isopentenyl pyrophosphate and farnesyl pyrophosphate

isopentenyl pyrophosphate has been researched along with farnesyl pyrophosphate in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-199013 (21.67)18.7374
1990's14 (23.33)18.2507
2000's18 (30.00)29.6817
2010's14 (23.33)24.3611
2020's1 (1.67)2.80

Authors

AuthorsStudies
Chambliss, KL; Gibson, KM; Hinson, DD; Tanaka, RD; Toth, MJ1
Tait, RM1
Lutz, RJ; McLain, TM; Sinensky, M1
Chojnacki, T; Dallner, G; Ericsson, J; Runquist, M; Thelin, A1
Chojnacki, T; Dallner, G; Ericsson, J; Thelin, A1
Kim, SH; Mayer, MP; Poulter, CD; Rine, J; Rosenberg, S; Schafer, WR; Trueblood, CE; Yang, CC1
Edorh, GG; Karst, F; Mbaya, B; Rigomier, D; Schrevel, J1
Koyama, T; Ogura, K; Yoshida, I2
Fujisaki, S; Hara, H; Hirota, Y; Katsuki, H; Nishimura, Y; Nishino, T1
Croteau, R; Purkett, PT1
Dennis, MS; Light, DR1
Dennis, MS; Lazarus, RA; Light, DR1
Lennarz, WJ; Ogura, K; Sagami, H1
Davisson, VJ; Poulter, CD; Woodside, AB1
Bruenger, E; Rilling, HC1
Fujisaki, S; Katsuki, H; Nishino, T1
Bhavnani, BR1
Ishii, K; Ogura, K; Sagami, H1
Ogura, K; Takahashi, I1
Delourme, D; Karst, F; Lacroute, F1
Christensen, DJ; Poulter, CD1
Korenaga, T; Kurisaki, A; Ogura, K; Sagami, H1
Korenaga, T; Ogura, K; Sagami, H1
Keller, RK1
Hirai, A; Kitagawa, M; Noguchi, Y; Saito, Y; Shiina, T; Tanaka, T; Tatsuno, I; Terano, T; Yasuda, T1
Fliesler, SJ; Keller, RK1
Han, KH; Kang, H; Kang, MY1
Chiou, ST; Liang, PH; Pan, JJ1
Fushie, T; Itoh, D; Karunagoda, RP; Katoh, K; Nabeta, K1
Koyama, T; Li, XY; Zhang, YW1
Lee, HK; Li, H; Mariuzza, RA; Morita, CT; Tanaka, Y; Wang, H1
Phan, RM; Poulter, CD1
Chen, YK; Kuo, TH; Liang, PH; Pan, JJ; Yang, LW1
Berry, A; Hümbelin, M; Jore, J; Li, J; Lin, J; Thomas, A1
Chang, SY; Chen, AP; Ko, TP; Liang, PH; Wang, AH1
Baulard, AR; Brennan, PJ; Crick, DC; Dhiman, RK; Mahapatra, S; Schulbach, MC; Vissa, V1
Chang, SY; Chen, AP; Chen, CT; Liang, PH; Lin, YC; Sun, YS; Wang, AH1
Chen, AP; Guo, RT; Ko, TP; Kuo, CJ; Liang, PH; Wang, AH1
Dordick, JS; Jeong, JC; Ku, B; Mijts, BN; Schmidt-Dannert, C1
Noghabi, KA; Shin, YC; Zahiri, HS1
Beyer, P; Kloer, DP; Schulz, GE; Welsch, R1
Fujisaki, S; Nishino, T; Saito, K1
Liang, PH; Liu, HG; Lu, YP1
de Diego, A; Pérez-Zúñiga, FJ; Sillero, A; Sillero, MA; Silva, JA; Tavares, JE1
Hyegin, L; Koyama, T; Noike, M; Rojruthai, P; Sakdapipanich, JT; Takahashi, S; Tanaka, Y1
Choi, ES; Chung, YR; Keasling, JD; Kim, JY; Kim, SW; Shah, AA; Wang, C; Yoon, SH1
Liang, PH; Liu, HG; Lu, YP; Teng, KH1
Liang, PH; Teng, KH2
Clastre, M; Courdavault, V; Giglioli-Guivarc'h, N; Papon, N; Simkin, AJ; St-Pierre, B1
Guo, G; Guo, Y; Li, D; Mao, X; Wang, DC; Wu, C; Zhang, J; Zhang, R; Zhang, X; Zhang, Y; Zou, Q1
Cornish, K; Xie, W1
Chen, X; Stephanopoulos, G; Too, HP; Zhang, C; Zhou, K; Zou, R1
Dudareva, N; Gutensohn, M; Henry, LK; Noel, JP; Thomas, ST1
Fujiyama, K; Kajiura, H; Kaneko, Y; Matsumura, H; Nakazawa, Y; Suzuki, N; Takeno, S; Tokumoto, Y; Yoshizawa, T1
Jiang, L; Li, W; Luo, Y; Yang, L; Yang, Y; Zhang, G1
Agosin, E; Almonacid, D; González-Nilo, F; Rubat, S; Sepúlveda, R; Varas, I1
Ding, MZ; Liu, D; Liu, H; Song, TQ; Xiao, WH; Yuan, YJ; Zhai, F1
Amzel, LM; Aripirala, S; Gabelli, SB; Kim, YS; Maheshwari, S; Murphy, M1

