isosorbide dinitrate has been researched along with cyclic gmp in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (25.00) | 18.7374 |
| 1990's | 38 (55.88) | 18.2507 |
| 2000's | 8 (11.76) | 29.6817 |
| 2010's | 5 (7.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, A; Ogawa, K | 1 |
| Cazenave, JP; Gachet, C; Guillou, J; Moog, S | 1 |
| Duboc, D; Guérin, F; Weber, S | 1 |
| Atanassova, R; Balansky, R; Boev, K; Spassov, G | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B; Valta-Seufzer, U | 1 |
| Feelisch, M; Kelm, M | 1 |
| Garg, UC; Hassid, A | 4 |
| Fitscha, P; O'Grady, J; Rauscha, F; Rogatti, W; Sinzinger, H; Vane, JR | 1 |
| Karaki, H; Murakami, K; Urakawa, N | 1 |
| Holzmann, S; Kukovetz, WR | 3 |
| Ahlner, J; Axelsson, KL; Torfgård, K | 1 |
| Hawlicek, J; Kalenbach, M; Kirsten, N; Kober, G; Krause, A; Satter, P; Schneider, W; von Loh, D; Weyenmeyer, T | 1 |
| Hashimoto, H; Ito, T; Nakagawa, H; Ogawa, K; Okumura, K; Satake, T | 1 |
| Holzmann, S; Kukovetz, WR; Romanin, C | 1 |
| Hayashi, K; Iwata, M; Ozawa, T; Sugiyama, S; Taki, F | 1 |
| Flaherty, JT | 1 |
| Matsuoka, I; Nakanishi, H; Sakurai, K | 1 |
| Kogi, K; Matsuoka, I; Nakanishi, H; Sakurai, K | 1 |
| Osnes, JB | 1 |
| DiSalvo, J; Galvas, PE | 1 |
| Cahill, PA; Foster, C; Redmond, EM; Sitzmann, JV | 1 |
| Bosmans, JM; Bult, H; Herman, AG; Vrints, CJ | 1 |
| Billiar, TR; Davies, P; Nakayama, DK; Pitt, BR; Simmons, RL; Thomae, KR | 1 |
| MacNaughton, WK | 1 |
| Bonetti, G; Ferro, M; Mengozzi, G; Mosso, R; Paradisi, L; Piccoli, G; Polloni, R; Roccatello, D; Sena, LM | 1 |
| Mügge, A; Riedel, M | 1 |
| Hirasawa, Y; Kita, Y; Maeda, K; Sugimoto, T; Yoshida, K | 1 |
| Cui, LN; Inenaga, K; Nagatomo, T; Yamashita, H | 1 |
| Adachi, H; Saeki, T; Saito, I; Souda, S; Takase, Y; Yoshitake, S | 1 |
| Barnes, CS; Coker, SJ | 1 |
| Do, YS; Elkayam, U; Fisher, DA; Hsueh, W; Hurst, A; Johnson, JV; Mehra, A; Ostrzega, E; Shotan, A | 1 |
| Kubo, M; Kuroda, Y; Matsuoka, S; Nakaya, Y; Saito, K | 1 |
| Brown, JF; Hanson, PJ; Keates, AC; Whittle, BJ | 1 |
| Geppetti, P; Granger, H; Ledda, F; Masini, E; Morbidelli, L; Ziche, M | 1 |
| Enomoto, T; Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H; Yasui, K | 1 |
| Fung, HL | 1 |
| Bath, PM | 1 |
| Kato, Y; Motoyama, Y; Nishio, M; Seki, J; Yoshida, K | 1 |
| Bonetti, G; Cesano, G; Ferro, M; Inconis, T; Mengozzi, G; Mosso, R; Paradisi, L; Polloni, R; Roccatello, D; Sena, LM | 1 |
| Brands, F; Feelisch, M; Kelm, M | 1 |
| Amado, JA; Berrazueta, JR; Ochoteco, A; Poveda, JJ; Riestra, A; Salas, E | 1 |
| Cahill, PA; Hodges, R; Redmond, EM; Sitzmann, JV; Zhang, S | 1 |
| Kojda, G; Kottenberg, K; Nix, P; Noack, E; Piper, HM; Schlüter, KD | 1 |
| Cremonesi, P; Donà, G; Giuliani, P; Mizrahi, J; Passaro, A; Stella, P; Tursi, F | 1 |
| Higasa, S; Kakishita, E; Oku, KI; Seto, T; Suehiro, A; Yoshimoto, H | 1 |
| Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H | 1 |
| Kakishita, E; Suehiro, A; Yoshimoto, H | 1 |
| Hinz, B; Kuntze, U; Schröder, H | 1 |
| Abate, A; Oberle, S; Schröder, H; Schwartz, P | 1 |
| Vaziri, ND; Wang, XQ | 1 |
| Brännström, M; Ekerhovd, E; Mattsby-Baltzer, I; Norström, A; Weijdegård, B | 1 |
