isoproterenol has been researched along with rolipram in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.45) | 18.7374 |
| 1990's | 30 (43.48) | 18.2507 |
| 2000's | 26 (37.68) | 29.6817 |
| 2010's | 11 (15.94) | 24.3611 |
| 2020's | 1 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Auld, DS; Austin, CP; Huang, R; Inglese, J; Leclair, CA; Maguire, W; Michnick, SW; Skoumbourdis, AP; Stefan, E; Thomas, CJ; Titus, SA; Turjanski, AG; Xia, M | 1 |
| Endoh, M; Katano, Y | 1 |
| Beleta, J; Berga, P; Bou, J; Cardelús, I; Fernández, AG; Gristwood, RW; Llenas, J | 1 |
| Carter, CM; Diocee, BK; Hassall, GA; Souness, JE; Turner, NC; Wood, LJ | 1 |
| Gaal, L; Illes, P; Schudt, C | 1 |
| Heaslip, R; Nielson, CP; Sturm, RJ; Vestal, RE | 1 |
| Bailey, IA; Kemp, PR; Radda, GK; Seymour, AM | 1 |
| Dietz, J; Hellwich, M; Hellwich, U; Palm, D; Wellstein, A; Wiemer, G | 1 |
| Akita, T; Hartzell, HC; Joyner, RW; Kumar, R; Lu, C | 1 |
| Costa, T; Levi, G; Patrizio, M | 1 |
| Fletcher, JR; Noel, PE; Thompson, WJ | 1 |
| Coughlan, ML; Loi, RK; Warren, JB; Wilson, AJ | 1 |
| Green, RD; Ma, H; Yu, HJ | 1 |
| Barrett, JA; Derian, CK; Rao, PE; Santulli, RJ; Solomon, HF | 1 |
| Barnard, JW; Prasad, VR; Seibert, AF; Smart, DA; Strada, SJ; Taylor, AE; Thompson, WJ | 1 |
| Advenier, C; Karlsson, JA; Naline, E; Qian, Y; Raeburn, D | 1 |
| Beleta, J; Bou, J; Cardelús, I; Cortijo, J; Gristwood, RW; Llenas, J; Morcillo, E | 1 |
| Dickenson, JM; Hill, SJ; White, TE | 1 |
| Karlsson, JA; Raeburn, D; Tomkinson, A | 1 |
| O'Donnell, JM; Ye, Y | 1 |
| Chiu, N; Park, I; Reid, IA | 1 |
| Barnes, PJ; Giembycz, MA; Kelly, JJ | 1 |
| Burns, FM; Kochetkova, M; Souness, JE | 1 |
| Berends, C; de Monchy, JG; Dijkhuizen, B; Dubois, AE; Gerritsen, J; Kauffman, HF | 1 |
| Eckly-Michel, A; Lugnier, C; Martin, V | 1 |
| Baba, J; Sawa, A; Yamashita, N; Yamauchi, M | 1 |
| Götz, KH; Hamann, M; Kurtz, A; Wagner, C | 1 |
| Beleta, J; Collado, MC; Domènech, T; Hernández, J; Martinez, E; Miralpeix, M; Palacios, JM | 1 |
| Braun, U; Kaasik, A; Minajeva, A; Ohisalo, JJ; Paju, K; Seppet, EK; Vetter, R | 1 |
| Adamson, RH; Curry, FE; Fry, GN; Liu, B; Rubin, LL | 1 |
| Juneau, PL; Laemont, KD; Schaefer, CJ; Schrier, DJ | 1 |
| Dormer, RL; Lloyd Mills, C; McPherson, MA; Murray, KJ; Pereira, MM | 1 |
| Parker, JC | 1 |
| Cueff, A; Lacoste, A; Malham, SK; Poulet, SA | 1 |
| Bleiweis, MS; Ciriaco, P; Egan, TM; Hoffmann, SC; Jones, DR; Paik, HC | 1 |
| Abel, D; Danuser, H; Mettler, D; Scholtysik, G; Studer, UE; Walter, B; Weiss, R | 1 |
| Kilpatrick, EL; Lasley, RD; Mentzer, RM; Narayan, P | 1 |
| Ashikaga, T; Kelly, JJ; Liu, L; Strada, SJ; Thompson, WJ; Vemavarapu, L; Zhu, B | 1 |
| Chilcoat, CD; Jones, SL; Rowlingson, KA | 1 |
| Bobalova, J; Mutafova-Yambolieva, VN; Smyth, L | 1 |
| Cui, H; Green, RD | 1 |
| Sadan, G; Tuncel, B; Usta, C | 1 |
| Norton, G; Osadchii, O; Woodiwiss, A | 1 |
| Darby-King, A; Harley, CW; McLean, JH | 1 |
| Baillie, GS; Houslay, MD; Huston, E; Li, X; Lynch, MJ | 1 |
| Bengtsson, T; Evans, BA; Nevzorova, J; Summers, RJ | 1 |
