isoproterenol has been researched along with transforming growth factor beta in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (23.40) | 18.2507 |
| 2000's | 13 (27.66) | 29.6817 |
| 2010's | 13 (27.66) | 24.3611 |
| 2020's | 10 (21.28) | 2.80 |
| Authors | Studies |
|---|---|
| Piper, HM; Schlüter, KD; Zhou, XJ | 1 |
| Hartogensis, WE; Long, CS; Simpson, PC | 1 |
| Balligand, JL; Kelly, RA; Kobzik, L; Kunkel, SL; Lowenstein, CJ; Michel, T; Okada, I; Simmons, WW; Smith, TW; Ungureanu-Longrois, D | 1 |
| Bansal, DD; Klein, RM; MacGregor, RR | 1 |
| Iizuka, K; Kawaguchi, H; Kitabatake, A; Murakami, T | 1 |
| Iwao, H; Kim, S; Omura, T; Takeda, T; Takeuchi, K | 1 |
| Iizuka, K; Kawaguchi, H; Kitabatake, A; Sano, H | 1 |
| Nogami, M; Rennard, SI; Romberger, DJ; Toews, ML | 1 |
| Armstead, WM; Leffler, CW; Mirro, R; Shibata, M; Zuckerman, SL | 1 |
| Ferrell, JB; Fleisher, LN; McGahan, MC; Pagan, I | 1 |
| Annoni, G; Arosio, B; Fiordaliso, F; Gagliano, N; Latini, R; Luvarà, G; Masson, S; Santambrogio, D; Vergani, C | 1 |
| Annoni, G; Arosio, B; Calvillo, L; D'Aquila, S; Fiordaliso, F; Gagliano, N; Latini, R; Masson, S; Santambrogio, D; Vergani, C | 1 |
| Flesch, M; Frischkopf, K; Piper, HM; Rosenkranz, S; Schlüter, KD; Taimor, G | 1 |
| Barth, W; Choate, J; Dixon, PS; Helal, K; Shenberger, JS; Shew, RL | 1 |
| Calderone, A; Colombo, F; Mayers, P; Mercier, I; Noël, J | 1 |
| O'Callaghan, CJ; Williams, B | 1 |
| Ishikawa, T; Ito, Y; Kondo, M; Kume, H; Shimokata, K; Yamaki, K | 1 |
| Bradbury, D; Clayton, A; El-Haroun, H; Knox, AJ | 1 |
| Barksdale, AR; Bernard, AC; Boulanger, BR; Gellin, GL; Kearney, PA; Maley, ME; Ochoa, JB; Tsuei, BJ | 1 |
| Schlüter, KD; Soltanpour, G; Wenzel, S | 1 |
| Lynch, GS; Maxwell, MA; Muscat, GE; Ohkura, N; Pearen, MA; Ryall, JG | 1 |
| Baker, KM; Kumar, R; Singh, VP | 1 |
| André, S; Carretero, OA; D'Ambrosio, M; Gabius, HJ; Liao, TD; Liu, YH; Peng, H; Rhaleb, NE; Sharma, U | 1 |
| Fraser, I; Han, H; Hsueh, RC; Jiang, LI; Liu, J; Mumby, S; Natarajan, M; Pond, B; Simon, MI; Sternweis, PC; Taussig, R | 1 |
| Azevedo, I; Calhau, C; Faria, A; Monteiro, R; Pestana, D; Teixeira, D | 1 |
| Calderone, A; El-Helou, V; Gosselin, H; Villeneuve, L | 1 |
| Marx, G; Rassler, B; Schierle, K; Zimmer, HG | 1 |
| Jiang, Y; Jing, W; Li, M; Miao, C; Ren, L; Sun, B | 1 |
| Gobe, GC; Johnson, DW; Martin, J; Morais, C; Small, DM; Vesey, DA | 1 |
| Chu, W; Ding, XQ; Dong, CJ; Ji, Y; Li, H; Li, YC; Li, YY; Liu, MT; Lou, J; Song, SY; Sun, F; Yu, CJ; Zhang, LL; Zhang, ZR; Zhao, D | 1 |
| Chen, SW; Chu, PH; Chu, Y; Jung, SM; Kao, WW; Lin, PJ; Tung, YC | 1 |
| Chen, Y; Cui, J; Liu, L; Ning, B; Zhang, T | 1 |
| Cai, J; Chen, L; Chen, X; Zheng, G; Zhou, H; Zhou, X | 1 |
| Ma, ZG; Tang, QZ; Wang, SS; Xu, SC; Yuan, YP; Zhang, X | 1 |
| Akhtar, M; Akhtar, MS; Hassan, MQ; Iqbal, R; Jairajpuri, Z; Najmi, AK | 1 |
| Pugalendi, KV; Radhiga, T; Senthil, S; Sundaresan, A | 1 |
| Fan, XF; Gong, YS; Han, LP; Li, X; Liu, ZH; Wang, X; Zhang, Y | 1 |
| Feng, K; Tang, Y; Tao, R; Wei, Y; Wu, Y; Xu, H; Zhao, Y | 1 |
| He, Y; Hu, H; Jiang, P; Liu, G; Liu, X; Ouyang, F; Qiu, H | 1 |
| Chen, Y; Meng, Q; Sun, D; Yao, X; Zhan, K; Zhang, X; Zhao, Y; Zhu, L | 1 |
| Rabbani, S; Soltani, BM; Yousefi, F | 1 |
| Chen, D; Chu, J; Gao, H; Huang, B; Lin, S; Lu, Y; Peng, J; Peng, M; Shen, A; Shen, Z; Xie, L; Yang, M | 1 |
| Ahn, Y; Jeong, A; Kim, YK; Kook, H; Kook, T; Kwon, DH; Lee, YU; Lim, Y; Park, WJ | 1 |
| Chen, K; Li, Z; Zhu, YZ | 1 |
| Adu-Amankwaah, J; An, K; Cui, J; Lin, L; Song, N; Sun, H; Tan, R; Wang, M; You, Q; Yuan, J | 1 |
| Gari, M; Kumar Mariappan, A; Kumar, A; Kumar, D; Kumar, T; Lingaraju, MC; Parida, S; Rana, A; Sharma, M; Singh, TU | 1 |