Reviews

2 review(s) available for isopentenyl pyrophosphate and farnesyl pyrophosphate

ArticleYear
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis.
    Bioorganic chemistry, 2012, Volume: 43

    Topics: Alkyl and Aryl Transferases; Bacteria; Hemiterpenes; Organophosphorus Compounds; Peptidoglycan; Polyisoprenyl Phosphates; Protein Structure, Tertiary; Sesquiterpenes; Terpenes; Transferases

2012
Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis.
    Molecular membrane biology, 2012, Volume: 29, Issue:7

    Topics: Alkyl and Aryl Transferases; Bacteria; Bacterial Proteins; Cell Wall; Dimethylallyltranstransferase; Hemiterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Structure, Tertiary; Sesquiterpenes; Structure-Activity Relationship

2012

Other Studies

58 other study(ies) available for isopentenyl pyrophosphate and farnesyl pyrophosphate

ArticleYear
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
    Journal of lipid research, 1997, Volume: 38, Issue:11

    Topics: Carboxy-Lyases; Cholesterol; Dolichol Phosphates; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Gene Expression; Humans; Kinetics; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Phosphotransferases (Phosphate Group Acceptor); Polyisoprenyl Phosphates; Recombinant Proteins; Sesquiterpenes; Terpenes

1997
Development of a radiometric spot-wash assay for squalene synthase.
    Analytical biochemistry, 1992, Volume: 203, Issue:2

    Topics: Animals; Chromatography, Thin Layer; Farnesyl-Diphosphate Farnesyltransferase; Female; Hemiterpenes; Liver; NADP; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Squalene

1992
Feedback inhibition of polyisoprenyl pyrophosphate synthesis from mevalonate in vitro. Implications for protein prenylation.
    The Journal of biological chemistry, 1992, Apr-25, Volume: 267, Issue:12

    Topics: Animals; Carbon-Carbon Double Bond Isomerases; Cell-Free System; Chromatography, High Pressure Liquid; Feedback; Hemiterpenes; Isomerases; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Proteins; Rabbits; Sesquiterpenes

1992
Biosynthesis of trans,trans,trans-geranylgeranyl diphosphate by the cytosolic fraction from rat tissues.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    Topics: Animals; Brain; Cations, Divalent; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytosol; Hemiterpenes; Isomerism; Kidney; Kinetics; Liver; Male; Organ Specificity; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Sesquiterpenes; Spleen; Testis; Tritium

1992
Characterization and distribution of cis-prenyl transferase participating in liver microsomal polyisoprenoid biosynthesis.
    European journal of biochemistry, 1991, Dec-18, Volume: 202, Issue:3

    Topics: Animals; Cations, Divalent; Detergents; Dimethylallyltranstransferase; Dolichols; Hemiterpenes; Intracellular Membranes; Kinetics; Male; Microsomes, Liver; Octoxynol; Organophosphorus Compounds; Polyethylene Glycols; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Sesquiterpenes

1991
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein.
    Science (New York, N.Y.), 1990, Sep-07, Volume: 249, Issue:4973

