide; Isosorbide Dinitrate; Long-Term Care; Male; Middle Aged | 1981 |
[Hemodynamic effect of 20 mg and 50 mg of 5-isosorbide mononitrate in acute and chronic therapy].
Topics: Coronary Disease; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Long-Term Care; Male; Middle Aged | 1982 |
[5-isosorbide mononitrate at rest and on exercise in coronary heart disease: acute and long-term effect].
Topics: Adult; Blood Pressure; Cardiac Output; Coronary Disease; Drug Tolerance; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion; Pulmonary Artery; Time Factors | 1982 |
[Steady state kinetics of isosorbide-5-mononitrate in patients with coronary disease].
Topics: Adult; Aged; Coronary Disease; Female; Humans; Isosorbide; Isosorbide Dinitrate; Kinetics; Male; Middle Aged | 1981 |
[Comparison of the anti-angina effect and effect duration of isosorbide dinitrate, isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN)].
Topics: Angina Pectoris; Delayed-Action Preparations; Hemodynamics; Humans; Isosorbide Dinitrate; Male | 1981 |
[Effect of isosorbide-5-mononitrate (IS-5-MN) on left ventricular hemodynamics].
Topics: Adult; Coronary Disease; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged | 1981 |
[The effect of IS-5-MN in coronary disease. Monocentric double-blind crossover comparison with ISDN retard and placebo].
Topics: Aged; Coronary Disease; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Isosorbide; Isosorbide Dinitrate; Male; Middle Aged; Sorbitol | 1981 |
First data on effects and pharmacokinetics of isosorbide-5-mononitrate in normal man.
Topics: Adult; Humans; Isosorbide Dinitrate; Kinetics; Male; Plethysmography | 1981 |
Failure of "effective" treatment for heart failure to improve normal customary activity.
Topics: Activities of Daily Living; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Chronic Disease; Deoxyepinephrine; Dopamine Agonists; Exercise Test; Exercise Tolerance; Female; Heart Failure; Humans; Indoles; Isosorbide Dinitrate; Male; Middle Aged; Single-Blind Method; Treatment Failure; Vasodilator Agents | 1995 |
Differences in ischemic threshold and nitrate efficacy between normotensive and hypertensive patients with stable angina pectoris.
Topics: Aged; Angina Pectoris; Antihypertensive Agents; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1995 |
Antianginal effect of transdermal nitroglycerin and oral nitrates given for 24 hours a day in 2,456 patients with stable angina pectoris. The Italian Multicenter Study.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Angina Pectoris; Chronic Disease; Circadian Rhythm; Drug Tolerance; Female; Humans; Isosorbide Dinitrate; Italy; Male; Middle Aged; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilator Agents | 1995 |
[Isosorbide-5-mononitrate in silent ischemia].
Topics: Adult; Aged; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Conduction System; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Vasodilator Agents | 1995 |
Long-term effect of nadolol or nadolol plus isosorbide-5-mononitrate on renal function and ascites formation in patients with cirrhosis. GTIP Gruppo Triveneto per l'Ipertensione Portale.
Topics: Adolescent; Adult; Aged; Ascites; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Humans; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Longitudinal Studies; Male; Middle Aged; Nadolol; Venous Pressure | 1995 |
ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative
Topics: Administration, Oral; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Delayed-Action Preparations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Magnesium Sulfate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Vasodilator Agents | 1995 |
Duplex Doppler ultrasonography allows a multiorgan noninvasive approach to splanchnic pharmacodynamics in patients with cirrhosis.
Topics: Administration, Oral; Adult; Aged; Blood Flow Velocity; Blood Pressure; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Kidney; Liver; Liver Cirrhosis; Male; Mesenteric Artery, Superior; Middle Aged; Nadolol; Pulsatile Flow; Splanchnic Circulation; Ultrasonography, Doppler, Color; Vascular Resistance; Vasodilator Agents | 1995 |
Evaluation of the pharmacokinetics and absolute bioavailability of three isosorbide-5-mononitrate preparations in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Humans; Injections, Intravenous; Isosorbide Dinitrate; Vasodilator Agents | 1995 |
[Comparison of the effectiveness of olicard 40 retard and cardonit 40 prolongatum preparations in treatment of stable coronary heart disease].
Topics: Adult; Coronary Disease; Delayed-Action Preparations; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Treatment Outcome; Vasodilator Agents | 1994 |
Nitrates in myocardial infarction: influence on infarct size, reperfusion, and ventricular remodelling.
Topics: Aged; Delayed-Action Preparations; Double-Blind Method; Echocardiography; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Middle Aged; Myocardial Infarction; Vasodilator Agents; Ventricular Function, Left | 1995 |
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis.
Topics: Cyclic GMP; Disease Progression; Endothelins; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Humans; Hypertension, Renal; Isosorbide Dinitrate; Nitric Oxide; Pilot Projects; Vasodilator Agents | 1995 |
Reduction of exercise-induced myocardial perfusion defects by isosorbide-5-nitrate: assessment using quantitative Tc-99m-MIBI-SPECT.
Topics: Adult; Aged; Coronary Circulation; Double-Blind Method; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon | 1995 |
Short and long-acting oral nitrates for stable angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Drug Therapy, Combination; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; United States; United States Food and Drug Administration; Vasodilator Agents | 1994 |
Duplex Doppler sonographic evaluation of splanchnic and renal effects of single agent and combined therapy with nadolol and isosorbide-5-mononitrate in cirrhotic patients.
Topics: Adult; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Nadolol; Renal Circulation; Splanchnic Circulation; Ultrasonography, Doppler, Duplex; Vasodilator Agents | 1994 |
[Prolonged treatment with isosorbide-5-mononitrate in patients with silent ischemia].
Topics: Adult; Aged; Double-Blind Method; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Time Factors; Vasodilator Agents | 1995 |
Portal and systemic haemodynamic response to acute and chronic administration of low and high dose isosorbide-5-mononitrate in patients with cirrhosis.
Topics: Adult; Aged; Azygos Vein; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Schedule; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Male; Middle Aged; Patient Compliance; Regional Blood Flow; Stimulation, Chemical; Vasodilator Agents | 1995 |
[Hemodynamics effects of continuous infusion of molsidomine and nitrates and subsequent oral medication in therapy of acute myocardial infarct].
Topics: Administration, Oral; Aged; Aged, 80 and over; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Myocardial Infarction; Nitrates; Nitroglycerin; Vasodilator Agents | 1994 |
Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Exercise Test; Felodipine; Female; Humans; Isosorbide Dinitrate; Male; Myocardial Ischemia; Prospective Studies; Treatment Outcome; Vasodilator Agents | 1994 |
Propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis: long-term hemodynamic and renal effects.
Topics: Aldosterone; Analysis of Variance; Body Water; Chi-Square Distribution; Dinoprostone; Drug Therapy, Combination; Female; Follow-Up Studies; Hemodynamics; Humans; Hypertension, Portal; Inulin; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Male; Middle Aged; Portal Pressure; Propranolol; Renin; Splanchnic Circulation; Vasodilator Agents | 1994 |
Oral isosorbide-5-mononitrate reduces the rebleeding rate during the course of injection sclerotherapy for esophageal varices.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Male; Middle Aged; Recurrence; Sclerotherapy | 1994 |
Randomized controlled trial of oral captopril, of oral isosorbide mononitrate and of intravenous magnesium sulphate started early in acute myocardial infarction: safety and haemodynamic effects. ISIS-4 (Fourth International Study of Infarct Survival) Pilo
Topics: Captopril; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Magnesium Sulfate; Male; Middle Aged; Myocardial Infarction; Patient Compliance; Pilot Projects; Research Design; Safety; Time Factors; Vasodilator Agents | 1994 |
[Hypotensive effects of mononitrates (IS-5-MN) in light of 24-hour blood pressure monitoring].
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Monitoring, Physiologic; Vasodilator Agents | 1994 |
[Isosorbide-5-mononitrate in angina pectoris: its efficacy and absence of tolerance and rebound with an eccentric type of administration].
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Angina Pectoris; Canada; Drug Tolerance; Exercise Test; Female; Humans; Isosorbide Dinitrate; Israel; Male; Middle Aged; Survival Analysis; Time Factors; United Kingdom; United States; Vasodilator Agents | 1994 |
Lack of pharmacologic tolerance and rebound angina pectoris during twice-daily therapy with isosorbide-5-mononitrate.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion; Single-Blind Method; Time Factors; Vasodilator Agents | 1994 |
Duplex Doppler ultrasonographic comparison of the effects of propranolol and isosorbide-5-mononitrate on portal hemodynamics.
Topics: Delayed-Action Preparations; Double-Blind Method; Drug Monitoring; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propranolol; Splanchnic Circulation; Ultrasonography | 1993 |
Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. A randomized, double-blind, cross-over study. The Swedish Multicentre Group.
Topics: Analysis of Variance; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Vasodilator Agents | 1994 |
Eccentric dosing with isosorbide-5-mononitrate in angina pectoris.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Placebos; Tablets; Time Factors; Vasodilator Agents | 1993 |
Bioavailability and pharmacokinetics of a new isosorbide dinitrate spray preparation in healthy volunteers.
Topics: Adolescent; Adult; Aerosols; Biological Availability; Chromatography, Gas; Humans; Isosorbide Dinitrate; Male; Therapeutic Equivalency | 1993 |
Efficacy and safety of extended-release isosorbide mononitrate for stable effort angina pectoris.
Topics: Adult; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Single-Blind Method; Vasodilator Agents | 1993 |
Efficacy of isosorbide-5-mononitrate versus nifedipine in preventing spontaneous and ergonovine-induced myocardial ischaemia. A double-blind, placebo-controlled study.
Topics: Administration, Oral; Adult; Angina Pectoris, Variant; Double-Blind Method; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Ergonovine; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nifedipine; Vasodilator Agents | 1993 |
Effects of an oral dose of isosorbide dinitrate on platelet function and fibrinolysis in healthy volunteers.
Topics: Administration, Oral; Adult; beta-Thromboglobulin; Blood Platelets; Blood Pressure; Double-Blind Method; Epinephrine; Fibrinolysis; Heart Rate; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Platelet Aggregation; Vasodilation | 1993 |
Isosorbide-5-mononitrate versus propranolol in the prevention of first bleeding in cirrhosis.
Topics: Aged; Digestive System; Endoscopy; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Patient Dropouts; Personnel Selection; Propranolol; Prospective Studies | 1993 |
Hemodynamic effects of captopril and isosorbide mononitrate started early in acute myocardial infarction: a randomized placebo-controlled study.
Topics: Aged; Captopril; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Isosorbide; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Pilot Projects | 1993 |
[Clinical evaluation of the changes produced by nitrates in patients with chronic heart insufficiency].
Topics: Adult; Aged; Chronic Disease; Double-Blind Method; Echocardiography; Exercise Test; Female; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1993 |
[Acute effects of isosorbide mononitrate on blood circulation and myocardial ischemia in patients with coronary atherosclerosis].
Topics: Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Cineangiography; Coronary Artery Disease; Female; Hemodynamics; Humans; Injections, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Vasodilator Agents; Ventricular Function, Left | 1995 |
Effect of isosorbide-5-mononitrate on plasma and urine levels of cyclic GMP in relation to exercise in coronary patients compared with control subjects.
Topics: Angina Pectoris; Coronary Disease; Cyclic GMP; Exercise; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1995 |
Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding.
Topics: Actuarial Analysis; Adrenergic beta-Antagonists; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nadolol; Recurrence; Sclerotherapy; Survival Analysis; Treatment Outcome; Vasodilator Agents | 1996 |
A comparison of nifedipine once daily (Adalat LA), isosorbide mononitrate once daily, and isosorbide dinitrate twice daily in patients with chronic stable angina.
Topics: Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Treatment Outcome; Vasodilator Agents | 1996 |
Nitrate-induced headache in patients with stable angina pectoris: beneficial effect of starting on a low dosage. 5-ISMN headache study group.
Topics: Adult; Aged; Angina Pectoris; Cross-Over Studies; Double-Blind Method; Female; Headache; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1996 |
[Intracoronary isosorbide mononitrate versus placebo. A double-blind study with quantitative coronary angiography].
Topics: Adult; Aged; Blood Pressure; Coronary Angiography; Coronary Vessels; Double-Blind Method; Female; Humans; Injections, Intra-Arterial; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1995 |
Effects of isosorbide-5-mononitrate on variceal pressure and systemic and splanchnic haemodynamics in patients with cirrhosis.
Topics: Aged; Blood Pressure; Double-Blind Method; Esophageal and Gastric Varices; Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Male; Middle Aged; Splanchnic Circulation; Vasodilator Agents; Venous Pressure | 1996 |
Differing actions of the acute administration of propranolol and isosorbide-5-mononitrate on the portal circulation.
Topics: Blood Pressure; Female; Heart Rate; Humans; Isosorbide Dinitrate; Liver Circulation; Male; Portal Vein; Portasystemic Shunt, Transjugular Intrahepatic; Propranolol; Regional Blood Flow; Splanchnic Nerves; Treatment Outcome; Vasodilator Agents | 1996 |
Counterregulatory responses: sustained-release isosorbide-5-mononitrate versus transdermal nitroglycerin.
Topics: Administration, Cutaneous; Adult; Blood Pressure; Body Weight; Catecholamines; Delayed-Action Preparations; Drug Tolerance; Heart Rate; Hematocrit; Humans; Isosorbide Dinitrate; Male; Nitroglycerin; Renin; Single-Blind Method; Sodium; Vasodilator Agents | 1996 |
Effects of antianginal therapy with a calcium antagonist and nitrates on dobutamine-atropine stress echocardiography. Comparison with exercise electrocardiography.
Topics: Atropine; Calcium Channel Blockers; Cardiotonic Agents; Coronary Disease; Diltiazem; Dobutamine; Dose-Response Relationship, Drug; Echocardiography; Electrocardiography; Exercise Test; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Nitrates; Parasympatholytics; Prospective Studies; Vasodilator Agents | 1997 |
[The therapeutic and prophylactic use of Olicard-Retard under outpatient polyclinical conditions in stenocardia patients].
Topics: Aged; Ambulatory Care; Angina Pectoris; Chronic Disease; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Middle Aged; Vasodilator Agents | 1997 |
Hemodynamic evaluation of the addition of isosorbide-5-mononitrate to nadolol in cirrhotic patients with insufficient response to the beta-blocker alone.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Female; Heart Rate; Hemodynamics; Hepatic Artery; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver; Liver Cirrhosis; Male; Middle Aged; Nadolol; Vasodilator Agents | 1997 |
[Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation].
Topics: Adult; Biological Availability; Cross-Over Studies; Female; Humans; Isosorbide Dinitrate; Male; Tablets; Therapeutic Equivalency; Vasodilator Agents | 1997 |
Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Intravaginal; Adult; Alprostadil; Cervix Uteri; Female; Humans; Isosorbide Dinitrate; Nitric Oxide; Pregnancy; Pregnancy Trimester, First; Prospective Studies | 1997 |
Comparison of multiple-dose and once-daily nitrate therapy in 1212 patients with stable angina pectoris: effects on quality of life indices. Dutch Mononitrate Quality of Life (DUMQOL) Study Group.
Topics: Activities of Daily Living; Administration, Sublingual; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina Pectoris; Calcium Channel Blockers; Drug Administration Schedule; Exercise Tolerance; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Netherlands; Patient Compliance; Quality of Life; Reproducibility of Results; Stress, Psychological; Tablets; Vasodilator Agents | 1997 |
Effects of isosorbide-5-mononitrate compared with propranolol on first bleeding and long-term survival in cirrhosis.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propranolol; Single-Blind Method; Vasodilator Agents | 1997 |
Endoscopic assessment of variceal volume and wall tension in cirrhotic patients: effects of pharmacological therapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Double-Blind Method; Endosonography; Esophageal and Gastric Varices; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propranolol; Vasodilator Agents | 1997 |
Beta-adrenergic blockers and nitrovasodilators for the treatment of portal hypertension: the good, the bad, the ugly.
Topics: Adrenergic beta-Antagonists; Humans; Hypertension, Portal; Isosorbide Dinitrate; Propranolol; Vasodilator Agents | 1997 |
Influence of diet on the single-dose pharmacokinetics of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate.
Topics: Administration, Oral; Adult; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Diet, Fat-Restricted; Dietary Fats; Food-Drug Interactions; Humans; Intestinal Absorption; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1997 |
Effect of extended-release isosorbide mononitrate one hour after dosing in patients with stable angina pectoris. IMDUR Study Group.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1997 |
[Efficacy of mononitrate retard therapy in patients with advanced congestive heart failure].
Topics: Aged; Echocardiography; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Failure; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1997 |
Infusions with molsidomine and isosorbide-5-mononitrate in congestive heart failure: mechanisms underlying attenuation of effects.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Double-Blind Method; Drug Tolerance; Female; Fluid Shifts; Heart Atria; Heart Failure; Heart Rate; Hematocrit; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Neurotransmitter Agents; Pulmonary Artery; Renin; Time Factors; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 1998 |
Effects on heart rate variability of isosorbide-5-mononitrate and metoprolol in patients with recent onset of angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina Pectoris; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Vasodilator Agents | 1998 |
Doppler sonography and hepatic vein catheterization in portal hypertension: assessment of agreement in evaluating severity and response to treatment.
Topics: Adrenergic beta-Antagonists; Catheterization, Peripheral; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Hepatic Veins; Humans; Hypertension, Portal; Isosorbide Dinitrate; Linear Models; Liver Cirrhosis; Male; Middle Aged; Nadolol; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vasodilator Agents | 1998 |
Propranolol plus prazosin compared with propranolol plus isosorbide-5-mononitrate in the treatment of portal hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatic Veins; Humans; Hypertension, Portal; Isosorbide Dinitrate; Male; Middle Aged; Prazosin; Propranolol; Vasodilator Agents; Venous Pressure | 1998 |
Duplex-Doppler evaluation of the effects of propranolol and isosorbide-5-mononitrate on portal flow and splanchnic arterial circulation in cirrhosis.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Esophageal and Gastric Varices; Female; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Portal System; Propranolol; Splanchnic Circulation; Ultrasonography, Doppler, Duplex; Vasodilator Agents | 1998 |
Single and multiple dose pharmacokinetic studies of oral sustained release and non-sustained release formulations of isosorbide-5-mononitrate in healthy volunteers.
Topics: Adult; Area Under Curve; Chromatography, Gas; Cross-Over Studies; Delayed-Action Preparations; Electrochemistry; Half-Life; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 1998 |
[Actions of pentaerithritol tetranitrate, isosorbide mononitrate and placebo on headache and ability to work of healthy subjects].
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Headache; Humans; Isosorbide Dinitrate; Male; Pentaerythritol Tetranitrate; Vasodilator Agents; Work | 1998 |
Randomized, double-blind crossover study to investigate the effects of amlodipine and isosorbide mononitrate on the time course and severity of exercise-induced myocardial stunning.
Topics: Aged; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Echocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Stunning; Tomography, Emission-Computed, Single-Photon | 1998 |
Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Alprostadil; Cervical Ripening; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, First | 1998 |
Anti-ischemic and anti-anginal effects of controlled-release and conventional isosorbide-5-mononitrate in stable angina pectoris.
Topics: Aged; Angina Pectoris; Cross-Over Studies; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Vasodilator Agents | 1998 |
Effect of isosorbide-5-mononitrate on exercise performance and clinical status in patients with congestive heart failure. Results of the Nitrates in Congestive Heart Failure (NICE) Study.
Topics: Administration, Oral; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Diuretics; Double-Blind Method; Electrocardiography; Exercise Test; Female; Furosemide; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Quality of Life; Vasodilator Agents | 1999 |
Effect of isosorbide mononitrate on the human optic nerve and choroidal circulations.
Topics: Adult; Blood Flow Velocity; Blood Volume; Choroid; Cross-Over Studies; Double-Blind Method; Humans; Isosorbide Dinitrate; Optic Nerve; Vasodilator Agents; Visual Acuity | 1999 |
Comparative study for the identification of myocardial ischemia by contrast ventriculography under the effect of isosorbide mononitrate and by perfusional myocardial scintigraphy in patients with ischemic heart disease.
Topics: Female; Humans; Isosorbide Dinitrate; Male; Myocardial Ischemia; Radionuclide Ventriculography; Technetium Tc 99m Sestamibi; Vasodilator Agents; Ventricular Function, Left | 1999 |
Nitric oxide donors stimulate prostaglandin F(2alpha) and inhibit thromboxane B(2) production in the human cervix during the first trimester of pregnancy.
Topics: Base Sequence; Cervical Ripening; Cervix Uteri; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprost; DNA Primers; Female; Humans; Immunohistochemistry; Isoenzymes; Isosorbide Dinitrate; Membrane Proteins; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, First; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane B2 | 1999 |
[Functional activity of platelet guanylate cyclase and cardiac hemodynamics in patients with chronic heart failure and relevant changes after treatment with isosorbide-5-mononitrate].
Topics: Administration, Oral; Aged; Biomarkers; Blood Platelets; Delayed-Action Preparations; Electrocardiography; Endothelium, Vascular; Exercise Tolerance; Follow-Up Studies; Guanylate Cyclase; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Synthase; Treatment Outcome; Vasodilator Agents | 1999 |
Somatostatin plus isosorbide 5-mononitrate versus somatostatin in the control of acute gastro-oesophageal variceal bleeding: a double blind, randomised, placebo controlled clinical trial.
Topics: Acute Disease; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Male; Middle Aged; Somatostatin; Vasodilator Agents | 2000 |
Comparison of 50-mg and 100-mg sustained-release isosorbide mononitrate in the treatment of stable angina pectoris: effects on quality-of-life indices. Dutch Mononitrate Quality of Life (DUMQOL) Study Group.
Topics: Aged; Angina Pectoris; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Quality of Life; Vasodilator Agents | 1999 |
Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Ascites; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Nadolol; Randomized Controlled Trials as Topic | 2000 |
A controlled study of the effects of isosorbide mononitrate on arterial blood pressure and pulse wave form in systolic hypertension.
Topics: Aged; Blood Pressure; Cross-Over Studies; Diastole; Double-Blind Method; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Systole; Vasodilator Agents | 1999 |
Comparison of the initial hemodynamic effects of immediate-release versus sustained-release isosorbide-5-mononitrate following single oral doses.
Topics: Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 2000 |
Human retinal hemodynamics following administration of 5-isosorbide mononitrate.
Topics: Adult; Blood Flow Velocity; Cross-Over Studies; Double-Blind Method; Eye; Hemodynamics; Humans; Intraocular Pressure; Isosorbide Dinitrate; Laser-Doppler Flowmetry; Regional Blood Flow; Retinal Vessels; Time Factors; Vasodilator Agents | 2000 |
Safety and efficacy of Hartone in stable angina pectoris--an open comparative trial.
