isosorbide-2-mononitrate has been researched along with isosorbide-5-mononitrate in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (68.25) | 18.7374 |
| 1990's | 17 (26.98) | 18.2507 |
| 2000's | 1 (1.59) | 29.6817 |
| 2010's | 2 (3.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atanassova, R; Balansky, R; Boev, K; Spassov, G | 1 |
| Werkö, L | 1 |
| Fung, HL; Tzeng, TB | 3 |
| Keller-Stanislawski, B; Marschner, JP; Rietbrock, N | 1 |
| Araki, Y; Furuno, K; Gomita, Y | 4 |
| Bennett, BM; Booth, BP; Brien, JF; Elliott, DA; Marks, GS; McCans, JL; Nakatsu, K | 1 |
| Bernini, W; De Caterina, R; Giannessi, D; Lazzerini, G; Lombardi, M; Mazzone, A; Moscarelli, E; Weiss, M | 1 |
| Heidemann, R; Kaltenbach, M; Menke, G; Rietbrock, N; Satter, P; Schneider, W | 1 |
| Bernini, W; De Caterina, R; Giannessi, D; Mazzone, A | 2 |
| Bernini, W; De Caterina, R; Giannessi, D; Lazzerini, G; Lombardi, M; Mazzone, A | 1 |
| Liu, WY | 1 |
| Boertz, A; Bonn, R; Cawello, W; Dickmans, HA; Evers, J; Weiss, M | 1 |
| Fay, L; Michel, G; Prost, M | 1 |
| Berenger, FP; Cano, JP; Rolland, PH | 1 |
| Bogaert, MG | 2 |
| Bogaert, MG; Bouckaert, J; Lefebvre, RA; Rosseel, MT | 1 |
| Laufen, H; Leitold, M; Wildfeuer, A | 1 |
| Eckel, L; Kaltenbach, M; Kober, G; Schneider, W; von Loh, D | 1 |
| Berenger, FP; Bodard, H; Friggi, A; Rolland, PH | 1 |
| Menke, G; Rietbrock, N; Schnellhammer, R | 1 |
| Burkhardt, H; Deuster, U; Loew, D; Rietbrock, N | 1 |
| Cano, JP; Frances, Y; Iliadis, A; Luccioni, R; Santoni, Y | 1 |
| Bacher, S; Beck, A; Kraupp, O; Raberger, G; Skoda, H | 1 |
| Knoll, J; Menke, G; Merz, PG; Rietbrock, N | 1 |
| Abshagen, U; Betzien, G; Endele, R; Kaufmann, B; Neugebauer, G | 1 |
| Galeazzi, RL; Straehl, P | 1 |
| Blasini, R; Brügmann, U; Reiniger, G; Rudolph, W | 1 |
| Fung, HL | 1 |
| Bussmann, WD | 1 |
| Fung, HL; Morrison, RA | 2 |
| Galeazzi, RL; Soliva, M; Straehl, P | 1 |
| Bennett, BM; Brien, JF; Marks, GS; Nakatsu, K; Tam, GS; Van Alstyne, K | 1 |
| Georgieva, R; Mikhaĭlova, D; Naplatanova, D; Ognianova, V; Velikova, E | 1 |
| Chasseaud, LF; Darragh, A; Doyle, E; Lambe, RF; Taylor, T | 1 |
| Bogaert, MG; Bruyneel, K; Rosseel, MT | 2 |
| Aumann, M; Laufen, H; Leitold, M | 1 |
| Pommier, F; Sioufi, A | 1 |
| Cano, JP; Rolland, PH; Santoni, Y | 1 |
| Chasseaud, LF; Major, RM; Taylor, IW; Taylor, T | 1 |
| Kochsiek, K; Schanzenbächer, P | 1 |
| Degen, J; Geigenberger, A; Maier-Lenz, H | 1 |
| Kimura, T; Kogi, K; Saito, T; Tanaka, O | 1 |
| Dietmann, K; Sponer, G; Voss, E | 1 |
| Bartsch, W; Dietmann, K; Strein, K | 1 |
| Bussmann, WD; Kaltenbach, M; Reifart, F; Reifart, N | 1 |
| Mukerjee, N; Pietruszko, R | 1 |
| Bonn, R; Fritschi, E; Hutt, V; Lutz, D; Pabst, G; Theodor, R | 1 |
| Araki, I; Hashimoto, Y; Kimura, F; Kou, H; Kushikata, T; Matsuki, A; Murakawa, T; Sato, T; Takagi, H | 1 |
| Andersson, A; Bröijersén, A; Hjemdahl, P; Larsson, PT; Wallén, NH | 1 |
| Buchberger, D; Häring, N; Läuter, J; Metzner, JE | 1 |
| David, V; Medvedovici, A; Udrescu, S | 1 |
| Bonadei, I; Caretta, G; Cas, LD; Raddino, R; Teli, M; Vizzardi, E | 1 |
| Guo, J; Guo, R; Jiang, Z; Li, R; Sun, Z; Wei, C; Yuan, G; Zhang, R | 1 |
4 review(s) available for isosorbide-2-mononitrate and isosorbide-5-mononitrate
| Article | Year |
|---|---|
[Tolerance in treatment with nitrates].