    Topics: Amino Acid Sequence; Cell Compartmentation; Cholesterol; Dimethylallyltranstransferase; DNA Mutational Analysis; Fungal Proteins; Genes, Fungal; Hemiterpenes; Humans; In Vitro Techniques; Mating Factor; Molecular Sequence Data; Oncogene Protein p21(ras); Organophosphorus Compounds; Peptides; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Restriction Mapping; Saccharomyces cerevisiae; Sesquiterpenes; Transferases

1990
Isoprenoid metabolism in Plasmodium falciparum during the intraerythrocytic phase of malaria.
    Biochemical and biophysical research communications, 1990, Dec-31, Volume: 173, Issue:3

    Topics: Acetates; Animals; Cells, Cultured; Erythrocytes; Hemiterpenes; Humans; Malaria; Mevalonic Acid; Organophosphorus Compounds; Plasmodium falciparum; Polyisoprenyl Phosphates; Saccharomyces cerevisiae; Sesquiterpenes

1990
Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents.
    Biochimica et biophysica acta, 1989, Apr-06, Volume: 995, Issue:2

    Topics: Aldehydes; Alkyl and Aryl Transferases; Arginine; Butanones; Chloromercuribenzoates; Cyclohexanes; Cyclohexanones; Diacetyl; Dimethylallyltranstransferase; Diphosphates; Enzyme Activation; Ethylmaleimide; Hemiterpenes; Iodoacetamide; Magnesium; Micrococcus; Organophosphorus Compounds; p-Chloromercuribenzoic Acid; Phenylglyoxal; Polyisoprenyl Phosphates; Sesquiterpenes; Sulfhydryl Reagents; Transferases

1989
Formation of a stable and catalytically active complex of the two essential components of hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26.
    Biochemical and biophysical research communications, 1989, Apr-28, Volume: 160, Issue:2

    Topics: Alkyl and Aryl Transferases; Catalysis; Chromatography, Gel; Dimethylallyltranstransferase; Diphosphates; Enzyme Stability; Hemiterpenes; Macromolecular Substances; Micrococcus; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Substrate Specificity; Transferases

1989
Isolation and characterization of an Escherichia coli mutant having temperature-sensitive farnesyl diphosphate synthase.
    Journal of bacteriology, 1989, Volume: 171, Issue:10

    Topics: Alkyl and Aryl Transferases; Chromatography, High Pressure Liquid; Chromosome Mapping; Escherichia coli; Geranyltranstransferase; Hemiterpenes; Mutation; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Temperature; Transferases; Ubiquinone

1989
Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis).
    Archives of biochemistry and biophysics, 1989, Volume: 271, Issue:2

    Topics: Cell-Free System; Chromatography; Chromatography, Thin Layer; Dimethylallyltranstransferase; Hemiterpenes; Hydrogen-Ion Concentration; Organophosphorus Compounds; Plants; Polyisoprenyl Phosphates; Sesquiterpenes; Terpenes; Transferases

1989
Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Amino Acid Sequence; Chromatography; Chromatography, High Pressure Liquid; Dimethylallyltranstransferase; Dithiothreitol; Hemiterpenes; Kinetics; Latex; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Organophosphorus Compounds; Plants; Polyisoprenyl Phosphates; Rubber; Sesquiterpenes; Substrate Specificity; Transferases; Trees

1989
Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Animals; Chickens; Dimethylallyltranstransferase; Hemiterpenes; Liver; Molecular Weight; Organophosphorus Compounds; Phosphates; Plants; Polyisoprenyl Phosphates; Rubber; Sesquiterpenes; Stereoisomerism; Substrate Specificity; Transferases; Trees

1989
The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes.
    Biochimica et biophysica acta, 1989, Apr-03, Volume: 1002, Issue:2

    Topics: Animals; Dolichol Phosphates; Hemiterpenes; Kinetics; Magnesium; Magnesium Chloride; Male; Microsomes, Liver; Octoxynol; Organophosphorus Compounds; Polyethylene Glycols; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Sesquiterpenes

1989
Synthesis of allylic and homoallylic isoprenoid pyrophosphates.
    Methods in enzymology, 1985, Volume: 110

    Topics: Diphosphates; Hemiterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes

1985
Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis.
    Analytical biochemistry, 1988, Volume: 173, Issue:2

    Topics: Animals; Cholesterol; Hemiterpenes; Liver; Mice; Mice, Inbred Strains; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Scintillation Counting; Sesquiterpenes

1988
Biosynthesis of isoprenoids in intact cells of Escherichia coli.
    Journal of biochemistry, 1986, Volume: 99, Issue:4

    Topics: Carbon Radioisotopes; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, Thin Layer; Escherichia coli; Freeze Drying; Hemiterpenes; Isomerism; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes

1986
Oestrogen biosynthesis in the pregnant mare.
    The Journal of endocrinology, 1981, Volume: 89 Suppl

    Topics: Acetates; Alkenes; Androstenedione; Animals; Chemical Phenomena; Chemistry; Cholesterol; Dehydroepiandrosterone; Equilin; Estrogens; Farnesol; Female; Hemiterpenes; Horses; Maternal-Fetal Exchange; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Pregnancy; Pregnancy, Animal; Sesquiterpenes; Squalene; Tyrosine

1981
Decaprenyl pyrophosphate synthetase from mitochondria of pig liver.
    Biochemical and biophysical research communications, 1983, Oct-31, Volume: 116, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Hemiterpenes; Mitochondria, Liver; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Swine; Transferases

1983
Farnesyl pyrophosphate synthetase from Bacillus subtilis.
    Journal of biochemistry, 1981, Volume: 89, Issue:5

    Topics: Alkenes; Bacillus subtilis; Bacitracin; Detergents; Dimethylallyltranstransferase; Farnesol; Hemiterpenes; Magnesium; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Sulfhydryl Reagents; Transferases

1981
Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast.
    Plant molecular biology, 1994, Volume: 26, Issue:6

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Arabidopsis; Base Sequence; Cloning, Molecular; DNA, Complementary; Ergosterol; Genetic Complementation Test; Geranyltranstransferase; Hemiterpenes; Molecular Sequence Data; Organophosphorus Compounds; Plant Proteins; Polyisoprenyl Phosphates; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sesquiterpenes; Transferases

1994
Enzymatic synthesis of isotopically labeled isoprenoid diphosphates.
    Bioorganic & medicinal chemistry, 1994, Volume: 2, Issue:7

    Topics: Alkyl and Aryl Transferases; Animals; Birds; Carbon Isotopes; Carbon-Carbon Double Bond Isomerases; Escherichia coli; Farnesyltranstransferase; Hemiterpenes; Indicators and Reagents; Isomerases; Isotope Labeling; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Polyisoprenyl Phosphates; Recombinant Proteins; Saccharomyces cerevisiae; Sesquiterpenes; Transferases

1994
Biosynthesis of prenyl diphosphates by cell-free extracts from mammalian tissues.
    Journal of biochemistry, 1993, Volume: 114, Issue:1

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Dimethylallyltranstransferase; Hemiterpenes; Liver; Male; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Sesquiterpenes

1993
Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.
    Journal of biochemistry, 1993, Volume: 114, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Brain; Cattle; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Farnesyltranstransferase; Hemiterpenes; Isoelectric Focusing; Kinetics; Magnesium; Manganese; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Substrate Specificity; Transferases

1993
Squalene synthase inhibition alters metabolism of nonsterols in rat liver.
    Biochimica et biophysica acta, 1996, Oct-18, Volume: 1303, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hemiterpenes; Liver; Male; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tricarboxylic Acids

1996
Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells.
    Journal of atherosclerosis and thrombosis, 1998, Volume: 5, Issue:1

    Topics: Animals; Biological Transport; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; GTP-Binding Proteins; Hemiterpenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Liposomes; Membrane Proteins; Muscle, Smooth, Vascular; Organophosphorus Compounds; Polyisoprenyl Phosphates; Pravastatin; Rats; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; S Phase; Sesquiterpenes

1998
Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway.
    Biochemical and biophysical research communications, 1999, Dec-20, Volume: 266, Issue:2

    Topics: Alendronate; Alkyl and Aryl Transferases; Animals; Chromatography, High Pressure Liquid; Cytosol; Geranyltranstransferase; Hemiterpenes; Kinetics; Liver; Male; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Sesquiterpenes