Topics: Angina Pectoris; Case-Control Studies; Female; Humans; Isosorbide Dinitrate; Male; Medicine, Ayurvedic; Middle Aged; Plant Extracts; Vasodilator Agents | 1999 |
Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding.
Topics: Adrenergic beta-Antagonists; Aged; Drug Synergism; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Propranolol; Secondary Prevention; Survival Analysis; Vasodilator Agents | 2000 |
Effects of angiotensin II blockade on nitric oxide blood levels in IgA nephropathy.
Topics: Adult; Aged; Albuminuria; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Enalapril; Female; Glomerulonephritis, IGA; Hemoglobins; Humans; Isosorbide Dinitrate; Losartan; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Reference Values; Renal Circulation | 2000 |
Echo-dipyridamole stress test evaluation of isosorbide-5-mononitrate efficacy and tolerance in patients with coronary heart disease: interplay with sympathetic activity.
Topics: Aged; Analysis of Variance; Blood Pressure; Coronary Disease; Cross-Over Studies; Dipyridamole; Double-Blind Method; Echocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Prospective Studies; Vasodilator Agents | 2000 |
Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Aged; Angina Pectoris; Blood Pressure; Contraindications; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2000 |
Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm.
Topics: Coronary Artery Bypass; Costs and Cost Analysis; Creatine Kinase; Diltiazem; Female; Humans; Isosorbide Dinitrate; Length of Stay; Male; Middle Aged; Nitroglycerin; Postoperative Complications; Prospective Studies; Radial Artery; Spasm; Vasodilator Agents | 2000 |
Headache characteristics during the development of tolerance to nitrates: pathophysiological implications.
Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Headache; Humans; Isosorbide Dinitrate; Male; Middle Aged; Migraine Disorders; Nitroglycerin; Severity of Illness Index; Vasodilator Agents | 2000 |
Induction of nitrate tolerance is not a useful treatment in cluster headache.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Cerebral Arteries; Cluster Headache; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Radial Artery; Temporal Arteries; Treatment Failure; Ultrasonography; Vasodilation; Vasodilator Agents | 2000 |
Should nitrates be used with beta blockers to prevent variceal bleeding?
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Nadolol; Vasodilator Agents | 2000 |
[Comparative study of isosorbide dinitrates and mononitrates in patients with ischemic heart disease and stable angina pectoris caused by stenosing coronary atherosclerosis].
Topics: Aged; Angina Pectoris; Coronary Artery Disease; Coronary Disease; Cost-Benefit Analysis; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Vasodilator Agents | 2000 |
Potential efficacy of nitric oxide for cervical ripening in pregnancy at term.
Topics: Cervical Ripening; Dinoprostone; Female; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Nitroglycerin; Pregnancy; Vasodilator Agents | 2000 |
Independent determinants of the efficacy of nitrate therapy.
Topics: Aged; Analysis of Variance; Angina Pectoris; Delayed-Action Preparations; Drug Administration Schedule; Endothelium, Vascular; Female; Humans; Isosorbide Dinitrate; Linear Models; Male; Nitric Oxide Donors; Quality of Life | 2000 |
Factors influencing efficacy of nitrate therapy for stable angina pectoris: a multiple linear regression analysis.
Topics: Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Diabetes Complications; Drug Administration Schedule; Humans; Hypercholesterolemia; Isosorbide Dinitrate; Linear Models; Nitric Oxide Donors; Quality of Life; Treatment Outcome; Vasodilator Agents | 2000 |
A comparison of isosorbide mononitrate, misoprostol and combination therapy for first trimester pre-operative cervical ripening: a randomised controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Cervical Ripening; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Misoprostol; Nitric Oxide Donors; Pregnancy; Treatment Outcome; Vasodilator Agents | 2001 |
Vaginal application of the nitric oxide donor isosorbide mononitrate for preinduction cervical ripening: a randomized controlled trial to determine effects on maternal and fetal hemodynamics.
Topics: Adolescent; Adult; Apgar Score; Blood Pressure; Cervical Ripening; Drug Administration Routes; Female; Fetus; Heart Rate; Heart Rate, Fetal; Hemodynamics; Humans; Infant, Newborn; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy; Umbilical Arteries; Vagina | 2001 |
Relative bioavailability of two isosorbide dinitrate sublingual tablet formulations administered as single doses in healthy subjects.
Topics: Administration, Sublingual; Adult; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Chromatography, Gas; Cross-Over Studies; Female; Humans; Isosorbide Dinitrate; Male; Therapeutic Equivalency; Vasodilator Agents | 2001 |
Circadian variation of heart rate variability and the rate of autonomic change in the morning hours in healthy subjects and angina patients.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina Pectoris; Aortic Bodies; Autonomic Nervous System; Circadian Rhythm; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Reference Values; Vasodilator Agents | 2001 |
Effect of long-acting isosorbide-5-mononitrate administration on large artery distensibility in patients with essential hypertension.
Topics: Administration, Oral; Aged; Blood Flow Velocity; Carotid Arteries; Female; Femoral Artery; Humans; Hypertension; Isosorbide Dinitrate; Longitudinal Studies; Male; Middle Aged; Pilot Projects; Vasodilator Agents | 2001 |
[The effect of long-term administration of isosorbide 5-mononitrate (Mononit), nitric oxide donor, on gallbladder emptying in patients with chronic stable angina].
Topics: Aged; Angina Pectoris; Chronic Disease; Drug Administration Schedule; Female; Gallbladder; Gallbladder Emptying; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Ultrasonography | 2001 |
[Mononitrates in therapy of ischemic heart disease polycythemia vera].
Topics: Adult; Aged; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Polycythemia Vera; Vasodilator Agents | 2001 |
Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding.
Topics: Actuarial Analysis; Adrenergic beta-Antagonists; Drug Therapy, Combination; Endoscopy; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Isosorbide Dinitrate; Ligation; Male; Middle Aged; Nadolol; Postoperative Complications; Regression Analysis; Secondary Prevention; Survival Analysis; Vasodilator Agents | 2001 |
Isosorbide mononitrate in the prevention of first variceal bleed in patients who cannot receive beta-blockers.
Topics: Adrenergic beta-Antagonists; Ascites; Contraindications; Double-Blind Method; Female; Gastroesophageal Reflux; Hemodynamics; Humans; Isosorbide Dinitrate; Kidney Function Tests; Liver Cirrhosis; Male; Middle Aged; Odds Ratio; Patient Selection; Probability; Prothrombin Time; Survival Rate | 2001 |
A double-blind, parallel-group study of amlodipine versus long-acting nitrate in the management of elderly patients with stable angina.
Topics: Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Double-Blind Method; Edema; Exercise Test; Exercise Tolerance; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Quality of Life; Time Factors; Vasodilator Agents | 2001 |
[Anti-ischemic efficacy of sustained-release isosorbide-5-mononitrate: echocardiography during mental and physical stress].
Topics: Adult; Angina Pectoris; Confidence Intervals; Data Interpretation, Statistical; Delayed-Action Preparations; Double-Blind Method; Echocardiography; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Placebos; Stress, Physiological; Stress, Psychological; Time Factors; Vasodilator Agents | 2001 |
Pharmacokinetic profile of a new controlled-release isosorbide-5-mononitrate 60 mg scored tablet (Monoket Multitab).
Topics: Adult; Analysis of Variance; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Dietary Fats; Drug Administration Schedule; Fasting; Food-Drug Interactions; Humans; Isosorbide Dinitrate; Male; Middle Aged; Tablets; Vasodilator Agents | 2002 |
TIPS versus drug therapy in preventing variceal rebleeding in advanced cirrhosis: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Aged; Drug Therapy, Combination; Female; Follow-Up Studies; Health Care Costs; Hemorrhage; Hepatic Encephalopathy; Humans; Isosorbide Dinitrate; Liver; Liver Cirrhosis; Male; Middle Aged; Portasystemic Shunt, Transjugular Intrahepatic; Propranolol; Prospective Studies; Quality of Life; Retreatment; Secondary Prevention; Varicose Veins | 2002 |
Topical mononitrate treatment in patients with anal fissure.
Topics: Administration, Topical; Adult; Aged; Female; Fissure in Ano; Humans; Hydrogels; Isosorbide Dinitrate; Male; Manometry; Middle Aged; Patient Compliance; Placebos; Treatment Outcome; Vasodilator Agents | 2002 |
Evaluation of the bioequivalence and pharmacokinetics of two tablet formulations of isosorbide-5-mononitrate after single oral administration in healthy volunteers.
Topics: Adult; Area Under Curve; Chromatography, Gas; Cross-Over Studies; Female; Humans; Isosorbide Dinitrate; Male; Tablets; Therapeutic Equivalency; Vasodilator Agents | 2002 |
Nitric oxide induced cervical ripening in the human: Involvement of cyclic guanosine monophosphate, prostaglandin F(2 alpha), and prostaglandin E(2).
Topics: Cervical Ripening; Cervix Uteri; Cyclic AMP; Cyclic GMP; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dinoprostone; Female; Gestational Age; Humans; Immunoblotting; Isoenzymes; Isosorbide Dinitrate; Membrane Proteins; Microscopy, Electron; Nitric Oxide; Nitric Oxide Donors; Pregnancy; Prostaglandin-Endoperoxide Synthases | 2002 |
[Multiple dose pharmacokinetic and bioavailability studies of oral sustained release and conventional formulations of isosorbide-5-mononitrate in healthy volunteers].
Topics: Adult; Area Under Curve; Biological Availability; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Male | 1998 |
[The influence of isosorbide mononitrate on skin blood flow in patients with Raynaud's syndrome].
Topics: Female; Fingers; Humans; Isosorbide Dinitrate; Laser-Doppler Flowmetry; Male; Raynaud Disease; Regional Blood Flow; Skin; Vasodilator Agents | 2002 |
Nadolol is superior to isosorbide mononitrate for the prevention of the first variceal bleeding in cirrhotic patients with ascites.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Ascites; Blood Pressure; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Heart Rate; Humans; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Male; Middle Aged; Nadolol; Survival Rate; Treatment Outcome; Vasodilator Agents | 2002 |
Randomized trial of isosorbide mononitrate versus misoprostol for cervical ripening at term.
Topics: Adult; Cervical Ripening; Female; Humans; Infant, Newborn; Isosorbide Dinitrate; Misoprostol; Obstetric Labor Complications; Oxytocics; Pregnancy; Pregnancy Outcome; Time Factors; Uterus; Vasodilator Agents | 2002 |
Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding.
Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Male; Middle Aged; Nadolol; Secondary Prevention; Treatment Failure; Vasodilator Agents | 2002 |
Primary prophylaxis of variceal hemorrhage: a randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate.
Topics: Antihypertensive Agents; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Male; Middle Aged; Prognosis; Propranolol; Secondary Prevention; Vasodilator Agents | 2002 |
A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Endoscopy; Esophageal and Gastric Varices; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Male; Middle Aged; Propranolol; Secondary Prevention; Vasodilator Agents; Venous Pressure | 2002 |
"A La Carte" treatment of portal hypertension: Adapting medical therapy to hemodynamic response for the prevention of bleeding.
Topics: Adult; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Male; Middle Aged; Propranolol; Secondary Prevention; Treatment Outcome; Vasodilator Agents; Venous Pressure | 2002 |
[The randomized controlled trial of isosorbide mononitrate plus propranolol compared with propranolol alone for the prevention of variceal rebleeding].
Topics: Adult; Dizziness; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Headache; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propranolol; Treatment Outcome; Vasodilator Agents | 2002 |
Serum profile of isosorbide mononitrate after vaginal administration in the third trimester.
Topics: Abortion, Induced; Administration, Intravaginal; Adult; Cervical Ripening; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, Third; Tablets; Time Factors | 2003 |
Randomized, double-blind, placebo-controlled long-term study of isosorbide-5-mononitrate therapy in patients with left ventricular dysfunction after acute myocardial infarction.
Topics: Aged; Atrial Natriuretic Factor; Delayed-Action Preparations; Diuretics; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Ramipril; Ventricular Dysfunction, Left | 2003 |
[Coronary artery disease observed in general hospitals: ETTIC study. Comparison between trimetazidine and mononitrate isosorbide for patients receiving betablockers].
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Coronary Artery Disease; Drug Therapy, Combination; Exercise Test; Hospitals, General; Humans; Isosorbide Dinitrate; Middle Aged; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2002 |
Low doses of isosorbide mononitrate attenuate the postprandial increase in portal pressure in patients with cirrhosis.
Topics: Aged; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide Donors; Portal Vein; Postprandial Period; Propranolol; Vasodilator Agents | 2003 |
[Quality of life and angina pectoris. Comparison of the effects of 2 nitrate derivatives administered discontinuously: transdermal 10 mg nitroglycerine patch (12 hours) and long-acting oral 40 mg isosorbide-5-mononitrate (once a day)].
Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Quality of Life; Vasodilator Agents | 2001 |
Effects of isosorbide mononitrate and AII inhibition on pulse wave reflection in hypertension.
Topics: Acrylates; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Imidazoles; Isosorbide Dinitrate; Male; Middle Aged; Pulse; Thiophenes; Time Factors; Vasodilator Agents | 2003 |
Nitric oxide and squamous carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Isosorbide Dinitrate; Mouth Neoplasms; Nitric Oxide; Nitric Oxide Donors; Prospective Studies | 2003 |
Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: a double-blind RCT.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Double-Blind Method; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Hemorrhage; Humans; Incidence; Isosorbide Dinitrate; Male; Middle Aged; Placebos; Propranolol; Severity of Illness Index; Survival Analysis; Vasodilator Agents | 2003 |
Beneficial effects of angiotensin-converting enzyme inhibitor and nitrate association on left ventricular remodeling in patients with large acute myocardial infarction: the Delapril Remodeling after Acute Myocardial Infarction (DRAMI) trial.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Indans; Isosorbide Dinitrate; Lisinopril; Male; Middle Aged; Myocardial Infarction; Placebo Effect; Statistics as Topic; Vasodilator Agents; Ventricular Remodeling | 2003 |
Aqueous humour flow after a single oral dose of isosorbide-5-mononitrate in healthy volunteers.
Topics: Administration, Oral; Adult; Aqueous Humor; Blood Pressure; Cross-Over Studies; Double-Blind Method; Female; Fluorophotometry; Humans; Intraocular Pressure; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Timolol; Tonometry, Ocular | 2003 |
[The impact of nitrates and mono-therapy and nitrates combined with angiotensin converting enzyme inhibitors on left ventricular remodeling and exercise capacity in patients after acute myocardial infarction].
Topics: Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Delayed-Action Preparations; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Donors; Time Factors; Treatment Outcome; Vasodilator Agents; Ventricular Function, Left; Ventricular Remodeling | 2003 |
Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave.
Topics: Aged; Aged, 80 and over; Angiotensin II; Arginine; Arteries; Blood Pressure; Circadian Rhythm; Cross-Over Studies; Diastole; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Posture; Pulse; Systole; Time Factors; Treatment Outcome; Vasoconstrictor Agents | 2003 |
A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation.
Topics: Abortion, Induced; Adolescent; Adult; Analysis of Variance; Cervical Ripening; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Middle Aged; Misoprostol; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Probability; Sensitivity and Specificity; Statistics, Nonparametric; Vacuum Curettage | 2003 |
A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy.
Topics: Abortifacient Agents, Steroidal; Abortion, Induced; Administration, Intravaginal; Adult; Cervical Ripening; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Misoprostol; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, Second; Prospective Studies; Treatment Outcome | 2003 |
Safety of nitrate withdrawal in angina-free and hemodynamically stable patients with coronary artery disease.
Topics: Aged; Angina Pectoris; Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Prospective Studies; Safety; Vasodilator Agents | 2003 |
Determination of isosorbide-5-mononitrate in human plasma by high-resolution gas chromatography.
Topics: Chromatography, Gas; Dimethylpolysiloxanes; Fluorenes; Humans; Indicators and Reagents; Isosorbide Dinitrate; Quality Control; Reference Standards; Reproducibility of Results; Silicones; Solutions; Vasodilator Agents | 2004 |
Vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening at term: a randomized controlled study.
Topics: Administration, Intravaginal; Adult; Cervical Ripening; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Probability; Reference Values; Risk Assessment; Statistics, Nonparametric; Treatment Outcome | 2003 |
Maintenance of hemodynamic response to treatment for portal hypertension and influence on complications of cirrhosis.
Topics: Adrenergic beta-Antagonists; Aged; Ascites; Esophageal and Gastric Varices; Female; Hemodynamics; Hepatic Encephalopathy; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Nadolol; Prognosis | 2004 |
Pharmacokinetics of three organic nitrates in Chinese healthy male volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chromatography, Gas; Cross-Over Studies; Electrocardiography; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Nitrates; Vasodilator Agents | 2004 |
Comparison of the time to onset of action on myocardial ischaemia following intravenous administration of isosorbide dinitrate and 5-isosorbide mononitrate in Chinese patients.
Topics: Acute Disease; Aged; Electrocardiography; Female; Humans; Injections, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tomography; Tomography, Emission-Computed; Vasodilator Agents | 2004 |
Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trial.
Topics: Aged; Aged, 80 and over; Biomarkers; Bone Density; Bone Resorption; Collagen; Collagen Type I; Female; Femur Neck; Humans; Isosorbide Dinitrate; Middle Aged; Osteogenesis; Osteoporosis, Postmenopausal; Peptides; Postmenopause; Treatment Outcome | 2004 |
Does administration of isosorbide mononitrate affect cellular proliferation in oral squamous cell carcinoma? A prospective randomized clinical study.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear; Antibodies, Monoclonal; Biopsy; Carcinoma, Squamous Cell; Cell Division; Chi-Square Distribution; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Ki-67 Antigen; Male; Middle Aged; Mouth Neoplasms; Nitric Oxide Donors; Placebos; Prospective Studies | 2004 |
Sex-related differences in the pharmacokinetics of isosorbide-5-mononitrate (60 mg) after repeated oral administration of two different original prolonged release formulations.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Sex Factors; Therapeutic Equivalency; Vasodilator Agents | 2004 |
Acute administration of carvedilol is more effective than propranolol plus isosorbide-5-mononitrate in the reduction of portal pressure in patients with viral cirrhosis.
Topics: Antihypertensive Agents; Carbazoles; Carvedilol; Drug Therapy, Combination; Female; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propanolamines; Propranolol; Vasodilator Agents | 2004 |
[Comparative effectiveness of different methods of diagnosis and correction of impaired portal circulation].
Topics: Antihypertensive Agents; Humans; Hypertension, Portal; Isosorbide Dinitrate; Laser Therapy; Liver Cirrhosis; Propranolol; Ultrasonography, Doppler; Vasodilator Agents | 2004 |
Different haemodynamic effects of a single dose of long-acting isosorbide-5-mononitrate in healthy subjects and patients with cirrhotic portal hypertension.
Topics: Aged; Blood Flow Velocity; Double-Blind Method; Fasting; Female; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Portal Pressure; Portal Vein; Time Factors; Treatment Outcome; Vasodilator Agents | 2004 |
Long-term effectiveness of extended-release nitrate for the treatment of systolic hypertension.
Topics: Aged; Aged, 80 and over; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Treatment Outcome; Vasodilator Agents | 2005 |
Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: a double-blind randomized, placebo-controlled multicenter trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Intravaginal; Alprostadil; Analysis of Variance; Female; Humans; Isosorbide Dinitrate; Multivariate Analysis; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, Second | 2005 |
Effects of a mononitrate, a beta1-blocker and a dihydropyridine calcium channel blocker on cardiovascular responsiveness to passive orthostasis: a placebo-controlled double-blind study in normotensive volunteers.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Female; Hemodynamics; Humans; Hypotension, Orthostatic; Isosorbide Dinitrate; Male; Nisoldipine; Nitric Oxide Donors; Supine Position; Tilt-Table Test | 2005 |
[Efficacy of conventional mono mac therapy and mono mac chronotherapy of painless myocardial ischemia in patients with insulin-independent diabetes].
Topics: Aged; Chronotherapy; Diabetes Mellitus, Type 2; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Vasodilator Agents | 2005 |
Comparison of isosorbide mononitrate (Mono Mack) and misoprostol (Cytotec) for cervical ripening in the first trimester missed abortion.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Missed; Administration, Intravaginal; Cervical Ripening; Female; Humans; Isosorbide Dinitrate; Misoprostol; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Treatment Outcome | 2005 |
[Effects of isosorbide-5-mononitrate on esophageal manometry of cirrhotic patients with esophageal varices].
Topics: Adult; Esophageal and Gastric Varices; Esophagus; Female; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Manometry; Vasodilator Agents | 2005 |
Evaluation of endoscopic variceal ligation (EVL) versus propanolol plus isosorbide mononitrate/nadolol (ISMN) in the prevention of variceal rebleeding: comparison of cirrhotic and noncirrhotic patients.
Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Endoscopy, Digestive System; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Male; Middle Aged; Nadolol; Propranolol; Secondary Prevention; Vasodilator Agents | 2005 |
Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy.
Topics: Female; Heart; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Sympathetic Nervous System; Ventricular Function, Left | 2005 |
Preservation of platelet responsiveness to nitroglycerine despite development of vascular nitrate tolerance.
Topics: Aged; Angina Pectoris; Blood Platelets; Cross-Over Studies; Delayed-Action Preparations; Drug Resistance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Platelet Aggregation; Vasodilator Agents | 2005 |
[Paired bicycle exercise test in assessment of clinical efficacy of isosorbide-5-mononitrate in patients with stable angina of effort].
Topics: Aged; Angina Pectoris; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion; Vasodilator Agents | 2005 |
[Efficacy of isosorbide-5-mononitrate retard in patients with stable exertional angina].
Topics: Aged; Angina Pectoris; Delayed-Action Preparations; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion; Quality of Life; Surveys and Questionnaires; Vasodilator Agents | 2005 |
Lipid peroxidation is not increased in heart failure patients on modern pharmacological therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Captopril; Comorbidity; Delayed-Action Preparations; Dinoprost; Female; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Lipid Peroxidation; Losartan; Male; Malondialdehyde; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Nitric Oxide Donors; Oxidative Stress; Ramipril; Stroke Volume; Ultrasonography; Ventricular Dysfunction, Left | 2006 |
[Selection of therapy with nitrates in patients with stable effort angina: results of comparative study of common isosorbide dinitrate and long acting preparation of isosorbide-5-mononitrate].
Topics: Aged; Angina Pectoris; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 2005 |
Pharmacologic treatment of portal hypertension in the prevention of community-acquired spontaneous bacterial peritonitis.