| Feng, Y; He, J; Li, D; Peng, C; Xing, Z; Yang, C | 1 |
47 other study(ies) available for isoproterenol and transforming growth factor beta
| Article | Year |
|---|---|
Induction of hypertrophic responsiveness to isoproterenol by TGF-beta in adult rat cardiomyocytes.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cattle; Cells, Cultured; Culture Media; Isoproterenol; Male; Myocardium; Rats; Time Factors; Transforming Growth Factor beta | 1995 |
Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Betaxolol; Cardiomegaly; Cell Division; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; DNA; Growth Substances; Heart; Isoproterenol; Myocardium; Phenylephrine; Propranolol; Rats; Receptors, Adrenergic, beta; RNA, Messenger; Transforming Growth Factor beta | 1993 |
Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture.
Topics: Amino Acid Oxidoreductases; Animals; Cells, Cultured; Endothelium, Vascular; Heart Ventricles; Interleukin-1; Isoproterenol; Lipopolysaccharides; Male; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 1995 |
Secretion of plasminogen activator activity from neonatal rat heart cells is regulated by hormones and growth factors.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Endothelins; Fibroblasts; Heart; Hormones; Humans; Hydrocortisone; Isoproterenol; Kinetics; Myocardium; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Tissue Plasminogen Activator; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator | 1995 |
Effect of transforming growth factor beta-1 on the intracellular calcium in cardiac fibroblasts.
Topics: Animals; Calcium; Cyclic AMP; Fibroblasts; Isoproterenol; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Transforming Growth Factor beta | 1995 |
Transforming growth factor beta 1 and extracellular matrix gene expression in isoprenaline induced cardiac hypertrophy: effects of inhibition of the renin-angiotensin system.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Northern; Cardiomegaly; Collagen; Extracellular Matrix; Fibronectins; Gene Expression; Indans; Isoproterenol; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta | 1994 |
Transforming growth factor beta-1 modulates the number of beta-adrenergic receptors in cardiac fibroblasts.
Topics: Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Fibroblasts; Isoproterenol; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Transforming Growth Factor beta | 1994 |
TGF-beta 1 modulates beta-adrenergic receptor number and function in cultured human tracheal smooth muscle cells.
Topics: Adenylyl Cyclases; Cells, Cultured; Cyclic AMP; Cycloheximide; Fluorides; Humans; Intracellular Membranes; Isoproterenol; Muscle, Smooth; Receptors, Adrenergic, beta; Trachea; Transforming Growth Factor beta | 1994 |
Transforming growth factor-beta attenuates ischemia-induced alterations in cerebrovascular responses.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Dinoprostone; Female; Hypercapnia; Hypotension; Isoproterenol; Male; Swine; Transforming Growth Factor beta; Vasodilation | 1993 |
Interleukin-1 beta increases prostaglandin E2-stimulated adenosine 3',5'-cyclic monophosphate production in rabbit pigmented ciliary epithelium.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Interleukin-1; Isoproterenol; Kinetics; Lipopolysaccharides; Pigment Epithelium of Eye; Protein Synthesis Inhibitors; Rabbits; Stimulation, Chemical; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation; Vasoactive Intestinal Peptide | 1996 |
Remodelling of cardiac extracellular matrix during beta-adrenergic stimulation: upregulation of SPARC in the myocardium of adult rats.
