Compounds > isopentenyl pyrophosphate

isopentenyl pyrophosphate and 3,3-dimethylallyl pyrophosphate

isopentenyl pyrophosphate has been researched along with 3,3-dimethylallyl pyrophosphate in 96 studies

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.08)18.7374
1990's6 (6.25)18.2507
2000's33 (34.38)29.6817
2010's50 (52.08)24.3611
2020's5 (5.21)2.80

Authors

AuthorsStudies
Gossman, W; Oldfield, E1
Hirsch, AK; Masini, T1
Agabiti, SS; Hsiao, CC; Li, V; Liu, C; Poe, MM; Teske, KA; Wiemer, AJ1
Dennis, MS; Light, DR1
Dennis, MS; Lazarus, RA; Light, DR1
Delourme, D; Karst, F; Lacroute, F1
Christensen, DJ; Poulter, CD1
Knani, M; Rohmer, M; Sahm, H; Simonin, P; Sutter, B1
Champagne, E; Dieli, F; Fourniè, JJ; Salerno, A; Sireci, G1
Fliesler, SJ; Keller, RK1
Boronat, A; Campos, N; Grosdemange-Billiard, C; Hoeffler, JF; Maldonado, C; María Lois, L; Rodríguez-Concepción, M; Rohmer, M1
Baker, JA; Leyes, AE; Poulter, CD1
Cunningham, FX; Gantt, E; Lafond, TP1
Heuser, T; Miller, B; Zimmer, W1
Boronat, A; Campos, N; Gallego, F; Lois, LM; Rodríguez-Concepción, M; Sauret-Güeto, S1
Altincicek, B; Beck, E; Hintz, M; Jomaa, H; Kollas, AK; Sanderbrand, S; Wiesner, J1
Lichtenthaler, HK; Zeidler, J1
Kuzuyama, T; Seto, H; Takagi, M1
Bach, TJ; Grosdemange-Billiard, C; Hemmerlin, A; Hoeffler, JF; Rohmer, M1
Croteau, RB; Mahmoud, SS1
Cunningham, FX; Ershov, YV; Gantt, E; Gantt, RR1
Adam, P; Arigoni, D; Bacher, A; Eisenreich, W; Grawert, T; Hecht, S; Kaiser, J; Rohdich, F1
Bick, JA; Lange, BM1
Carter, OA; Croteau, R; Peters, RJ1
Arigoni, D; Findeisen, M; Hennig, L; Köhler, C; Neundorf, I; Welzel, P1
Cunningham, FX; Ershov, YV; Gantt, E; Gantt, RR; Poliquin, K; Woreta, TT1
Bacher, A; Eisenreich, W; Rohdich, F1
Barkley, SJ; Desai, SB; Poulter, CD1
Dordick, JS; Jeong, JC; Ku, B; Mijts, BN; Schmidt-Dannert, C1
Poulter, CD; Wouters, J; Wu, Z1
Beyer, P; Kloer, DP; Schulz, GE; Welsch, R1
Adam, P; Amslinger, S; Bacher, A; Bauer, S; Eisenreich, W; Hecht, S; Rohdich, F1
Christianson, DW1
Walsh, CT1
Das, A; Kim, JY; Kim, SW; Lee, SH; Oh, DK; Yoon, SH1
Fujiwara, S; Fukuda, W; Fukusaki, E; Higashibata, H; Hirooka, K; Imanaka, T; Nakayama, J; Yamada, Y; Yamanaka, A1
Jauhiainen, M; Mönkkönen, H; Mönkkönen, J; Roelofs, AJ; Rogers, MJ; Thompson, K1
Demmer, U; Duin, EC; Ermler, U; Hintz, M; Jomaa, H; No, JH; Oldfield, E; Rekittke, I; Röhrich, R; Troschke, K; Warkentin, E; Wiesner, J; Xu, W1
Charbonneau, AL; Larson, M; Last, RL; Pichersky, E; Schauvinhold, I; Schilmiller, AL; Schmidt, A; Wilkerson, C; Xu, R1
Bohlmann, J; Gershenzon, J1
Bacher, A; Eisenreich, W; Eppinger, J; Gräwert, T; Groll, M; Rohdich, F; Span, I1
Auriola, S; Jauhiainen, M; Mönkkönen, H; Mönkkönen, J; Räikkönen, J1
Bitok, JK; Freel Meyers, CL; Hassis-LeBeau, ME; Majumdar, A; Shah, MH1
Bach, TJ; Hemmerlin, A; Rohmer, M; Tritsch, D1
Choi, ES; Chung, YR; Keasling, JD; Kim, JY; Kim, SW; Shah, AA; Wang, C; Yoon, SH1
Ajikumar, PK; Leonard, E; Mo, JD; Prather, KL; Stephanopoulos, G; Thayer, K; Tidor, B; Xiao, WH1
Khosla, C; Liu, T1
Ajikumar, PK; Leonard, E; Mucha, O; Pfeifer, B; Phon, TH; Simeon, F; Stephanopoulos, G; Tyo, KE; Wang, Y; Xiao, WH1
Bacher, A; Eisenreich, W; Eppinger, J; Gräwert, T; Groll, M; Lee, M; Quitterer, F; Rohdich, F1
Heaps, NA; Poulter, CD2
Hunter, WN1
Hemmi, H1
Bouzid, S; Clastre, M; Courdavault, V; Dutilleul, C; Giglioli-Guivarc'h, N; Godet, S; Guirimand, G; Papon, N; Simkin, AJ; Thabet, I1
Bacher, A; Eisenreich, W; Gräwert, T; Groll, M; Span, I1
Fall, R; Rosenstiel, TN; Sivy, TL1
Goda, S; Hemmi, H; Nagai, T; Nakatani, H; Unno, H; Yoshimura, T1
Johnson, LJ; Testa, CA1
Aboge, G; Aboulaila, M; Cao, S; Igarashi, I; Nishikawa, Y; Terkawi, MA; Ueno, A; Xuan, X; Yokoyama, M; Yokoyama, N1
Arens, J; Engels, B; Jennewein, S; Klopries, S; Ottmann, C; Schulz, F1
Banerjee, A; Banerjee, R; Li, Y; Sharkey, TD; Wu, Y; Yan, H1
Chang, WC; Liu, HW; Liu, P; Xiao, Y; Zhao, L1
Li, Z; Sharkey, TD; Weise, SE; Wiberley-Bradford, AE; Zhou, C1
Chang, WC; Liu, HW; Liu, P; Song, H1
Chen, X; Stephanopoulos, G; Too, HP; Zhang, C; Zhou, K; Zou, R1
Cope, EK; Dhungana, S; Finney, KB; Fox, DT; Koppisch, AT; Leid, JG; Phillips, PD; Schmidt, EN; Testa, CA; Tian, H; Valentine, MC; Warrington, NV1
Banerjee, A; Sharkey, TD1
Baran, PS; Carbullido, MK; Diethelm, S; Kaysser, L; Moore, BS; Teufel, R; Villaume, MT1
Formighieri, C; Melis, A1
Beekwilder, J; Heider, SA; Peters-Wendisch, P; Wendisch, VF1
Coates, RM; Davis, CE; Krasutsky, SG; Lherbet, C; Poulter, CD; Urbansky, M1
Cassera, MB; Jacobs-Lorena, M; Klemba, M; Krai, PM; McLean, KJ; Merino, EF; Tripathi, AK; Vega-Rodríguez, J; Wiley, JD1
Chen, F; Gao, F; Hou, Y; Liu, C; Liu, Z; Wen, Z; Zheng, Y1
Dudareva, N; Gutensohn, M; Henry, LK; Noel, JP; Thomas, ST1
Bouwmeester, H; Dong, L; Jongedijk, E; Van Der Krol, A1
Janczak, MW; Poulter, CD1
Chaves, JE; Kirst, H; Melis, A; Romero, PR1
Banerjee, A; Preiser, AL; Sharkey, TD1
Fujii, R; Ihara, M; Kawano, Y; Kubota, G; Kudoh, K1
Han, J; Kim, M; Shin, BK1
Fujiyama, K; Kajiura, H; Kaneko, Y; Matsumura, H; Nakazawa, Y; Suzuki, N; Takeno, S; Tokumoto, Y; Yoshizawa, T1
Liu, HW; Thibodeaux, CJ1
Agosin, E; Almonacid, D; González-Nilo, F; Rubat, S; Sepúlveda, R; Varas, I1
Ding, MZ; Liu, D; Liu, H; Song, TQ; Xiao, WH; Yuan, YJ; Zhai, F1
Neti, SS; Pan, JJ; Poulter, CD1
Baidoo, EEK; Benites, VT; Joshua, CJ; Keasling, JD; Wang, G1
Tetali, SD1
Darii, E; de Berardinis, V; Duquesne, K; Iacazio, G; Mariage, A; Peruch, F; Petit, JL; Rico, J1
Bode, HB; Breitenbach, J; Buchhaupt, M; Drummond, L; Kschowak, MJ; Sandmann, G; Schrader, J; Shi, YM; Wolff, H1
Guo, D; Hua, Q; Li, D; Liu, Z; Tong, X; Wang, C; Zong, Z1
Bessman, MJ1
Gershenzon, J; Krause, T; Reichelt, M; Schmidt, A1
Amzel, LM; Aripirala, S; Gabelli, SB; Kim, YS; Maheshwari, S; Murphy, M1
Hemmi, H; Kitsuwa, K; Komeyama, M; Nakayama, A; Okamura, H; Saito, K; Shinada, T; Yasuno, Y1
Couillaud, J; Duquesne, K; Iacazio, G; Leydet, L1
Cao, X; Tang, F; Wang, J; Zhang, Y1