1999
Identification of natural rubber and characterization of rubber biosynthetic activity in fig tree.
    Plant physiology, 2000, Volume: 123, Issue:3

    Topics: Cations, Divalent; Chromatography, Gel; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Euphorbiaceae; Hemiterpenes; Latex; Magnesium; Magnetic Resonance Spectroscopy; Molecular Weight; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rosales; Rubber; Sesquiterpenes; Spectroscopy, Fourier Transform Infrared

2000
Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction.
    Biochemistry, 2000, Sep-05, Volume: 39, Issue:35

    Topics: Alkyl and Aryl Transferases; Buffers; Computer Simulation; Escherichia coli; Hemiterpenes; Kinetics; Octoxynol; Organophosphorus Compounds; Polyisoprenyl Phosphates; Recombinant Fusion Proteins; Sesquiterpenes; Software; Substrate Specificity

2000
Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus.
    Journal of natural products, 2000, Volume: 63, Issue:8

    Topics: Antioxidants; Chlorophyll; Chlorophyll A; Chromatography, Agarose; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cinnamates; Depsides; Hemiterpenes; Isotope Labeling; Magnetic Resonance Spectroscopy; Mevalonic Acid; Optical Rotation; Organophosphorus Compounds; Plants; Polyisoprenyl Phosphates; Rosmarinic Acid; Sesquiterpenes

2000
Chain length determination of prenyltransferases: both heteromeric subunits of medium-chain (E)-prenyl diphosphate synthase are involved in the product chain length determination.
    Biochemistry, 2000, Oct-17, Volume: 39, Issue:41

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Bacillus subtilis; Catalysis; Dimerization; Dimethylallyltranstransferase; Hemiterpenes; Kinetics; Micrococcus luteus; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphorus Compounds; Peptide Fragments; Polyisoprenyl Phosphates; Recombinant Proteins; Sesquiterpenes

2000
Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human gamma delta T cells.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Jul-01, Volume: 167, Issue:1

    Topics: Adult; Antigens; Binding Sites; Cell Line; Clone Cells; Diphosphates; Epitopes, T-Lymphocyte; Hemiterpenes; Humans; Jurkat Cells; Organophosphorus Compounds; Polyisoprenyl Phosphates; Receptors, Antigen, T-Cell, gamma-delta; Sesquiterpenes; T-Lymphocyte Subsets; Transfection

2001
Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors.
    The Journal of organic chemistry, 2001, Oct-05, Volume: 66, Issue:20

    Topics: Animals; Birds; Carbon Radioisotopes; Enzyme Inhibitors; Hemiterpenes; Kinetics; Organophosphorus Compounds; Polyisoprenyl Phosphates; Pyrophosphatases; Sesquiterpenes

2001
Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis.
    Biochimica et biophysica acta, 2002, Jan-31, Volume: 1594, Issue:1

    Topics: Alkyl and Aryl Transferases; Enzyme Activation; Escherichia coli; Hemiterpenes; Hydrogen-Ion Concentration; Kinetics; Organophosphorus Compounds; Polyethylene Glycols; Polyisoprenyl Phosphates; Sesquiterpenes; Temperature

2002
Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens.
    Gene, 2002, Sep-04, Volume: 297, Issue:1-2

    Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Amino Acid Sequence; Bacterial Proteins; Carbon-Carbon Double Bond Isomerases; DNA, Bacterial; Hemiterpenes; Hydroxymethylglutaryl CoA Reductases; Membrane Proteins; Mevalonic Acid; Molecular Sequence Data; Organophosphorus Compounds; Paracoccus; Polyisoprenyl Phosphates; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sesquiterpenes; Terpenes

2002
Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies.
    Protein science : a publication of the Protein Society, 2004, Volume: 13, Issue:4

    Topics: Alkyl and Aryl Transferases; Binding Sites; Catalysis; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Magnesium; Models, Chemical; Octoxynol; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Binding; Protein Structure, Tertiary; Sesquiterpenes; Sulfates

2004
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
    Journal of lipid research, 2004, Volume: 45, Issue:6