Topics: Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; Collagen; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Heart; Heart Ventricles; Isoproterenol; Male; Myocardium; Osteonectin; Rats; Rats, Wistar; Transforming Growth Factor beta; Up-Regulation | 1998 |
Left ventricular response to beta-adrenergic stimulation in aging rats.
Topics: Adaptation, Physiological; Adrenergic beta-Agonists; Aging; Analysis of Variance; Animals; Atrial Natriuretic Factor; Blotting, Northern; Cardiomegaly; Collagen; Gene Expression Regulation; Heart Rate; Isoproterenol; Male; Myocardium; Rats; Rats, Wistar; Transforming Growth Factor beta; Up-Regulation; Ventricular Function, Left | 2000 |
Central role for ornithine decarboxylase in beta-adrenoceptor mediated hypertrophy.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Enzyme Activation; Isoproterenol; Male; Myocardium; Ornithine Decarboxylase; Perfusion; Phenylalanine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stimulation, Chemical; Transforming Growth Factor beta | 2000 |
Pregnancy and labor increase the capacity of human myometrial cells to secrete parathyroid hormone-related protein.
Topics: Adult; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Isoproterenol; Labor, Obstetric; Myometrium; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Pregnancy; Proteins; Transforming Growth Factor beta | 2001 |
beta-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of phosphatidylinositol 3-kinase.
Topics: Adrenergic beta-Agonists; Angiotensin II; Animals; Cell Division; Cells, Cultured; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Isoproterenol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Tyrphostins | 2001 |
The regulation of human vascular smooth muscle extracellular matrix protein production by alpha- and beta-adrenoceptor stimulation.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibronectins; Humans; Isoproterenol; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Propranolol; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Inhibitory effects of interferon-gamma on the heterologous desensitization of beta-adrenoceptors by transforming growth factor-beta 1 in tracheal smooth muscle.
Topics: Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Female; Guinea Pigs; In Vitro Techniques; Interferon-gamma; Isoproterenol; Methacholine Chloride; Muscle, Smooth; Receptors, Adrenergic, beta; Trachea; Transforming Growth Factor beta | 2003 |
Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation o
Topics: Adenylyl Cyclases; Adult; Arachidonic Acid; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Induction; Epoprostenol; Gene Expression Regulation, Enzymologic; Growth Substances; Humans; Interleukin-1; Isoenzymes; Isoproterenol; Membrane Proteins; Muscle, Smooth, Vascular; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pulmonary Artery; RNA, Messenger; Sulfonamides; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Regulation of arginase expression by T-helper II cytokines and isoproterenol.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Arginase; Blotting, Western; Cell Line; Cytokines; Drug Synergism; Enzyme Induction; Interleukin-10; Interleukin-13; Interleukin-4; Isoproterenol; Macrophages; Reverse Transcriptase Polymerase Chain Reaction; Th2 Cells; Transforming Growth Factor beta | 2004 |
No correlation between the p38 MAPK pathway and the contractile dysfunction in diabetic cardiomyocytes: hyperglycaemia-induced signalling and contractile function.