Topics: Adrenergic beta-Antagonists; Bacterial Infections; Community-Acquired Infections; Drug Therapy, Combination; Epidemiologic Methods; Esophageal and Gastric Varices; Esophagoscopy; Female; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Ligation; Male; Middle Aged; Nadolol; Peritonitis; Sclerotherapy; Secondary Prevention; Vasodilator Agents | 2006 |
A randomized clinical trial of the effects of isosorbide mononitrate on bone formation and resorption in post-menopausal women: a pilot study.
Topics: Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Density; Bone Remodeling; Bone Resorption; Collagen Type I; Female; Humans; Isosorbide Dinitrate; Middle Aged; Nitric Oxide Donors; Osteogenesis; Osteoporosis, Postmenopausal; Peptides; Pilot Projects; Postmenopause | 2006 |
Hemodynamic effects of sildenafil citrate and isosorbide mononitrate in men with coronary artery disease and erectile dysfunction.
Topics: Adult; Coronary Artery Disease; Double-Blind Method; Drug Administration Schedule; Erectile Dysfunction; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Piperazines; Purines; Sildenafil Citrate; Sulfones; Vasodilator Agents | 2005 |
The "PRIM" study: a randomized comparison of prostaglandin E2 gel with the nitric oxide donor isosorbide mononitrate for cervical ripening before the induction of labor at term.
Topics: Adult; Cervical Ripening; Dinoprostone; Double-Blind Method; Female; Gels; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Oxytocics; Pregnancy | 2006 |
Use of antihypertension agents for the suppression of arterial pulse pressure waveforms in patients with intracranial aneurysms.
Topics: Adult; Aged; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Brain; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Intracranial Aneurysm; Irbesartan; Isosorbide Dinitrate; Male; Middle Aged; Perindopril; Risk Factors; Tetrazoles; Treatment Outcome | 2006 |
Isosorbide mononitrate induces increased cervical expression of cyclooxygenase-2, but not of cyclooxygenase-1, at term.
Topics: Biopsy; Cervical Ripening; Cervix Uteri; Cyclooxygenase 1; Cyclooxygenase 2; Epithelial Cells; Female; Humans; Immunohistochemistry; Isosorbide Dinitrate; Nitric Oxide; Pregnancy; Prostaglandins | 2007 |
Induction of labor at term using isosorbide mononitrate simultaneously with dinoprostone compared to dinoprostone treatment alone: a randomized, controlled trial.
Topics: Administration, Intravaginal; Adult; Delivery, Obstetric; Dinoprostone; Double-Blind Method; Drug Therapy, Combination; Female; Headache; Humans; Isosorbide Dinitrate; Labor, Induced; Oxytocics; Pregnancy; Time Factors | 2006 |
Comparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: a randomized controlled trial.
Topics: Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Male; Middle Aged; Nadolol; Sclerotherapy; Secondary Prevention | 2006 |
Effectiveness of oral route isosorbide 5-mononitrate on peritoneal solute and fluid transports in CAPD patients.
Topics: Administration, Oral; Biological Transport; Cross-Over Studies; Dialysis Solutions; Female; Humans; Isosorbide Dinitrate; Male; Metabolic Clearance Rate; Nitric Oxide Donors; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Treatment Outcome | 2006 |
Moderate exercise decreases nitric oxide exhalation in patients with stable coronary artery disease.
Topics: Breath Tests; Coronary Artery Disease; Exercise; Exhalation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors | 2006 |
Neurohumoral changes in patients with left ventricular dysfunction following acute myocardial infarction and the effect of nitrate therapy: a randomized, double-blind, placebo-controlled long-term study.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Double-Blind Method; Echocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Norepinephrine; Renin; Substance P; Ventricular Dysfunction, Left | 2006 |
Comparison of endoscopic variceal ligation and nadolol plus isosorbide-5-mononitrate in the prevention of first variceal bleeding in cirrhotic patients.
Topics: Adult; Aged; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Male; Middle Aged; Nadolol | 2006 |
Efficacy and safety of controlled-release isosorbide-5-mononitrate in Japanese patients with stable effort angina pectoris.
Topics: Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Exercise Test; Exercise Tolerance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Reproducibility of Results; Treatment Outcome; Vasodilator Agents | 2006 |
Outpatient vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening and labor induction postterm: a randomized controlled study.
Topics: Administration, Intravaginal; Adult; Ambulatory Care; Cervical Ripening; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy; Pregnancy, Prolonged | 2007 |
Outpatient cervical ripening before first-trimester surgical abortion: a comparison between misoprostol and isosorbide mononitrate.
Topics: Abdominal Pain; Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Intravaginal; Adolescent; Adult; Ambulatory Care; Cervical Ripening; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Misoprostol; Nausea; Nitric Oxide Donors; Pregnancy; Pregnancy Trimester, First; Self Administration; Surveys and Questionnaires; Uterine Hemorrhage | 2007 |
Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism.
Topics: Adolescent; Adult; Ascorbic Acid; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; Free Radicals; Humans; Isosorbide Dinitrate; Male; Regional Blood Flow; Vasoconstriction; Vasodilation | 2007 |
Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; China; Double-Blind Method; Exercise; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Nitroglycerin; Vasodilator Agents | 2007 |
Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion.
Topics: Adult; Double-Blind Method; Endothelium, Vascular; Humans; Ischemic Preconditioning; Isosorbide Dinitrate; Male; Nitroglycerin; Pentaerythritol Tetranitrate; Reperfusion Injury; Vasodilator Agents | 2007 |
Nitric oxide donor isosorbide mononitrate for pre-induction cervical ripening at 41 weeks' gestation: A randomized controlled trial.
Topics: Administration, Intravaginal; Adult; Blood Pressure; Cervical Ripening; Delayed-Action Preparations; Double-Blind Method; Female; Heart Rate; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Pregnancy | 2007 |
[Evaluation of different methods of treatment of patients with stable stenocardia combined with arterial hypertension according to echocardiographic data].
Topics: Adult; Aged; Angina Pectoris; Chronotherapy; Comorbidity; Drug Therapy, Combination; Echocardiography; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Melatonin; Middle Aged; Severity of Illness Index; Treatment Outcome; Vasodilator Agents; Ventricular Function, Left | 2007 |
Isosorbide mononitrate vaginal gel versus misoprostol vaginal gel versus Dilapan-S for cervical ripening before first trimester curettage.
Topics: Abortion, Missed; Adolescent; Adult; Cervical Ripening; Dilatation and Curettage; Female; Humans; Isosorbide Dinitrate; Misoprostol; Oxytocics; Polymers; Pregnancy; Pregnancy Trimester, First; Vaginal Creams, Foams, and Jellies | 2008 |
Outpatient cervical ripening with nitric oxide donor isosorbide mononitrate prior to induction of labor.
Topics: Administration, Intravaginal; Adult; Ambulatory Care; Cervical Ripening; Cervix Uteri; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy; Treatment Outcome; Uterine Contraction | 2008 |
Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate.
Topics: Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Middle Cerebral Artery; Nitric Oxide Donors; Severity of Illness Index; Time Factors; Ultrasonography, Doppler, Transcranial | 2008 |
Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Digestive System Surgical Procedures; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Kaplan-Meier Estimate; Ligation; Male; Middle Aged; Nadolol; Secondary Prevention; Treatment Outcome; Vasodilator Agents | 2008 |
Isosorbide mononitrate versus alendronate for postmenopausal osteoporosis.
Topics: Absorptiometry, Photon; Alendronate; Bone Density; Bone Density Conservation Agents; Confidence Intervals; Female; Hospitals, University; Humans; Isosorbide Dinitrate; Middle Aged; Nitric Oxide Donors; Osteoporosis, Postmenopausal; Treatment Outcome | 2008 |
Clinical trial: a randomized controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological therapy.
Topics: Antihypertensive Agents; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Male; Middle Aged; Nadolol; Secondary Prevention; Venous Pressure | 2009 |
Cervical priming in the first trimester: morphological and biochemical effects of misoprostol and isosorbide mononitrate.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Therapeutic; Administration, Intravaginal; Adult; Cervical Ripening; Cervix Uteri; Female; Follow-Up Studies; Humans; Immunohistochemistry; Isosorbide Dinitrate; Microscopy, Electron; Misoprostol; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Preoperative Care; Probability; Statistics, Nonparametric; Sweden; Treatment Outcome; Young Adult | 2009 |
Pharmacokinetic interaction of the direct renin inhibitor aliskiren with furosemide and extended-release isosorbide-5-mononitrate in healthy subjects.
Topics: Adolescent; Adult; Amides; Area Under Curve; Blood Pressure; Cross-Over Studies; Delayed-Action Preparations; Diuretics; Drug Interactions; Female; Fumarates; Furosemide; Humans; Isosorbide Dinitrate; Male; Middle Aged; Renin; Vasodilator Agents; Young Adult | 2008 |
Topical anal fissure treatment: placebo-controlled study of mononitrate and trinitrate therapies.
Topics: Administration, Topical; Adolescent; Adult; Aged; Female; Fissure in Ano; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Placebos; Treatment Outcome; Vasodilator Agents | 2009 |
Nadolol plus isosorbide mononitrate alone or associated with band ligation in the prevention of recurrent bleeding: a multicentre randomised controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Combined Modality Therapy; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Male; Middle Aged; Nadolol; Prospective Studies; Secondary Prevention; Survival Analysis; Treatment Outcome; Vasodilator Agents | 2009 |
Comparison of exercise-rest-reinjection Tl-201 imaging and rest sublingual isosorbide dinitrate Tc-99m MIBI imaging for the assessment of myocardial viability.
Topics: Administration, Sublingual; Chronic Disease; Coronary Artery Disease; Exercise; Female; Heart; Hemodynamics; Humans; Injections; Isosorbide Dinitrate; Male; Middle Aged; Myocardium; Rest; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Tissue Survival; Tomography, Emission-Computed, Single-Photon; Ventricular Dysfunction, Left | 2009 |
Propranolol, isosorbide mononitrate and endoscopic band ligation - alone or in varying combinations for the prevention of esophageal variceal rebleeding.
Topics: Adult; Aged; Combined Modality Therapy; Endoscopy; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Middle Aged; Propranolol; Secondary Prevention; Vasodilator Agents; Young Adult | 2009 |
Oral nitrate therapy does not affect glucose metabolism in healthy men.
Topics: Adult; Blood Glucose; Cyclic GMP; Delayed-Action Preparations; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pentaerythritol Tetranitrate; Pulmonary Circulation | 2009 |
Addition of propranolol and isosorbide mononitrate to endoscopic variceal ligation does not reduce variceal rebleeding incidence.
Topics: Adult; Combined Modality Therapy; Endoscopy, Digestive System; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Ligation; Liver Circulation; Male; Propranolol; Risk Factors; Secondary Prevention; Vasodilator Agents; Venous Pressure | 2009 |
The cost-effectiveness of outpatient (at home) cervical ripening with isosorbide mononitrate prior to induction of labour.
Topics: Ambulatory Care; Cervical Ripening; Cost-Benefit Analysis; Female; Health Care Costs; Home Care Services; Hospitalization; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy; Prenatal Care | 2009 |
Randomised placebo-controlled trial of outpatient (at home) cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour--clinical trial with analyses of efficacy and acceptability. The IMOP study.
Topics: Administration, Intravaginal; Adult; Ambulatory Care; Cervical Ripening; Double-Blind Method; Female; Home Care Services; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Patient Satisfaction; Pregnancy | 2009 |
A randomized, controlled trial of banding ligation plus drug therapy versus drug therapy alone in the prevention of esophageal variceal rebleeding.
Topics: Adrenergic beta-Antagonists; Chi-Square Distribution; Combined Modality Therapy; Esophageal and Gastric Varices; Female; Humans; Isosorbide Dinitrate; Ligation; Male; Middle Aged; Nadolol; Proportional Hazards Models; Recurrence; Treatment Outcome; Vasodilator Agents | 2009 |
The home as an appropriate setting for women undertaking cervical ripening before the induction of labour.
Topics: Administration, Intravaginal; Adult; Ambulatory Care; Cervical Ripening; Delavirdine; Female; Home Care Services; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Patient Satisfaction; Pregnancy; United Kingdom; Young Adult | 2011 |
Preparation and evaluation of isosorbide mononitrate hydrogels for topical fissure treatment.
Topics: Acrylic Resins; Administration, Topical; Diffusion; Female; Fissure in Ano; Humans; Hydrogels; Hydrophobic and Hydrophilic Interactions; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Poloxamer; Viscosity | 2012 |
Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Treatment Outcome | 2010 |
Comparison of isosorbide mononitrate and misoprostol for cervical ripening in termination of pregnancy between 8 and 12 weeks: a randomized controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Intravaginal; Adult; Blood Loss, Surgical; Cervical Ripening; Female; Hospitals, Teaching; Humans; India; Isosorbide Dinitrate; Labor Stage, First; Misoprostol; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Single-Blind Method; Treatment Outcome; Vacuum Curettage; Young Adult | 2011 |
Oral misoprostol and vaginal isosorbide mononitrate for labor induction: a randomized controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Administration, Intravaginal; Administration, Oral; Adult; Cesarean Section; Female; Headache; Heart Rate, Fetal; Humans; Isosorbide Dinitrate; Labor, Induced; Misoprostol; Pregnancy; Prospective Studies; Uterine Contraction | 2010 |
Effect of isosorbide mononitrate for cervical ripening before surgical termination of pregnancy in the first trimester.
Topics: Abortion, Induced; Adult; Cervical Ripening; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Labor Stage, First; Pregnancy; Pregnancy Trimester, First; Preoperative Care; Treatment Outcome; Vacuum Curettage; Vasodilator Agents | 2010 |
Intravaginal administration of isosorbide mononitrate and misoprostol for cervical ripening and induction of labour: a randomized controlled trial.
Topics: Administration, Intravaginal; Adult; Cervical Ripening; Double-Blind Method; Drug Synergism; Female; Humans; Infant, Newborn; Isosorbide Dinitrate; Labor, Induced; Misoprostol; Nitric Oxide Donors; Oxytocics; Pregnancy; Prospective Studies; Young Adult | 2011 |
Association of GSTM1 null polymorphism with isosorbide-5-mononitrate cardiovascular response and involvement of CGRP in healthy Chinese male volunteers.
Topics: Adult; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Blood Pressure; Calcitonin Gene-Related Peptide; Cardiovascular System; China; Glutathione Transferase; Heart Rate; Humans; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Vasodilator Agents | 2011 |
Adding banding ligation is effective as rescue therapy to prevent variceal rebleeding in haemodynamic non-responders to pharmacological therapy.
Topics: Acute Disease; Aged; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Liver Cirrhosis; Male; Middle Aged; Nadolol; Secondary Prevention; Somatostatin; Treatment Outcome | 2012 |
Comparative evaluation of isosorbide mononitrate and alendronate in management of postmenopausal osteoporosis.
Topics: Absorptiometry, Photon; Aged; Alendronate; Bone Density Conservation Agents; Bone Remodeling; Female; Humans; Isosorbide Dinitrate; Middle Aged; Osteoporosis, Postmenopausal; Prospective Studies | 2012 |
The efficacy of two different doses of vaginal isosorbide mononitrate in pre induction cervical ripening: a double blind randomised controlled trial.
Topics: Administration, Intravaginal; Cervical Ripening; Double-Blind Method; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy | 2011 |
Intravenous diuretic and vasodilator therapy reduce plasma brain natriuretic peptide levels in acute exacerbation of chronic obstructive pulmonary disease.
Topics: Aged; Aminophylline; Bronchodilator Agents; Disease Progression; Drug Combinations; Female; Furosemide; Glucocorticoids; Health Status; Health Status Indicators; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Methylprednisolone; Middle Aged; Natriuretic Peptide, Brain; Pulmonary Disease, Chronic Obstructive; Quality of Life; Vasodilator Agents | 2012 |
Evaluation of isosorbide mononitrate for cervical ripening prior to induction of labor for postdated pregnancy in an outpatient setting.
Topics: Adult; Cervical Ripening; Female; Fetal Mortality; Gestational Age; Humans; Isosorbide Dinitrate; Labor, Induced; Maternal Mortality; Nitric Oxide Donors; Oxytocics; Oxytocin; Patient Satisfaction; Pregnancy; Pregnancy, Prolonged; Self Administration; Treatment Outcome; Young Adult | 2012 |
A randomized phase II study of irinotecan plus cisplatin versus irinotecan plus capecitabine with or without isosorbide-5-mononitrate in advanced non-small-cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Isosorbide Dinitrate; Lung Neoplasms; Male; Middle Aged; Nitroglycerin; Treatment Outcome | 2012 |
Randomized, controlled trial of carvedilol versus nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilol; Chi-Square Distribution; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Hemostasis, Endoscopic; Humans; Hypertension, Portal; Isosorbide Dinitrate; Kaplan-Meier Estimate; Ligation; Male; Middle Aged; Nadolol; Propanolamines; Proportional Hazards Models; Secondary Prevention; Vasodilator Agents | 2012 |
Interruption of a study of cervical ripening with isosorbide mononitrate due to adverse effects.
Topics: Administration, Intravaginal; Adult; Cardiotocography; Cervical Ripening; Cervix Uteri; Early Termination of Clinical Trials; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Patient Satisfaction; Pilot Projects; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Ultrasonography, Prenatal; Young Adult | 2012 |
In vitro and in vivo evaluation of novel osmotic pump tablets of isosorbide-5-mononitrate containing polyvinyl pyrrolidone (PVP) for controlled release.
Topics: Adult; Area Under Curve; Biological Availability; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diuretics; Drug Delivery Systems; Drug Stability; Drug Storage; Humans; Isosorbide Dinitrate; Male; Membranes, Artificial; Osmosis; Pharmaceutic Aids; Povidone; Solutions; Young Adult | 2012 |
Can isosorbide mononitrate be useful in second trimester termination of pregnancies?
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Eugenic; Administration, Intravaginal; Adult; Cervical Ripening; Cohort Studies; Dose-Response Relationship, Drug; Female; Greece; Hospitals, Maternity; Humans; Isosorbide Dinitrate; Misoprostol; Nitric Oxide Donors; Parity; Pregnancy; Pregnancy Trimester, Second; Tablets; Time Factors | 2013 |
Organic nitrates favor regression of left ventricular hypertrophy in hypertensive patients on chronic peritoneal dialysis.
Topics: Adult; Aged; Antihypertensive Agents; Arginine; Blood Pressure; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Isosorbide Dinitrate; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Time Factors; Treatment Outcome; Vasodilator Agents | 2013 |
Effects of propranolol or propranolol plus isosorbide-5-mononitrate on variceal pressure in schistosomiasis.
Topics: Adult; China; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Male; Middle Aged; Portal Pressure; Propranolol; Schistosomiasis; Time Factors; Treatment Outcome; Vasodilator Agents | 2013 |
Long-term isosorbide mononitrate treatment impairs endothelial function in patients with coronary artery disease.
Topics: Administration, Oral; Aged; Biomarkers; Brachial Artery; C-Reactive Protein; China; Coronary Artery Disease; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; Female; Humans; Isosorbide Dinitrate; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Prospective Studies; Superoxide Dismutase; Time Factors; Treatment Outcome; Vasodilation; Vasodilator Agents | 2013 |
Nitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial.
Topics: Administration, Cutaneous; Administration, Sublingual; Age Factors; Biomarkers; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Chemistry, Pharmaceutical; Clinical Protocols; Female; Headache; Humans; Isosorbide Dinitrate; Middle Aged; Nitrates; Nitroglycerin; Ointments; Ontario; Postmenopause; Research Design; Tablets; Time Factors; Transdermal Patch; Treatment Outcome | 2013 |
Comparison of topical isosorbide mononitrate, topical diltiazem, and their combination in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Calcium Channel Blockers; Chronic Disease; Diltiazem; Drug Therapy, Combination; Female; Fissure in Ano; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Pain Measurement; Treatment Outcome | 2013 |
Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Clinical Protocols; Delayed-Action Preparations; Double-Blind Method; Elasticity; Humans; Hypertension; Isosorbide Dinitrate; Pulse Wave Analysis; Research Design; Spain; Time Factors; Treatment Outcome; Vascular Stiffness; Vasodilator Agents | 2013 |
[Autonomous pharmacodynamics of organic nitrates in patients with unstable angina].
Topics: Angina, Unstable; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Treatment Outcome; Vasodilator Agents | 2013 |
Evaluation of novel immediate-/controlled-release tablets of isosorbide-5-mononitrate (5-ISMN): in vitro-in vivo correlation.
Topics: Adult; Algorithms; Area Under Curve; Biological Availability; Cellulose; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Drug Delivery Systems; Excipients; Half-Life; Humans; Isosorbide Dinitrate; Male; Molecular Weight; Osmosis; Polyethylene Glycols; Solubility; Tablets; Vasodilator Agents; Young Adult | 2014 |
Comparison of the efficacy of isosorbide mononitrate and doxazosin in the treatment of lower urinary tract symptoms and benign prostatic hyperplasia: a randomized clinical trial.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Doxazosin; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Lower Urinary Tract Symptoms; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Urinary Retention | 2014 |
Outpatient cervical ripening by nitric oxide donors for prolonged pregnancy: a randomized controlled trial.
Topics: Adult; Cervical Ripening; Cesarean Section; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Pregnancy; Pregnancy, Prolonged | 2014 |
Comparing vaginal misoprostol versus Foley catheter plus vaginal isosorbide mononitrate for labor induction.
Topics: Administration, Intravaginal; Adult; Cervical Ripening; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Misoprostol; Nitric Oxide Donors; Oxytocics; Pregnancy; Prospective Studies; Young Adult | 2016 |
CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway.
Topics: Administration, Oral; Adult; Allopurinol; Antihypertensive Agents; Asian People; Blood Pressure; Calcitonin Gene-Related Peptide; Cells, Cultured; China; Enzyme Inhibitors; Healthy Volunteers; Humans; Isosorbide Dinitrate; Leukocytes, Mononuclear; Male; RNA, Messenger; Signal Transduction; Vasodilator Agents; Xanthine Oxidase | 2015 |
Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Atherosclerosis; Biomarkers; Female; Humans; Isosorbide Dinitrate; Leukocytes; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Prospective Studies; rho-Associated Kinases | 2015 |
Poor tolerance and limited effects of isosorbide-5-mononitrate in microvascular angina.
Topics: Adrenergic beta-Antagonists; Aged; Brachial Artery; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Echocardiography, Doppler; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Microvascular Angina; Middle Aged; Quality of Life; Vasodilator Agents | 2015 |
The role of sustained release isosorbide mononitrate on corticosteroid-induced hypertension in healthy human subjects.