| Alcobia, T; Almeida, L; Ferrer-Antunes, CA; Lourenço, M; Mesquita, JF; Palmeiro, A; Pontes, F; Reis, F; Santos-Dias, JD; Teixeira, F | 1 |
| Kloner, RA | 1 |
| Alcobia, T; Almeida, L; Costa-Almeida, C; Ferrer-Antunes, CA; Lourenço, M; Palmeiro, A; Ponte, L; Reis, F; Rocha, L; Teixeira, F; Teixeira-Lemos, E | 1 |
| Adams, MA; Bennett, BM; Frederiksen, LJ; Graham, CH; Macdonald-Goodfellow, SK; Maxwell, LR; Siemens, DR; Sullivan, R | 1 |
| Delgado, C; Fernández-Velasco, M; Mourelle, M; Ruiz-Hurtado, G | 1 |
| Movsesian, MA; Stehlik, J | 1 |
| Ahimastos, AA; Duffy, SJ; Formosa, MF; Henstridge, DC; Kingwell, BA; Thompson, BR | 1 |
| Jo, YJ; Jun, DW; Kang, JS; Kim, EK; Kim, KT; Kim, SH; Park, JH; Park, YS; Son, BK | 1 |
| Bonadei, I; Caretta, G; Cas, LD; Raddino, R; Teli, M; Vizzardi, E | 1 |
| Daiber, A; Daub, S; Doppler, C; Gori, T; Gottschlich, A; Kleinert, H; Knorr, M; Kossmann, S; Kröller-Schön, S; Münzel, T; Oelze, M; Rümmler, R; Schuff, A | 1 |
| Arsalane, A; Claes, V; Guerin, C; Guizard, M; Hébert, JL; Lecarpentier, E; Lecarpentier, Y; Michel, F; Moumen, A; Timbely, O | 1 |
| Carresi, C; Dagostino, C; Giancotti, LA; Gliozzi, M; Gratteri, S; Malara, N; Mollace, V; Muscoli, C; Muscoli, S; Musolino, V; Palma, E; Romeo, F; Sacco, I; Salvemini, D; Visalli, V; Vitale, C | 1 |
2 review(s) available for isosorbide dinitrate and cyclic gmp
| Article | Year |
|---|---|
Some pharmacological properties of organic nitrates.
Topics: Angina Pectoris; Animals; Arterioles; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Drug Tolerance; Humans; Inactivation, Metabolic; Isosorbide Dinitrate; Liver; Muscle, Smooth, Vascular; Myocardium; Nitrates; Nitroglycerin; Oxyhemoglobins; Vasodilation; Venous Pressure | 1984 |
Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenergic alpha-Antagonists; Arteriosclerosis; Blood Pressure; Carbolines; Contraindications; Coronary Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Interactions; Endothelium, Vascular; Erectile Dysfunction; Heart Rate; Humans; Hypotension; Imidazoles; Isosorbide Dinitrate; Male; Molecular Structure; Myocardial Infarction; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation; Vasodilator Agents | 2004 |
8 trial(s) available for isosorbide dinitrate and cyclic gmp
| Article | Year |
|---|---|
Comparison of anti-platelet properties of molsidomine, isosorbide-5-mononitrate and placebo in healthy volunteers.
Topics: Adult; Bleeding Time; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isosorbide Dinitrate; Male; Molsidomine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Reference Values; Thromboxane B2 | 1991 |
Isosorbidedinitrate and SIN-1 as dilators of human coronary arteries and platelet inhibitors.
Topics: Angina Pectoris; Blood Pressure; Coronary Vessels; Cyclic AMP; Cyclic GMP; Double-Blind Method; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1995 |
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis.
Topics: Cyclic GMP; Disease Progression; Endothelins; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Humans; Hypertension, Renal; Isosorbide Dinitrate; Nitric Oxide; Pilot Projects; Vasodilator Agents | 1995 |
[Direct effects of estrogens on vascular tone: characterization and clinical significance].