Topics: Animals; Antioxidants; Ascorbic Acid; Cells, Cultured; Diabetes Mellitus; Electrophysiology; Glucose; Hyperglycemia; Imidazoles; Isoproterenol; Male; Muscle Contraction; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Adrenergic, beta; Signal Transduction; Transforming Growth Factor beta | 2005 |
The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Homeostasis; Ion Channels; Isoproterenol; Lipid Metabolism; Mice; Mitochondrial Proteins; Muscle Development; Muscle, Skeletal; Myostatin; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Promoter Regions, Genetic; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Receptors, Thyroid Hormone; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Uncoupling Protein 2; Uncoupling Protein 3 | 2006 |
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
Topics: Adrenergic beta-Agonists; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzazepines; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Fumarates; Glucose; Heart Ventricles; Isoproterenol; Microscopy, Confocal; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Tetrazoles; Time Factors; Transforming Growth Factor beta; Up-Regulation | 2008 |
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Body Weight; Cardiac Output; Cardiomegaly; Cardiotonic Agents; Collagen; Disease Models, Animal; Echocardiography, Doppler; Fibrosis; Galectin 3; Heart Rate; Hemodynamics; Inflammation; Infusions, Parenteral; Isoproterenol; Macrophages; Male; Mast Cells; Myocardial Contraction; Myocardium; Oligopeptides; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; Stroke Volume; Time Factors; Transforming Growth Factor beta; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Deciphering signaling outcomes from a system of complex networks.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Chemokine CCL3; Chemokine CCL5; Cytokines; Granulocyte Colony-Stimulating Factor; Interferon-beta; Interleukin-10; Interleukin-6; Isoproterenol; Macrophages; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sugar Acids; Time Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2009 |
Modulation of adipocyte biology by δ(9)-tetrahydrocannabinol.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiponectin; Animals; Cannabis; Dronabinol; Insulin; Insulin Resistance; Isoproterenol; Lipid Metabolism; Lipolysis; Lipoprotein Lipase; Mice; Phospholipase D; PPAR gamma; Proteins; Psychotropic Drugs; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta | 2010 |
The plating of rat scar myofibroblasts on matrigel unmasks a novel phenotype; the self assembly of lumen-like structures.
Topics: Actins; Animals; Carbocyanines; Cell Culture Techniques; Cell Differentiation; Cell Separation; Cells, Cultured; Cicatrix; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Drug Combinations; Endothelial Cells; Fibroblasts; Heart Ventricles; Intercellular Signaling Peptides and Proteins; Isoproterenol; Laminin; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myofibroblasts; Phenotype; Proteoglycans; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 2012 |
Catecholamines can induce pulmonary remodeling in rats.
Topics: Animals; Extracellular Matrix; Female; Isoproterenol; Matrix Metalloproteinase 2; Norepinephrine; Phenylephrine; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2012 |
Quercetin provides greater cardioprotective effect than its glycoside derivative rutin on isoproterenol-induced cardiac fibrosis in the rat.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Blotting, Western; Cardiotonic Agents; Endomyocardial Fibrosis; Extracellular Matrix; Glycosides; Heart Function Tests; Hemodynamics; Immunohistochemistry; Isoproterenol; Male; Myocardium; Organ Size; Quercetin; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Renin-Angiotensin System; Rutin; Transforming Growth Factor beta | 2013 |
Fibronectin and transforming growth factor beta contribute to erythropoietin resistance and maladaptive cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Cell Line; Erythropoietin; Fibronectins; Isoproterenol; Rats; Recombinant Proteins; Transforming Growth Factor beta | 2014 |
Type III Transforming Growth Factor-β Receptor Drives Cardiac Hypertrophy Through β-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II.
Topics: Analysis of Variance; Animals; beta-Arrestin 2; Biopsy, Needle; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Humans; Immunohistochemistry; Isoproterenol; Mice; Mice, Transgenic; Myocytes, Cardiac; Random Allocation; Sensitivity and Specificity; T-Box Domain Proteins; Transforming Growth Factor beta | 2016 |
Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis.
Topics: Animals; Apoptosis; Atrial Natriuretic Factor; Caspase 3; Chondroitin Sulfate Proteoglycans; Collagen Type I; Collagen Type III; Extracellular Matrix; Fibrosis; Heart; Homozygote; Isoproterenol; Keratan Sulfate; Lumican; Matrix Metalloproteinase 14; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phenotype; Polymerase Chain Reaction; Transforming Growth Factor beta | 2017 |
miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isoproterenol-induced myocardial fibrogenesis.
Topics: Animals; Cardiotonic Agents; Drugs, Chinese Herbal; Fibrosis; Isoproterenol; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardium; Saponins; Signal Transduction; Transforming Growth Factor beta | 2017 |
Anti-Fibrosis Effect of Relaxin and Spironolactone Combined on Isoprenaline-Induced Myocardial Fibrosis in Rats via Inhibition of Endothelial-Mesenchymal Transition.
Topics: Actins; Animals; Antigens, CD; Cadherins; Cardiotonic Agents; Collagen Type I; Collagen Type III; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Endomyocardial Fibrosis; Epithelial-Mesenchymal Transition; Human Umbilical Vein Endothelial Cells; Humans; Isoproterenol; Male; Myocardium; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Relaxin; Spironolactone; Transforming Growth Factor beta; Vimentin | 2017 |
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways.