Reviews

13 review(s) available for isopentenyl pyrophosphate and 3,3-dimethylallyl pyrophosphate

ArticleYear
Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.
    Journal of medicinal chemistry, 2014, Dec-11, Volume: 57, Issue:23

    Topics: Aldose-Ketose Isomerases; Anti-Infective Agents; Drug Design; Enzyme Inhibitors; Erythritol; Escherichia coli Proteins; Models, Molecular; Multienzyme Complexes; Oxidoreductases; Phosphorus-Oxygen Lyases; Phosphotransferases (Alcohol Group Acceptor); Sugar Phosphates

2014
[Overlooked targets for the development of antibacterial and antimalarial drugs and herbicides: diverse biosynthetic systems for the isoprene units].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2002, Volume: 47, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antimalarials; Butadienes; Carbon-Carbon Double Bond Isomerases; Drug Design; Hemiterpenes; Herbicides; Humans; Organophosphorus Compounds; Pentanes

2002
Strategies for transgenic manipulation of monoterpene biosynthesis in plants.
    Trends in plant science, 2002, Volume: 7, Issue:8

    Topics: Genes, Plant; Hemiterpenes; Molecular Structure; Organophosphorus Compounds; Plants; Plants, Genetically Modified; Polyisoprenyl Phosphates; Terpenes; Transgenes

2002
Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.
    Bioorganic chemistry, 2004, Volume: 32, Issue:5

    Topics: Anti-Infective Agents; Bacterial Proteins; Carbon-Carbon Double Bond Isomerases; Drug Design; Hemiterpenes; Molecular Conformation; Molecular Sequence Data; Organophosphorus Compounds; Phylogeny; Terpenes

2004
An update on microbial carotenoid production: application of recent metabolic engineering tools.
    Applied microbiology and biotechnology, 2007, Volume: 77, Issue:3

    Topics: Bacteria; Biotechnology; Carotenoids; Escherichia coli; Fermentation; Genetic Engineering; Hemiterpenes; Organophosphorus Compounds

2007
Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:16

    Topics: Animals; Antiprotozoal Agents; Apicomplexa; Bacteria; Drug Delivery Systems; Drug Discovery; Enzyme Inhibitors; Enzyme Precursors; Escherichia coli Proteins; Fosfomycin; Hemiterpenes; Humans; Models, Molecular; Organophosphorus Compounds; Phosphotransferases (Alcohol Group Acceptor); Protozoan Infections; Protozoan Proteins; Radiography; Terpenes