Topics: Drug Tolerance; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Risk Factors | 1992 |
Pharmacokinetics of organic nitrates in man: an overview.
Topics: Absorption; Administration, Cutaneous; Administration, Sublingual; Humans; Injections, Intravenous; Isosorbide Dinitrate; Nitroglycerin | 1988 |
[Acute and long-term nitrate treatment of angina pectoris].
Topics: Acute Disease; Administration, Oral; Angina Pectoris; Bandages; Drug Tolerance; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Long-Term Care; Mouth Floor; Nitroglycerin; Ointments | 1983 |
Clinical pharmacokinetics of nitrates.
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Administration Routes; Half-Life; Humans; Isosorbide Dinitrate; Liver; Nitrates; Nitroglycerin; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1994 |
11 trial(s) available for isosorbide-2-mononitrate and isosorbide-5-mononitrate
| Article | Year |
|---|---|
[Pharmacokinetics of low-dose isosorbide dinitrate and metabolites after buccal or oral administration].
Topics: Administration, Buccal; Administration, Oral; Adult; Biological Availability; Blood Pressure; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male | 1992 |
Inhibition of platelet function during in vivo infusion of isosorbide mononitrates: relationship between plasma drug concentration and hemodynamic effects.
Topics: Coronary Disease; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1990 |
In vivo actions of organic nitrates on platelet function in humans.
Topics: Dose-Response Relationship, Drug; Epoprostenol; Humans; Isosorbide Dinitrate; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Vasodilator Agents | 1989 |
[Dose-dependent serum concentration of ISDN and its metabolites following administration of ISDN-retard. Studies under steady-state conditions].
Topics: Aged; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Random Allocation | 1986 |
[Bioavailability of isosorbide dinitrate and isosorbide-5-mononitrate under steady-state conditions].
Topics: Adult; Biological Availability; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Male; Random Allocation | 1985 |
Is isosorbide mononitrate better than the dinitrate?
Topics: Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Humans; Isosorbide Dinitrate | 1984 |
[Prevention of the development of tolerance to isosorbide dinitrate in interval therapy].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Heart Rate; Humans; Isosorbide Dinitrate | 1984 |
[Comparison of the anti-angina effect and effect duration of isosorbide dinitrate, isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN)].
Topics: Angina Pectoris; Delayed-Action Preparations; Hemodynamics; Humans; Isosorbide Dinitrate; Male | 1981 |
Bioavailability and pharmacokinetics of a new isosorbide dinitrate spray preparation in healthy volunteers.
Topics: Adolescent; Adult; Aerosols; Biological Availability; Chromatography, Gas; Humans; Isosorbide Dinitrate; Male; Therapeutic Equivalency | 1993 |
Effects of an oral dose of isosorbide dinitrate on platelet function and fibrinolysis in healthy volunteers.
