isoniazid has been researched along with vitamin b 6 in 67 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 54 (80.60) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (4.48) | 29.6817 |
2010's | 8 (11.94) | 24.3611 |
2020's | 2 (2.99) | 2.80 |
Authors | Studies |
---|---|
KATO, N; OKAJIMA, M; YONEDA, M | 1 |
COSTA, E | 1 |
ASANO, N; YONEDA, M | 1 |
BOONE, IU; WOODWARD, KT | 1 |
BIEHL, JP; VILTER, RW | 2 |
MUGGLETON, PW; PARKIN, KR; TOMICH, EG; UNGAR, J | 1 |
STUDER, A; ZBINDEN, G | 1 |
BOONE, IU; LANGHAM, WH; TURNEY, DF | 1 |
LINCOLN, EM; MORALES, SM | 1 |
BOONE, IU; ROGERS, BS; STRANG, VG | 1 |
BROWN, RR; LARSON, FC; PRICE, JM | 1 |
DEUSCHLE, K; McCUNE, R; McDERMOTT, W | 1 |
BELYKH, RA; GREBENNIK, LI; SHAKHNAZAROVA, NG | 1 |
KIRSHNER, JJ | 1 |
ROSS, RR | 1 |
IANNELLO, JA; PILHEU, JA | 1 |
BERTE, SJ; DEWLETT, HJ; SCHMIDT, HW | 2 |
FRENCH, CE; HARTSOOK, EW; HERSHBERGER, TV | 1 |
GASSMANN, B; KNAPP, A; ZIMMERMANN, W | 1 |
GEOFFROY, H; KLUG, M; PASCAL, P; SLOMIC, A | 1 |
GOLDSHTEIN, VD | 1 |
Hartsook, EW; Hershberger, TV | 1 |
IRSKENS, KJ | 1 |
BOONE, IU; DES PREZ, R | 1 |
KAKINOKI, H | 1 |
LEVENE, CI | 1 |
MAREK, L | 1 |
DAVID, JD; LEAHY, DJ | 1 |
CAPANO, V; DE LORENZO, F; DELLA PIETRA, G; ROGLIANI, C | 1 |
CAPANO, V; DELLA PIETRA, G; DELORENZO, F; PROCACCINI, S | 1 |
PETZOLD, J; SCHWABE, HK; TUENNERHOFF, FK | 1 |
ALMASI, S; FESZT, T; MOZES, M | 1 |
HAWKINS, JE; STEENKEN, W | 1 |
Donald, EA; Johnston, FA | 1 |
EROSHINA, NV; GREBENNIK, LI | 1 |
BELASIO, L; CATTANEO, C; DERITIS, GC; FANTOLI, U | 1 |
CATTANEO, C; DERITIS, GC; FANTOLI, U | 1 |
GUILLERMAND, J | 1 |
DESPIERRES, G; LAGEZE, P; MALTERRE, H | 1 |
VILTER, RW | 1 |
ROSEN, F | 1 |
LICHSTEIN, HC | 1 |
BLENCOWE, W; GRUNBERG, E | 1 |
HAAPANEN, J; LEVY, D; MIDDLEBROOK, G; RUSSELL, WF | 1 |
MANDEL, W | 2 |
KOGUCHI, H | 1 |
CLOTTEN, R; HEILMEYER, L; KOHN, R | 1 |
REDLEAF, PD | 1 |
MENNE, WR; MODDE, H; SCHMIDT, B | 1 |
De Broucker, T; Martinez-Almoyna, L; Steichen, O | 1 |
Alexopoulou, A; Antoniou, C; Archimandritis, A; Katsambas, A; Katsaounis, P; Kilidireas, K; Koskinas, J; Papageorgiou, C; Soultati, A | 1 |
Charvátová, J; Gladziszová, M; Klimeš, J; Kovaříková, P; Pasáková, I; Stariat, J | 1 |
Arsalan, R; Sabzwari, S | 1 |
Granich, R; Harries, AD; Lawn, SD; Suthar, AB | 1 |
Chini, EN; Li, F; Liu, K; Lu, J; Ma, X; Tarrago, MG; Wang, P | 1 |
Elistratova, NA; Mozhokina, GN | 1 |
Patel, S; Roy, S; Weaver, MD | 1 |
Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L | 1 |
Muntean, PE | 1 |
Brewer, CT; Chen, T; Kodali, K; Peng, J; Shaw, TI; Wu, J | 1 |
Baumann, B; Campbell, JR; Chiang, LY; Cook, VJ; Djurdjev, O; Johnston, JC; Kumar, D; Levin, A; Morshed, M; Romanowski, K; Sekirov, I | 1 |
3 review(s) available for isoniazid and vitamin b 6
Article | Year |
---|---|
[ISONIAZID AND VITAMIN B6].