2011
[Unique flavoenzyme: type 2 isopentenyl diphosphate isomerase].
    Seikagaku. The Journal of Japanese Biochemical Society, 2011, Volume: 83, Issue:4

    Topics: Catalysis; Flavin Mononucleotide; Hemiterpenes; Isomerases; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Conformation

2011
Methylerythritol phosphate pathway of isoprenoid biosynthesis.
    Annual review of biochemistry, 2013, Volume: 82

    Topics: Biosynthetic Pathways; Catalysis; Erythritol; Hemiterpenes; Humans; Organophosphorus Compounds; Terpenes

2013
Current development in isoprenoid precursor biosynthesis and regulation.
    Current opinion in chemical biology, 2013, Volume: 17, Issue:4

    Topics: Animals; Biosynthetic Pathways; Hemiterpenes; Humans; Mevalonic Acid; Organophosphorus Compounds; Terpenes

2013
Methylerythritol 4-phosphate (MEP) pathway metabolic regulation.
    Natural product reports, 2014, Volume: 31, Issue:8

    Topics: Bacteria; Erythritol; Hemiterpenes; Molecular Structure; Organophosphorus Compounds; Plants; Sugar Phosphates; Terpenes

2014
The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis.
    Archives of biochemistry and biophysics, 2017, 10-15, Volume: 632

    Topics: Carbon-Carbon Double Bond Isomerases; Flavoproteins; Hemiterpenes; Organophosphorus Compounds; Terpenes

2017
Terpenes and isoprenoids: a wealth of compounds for global use.
    Planta, 2019, Volume: 249, Issue:1

    Topics: Carotenoids; Chlorophyll; Hemiterpenes; Organophosphorus Compounds; Quinones; Terpenes

2019
The Terpene Mini-Path, a New Promising Alternative for Terpenoids Bio-Production.
    Genes, 2021, 12-10, Volume: 12, Issue:12

    Topics: Erythritol; Hemiterpenes; Mevalonic Acid; Organophosphorus Compounds; Terpenes

2021

Other Studies

83 other study(ies) available for isopentenyl pyrophosphate and 3,3-dimethylallyl pyrophosphate

ArticleYear
Quantitative structure--activity relations for gammadelta T cell activation by phosphoantigens.
    Journal of medicinal chemistry, 2002, Oct-24, Volume: 45, Issue:22

    Topics: Antigens, Bacterial; Lymphocyte Activation; Models, Molecular; Phosphoproteins; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes

2002
Probing the Ligand-Binding Pocket of BTN3A1.
    Journal of medicinal chemistry, 2019, 07-25, Volume: 62, Issue:14

    Topics: Antigens, CD; Binding Sites; Butyrophilins; Drug Design; Humans; Ligands; Molecular Docking Simulation; Organophosphonates; Protein Domains; Structure-Activity Relationship; T-Lymphocytes

2019
Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Amino Acid Sequence; Chromatography; Chromatography, High Pressure Liquid; Dimethylallyltranstransferase; Dithiothreitol; Hemiterpenes; Kinetics; Latex; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Organophosphorus Compounds; Plants; Polyisoprenyl Phosphates; Rubber; Sesquiterpenes; Substrate Specificity; Transferases; Trees

1989
Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Animals; Chickens; Dimethylallyltranstransferase; Hemiterpenes; Liver; Molecular Weight; Organophosphorus Compounds; Phosphates; Plants; Polyisoprenyl Phosphates; Rubber; Sesquiterpenes; Stereoisomerism; Substrate Specificity; Transferases; Trees

1989
Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast.
    Plant molecular biology, 1994, Volume: 26, Issue:6

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Arabidopsis; Base Sequence; Cloning, Molecular; DNA, Complementary; Ergosterol; Genetic Complementation Test; Geranyltranstransferase; Hemiterpenes; Molecular Sequence Data; Organophosphorus Compounds; Plant Proteins; Polyisoprenyl Phosphates; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sesquiterpenes; Transferases

1994
Enzymatic synthesis of isotopically labeled isoprenoid diphosphates.
    Bioorganic & medicinal chemistry, 1994, Volume: 2, Issue:7

    Topics: Alkyl and Aryl Transferases; Animals; Birds; Carbon Isotopes; Carbon-Carbon Double Bond Isomerases; Escherichia coli; Farnesyltranstransferase; Hemiterpenes; Indicators and Reagents; Isomerases; Isotope Labeling; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Polyisoprenyl Phosphates; Recombinant Proteins; Saccharomyces cerevisiae; Sesquiterpenes; Transferases

1994
Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate.
    The Biochemical journal, 1993, Oct-15, Volume: 295 ( Pt 2)

    Topics: Bacteria; Carbon Isotopes; Hemiterpenes; Magnetic Resonance Spectroscopy; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Terpenes

1993
Patterns of phosphoantigen stimulation of human Vgamma9/Vdelta2 T cell clones include Th0 cytokines.
    Human immunology, 1997, Volume: 58, Issue:2

    Topics: Antibodies, Bacterial; Antibodies, Monoclonal; Antigen-Presenting Cells; Antigens, Bacterial; Clone Cells; Cytokines; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Hemiterpenes; Hexosephosphates; Humans; Interferon-gamma; Interleukin-12; Interleukin-2; Interleukin-4; Lymphocyte Activation; Mycobacterium fortuitum; Organophosphorus Compounds; Pentosephosphates; Phosphorylation; Polymerase Chain Reaction; Receptors, Antigen, T-Cell, gamma-delta; Ribosemonophosphates; T-Lymphocytes; Transcription, Genetic; Tumor Necrosis Factor-alpha

1997
Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway.
    Biochemical and biophysical research communications, 1999, Dec-20, Volume: 266, Issue:2

    Topics: Alendronate; Alkyl and Aryl Transferases; Animals; Chromatography, High Pressure Liquid; Cytosol; Geranyltranstransferase; Hemiterpenes; Kinetics; Liver; Male; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Sesquiterpenes

1999
Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli.
    FEBS letters, 2000, May-19, Volume: 473, Issue:3