| King, JA; Parker, JC; Randall, J; Stevens, T; Weber, DS | 1 |
| Baillie, GS; Cederberg, A; Enerbäck, S; Grønning, LM; Houslay, MD; Lynch, MJ; Taskén, K | 1 |
| Kaumann, A; Molenaar, P; Semmler, AB | 1 |
| Galindo-Tovar, A; Kaumann, AJ | 1 |
| Adamson, RH; Altangerel, A; Curry, FE; Drenckhahn, D; Lenz, JF; Ly, JC; Sarai, RK | 1 |
| Clark, RB; Rich, TC; Richter, W; Tran, TM; Xin, W | 1 |
| Bruss, MD; Conti, M; Horner, K; Jin, SL; Richter, W | 1 |
| Galindo-Tovar, A; Kaumann, AJ; Vargas, ML | 1 |
| Böhm, M; Lenz, M; Link, A; Maack, C; Selejan, S | 1 |
| Guo, MY; Sairenji, N; Satoh, K | 1 |
| Castro, LR; Cavellini, L; Gervasi, N; Guiot, E; Nikolaev, VO; Paupardin-Tritsch, D; Vincent, P | 1 |
| Gilani, AH; Shah, AJ | 1 |
| Baillie, GS; Bird, RJ; Yarwood, SJ | 1 |
| Adderley, SP; Bowles, EA; Ellsworth, ML; Sprague, RS; Sridharan, M; Stephenson, AH | 1 |
| Afzal, F; Aronsen, JM; Hussain, RI; Krobert, KA; Levy, FO; Osnes, JB; Sjaastad, I; Skomedal, T | 1 |
| Andersen, GØ; Ata, SH; Dahl, CP; Levy, FO; Orstavik, O; Osnes, JB; Qvigstad, E; Riise, J; Skomedal, T | 1 |
| De Arcangelis, V; DiPilato, L; Fu, Q; Kim, S; Liu, S; Shi, Q; Soto, D; Xiang, YK; Xu, B; Zhang, J | 1 |
| Barr, LA; Carter, RL; Cheung, JY; Coleman, RC; Feldman, AM; Gao, E; Grisanti, LA; Houser, SR; Koch, WJ; Li, X; Makarewich, CA; Myers, VD; Song, J; Tilley, DG; Troupes, CD; Yu, D; Zhu, W | 1 |
| Chen, YH; Feng, Z; Geng, L; Li, L; Li, Y; Liang, D; Liu, Y; Ma, H; Wang, C; Wang, G; Wang, S; Xie, D; Xiong, K; Xue, J; Xue, Z; Yang, J; Zhao, T; Zhou, H | 1 |
| Huang, L; Jiang, HL; Lai, KF; Li, XS; Luo, ZH; Shan, WJ; Zhou, Q | 1 |
| Huang, L; Lai, K; Li, X; Liu, A; Luo, Z; Mao, F; Shan, W; Wang, Z; Xie, J | 1 |
| Huang, L; Lai, K; Li, X; Shan, W; Xie, J; Zhou, Q | 1 |
69 other study(ies) available for isoproterenol and rolipram
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Topics: Binding Sites; Cell Line; Computer Simulation; Cyclic Nucleotide Phosphodiesterases, Type 4; Furans; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Protein Isoforms; Pyridazines; Structure-Activity Relationship; Thiadiazines; Triazoles | 2009 |
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines | 1992 |
Studies on the cardiac actions of flosequinan in vitro.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Action Potentials; Animals; Carbachol; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Vasodilator Agents | 1992 |
Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Cell Membrane; Cyclic AMP; Eosinophils; Guinea Pigs; Intracellular Fluid; Isoproterenol; Male; Phosphodiesterase Inhibitors; Protein Kinases; Pyrrolidinones; Rolipram; Superoxides | 1991 |
Effects of phosphodiesterase inhibition on the excitability of hippocampal pyramidal neurons in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Neurons; Phosphodiesterase Inhibitors; Pyramidal Tracts; Pyridazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1991 |
Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Adult; Calcimycin; Chromatography, Ion Exchange; Humans; Isoenzymes; Isoproterenol; Middle Aged; Milrinone; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Rolipram; Superoxides | 1990 |