    Topics: Alkyl and Aryl Transferases; Butanols; Chromatography, Thin Layer; Geranyltranstransferase; Hemiterpenes; Kinetics; Molecular Structure; Mycobacterium tuberculosis; Organophosphorus Compounds; Phylogeny; Polyisoprenyl Phosphates; Recombinant Proteins; Sesquiterpenes; Stereoisomerism; Substrate Specificity

2004
Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.
    The Biochemical journal, 2005, Feb-15, Volume: 386, Issue:Pt 1

    Topics: Alkyl and Aryl Transferases; Binding Sites; Escherichia coli Proteins; Farnesol; Hemiterpenes; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Molecular Weight; Mutagenesis, Site-Directed; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Conformation; Recombinant Fusion Proteins; Sesquiterpenes; Substrate Specificity

2005
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis.
    The Journal of biological chemistry, 2005, May-27, Volume: 280, Issue:21

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Cell Wall; Conserved Sequence; Crystallization; Crystallography, X-Ray; Escherichia coli; Hemiterpenes; Hydrogen Bonding; Kinetics; Magnesium; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphorus Compounds; Peptidoglycan; Polyisoprenyl Phosphates; Protein Folding; Sequence Alignment; Sesquiterpenes; Structure-Activity Relationship

2005
Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway.
    Applied and environmental microbiology, 2005, Volume: 71, Issue:11

    Topics: Bacterial Proteins; Biotechnology; Carotenoids; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Farnesyl-Diphosphate Farnesyltransferase; Geranyltranstransferase; Hemiterpenes; Kinetics; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes

2005
Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production.
    Applied microbiology and biotechnology, 2006, Volume: 73, Issue:4

    Topics: Agrobacterium tumefaciens; Alkyl and Aryl Transferases; Chromatography, Thin Layer; Cloning, Molecular; Coenzymes; Diphosphates; Diterpenes; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hemiterpenes; Kinetics; Molecular Sequence Data; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rhodobacter sphaeroides; Sequence Analysis, DNA; Sesquiterpenes; Substrate Specificity; Ubiquinone

2006
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba.
    Biochemistry, 2006, Dec-26, Volume: 45, Issue:51

    Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Diterpenes; Escherichia coli; Farnesyltranstransferase; Hemiterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Sinapis; Substrate Specificity

2006
Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase.
    Journal of bioscience and bioengineering, 2007, Volume: 103, Issue:6

    Topics: Alkyl and Aryl Transferases; Diterpenes; Escherichia coli; Gene Deletion; Genes, Bacterial; Geranyltranstransferase; Hemiterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Terpenes

2007
Different reaction mechanisms for cis- and trans-prenyltransferases.
    Biochemical and biophysical research communications, 2009, Feb-06, Volume: 379, Issue:2

    Topics: Alkyl and Aryl Transferases; Chromatography, Thin Layer; Diphosphates; Hemiterpenes; Organophosphates; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Substrate Specificity; Transferases

2009
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases
    Biochemical pharmacology, 2009, Aug-15, Volume: 78, Issue:4

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Chromatography, High Pressure Liquid; Diphosphates; Diphosphonates; Diterpenes; DNA Ligases; Hemiterpenes; Mevalonic Acid; Organophosphorus Compounds; Osteoclasts; Polyisoprenyl Phosphates; Polyphosphates; RNA Ligase (ATP); Sesquiterpenes; Substrate Specificity

2009
In vitro synthesis of high molecular weight rubber by Hevea small rubber particles.
    Journal of bioscience and bioengineering, 2010, Volume: 109, Issue:2

    Topics: Hemiterpenes; Hevea; Molecular Weight; Organophosphorus Compounds; Plant Proteins; Polyisoprenyl Phosphates; Rubber; Sesquiterpenes

2010
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway.
    Biotechnology and bioengineering, 2010, Oct-15, Volume: 107, Issue:3

    Topics: Culture Media; Escherichia coli; Farnesol; Gene Dosage; Gene Expression; Geranyltranstransferase; Hemiterpenes; Metabolic Networks and Pathways; Mevalonic Acid; Organophosphorus Compounds; Plasmids; Polyisoprenyl Phosphates; Sesquiterpenes

2010
Mechanism of cis-prenyltransferase reaction probed by substrate analogues.
    Biochemical and biophysical research communications, 2010, Oct-01, Volume: 400, Issue:4