    Topics: Arabinose; Carbon-Carbon Double Bond Isomerases; Escherichia coli; Hemiterpenes; Mevalonic Acid; Mutagenesis, Insertional; Organophosphorus Compounds; Polymerase Chain Reaction

2000
Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase.
    Organic letters, 1999, Oct-07, Volume: 1, Issue:7

    Topics: Alkyl and Aryl Transferases; Animals; Catalysis; Chickens; Escherichia coli; Geranyltranstransferase; Hemiterpenes; Organophosphorus Compounds; Stereoisomerism; Swine

1999
Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis.
    Journal of bacteriology, 2000, Volume: 182, Issue:20

    Topics: Amino Acid Sequence; Bacterial Proteins; Cyanobacteria; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Molecular Sequence Data; Organophosphorus Compounds; Oxidoreductases; Pentosephosphates; Promoter Regions, Genetic; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid; Transferases

2000
Functional involvement of a deoxy-D-xylulose 5-phosphate reductoisomerase gene harboring locus of Synechococcus leopoliensis in isoprenoid biosynthesis.
    FEBS letters, 2000, Sep-22, Volume: 481, Issue:3

    Topics: Aldose-Ketose Isomerases; Bacterial Proteins; Cosmids; Cyanobacteria; Erythritol; Gene Amplification; Gene Library; Genes, Bacterial; Genetic Markers; Hemiterpenes; Hydro-Lyases; Multienzyme Complexes; Oligonucleotide Probes; Open Reading Frames; Operon; Organophosphorus Compounds; Oxidoreductases; Polyisoprenyl Phosphates; Recombinant Fusion Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sugar Phosphates; Transferases

2000
Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis.
    The Biochemical journal, 2001, Jan-01, Volume: 353, Issue:Pt 1

    Topics: Bacterial Proteins; Carbon-Carbon Double Bond Isomerases; Carboxy-Lyases; Chromosomes, Bacterial; DNA, Recombinant; Erythritol; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Genes, Bacterial; Genes, Essential; Genes, Fungal; Genes, Lethal; Genetic Engineering; Hemiterpenes; Humans; Mevalonic Acid; Nucleotidyltransferases; Operon; Organophosphorus Compounds; Phenotype; Phosphorus-Oxygen Lyases; Phosphotransferases (Alcohol Group Acceptor); Phosphotransferases (Phosphate Group Acceptor); Polyisoprenyl Phosphates; Recombination, Genetic; Sugar Phosphates

2001
GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.
    Journal of bacteriology, 2001, Volume: 183, Issue:8

    Topics: Amino Acid Sequence; Bacterial Proteins; Enzymes; Erythritol; Escherichia coli; Gene Deletion; Genetic Complementation Test; Hemiterpenes; Mevalonic Acid; Molecular Sequence Data; Organophosphorus Compounds; Sugar Phosphates

2001
Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation.
    Planta, 2001, Volume: 213, Issue:2

    Topics: Hemiterpenes; Mevalonic Acid; Organophosphorus Compounds; Pentanols; Pinus; Pinus ponderosa; Terpenes; Xylulose

2001
Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate.
    The Biochemical journal, 2002, Sep-01, Volume: 366, Issue:Pt 2

    Topics: Cell Line; Escherichia coli; Hemiterpenes; Indicators and Reagents; Nicotiana; Organophosphorus Compounds; Plants; Polyisoprenyl Phosphates; Tritium

2002
Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate.
    Journal of bacteriology, 2002, Volume: 184, Issue:18

    Topics: Carbon Radioisotopes; Carbon-Carbon Double Bond Isomerases; Culture Media; Cyanobacteria; Fosfomycin; Hemiterpenes; Organophosphorus Compounds; Pentose Phosphate Pathway; Pentosephosphates; Photosynthesis; Pyruvic Acid

2002
Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Sep-17, Volume: 99, Issue:19

    Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Capsicum; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Molecular Sequence Data; Organophosphorus Compounds; Oxidoreductases; Recombinant Proteins; Sequence Homology, Amino Acid; Terpenes

2002
Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane.
    Archives of biochemistry and biophysics, 2003, Jul-15, Volume: 415, Issue:2

    Topics: Biological Transport; Brassica; Calcium; Chloroplasts; Cytosol; Energy Metabolism; Hemiterpenes; Intracellular Membranes; Mustard Plant; Organophosphorus Compounds; Spinacia oleracea

2003
Monoterpene biosynthesis pathway construction in Escherichia coli.
    Phytochemistry, 2003, Volume: 64, Issue:2

    Topics: Alcohol Oxidoreductases; Alkyl and Aryl Transferases; Cyclohexane Monoterpenes; Cyclohexenes; Cytochrome P-450 Enzyme System; Escherichia coli; Escherichia coli Proteins; Gene Expression; Genes, Bacterial; Hemiterpenes; Intramolecular Lyases; Limonene; Mixed Function Oxygenases; Monoterpenes; NADPH-Ferrihemoprotein Reductase; Organophosphorus Compounds; Plant Proteins; Recombinant Proteins; Terpenes

2003
Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics.
    Chembiochem : a European journal of chemical biology, 2003, Nov-07, Volume: 4, Issue:11

    Topics: Anti-Bacterial Agents; Hemiterpenes; Magnetic Resonance Spectroscopy; Molecular Structure; Oligosaccharides; Organophosphorus Compounds; Streptomyces; Terpenes; Xylulose

2003
Inactivation of sll1556 in Synechocystis strain PCC 6803 impairs isoprenoid biosynthesis from pentose phosphate cycle substrates in vitro.
    Journal of bacteriology, 2004, Volume: 186, Issue:14

    Topics: Bacterial Proteins; Carotenoids; Cell Wall; Chlorophyll; Cyanobacteria; Fructosephosphates; Gene Silencing; Genes, Bacterial; Glucose-6-Phosphate; Glyceraldehyde 3-Phosphate; Hemiterpenes; Mutagenesis, Insertional; Organophosphorus Compounds; Pentose Phosphate Pathway; Terpenes; Thylakoids

2004
Proton exchange in type II isopentenyl diphosphate isomerase.
    Organic letters, 2004, Dec-23, Volume: 6, Issue:26