Topics: Adult; Anti-Inflammatory Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Healthy Volunteers; Humans; Hydrocortisone; Hypertension; Isosorbide Dinitrate; Male; Nitrates; Nitric Oxide Donors; Nitrites; Young Adult | 2015 |
Prevention of Rebleeding From Esophageal Varices in Patients With Cirrhosis Receiving Small-Diameter Stents Versus Hemodynamically Controlled Medical Therapy.
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Germany; Humans; Isosorbide Dinitrate; Kaplan-Meier Estimate; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide Donors; Portasystemic Shunt, Transjugular Intrahepatic; Propranolol; Prospective Studies; Prosthesis Design; Quality of Life; Recurrence; Stents; Time Factors; Treatment Outcome; Vasodilator Agents; Venous Pressure | 2015 |
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
Topics: Accelerometry; Aged; Cross-Over Studies; Double-Blind Method; Exercise Tolerance; Female; Heart Failure; Humans; Isosorbide Dinitrate; Male; Middle Aged; Motor Activity; Natriuretic Peptide, Brain; Peptide Fragments; Quality of Life; Stroke Volume; Vasodilator Agents; Walking | 2015 |
Towards a pragmatic human migraine model for drug testing: 2. Isosorbide-5-mononitrate in healthy individuals.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; Humans; Isosorbide Dinitrate; Male; Middle Aged; Migraine Disorders; Models, Biological; Serotonin 5-HT1 Receptor Agonists; Sumatriptan; Vasodilator Agents | 2017 |
Nitric oxide donors increase the pregnancy rate in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination: a randomized controlled pilot study.
Topics: Administration, Intravaginal; Adult; Clomiphene; Egypt; Endometrium; Female; Fertility Agents, Female; Follicular Phase; Hospitals, University; Humans; Infertility, Female; Insemination, Artificial; Isosorbide Dinitrate; Nitric Oxide Donors; Ovulation Induction; Pilot Projects; Pregnancy; Pregnancy Rate; Regional Blood Flow; Tablets; Uterine Artery; Vascular Resistance; Vasodilator Agents; Young Adult | 2017 |
A randomized trial to assess whether portal pressure guided therapy to prevent variceal rebleeding improves survival in cirrhosis.
Topics: Adrenergic beta-Antagonists; Aged; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Portal Pressure; Recurrence; Spain | 2017 |
Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mon
Topics: Age Factors; Cerebral Small Vessel Diseases; Cilostazol; Cognition Disorders; Dementia; Double-Blind Method; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Severity of Illness Index; Treatment Outcome; United Kingdom; Vasodilator Agents | 2018 |
Microvascular ischemia in patients with successful percutaneous coronary intervention: effects of ranolazine and isosorbide-5-mononitrate.
Topics: Aged; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Cross-Over Studies; Female; Humans; Isosorbide Dinitrate; Male; Microcirculation; Microvessels; Middle Aged; Percutaneous Coronary Intervention; Ranolazine; Rome; Single-Blind Method; Time Factors; Treatment Outcome; Vasodilator Agents | 2018 |
Physical Activity, Quality of Life, and Biomarkers in Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction (from the NEAT-HFpEF Trial).
Topics: Accelerometry; Aged; Aged, 80 and over; Atrial Fibrillation; Biomarkers; Cross-Over Studies; Double-Blind Method; Exercise; Exercise Tolerance; Female; Follow-Up Studies; Heart Failure; Humans; Isosorbide Dinitrate; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Prognosis; Protein Precursors; Quality of Life; Stroke Volume | 2019 |
Intravaginal administration of isosorbide mononitrate for cervical ripening in prolonged pregnancy: a randomised clinical trial.
Topics: Administration, Intravaginal; Adult; Cervical Ripening; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Misoprostol; Nitric Oxide Donors; Oxytocics; Pregnancy; Pregnancy, Prolonged; Treatment Outcome | 2020 |
Evaluating the efficacy of outpatient use of isosorbide mononitrate on cervical ripening in pregnant women with unfavourable cervix.
Topics: Administration, Intravaginal; Adult; Ambulatory Care; Cervical Ripening; Cervix Uteri; Delivery, Obstetric; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy; Treatment Outcome; Uterine Cervical Incompetence | 2021 |
Isosorbide mononitrate for cervical ripening in induction of labor for pregnant women with PROM at or post term.
Topics: Administration, Intravaginal; Cervical Ripening; Female; Humans; Infant, Newborn; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Oxytocics; Pregnancy; Pregnant Women; Prospective Studies | 2021 |
Achieving Optimal Medical Therapy: Insights From the ORBITA Trial.
Topics: Amlodipine; Bisoprolol; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Fractional Flow Reserve, Myocardial; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isosorbide Dinitrate; Male; Middle Aged; Nicorandil; Percutaneous Coronary Intervention; Ranolazine; Treatment Outcome; Vasodilator Agents | 2021 |
Addition of vaginal isosorbide mononitrate for labor induction in pregnancies complicated by hypertensive diseases of pregnancy: a randomized controlled trial.
Topics: Cervical Ripening; Female; Humans; Hypertension; Isosorbide Dinitrate; Labor, Induced; Nitric Oxide Donors; Pregnancy | 2021 |
Sustained-release isosorbide mononitrate as adjuvant treatment in isolated systolic hypertension in the elderly.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Hypertension; Isosorbide Dinitrate; Male | 2022 |
Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial.
Topics: Aged; Cerebral Small Vessel Diseases; Cilostazol; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Lipoproteins; Magnetic Resonance Imaging; Male; Middle Aged; Treatment Outcome; Vasodilator Agents | 2022 |
Vericiguat in combination with isosorbide mononitrate in patients with chronic coronary syndromes: The randomized, phase Ib, VISOR study.
Topics: Adult; Double-Blind Method; Heart Failure; Heterocyclic Compounds, 2-Ring; Humans; Isosorbide Dinitrate; Pyrimidines; Syndrome | 2022 |
413 other study(ies) available for isosorbide dinitrate and isosorbide-5-mononitrate
| Article | Year |
|---|---|
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effect of lisinopril and isosorbide-5-mononitrate on hemodynamics and mortality in rats with permanent coronary artery occlusion.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Coronary Disease; Dipeptides; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Hemodynamics; Isosorbide Dinitrate; Lisinopril; Male; Peptidyl-Dipeptidase A; Rats | 1992 |
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
Topics: Animals; Antioxidants; Aorta, Thoracic; Drug Tolerance; Female; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Nitrates; Nitroglycerin; Parasympatholytics; Rabbits; Vasodilator Agents | 1992 |
Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of the guinea-pig and dog.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dogs; Guinea Pigs; Heart; In Vitro Techniques; Isosorbide Dinitrate; Myocardial Contraction; Vasodilator Agents | 1992 |
[The association of amlodipine with isosorbide-5-mononitrate in the treatment of ischemic-hypertensive cardiopathy].
Topics: Adult; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Vasodilator Agents | 1992 |
Preparation of multi-chamber gastrointestinal diffusion system for isosorbide-5-mononitrate.
Topics: Diffusion; Intestinal Absorption; Isosorbide Dinitrate; Models, Biological; Vasodilator Agents | 1992 |
Cardiovascular effects of the new nitric oxide donor, pirsidomine. Hemodynamic profile and tolerance studies in anesthetized and conscious dogs.
Topics: Administration, Oral; Animals; Dogs; Drug Tolerance; Female; Hemodynamics; Hypertension, Renal; Injections, Intravenous; Isosorbide Dinitrate; Male; Nitric Oxide; Sydnones; Vasodilator Agents | 1992 |
Pharmacokinetics of the organic nitrates trans-2-amino-2-methyl-N-(4- nitroxycyclohexylmethyl)-propionamide in dogs, and of 4-(2-nitroxyethyl)-piperidine in dogs and in monkeys.
Topics: Administration, Oral; Amides; Animals; Biological Availability; Chromatography, Gas; Dogs; Female; Half-Life; Injections, Intravenous; Isosorbide Dinitrate; Macaca; Male; Nitrates; Piperidines; Vasodilator Agents | 1992 |
Comparison of pharmacokinetics and pharmacodynamics of one-week monotherapy with IS-5-N s.r. 50 or 100 mg, ISDN s.r. 120 mg or IS-5-N 2 x 20 mg in coronary heart disease patients.
Topics: Blood Pressure; Coronary Disease; Humans; Isosorbide Dinitrate; Pulmonary Artery; Vasodilator Agents | 1992 |
Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate.
Topics: Adult; Arteries; Dose-Response Relationship, Drug; Double-Blind Method; Forearm; Headache; Humans; Isosorbide Dinitrate; Multivariate Analysis; Random Allocation; Reference Values; Temporal Arteries; Vasodilation | 1992 |
Massive ingestion of isosorbide-5-mononitrate and nitroglycerin: suicide attempt by an adolescent girl without previous heart disease.
Topics: Adolescent; Drug Overdose; Female; Humans; Isosorbide Dinitrate; Nitroglycerin; Suicide, Attempted; Tachycardia | 1992 |
Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.
Topics: Animals; Blood Pressure; Injections, Intravenous; Isosorbide Dinitrate; Male; Mathematics; Rats; Rats, Inbred Strains; Vasodilation | 1992 |
Investigation of a possible pharmacokinetic interaction between ibopamine and isosorbide-5-mononitrate.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Blood Pressure; Deoxyepinephrine; Drug Interactions; Female; Homovanillic Acid; Humans; Isosorbide Dinitrate; Male | 1992 |
Isosorbide mononitrate for angina.
Topics: Angina Pectoris; Clinical Trials as Topic; Humans; Isosorbide Dinitrate | 1992 |
Plasma profile and haemodynamic tolerance to isosorbide-5-mononitrate in controlled-release form.
Topics: Adult; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Half-Life; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 1992 |
Influence of standard and nicotine-reduced cigarette smoke on plasma concentrations of isosorbide dinitrate and its metabolites in rats.
Topics: Animals; Chromatography, Gas; Isosorbide Dinitrate; Male; Nicotine; Rats; Rats, Inbred Strains; Smoking | 1991 |
Fourth International Study of Infarct Survival: protocol for a large simple study of the effects of oral mononitrate, of oral captopril, and of intravenous magnesium. ISIS-4 collaborative group.
Topics: Administration, Oral; Captopril; Clinical Trials as Topic; Delayed-Action Preparations; Fibrinolytic Agents; Humans; Injections, Intravenous; Isosorbide Dinitrate; Magnesium; Multicenter Studies as Topic; Myocardial Infarction; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Thrombolytic Therapy | 1991 |
[Comparison of the clinical and hemodynamic effects of nitroglycerin, isosorbide dinitrate and isosorbide-5-mononitrate in acute myocardial infarction].
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Ventricular Function, Left | 1991 |
Evaluation of effectiveness and tolerability of isosorbide mononitrate during a three-year period in patients with angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Coronary Disease; Exercise Test; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Risk Factors | 1991 |
Slow release isosorbide-5-mononitrate therapy in angina pectoris. Effects of exercise performance and hemodynamics.
Topics: Aged; Angina Pectoris; Chronic Disease; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Exercise; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged | 1991 |
[Platelet aggregation with SIN 1: comparison with isosorbide-5-mononitrate and acetylsalicylic acid].
Topics: Aspirin; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1991 |
Gas chromatographic analysis of isomeric organic mononitrates in plasma.
Topics: Animals; Chromatography, Gas; Isomerism; Isosorbide Dinitrate; Nitrates; Rats | 1991 |
[Prognostic significance of disorders of regional left-ventricular contractility detected in the subacute period of myocardial infarction].
Topics: Adult; Cardiomyopathy, Dilated; Coronary Vessels; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Prognosis; Time Factors; Vasodilator Agents; Ventricular Function, Left | 1991 |
Chronopharmacology of oral nitrates in healthy subjects.
Topics: Administration, Oral; Adult; Blood Pressure; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1991 |
New methods for the assay of 5-isosorbide mononitrate and its validation.
Topics: Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dosage Forms; Isosorbide Dinitrate | 1991 |
[Bioavailability and bioequivalence of organic nitrates. Isosorbide dinitrate--a study of sustained-release preparations].
Topics: Adult; Delayed-Action Preparations; Half-Life; Humans; Isosorbide Dinitrate; Male; Therapeutic Equivalency | 1991 |
Mechanisms of nitrate-induced vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cysteine; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Vasodilation | 1990 |
The sorption of isosorbide-5-mononitrate to intravenous delivery systems.
Topics: Adsorption; Glucose; Hardness; Infusions, Intravenous; Isosorbide Dinitrate; Plasticizers; Polyvinyl Chloride; Rubber; Sodium Chloride; Solutions; Syringes | 1990 |
[Effectiveness of the delayed-action form of isosorbide 5-mononitrate in ischemic heart disease].
Topics: Coronary Disease; Delayed-Action Preparations; Hemodynamics; Humans; Isosorbide Dinitrate | 1991 |
Pharmacokinetics of oral isosorbide-5-mononitrate in patients with ischemic heart failure.
Topics: Absorption; Adult; Aged; Central Venous Pressure; Chromatography, Gas; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction | 1991 |
Clinical chronopharmacology of oral sustained-release isosorbide-5-mononitrate in healthy subjects.
Topics: Administration, Oral; Adult; Blood Pressure; Circadian Rhythm; Delayed-Action Preparations; Heart Rate; Humans; Isosorbide Dinitrate; Male | 1991 |
A symposium: Advances in nitrate therapy (Part 2). Montreux, Switzerland.
Topics: Heart Diseases; Humans; Isosorbide Dinitrate; Nitroglycerin | 1990 |
Assay of glyceryl trinitrate, isosorbide dinitrate, and their metabolites in plasma by large-bore capillary column gas-liquid chromatography.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Nitroglycerin | 1990 |
The effect of prenylamine and organic nitrates on the bioenergetics of bovine catecholamine storage vesicles.
Topics: Animals; Catecholamines; Cattle; Chromaffin Granules; Chromaffin System; Dopamine; Energy Metabolism; In Vitro Techniques; Isosorbide Dinitrate; Nitroglycerin; Prenylamine; Proton-Translocating ATPases | 1990 |
The evaluation of radioactive microsphere data: remarks on the use of the BMDP and SAS statistical software packages.
Topics: Algorithms; Analysis of Variance; Animals; Arterial Occlusive Diseases; Collateral Circulation; Computer Simulation; Data Interpretation, Statistical; Dogs; Hemodynamics; Isosorbide Dinitrate; Leg; Microspheres; Radionuclide Imaging; Regional Blood Flow; Research Design; Software; Tissue Distribution | 1990 |
Enhancement of portal pressure reduction by the association of isosorbide-5-mononitrate to propranolol administration in patients with cirrhosis.
Topics: Aged; Blood Pressure; Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Circulation; Liver Cirrhosis; Male; Middle Aged; Propranolol; Time Factors; Vascular Resistance | 1990 |
Determination of isosorbide-5-mononitrate in human serum by gas chromatography-mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Isosorbide Dinitrate; Kinetics; Quality Control | 1990 |
Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.
Topics: Animals; Electroshock; Foot; Injections, Intraperitoneal; Isosorbide Dinitrate; Male; Rats; Reference Values; Stress, Psychological | 1990 |
Concentrations of isosorbide dinitrate, isosorbide-2-mononitrate and isosorbide-5-mononitrate in human vascular and muscle tissue under steady-state conditions.
Topics: Aged; Chromatography, Gas; Humans; Isosorbide Dinitrate; Male; Middle Aged; Muscle, Smooth, Vascular; Muscles | 1990 |
Interval treatment of coronary artery disease with sustained-release isosorbide-5-mononitrate.
Topics: Adult; Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Drug Administration Schedule; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Pulmonary Wedge Pressure | 1990 |
Lack of tolerance after chronic administration of controlled-release isosorbide-5-mononitrate. Interaction of nitrate and gallopamil.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Delayed-Action Preparations; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Electrocardiography; Female; Gallopamil; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Radionuclide Ventriculography | 1990 |
Relationship between pharmacokinetics and hemodynamic tolerance to isosorbide-5-mononitrate.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Reference Values | 1990 |
Anti-ischemic and antianginal effects of 60 mg isosorbide-5-mononitrate in patients treated chronically after myocardial infarction.
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Exercise; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction | 1990 |
The effects of oral isosorbide 5-mononitrate on mortality following acute myocardial infarction.
Topics: Humans; Isosorbide Dinitrate; Myocardial Infarction; Research Design; Survival Rate | 1990 |
Cyclic GMP in nicorandil-induced vasodilatation and tolerance development.
Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1987 |
Mechanisms for the in vivo antiplatelet effects of isosorbide dinitrate.
Topics: Adult; Epoprostenol; Female; Humans; Iloprost; In Vitro Techniques; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboxane B2 | 1988 |
Effectiveness of interval nitrate therapy in angina pectoris.
Topics: Administration, Cutaneous; Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin | 1989 |
Effect of pertussis toxin and the cGMP lowering agent LY83583 on the relaxation induced by nitrates in isolated bovine mesenteric artery. A comparison between glyceryl trinitrate, isosorbide dinitrate and isosorbide 5-mononitrate.
Topics: Aminoquinolines; Animals; Cattle; Cyclic GMP; Isosorbide Dinitrate; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Pertussis Toxin; Vascular Resistance; Virulence Factors, Bordetella | 1989 |
Clinical chronopharmacology of oral nitrates.
Topics: Administration, Oral; Adult; Circadian Rhythm; Delayed-Action Preparations; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1989 |
[Use of isosorbide-5-mononitrate in acute myocardial infarction].
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction | 1989 |
A comparison of the haemodynamic effect of isosorbide-5-mononitrate and isosorbide dinitrate administered in intravenous injection to patients with acute myocardial infarction.
Topics: Aged; Female; Hemodynamics; Humans; Injections, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Stroke Volume; Vascular Resistance | 1989 |
[Determination of isosorbide dinitrate and its degradation products in pharmaceuticals by gradient RP-HPLC].
Topics: Chromatography, High Pressure Liquid; Isosorbide Dinitrate | 1989 |
Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Kidney Failure, Chronic; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged | 1989 |
Effects of a single dose of isosorbide-5-mononitrate on the left ventricular diastolic function in systemic hypertension.
Topics: Adult; Aged; Diastole; Female; Heart; Hemodynamics; Humans; Hypertension; Isosorbide Dinitrate; Lung; Male; Middle Aged; Radionuclide Imaging; Stroke Volume; Vasodilation | 1989 |
Determination of isosorbide-5-mononitrate in tablets by differential pulse polarography.
Topics: Indicators and Reagents; Isosorbide Dinitrate; Polarography; Tablets | 1989 |
Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate orally administered to rats.
Topics: Administration, Oral; Animals; Electroshock; Isosorbide Dinitrate; Male; Rats; Rats, Inbred Strains; Stress, Psychological | 1989 |
[Moniside (isosorbide-5-mononitrate)--the effect on some changes in a hyperlipoproteinemia mode in rats].
Topics: Animals; Hyperlipoproteinemias; Isosorbide Dinitrate; Male; Rats; Rats, Inbred Strains | 1989 |
Performance of a slow-release formulation of isosorbide-5-mononitrate (ISMO retard).
Topics: Adolescent; Adult; Biological Availability; Body Height; Body Weight; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Metabolic Clearance Rate | 1989 |
[Effects of isosorbide-5-mononitrate on exercise capacity, prostacyclin synthesis, the renin-aldosterone axis and catecholamines in patients with cardiac insufficiency].
Topics: Aged; Catecholamines; Female; Heart Failure; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Endurance; Prostaglandins F; Renin-Angiotensin System; Time Factors | 1989 |
New isosorbide 5-mononitrate derivative with hypotensive activity.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chemical Phenomena; Chemistry; Female; Guinea Pigs; In Vitro Techniques; Isosorbide Dinitrate; Male; Mice; Rabbits; Rats; Rats, Inbred Strains | 1989 |
Determination of isosorbide dinitrate and its metabolites in plasma by gas chromatography on a capillary column with electron-capture detection.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Reference Standards | 1989 |
Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate subcutaneously administered to rats.
Topics: Animals; Chromatography, Gas; Electroshock; Injections, Subcutaneous; Isosorbide Dinitrate; Male; Rats; Rats, Inbred Strains; Stress, Psychological; Temperature | 1989 |
[Hemodynamic effect of isosorbide-5-mononitrate in acute cardiac insufficiency secondary to myocardial infarct].
Topics: Acute Disease; Cardiac Output, Low; Drug Administration Schedule; Drug Evaluation; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardial Infarction | 1989 |
Dose-ranging study of isosorbide-5-mononitrate in chronic congestive heart failure treated with diuretics and angiotensin-converting enzyme inhibitor.
Topics: Aged; Blood Pressure; Cardiac Output; Chronic Disease; Diuretics; Drug Therapy, Combination; Enalapril; Female; Heart Failure; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Pulmonary Wedge Pressure | 1988 |
Influence of beta-blocker coadministration on the kinetics of isosorbide mononitrate and dinitrate.
Topics: Adrenergic beta-Antagonists; Adult; Drug Interactions; Female; Humans; Isosorbide Dinitrate; Male; Metipranolol; Metoprolol; Propranolol | 1986 |
Mechanism of vasodilation by nitrates: role of cyclic GMP.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilator Agents | 1987 |
Abrupt withdrawal of isosorbide 5-mononitrate (Imdur) after long term treatment in stable angina pectoris. A preliminary report.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Isosorbide Dinitrate; Middle Aged; Substance Withdrawal Syndrome | 1987 |
[Comparison of steady state pharmacokinetics of isosorbide-5-mononitrate in microgranular formulation or hydrophilic matrix].
Topics: Adult; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Male; Middle Aged; Models, Biological; Time Factors | 1988 |
Isosorbide 5-mononitrate effects on isolated rabbit aorta and vena cava: relationship between cyclic GMP and relaxation of vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Vena Cava, Inferior | 1985 |
Nitro compounds (isosorbide dinitrate, 5-isosorbide mononitrate and glyceryl trinitrate) on the femoral vein and femoral artery.
Topics: Animals; Dose-Response Relationship, Drug; Femoral Artery; Femoral Vein; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitroglycerin; Norepinephrine; Rabbits | 1986 |
In vitro evidence of an endothelial cell-dependent antiplatelet activity for isosorbide dinitrate, but not for its 2- and 5-mononitrate metabolites.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Cell Extracts; Cells, Cultured; Dinoprostone; Endothelium; Female; Humans; Isosorbide Dinitrate; Male; Platelet Aggregation; Prostaglandins E; Thromboxane B2; Tissue Extracts | 1987 |
Effects of nitro compounds, isosorbide dinitrate, 5-isosorbide mononitrate and glyceryl trinitrate on Ca-uptake into Ca-stores and Ca-release from Ca-stores in rabbit isolated femoral veins and femoral arteries.