Evidence for the compartmentation of the enzymes of cyclic AMP metabolism.
Topics: Cell Compartmentation; Colforsin; Cyclic AMP; In Vitro Techniques; Isoproterenol; Organic Chemicals; Phosphodiesterase Inhibitors; Phosphorylase a; Phosphorylases; Pyrrolidinones; Rolipram | 1990 |
Energy-dependent extrusion of cyclic 3',5'-adenosine-monophosphate. A drug-sensitive regulatory mechanism for the intracellular nucleotide concentration in rat erythrocytes.
Topics: Adenosine Triphosphate; Animals; Cyclic AMP; Erythrocytes; In Vitro Techniques; Isoproterenol; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Temperature; Time Factors; Vasodilator Agents | 1982 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Female; Isoproterenol; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rolipram; Ventricular Function | 1994 |
Interferon-gamma and lipopolysaccharide reduce cAMP responses in cultured glial cells: reversal by a type IV phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Astrocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Enzyme Activation; Interferon-gamma; Isoproterenol; Lipopolysaccharides; Microglia; Neuroglia; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Time Factors | 1995 |
Rolipram and isoproterenol reverse platelet activating factor-induced increases in pulmonary microvascular permeability and vascular resistance.
Topics: Animals; Capillary Permeability; Cyclic AMP; In Vitro Techniques; Isoproterenol; Lung; Male; Phosphodiesterase Inhibitors; Platelet Activating Factor; Protein Kinase C; Pyrrolidinones; Rats; Rolipram; Vascular Resistance | 1995 |
Opposing roles of cyclic AMP in the vascular control of edema formation.
Topics: Albuterol; Alprostadil; Animals; Blood Vessels; Bradykinin; Cyclic AMP; Dinoprostone; Drug Synergism; Edema; Endothelium, Vascular; Iloprost; Isoproterenol; Male; Muscle, Smooth, Vascular; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyrrolidinones; Rabbits; Rolipram; Vasoactive Intestinal Peptide | 1993 |
Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Cyclic AMP; Depression, Chemical; Down-Regulation; Drug Synergism; Heart; Isoproterenol; Kinetics; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram | 1993 |
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Benzoxazines; CD18 Antigens; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytoplasmic Granules; Endothelium, Vascular; Humans; Infant, Newborn; Isoproterenol; Macrophage-1 Antigen; Milrinone; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridones; Pyrrolidinones; Respiratory Burst; Rolipram; Umbilical Veins | 1995 |
Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenylyl Cyclases; Animals; Capillary Permeability; Colforsin; Image Processing, Computer-Assisted; Isoproterenol; Lung; Male; Pulmonary Circulation; Pyrrolidinones; Rats; Rats, Inbred Strains; Reperfusion Injury; Rolipram | 1994 |
Effects of rolipram and siguazodan on the human isolated bronchus and their interaction with isoprenaline and sodium nitroprusside.
