isoshinanolone and tachioside

To study the anti-oxidative constituents of the aerial parts of Plumbago zeylanica.. The ethanol extract of Plumbago zeylanica was separated and purified by various chromatographic techniques. On the basis of various spectroscopic data, the structures of isolated compounds were elucidated. ABTS+radical scavenging were carried out in antioxidant activity evaluation of the isolated compounds.. Eleven compounds were isolated and identified as cis-isoshinanolone-4-O-β-D-glucopyranoside( 1),tachioside( 2),2,6-dimethoxy-p-hydroquinone-1-O-β-D-glucopyranoside( 3),3-( β-D-glucopyranosyloxy)-4-methoxybenzoic acid( 4),3’-O-β-D-glucopyranosyloxy-plumbagic acid( 5),3’-O-β-D-glucopyranosyloxy-plumbagic acid methyl ester( 6),plumbagic acid( 7),plumbagine A( 8),plumbagine C( 9),syringate-4-O-β-D-glucopyranoside( 10) and 2-methyl-5-hydroxychromone( 11). Compounds 2,3,and5 displayed significant scavenging effect on ABTS+.. Compounds 1 ~ 4,10,11 are obtained from this plant for the first time. Compounds 2,3,and 5 show significant anti-oxidative effects.

Topics: Drugs, Chinese Herbal; Glycosides; Plant Components, Aerial; Plumbaginaceae; Tetrahydronaphthalenes