    Topics: Carbon-Carbon Double Bond Isomerases; Catalysis; Enzyme Activation; Hemiterpenes; Organophosphorus Compounds; Protons; Stereoisomerism; Synechocystis

2004
Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway.
    Applied and environmental microbiology, 2005, Volume: 71, Issue:11

    Topics: Bacterial Proteins; Biotechnology; Carotenoids; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Farnesyl-Diphosphate Farnesyltransferase; Geranyltranstransferase; Hemiterpenes; Kinetics; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes

2005
Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate.
    Journal of the American Chemical Society, 2005, Dec-14, Volume: 127, Issue:49

    Topics: Carbon-Carbon Double Bond Isomerases; Escherichia coli; Hemiterpenes; Kinetics; Molecular Structure; Organophosphorus Compounds; Schizosaccharomyces

2005
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba.
    Biochemistry, 2006, Dec-26, Volume: 45, Issue:51

    Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Diterpenes; Escherichia coli; Farnesyltranstransferase; Hemiterpenes; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sesquiterpenes; Sinapis; Substrate Specificity

2006
Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate.
    Immunobiology, 2007, Volume: 212, Issue:1

    Topics: Antigens, Bacterial; Cell Proliferation; Cells, Cultured; Hemiterpenes; Humans; Lymphocyte Activation; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; T-Lymphocytes; Terpenes

2007
Chemistry. Roots of biosynthetic diversity.
    Science (New York, N.Y.), 2007, Apr-06, Volume: 316, Issue:5821

    Topics: Amino Acid Substitution; Binding Sites; Evolution, Molecular; Geranyltranstransferase; Hemiterpenes; Organophosphorus Compounds; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Terpenes

2007
Revealing coupling patterns in isoprenoid alkylation biocatalysis.
    ACS chemical biology, 2007, May-22, Volume: 2, Issue:5

    Topics: Alkylation; Catalysis; Dimerization; Farnesyltranstransferase; Geranyltranstransferase; Hemiterpenes; Isomerism; Molecular Structure; Organophosphorus Compounds; Terpenes

2007
Efficient synthesis of trans-polyisoprene compounds using two thermostable enzymes in an organic-aqueous dual-liquid phase system.
    Biochemical and biophysical research communications, 2008, Jan-04, Volume: 365, Issue:1

    Topics: Archaeal Proteins; Carbon-Carbon Double Bond Isomerases; Circular Dichroism; Hemiterpenes; Isomerism; Models, Biological; Organophosphorus Compounds; Phase Transition; Polyisoprenyl Phosphates; Temperature; Thermococcus

2008
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.
    British journal of haematology, 2009, Volume: 144, Issue:2

    Topics: Cell Communication; Cells, Cultured; Diphosphonates; Hemiterpenes; Humans; Imidazoles; Lymphocyte Activation; Monocytes; Organophosphorus Compounds; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Zoledronic Acid

2009
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway.
    Journal of the American Chemical Society, 2008, Dec-24, Volume: 130, Issue:51

    Topics: Amino Acid Sequence; Animals; Bacteria; Catalysis; Evolution, Molecular; Hemiterpenes; Mevalonic Acid; Models, Chemical; Molecular Conformation; Molecular Sequence Data; Organophosphorus Compounds; Oxidoreductases; Plasmodium falciparum; Sequence Homology, Amino Acid; Terpenes

2008
Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Jun-30, Volume: 106, Issue:26

    Topics: Alkyl and Aryl Transferases; Biosynthetic Pathways; Cloning, Molecular; Cyclohexane Monoterpenes; Dimethylallyltranstransferase; Diphosphates; Diterpenes; DNA, Complementary; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Plant; Gene Library; Hemiterpenes; Kinetics; Molecular Sequence Data; Molecular Structure; Monoterpenes; Organophosphorus Compounds; Plant Epidermis; Plant Proteins; Polyisoprenyl Phosphates; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Solanum lycopersicum; Substrate Specificity

2009
Old substrates for new enzymes of terpenoid biosynthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Jun-30, Volume: 106, Issue:26

    Topics: Alkyl and Aryl Transferases; Dimethylallyltranstransferase; Hemiterpenes; Monoterpenes; Organophosphorus Compounds; Plant Epidermis; Plant Proteins; Polyisoprenyl Phosphates; Solanum lycopersicum; Substrate Specificity

2009
Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction.
    Angewandte Chemie (International ed. in English), 2009, Volume: 48, Issue:31

    Topics: Biocatalysis; Catalytic Domain; Electron Transport; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Organophosphorus Compounds; Oxidoreductases; Protein Structure, Tertiary; Recombinant Proteins

2009
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Oct-01, Volume: 877, Issue:27

    Topics: Adenosine Triphosphate; Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Drug Stability; Hemiterpenes; Humans; Linear Models; Mevalonic Acid; Organophosphorus Compounds; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2009
Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using (1)H-(31)P-(31)P correlation NMR spectroscopy.
    Molecular bioSystems, 2009, Volume: 5, Issue:9

    Topics: Aldose-Ketose Isomerases; Erythritol; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Isotope Labeling; Metabolic Networks and Pathways; Multienzyme Complexes; Nuclear Magnetic Resonance, Biomolecular; Organophosphorus Compounds; Oxidoreductases; Phosphorus Isotopes; Phosphorus-Oxygen Lyases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Terpenes

2009
Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures.
    FEBS letters, 2010, Jan-04, Volume: 584, Issue:1

    Topics: Cell Culture Techniques; Cells, Cultured; Erythritol; Hemiterpenes; Nicotiana; Organophosphorus Compounds; Plastids; Sugar Phosphates; Terpenes; Xylulose

2010
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway.
    Biotechnology and bioengineering, 2010, Oct-15, Volume: 107, Issue:3

    Topics: Culture Media; Escherichia coli; Farnesol; Gene Dosage; Gene Expression; Geranyltranstransferase; Hemiterpenes; Metabolic Networks and Pathways; Mevalonic Acid; Organophosphorus Compounds; Plasmids; Polyisoprenyl Phosphates; Sesquiterpenes

2010
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-03, Volume: 107, Issue:31