Topics: Animals; Blood Vessels; Calcium; Femoral Artery; Femoral Vein; In Vitro Techniques; Isosorbide Dinitrate; Male; Nitro Compounds; Nitroglycerin; Rabbits; Vasodilator Agents | 1987 |
A symposium: Advances in clinical practice of nitrate therapy. March 31, 1987, Montreux, Switzerland. Proceedings.
Topics: Heart Diseases; Humans; Isosorbide Dinitrate; Nitroglycerin | 1988 |
Comparative evaluation of isosorbide-5-mononitrate and nitroglycerin in chronic congestive heart failure.
Topics: Aged; Blood Pressure; Female; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Nitroglycerin | 1988 |
Slow-release isosorbide-5-mononitrate--a new once daily therapeutic modality for angina pectoris.
Topics: Administration, Oral; Adult; Angina Pectoris; Delayed-Action Preparations; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Physical Exertion | 1988 |
When does nitrate tolerance develop? What dosages and which intervals are necessary to ensure maintained effectiveness?
Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Nitroglycerin; Random Allocation | 1988 |
Abrupt withdrawal of isosorbide-5-mononitrate in Durules (Imdur) after long term treatment in patients with stable angina pectoris.
Topics: Acute Disease; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Substance Withdrawal Syndrome | 1988 |
Influence of exercise on plasma concentrations of isosorbide dinitrate.
Topics: Administration, Oral; Adult; Female; Humans; Isosorbide Dinitrate; Male; Physical Exertion; Rest | 1988 |
Comparative pharmacokinetics of isosorbide nitrates after repeated doses of sustained release isosorbide dinitrate.
Topics: Adult; Delayed-Action Preparations; Female; Half-Life; Humans; Isosorbide Dinitrate; Male; Tablets | 1988 |
Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates.
Topics: Adult; Blood Platelets; Drug Synergism; Epoprostenol; Female; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Nitrates; Platelet Aggregation; Thromboxane B2 | 1988 |
Sustained-release isosorbide mononitrate (50 mg): optimization of a once-daily dosage form for long-term treatment of angina pectoris.
Topics: Adolescent; Adult; Angina Pectoris; Biological Availability; Delayed-Action Preparations; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Male; Tablets | 1988 |
Emergency treatment of severe cardiogenic pulmonary edema with intravenous isosorbide-5-mononitrate.
Topics: Acute Disease; Aged; Aged, 80 and over; Blood Pressure; Emergencies; Female; Heart Diseases; Humans; Infusions, Intravenous; Injections, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Pulmonary Edema; Respiration | 1988 |
The effect of food on the absorption of slow-release isosorbide-5-mononitrate tablets.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Biological Availability; Blood Pressure; Chromatography, Gas; Delayed-Action Preparations; Female; Food; Half-Life; Humans; Isosorbide Dinitrate; Male; Random Allocation; Regression Analysis; Tablets; Time Factors | 1988 |
Effect and mechanism of action of isosorbide-5-mononitrate.
Topics: Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Portal System | 1988 |
[Hemodynamic effects of isosorbide-5-mononitrate in ischemic cardiopathy].
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Female; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vascular Resistance | 1988 |
Dose-dependent relaxation of human venous vessel strips with regard to chronic nitrate pretreatment.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Humans; In Vitro Techniques; Isosorbide Dinitrate; Saphenous Vein; Vasodilation | 1988 |
Haemodynamic effects of intravenous isosorbide-5-mononitrate in acute and chronic left heart failure of ischaemic aetiology.
Topics: Aged; Blood Pressure; Cardiac Output; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Pulmonary Wedge Pressure | 1988 |
Control of the anti-thrombogenic endothelial cell defense by short- and long-term exposure of cultured endothelial cells to isosorbide nitrates.
Topics: Animals; Cattle; Endothelium, Vascular; Humans; In Vitro Techniques; Isosorbide Dinitrate; Platelet Adhesiveness; Platelet Aggregation; Time Factors | 1988 |
[Hemodynamic action of isosorbide-5-mononitrate during rapid venous administration in patients with acute myocardial infarct].
Topics: Adult; Aged; Cardiac Catheterization; Drug Evaluation; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Time Factors | 1988 |
[Concentration-time profile of isosorbide dinitrate and its metabolites in plasma following percutaneous resorption of a transdermal therapeutic system].
Topics: Administration, Cutaneous; Adult; Biological Availability; Female; Humans; Isosorbide Dinitrate; Male; Time Factors | 1987 |
[Pharmacokinetics and bioavailability of a new slow-release isosorbide-5-mononitrate system].
Topics: Adult; Biological Availability; Delayed-Action Preparations; Half-Life; Humans; Isosorbide Dinitrate; Male | 1987 |
[Evaluation of the therapeutic efficacy of slow-release isosorbide-5-mononitrate in ischemic cardiopathy].
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1987 |
[Ergometric evaluation of slow-release isosorbide-5-mononitrate in exertional angina with stable threshold].
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Exercise Test; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1987 |
[Clinical use of slow-release isosorbide-5-mononitrate in cardiac insufficiency].
Topics: Aged; Delayed-Action Preparations; Drug Evaluation; Exercise Test; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Random Allocation | 1987 |
Investigation of the gastrointestinal transit and in vivo drug release of isosorbide-5-nitrate pellets.
Topics: Delayed-Action Preparations; Digestive System; Gastrointestinal Transit; Humans; Isosorbide Dinitrate; Male; Radionuclide Imaging | 1987 |
Oral isosorbide-5-mononitrate: pharmacokinetics and clinical efficacy.
Topics: Administration, Oral; Coronary Disease; Drug Tolerance; Half-Life; Headache; Heart Failure; Humans; Isosorbide Dinitrate; Kidney Failure, Chronic; Kinetics; Liver Cirrhosis; Male | 1987 |
Pituitary apoplexy following isosorbide administration.
Topics: Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Pituitary Apoplexy | 1987 |
[Studies on isosorbide dinitrate. II. Determination of isosorbide 5-mononitrate in human plasma and pharmacokinetics].
Topics: Adult; Chromatography, Gas; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Tablets | 1987 |
Oral isosorbide 5-mononitrate can protect from myocardial ischemia induced by ergonovine test and by isometric effort. Preliminary results from an echocardiographic acute study in anginal patients.
Topics: Administration, Oral; Coronary Disease; Coronary Vasospasm; Echocardiography; Ergonovine; Humans; Isometric Contraction; Isosorbide Dinitrate | 1987 |
Isosorbide 5-mononitrate in the treatment of left ventricular failure following acute myocardial infarction.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Blood Pressure; Cardiac Output; Heart Failure; Heart Rate; Humans; Injections, Intravenous; Isosorbide Dinitrate; Middle Aged; Myocardial Infarction | 1987 |
Acute and chronic use of isosorbide 5-mononitrate in patients with heart failure.
Topics: Cardiomyopathy, Dilated; Coronary Disease; Digoxin; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged | 1987 |
Mononitrates as monotherapy in the prophylactic treatment of angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nitrates | 1987 |
Pharmacokinetics of isosorbide-5-nitrate during haemodialysis and peritoneal dialysis.
Topics: Adult; Aged; Aged, 80 and over; Female; Half-Life; Humans; Isosorbide Dinitrate; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1987 |
The efficacy of isosorbide-5-mononitrate on effort-induced electrocardiographic ischemic changes in patients with angina pectoris.
Topics: Angina Pectoris; Drug Evaluation; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Time Factors | 1987 |
Contribution of isosorbide-5-mononitrate, a major metabolite of isosorbide dinitrate (ISDN), to the hemodynamic effect of ISDN administered orally in conscious dogs.
Topics: Administration, Oral; Animals; Biotransformation; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Female; Isosorbide Dinitrate; Male; Pulse | 1987 |
Pharmacokinetics of isosorbide mononitrate in a new sustained release oral form in comparison with a conventional formulation.
Topics: Administration, Oral; Adult; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Male | 1987 |
Isosorbide-5-mononitrate in the treatment of acute left ventricular failure following acute myocardial infarction.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Female; Heart Failure; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Pulmonary Circulation; Time Factors | 1986 |
Effects of isosorbide-5-mononitrate on exercise-induced hemodynamic changes in angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Electrocardiography; Exercise Test; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Pulmonary Wedge Pressure; Vascular Resistance | 1986 |
Pharmacokinetics of isosorbide-5-nitrate in renal failure.
Topics: Aged; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Isosorbide Dinitrate; Kidney Failure, Chronic; Kinetics; Male; Middle Aged | 1986 |
Pharmacokinetics of isosorbide dinitrate and its mononitrate metabolites after intravenous infusion.
Topics: Adult; Aged; Female; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Models, Biological | 1986 |
[Effect of 50 mg isosorbide-5-nitrate retard on the stress tolerance of patients with coronary heart disease].
Topics: Adult; Coronary Disease; Delayed-Action Preparations; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1986 |
Dose-dependent effects of isosorbide-5-mononitrate on the venous, arterial and coronary arterial system of conscious dogs.
Topics: Animals; Arteries; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Isosorbide Dinitrate; Male; Vascular Resistance; Veins | 1986 |
[Influence of isosorbide-5-mononitrate on the tolerance test to exertion in angina pectoris].
Topics: Angina Pectoris; Double-Blind Method; Echocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Male | 1985 |
Characterization of vasodilators by comparison of their effects on blood pressure, counterregulation and myocardial oxygen demand in conscious normotensive dogs.
Topics: Animals; Blood Pressure; Dihydralazine; Dogs; Female; Heart Rate; Isosorbide Dinitrate; Labetalol; Male; Molsidomine; Myocardium; Oxygen Consumption; Piperazines; Prazosin; Pyridazines; Renin; Sydnones; Vasodilator Agents | 1985 |
The effect of isosorbide dinitrate and isosorbide-5-mononitrate on prostacyclin (PGI2) and thromboxane A2 (TXA2) generation in rat and human arteries.
Topics: Aged; Animals; Aorta, Thoracic; Blood Vessels; Coronary Vessels; Epoprostenol; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxanes; Vasodilator Agents | 1985 |
Nitrates and endothelial prostacyclin production: studies in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Blood Vessels; Cells, Cultured; Endothelium; Epoprostenol; Humans; In Vitro Techniques; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Thromboxane B2; Vasodilator Agents | 1985 |
[Value of nitrates in modern coronary therapy].
Topics: Angina Pectoris; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Hemodynamics; Humans; Isosorbide Dinitrate; Long-Term Care; Nitrates | 1985 |
Isosorbide-5-mononitrate--effective monotherapy in chronic stable angina.
Topics: Administration, Oral; Aged; Angina Pectoris; Chronic Disease; Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Physical Exertion | 1985 |
Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration.
Topics: Administration, Oral; Biological Availability; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Male; Models, Biological | 1985 |
[Comparative study of the bioavailability and pharmacokinetics of isosorbide dinitrate formulations in retard form and in standard preparations by determination of isosorbide-5-mononitrate].
Topics: Biological Availability; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Time Factors | 1985 |
Isosorbide dinitrate bioavailability, kinetics, and metabolism.
Topics: Administration, Oral; Adult; Biological Availability; Humans; Injections, Intravenous; Isosorbide Dinitrate; Kinetics; Male; Models, Biological; Mouth Floor; Tablets | 1985 |
[Isosorbide-5-mononitrate. A metabolite of isosorbide dinitrate].
Topics: Angina Pectoris; Humans; Isosorbide Dinitrate | 1985 |
Digital pulse plethysmography--a tool for investigating vasoactive substances.
Topics: Carbazoles; Carvedilol; Fingers; Humans; Indoles; Isosorbide Dinitrate; Plethysmography; Propanolamines; Pulse; Vasodilator Agents | 1985 |
[Effects of isosorbide 5-mononitrate on cardiovascular function. (II). Effects on pre-load and after-load].
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Female; Heart; Heart Rate; Hemodynamics; Injections, Intravenous; Isosorbide Dinitrate; Male; Propranolol; Time Factors; Verapamil | 1985 |
Gas-liquid chromatographic determination of isosorbide-5-mononitrate derivatized with perfluorinated anhydrides for pharmacokinetic and bioavailability investigations.
Topics: Biological Availability; Chromatography, Gas; Fluorocarbons; Humans; Isosorbide Dinitrate; Kinetics | 1985 |
[The duration of th effect of isosorbide-5-mononitrate--a new anti-anginal agent].
Topics: Coronary Disease; Hemodynamics; Humans; Isosorbide Dinitrate; Time Factors | 1985 |
Anti-anginal and anti-ischemic efficacy of conventional and slow release formulations of isosorbide-5-mononitrate in angina pectoris.
Topics: Angina Pectoris; Biological Availability; Coronary Disease; Delayed-Action Preparations; Humans; Isosorbide Dinitrate | 1985 |
[Effect of isosorbide-5-mononitrate, metipranolol and a combination of the two in experimental myocardial ischemia in the awake dog].
Topics: Adrenergic beta-Antagonists; Animals; Coronary Disease; Dogs; Drug Therapy, Combination; Isosorbide Dinitrate; Male; Metipranolol; Propanolamines | 1981 |
Pharmacokinetics of nitroglycerin and long-acting nitrate esters.
Topics: Absorption; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Kinetics; Nitrates; Nitroglycerin | 1983 |
In vivo and in vitro studies to elucidate the hemodynamic differences of sodium nitroprusside, nitroglycerin, and two isosorbide nitrates.
Topics: Animals; Blood Pressure; Ferricyanides; Hemodynamics; In Vitro Techniques; Isosorbide Dinitrate; Nitroglycerin; Nitroprusside; Rabbits; Rats; Rats, Inbred Strains; Renal Artery; Renal Veins | 1983 |
On the haemodynamic differences between sodium nitroprusside, nitroglycerin, and isosorbide nitrates. Comparison of their vasorelaxant effects in vitro and of their inactivation in vivo.
Topics: Animals; Blood Pressure; Female; Ferricyanides; Hemodynamics; In Vitro Techniques; Infusions, Intra-Arterial; Infusions, Parenteral; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Rabbits; Rats; Rats, Inbred Strains; Renal Artery; Renal Veins; Vasoconstriction; Vasodilation | 1984 |
[Long-term therapy with nitrates. Relation between dosage and tolerance effect].
Topics: Adult; Angina Pectoris; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate; Long-Term Care; Middle Aged; Nitroglycerin | 1984 |
Determination of the partitioning, stability, and metabolite formation of isosorbide dinitrate in human and rat blood using an improved gas-liquid chromatographic assay.
Topics: Animals; Chromatography, Gas; Drug Stability; Humans; Isosorbide Dinitrate; Kinetics; Male; Nitroglycerin; Rats; Rats, Inbred Strains; Solubility | 1984 |
Investigations into the development of tolerance to organic nitrates in conscious dogs.
Topics: Animals; Blood Pressure; Dogs; Drug Tolerance; Female; Hemodynamics; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Time Factors | 1984 |
Treatment of coronary heart disease with isosorbide mononitrate ('Elantan' 20): a multi-centre study in hospital and general practice.
Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin | 1984 |
Isosorbide 5-mononitrate and isosorbide 2-mononitrate kinetics after intravenous and oral dosing.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Female; Half-Life; Humans; Infusions, Parenteral; Injections, Intravenous; Isosorbide Dinitrate; Kinetics; Male | 1984 |
Determination of isosorbide 5-mononitrate in human plasma by capillary column gas chromatography.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate | 1984 |
Isosorbide dinitrate disposition in the rat: metabolite pharmacokinetics and interactions.
Topics: Animals; Half-Life; Isosorbide Dinitrate; Kinetics; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains | 1984 |
Effect of 5-isosorbide mononitrate on isosorbide dinitrate-induced relaxation of rabbit aortic rings.
Topics: Animals; Aorta; Dose-Response Relationship, Drug; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle Relaxation; Rabbits; Vasodilation | 1984 |
[Pharmacokinetics of isodinit (from Pharmachem) in humans].
Topics: Adult; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Tablets | 1984 |
The effect of food on the oral absorption of isosorbide-5-mononitrate.
Topics: Adult; Biological Availability; Female; Food; Half-Life; Humans; Intestinal Absorption; Isosorbide Dinitrate; Kinetics; Male | 1984 |
Metabolic fact of 14C-isosorbide 5-mononitrate in humans.
Topics: Adult; Biotransformation; Chromatography, Thin Layer; Humans; Isosorbide; Isosorbide Dinitrate; Male; Mass Spectrometry; Saliva; Time Factors | 1984 |
[Bioavailability of isosorbide-5-mononitrate from delayed-action formulations].
Topics: Biological Availability; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Kinetics; Male; Time Factors | 1984 |
[Elantan in coronary heart disease. Report of experiences].
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1983 |
Bioavailability of isosorbide dinitrate and its two mononitrate metabolites from sustained-release formulations.
Topics: Adolescent; Adult; Biological Availability; Delayed-Action Preparations; Half-Life; Humans; Isosorbide Dinitrate; Male | 1983 |
Newer aspects of the pharmacokinetics of organic nitrates.
Topics: Biological Availability; Humans; Isosorbide Dinitrate; Kinetics | 1983 |
Dose dependence of tolerance during treatment with mononitrates.
Topics: Adult; Blood Pressure; Coronary Disease; Dose-Response Relationship, Drug; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Physical Exertion | 1983 |
Pharmacokinetics of isosorbide-5-mononitrate after oral and intravenous administration in patients with liver cirrhosis: first results.
Topics: Administration, Oral; Adult; Female; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Liver Cirrhosis; Male; Middle Aged | 1983 |
Hemodynamic effects of isosorbide-5-mononitrate in acute and chronic treatment of coronary heart disease.
Topics: Aged; Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1983 |
Does isosorbide-5-mononitrate influence left ventricular relaxation?
Topics: Adult; Blood Pressure; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Contraction | 1983 |
Single administration of atenolol does not influence the kinetics of orally given isosorbide dinitrate.
Topics: Administration, Oral; Adult; Aged; Atenolol; Humans; Isosorbide Dinitrate; Kinetics | 1983 |
Oral absorption and disposition of isosorbide dinitrate and isosorbide mononitrates in man.
Topics: Administration, Oral; Adult; Female; Humans; Intestinal Absorption; Isosorbide Dinitrate; Kinetics; Male; Middle Aged | 1983 |
Pharmacokinetic aspects of isosorbide-5-mononitrate in dogs.
Topics: Administration, Oral; Animals; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Hemodynamics; Injections, Intravenous; Isosorbide Dinitrate; Kinetics; Male; Models, Biological | 1984 |
[Tolerance or hemodynamic adaptation during nitrate therapy].
Topics: Adaptation, Physiological; Angina Pectoris; Drug Tolerance; Hemodynamics; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1984 |
Determination of the two mononitrate metabolites of isosorbide dinitrate in human plasma and urine by gas chromatography with electron-capture detection.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Hydrolysis; Isosorbide Dinitrate; Male; Time Factors | 1984 |
Differences in the nitrite ion formation and the toxicological findings between isosorbide dinitrate and isosorbide-5-mononitrate.
Topics: Alkaline Phosphatase; Animals; Dogs; Female; Isosorbide Dinitrate; Male; Methemoglobin; Nitrites | 1984 |
Isosorbide 5-mononitrate kinetics.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Male; Random Allocation | 1984 |
Determination of isosorbide dinitrate and its mononitrate metabolites in human plasma using Extrelut purification and capillary column gas-liquid chromatography.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Kinetics | 1984 |
Electrocardiographic analysis of the effects of isosorbide-5-mononitrate on regional myocardial ischemia in conscious dogs.
Topics: Administration, Oral; Animals; Coronary Disease; Disease Models, Animal; Dogs; Electrocardiography; Exercise Test; Female; Injections, Intravenous; Isosorbide Dinitrate; Male; Time Factors | 1984 |
Saliva concentrations of isosorbide dinitrate, isosorbide 2-mononitrate and isosorbide 5-mononitrate.
Topics: Adult; Humans; Isosorbide Dinitrate; Male; Saliva | 1984 |
[Higher therapeutic safety of Mono-Nitrate. Report on the 3rd Mono-Nitrate Workshop of the Pharma-Schwarz Company, Monheim].
Topics: Animals; Coronary Disease; Delayed-Action Preparations; Dogs; Humans; Isosorbide Dinitrate | 1984 |
[Isosorbide mononitrate or dinitrate in coronary disease?].
Topics: Coronary Disease; Humans; Isosorbide Dinitrate | 1983 |
[Left ventricular function parameters following administration of isosorbide-5-mononitrate].
Topics: Coronary Disease; Echocardiography; Female; Heart Function Tests; Heart Ventricles; Humans; Isosorbide Dinitrate; Male; Middle Aged | 1983 |
[Comparative clinical evaluation of ISDN and 5-ISMN as exemplified by Mono Mack 20 mg/40 mg].
Topics: Animals; Coronary Disease; Dogs; Drug Evaluation; Half-Life; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardial Infarction; Rats | 1983 |
[Isosorbide-5-mononitrate. Hemodynamic studies during subchronic therapy].
Topics: Aged; Blood Pressure; Coronary Disease; Electrocardiography; Exercise Test; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Pulmonary Wedge Pressure; Time Factors | 1983 |
Plasma concentrations of isosorbide dinitrate and mononitrates after acute and chronic oral administration of isosorbide dinitrate in man.
Topics: Administration, Oral; Aged; Biotransformation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Time Factors | 1982 |
[Comparative pharmacokinetics and bioavailability of isosorbide dinitrate and its metabolites isosorbide 5- and 2-mononitrate from delayed-release preparations].
Topics: Adult; Biological Availability; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male | 1982 |
[Hemodynamic effects of a transdermal formulation of isosorbide dinitrate and its pharmacokinetics in conscious dogs].
Topics: Administration, Topical; Animals; Delayed-Action Preparations; Dogs; Female; Hemodynamics; Isosorbide Dinitrate; Kinetics; Skin Absorption | 1982 |
[Previous history and principles of the development of isosorbide-5-mononitrate (IS-5-MN)].
Topics: Angina Pectoris; Animals; Biotransformation; Humans; Isosorbide Dinitrate | 1981 |
[Pharmacodynamics, pharmacokinetics and metabolism of isosorbide nitrates in the awake dog].
Topics: Animals; Dogs; Hemodynamics; Isosorbide; Isosorbide Dinitrate | 1981 |
[Comparison of isosorbide dinitrate, isosorbide-5-mononitrate and sodium nitrite in isolated vascular preparations].
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Isosorbide Dinitrate; Nitrites; Sodium Nitrite; Vascular Resistance | 1981 |
[Nitrite and methemoglobin formation in dogs following oral isosorbide dinitrate, isosorbide-2-mononitrate and isosorbide-5-mononitrate].