Topics: Administration, Oral; Adult; beta-Thromboglobulin; Blood Platelets; Blood Pressure; Double-Blind Method; Epinephrine; Fibrinolysis; Heart Rate; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Platelet Aggregation; Vasodilation | 1993 |
[Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation].
Topics: Adult; Biological Availability; Cross-Over Studies; Female; Humans; Isosorbide Dinitrate; Male; Tablets; Therapeutic Equivalency; Vasodilator Agents | 1997 |
48 other study(ies) available for isosorbide-2-mononitrate and isosorbide-5-mononitrate
| Article | Year |
|---|---|
Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of the guinea-pig and dog.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dogs; Guinea Pigs; Heart; In Vitro Techniques; Isosorbide Dinitrate; Myocardial Contraction; Vasodilator Agents | 1992 |
Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.
Topics: Animals; Blood Pressure; Injections, Intravenous; Isosorbide Dinitrate; Male; Mathematics; Rats; Rats, Inbred Strains; Vasodilation | 1992 |
Influence of standard and nicotine-reduced cigarette smoke on plasma concentrations of isosorbide dinitrate and its metabolites in rats.
Topics: Animals; Chromatography, Gas; Isosorbide Dinitrate; Male; Nicotine; Rats; Rats, Inbred Strains; Smoking | 1991 |
Gas chromatographic analysis of isomeric organic mononitrates in plasma.
Topics: Animals; Chromatography, Gas; Isomerism; Isosorbide Dinitrate; Nitrates; Rats | 1991 |
Assay of glyceryl trinitrate, isosorbide dinitrate, and their metabolites in plasma by large-bore capillary column gas-liquid chromatography.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Nitroglycerin | 1990 |
Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.
Topics: Animals; Electroshock; Foot; Injections, Intraperitoneal; Isosorbide Dinitrate; Male; Rats; Reference Values; Stress, Psychological | 1990 |
Concentrations of isosorbide dinitrate, isosorbide-2-mononitrate and isosorbide-5-mononitrate in human vascular and muscle tissue under steady-state conditions.
Topics: Aged; Chromatography, Gas; Humans; Isosorbide Dinitrate; Male; Middle Aged; Muscle, Smooth, Vascular; Muscles | 1990 |
Mechanisms for the in vivo antiplatelet effects of isosorbide dinitrate.
Topics: Adult; Epoprostenol; Female; Humans; Iloprost; In Vitro Techniques; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboxane B2 | 1988 |
[Determination of isosorbide dinitrate and its degradation products in pharmaceuticals by gradient RP-HPLC].
Topics: Chromatography, High Pressure Liquid; Isosorbide Dinitrate | 1989 |
Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Kidney Failure, Chronic; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged | 1989 |
Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate orally administered to rats.
Topics: Administration, Oral; Animals; Electroshock; Isosorbide Dinitrate; Male; Rats; Rats, Inbred Strains; Stress, Psychological | 1989 |
Determination of isosorbide dinitrate and its metabolites in plasma by gas chromatography on a capillary column with electron-capture detection.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Reference Standards | 1989 |
Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate subcutaneously administered to rats.
Topics: Animals; Chromatography, Gas; Electroshock; Injections, Subcutaneous; Isosorbide Dinitrate; Male; Rats; Rats, Inbred Strains; Stress, Psychological; Temperature | 1989 |
In vitro evidence of an endothelial cell-dependent antiplatelet activity for isosorbide dinitrate, but not for its 2- and 5-mononitrate metabolites.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Cell Extracts; Cells, Cultured; Dinoprostone; Endothelium; Female; Humans; Isosorbide Dinitrate; Male; Platelet Aggregation; Prostaglandins E; Thromboxane B2; Tissue Extracts | 1987 |
Influence of exercise on plasma concentrations of isosorbide dinitrate.
Topics: Administration, Oral; Adult; Female; Humans; Isosorbide Dinitrate; Male; Physical Exertion; Rest | 1988 |
Comparative pharmacokinetics of isosorbide nitrates after repeated doses of sustained release isosorbide dinitrate.
Topics: Adult; Delayed-Action Preparations; Female; Half-Life; Humans; Isosorbide Dinitrate; Male; Tablets | 1988 |
Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates.