    Topics: Alkyl and Aryl Transferases; Escherichia coli; Farnesyltranstransferase; Hemiterpenes; Molecular Structure; Mutation; Organophosphorus Compounds; Protein Engineering; Terpenes

2010
Chemistry. A balancing act for Taxol precursor pathways in E. coli.
    Science (New York, N.Y.), 2010, Oct-01, Volume: 330, Issue:6000

    Topics: Alkenes; Diterpenes; Escherichia coli; Farnesyltranstransferase; Fermentation; Genetic Engineering; Glucose; Hemiterpenes; Isomerases; Metabolic Networks and Pathways; NADPH-Ferrihemoprotein Reductase; Organophosphorus Compounds; Paclitaxel; Recombinant Fusion Proteins; Taxus

2010
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.
    Science (New York, N.Y.), 2010, Oct-01, Volume: 330, Issue:6000

    Topics: Alkenes; Bioreactors; Cytochrome P-450 Enzyme System; Diterpenes; Erythritol; Escherichia coli K12; Farnesyltranstransferase; Fermentation; Genetic Engineering; Hemiterpenes; Indoles; Isomerases; Metabolic Networks and Pathways; Metabolomics; NADPH-Ferrihemoprotein Reductase; Organophosphorus Compounds; Oxidation-Reduction; Paclitaxel; Recombinant Fusion Proteins; Sugar Phosphates; Taxoids; Taxus; Terpenes

2010
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG.
    Journal of molecular biology, 2010, Dec-10, Volume: 404, Issue:4

    Topics: Bacteria; Bacterial Proteins; Crystallography, X-Ray; Hemiterpenes; Models, Molecular; Organophosphorus Compounds; Protein Multimerization; Protein Structure, Quaternary; Protein Subunits; Terpenes

2010
Synthesis and evaluation of chlorinated substrate analogues for farnesyl diphosphate synthase.
    The Journal of organic chemistry, 2011, Mar-18, Volume: 76, Issue:6

    Topics: Animals; Geranyltranstransferase; Halogenation; Hemiterpenes; Kinetics; Models, Molecular; Organophosphorus Compounds; Protein Conformation

2011
The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis.
    Journal of plant physiology, 2011, Nov-15, Volume: 168, Issue:17

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Biological Transport; Catharanthus; Cloning, Molecular; DNA, Complementary; Genetic Complementation Test; Geranyltranstransferase; Hemiterpenes; Luminescent Proteins; Molecular Sequence Data; Organophosphorus Compounds; Peroxisomes; Recombinant Fusion Proteins; RNA, Plant; Saccharomyces cerevisiae; Sequence Analysis, DNA; Sequence Deletion; Terpenes

2011
Type-2 isopentenyl diphosphate isomerase: evidence for a stepwise mechanism.
    Journal of the American Chemical Society, 2011, Nov-30, Volume: 133, Issue:47

    Topics: Biocatalysis; Carbon-Carbon Double Bond Isomerases; Hemiterpenes; Molecular Structure; Organophosphorus Compounds; Thermus thermophilus

2011
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis.
    Journal of molecular biology, 2012, Feb-10, Volume: 416, Issue:1

    Topics: Catalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Iron-Sulfur Proteins; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Oxidoreductases; Protein Binding; Protein Conformation; Structure-Activity Relationship; Terpenes; Water

2012
Evidence of isoprenoid precursor toxicity in Bacillus subtilis.
    Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:12

    Topics: Bacillus subtilis; Butadienes; Carbon-Carbon Double Bond Isomerases; Cell Proliferation; Cytotoxins; Erythritol; Fosfomycin; Genetic Engineering; Hemiterpenes; Organophosphorus Compounds; Pentanes; Sequence Deletion; Sugar Phosphates; Terpenes

2011
Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae.
    Journal of bacteriology, 2012, Volume: 194, Issue:12

    Topics: Allosteric Regulation; Carbon-Carbon Double Bond Isomerases; Chromatography, Gel; Crystallography, X-Ray; Hemiterpenes; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphorus Compounds; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Sulfolobus

2012
A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9

    Topics: Anti-Bacterial Agents; Biosynthetic Pathways; Cell Membrane Permeability; Fosfomycin; Hemiterpenes; High-Throughput Screening Assays; Metabolic Engineering; Microbial Sensitivity Tests; Organophosphorus Compounds; Salmonella typhimurium; Terpenes

2012
Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis.
    Parasitology international, 2013, Volume: 62, Issue:2

    Topics: Animals; Babesia bovis; Cloning, Molecular; DNA, Complementary; DNA, Protozoan; Etidronic Acid; Geranyltranstransferase; Hemiterpenes; Inhibitory Concentration 50; Kinetics; Mice; Molecular Weight; Organophosphorus Compounds; Parasitemia; Protozoan Proteins; Risedronic Acid; Sequence Analysis, DNA

2013
Exploration of biosynthetic access to the shared precursor of the fusicoccane diterpenoid family.
    Chemical communications (Cambridge, England), 2013, May-14, Volume: 49, Issue:39

    Topics: Alternaria; Biocatalysis; Cladosporium; Diterpenes; Fungal Proteins; Hemiterpenes; Organophosphorus Compounds

2013
Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway.
    The Journal of biological chemistry, 2013, Jun-07, Volume: 288, Issue:23

    Topics: Erythritol; Escherichia coli; Hemiterpenes; Kinetics; Models, Molecular; Organophosphorus Compounds; Plant Proteins; Populus; Protein Binding; Recombinant Proteins; Sugar Phosphates; Thiamine Pyrophosphate; Transferases

2013
Isopentenyl diphosphate and dimethylallyl diphosphate/isopentenyl diphosphate ratio measured with recombinant isopentenyl diphosphate isomerase and isoprene synthase.
    Analytical biochemistry, 2013, Sep-15, Volume: 440, Issue:2

    Topics: Alkyl and Aryl Transferases; Carbon-Carbon Double Bond Isomerases; Escherichia coli; Hemiterpenes; Organophosphorus Compounds; Plant Leaves; Pueraria; Recombinant Proteins; Transformation, Genetic