Topics: Administration, Sublingual; Aged; Aged, 80 and over; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Culture Techniques; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Echocardiography, Doppler; Estradiol; Estrogen Replacement Therapy; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vascular Resistance | 1994 |
Plasma cyclic guanosine monophosphate in chronic heart failure: hemodynamic and neurohormonal correlations and response to nitrate therapy.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Cyclic GMP; Female; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Neurotransmitter Agents | 1993 |
Effect of isosorbide-5-mononitrate on plasma and urine levels of cyclic GMP in relation to exercise in coronary patients compared with control subjects.
Topics: Angina Pectoris; Coronary Disease; Cyclic GMP; Exercise; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Vasodilator Agents | 1995 |
Nitric oxide induced cervical ripening in the human: Involvement of cyclic guanosine monophosphate, prostaglandin F(2 alpha), and prostaglandin E(2).
Topics: Cervical Ripening; Cervix Uteri; Cyclic AMP; Cyclic GMP; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dinoprostone; Female; Gestational Age; Humans; Immunoblotting; Isoenzymes; Isosorbide Dinitrate; Membrane Proteins; Microscopy, Electron; Nitric Oxide; Nitric Oxide Donors; Pregnancy; Prostaglandin-Endoperoxide Synthases | 2002 |
Oral nitrate therapy does not affect glucose metabolism in healthy men.
Topics: Adult; Blood Glucose; Cyclic GMP; Delayed-Action Preparations; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pentaerythritol Tetranitrate; Pulmonary Circulation | 2009 |
58 other study(ies) available for isosorbide dinitrate and cyclic gmp
| Article | Year |
|---|---|
Effects of coronary vasodilator on cyclic nucleotides. The concentrations of cyclic AMP and cyclic GMP in canine coronary artery and left ventricular muscle following the administration of various coronary vasodilators.
Topics: Amyl Nitrite; Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Diltiazem; Dipyridamole; Dogs; Heart Ventricles; Isosorbide Dinitrate; Myocardium; Nifedipine; Nitroglycerin; Papaverine; Radioimmunoassay; Vasodilator Agents | 1979 |
[Isosorbide dinitrate inhibits in vitro platelet aggregation at submicromolar concentrations].
Topics: Cyclic GMP; Drug Synergism; Epoprostenol; In Vitro Techniques; Isosorbide Dinitrate; Platelet Aggregation; Platelet Aggregation Inhibitors; Quercetin | 1992 |
[Mechanism of cellular action of nitrate derivatives].
Topics: Cyclic GMP; Humans; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitroglycerin; Protein Kinases; Vasodilation | 1992 |
Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of the guinea-pig and dog.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dogs; Guinea Pigs; Heart; In Vitro Techniques; Isosorbide Dinitrate; Myocardial Contraction; Vasodilator Agents | 1992 |
Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells.
Topics: Animals; Aorta, Thoracic; Biotransformation; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Hot Temperature; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Radioimmunoassay; Swine; Temperature | 1991 |
Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Ascorbic Acid; Cell Division; Cell Line; Cyclic GMP; DNA; Dose-Response Relationship, Drug; Hemoglobins; Isosorbide Dinitrate; Mice; Mitosis; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine | 1990 |
Nitric oxide decreases cytosolic free calcium in Balb/c 3T3 fibroblasts by a cyclic GMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Line; Cyclic AMP; Cyclic GMP; Cytosol; Fibroblasts; Isosorbide Dinitrate; Kinetics; Mice; Mice, Inbred BALB C; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1991 |
Effect of prostaglandin E1 and (the NO-donor) isosorbidedinitrate on thromboresistance in human in-vivo.
Topics: Adult; Aged; Alprostadil; Blood Platelets; Cardiovascular Diseases; Cyclic GMP; Drug Synergism; Drug Therapy, Combination; Female; Humans; Indium Radioisotopes; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Random Allocation; Thrombosis | 1990 |
Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta.
Topics: Animals; Aorta; Calcium; Cyclic GMP; In Vitro Techniques; Ion Channels; Isosorbide Dinitrate; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rabbits | 1987 |
Cyclic GMP in nicorandil-induced vasodilatation and tolerance development.
Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1987 |
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Cyclic GMP; Growth Inhibitors; Hemoglobins; Isosorbide Dinitrate; Mitosis; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1989 |
Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators.