Topics: Adult; Blood Platelets; Drug Synergism; Epoprostenol; Female; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Nitrates; Platelet Aggregation; Thromboxane B2 | 1988 |
Dose-dependent relaxation of human venous vessel strips with regard to chronic nitrate pretreatment.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Humans; In Vitro Techniques; Isosorbide Dinitrate; Saphenous Vein; Vasodilation | 1988 |
Control of the anti-thrombogenic endothelial cell defense by short- and long-term exposure of cultured endothelial cells to isosorbide nitrates.
Topics: Animals; Cattle; Endothelium, Vascular; Humans; In Vitro Techniques; Isosorbide Dinitrate; Platelet Adhesiveness; Platelet Aggregation; Time Factors | 1988 |
[Concentration-time profile of isosorbide dinitrate and its metabolites in plasma following percutaneous resorption of a transdermal therapeutic system].
Topics: Administration, Cutaneous; Adult; Biological Availability; Female; Humans; Isosorbide Dinitrate; Male; Time Factors | 1987 |
Pharmacokinetics of isosorbide dinitrate and its mononitrate metabolites after intravenous infusion.
Topics: Adult; Aged; Female; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Models, Biological | 1986 |
Characterization of vasodilators by comparison of their effects on blood pressure, counterregulation and myocardial oxygen demand in conscious normotensive dogs.
Topics: Animals; Blood Pressure; Dihydralazine; Dogs; Female; Heart Rate; Isosorbide Dinitrate; Labetalol; Male; Molsidomine; Myocardium; Oxygen Consumption; Piperazines; Prazosin; Pyridazines; Renin; Sydnones; Vasodilator Agents | 1985 |
Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration.
Topics: Administration, Oral; Biological Availability; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Kinetics; Male; Models, Biological | 1985 |
Isosorbide dinitrate bioavailability, kinetics, and metabolism.
Topics: Administration, Oral; Adult; Biological Availability; Humans; Injections, Intravenous; Isosorbide Dinitrate; Kinetics; Male; Models, Biological; Mouth Floor; Tablets | 1985 |
Pharmacokinetics of nitroglycerin and long-acting nitrate esters.
Topics: Absorption; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Kinetics; Nitrates; Nitroglycerin | 1983 |
Determination of the partitioning, stability, and metabolite formation of isosorbide dinitrate in human and rat blood using an improved gas-liquid chromatographic assay.
Topics: Animals; Chromatography, Gas; Drug Stability; Humans; Isosorbide Dinitrate; Kinetics; Male; Nitroglycerin; Rats; Rats, Inbred Strains; Solubility | 1984 |
Isosorbide 5-mononitrate and isosorbide 2-mononitrate kinetics after intravenous and oral dosing.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Female; Half-Life; Humans; Infusions, Parenteral; Injections, Intravenous; Isosorbide Dinitrate; Kinetics; Male | 1984 |
Isosorbide dinitrate disposition in the rat: metabolite pharmacokinetics and interactions.
Topics: Animals; Half-Life; Isosorbide Dinitrate; Kinetics; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains | 1984 |
Effect of 5-isosorbide mononitrate on isosorbide dinitrate-induced relaxation of rabbit aortic rings.
Topics: Animals; Aorta; Dose-Response Relationship, Drug; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle Relaxation; Rabbits; Vasodilation | 1984 |
[Pharmacokinetics of isodinit (from Pharmachem) in humans].
Topics: Adult; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Middle Aged; Tablets | 1984 |
Bioavailability of isosorbide dinitrate and its two mononitrate metabolites from sustained-release formulations.
Topics: Adolescent; Adult; Biological Availability; Delayed-Action Preparations; Half-Life; Humans; Isosorbide Dinitrate; Male | 1983 |
Single administration of atenolol does not influence the kinetics of orally given isosorbide dinitrate.
Topics: Administration, Oral; Adult; Aged; Atenolol; Humans; Isosorbide Dinitrate; Kinetics | 1983 |
Oral absorption and disposition of isosorbide dinitrate and isosorbide mononitrates in man.