Topics: Carboxy-Lyases; Isoniazid; Liver; Metabolism; Neuritis; Pyridoxine; Research; Transaminases; Tryptophan; Vitamin B 6 | 1964 |
THE VITAMIN B6--HYDRAZIDE RELATIONSHIP.
Topics: Humans; Isoniazid; Metabolism; Pharmacology; Pyridoxine; Vitamin B 6 | 1964 |
Benefits of combined preventive therapy with co-trimoxazole and isoniazid in adults living with HIV: time to consider a fixed-dose, single tablet coformulation.
Topics: Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Coinfection; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Isoniazid; Male; Mycobacterium tuberculosis; Tablets; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Pulmonary; Vitamin B 6 | 2015 |
1 trial(s) available for isoniazid and vitamin b 6
Article | Year |
---|---|
Infection fighters. Maintenance therapy for TB works.
Topics: AIDS-Related Opportunistic Infections; Antitubercular Agents; Female; Humans; Isoniazid; Male; Placebos; Tuberculosis; Vitamin B 6 | 2001 |
63 other study(ies) available for isoniazid and vitamin b 6
Article | Year |
---|---|
Competitive action of isonicotinic acid hydrazide and vitamin B6 in the formation of indole by E. coli.
Topics: Biochemical Phenomena; Escherichia coli; Indoles; Isoniazid; Niacin; Nicotinic Acids; Vitamin B 6 | 1952 |
[Effect of vitamin B6 on convulsive action of isonicotinic acid hydrazide in rats].
Topics: Animals; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Rats; Vitamin B 6 | 1952 |
Competitive action of isonicotinic acid hydrazide and pyridoxal in the amino acid decarboxylation of Escherichia coli.
Topics: Amino Acids; Biochemical Phenomena; Decarboxylation; Escherichia coli; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pyridoxal; Vitamin B 6 | 1953 |
Relationship of pyridoxine and its derivatives to the mechanism of action of isoniazid.
Topics: Bacteria; Isoniazid; Pyridoxine; Vitamin B 6 | 1953 |
Effect of isoniazid on vitamin B6 metabolism; its possible significance in producing isoniazid neuritis.
Topics: Humans; Isomerism; Isoniazid; Neuritis; Niacin; Nicotinic Acids; Vitamin B 6 | 1954 |
Effect of pyridoxine on the action of isoniazid.
Topics: Isoniazid; Niacin; Nicotinic Acids; Pyridoxine; Vitamin B 6 | 1954 |
VITAMIN B6 and neuritis produced by isoniazid.
Topics: Humans; Isoniazid; Neuritis; Niacin; Nicotinic Acids; Vitamin B 6 | 1954 |
Effects of isoniazid on pyridoxine metabolism.
Topics: Biochemical Phenomena; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pyridoxine; Retina; Vitamin B 6 | 1954 |
[Comparative studies of the effect of pyridoxine, pyridoxal-5' -phosphate and pyridoxalisonicotinyl-hydrazone on experimental isoniazid-neuritis in rats].
Topics: Animals; Coenzymes; Hydrazones; Isoniazid; Neuritis; Niacin; Nicotinic Acids; Phosphates; Pyridoxal Phosphate; Pyridoxine; Rats; Vitamin B 6 | 1955 |
Isoniazid in vitamin B6-deficient rats.
Topics: Animals; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Rats; Vitamin B 6; Vitamin B 6 Deficiency | 1955 |
The effect of isoniazid therapy on pyridoxine metabolism in children.
Topics: Biochemical Phenomena; Child; Humans; Infant; Isoniazid; Pyridoxine; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1957 |
Effect of pyridoxal on uptake of C14-activity from labeled isoniazid by Mycobacterium tuberculosis.
Topics: Isoniazid; Mycobacterium tuberculosis; Pyridoxal; Vitamin B 6 | 1957 |
Quantitative studies on human urinary metabolites of tryptophan as affected by isoniazid and deoxypyridoxine.
Topics: Body Fluids; Humans; Isoniazid; Tryptophan; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1957 |
The delayed appearance of isoniazid antagonism by pyridoxine in vivo.