Topics: Albuterol; Bronchi; Guanidines; Humans; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Nitroprusside; Phosphodiesterase Inhibitors; Pyridazines; Pyrrolidinones; Rolipram | 1993 |
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Middle Aged; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Theophylline; Xanthines | 1993 |
The effects of elevated cyclic AMP levels on histamine-H1-receptor-stimulated inositol phospholipid hydrolysis and calcium mobilization in the smooth-muscle cell line DDT1MF-2.
Topics: Animals; Calcium; Cell Line; Colforsin; Cricetinae; Cyclic AMP; Hydrolysis; Inositol Phosphates; Isoproterenol; Male; Muscle, Smooth; Phosphatidylinositols; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Adrenergic, beta; Receptors, Histamine H1; Rolipram | 1993 |
Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing beta-adrenoceptor subtypes.
Topics: Albuterol; Animals; Bronchi; Cattle; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Methacholine Chloride; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyridazines; Pyrrolidinones; Rolipram; Trachea | 1993 |
Diminished noradrenergic stimulation reduces the activity of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase in rat cerebral cortex.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Hydrolysis; Injections, Intraventricular; Isoproterenol; Male; Norepinephrine; Oxidopamine; Phosphodiesterase Inhibitors; Propranolol; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram | 1996 |
Stimulation of renin secretion by the phosphodiesterase IV inhibitor rolipram.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rabbits; Renin; Rolipram; Time Factors | 1996 |
Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [3H]R-(-)-rolipram binding by selective inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Brain; Chromatography, Ion Exchange; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Isoenzymes; Isoproterenol; Kinetics; Macrophages, Peritoneal; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinazolines; Rats; Regression Analysis; Rolipram; Stereoisomerism; Thiazoles; Tritium | 1996 |
Isoprenaline induction of cAMP-phosphodiesterase in guinea-pig macrophages occurs in the presence, but not in the absence, of the phosphodiesterase type IV inhibitor rolipram.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Animals; Cyclic AMP; Enzyme Induction; Guinea Pigs; Isoproterenol; Macrophages, Peritoneal; Phosphodiesterase Inhibitors; Protein Kinases; Pyrrolidinones; Rolipram | 1995 |
Inhibition of PAF-induced expression of CD11b and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram.
Topics: Bucladesine; CD11 Antigens; Dinoprostone; Eosinophils; Flow Cytometry; Humans; Isoproterenol; L-Selectin; Neutrophils; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pyrrolidinones; Rolipram | 1997 |
Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides | 1997 |
Phosphodiesterase type 4 that regulates cAMP level in cortical neurons shows high sensitivity to rolipram.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Astrocytes; Cerebral Cortex; Cyclic AMP; Guanylate Cyclase; Humans; Isoproterenol; Muscle, Smooth, Vascular; Neurons; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1997 |
Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bumetanide; Cyclic Nucleotide Phosphodiesterases, Type 3; In Vitro Techniques; Isoproterenol; Kidney; Kinetics; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Renin; Rolipram | 1998 |
Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chloride Channels; Cyclic AMP; Diazepam; Drug Interactions; Eosinophils; gamma-Aminobutyric Acid; Guinea Pigs; Heart; In Vitro Techniques; Isoenzymes; Isoproterenol; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Receptors, GABA-A; Rolipram; Tritium | 1998 |
Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to beta-adrenergic agonists in atria.