Topics: Animals; Dogs; Female; Isosorbide Dinitrate; Male; Methemoglobin; Nitrites | 1981 |
[Changes in the mechanical and electrophysiological properties of isolated blood vessels as a result of isosorbide-5-mononitrate. A comparison with the effect of other organic nitrates].
Topics: Animals; Aorta, Thoracic; Isosorbide Dinitrate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitrates; Portal Vein; Rats | 1981 |
[Pharmacokinetics, effect and tolerance of isosorbide dinitrate and isosorbide-5-mononitrate in healthy persons].
Topics: Humans; Isosorbide; Isosorbide Dinitrate; Pulse | 1981 |
[Pharmacokinetics of isosorbide-5-mononitrate in patients with advanced renal failure].
Topics: Adult; Aged; Creatinine; Female; Humans; Isosorbide Dinitrate; Kidney Failure, Chronic; Kinetics; Male; Middle Aged | 1981 |
[Hemodynamic changes at rest and during stress following isosorbide-5-mononitrate therapy in patients with coronary disease].
Topics: Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1981 |
[Hemodynamic effects of isosorbide-5-mononitrate at rest and during exertion in patients with serious angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Physical Exertion | 1981 |
[Hemodynamic effect, effect duration and pharmacokinetics of 80 mg of isosorbide-5-mononitrate in acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Hemodynamics; Humans; Isosorbide; Isosorbide Dinitrate; Middle Aged; Myocardial Infarction | 1981 |
[Comparative invasive examination of the effect of isosorbide-5-mononitrate and isosorbide dinitrate in chronic coronary insufficiency].
Topics: Chronic Disease; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate | 1981 |
Pharmacokinetics of intravenous and oral isosorbide - 5 - mononitrate.
Topics: Administration, Oral; Adolescent; Adult; Female; Half-Life; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Male | 1981 |
In vivo effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Azo Compounds; Cholesterol, Dietary; Coloring Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Female; Gas Chromatography-Mass Spectrometry; Isosorbide Dinitrate; Lipids; Muscle Relaxation; Muscle, Smooth, Vascular; Pentaerythritol Tetranitrate; Rabbits; Staining and Labeling; Vasodilator Agents | 1995 |
[Clinical effect of nitrates (Olicard 40) and their influence on deforming of erythrocytes against the background of 24-hour catecholaminuria].
Topics: Adult; Aged; Catecholamines; Erythrocyte Deformability; Exercise Test; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nitric Oxide; Vasodilator Agents | 1994 |
Effects of an early treatment with lisinopril and isosorbide-5-mononitrate on hemodynamics and late ventricular remodelling in rats with 9-week myocardial infarction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Follow-Up Studies; Hemodynamics; Isosorbide Dinitrate; Lisinopril; Male; Myocardial Infarction; Organ Size; Rats; Vasodilator Agents; Ventricular Dysfunction, Left | 1995 |
Correction to drug facts and comparisons.
Topics: Administration, Oral; Humans; Isosorbide Dinitrate; Medication Errors; Vasodilator Agents | 1995 |
Impact of left ventricular unloading after late reperfusion of canine anterior myocardial infarction on remodeling and function using isosorbide-5-mononitrate.
Topics: Animals; Arrhythmias, Cardiac; Collagen; Dogs; Echocardiography; Female; Heart Aneurysm; Hemodynamics; Isosorbide Dinitrate; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Time Factors; Vasodilator Agents; Ventricular Function, Left | 1995 |
The plasma concentrations of isosorbide 5-mononitrate (5-ISMN) administered in an extended-release form to patients with acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Vasodilator Agents | 1995 |
Gas chromatographic-mass spectrometric determination of isosorbide 5-mononitrate in human plasma.
Topics: Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Isosorbide Dinitrate; Male; Microchemistry; Quality Control; Reproducibility of Results; Sensitivity and Specificity | 1995 |
Effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate in experimental atherosclerosis.
Topics: Animals; Arteriosclerosis; Cholesterol; Diet, Atherogenic; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Isosorbide Dinitrate; Nitric Oxide; Pentaerythritol Tetranitrate; Rabbits; Vasodilation | 1995 |
The rationale for nitrates in angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Nitrates; Nitroglycerin; Patient Compliance; Vasodilator Agents | 1995 |
Absorption of isosorbide-5-mononitrate at specific sites in the gastrointestinal tract.
Topics: Administration, Oral; Adult; Biological Availability; Colon; Delayed-Action Preparations; Humans; Ileum; Intestinal Absorption; Intubation, Gastrointestinal; Isosorbide Dinitrate; Jejunum; Male; Vasodilator Agents | 1994 |
Effect of food on the oral bioavailability of isosorbide-5-mononitrate administered as an extended-release tablet.
Topics: Administration, Oral; Adult; Biological Availability; Delayed-Action Preparations; Food-Drug Interactions; Gastric Emptying; Humans; Isosorbide Dinitrate; Male; Monitoring, Physiologic | 1995 |
Nitrate tolerance.
Topics: Administration, Cutaneous; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Vasodilator Agents | 1995 |
Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester.
Topics: Acid Phosphatase; Animals; Arginine; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; Intestinal Mucosa; Isosorbide Dinitrate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Isosorbide 5-mononitrate reverses high blood pressure in NG-nitro-L-arginine methyl ester treated rats.
Topics: Animals; Arginine; Blood Pressure; Brain; Dopamine; Drinking; Drug Interactions; Epinephrine; Heart Rate; Hypertension; Isosorbide Dinitrate; Male; Methoxyhydroxyphenylglycol; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Wistar; Sympathetic Nervous System; Tissue Distribution; Vasodilator Agents | 1994 |
Drugs for stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Humans; Isosorbide Dinitrate; Nitroglycerin; Vasodilator Agents | 1994 |
[The efficacy of 2 new drug forms of isosorbide-5-mononitrate in patients with stable stenocardia of effort].
Topics: Adult; Angina Pectoris; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Middle Aged; Physical Exertion; Time Factors; Vasodilator Agents | 1994 |
[Gas chromatographic method with EC detection to determine isosorbide-5-mononitrate (IS-5-MN) in human serum and its pharmacokinetic parameters].
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 1994 |
Eccentric dosing and exercise time.
Topics: Angina Pectoris; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1994 |
The antianginal effect of isosorbide mononitrate.
Topics: Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1994 |
The acute and chronic effects of isosorbide-5-mononitrate on portal haemodynamics in cirrhosis.
Topics: Adult; Aged; Azygos Vein; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Middle Aged; Vasodilator Agents | 1994 |
Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate.
Topics: Aldehyde Dehydrogenase; Chloral Hydrate; Enzyme Reactivators; Esterases; Humans; Isoenzymes; Isosorbide Dinitrate; Mercaptoethanol; NAD; Oxidoreductases | 1994 |
Isosorbide-5-mononitrate in angina pectoris.
Topics: Angina Pectoris; Drug Administration Schedule; Humans; Isosorbide Dinitrate; Vasodilator Agents | 1994 |
Influence of endothelium and nitrovasodilators on free thiols and disulfides in porcine coronary smooth muscle.
Topics: Analysis of Variance; Animals; Coronary Vessels; Cysteine; Disulfides; Drug Tolerance; Endothelium, Vascular; Histocytochemistry; In Vitro Techniques; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Sulfhydryl Compounds; Swine; Vasodilator Agents | 1993 |
Pulmonary function tests in patients with congestive heart failure: effects of medical therapy.
Topics: Adult; Aged; Captopril; Cardiovascular Agents; Digoxin; Dobutamine; Drug Therapy, Combination; Echocardiography, Doppler; Forced Expiratory Volume; Furosemide; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Nitroprusside; Vasodilator Agents; Vital Capacity | 1993 |
Extended-release isosorbide mononitrate for angina.
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Drug Tolerance; Humans; Isosorbide Dinitrate | 1994 |
[Hemodynamic and functional hepatic effects of isosorbide-5-monitrate in cirrhotic patients with portal hypertension].
Topics: Adult; Aged; Female; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver; Liver Cirrhosis, Alcoholic; Male; Middle Aged | 1993 |
Nitric oxide and castor oil-induced diarrhea.
Topics: Animals; Arginine; Body Fluids; Castor Oil; Diarrhea; Electrolytes; Gastrointestinal Motility; Intestine, Small; Isosorbide Dinitrate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar | 1994 |
Release of nitric oxide from glyceryl trinitrate by captopril but not enalaprilat: in vitro and in vivo studies.
Topics: Acetylcysteine; Animals; Captopril; Cattle; Enalapril; Endothelium, Vascular; Glutathione; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Effects of nitric oxide-containing compounds on increases in cytosolic ionized Ca2+ and on aggregation of human platelets.
Topics: Calcium; Cytosol; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Niacinamide; Nicorandil; Nitric Oxide; Platelet Aggregation; Sydnones | 1993 |
Pharmacokinetics of stereomeric 1,4:3,6-dianhydrohexitol mononitrates in rats.
Topics: Animals; Injections, Intravenous; Isosorbide Dinitrate; Male; Nitrates; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sugar Alcohols; Vasodilator Agents | 1993 |
[Plasma levels of isosorbide dinitrate and its metabolites during intravenous infusion in surgical patients--effect of preoperative administration of isosorbide dinitrate].
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Neuroleptanalgesia; Preanesthetic Medication; Surgical Procedures, Operative | 1993 |
Renal effects of acute isosorbide-5-mononitrate administration in cirrhosis.
Topics: Aldosterone; Ascites; Atrial Natriuretic Factor; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Renin | 1993 |
[The use of oral and intravenous isosorbide mononitrate (5-MNi) in the acute phase of myocardial infarction].
Topics: Administration, Oral; Aged; Aged, 80 and over; Female; Hemodynamics; Humans; Injections, Intravenous; Isosorbide Dinitrate; Male; Myocardial Infarction; Vasodilator Agents | 1993 |
Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate.
Topics: Animals; Carcinoma; Cattle; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Male; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Nitric Oxide; Rabbits; Vasodilator Agents | 1995 |
[Acute effect of isosorbide mononitrate on blood circulation and myocardial ischemia in patients with atherosclerosis].
Topics: Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Vasodilator Agents; Ventricular Function, Left | 1995 |
Isosorbide 5 mononitrate administration increases nitric oxide blood levels and reduces proteinuria in IgA glomerulonephritis patients with abnormal urinary endothelin/cyclic GMP ratio.
Topics: Adult; Blood Pressure; Cyclic GMP; Electron Spin Resonance Spectroscopy; Endothelins; Female; Glomerulonephritis, IGA; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Proteinuria; Vasodilator Agents | 1995 |
Low increase in cGMP induced by organic nitrates and nitrovasodilators improves contractile response of rat ventricular myocytes.
Topics: Animals; Cells, Cultured; Cyclic GMP; Electric Stimulation; Heart Ventricles; Hydrazines; Isosorbide Dinitrate; Male; Myocardial Contraction; Nitrogen Oxides; Nitroglycerin; Penicillamine; Pentaerythritol Tetranitrate; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1996 |
Long-term administration of isosorbide-5-mononitrate does not impair renal function in cirrhotic patients.
Topics: Ascites; Atrial Natriuretic Factor; Blood Pressure; Drug Administration Schedule; Female; Glomerular Filtration Rate; Humans; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Potassium; Renal Plasma Flow; Renin; Vasodilator Agents | 1996 |
Nitrate tolerance--problems both new and old.
Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Heart Failure; Humans; Injections, Intravenous; Isosorbide Dinitrate; Myocardial Ischemia; Nitroglycerin; Vasodilator Agents | 1996 |
Resolution of rate-related left bundle branch block after nitrate therapy.
Topics: Bundle-Branch Block; Coronary Disease; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Isosorbide Dinitrate; Middle Aged; Valsalva Maneuver; Vasodilator Agents | 1996 |
Prevention of variceal rebleeding.
Topics: Acute Disease; Adrenergic beta-Antagonists; Diuretics, Osmotic; Drug Combinations; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Nadolol; Randomized Controlled Trials as Topic; Recurrence; Reproducibility of Results; Sclerotherapy; Treatment Outcome | 1996 |
Effect of isosorbiddinitrate on exogenously expressed slowly activating K+ channels and endogenous K+ channels in Xenopus oocytes.
Topics: Aminoquinolines; Animals; Barium; Cysteine; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Isosorbide Dinitrate; Kinetics; Oocytes; Patch-Clamp Techniques; Potassium Channels; Rats; RNA, Complementary; S-Nitrosothiols; Vasodilator Agents; Xenopus laevis | 1996 |
Surgery for left main spasm. Is it indicated?
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiac Surgical Procedures; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Felodipine; Humans; Isosorbide Dinitrate; Male; Nitroglycerin; Vasodilator Agents | 1996 |
[Evaluation of changes in pulmonary vein compliance in prognosis of clinical results after mitral valve replacement].
Topics: Cardiac Catheterization; Compliance; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Mitral Valve; Mitral Valve Stenosis; Prognosis; Pulmonary Veins; Vasodilator Agents | 1995 |
Improved extraction procedure for the assay of isosorbide-5-mononitrate in serum.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Reference Standards; Reproducibility of Results; Vasodilator Agents | 1996 |
Effects of varying doses of spironolactone without and with nitrates on portal vein pressure and kidney function in partial portal vein ligated rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Isosorbide Dinitrate; Kidney; Male; Plasma Volume; Portal Vein; Potassium; Rats; Rats, Wistar; Sodium; Spironolactone; Vasodilator Agents | 1996 |
Twenty-four hour plasma profile of sustained-release isosorbide mononitrate in healthy volunteers and in patients with chronic stable angina. Two open label trials.
Topics: Adult; Angina Pectoris; Blood Pressure; Delayed-Action Preparations; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 1997 |
Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage.
Topics: Antihypertensive Agents; Drug Therapy, Combination; Hemorrhage; Humans; Isosorbide Dinitrate; Nadolol; Prospective Studies; Randomized Controlled Trials as Topic; Sclerotherapy; Varicose Veins; Vasodilator Agents | 1997 |
Comments on 'A comparison of nifedipine once daily (Adalat LA), isosorbide mononitrate once daily and isosorbide dinitrate twice daily in patients with stable angina'.
Topics: Angina Pectoris; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nifedipine; Vasodilator Agents | 1997 |
[The anti-anginal efficacy of the drug forms of isosorbide-5-mononitrate--Monocinque, Monocinque retard and isosorbide dinitrate].
Topics: Angina Pectoris; Drug Evaluation; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Physical Exertion; Vasodilator Agents | 1997 |
Increased cardiac workload by adrenoceptor agonists for the estimation of potential antiischemic activity in a conscious rabbit model.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Disease Models, Animal; Electrophysiology; Heart; Hemodynamics; Injections, Intravenous; Isoproterenol; Isosorbide Dinitrate; Male; Myocardial Contraction; Myocardial Ischemia; Phenylephrine; Rabbits; Tachycardia; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Cost analysis of once-daily ISMN versus twice-daily ISMN or transdermal patch for nitrate prophylaxis.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Administration Schedule; Drug Costs; Exercise; Humans; Isosorbide Dinitrate; Middle Aged; Models, Statistical; United Kingdom; Vasodilator Agents | 1997 |
Validation of a telemetry system for measurement of blood pressure, electrocardiogram and locomotor activity in beagle dogs.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Delayed-Action Preparations; Dogs; Electrocardiography; Enzyme Inhibitors; Heart Rate; Isosorbide Dinitrate; Male; Molsidomine; Motor Activity; NG-Nitroarginine Methyl Ester; Ouabain; Reproducibility of Results; Telemetry; Vasodilator Agents | 1997 |
Effect of organic nitrates on ex vivo platelet aggregation and fibrinolysis in man.
Topics: Adenosine Diphosphate; Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Fibrinolysis; Heart Rate; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Nitroglycerin; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Tissue Plasminogen Activator; Vasodilator Agents | 1996 |
[The effect on painful and silent myocardial ischemia of the preparations Efox and Efox Long in patients with stenocardia of effort].
Topics: Angina Pectoris; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Physical Exertion; Time Factors; Vasodilator Agents | 1997 |
[An experimental study of lipid peroxidation processes and antioxidant protection in exposure to isosorbide-5-nitrate].
Topics: Animals; Antioxidants; Catalase; Female; Homeostasis; Isosorbide Dinitrate; Lipid Peroxidation; Luminescent Measurements; Malondialdehyde; Peroxidases; Rats; Vasodilator Agents | 1998 |
Calcium-activated potassium channels and nitrate-induced vasodilation in human coronary arteries.
Topics: Coronary Vessels; Heart; Humans; Hydrazines; Isosorbide Dinitrate; Mutagens; Myocardial Contraction; Nitrates; Nitrogen Oxides; Nitroprusside; Potassium Channels; Vasodilation; Vasodilator Agents | 1998 |
Acute effect of propranolol and isosorbide-5-mononitrate administration on renal blood flow in cirrhotic patients.
Topics: Adult; Aged; Azygos Vein; Blood Pressure; Drug Therapy, Combination; Female; Heart Rate; Hepatic Veins; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propranolol; Regional Blood Flow; Renal Circulation; Vasodilator Agents | 1998 |
Gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations.
Topics: Drug Contamination; Gas Chromatography-Mass Spectrometry; Isosorbide Dinitrate; Regression Analysis | 1997 |
[Sublingual isosorbide-5 mononitrate during coronary arteriography. Comparison with sublingual nitroglycerin].
Topics: Administration, Sublingual; Blood Pressure; Cardiac Catheterization; Cineangiography; Coronary Vessels; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Vasodilator Agents | 1997 |
[Time-dependent hemodynamic effects of monosan (Isosorbide-5-mononitrate) in anginal patients].
Topics: Angina Pectoris; Circadian Rhythm; Delayed-Action Preparations; Female; Follow-Up Studies; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Time Factors; Vasodilator Agents | 1998 |
Impairment of endothelium-dependent vasorelaxation in experimental atherosclerosis is dependent on gender.
Topics: Acetylcholine; Animals; Aorta; Arteriosclerosis; Cholesterol, Dietary; Endothelium, Vascular; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Penicillamine; Pentaerythritol Tetranitrate; Rabbits; Sex Factors; Vasodilation; Vasodilator Agents | 1998 |
Clinical vs haemodynamic response to drugs in portal hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Esophageal and Gastric Varices; Female; Follow-Up Studies; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Octreotide; Propranolol; Recurrence; Sclerotherapy; Time Factors; Treatment Outcome; Vasodilator Agents | 1998 |
Cardiovascular effects of dietary salts and isosorbide-5-mononitrate in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cations; Condiments; Delayed-Action Preparations; Heart Rate; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular; Isosorbide Dinitrate; Kidney; Male; Mesenteric Arteries; Rats; Rats, Inbred SHR; Salts; Sodium, Dietary; Vasodilator Agents | 1998 |
[Toxicological characteristics and bases of maximum allowable concentration of isosorbide-5-nitrate in the workplace air].
Topics: Air Pollutants, Occupational; Animals; Female; Fetus; Isosorbide Dinitrate; Lethal Dose 50; Male; Maximum Allowable Concentration; Nitric Oxide Donors; Pregnancy; Rats | 1998 |
Transdermal delivery of isosorbide 5-mononitrate from a new membrane reservoir and matrix-type patches.
Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Diffusion; Drug Delivery Systems; Humans; In Vitro Techniques; Isosorbide Dinitrate; Membranes, Artificial; Permeability; Rats; Skin; Vasodilator Agents | 1998 |
Matrix metalloproteinases-2 and -9 and their inhibitors are produced by the human uterine cervix but their secretion is not regulated by nitric oxide donors.
Topics: Cells, Cultured; Cervix Uteri; Collagenases; Culture Media, Conditioned; Female; Fibroblasts; Gelatinases; Humans; Isosorbide Dinitrate; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Nitric Oxide Donors; Pregnancy; Tissue Inhibitor of Metalloproteinases | 1999 |
[The evaluation of the bioavailability of isosorbide 5-mononitrate].
Topics: Adult; Biological Availability; Female; Humans; Isosorbide Dinitrate; Male; Propranolol; Vasodilator Agents | 1999 |
Effect of chronic treatment with nadolol plus isosorbide mononitrate on liver blood flow and liver metabolic activity in cirrhosis.
Topics: Adrenergic beta-Antagonists; Coloring Agents; Delayed-Action Preparations; Drug Therapy, Combination; Female; Hepatic Veins; Humans; Indocyanine Green; Isosorbide Dinitrate; Liver; Liver Circulation; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Nadolol; Nitric Oxide Donors; Venous Pressure | 1999 |
Nitric oxide generation, tachyphylaxis and cross-tachyphylaxis from nitrovasodilators in vivo.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Isosorbide Dinitrate; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Rabbits; Tachyphylaxis; Vasodilator Agents | 1999 |
Inhibition of nitric oxide synthase induces renal xanthine oxidoreductase activity in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Isosorbide Dinitrate; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Xanthine Dehydrogenase; Xanthine Oxidase | 1999 |
[Antianginal effectiveness of regular isosorbide-5-mononitrate (monochinkwe retard) intake].
Topics: Adult; Aged; Angina, Unstable; Delayed-Action Preparations; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Time Factors; Treatment Outcome; Vasodilator Agents | 1999 |
K-Cl cotransport in vascular smooth muscle and erythrocytes: possible implication in vasodilation.
Topics: Alkaloids; Animals; Aorta; Biological Transport; Carbazoles; Carrier Proteins; Cells, Cultured; Chlorides; Coronary Vessels; Enzyme Inhibitors; Erythrocytes; Ethylmaleimide; Genistein; Hydralazine; Indoles; Isometric Contraction; Isosorbide Dinitrate; K Cl- Cotransporters; Marine Toxins; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Oxazoles; Potassium; Propylene Glycols; Rats; Rubidium; Sheep; Swine; Symporters; Vasoconstriction; Vasodilation; Vasodilator Agents | 2000 |
Effectiveness of modified release isosorbide mononitrate affected by incorrect use.
Topics: Aged; Angina Pectoris; Chest Pain; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 2000 |
NO and de novo mammalian angiogenesis: further evidence that NO inhibits bFGF-induced angiogenesis while not influencing VEGF165-induced angiogenesis.
Topics: Animals; Endothelial Growth Factors; Enzyme Inhibitors; Fibroblast Growth Factor 2; Isosorbide Dinitrate; Lymphokines; Male; Microcirculation; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
[Cardiological use of mononitrates].
Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Electrocardiography, Ambulatory; Heart Diseases; Humans; Isosorbide Dinitrate; Time Factors; Vasodilator Agents | 2000 |
Isosorbide-5-mononitrate in the treatment of pulmonary hypertension associated with portal hypertension.
