isopentenyl pyrophosphate has been researched along with zoledronic acid in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baruchello, R; Buccheri, S; Caccamo, N; Dieli, F; Dunford, J; Eleopra, M; Gebbia, N; Invidiata, FP; Kwaasi, A; Limongelli, V; Marchetti, P; Marchioro, C; Marinelli, L; Novellino, E; Provera, S; Rondanin, R; Simoni, D; Tolomeo, M | 1 |
| Auriola, S; Holen, I; Kuokkanen, J; Mönkkönen, H; Mönkkönen, J; Ottewell, PD | 1 |
| Auriola, S; Evans, A; Holen, I; Jauhiainen, M; Kuokkanen, J; Lefley, DV; Mönkkönen, H; Mönkkönen, J | 1 |
| Jauhiainen, M; Mönkkönen, H; Mönkkönen, J; Roelofs, AJ; Rogers, MJ; Thompson, K | 1 |
| Auriola, S; Crockett, JC; Mönkkönen, H; Mönkkönen, J; Räikkönen, J; Rogers, MJ | 1 |
| Mitrofan, LM; Mönkkönen, J; Pelkonen, J | 1 |
| Auriola, S; Mönkkönen, H; Mönkkönen, J; Räikkönen, J | 1 |
| Castells, FB; Mitrofan, LM; Mönkkönen, J; Pelkonen, J | 1 |
| Buccheri, S; Caccamo, N; Cicero, G; D'Asaro, M; Dieli, F; Eberl, M; Guggino, G; Hayday, AC; La Mendola, C; Meraviglia, S; Orlando, V; Roberts, A; Scarpa, F; Stassi, G; Todaro, M; Vermijlen, D | 1 |
| Boudjema, K; Bouet-Toussaint, F; Cabillic, F; Catros, V; Daniel, P; de La Pintière, CT; Lavoué, V; Mönkkönen, H; Mönkkönen, J; Rioux-Leclerc, N; Toutirais, O; Turlin, B | 1 |
| Benzaïd, I; Bonnelye, E; Clézardin, P; Green, J; Mönkkönen, H; Mönkkönen, J; Stresing, V; Touraine, JL | 1 |
| Boccadoro, M; Bosia, A; Canepari, ME; Castella, B; Coscia, M; Fiore, F; Foglietta, M; Massaia, M; Palumbo, A; Pantaleoni, F; Peola, S; Riganti, C | 1 |
| Pauza, CD; Poonia, B | 1 |
| Bank, I; Bendersky, A; Berkun, Y; Gerstein, M; Goldstein, I; Marcu-Malina, V; Nagar, M; Padeh, S | 1 |
| Idrees, AS; Inoue, C; Minato, N; Morita, CT; Murata-Hirai, K; Okamura, H; Sugie, T; Tanaka, Y; Toi, M | 1 |
| Auriola, S; Coimbra de Sousa, S; Ebert, R; Graser, S; Hofbauer, LC; Jakob, F; Määttä, J; Meissner-Weigl, J; Mentrup, B; Rachner, TD; Zeck, S | 1 |
| Chen, HC; Davey, MS; Eberl, M; James, LC; Keeble, AH; Price, AJ; Rhodes, DA; Trowsdale, J | 1 |
| Abe, H; Ashihara, E; Hirai, H; Kanai, M; Kimura, S; Maekawa, T; Miida, T; Munaka, T; Nakagawa, S; Nakagawa, Y; Shoji, S; Yamato, S | 1 |
| Clézardin, P; Gineyts, E; Melodelima, D; Ngo, J; Roux, JP; Tardoski, S | 1 |
| Auriola, S; Gonnermann, D; Janssen, O; Kabelitz, D; Lettau, M; Määttä, J; Nerdal, PT; Oberg, HH; Olive, D; Peters, C; Quabius, ES; Sousa, S; Zlatev, H | 1 |
| Chaudhry, S; Murday, AS; Pauza, CD | 1 |
| Caruso, D; Castella, B; Foglietta, M; Kopecka, J; Mandili, G; Massaia, M; Mitro, N; Novelli, F; Riganti, C; Sciancalepore, P | 1 |
2 trial(s) available for isopentenyl pyrophosphate and zoledronic acid
| Article | Year |
|---|---|
In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.