Topics: Adrenergic beta-Agonists; Animals; Atrial Function; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cyclic AMP; GTP-Binding Proteins; Guanidines; Isoproterenol; Myocardial Contraction; Phenylisopropyladenosine; Phosphorylation; Pyridazines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Rolipram; Thyroid Hormones | 1998 |
Microvascular permeability and number of tight junctions are modulated by cAMP.
Topics: Adrenergic beta-Agonists; Animals; Capillary Permeability; Colforsin; Cyclic AMP; Hemorheology; Isoproterenol; Lymphatic System; Male; Pyrrolidinones; Rana pipiens; Rolipram; Tight Junctions | 1998 |
Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Arthritis, Infectious; Cyclic AMP; Female; Hindlimb; Hormone Antagonists; Isoproterenol; Mifepristone; Neutrophils; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Streptococcal Infections; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1999 |
A cyclic nucleotide PDE5 inhibitor corrects defective mucin secretion in submandibular cells containing antibody directed against the cystic fibrosis transmembrane conductance regulator protein.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Isoproterenol; Mucins; Purinones; Pyridazines; Pyridines; Rats; Rolipram; Submandibular Gland | 1999 |
Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury.
Topics: Animals; Calcium Channel Blockers; Calmodulin; Capillary Permeability; Cyclic AMP; Drug Combinations; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Lung; Lung Diseases; Male; Myosin-Light-Chain Kinase; Organ Size; Phosphodiesterase Inhibitors; Protein Kinase C; Pulmonary Circulation; Rats; Rats, Inbred Strains; Respiration, Artificial; Rolipram; Trifluoperazine | 2000 |
Noradrenaline modulates oyster hemocyte phagocytosis via a beta-adrenergic receptor-cAMP signaling pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flow Cytometry; Hemocytes; Isoproterenol; Isoquinolines; Microscopy, Confocal; Naphthalenes; Norepinephrine; Ostreidae; Phagocytosis; Phenylephrine; Phosphodiesterase Inhibitors; Prazosin; Propranolol; Protein Kinase C; Receptors, Adrenergic, beta; Rolipram; Signal Transduction; Sulfonamides | 2001 |
Maintenance of cAMP in non-heart-beating donor lungs reduces ischemia-reperfusion injury.
Topics: Adenine Nucleotides; Adrenergic beta-Agonists; Animals; Blood Pressure; Cadaver; Capillary Permeability; Cell Survival; Chromatography, High Pressure Liquid; Cyclic AMP; Isoproterenol; Lung; Lung Transplantation; Male; Oxygen; Phosphodiesterase Inhibitors; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; Rolipram; Tissue Donors | 2001 |
Systemic and topical drug administration in the pig ureter: effect of phosphodiesterase inhibitors alpha1, beta and beta2-adrenergic receptor agonists and antagonists on the frequency and amplitude of ureteral contractions.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Female; Fenoterol; Injections, Intravenous; Isoproterenol; Male; Muscle Contraction; Papaverine; Phenylephrine; Phosphodiesterase Inhibitors; Prazosin; Propranolol; Rolipram; Swine; Ureter | 2001 |
Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localization.
Topics: Adenosine; Animals; Cyclic AMP; Heart; Heart Ventricles; Humans; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic Agonists; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Rolipram | 2002 |
Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blotting, Western; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Isoproterenol; Lung; Phosphodiesterase Inhibitors; Rats; Rolipram; Time Factors | 2002 |
The effects of cAMP modulation upon the adhesion and respiratory burst activity of immune complex-stimulated equine neutrophils.