Topics: Hostility; Humans; Isoniazid; Pyridoxine; Vitamin B 6 | 1957 |
[Effect of phthivasid and isonicotinic acid hydrazide on growth of white rats in absence of vitamin B6 from the food ration].
Topics: Animals; Biological Phenomena; Food; Isoniazid; Physiological Phenomena; Rats; Vitamin B 6; Vitamin B 6 Deficiency | 1958 |
Massive-dose isoniazid with pyridoxine in chronic pulmonary tuberculosis.
Topics: Humans; Isoniazid; Pyridoxine; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1958 |
Use of pyridoxine hydrochloride to prevent isoniazid toxicity.
Topics: Humans; Isoniazid; Neuritis; Pyridoxine; Vitamin B 6 | 1958 |
[Large doses of isoniazid in therapy of pulmonary buberculosis].
Topics: Humans; Isoniazid; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1958 |
An evaluation of chemotherapy in pulmonary tuberculosis. I. High doses of isoniazid with PAS and pyridoxine.
Topics: Isoniazid; Pyridoxine; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1958 |
An evaluation of chemotherapy in pulmonary tuberculosis. II. Daily streptomycin plus high doses of isoniazid with PAS and pyridoxine.
Topics: Isoniazid; Pyridoxine; Streptomycin; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1958 |
A study of the effect of deoxypyridoxine or isoniazid upon mineral retention and liver enzyme activities of pyridoxine-deficient male rats.
Topics: Animals; Electrolytes; Enzymes; Isoniazid; Liver; Male; Minerals; Pyridoxine; Rats; Vitamin B 6; Vitamin B 6 Deficiency | 1958 |
[Vitamin B6 deficiency and urinary excretion of xanthurenic acid and other tryptophan metabolites in sick persons. II. Influence of isonicotinic acid hydrazide on vitamin B6 metabolism and vitamin B6 deficiency conditions in pregnant persons].
Topics: Biochemical Phenomena; Female; Humans; Isoniazid; Pregnancy; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Xanthurenates | 1958 |
[On a case of voluntary severe poisoning by rimifon (isonicotinic acid hydrazide). Treatment by vitamin B6].
Topics: Isoniazid; Suicide; Vitamin B 6 | 1960 |
[On the problem of the effect of therapeutic administration of phthivazide on vitamin B6 and nicotinic acid in patients with tuberculosis of the lungs].
Topics: Biochemical Phenomena; Humans; Isoniazid; Niacin; Nicotinic Acids; Tuberculosis; Vitamin B 6 | 1960 |
A study of the effect of deoxypyridoxine or isonicotinic acid hydrazide upon tissue potassium and sodium content of pyridoxine-deficient male rats.
Topics: Animals; Isoniazid; Male; Potassium; Pyridoxine; Rats; Sodium; Sodium, Dietary; Vitamin B 6; Vitamin B 6 Deficiency | 1960 |
[On the use of vitamin B6 in the field of INH therapy].
Topics: Coloring Agents; Isoniazid; Vitamin B 6 | 1960 |
Metabolism of C14-isoniazid in humans.
Topics: Aminosalicylic Acid; Isoniazid; Vitamin B 6 | 1961 |
[Studies on the amino acid in urine of tuberculous patients and on the variation due to administration of isoniazid and vitamin B6].
Topics: Amino Acids; Isoniazid; Tuberculosis; Vitamin B 6 | 1960 |
The lathyrogenic effect of isonicotinic acid hydrazide (INAH) on the chick embryo and its reversal by pyridoxal.
Topics: Aminopropionitrile; Animals; Bone and Bones; Chick Embryo; Collagen; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Lathyrism; Pyridoxal; Vitamin B 6 | 1961 |
[Attempted therapy of pulmonary tuberculosis with large doses of INH associated with pyridoxine].
Topics: Isoniazid; Pyridoxine; Tuberculosis, Pulmonary; Vitamin B 6 | 1960 |
Safe high dosage isoniazid therapy.
Topics: Isoniazid; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1959 |
[Anti-toxic action of glutamic acid, of vitamin B6 and of a combination of glutamic acid and vitamin B6 against the convulsant action and the lethal effects induced by isonicotinic acid hydrazide (INH) in the rat].
Topics: Animals; Convulsants; Glutamates; Glutamic Acid; Isoniazid; Rats; Seizures; Vitamin B 6 | 1959 |
[Isonicotinic acid hydrazide (INH) and the glutamic acid decarboxylase in the brain].