Topics: Administration, Oral; Adult; Female; Humans; Intestinal Absorption; Isosorbide Dinitrate; Kinetics; Male; Middle Aged | 1983 |
Determination of the two mononitrate metabolites of isosorbide dinitrate in human plasma and urine by gas chromatography with electron-capture detection.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Hydrolysis; Isosorbide Dinitrate; Male; Time Factors | 1984 |
Determination of isosorbide dinitrate and its mononitrate metabolites in human plasma using Extrelut purification and capillary column gas-liquid chromatography.
Topics: Chromatography, Gas; Humans; Isosorbide Dinitrate; Kinetics | 1984 |
Saliva concentrations of isosorbide dinitrate, isosorbide 2-mononitrate and isosorbide 5-mononitrate.
Topics: Adult; Humans; Isosorbide Dinitrate; Male; Saliva | 1984 |
[Isosorbide mononitrate or dinitrate in coronary disease?].
Topics: Coronary Disease; Humans; Isosorbide Dinitrate | 1983 |
Plasma concentrations of isosorbide dinitrate and mononitrates after acute and chronic oral administration of isosorbide dinitrate in man.
Topics: Administration, Oral; Aged; Biotransformation; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Time Factors | 1982 |
[Comparative pharmacokinetics and bioavailability of isosorbide dinitrate and its metabolites isosorbide 5- and 2-mononitrate from delayed-release preparations].
Topics: Adult; Biological Availability; Delayed-Action Preparations; Female; Humans; Isosorbide Dinitrate; Kinetics; Male | 1982 |
[Hemodynamic effects of a transdermal formulation of isosorbide dinitrate and its pharmacokinetics in conscious dogs].
Topics: Administration, Topical; Animals; Delayed-Action Preparations; Dogs; Female; Hemodynamics; Isosorbide Dinitrate; Kinetics; Skin Absorption | 1982 |
[Pharmacodynamics, pharmacokinetics and metabolism of isosorbide nitrates in the awake dog].
Topics: Animals; Dogs; Hemodynamics; Isosorbide; Isosorbide Dinitrate | 1981 |
[Nitrite and methemoglobin formation in dogs following oral isosorbide dinitrate, isosorbide-2-mononitrate and isosorbide-5-mononitrate].
Topics: Animals; Dogs; Female; Isosorbide Dinitrate; Male; Methemoglobin; Nitrites | 1981 |
Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate.
Topics: Aldehyde Dehydrogenase; Chloral Hydrate; Enzyme Reactivators; Esterases; Humans; Isoenzymes; Isosorbide Dinitrate; Mercaptoethanol; NAD; Oxidoreductases | 1994 |
Pharmacokinetics of stereomeric 1,4:3,6-dianhydrohexitol mononitrates in rats.
Topics: Animals; Injections, Intravenous; Isosorbide Dinitrate; Male; Nitrates; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sugar Alcohols; Vasodilator Agents | 1993 |
[Plasma levels of isosorbide dinitrate and its metabolites during intravenous infusion in surgical patients--effect of preoperative administration of isosorbide dinitrate].
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Neuroleptanalgesia; Preanesthetic Medication; Surgical Procedures, Operative | 1993 |
Effect of large volume injection of hydrophobic solvents on the retention of less hydrophobic pharmaceutical solutes in RP-LC.
Topics: Chromatography, Liquid; Heptanes; Hexanes; Hydrophobic and Hydrophilic Interactions; Isosorbide Dinitrate; Molecular Structure; Octanes; Parabens; Pentoxifylline; Sensitivity and Specificity; Solubility; Solvents; Tropicamide | 2008 |
Differences between nitrates: role of isosorbide 2-mononitrate.
Topics: Animals; Aorta; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitroglycerin; Perfusion; Rabbits; Vasodilation; Vasodilator Agents | 2010 |
A simple and sensitive gas chromatography method for determination of isosorbide dinitrate and its metabolites in human plasma: application to pharmacokinetics study on oral spray.
Topics: Administration, Oral; Adult; Drug Stability; Humans; Isosorbide Dinitrate; Male | 2014 |