Topics: Adrenergic beta-Agonists; Animals; Antigen-Antibody Complex; Cell Adhesion; Clenbuterol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Horses; Isoproterenol; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors; Respiratory Burst; Rolipram | 2002 |
Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Autonomic Nervous System; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dogs; Edetic Acid; Electric Stimulation; Isoproterenol; Mesenteric Arteries; Mesenteric Veins; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Rolipram; Second Messenger Systems | 2003 |
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Isoproterenol; Milrinone; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Response Elements; Rolipram | 2003 |
The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoenzymes; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Theophylline; Trachea | 2004 |
Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amrinone; Animals; Blood Pressure; Cardiomegaly; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Organ Size; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rolipram | 2005 |
Potentiation and prolongation of long-term odor memory in neonate rats using a phosphodiesterase inhibitor.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Behavior, Animal; Carboxylic Acids; Conditioning, Classical; Cyclohexanecarboxylic Acids; Discrimination Learning; Drug Interactions; Female; Isoproterenol; Male; Memory; Nitriles; Odorants; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Time Factors | 2005 |
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; beta-Adrenergic Receptor Kinases; Cell Line; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; G-Protein-Coupled Receptor Kinase 2; Humans; Isoproterenol; Myocytes, Cardiac; Phosphorylation; Protein Transport; Rolipram | 2006 |
Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Bucladesine; Cell Line; Cholera Toxin; Chromones; Colforsin; Cyclic AMP; Dideoxyadenosine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamines; Glucose; Isoproterenol; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Rats; Receptors, Adrenergic, beta-2; Rolipram; Signal Transduction | 2006 |
Hydraulic conductance of pulmonary microvascular and macrovascular endothelial cell monolayers.
Topics: Adrenergic beta-Agonists; Albumins; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Filtration; Gadolinium; Gap Junctions; Isoproterenol; Lung; Microscopy, Electron; Phosphodiesterase Inhibitors; Pressure; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Rolipram | 2006 |
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Animals; Catecholamines; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Forkhead Transcription Factors; Gene Expression; Isoproterenol; Mice; Mice, Transgenic; Obesity; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta; Rolipram; Signal Transduction | 2006 |
The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Aged; Animals; Atrial Appendage; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Female; Humans; Isometric Contraction; Isoproterenol; Male; Middle Aged; Norepinephrine; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Rolipram; Signal Transduction | 2007 |
Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Female; Heart Atria; Heart Rate; Heart Ventricles; Imidazoles; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Sinoatrial Node; Tachycardia, Sinus; Tachycardia, Ventricular | 2008 |
Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery.
Topics: Adrenergic beta-Agonists; Animals; Cadherins; Capillary Permeability; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indicators and Reagents; Isoproterenol; Male; Microscopy, Confocal; Phosphodiesterase Inhibitors; Platelet Activating Factor; rap1 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Splanchnic Circulation | 2008 |
Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling.
Topics: Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Cell Compartmentation; Cell Line, Transformed; Computer Simulation; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide-Gated Cation Channels; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; G-Protein-Coupled Receptor Kinases; Humans; Intracellular Signaling Peptides and Proteins; Ion Channel Gating; Isoproterenol; Models, Biological; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Receptors, Adrenergic, beta; Rolipram; Signal Transduction | 2008 |
Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.
Topics: Animals; Cell Division; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Embryo, Mammalian; Female; Isoproterenol; Mice; Pregnancy; Rolipram; Signal Transduction | 2008 |
Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Arrhythmia, Sinus; Atrial Function, Left; Atrial Function, Right; Bradycardia; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Partial Agonism; Female; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Stimulation, Chemical; Tachycardia | 2009 |
Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock.
Topics: Adrenergic beta-2 Receptor Agonists; Case-Control Studies; Colforsin; Flow Cytometry; GTP-Binding Proteins; Humans; Isoproterenol; Leukocytes, Mononuclear; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rolipram; Shock, Septic; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Involvement of phosphodiesterase 4 in beta-adrenoceptor agonist-induced amylase release in parotid acinar cells.
Topics: Adrenergic beta-Agonists; Amylases; Animals; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Isoproterenol; Mice; Mice, Inbred Strains; Parotid Gland; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Rolipram | 2009 |
Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons.