Topics: Adjuvants, Immunologic; Aged; Breast Neoplasms; Cell Proliferation; Chemokines; Cytokines; Diphosphonates; Disease Progression; Esterases; Female; Hemiterpenes; Humans; Imidazoles; Immunotherapy; Interferon-gamma; Interleukin-2; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Count; Lysine; Middle Aged; Mucin-1; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; Remission Induction; Salvage Therapy; T-Lymphocyte Subsets; TNF-Related Apoptosis-Inducing Ligand; Treatment Outcome; Tumor Necrosis Factor Receptor Superfamily, Member 7; Zoledronic Acid | 2010 |
Cellular interactions of synovial fluid γδ T cells in juvenile idiopathic arthritis.
Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arthritis, Juvenile; Bone Density Conservation Agents; Cell Communication; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Coculture Techniques; Diphosphonates; Female; Fibroblasts; Geranyltranstransferase; Hemiterpenes; Humans; Imidazoles; Interferon-gamma; Lectins, C-Type; Male; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; Synovial Fluid; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha; Zoledronic Acid | 2012 |
20 other study(ies) available for isopentenyl pyrophosphate and zoledronic acid
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.
Topics: Amines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Diphosphonates; Drug Design; Humans; Lymphocyte Activation; Mice; Mice, SCID; Molecular Structure; Receptors, Antigen, T-Cell, gamma-delta; Structure-Activity Relationship | 2008 |
Zoledronic acid-induced IPP/ApppI production in vivo.
Topics: Adenosine Triphosphate; Animals; Bone Density Conservation Agents; Bone Marrow Cells; Bone Resorption; Cells, Cultured; Diphosphonates; Geranyltranstransferase; Hemiterpenes; Imidazoles; Macrophages, Peritoneal; Mevalonic Acid; Mice; Organophosphorus Compounds; Time Factors; Zoledronic Acid | 2007 |
Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Apoptosis; Blotting, Western; Bone Density Conservation Agents; Cell Line, Tumor; Cell Proliferation; Clodronic Acid; Diphosphonates; Geranyltranstransferase; Hemiterpenes; Humans; Imidazoles; Organophosphorus Compounds; Protein Prenylation; rap1 GTP-Binding Proteins; Zoledronic Acid | 2008 |
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.
Topics: Cell Communication; Cells, Cultured; Diphosphonates; Hemiterpenes; Humans; Imidazoles; Lymphocyte Activation; Monocytes; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Zoledronic Acid | 2009 |
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Bone Density Conservation Agents; Cell Line, Tumor; Clodronic Acid; Diphosphonates; Hemiterpenes; Humans; Imidazoles; In Vitro Techniques; Organophosphorus Compounds; Osteoclasts; Rabbits; Zoledronic Acid | 2009 |
The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro.
Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Diphosphonates; Diterpenes; Drug Resistance, Neoplasm; Hemiterpenes; Humans; Imidazoles; Lovastatin; Membrane Potential, Mitochondrial; Neoplasms; Organophosphorus Compounds; Zoledronic Acid | 2009 |
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells.
Topics: Adenosine Triphosphate; Anticarcinogenic Agents; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Down-Regulation; Drug Screening Assays, Antitumor; Farnesol; Female; Gene Expression Regulation, Neoplastic; Hemiterpenes; Humans; Imidazoles; Mevalonic Acid; Organophosphorus Compounds; Zoledronic Acid | 2010 |
Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells.
Topics: Adenosine Triphosphate; Animals; Apoptosis; bcl-X Protein; Caspase Inhibitors; Cathepsins; Cattle; Cell Line, Tumor; Cell Membrane Permeability; Diphosphonates; Hemiterpenes; Humans; Imidazoles; Lymphoma, Follicular; Lysosomes; Mevalonic Acid; Mice; Mitochondria; Organophosphorus Compounds; Prenylation; Protease Inhibitors; Signal Transduction; Zoledronic Acid | 2010 |
Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients.
Topics: Adenocarcinoma; Aged; Blotting, Western; Bone Density Conservation Agents; Carcinoma, Hepatocellular; Cell Differentiation; Cell Proliferation; Coculture Techniques; Colorectal Neoplasms; Cytotoxicity, Immunologic; Dendritic Cells; Diphosphates; Diphosphonates; Female; Flow Cytometry; Hemiterpenes; Humans; Imidazoles; Immunotherapy, Adoptive; Liver Neoplasms; Male; Middle Aged; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; Zoledronic Acid | 2010 |
High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.
Topics: Adenosine Triphosphate; Animals; Antigens, Neoplasm; Breast Neoplasms; Cell Line, Tumor; Cytotoxicity, Immunologic; Diphosphonates; Female; Hemiterpenes; Humans; Imidazoles; Mice; Mice, Inbred NOD; Mice, SCID; Organophosphorus Compounds; Phosphorylation; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Zoledronic Acid | 2011 |
Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells.