Topics: Female; Humans; Hypertension, Portal; Hypertension, Pulmonary; Isosorbide Dinitrate; Middle Aged; Vasodilator Agents | 1999 |
Packed-column supercritical fluid chromatography for the analysis of isosorbide-5-mononitrate and related compounds in bulk substance and tablets.
Topics: Chromatography; Chromatography, Liquid; Ions; Isosorbide Dinitrate; Nitrates; Sulfates; Tablets; Temperature; Time Factors | 2000 |
Reversal of heart failure remodeling in women.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Echocardiography; Female; Follow-Up Studies; Heart Failure; Humans; Isosorbide Dinitrate; Lisinopril; Male; Middle Aged; Prospective Studies; Retrospective Studies; Sex Factors; Treatment Outcome; Vasodilator Agents; Ventricular Remodeling | 2000 |
[Influence of nitrates on red blood cell deformability and clinical parameters in patients with silent ischemia].
Topics: Adult; Aged; Coronary Vessels; Erythrocytes; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Treatment Outcome; Vasodilator Agents | 1997 |
The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Drug Therapy, Combination; Esophageal and Gastric Varices; Female; Hemodynamics; Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Nadolol; Prognosis; Vasodilator Agents | 2000 |
Acute and chronic effects of isosorbide-5-mononitrate administration on effective renal plasma flow and the renin-aldosterone system in cirrhotic patients.
Topics: Adult; Aged; Female; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Renal Plasma Flow; Renin-Angiotensin System; Risk Factors; Vasodilator Agents | 2000 |
Influence of nitrovasodilators and cyclooxygenase inhibitors on cerebral vasoreactivity in conscious rabbits.
Topics: Acetazolamide; Animals; Blood Pressure; Blood Vessels; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Hypercapnia; Indomethacin; Isosorbide Dinitrate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Rabbits; Signal Transduction; Telencephalon; Vasodilation | 2001 |
Intermittent nitrate therapy for prior myocardial infaraction does not induce rebound angina nor reduce cardiac events.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Angina Pectoris; Cardiovascular Agents; Coronary Vasospasm; Delayed-Action Preparations; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Exercise Tolerance; Female; Follow-Up Studies; Heart Failure; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Recurrence; Retrospective Studies; Treatment Outcome | 2000 |
Central retinal vein occlusion associated with primary pulmonary hypertension.
Topics: Adult; Anticoagulants; Female; Fluorescein Angiography; Humans; Hypertension, Pulmonary; Isosorbide Dinitrate; Retinal Vein Occlusion; Vasodilator Agents; Visual Acuity; Warfarin | 2001 |
[Comparative study of retard and non-retard forms of isosorbide-5-mononitrate in coronary patients with stable angina pectoris].
Topics: Administration, Oral; Aged; Angina Pectoris; Delayed-Action Preparations; Electrocardiography; Exercise Tolerance; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Treatment Outcome; Vasodilator Agents | 2000 |
Pharmacokinetics of sustained-release capsule of 5-isosorbide mononitrate in 20 healthy Chinese young men.
Topics: Adult; Biological Availability; Chromatography, Gas; Cross-Over Studies; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Male; Random Allocation; Vasodilator Agents | 1999 |
Echocardiographical demonstration of a progressively expanding left ventricular aneurysm preceded by endomyocardial tearing.
Topics: Aged; Aneurysm, False; Antihypertensive Agents; Combined Modality Therapy; Coronary Disease; Disease Progression; Echocardiography; Endocardium; Female; Fibrin Tissue Adhesive; Heart Aneurysm; Heart Rupture; Heart Ventricles; Humans; Hypromellose Derivatives; Isosorbide Dinitrate; Methylcellulose; Myocardial Infarction; Nitroglycerin; Pericardial Effusion; Stroke Volume; Tissue Adhesives; Ventricular Remodeling | 2001 |
[Isosorbide-5-mononitrate (mono mac) in the prevention of bleeding from esophageal varicose veins in patients with liver cirrhosis].
Topics: Adrenergic beta-Antagonists; Blood Pressure; Drug Therapy, Combination; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Treatment Outcome; Vasodilator Agents | 2001 |
A validated gas chromatographic method for the determination of isosorbide-5-mononitrate in human plasma and its application to pharmacokinetic studies.
Topics: Calibration; Chromatography, Gas; Humans; Indicators and Reagents; Isosorbide Dinitrate; Reproducibility of Results; Therapeutic Equivalency; Vasodilator Agents | 2001 |
Somatostatin plus isosorbide mononitrate versus somatostatin in the control of acute gastro-oesophageal variceal bleeding: a double blind, randomised, placebo controlled trial.
Topics: Double-Blind Method; Drug Therapy, Combination; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hormones; Humans; Isosorbide Dinitrate; Middle Aged; Randomized Controlled Trials as Topic; Somatostatin; Vasodilator Agents | 2001 |
[Evaluation of the efficacy of isosorbide-5-mononitrate in CHF patients unresponsive to isosorbide dinitrate therapy].
Topics: Drug Resistance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome | 2001 |
Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from pressure-sensitive adhesive tape.
Topics: Adhesives; Animals; Calorimetry, Differential Scanning; Delayed-Action Preparations; Isosorbide Dinitrate; Male; Permeability; Pressure; Rats; Skin; Solubility | 2001 |
Efficiency of NO donors in substituting impaired endogenous NO production: a functional and morphological study.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Enzyme Activation; Enzyme Inhibitors; Hypertension; Isosorbide Dinitrate; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Wistar; Vasodilator Agents | 2001 |
Synthesis, hydrolysis kinetics and anti-platelet effects of isosorbide mononitrate derivatives of aspirin.
Topics: Animals; Aspirin; Blood; Hydrolysis; Isosorbide Dinitrate; Nitric Oxide Donors; Platelet Aggregation Inhibitors; Rabbits | 2001 |
[Determination of isosorbide-5-mononitrate in plasma by GC-ECD and study on its pharmacokinetics in ten volunteers].
Topics: Adult; Chromatography, Gas; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Male; Vasodilator Agents | 1997 |
[Mono Mac 50D treatment results in patients with chronic coronary heart disease].
Topics: Chronic Disease; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Vasodilator Agents | 2001 |
Chronic long-term nitrate therapy: possible cytogenetic effect in humans?
Topics: Case-Control Studies; Chromosome Aberrations; Cytogenetic Analysis; DNA Damage; Female; Humans; Isosorbide Dinitrate; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Middle Aged; Nitroprusside; Polymorphism, Single Nucleotide; Vasodilator Agents | 2001 |
Impact of reference-based pricing of nitrates on the use and costs of anti-anginal drugs.
Topics: Aged; Angina Pectoris; British Columbia; Cost Control; Cost Savings; Drug Costs; Drug Prescriptions; Economics, Pharmaceutical; Formularies as Topic; Health Policy; Humans; Isosorbide Dinitrate; Nitroglycerin; Prescription Fees; Rate Setting and Review; Vasodilator Agents | 2001 |
Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Fibrillation; Dogs; Electrophysiology; Enalapril; Endomyocardial Fibrosis; Heart Atria; Heart Failure; Hemodynamics; Hydralazine; Isosorbide Dinitrate; Mitogen-Activated Protein Kinases; Renin-Angiotensin System; Signal Transduction; Tachycardia, Ventricular | 2001 |
The prescription pattern of oral nitrates in coronary artery disease. Appropriateness and cost considerations.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Coronary Artery Disease; Costs and Cost Analysis; Delayed-Action Preparations; Drug Prescriptions; Drug Utilization; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Practice Patterns, Physicians'; Vasodilator Agents | 2001 |
Tolerance to nitroglycerin induced by isosorbide-5-mononitrate infusion in vivo.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Tolerance; Infusion Pumps, Implantable; Isosorbide Dinitrate; Male; Nitroglycerin; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2001 |
[Administration of various dosages of retard isosorbide-5-mononitrate in patients with stable angina pectoris on combined therapy].
Topics: Adult; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 2002 |
Massive choroidal hemorrhage associated with low molecular weight heparin therapy.
Topics: Acetazolamide; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Choroid Hemorrhage; Drug Therapy, Combination; Enoxaparin; Female; Furosemide; Glaucoma, Angle-Closure; Humans; Isosorbide Dinitrate; Retinal Detachment | 2002 |
Direct injection of aqueous samples in packed column supercritical fluid chromatography of isosorbide-5-mononitrate from drug release testing.
Topics: Chromatography; Isosorbide Dinitrate; Technology, Pharmaceutical; Vasodilator Agents | 2002 |
[Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding].
Topics: Drug Therapy, Combination; Esophageal and Gastric Varices; Esophagoscopy; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Nadolol; Randomized Controlled Trials as Topic; Recurrence | 2002 |
Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery.
Topics: Animals; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Mesenteric Artery, Superior; Muscle Relaxation; Muscle, Smooth, Vascular; Oximes; Rats; Vasodilator Agents | 2002 |
Pharmacologic efficacy in gastric variceal rebleeding and survival: including multivariate analysis.
Topics: Adrenergic beta-Antagonists; Carcinoma, Hepatocellular; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Portal Vein; Prognosis; Propranolol; Retrospective Studies; Risk Factors; Secondary Prevention; Survival Analysis; Venous Thrombosis | 2002 |
Combined therapy for secondary prophylaxis of variceal rebleeding?
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Endoscopy; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Isosorbide Dinitrate; Ligation; Nadolol; Postoperative Complications; Randomized Controlled Trials as Topic; Recurrence; Survival Analysis; Vasodilator Agents | 2002 |
Power of experimental design studies for the validation of pharmaceutical processes: case study of a multilayer tablet manufacturing process.
Topics: Chemistry, Pharmaceutical; Drug Industry; Isosorbide Dinitrate; Research Design; Tablets | 2002 |
[Effect of isosorbide mononitrate on hypotensive action of enalapril in patients with mild and moderate hypertension].
Topics: Administration, Oral; Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Renin; Severity of Illness Index; Time Factors; Treatment Outcome | 2002 |
A validated high performance liquid chromatographic method for analysis of isosorbide mononitrate in bulk material and extended release formulations.
Topics: Chromatography, High Pressure Liquid; Delayed-Action Preparations; Isosorbide Dinitrate | 2002 |
[Antianginal and anti-ischemic effects of Mono Mac 50D preparation as an agent in combined treatment of patients with stable angina].
Topics: Angina Pectoris; Delayed-Action Preparations; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Time Factors; Vasodilator Agents | 2002 |
[How is antianginal therapy with pentaerythritol tetranitrate executed?].
Topics: Angina Pectoris; Animals; Delayed-Action Preparations; Drug Administration Schedule; Heart Diseases; Humans; Isosorbide Dinitrate; Pentaerythritol Tetranitrate; Time Factors; Vasodilator Agents | 2002 |
[Therapy of portal hypertension].
Topics: Adrenergic beta-Antagonists; Esophageal and Gastric Varices; Esophagoscopy; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Isosorbide Dinitrate; Secondary Prevention; Survival Rate | 2002 |
NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Drug Administration Schedule; Flow Cytometry; Gastric Mucosa; Interleukin-1; Isoenzymes; Isosorbide Dinitrate; Male; Monocytes; Nitric Oxide; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha | 2002 |
Therapy for primary prophylaxis of varices: and, the winner is...?
Topics: Adrenergic beta-Antagonists; Esophageal and Gastric Varices; Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Propranolol; Randomized Controlled Trials as Topic; Vasodilator Agents | 2003 |
Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis.
Topics: Antihypertensive Agents; Ascites; Bacterial Infections; Cohort Studies; Drug Therapy, Combination; Female; Hemodynamics; Hemorrhage; Hepatic Encephalopathy; Hepatorenal Syndrome; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Peritonitis; Probability; Prognosis; Propranolol; Recurrence; Risk Factors; Survival Analysis; Time Factors; Varicose Veins; Vasodilator Agents | 2003 |
Preserved endothelial function after long-term eccentric isosorbide mononitrate despite moderate nitrate tolerance.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Isosorbide Dinitrate; Models, Cardiovascular; Nitric Oxide Donors; Phenylephrine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Statistics as Topic; Superoxides; Time; Treatment Outcome; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Amelioration of nitrate tolerance: matching strategies with mechanisms.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Vasoconstriction; Vasodilation; Vasodilator Agents | 2003 |
"A la carte" treatment of portal hypertension or just "hors d'oeuvres".
Topics: Gastrointestinal Hemorrhage; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Losartan; Prazosin; Propranolol | 2003 |
Optimal use of propranolol.
Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Ligation; Propranolol | 2003 |
Effect of nitric oxide on exercise-induced proteinuria in rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Isosorbide Dinitrate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Physical Exertion; Proteinuria; Rats; Rats, Wistar; Renal Circulation | 2003 |
Isosorbide-5-mononitrate treatment prevents cyclosporin A-induced platelet hyperactivation and the underlying nitric oxide-cyclic guanosine-3',5'-monophosphate disturbances.
Topics: Animals; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Cyclosporine; Intracellular Membranes; Isosorbide Dinitrate; Male; Microscopy, Electron; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Osmolar Concentration; Rats; Rats, Wistar | 2003 |
Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography.
Topics: Aspirin; Chlorzoxazone; Chromatography, High Pressure Liquid; Isosorbide Dinitrate; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Development and evaluation of extended release formulations of isosorbide mononitrate based on osmotic technology.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Osmosis; Osmotic Pressure; Predictive Value of Tests; Technology, Pharmaceutical | 2003 |
[Vasopressin analogue injection as ultimate measure for counteracting severe catecholamine-refractory poisoning by several vasodilators taken with suicidal intent].
Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Angiography; Angiotensin-Converting Enzyme Inhibitors; Arginine Vasopressin; Benzazepines; Female; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Injections, Intravenous; Isosorbide Dinitrate; Mesenteric Arteries; Mianserin; Mirtazapine; Poisoning; Suicide, Attempted; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
In vivo cardioprotection by N-acetylcysteine and isosorbide 5-mononitrate in a rat model of ischemia-reperfusion.
Topics: Acetylcysteine; Animals; Blood Pressure; Drug Therapy, Combination; Free Radical Scavengers; Isosorbide Dinitrate; Male; Monocytes; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophils; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley | 2003 |
[Results of international study of quality of life of patients with stable angina treated with nitrates (IQOLAN)].
Topics: Angina Pectoris; Exercise Tolerance; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Patient Satisfaction; Quality of Life; Treatment Outcome | 2003 |
[Quality of life of patients with ischemic heart disease taking isosorbide-5-mononitrate in an outpatient setting].
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nitric Oxide Donors; Quality of Life; Treatment Outcome | 2003 |
Exercise and nitric oxide prevent bubble formation: a novel approach to the prevention of decompression sickness?
Topics: Animals; Decompression Sickness; Diving; Female; Isosorbide Dinitrate; Motor Activity; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley | 2004 |
Compatibility studies between isosorbide mononitrate and selected excipients used in the development of extended release formulations.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Excipients; Isosorbide Dinitrate; Tablets, Enteric-Coated; Technology, Pharmaceutical | 2004 |
Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug.
Topics: Animals; Endothelium, Vascular; In Vitro Techniques; Indicators and Reagents; Isosorbide Dinitrate; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Oxidation-Reduction; Oximes; Rats; Rats, Wistar; Vasodilator Agents | 2004 |
Comparison of once daily versus twice daily oral nitrates in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Humans; Isosorbide Dinitrate; Middle Aged; Patient Compliance; Randomized Controlled Trials as Topic; Treatment Outcome; Vasodilator Agents | 2004 |
Management of cirrhosis and ascites.
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Nadolol; Propranolol; Secondary Prevention; Vasodilator Agents | 2004 |
Inhibition of vascular oxidative stress in hypercholesterolemia by eccentric isosorbide mononitrate.
Topics: Animals; Antioxidants; Aorta, Thoracic; Biological Availability; Cholesterol; Disease Models, Animal; Endothelium, Vascular; Female; Hypercholesterolemia; Isosorbide Dinitrate; Nitric Oxide Donors; Oxidative Stress; Rabbits; Superoxides; Tunica Intima; Tunica Media | 2004 |
Long-term therapy with organic nitrates: the pros and cons of nitric oxide replacement therapy.
Topics: Animals; Antioxidants; Clinical Trials as Topic; Drug Tolerance; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide Donors; Oxidation-Reduction; Prodrugs; Time Factors | 2004 |
[Inhibition of adenosine deaminase activity by drugs influencing the cardiovascular system].
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Aspirin; Cardiovascular Agents; Cardiovascular System; Deoxyadenosines; Female; Fibrinolytic Agents; Isoenzymes; Isosorbide Dinitrate; Male; Metoprolol; Molsidomine; Rabbits; Random Allocation; Simvastatin; Vasodilator Agents; Vasomotor System | 2004 |
[Severe pulmonary complications of massive intoxication with calcium channel blockers and isosorbide mononitrate--a case report].
Topics: Adult; Calcium Channel Blockers; Diltiazem; Humans; Isosorbide Dinitrate; Male; Respiratory Distress Syndrome; Suicide, Attempted; Treatment Outcome; Vasodilator Agents; Verapamil | 2004 |
In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis.
Topics: Administration, Oral; Animals; Confidence Intervals; Delayed-Action Preparations; Dogs; Female; Isosorbide Dinitrate; Predictive Value of Tests | 2005 |
Effect of preventive and regressive isosorbide 5-mononitrate treatment on catecholamine levels in plasma, platelets, adrenals, left ventricle and aorta in cyclosporin A-induced hypertensive rats.
Topics: Adrenal Glands; Animals; Aorta; Blood Platelets; Blood Pressure; Catecholamines; Chemoprevention; Cyclosporine; Heart Rate; Heart Ventricles; Hypertension; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Rats; Rats, Wistar | 2005 |
The effect of a combined treatment with propranolol and isosorbide-5-mononitrate on Doppler ultrasound parameters in patients with cirrhosis and portal hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Flow Velocity; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension, Portal; Isosorbide Dinitrate; Liver Cirrhosis; Male; Portal Vein; Propranolol; Prospective Studies; Treatment Outcome; Ultrasonography, Doppler; Vasodilator Agents | 2005 |
Curative isosorbide-5-mononitrate treatment, in opposition to the beneficial preventive one, aggravates the prothrombotic and proconstrictor state in cyclosporine-induced hypertensive rats.
Topics: Animals; Aorta; Blood Platelets; Cyclic GMP; Cyclosporine; Epoprostenol; Hypertension; Isosorbide Dinitrate; Lipid Peroxidation; Platelet Activation; Rats; Rats, Wistar; Thromboxane A2; Vasoconstriction | 2005 |
Nitroglycerin: a blast from the past remains a trusted standby. Nitrates offer quick, effective relief from a common heart disease symptom, often for just pennies per dose.
Topics: Angina Pectoris; Drug Interactions; Humans; Isosorbide Dinitrate; Myocardial Infarction; Nitroglycerin; Vasodilator Agents | 2005 |
A case of takotsubo-shaped hypokinesis of the left ventricle caused by a lightning strike.
Topics: Aspirin; Cardiomyopathies; Drug Therapy, Combination; Female; Heart Injuries; Heart Ventricles; Humans; Hypokinesia; Isosorbide Dinitrate; Lightning Injuries; Middle Aged; Mountaineering | 2005 |
[Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina].
Topics: Adult; Aged; Angina Pectoris; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Exercise Test; Exercise Tolerance; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Physical Exertion; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation; Vasodilator Agents | 2005 |
[ECG and BP monitoring in patients with stable angina and essential hypertension on therapy with monocinque].
Topics: Adult; Aged; Angina Pectoris; Blood Pressure Monitors; Delayed-Action Preparations; Electrocardiography, Ambulatory; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide Donors; Time Factors; Treatment Outcome; Vasodilator Agents | 2005 |
[Determination of isosorbide-5-nitrate in human plasma by reversed-phase high performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Humans; Isosorbide Dinitrate; Reproducibility of Results | 2005 |
Quantification of isosorbide 5-mononitrate in human plasma by liquid chromatography-tandem mass spectrometry using atmospheric pressure photoionization.
Topics: Atmospheric Pressure; Chromatography, Liquid; Humans; Isosorbide Dinitrate; Mass Spectrometry; Photochemistry; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Therapeutic Equivalency; Vasodilator Agents | 2006 |
[Hemorrhage due to peristomal ectopic varices: an infrequent complication of portal hypertension].
Topics: Cecal Neoplasms; Colonic Neoplasms; Diabetes Mellitus, Type 2; Duodenal Ulcer; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Ileostomy; Isosorbide Dinitrate; Male; Middle Aged; Peptic Ulcer Hemorrhage; Postoperative Complications; Propranolol; Surgical Stomas; Varicose Veins | 2006 |
Why is she fainting?
Topics: Aged; Angina Pectoris, Variant; Defibrillators, Implantable; Female; Heart Block; Humans; Isosorbide Dinitrate; Nifedipine; Syncope; Tachycardia, Ventricular; Vasodilator Agents | 2006 |
An extensive study on isosorbide-5-mononitrate acid adducts for quantification in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry and its application to bioequivalence sample analysis.
Topics: Acetylation; Administration, Oral; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Therapeutic Equivalency | 2006 |
High performance liquid chromatography-electrospray ionization mass spectrometric determination of isosorbide 5-mononitrate in human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Vasodilator Agents | 2007 |
Development of a novel nitrate-selective composite sensor based on doped polypyrrole.
Topics: Calibration; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Nitrates; Polymers; Pyrroles; Sensitivity and Specificity | 2007 |
Do we still need organic nitrates?
Topics: Cardiovascular Diseases; Endothelium, Vascular; Free Radicals; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide Donors; Vasodilator Agents | 2007 |
[Endothelial dysfunction in patients with chronic heart failure, and possibilities of its correction with isosorbide-5-mononitrates].
Topics: Administration, Oral; Aged; Brachial Artery; Delayed-Action Preparations; Disease Progression; Dose-Response Relationship, Drug; Endothelium, Vascular; Exercise Test; Follow-Up Studies; Heart Failure; Humans; Isosorbide Dinitrate; Male; Stroke Volume; Treatment Outcome; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents | 2007 |
Coronary stenting for coronary vasospasm refractory to medical therapy.
Topics: Blood Vessel Prosthesis Implantation; Calcium Channels; Coronary Angiography; Coronary Vasospasm; Delayed-Action Preparations; Diltiazem; Electrocardiography; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Revascularization; Stents; Vasodilator Agents | 2007 |
[Effect of isosorbide-5-mononitrate on sympathetic purinergic vasoconstriction of the rabbit saphenous artery].
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Arteries; Delayed-Action Preparations; Electric Stimulation; Isosorbide Dinitrate; Male; Norepinephrine; Prazosin; Purinergic P2 Receptor Agonists; Rabbits; Receptors, Purinergic P2X; Vasoconstriction | 2007 |
Oxidative stress in cyclosporine-induced hypertension: evidence of beneficial effects or tolerance development with nitrate therapy.