2013
Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Alkyl and Aryl Transferases; Geranyltranstransferase; Hemiterpenes; Mevalonic Acid; Organophosphorus Compounds; Polycyclic Sesquiterpenes; Polyisoprenyl Phosphates; Research Design; Sesquiterpenes

2013
Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Anti-Bacterial Agents; Biosynthetic Pathways; Fosfomycin; Gene Expression Regulation, Bacterial; Hemiterpenes; Humans; Hydrogen Peroxide; Kanamycin; Microbial Sensitivity Tests; Oligonucleotide Array Sequence Analysis; Organophosphorus Compounds; Oxidative Stress; Salmonella typhimurium; Time Factors

2014
One-pot enzymatic synthesis of merochlorin A and B.
    Angewandte Chemie (International ed. in English), 2014, Oct-06, Volume: 53, Issue:41

    Topics: Bacterial Proteins; Cyclization; Hemiterpenes; Organophosphorus Compounds; Sesterterpenes; Streptomyces; Terpenes

2014
Carbon partitioning to the terpenoid biosynthetic pathway enables heterologous β-phellandrene production in Escherichia coli cultures.
    Archives of microbiology, 2014, Volume: 196, Issue:12

    Topics: Biosynthetic Pathways; Carbon; Cyclohexane Monoterpenes; Cyclohexenes; Erythritol; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Lavandula; Mevalonic Acid; Monoterpenes; Organophosphorus Compounds; Picea; Recombinant Proteins; Sugar Phosphates; Synechocystis; Terpenes; Transformation, Bacterial

2014
IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum.
    The FEBS journal, 2014, Volume: 281, Issue:21

    Topics: Bacterial Proteins; Carotenoids; Corynebacterium glutamicum; Dimethylallyltranstransferase; Escherichia coli; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Complementation Test; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Hemiterpenes; Industrial Microbiology; Organophosphorus Compounds; Phylogeny; Recombinant Fusion Proteins; Sequence Alignment; Substrate Specificity; Xanthophylls

2014
Synthesis of methylerythritol phosphate analogues and their evaluation as alternate substrates for IspDF and IspE from Agrobacterium tumefaciens.
    The Journal of organic chemistry, 2014, Oct-03, Volume: 79, Issue:19

    Topics: Agrobacterium tumefaciens; Bacterial Proteins; Catalysis; Enzyme Assays; Erythritol; Hemiterpenes; Magnetic Resonance Spectroscopy; Molecular Structure; Multienzyme Complexes; Organophosphorus Compounds; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity; Sugar Phosphates

2014
Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.
    Eukaryotic cell, 2015, Volume: 14, Issue:2

    Topics: Animals; Apicoplasts; Gametogenesis; Hemiterpenes; Life Cycle Stages; Organophosphorus Compounds; Plasmodium falciparum

2015
Ethanol induced astaxanthin accumulation and transcriptional expression of carotenogenic genes in Haematococcus pluvialis.
    Enzyme and microbial technology, 2015, Volume: 78

    Topics: Algal Proteins; Antioxidants; Carbon-Carbon Double Bond Isomerases; Ethanol; Gene Expression; Hemiterpenes; Light; Microscopy, Electron, Scanning; Organophosphorus Compounds; Real-Time Polymerase Chain Reaction; Substrate Specificity; Volvocida; Xanthophylls

2015
Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-11, Volume: 112, Issue:32

    Topics: Arabidopsis; Arabidopsis Proteins; Archaea; Cytosol; Gene Expression Regulation, Plant; Gene Knockout Techniques; Genes, Plant; Hemiterpenes; Kinetics; Metabolic Networks and Pathways; Mevalonic Acid; Nicotiana; Organophosphorus Compounds; Phosphotransferases (Alcohol Group Acceptor); Plants, Genetically Modified; Plastids; Polyisoprenyl Phosphates; Sequence Homology, Amino Acid; Sesquiterpenes; Terpenes

2015
Monoterpene biosynthesis potential of plant subcellular compartments.
    The New phytologist, 2016, Volume: 209, Issue:2

    Topics: Acyclic Monoterpenes; Cytosol; Diphosphates; Diterpenes; Geranyltranstransferase; Hemiterpenes; Mitochondria; Monoterpenes; Nicotiana; Organophosphorus Compounds; Phosphoric Monoester Hydrolases; Picea; Plant Proteins; Plants, Genetically Modified; Plastids; Terpenes; Valerian

2016
Kinetic and Binding Studies of Streptococcus pneumoniae Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase.
    Biochemistry, 2016, Apr-19, Volume: 55, Issue:15

    Topics: Aerobiosis; Carbon-Carbon Double Bond Isomerases; Crystallography, X-Ray; Flavin Mononucleotide; Flavins; Hemiterpenes; Hydroquinones; Kinetics; Models, Molecular; Organophosphorus Compounds; Protein Binding; Spectrophotometry, Ultraviolet; Streptococcus pneumoniae

2016
Role of isopentenyl-diphosphate isomerase in heterologous cyanobacterial (Synechocystis) isoprene production.
    Photosynthesis research, 2016, Volume: 130, Issue:1-3

    Topics: Butadienes; Gene Expression Regulation, Bacterial; Hemiterpenes; Isomerases; Metabolic Engineering; Organophosphorus Compounds; Pentanes; Synechocystis; Synthetic Biology

2016
Engineering of Recombinant Poplar Deoxy-D-Xylulose-5-Phosphate Synthase (PtDXS) by Site-Directed Mutagenesis Improves Its Activity.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Alanine; Amino Acid Sequence; Catalytic Domain; Enzyme Inhibitors; Feedback, Physiological; Gene Expression; Glycine; Hemiterpenes; Kinetics; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Organophosphorus Compounds; Plant Proteins; Populus; Protein Binding; Protein Engineering; Protein Interaction Domains and Motifs; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Thiamine Pyrophosphate; Transferases

2016
Exploration of the 1-deoxy-d-xylulose 5-phosphate synthases suitable for the creation of a robust isoprenoid biosynthesis system.
    Journal of bioscience and bioengineering, 2017, Volume: 123, Issue:3