Topics: B7-1 Antigen; Bone Density Conservation Agents; CD8-Positive T-Lymphocytes; Cell Communication; Cell Proliferation; Dendritic Cells; Diphosphonates; Gene Expression Regulation; Hemiterpenes; Humans; Imidazoles; Lymphocyte Activation; Mevalonic Acid; Monocytes; Multiple Myeloma; Organophosphorus Compounds; Programmed Cell Death 1 Ligand 2 Protein; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Zoledronic Acid | 2011 |
Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity.
Topics: Anti-Retroviral Agents; Antibody-Dependent Cell Cytotoxicity; CD56 Antigen; Cell Line, Tumor; Diphosphonates; GPI-Linked Proteins; Hemiterpenes; HIV; HIV Infections; Humans; Imidazoles; Immunophenotyping; Interleukin-2; Lymphocyte Activation; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; Receptors, IgG; T-Lymphocytes; Zoledronic Acid | 2012 |
Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid.
Topics: Cell Line, Tumor; Cytotoxicity, Immunologic; Diphosphonates; Geranyltranstransferase; Hemiterpenes; HL-60 Cells; Humans; Imidazoles; K562 Cells; Leukemia, Myeloid; Lymphoma; MCF-7 Cells; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Tumor Necrosis Factor-alpha; U937 Cells; Zoledronic Acid | 2013 |
Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Breast Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Connexins; Diphosphonates; Etidronic Acid; Female; Hemiterpenes; Humans; Ibandronic Acid; Imidazoles; MCF-7 Cells; Multidrug Resistance-Associated Proteins; Nerve Tissue Proteins; Organophosphorus Compounds; Osteoclasts; Phosphate Transport Proteins; Probenecid; Risedronic Acid; Zoledronic Acid | 2014 |
Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.
Topics: Animals; Antigens; Antigens, CD; Binding Sites; Butyrophilins; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Crystallography, X-Ray; Diphosphates; Diphosphonates; Escherichia coli; Gene Expression Regulation; Hemiterpenes; Humans; Imidazoles; Lymphocyte Activation; Membrane Proteins; Models, Molecular; Organophosphorus Compounds; Phosphoproteins; Plakins; Primary Cell Culture; Protein Binding; Receptors, Antigen, T-Cell, gamma-delta; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes; Two-Hybrid System Techniques; Zoledronic Acid | 2015 |
Isopentenyl pyrophosphate secreted from Zoledronate-stimulated myeloma cells, activates the chemotaxis of γδT cells.
Topics: Cell Line, Tumor; Chemotaxis, Leukocyte; Culture Media, Conditioned; Diphosphonates; Hemiterpenes; Humans; Imidazoles; Multiple Myeloma; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Zoledronic Acid | 2015 |
Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer.
Topics: Animals; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Diphosphonates; Disease Models, Animal; Female; Hemiterpenes; Humans; Hyperthermia, Induced; Imidazoles; Organophosphorus Compounds; rap1 GTP-Binding Proteins; Ultrasonic Waves; Xenograft Model Antitumor Assays; Zoledronic Acid | 2015 |
Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations.
Topics: Antibodies, Blocking; Antigens, CD; Butyrophilins; CD4-Positive T-Lymphocytes; Cells, Cultured; Diphosphonates; Geranyltranstransferase; Hemiterpenes; Humans; Imidazoles; Interleukin-18; Lymphocyte Activation; Mevalonic Acid; Monocytes; Neutrophils; Organophosphates; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Zoledronic Acid | 2016 |
Interleukin-18 activates Vγ9Vδ2
Topics: Antigens; Cell Proliferation; Cells, Cultured; Diphosphonates; Hemiterpenes; HIV Infections; HIV-1; Humans; Imidazoles; Immunologic Memory; Immunophenotyping; Immunotherapy; Interleukin-18; Killer Cells, Natural; Lymphocyte Activation; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Zoledronic Acid | 2017 |
The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Antigens, CD; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; Butyrophilins; Cell Proliferation; Dendritic Cells; Hemiterpenes; Humans; Immunophenotyping; Lipid Metabolism; Lymphocyte Activation; Organophosphorus Compounds; Phosphatidylinositol 3-Kinases; Protein Binding; Receptors, Antigen, T-Cell, gamma-delta; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; T-Lymphocytes; U937 Cells; Zoledronic Acid | 2017 |