Topics: Animals; Cyclosporine; Hypertension; Immune Tolerance; Immunosuppressive Agents; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Oxidative Stress; Rats; Rats, Wistar | 2007 |
Assessment of acute pulmonary vascular reactivity in portopulmonary hypertension.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Epoprostenol; Female; Hemodynamics; Humans; Hypertension, Portal; Hypertension, Pulmonary; Injections, Intravenous; Isosorbide Dinitrate; Lung; Male; Middle Aged; Nitric Oxide; Pulmonary Circulation; Respiratory Function Tests; Vascular Resistance; Vasodilator Agents | 2007 |
Research and clinical value of antibacterial-application software.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cefepime; Cephalosporins; Enterobacter cloacae; Enterobacteriaceae Infections; Female; Gentamicins; Humans; Imipenem; Isosorbide Dinitrate; Male; Ofloxacin; Software | 2008 |
Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.
Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Drug Carriers; Glycerol; In Vitro Techniques; Isosorbide Dinitrate; Liposomes; Male; Rats; Rats, Wistar; Skin Absorption; Vasodilator Agents | 2008 |
Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network.
Topics: Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Excipients; Food-Drug Interactions; Isosorbide Dinitrate; Models, Biological; Neural Networks, Computer; Starch; Tablets; Time Factors | 2008 |
Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase.
Topics: Administration, Oral; Analysis of Variance; Animals; Aorta, Thoracic; Blotting, Western; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Isosorbide Dinitrate; Lung; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Donors; Pentaerythritol Tetranitrate; Protein Subunits; Rabbits; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilator Agents | 2008 |
Effect of large volume injection of hydrophobic solvents on the retention of less hydrophobic pharmaceutical solutes in RP-LC.
Topics: Chromatography, Liquid; Heptanes; Hexanes; Hydrophobic and Hydrophilic Interactions; Isosorbide Dinitrate; Molecular Structure; Octanes; Parabens; Pentoxifylline; Sensitivity and Specificity; Solubility; Solvents; Tropicamide | 2008 |
[Studies on preparation of isosorbide-5-mononitrate pulsatile controlled-release pellets and various influence factors].
Topics: Capsules; Cellulose; Delayed-Action Preparations; Drug Carriers; Hypromellose Derivatives; Isosorbide Dinitrate; Methylcellulose | 2008 |
Development of monolithic osmotic pump tablet system for isosorbide-5-mononitrate delivery and evaluation of it in vitro and in vivo.
Topics: Animals; Biological Availability; Chromatography, Gas; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Dogs; Drug Compounding; Drug Delivery Systems; In Vitro Techniques; Isosorbide Dinitrate; Male; Osmosis; Tablets; Technology, Pharmaceutical; Time Factors; Vasodilator Agents | 2009 |
Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and isosorbide mononitrate.
Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Benzoic Acid; Electrolysis; Hydrogen-Ion Concentration; In Vitro Techniques; Isosorbide Dinitrate; Lidocaine; Male; Mice; Mice, Hairless; Oxidation-Reduction; Permeability; Pharmaceutical Vehicles; Skin Absorption; Vasodilator Agents; Water | 2009 |
Design and evaluation of pH-independent pulsatile release pellets containing isosorbide-5-mononitrate.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Dogs; Drug Design; Drug Stability; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Nitric Oxide Donors; Reference Standards | 2009 |
Early identification of haemodynamic response to pharmacotherapy is essential for primary prophylaxis of variceal bleeding in patients with 'high-risk' varices.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Isosorbide Dinitrate; Liver Cirrhosis; Male; Middle Aged; Propranolol; Risk Factors; Treatment Outcome; Vasodilator Agents; Young Adult | 2009 |
The role of nitric oxide in the expression of renal aquaporin 2 in a cirrhotic rat model: does an AVP-independent mechanism exist for the regulation of AQP2 expression?
Topics: Analysis of Variance; Animals; Aquaporin 2; Biopterins; Cyclic GMP; Disease Models, Animal; Immunoenzyme Techniques; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Statistics, Nonparametric; Thioacetamide | 2010 |
Molecularly targeted therapies for glioma.
Topics: Angiogenesis Inhibitors; Anticarcinogenic Agents; Brain Neoplasms; Enzyme Inhibitors; Glioma; Humans; Isosorbide Dinitrate; Signal Transduction | 2009 |
Gastrointestinal bleeding: Secondary prophylaxis for variceal bleeding.
Topics: Adrenergic beta-Antagonists; Delayed-Action Preparations; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Gastroplasty; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Portasystemic Shunt, Transjugular Intrahepatic; Sclerotherapy; Secondary Prevention; Treatment Outcome | 2010 |
[Cardiotoxicity induced by 5-fluorouracil or capecitabine].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Heart; Heart Diseases; Humans; Isosorbide Dinitrate; Nitroglycerin; Prodrugs; Risk Factors; Vasodilator Agents | 2010 |
Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glutathione; Isosorbide Dinitrate; Liver; Male; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Silymarin | 2010 |
Use of organic nitrates and the risk of hip fracture: a population-based case-control study.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Epidemiologic Methods; Female; Hip Fractures; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitroglycerin; Odds Ratio; Population; Risk; Vasodilator Agents; Young Adult | 2010 |
Differences between nitrates: role of isosorbide 2-mononitrate.
Topics: Animals; Aorta; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitroglycerin; Perfusion; Rabbits; Vasodilation; Vasodilator Agents | 2010 |
Effects of isosorbide mononitrate on the restoration of injured artery in mice in vivo.
Topics: Animals; Arginine; Carotid Artery Injuries; Electric Stimulation; Endothelial Cells; Isosorbide Dinitrate; Mice | 2010 |
Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophoresis, Capillary; Endothelium, Vascular; In Vitro Techniques; Isosorbide Dinitrate; Magnetic Resonance Spectroscopy; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Spectrophotometry, Infrared; Stereoisomerism; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Isosorbide-5-mononitrate (5-ISMN) sustained-release pellets prepared by double layer coating for reducing 5-ISMN migration and sublimation.
Topics: Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Drug Stability; Drug Storage; Excipients; Humidity; Isosorbide Dinitrate; Polymethacrylic Acids; Povidone; Solubility; Technology, Pharmaceutical; Temperature | 2010 |
Study on dissolution and absorption of four dosage forms of isosorbide mononitrate: level A in vitro-in vivo correlation.
Topics: Absorption; Administration, Oral; Animals; Biological Availability; Dogs; Dosage Forms; Isosorbide Dinitrate; Male; Rats; Rats, Wistar; Solubility; Tablets; Therapeutic Equivalency | 2011 |
A case of recurrent ventricular tachycardia.
Topics: Aged; Atorvastatin; Cardiovascular Agents; Digoxin; Drug Therapy, Combination; Female; Furosemide; Heptanoic Acids; Humans; Isosorbide Dinitrate; Lisinopril; Nitroglycerin; Pyrroles; Recurrence; Tachycardia, Ventricular; Warfarin | 2011 |
Long-term oral nitrate therapy is associated with adverse outcome in diabetic patients following elective percutaneous coronary intervention.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Hong Kong; Humans; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Vasodilator Agents | 2011 |
A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology.
Topics: Acrylic Resins; Animals; Carbonic Anhydrases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glaucoma; Isosorbide Dinitrate; Male; Molecular Structure; Nitrates; Nitric Oxide; Rabbits; Sulfonamides; Thiophenes; Time Factors | 2012 |
Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Silencing; GTP Cyclohydrolase; Heme Oxygenase-1; Isosorbide Dinitrate; Male; NADPH Oxidases; Oxidative Stress; Pentaerythritol Tetranitrate; Rats; Rats, Wistar; Reactive Oxygen Species; Vasoconstriction; Vasodilator Agents; Weight Gain; Xanthine Oxidase | 2011 |
Contaminated drugs are held responsible for 120 deaths in Pakistan.
Topics: Antimalarials; Drug and Narcotic Control; Drug Contamination; Hospital Mortality; Humans; Isosorbide Dinitrate; Pakistan; Pyrimethamine; Vasodilator Agents | 2012 |
Pakistan's deadly cocktail of substandard drugs.
Topics: Drug Approval; Drug Contamination; Federal Government; Humans; Isosorbide Dinitrate; Pakistan; Public Health; World Health Organization | 2012 |
Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression.
Topics: Animals; Aorta; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Isosorbide Dinitrate; Male; Mice; Mice, Knockout; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Superoxides | 2013 |
Isosorbide-5-mononitrate and endothelial function: a wolf in sheep's clothing.
Topics: Animals; Endothelin-1; Endothelium, Vascular; Isosorbide Dinitrate; Male; Nitric Oxide Donors; Oxidative Stress | 2013 |
I am a 37-year-old woman and was diagnosed with coronary artery spasms two years ago. I am taking Plavix, verapamil and Imdur for my condition. What other things can I do to help my heart?
Topics: Adult; Clopidogrel; Coronary Vasospasm; Coronary Vessels; Female; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Isosorbide Dinitrate; Ticlopidine; Vasodilator Agents; Verapamil | 2011 |
I take three different blood pressure medications-six pills total-every day. They are isosorbide mononitrate, amlodipine, and atenolol. They seem to do a good job bringing down my blood pressure, but before my 6 p.m. atenolol and then later before my 10 p
Topics: Amlodipine; Atenolol; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Drug Administration Schedule; Health Status; Humans; Hypertension; Isosorbide Dinitrate; Vasodilator Agents | 2011 |
In vitro dissolution and in vivo bioequivalence evaluation of two brands of isosorbide 5-mononitrate sustained release tablets.
Topics: Adult; Algorithms; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; Indicators and Reagents; Isosorbide Dinitrate; Male; Postprandial Period; Reproducibility of Results; Solubility; Tandem Mass Spectrometry; Therapeutic Equivalency; Vasodilator Agents; Young Adult | 2012 |
A novel multi-unit tablet for treating circadian rhythm diseases.
Topics: Administration, Oral; Angina Pectoris; Cardiovascular Agents; Cellulose; Chemistry, Pharmaceutical; Chronobiology Disorders; Delayed-Action Preparations; Drug Carriers; Excipients; Hypromellose Derivatives; Isosorbide Dinitrate; Kinetics; Methacrylates; Methylcellulose; Microscopy, Electron, Scanning; Polymers; Solubility; Tablets; Technology, Pharmaceutical | 2013 |
Recurrent ventricular fibrillation under sufficient medical treatment in patient with coronary artery spasm.
Topics: Cardiovascular Agents; Coronary Vasospasm; Defibrillators, Implantable; Diagnosis, Differential; Diltiazem; Echocardiography; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Middle Aged; Nicorandil; Recurrence; Treatment Outcome; Ventricular Fibrillation | 2013 |
A simple and sensitive gas chromatography method for determination of isosorbide dinitrate and its metabolites in human plasma: application to pharmacokinetics study on oral spray.
Topics: Administration, Oral; Adult; Drug Stability; Humans; Isosorbide Dinitrate; Male | 2014 |
[The effects and its mechanism of N-arginine chitosan as transdermal enhancer].
Topics: Administration, Cutaneous; Animals; Arginine; Aspirin; Cell Line; Cell Survival; Cell-Penetrating Peptides; Chitosan; Drug Carriers; Humans; Isosorbide Dinitrate; Keratinocytes; Male; Mice; Prazosin; Skin Absorption | 2013 |
Chemically cross-linked poly(acrylic-co-vinylsulfonic) acid hydrogel for the delivery of isosorbide mononitrate.
Topics: Acrylic Resins; Chemistry, Pharmaceutical; Cross-Linking Reagents; Delayed-Action Preparations; Diffusion; Hydrogels; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Materials Testing; Methacrylates; Models, Chemical; Particle Size; Polyvinyls; Sulfonic Acids; Vasodilator Agents | 2013 |
Liposome-encapsulated ISMN: a novel nitric oxide-based therapeutic agent against Staphylococcus aureus biofilms.
Topics: Biofilms; Isosorbide Dinitrate; Liposomes; Nitric Oxide; Staphylococcal Infections; Staphylococcus aureus | 2014 |
Analysis of the pretreatment effect of ethanol on the stratum corneum- and hair follicular-penetration of drugs using the hair follicle-plugging method.
Topics: Animals; Dextrans; Ethanol; Fluorescein; Fluorescein-5-isothiocyanate; Hair Follicle; Isosorbide Dinitrate; Lidocaine; Skin; Skin Absorption; Structure-Activity Relationship; Swine | 2014 |
A novel micellar per aqueous liquid chromatographic method for simultaneous determination of diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum.
Topics: Chromatography, Liquid; Diltiazem; Drug Stability; Humans; Hydrogen-Ion Concentration; Isosorbide Dinitrate; Linear Models; Metoprolol; Micelles; Reproducibility of Results; Sensitivity and Specificity | 2014 |
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Blood Platelets; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Humans; Hypotension; Isosorbide Dinitrate; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Thrombin; Tyrosine; Vasodilator Agents | 2014 |
Effect of nitric oxide on spinal evoked potentials and survival rate in rats with decompression sickness.
Topics: Animals; Decompression Sickness; Evoked Potentials; Female; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Spinal Cord; Survival Rate | 2015 |
Diffuse three-vessel coronary artery spasm.
Topics: Atorvastatin; Coronary Vasospasm; Diagnosis, Differential; Diagnostic Imaging; Diltiazem; Drug Therapy, Combination; Electrocardiography; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Pyrroles; Risk Factors; Vasodilator Agents | 2015 |
Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aspirin; Colonic Neoplasms; Drug Synergism; Female; HCT116 Cells; Humans; Inhibitory Concentration 50; Isosorbide Dinitrate; Mice, Inbred BALB C; Mice, Nude; Nitric Oxide; Xenograft Model Antitumor Assays | 2015 |
Relationship between Nitrate-Induced Headache and Coronary Artery Lesion Complexity.
Topics: Aged; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Female; Headache; Humans; Isosorbide Dinitrate; Male; Middle Aged; Risk Assessment; Risk Factors; Severity of Illness Index; Vasodilator Agents | 2015 |
[Comparative Assessment of Effects of Isosorbide Dinitrate, Isosorbide-5-Mononitrate and Nicorandil on the Frequency of Angina Attacks and Vasoregulating Endothelial Function in Patients With Ischemic Heart Disease].
Topics: Adult; Aged; Angina Pectoris; Electrocardiography; Female; Humans; Incidence; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Risk Assessment; Russia; Vasodilation | 2015 |
Investigation of the Hepato-Protective Effects of Imdur in a Rat Model of Chronic Mountain Sickness.
Topics: Altitude Sickness; Animals; Biomarkers; Blood Pressure; C-Reactive Protein; Chronic Disease; Glutathione Peroxidase; Homocysteine; Hypoxia; Interleukin-6; Isosorbide Dinitrate; Liver; Malondialdehyde; Nifedipine; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2015 |
Long-term drug use and polypharmacy among the elderly population in the Republic of Srpska, Bosnia and Herzegovina.
Topics: Age Factors; Aged; Aged, 80 and over; Aminophylline; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Bosnia and Herzegovina; Bronchodilator Agents; Calcium Channel Blockers; Cardiovascular Agents; Digoxin; Female; Humans; Hypoglycemic Agents; Isosorbide Dinitrate; Male; Polypharmacy; Retrospective Studies; Sex Factors; Vasodilator Agents | 2016 |
A case of initial rhythm of pulseless electrical activity caused by vasospastic angina.
Topics: Angiocardiography; Cardiopulmonary Resuscitation; Coronary Angiography; Coronary Vasospasm; Dihydropyridines; Electrophysiologic Techniques, Cardiac; Heart Arrest; Humans; Isosorbide Dinitrate; Male; Middle Aged; Treatment Outcome; Vasodilator Agents | 2016 |
Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction.
Topics: Animals; Antihypertensive Agents; Carbazoles; Carvedilol; Hepatectomy; Isosorbide Dinitrate; Liver; Lypressin; Male; Octreotide; Portal Pressure; Propanolamines; Rats, Inbred Lew; Sildenafil Citrate; Splenectomy; Terlipressin; Vasoconstrictor Agents; Vasodilator Agents | 2017 |
ST elevation myocardial infarction after coronary artery spasm with no clear trigger.
Topics: Amlodipine; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Coronary Angiography; Coronary Vasospasm; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrocardiography; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Recurrence; ST Elevation Myocardial Infarction; Vasodilator Agents | 2017 |
A comparative study on the anti-schistosomal and hepatoprotective effects of vinpocetine and isosorbide-5-mononitrate on Schistosoma mansoni-infected mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Egypt; Female; Isosorbide Dinitrate; Mice; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Vinca Alkaloids | 2017 |
Controlled and Localized Nitric Oxide Precursor Delivery From Chitosan Gels to Staphylococcus aureus Biofilms.
Topics: Anti-Bacterial Agents; Biofilms; Chitosan; Ciprofloxacin; Drug Liberation; Gels; Humans; Isosorbide Dinitrate; Nitric Oxide; Polymers; Staphylococcal Infections; Staphylococcus aureus | 2017 |
NO donors exhibit anti-inflammatory properties by modulating inflammatory signatures and by regulating the life cycle of dendritic cells.
Topics: Animals; Anti-Inflammatory Agents; Antigen Presentation; Apoptosis; Bone Marrow Cells; Butanes; Cytokines; Dendritic Cells; Inflammation; Isosorbide Dinitrate; Lipopolysaccharides; Mice, Inbred C57BL; NF-KappaB Inhibitor alpha; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitrites; Nitro Compounds; Proteolysis | 2017 |
Mechanistic studies of the antibiofilm activity and synergy with antibiotics of isosorbide mononitrate.
Topics: Anti-Bacterial Agents; Biofilms; Ciprofloxacin; Isosorbide Dinitrate; Microbial Sensitivity Tests; Mupirocin; Nitric Oxide; Plankton; Staphylococcal Infections; Staphylococcus aureus | 2018 |
Identification of a Novel Hybridization from Isosorbide 5-Mononitrate and Bardoxolone Methyl with Dual Activities of Pulmonary Vasodilation and Vascular Remodeling Inhibition on Pulmonary Arterial Hypertension Rats.
Topics: Animals; Cardiomegaly; Drug Design; Fibrosis; Hypertension, Pulmonary; Isosorbide Dinitrate; Nitric Oxide Donors; Oleanolic Acid; Rats; Vascular Remodeling; Vasodilation | 2018 |
High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model.
Topics: Animals; Apoptosis; Dietary Fats; Disease Models, Animal; Hypertension; Insulin Resistance; Isosorbide Dinitrate; Male; Myocardium; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Wistar; Sucrose | 2018 |
Effectiveness of vinpocetine and isosorbide-5-mononitrate on experimental schistosomiasis mansoni: Biochemical and immunohistochemical study.
Topics: Animals; Anthelmintics; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Resistance; Female; Immunohistochemistry; Isosorbide Dinitrate; Mice; Schistosoma mansoni; Schistosomiasis mansoni; Vinca Alkaloids | 2018 |
Intravaginal rings for continuous low-dose administration of cervical ripening agents.
Topics: Administration, Intravaginal; Cervical Ripening; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Drug Liberation; Female; Humans; Isosorbide Dinitrate; Misoprostol; Pregnancy; Silicone Elastomers; Time Factors | 2018 |
Nitrate allergy and desensitization in a patient with refractory angina.
Topics: Aged; Angina Pectoris; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Humans; Injections, Intradermal; Isosorbide Dinitrate; Male; Nitroglycerin; Skin Tests; Vasodilator Agents | 2019 |
The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation.
Topics: Animals; Cells, Cultured; Endothelin Receptor Antagonists; Endothelium, Vascular; Humans; Inflammation; Isosorbide Dinitrate; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Pyrimidines; Rats; Rats, Wistar; Sulfonamides; Vascular Diseases; Vasodilator Agents | 2018 |
High-dose nitrate therapy recovers the expression of subtypes α
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Drug Therapy, Combination; Heart Failure; Imidazoles; Isosorbide Dinitrate; Kidney Cortex; Male; Myocardial Infarction; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Time Factors | 2020 |
Comparative analysis of cost-effectiveness between isosorbide-5-mononitrate and isosorbide: a retrospective real-world evaluation.
Topics: Administration, Sublingual; Aged; Aged, 80 and over; China; Coronary Disease; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Hypotension; Incidence; Isosorbide; Isosorbide Dinitrate; Length of Stay; Male; Middle Aged; Nitric Oxide Donors; Nitroglycerin; Pragmatic Clinical Trials as Topic; Propensity Score; Retrospective Studies; Vasodilator Agents | 2020 |
In silico prediction of bioequivalence of Isosorbide Mononitrate tablets with different dissolution profiles using PBPK modeling and simulation.
Topics: Computer Simulation; Humans; Isosorbide Dinitrate; Models, Biological; Solubility; Tablets; Therapeutic Equivalency | 2021 |
Letter to editor: comments on manuscript titled "intravaginal administration of isosorbide mononitrate for cervical ripening in prolonged pregnancy: a randomised clinical trial".
Topics: Administration, Intravaginal; Cervical Ripening; Female; Humans; Isosorbide Dinitrate; Pregnancy; Pregnancy, Prolonged | 2021 |
ISMN-loaded PLGA-PEG nanoparticles conjugated with anti-
Topics: Anti-Bacterial Agents; Biofilms; Chronic Disease; Isosorbide Dinitrate; Microbial Sensitivity Tests; Molecular Structure; Nanoparticles; Polyesters; Polyethylene Glycols; Rhinitis; Staphylococcus aureus | 2021 |
Quantitative Assessment of the in vivo Dissolution Rate to Establish a Modified IVIVC for Isosorbide Mononitrate Tablets.
Topics: Biological Availability; Humans; Isosorbide Dinitrate; Solubility; Tablets | 2023 |
Endocrine disruption: Reproductive toxicity of glyceryl trinitrate and isosorbide mononitrate in male Wistar rats.
Topics: Animals; Isosorbide Dinitrate; Luteinizing Hormone; Male; Nitrates; Nitric Oxide; Nitroglycerin; Oxidative Stress; Rats; Rats, Wistar; Semen; Sperm Count; Sperm Motility; Spermatozoa; Testis; Testosterone | 2022 |
Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy.
Topics: Artesunate; Female; Humans; Isosorbide Dinitrate; Nanoparticles; Ovarian Neoplasms; Polymers; Reactive Oxygen Species | 2022 |
The IBA-ISMO Method for Rolling Bearing Fault Diagnosis Based on VMD-Sample Entropy.
Topics: Algorithms; Engineering; Entropy; Isosorbide Dinitrate | 2023 |