Topics: Animals; Cell Division; Cells, Cultured; Cyclic GMP; DNA; Free Radicals; Glomerular Mesangium; Hemoglobins; Isosorbide Dinitrate; Nitric Oxide; Nitroprusside; Rats; Vasodilator Agents | 1989 |
Effect of pertussis toxin and the cGMP lowering agent LY83583 on the relaxation induced by nitrates in isolated bovine mesenteric artery. A comparison between glyceryl trinitrate, isosorbide dinitrate and isosorbide 5-mononitrate.
Topics: Aminoquinolines; Animals; Cattle; Cyclic GMP; Isosorbide Dinitrate; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Pertussis Toxin; Vascular Resistance; Virulence Factors, Bordetella | 1989 |
[Isolated human venous segments as a model for the study of problems of nitrate tolerance].
Topics: Acetylcysteine; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitroglycerin; Saphenous Vein; Vascular Resistance; Vasodilation | 1989 |
Effects of atrial natriuretic polypeptide and organic nitrates on levels of relaxation and cyclic nucleotide of canine coronary artery with and without endothelial injury.
Topics: Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Endothelium, Vascular; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilation | 1988 |
Mode of action of nitrates with regard to vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1986 |
Mechanism of vasodilation by nitrates: role of cyclic GMP.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilator Agents | 1987 |
Effect of nipradilol, a new beta-blocker, on leukotriene D4-induced contraction in guinea pig tracheal smooth muscle.
Topics: Adrenergic beta-Antagonists; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isosorbide Dinitrate; Leukotriene B4; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Propanolamines; Propranolol; Trachea | 1988 |
Mechanisms of nitrate-induced vasodilatation and tolerance on a biochemical base.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Cattle; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Isosorbide Dinitrate; Methylene Blue; Nitrates; Nitroglycerin; Nitroprusside; Vasodilation | 1985 |
Hemodynamic attenuation and the nitrate-free interval: alternative dosing strategies for transdermal nitroglycerin.
Topics: Acetylcysteine; Administration, Oral; Administration, Topical; Angina Pectoris; Angina, Unstable; Animals; Blood Vessels; Cheek; Cyclic GMP; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Endothelium; Exercise Test; Hemodynamics; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Nitroglycerin; Prostaglandins; Vascular Resistance | 1985 |
Isosorbide 5-mononitrate effects on isolated rabbit aorta and vena cava: relationship between cyclic GMP and relaxation of vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Vena Cava, Inferior | 1985 |
A comparison of the effects of isosorbide dinitrate on isolated rabbit aorta and vena cava: role of guanosine 3',5'-cyclic monophosphate in vascular smooth muscle relaxation.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Rabbits; Vasodilation; Vena Cava, Inferior | 1986 |
Concentration and time-dependent relationships between isosorbide dinitrate-induced relaxation and formation of cyclic GMP in coronary arterial smooth muscle.
Topics: Animals; Cattle; Cyclic GMP; Guanylate Cyclase; Isosorbide Dinitrate; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular | 1983 |
Nitric oxide regulates angiotensin II receptors in vascular smooth muscle cells.
Topics: Amino Acid Oxidoreductases; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Bucladesine; Cyclic GMP; Down-Regulation; Extracellular Space; In Vitro Techniques; Isosorbide Dinitrate; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Penicillamine; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
The effect of nitric oxide on fetal pulmonary artery smooth muscle growth.
Topics: Animals; Cell Survival; Cells, Cultured; Cyclic GMP; DNA; Female; Fetus; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Pregnancy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thymidine; Tritium | 1995 |
Nitric oxide-donating compounds stimulate electrolyte transport in the guinea pig intestine in vitro.
Topics: Amino Acid Oxidoreductases; Animals; Biological Transport; Cyclic GMP; Electrolytes; Female; Guinea Pigs; Ileum; In Vitro Techniques; Isosorbide Dinitrate; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside | 1993 |
Close correlation of the cardioprotective effect of FK409, a spontaneous NO releaser, with an increase in plasma cyclic GMP level.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Isosorbide Dinitrate; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitro Compounds; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Sodium nitroprusside modulates NMDA response in the rat supraoptic neurons in vitro.
Topics: Animals; Arginine; Cyclic GMP; Ferricyanides; In Vitro Techniques; Isosorbide Dinitrate; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurons; Nitroarginine; Nitroprusside; Protein Kinases; Quisqualic Acid; Rats; Rats, Wistar; Supraoptic Nucleus | 1994 |
A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery.