    Topics: Bacillus subtilis; Enzyme Stability; Erythritol; Escherichia coli; Hemiterpenes; Organophosphorus Compounds; Paracoccus; Pentosephosphates; Peptide Hydrolases; Rhodobacter capsulatus; Solubility; Sugar Phosphates; Synechocystis; Terpenes; Transferases

2017
Exceptionally high percentage of IPP synthesis by Ginkgo biloba IspH is mainly due to Phe residue in the active site.
    Phytochemistry, 2017, Volume: 136

    Topics: Catalytic Domain; Chloroplasts; Ginkgo biloba; Hemiterpenes; Iron; Molecular Sequence Data; Molecular Structure; Organophosphates; Organophosphorus Compounds; Protein Conformation; Stereoisomerism; Sulfides

2017
Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences.
    Biochimie, 2017, Volume: 139

    Topics: Amino Acid Sequence; Eucommiaceae; Geranyltranstransferase; Hemiterpenes; Kinetics; Models, Molecular; Organophosphorus Compounds; Polyisoprenyl Phosphates; Sequence Homology, Amino Acid; Sesquiterpenes; Substrate Specificity

2017
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase.
    FEMS yeast research, 2017, 06-01, Volume: 17, Issue:4

    Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Diphosphates; Diterpenes; Gene Expression Regulation, Fungal; Geranyltranstransferase; Hemiterpenes; Kinetics; Metabolic Engineering; Molecular Docking Simulation; Organophosphorus Compounds; Point Mutation; Polyisoprenyl Phosphates; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Sesquiterpenes; Substrate Specificity; Terpenes; Thermodynamics

2017
Engineering Saccharomyces cerevisiae for geranylgeraniol overproduction by combinatorial design.
    Scientific reports, 2017, 11-08, Volume: 7, Issue:1

    Topics: Bacterial Proteins; Biosynthetic Pathways; Diterpenes; Farnesyltranstransferase; Hemiterpenes; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Metabolic Engineering; Organophosphorus Compounds; Polyisoprenyl Phosphates; Promoter Regions, Genetic; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sesquiterpenes

2017
Mechanistic Studies of the Protonation-Deprotonation Reactions for Type 1 and Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase.
    Journal of the American Chemical Society, 2018, 10-10, Volume: 140, Issue:40

    Topics: Carbon-Carbon Double Bond Isomerases; Deuterium; Escherichia coli; Escherichia coli Proteins; Hemiterpenes; Isomerism; Models, Molecular; Organophosphorus Compounds; Protons; Streptococcus pneumoniae

2018
Liquid Chromatography and Mass Spectrometry Analysis of Isoprenoid Intermediates in Escherichia coli.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1859

    Topics: Biosynthetic Pathways; Chromatography, Liquid; Escherichia coli; Hemiterpenes; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Metabolic Engineering; Metabolomics; Organisms, Genetically Modified; Organophosphorus Compounds

2019
Exploring natural biodiversity to expand access to microbial terpene synthesis.
    Microbial cell factories, 2019, Feb-01, Volume: 18, Issue:1

    Topics: Archaea; Bacteria; Batch Cell Culture Techniques; Biodiversity; Carotenoids; Erythritol; Escherichia coli; Hemiterpenes; Metabolic Engineering; Mevalonic Acid; Organophosphorus Compounds; Terpenes

2019
Expanding the Isoprenoid Building Block Repertoire with an IPP Methyltransferase from Streptomyces monomycini.
    ACS synthetic biology, 2019, 06-21, Volume: 8, Issue:6

    Topics: Bacterial Proteins; Escherichia coli; Hemiterpenes; Metabolic Engineering; Metabolic Networks and Pathways; Methyltransferases; Organophosphorus Compounds; Streptomyces; Terpenes

2019
Biosynthesis of nerol from glucose in the metabolic engineered Escherichia coli.
    Bioresource technology, 2019, Volume: 287

    Topics: Acyclic Monoterpenes; Escherichia coli; Glucose; Hemiterpenes; Metabolic Engineering; Organophosphorus Compounds; Polyisoprenyl Phosphates; Terpenes

2019
A cryptic activity in the Nudix hydrolase superfamily.
    Protein science : a publication of the Protein Society, 2019, Volume: 28, Issue:8

    Topics: Diphosphates; Escherichia coli; Hemiterpenes; Models, Molecular; Molecular Structure; Nudix Hydrolases; Organophosphorus Compounds; Pyrophosphatases

2019
Analysis of the isoprenoid pathway intermediates, dimethylallyl diphosphate and isopentenyl diphosphate, from crude plant extracts by liquid chromatography tandem mass spectrometry.
    Phytochemical analysis : PCA, 2020, Volume: 31, Issue:6

    Topics: Chromatography, Liquid; Hemiterpenes; Organophosphorus Compounds; Plant Extracts; Plants; Tandem Mass Spectrometry; Terpenes

2020
Identifying Structural Determinants of Product Specificity in
    Biochemistry, 2020, 07-28, Volume: 59, Issue:29

    Topics: Binding Sites; Crystallography, X-Ray; Diphosphates; Diterpenes; Geranyltranstransferase; Hemiterpenes; Humans; Leishmania major; Leishmaniasis, Cutaneous; Models, Molecular; Organophosphorus Compounds; Polyisoprenyl Phosphates; Protein Conformation; Sesquiterpenes; Substrate Specificity

2020
Total Synthesis and Structure Confirmation of
    Journal of natural products, 2021, 10-22, Volume: 84, Issue:10

    Topics: Aeropyrum; Hemiterpenes; Hydro-Lyases; Mevalonic Acid; Molecular Structure; Organophosphates; Organophosphorus Compounds; Terpenes

2021
Enhancement of linalool production in Saccharomyces cerevisiae by utilizing isopentenol utilization pathway.
    Microbial cell factories, 2022, Oct-15, Volume: 21, Issue:1

    Topics: Acyclic Monoterpenes; Carbon; Diphosphates; DNA Copy Number Variations; Geranyltranstransferase; Hemiterpenes; Metabolic Engineering; Mevalonic Acid; Monoterpenes; Organophosphorus Compounds; Pentanols; Saccharomyces cerevisiae

2022