Topics: Adenylyl Cyclases; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Cell Membrane; Central Nervous System Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dendrites; In Vitro Techniques; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Parietal Lobe; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Potassium; Pyramidal Cells; Receptors, Adrenergic, beta-1; Rolipram | 2010 |
Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways.
Topics: Acorus; Animals; Atropine; Bronchodilator Agents; Calcium Channel Blockers; Carbachol; Female; Guinea Pigs; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Papaverine; Phosphodiesterase 4 Inhibitors; Plant Extracts; Potassium; Rhizome; Rolipram; Trachea; Verapamil | 2010 |
Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C.
Topics: Binding Sites; Blotting, Western; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; GTP-Binding Proteins; HEK293 Cells; Humans; Hydrolysis; Intracellular Space; Isoproterenol; Kinetics; Mutation; Neoplasm Proteins; Phosphodiesterase 4 Inhibitors; Phosphorylation; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Receptors for Activated C Kinase; Receptors, Cell Surface; Rolipram; Tetradecanoylphorbol Acetate; Transfection | 2010 |
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
Topics: Adenine; Adenosine Triphosphate; Cilostazol; Colforsin; Cyclic AMP; Enzyme Activation; Erythrocytes; Guanine Nucleotide Exchange Factors; Humans; Iloprost; In Vitro Techniques; Isoproterenol; Models, Biological; Naphthalenes; Phosphodiesterase Inhibitors; Protein Kinase C; Rolipram; Signal Transduction; Tetradecanoylphorbol Acetate; Tetrazoles; Thionucleotides | 2011 |
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Carbachol; Cardiotonic Agents; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Failure; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Muscarinic Agonists; Myocardial Contraction; Myocardial Infarction; Pertussis Toxin; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Rats; Rats, Wistar; Rolipram; Ventricular Pressure | 2013 |
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Heart; Heart Failure; Humans; Hydrazones; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Pyridazines; Quinolines; Quinolones; Rats, Wistar; Rolipram; Simendan; Thiadiazines | 2014 |
A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.
Topics: Adaptor Proteins, Signal Transducing; Adrenergic beta-Agonists; Animals; Animals, Newborn; Blotting, Western; Catecholamines; Cell Size; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Discs Large Homolog 1 Protein; Fluorescence Resonance Energy Transfer; Heart; In Vitro Techniques; Isoproterenol; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Fluorescence; Myocardial Contraction; Myocytes, Cardiac; Neurons; Phosphodiesterase 4 Inhibitors; Phosphorylation; Receptors, Adrenergic, beta-1; Rolipram; Signal Transduction | 2014 |
β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Calcium Signaling; Cardiomyopathy, Hypertrophic; Cats; Cell Line, Tumor; Colforsin; Cyclic AMP; G-Protein-Coupled Receptor Kinases; Genes, Reporter; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Failure; HEK293 Cells; Humans; Indoles; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Myocardial Contraction; Pyrrolidines; Receptors, Adrenergic, beta; Receptors, Vasopressin; Recombinant Fusion Proteins; Rolipram; Second Messenger Systems | 2014 |
Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
Topics: Adrenergic beta-Agonists; Animals; Cells, Cultured; Cold Shock Proteins and Peptides; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Rate; Isoproterenol; Male; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; RNA Stability; RNA-Binding Proteins; Rolipram; Sinoatrial Node; Stress, Physiological | 2020 |
Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Drug Design; Guinea Pigs; Inhibitory Concentration 50; Molecular Structure; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Trachea | 2012 |
Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dual β₂-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Aminopyridines; Benzamides; Bronchodilator Agents; Cyclopropanes; Humans; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Salmeterol Xinafoate | 2013 |
Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.
Topics: Adrenergic beta-2 Receptor Agonists; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Design; Ethanolamines; Formoterol Fumarate; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Phthalazines; Receptors, Adrenergic, beta-2; Recombinant Proteins; Structure-Activity Relationship | 2014 |