Topics: Animals; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Isosorbide Dinitrate; Male; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Rabbits; Swine; Vasodilation | 1995 |
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Hemodynamics; Isosorbide Dinitrate; Male; Molsidomine; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Ion Channel Gating; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Potassium Channels; Rats | 1994 |
Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Isosorbide Dinitrate; Male; Mucins; Mucus; Nitric Oxide; Rats; Rats, Wistar | 1993 |
Nitric oxide promotes DNA synthesis and cyclic GMP formation in endothelial cells from postcapillary venules.
Topics: Animals; Arginine; Cattle; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA; DNA Replication; Endothelium, Vascular; Fibroblast Growth Factor 2; Isosorbide Dinitrate; Kinetics; Nitric Oxide; Nitroglycerin; Nitroprusside; omega-N-Methylarginine; Thymidine; Venules | 1993 |
Platelet cyclic GMP. A potentially useful indicator to evaluate the effects of nitroglycerin and nitrate tolerance.
Topics: Atrial Natriuretic Factor; Blood Platelets; Coronary Angiography; Coronary Vessels; Cyclic GMP; Drug Tolerance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Vasodilation | 1993 |
Solving the mystery of nitrate tolerance. A new scent on the trail?
Topics: Blood Platelets; Coronary Vessels; Cyclic GMP; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitroglycerin; Vasodilation | 1993 |
The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro.
Topics: Cell Migration Inhibition; Chemotaxis, Leukocyte; Cyclic GMP; Humans; Isosorbide Dinitrate; Molsidomine; Monocytes; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1993 |
FK409, a new nitric-oxide donor, suppresses smooth muscle proliferation in the rat model of balloon angioplasty.
Topics: Angioplasty, Balloon; Animals; Bromodeoxyuridine; Carotid Arteries; Carotid Artery Injuries; Cell Division; Cells, Cultured; Cyclic GMP; Disease Models, Animal; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitro Compounds; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasodilator Agents | 1995 |
Isosorbide 5 mononitrate administration increases nitric oxide blood levels and reduces proteinuria in IgA glomerulonephritis patients with abnormal urinary endothelin/cyclic GMP ratio.
Topics: Adult; Blood Pressure; Cyclic GMP; Electron Spin Resonance Spectroscopy; Endothelins; Female; Glomerulonephritis, IGA; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Proteinuria; Vasodilator Agents | 1995 |
Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms.
Topics: Biotransformation; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide; Nitroglycerin; Platelet Aggregation; Time Factors | 1995 |
Regulation of endothelin receptors by nitric oxide in cultured rat vascular smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endothelins; In Vitro Techniques; Interleukin-1; Isosorbide Dinitrate; Male; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 1996 |
Low increase in cGMP induced by organic nitrates and nitrovasodilators improves contractile response of rat ventricular myocytes.
Topics: Animals; Cells, Cultured; Cyclic GMP; Electric Stimulation; Heart Ventricles; Hydrazines; Isosorbide Dinitrate; Male; Myocardial Contraction; Nitrogen Oxides; Nitroglycerin; Penicillamine; Pentaerythritol Tetranitrate; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1996 |
Mechanism of ITF 296-induced vasorelaxation compared to nitroglycerin and isosorbide dinitrate: relationship between relaxation of rabbit aorta and tissue cGMP.
Topics: Animals; Aorta, Thoracic; Benzoxazines; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Oxazines; Rabbits; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
[Inhibitory effect of isosorbide dinitrate on whole blood aggregation].
Topics: Angina Pectoris; Blood; Cell Aggregation; Cyclic GMP; Female; Humans; In Vitro Techniques; Isosorbide Dinitrate; Leukocytes; Male; Methylene Blue; Middle Aged; Myocardial Infarction; omega-N-Methylarginine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1997 |
Effects of enalapril during continuous nitrate therapy: analysis of diameter of coronary arteries and platelet cyclic guanosine monophosphate.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Platelets; Case-Control Studies; Coronary Angiography; Coronary Disease; Coronary Vessels; Cyclic GMP; Drug Administration Schedule; Enalapril; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Norepinephrine; Renin; Vasodilator Agents | 1997 |
Exogenous nitric oxide inhibits platelet activation in whole blood.