Topics: Alkaloids; Angiotensin II; Anilides; Animals; Benzodioxoles; Cell Differentiation; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Heart; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts; Piperidines; Polyunsaturated Alkamides; PPAR gamma; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta | 2017 |
Pitavastatin ameliorates myocardial damage by preventing inflammation and collagen deposition via reduced free radical generation in isoproterenol-induced cardiomyopathy.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Collagen; Creatine Kinase, MB Form; Free Radicals; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Isoproterenol; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Myocardial Infarction; Myocardium; Natriuretic Peptide, Brain; Quinolines; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2019 |
Ursolic acid modulates MMPs, collagen-I, α-SMA, and TGF-β expression in isoproterenol-induced myocardial infarction in rats.
Topics: Actins; Animals; Cardiotonic Agents; Collagen Type I; Isoproterenol; Lysosomes; Male; Matrix Metalloproteinases; Mitochondria, Heart; Myocardial Infarction; Myocardium; Rats, Wistar; Transforming Growth Factor beta; Triterpenes; Ursolic Acid | 2019 |
SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition.
Topics: Animals; Cardiomegaly; Cell Line; Cell Nucleus; Collagen; Down-Regulation; Endothelium; Fibrosis; Isoproterenol; Male; Mesoderm; Mice, Inbred C57BL; Models, Biological; Myocardium; Phosphorylation; Protein Transport; Resveratrol; Sirtuin 1; Smad Proteins; Transforming Growth Factor beta | 2019 |
Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.
Topics: Animals; Animals, Newborn; Astragalus Plant; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease Models, Animal; Fibrosis; Humans; Isoproterenol; Male; Medicine, Chinese Traditional; MicroRNAs; Myocardium; Myofibroblasts; Plant Extracts; Plant Roots; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Triterpenes; TRPM Cation Channels | 2020 |
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Topics: Animals; Biomarkers; Biopsy; Cardiomyopathies; Disease Models, Animal; Disease Susceptibility; Extracellular Matrix; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Gene Silencing; Immunohistochemistry; Isoproterenol; MicroRNAs; Rats; RNA, Long Noncoding; Thrombospondin 1; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases | 2020 |
Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Collagen; Drugs, Chinese Herbal; Echocardiography; Extracellular Matrix; Fibrosis; Gene Expression; Isoproterenol; Male; Mice; Mitogen-Activated Protein Kinase Kinases; NIH 3T3 Cells; Oncogene Protein v-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2020 |
MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway.
Topics: 3' Untranslated Regions; Animals; Biomarkers; Cardiotonic Agents; Cells, Cultured; Fibrosis; Gene Expression Regulation; Humans; Isoproterenol; Male; Mice; MicroRNAs; Myofibroblasts; RNA Interference; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta | 2021 |
Huoxin Pill inhibits isoproterenol-induced transdifferentiation and collagen synthesis in cardiac fibroblasts through the TGF-β/Smads pathway.
Topics: Animals; Cardiotonic Agents; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Cell Transdifferentiation; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Fibrosis; Heart; Isoproterenol; Male; Myofibroblasts; Primary Cell Culture; Rats, Wistar; Signal Transduction; Smad Proteins; Tablets; Transcriptome; Transforming Growth Factor beta | 2021 |
P300/CBP-Associated Factor Activates Cardiac Fibroblasts by SMAD2 Acetylation.
Topics: Acetylation; Actins; Animals; Cell Movement; Cell Nucleus; Collagen Type I; Collagen Type I, alpha 1 Chain; Fibroblasts; Fibrosis; Humans; Isoproterenol; Male; Matrix Metalloproteinases; Mice, Inbred C57BL; Myocardium; p300-CBP Transcription Factors; Phosphorylation; Protein Transport; RNA, Messenger; Smad2 Protein; Transforming Growth Factor beta | 2021 |
Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway.
Topics: Animals; Cardiovascular Diseases; Fibrosis; Isoproterenol; Myocytes, Cardiac; Pyroptosis; Rats; Signal Transduction; Transforming Growth Factor beta | 2022 |
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.
Topics: Animals; Cardiomyopathies; Fibrosis; Heart Failure; Isoproterenol; Matrix Metalloproteinase 2; Mice; Molecular Docking Simulation; Myocardium; Myocytes, Cardiac; Takotsubo Cardiomyopathy; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2023 |
Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model.
Topics: Animals; Body Weight; Collagen; Fibrosis; Isoproterenol; Mice; Pravastatin; Transforming Growth Factor beta | 2023 |
Understanding aconite's anti-fibrotic effects in cardiac fibrosis.
Topics: Aconitum; Animals; Cardiomyopathies; Collagen; Fibrosis; Galactose; Isoproterenol; Myocardium; Rats; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2024 |