    Topics: Alkyl and Aryl Transferases; Catalysis; Escherichia coli; Hemiterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Substrate Specificity; Transferases

2010
Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis.
    Plant signaling & behavior, 2011, Volume: 6, Issue:12

    Topics: Arabidopsis; Carbon-Carbon Double Bond Isomerases; Carboxy-Lyases; Catharanthus; Hemiterpenes; Organophosphorus Compounds; Peroxisomes; Phosphotransferases (Phosphate Group Acceptor); Plant Proteins; Polyisoprenyl Phosphates; Sesquiterpenes; Terpenes

2011
Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases.
    The international journal of biochemistry & cell biology, 2012, Volume: 44, Issue:12

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Helicobacter pylori; Hemiterpenes; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Molecular Docking Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Sesquiterpenes

2012
Natural rubber biosynthesis in plants: rubber transferase.
    Methods in enzymology, 2012, Volume: 515

    Topics: Animals; Asteraceae; Enzyme Activation; Enzyme Assays; Enzyme Stability; Hemiterpenes; Hevea; Immunoprecipitation; Kinetics; Latex; Molecular Weight; Organophosphorus Compounds; Photoaffinity Labels; Plant Bark; Plant Proteins; Polyisoprenyl Phosphates; Rubber; Sesquiterpenes; Transferases

2012
Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Alkyl and Aryl Transferases; Geranyltranstransferase; Hemiterpenes; Mevalonic Acid; Organophosphorus Compounds; Polycyclic Sesquiterpenes; Polyisoprenyl Phosphates; Research Design; Sesquiterpenes

2013
Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-11, Volume: 112, Issue:32

    Topics: Arabidopsis; Arabidopsis Proteins; Archaea; Cytosol; Gene Expression Regulation, Plant; Gene Knockout Techniques; Genes, Plant; Hemiterpenes; Kinetics; Metabolic Networks and Pathways; Mevalonic Acid; Nicotiana; Organophosphorus Compounds; Phosphotransferases (Alcohol Group Acceptor); Plants, Genetically Modified; Plastids; Polyisoprenyl Phosphates; Sequence Homology, Amino Acid; Sesquiterpenes; Terpenes

2015
Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences.
    Biochimie, 2017, Volume: 139

    Topics: Amino Acid Sequence; Eucommiaceae; Geranyltranstransferase; Hemiterpenes; Kinetics; Models, Molecular; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sequence Homology, Amino Acid; Sesquiterpenes; Substrate Specificity

2017
A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli.
    Journal of industrial microbiology & biotechnology, 2017, Volume: 44, Issue:10

    Topics: Acyclic Monoterpenes; Camptotheca; Diphosphates; Diterpenes; DNA, Complementary; Escherichia coli; Geranyltranstransferase; Hemiterpenes; Monoterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Polymerase Chain Reaction; Sesquiterpenes; Terpenes

2017
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase.
    FEMS yeast research, 2017, 06-01, Volume: 17, Issue:4

    Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Diphosphates; Diterpenes; Gene Expression Regulation, Fungal; Geranyltranstransferase; Hemiterpenes; Kinetics; Metabolic Engineering; Molecular Docking Simulation; Organophosphorus Compounds; Point Mutation; Polyisoprenyl Phosphates; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Sesquiterpenes; Substrate Specificity; Terpenes; Thermodynamics

2017
Engineering Saccharomyces cerevisiae for geranylgeraniol overproduction by combinatorial design.
    Scientific reports, 2017, 11-08, Volume: 7, Issue:1

    Topics: Bacterial Proteins; Biosynthetic Pathways; Diterpenes; Farnesyltranstransferase; Hemiterpenes; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Metabolic Engineering; Organophosphorus Compounds; Polyisoprenyl Phosphates; Promoter Regions, Genetic; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sesquiterpenes

2017
Identifying Structural Determinants of Product Specificity in
    Biochemistry, 2020, 07-28, Volume: 59, Issue:29

    Topics: Binding Sites; Crystallography, X-Ray; Diphosphates; Diterpenes; Geranyltranstransferase; Hemiterpenes; Humans; Leishmania major; Leishmaniasis, Cutaneous; Models, Molecular; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Conformation; Sesquiterpenes; Substrate Specificity

2020