Topics: Arginine; Blood Coagulation; Blood Platelets; Collagen; Cyclic GMP; Humans; In Vitro Techniques; Isosorbide Dinitrate; Nitric Oxide; Nitroprusside; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents; Whole Blood Coagulation Time | 1999 |
Pentaerithrityl tetranitrate and its phase I metabolites are potent activators of cellular cyclic GMP accumulation.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Epithelial Cells; Erythrityl Tetranitrate; Guanylate Cyclase; Isosorbide Dinitrate; Kidney; Nitric Oxide Donors; Swine | 1998 |
The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.
Topics: Animals; Antioxidants; Aorta; Cells, Cultured; Cyclic GMP; Cyclic N-Oxides; Deferoxamine; Endothelium, Vascular; Ferritins; Free Radical Scavengers; Gene Expression; Guanylate Cyclase; Imidazoles; Iron Chelating Agents; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Pentaerythritol Tetranitrate; Spermine; Swine | 1999 |
cGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Coronary Vessels; Cyclic GMP; Down-Regulation; Endothelium, Vascular; Feedback; Guanylate Cyclase; Hemoglobins; Humans; Isosorbide Dinitrate; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilator Agents | 1999 |
Isosorbide-5-mononitrate treatment prevents cyclosporin A-induced platelet hyperactivation and the underlying nitric oxide-cyclic guanosine-3',5'-monophosphate disturbances.
Topics: Animals; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Cyclosporine; Intracellular Membranes; Isosorbide Dinitrate; Male; Microscopy, Electron; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Osmolar Concentration; Rats; Rats, Wistar | 2003 |
Curative isosorbide-5-mononitrate treatment, in opposition to the beneficial preventive one, aggravates the prothrombotic and proconstrictor state in cyclosporine-induced hypertensive rats.
Topics: Animals; Aorta; Blood Platelets; Cyclic GMP; Cyclosporine; Epoprostenol; Hypertension; Isosorbide Dinitrate; Lipid Peroxidation; Platelet Activation; Rats; Rats, Wistar; Thromboxane A2; Vasoconstriction | 2005 |
Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cyclic GMP; Drug Resistance, Neoplasm; Female; Humans; Isosorbide Dinitrate; Male; Mice; Neoplasms, Experimental; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Prostatic Neoplasms; Signal Transduction | 2007 |
LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation.
Topics: Animals; Blood Pressure; Caveolin 3; Cyclic GMP; Fibrosis; HSP90 Heat-Shock Proteins; Hypertrophy, Left Ventricular; Isosorbide Dinitrate; Male; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2007 |
Combined use of PDE5 inhibitors and nitrates in the treatment of pulmonary arterial hypertension in patients with heart failure.
Topics: Cyclic GMP; Drug Therapy, Combination; Heart Failure; Humans; Hypertension, Pulmonary; Isosorbide Dinitrate; Male; Middle Aged; Nitro Compounds; Nitroglycerin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2009 |
The role of nitric oxide in the expression of renal aquaporin 2 in a cirrhotic rat model: does an AVP-independent mechanism exist for the regulation of AQP2 expression?
Topics: Analysis of Variance; Animals; Aquaporin 2; Biopterins; Cyclic GMP; Disease Models, Animal; Immunoenzyme Techniques; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Statistics, Nonparametric; Thioacetamide | 2010 |
Differences between nitrates: role of isosorbide 2-mononitrate.
Topics: Animals; Aorta; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitroglycerin; Perfusion; Rabbits; Vasodilation; Vasodilator Agents | 2010 |
Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression.
Topics: Animals; Aorta; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Isosorbide Dinitrate; Male; Mice; Mice, Knockout; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Superoxides | 2013 |
Role of both actin-myosin cross bridges and NO-cGMP pathway modulators in the contraction and relaxation of human placental stem villi.
Topics: Actins; Chorionic Villi; Cyclic GMP; Diacetyl; Electric Stimulation; Enzyme Inhibitors; Female; Heterocyclic Compounds, 4 or More Rings; Humans; In Vitro Techniques; Isosorbide Dinitrate; Kinetics; Myosins; Nitric Oxide; Nitric Oxide Donors; Piperazines; Pliability; Potassium Chloride; Pregnancy; Protein Structure, Quaternary; Purines; Second Messenger Systems; Sildenafil Citrate; Sulfones; Term Birth | 2013 |
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Blood Platelets; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Humans; Hypotension; Isosorbide Dinitrate; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Thrombin; Tyrosine; Vasodilator Agents | 2014 |