isosafrole and sesamol

isosafrole has been researched along with sesamol* in 1 studies

Other Studies

1 other study(ies) available for isosafrole and sesamol

Article	Year
Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. Biochemical pharmacology, 1985, Mar-01, Volume: 34, Issue:5 Eighteen methylenedioxyphenyl (MDP) compounds, including some commonly inhaled by people, were tested for the ability to inhibit rabbit nasal microsomal cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase. For comparison, liver microsomes were also used. Nasal cytochrome P-450 from rabbits metabolized MDP compounds to form cytochrome P-450-metabolite (P-450-MI) complexes as indicated by difference spectra in the Soret region. Several of the MDP compounds were potent inhibitors of nasal P-450-dependent N-demethylase. If inhibition of nasal P-450 also occurs in vivo after inhibiting MDP compounds are inhaled, the metabolism of concurrently or subsequently inhaled compounds may be altered. Topics: Animals; Benzaldehydes; Benzodioxoles; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Dealkylation; Dioxoles; Liver; Male; Nose; Oxidoreductases, N-Demethylating; Phenols; Piperonyl Butoxide; Rabbits; Safrole	1985

Article

Year

Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds.

Biochemical pharmacology, 1985, Mar-01, Volume: 34, Issue:5

Eighteen methylenedioxyphenyl (MDP) compounds, including some commonly inhaled by people, were tested for the ability to inhibit rabbit nasal microsomal cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase. For comparison, liver microsomes were also used. Nasal cytochrome P-450 from rabbits metabolized MDP compounds to form cytochrome P-450-metabolite (P-450-MI) complexes as indicated by difference spectra in the Soret region. Several of the MDP compounds were potent inhibitors of nasal P-450-dependent N-demethylase. If inhibition of nasal P-450 also occurs in vivo after inhibiting MDP compounds are inhaled, the metabolism of concurrently or subsequently inhaled compounds may be altered.

Topics: Animals; Benzaldehydes; Benzodioxoles; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Dealkylation; Dioxoles; Liver; Male; Nose; Oxidoreductases, N-Demethylating; Phenols; Piperonyl Butoxide; Rabbits; Safrole

1985