Topics: Brain; Glutamate Decarboxylase; Isoniazid; Lyases; Neurochemistry; Vitamin B 6 | 1959 |
[Critical observations on the use of vitamin B-6 within the scope of INH therapy on the basis of clinical and experimental animal observations].
Topics: Animals; Animals, Laboratory; Isoniazid; Vitamin B 6; Vitamins | 1960 |
[Changes in the effect of isonicotinic acid hydrazide on the thyroid gland following the administration of pyridoxine].
Topics: Isoniazid; Pyridoxine; Thyroid Gland; Viscera; Vitamin B 6 | 1962 |
Inhibition of catalase activity by isoniazid and the effect of vitamin B6.
Topics: Catalase; Copper; Humans; Isoniazid; Oxidation-Reduction; Pyridoxine; Vitamin B 6 | 1963 |
Effect of the administration of isoniazid and a dioet low in vitamin B6 on urinary excretion of oxalic acid.
Topics: Humans; Isoniazid; Oxalates; Oxalic Acid; Vitamin B 6; Vitamin B 6 Deficiency | 1963 |
[THE COMPARATIVE EFFECT OF INH, PHTHIVAZID AND METAZID ON VITAMIN B-6 EXCRETION IN TUBERCULOSIS PATIENTS].
Topics: Antitubercular Agents; Body Fluids; Humans; Isoniazid; Pharmacology; Pyridoxine; Tuberculosis; Urine; Vitamin B 6; Vitamins | 1963 |
[METABOLISM OF ISONICOTINIC ACID HYDRAZIDE. II. EFFECT OF VITAMIN B6 ON THE BLOOD LEVEL AND URINARY EXCRETION OF FREE ISONIAZID IN MAN].
Topics: Biomedical Research; Blood Chemical Analysis; Body Fluids; Humans; Isoniazid; Metabolism; Pyridoxine; Urine; Vitamin B 6 | 1963 |
[METABOLISM OF ISONICOTINIC ACID HYDRAZIDE. V. EFFECT OF VITAMIN B6 ON THE URINARY EXCRETION OF METABOLIC PRODUCTS OF ISONIAZID, IDENTIFIED AND SEPARATED BY A NEW PAPER CHROMATOGRAPHY METHOD].
Topics: Biomedical Research; Body Fluids; Chromatography; Chromatography, Paper; Humans; Isoniazid; Metabolism; Pyridoxine; Urine; Vitamin B 6 | 1963 |
[THE EUTROPHIC ACTION FAVORING ANTIBIOTIC TOLERANCE OF A VITAMIN COMPLEX: VITAMIN C AND VITAMIN B-6].
Topics: Anti-Bacterial Agents; Ascorbic Acid; Drug Tolerance; Immune Tolerance; Isoniazid; Metabolism; Pyridoxine; Toxicology; Tryptophan; Urine; Vitamin B 6; Vitamins; Xanthurenates | 1964 |
Effect of isonicotinic acid hydrazide on niacin and pyridoxine metabolism in rats.
Topics: Animals; Biochemical Phenomena; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pyridoxine; Rats; Vitamin B 6 | 1955 |
ISONIAZID and pyridoxine metabolism.
Topics: Biochemical Phenomena; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pyridoxine; Vitamin B 6 | 1955 |
Mechanism of competitive action of isonicotinic acid hydrazide and vitamin B6.
Topics: Isoniazid; Niacin; Nicotinic Acids; Vitamin B 6 | 1955 |
The influence of pyridoxine on the in vivo antituberculous activity of isoniazid.
Topics: Isoniazid; Mycobacterium tuberculosis; Niacin; Nicotinic Acids; Pyridoxine; Vitamin B 6 | 1955 |
Effect of pyridoxine on concentrations of active isoniazid in serum.
Topics: Isoniazid; Pyridoxine; Vitamin B 6 | 1960 |
Pyridoxine and the isoniazid-induced neuropathy.
Topics: Humans; Isoniazid; Peripheral Nervous System Diseases; Pyridoxine; Vitamin B 6 | 1959 |
Usefulness of a combined isoniazid, para-aminosalicylic acid and pyridoxine preparation.
Topics: Aminosalicylic Acid; Anti-Bacterial Agents; Isoniazid; Pyridoxine; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 6 | 1959 |
Effects of pyridoxine, gamma-aminobutyric acid and gamma-amino-beta-hydroxybutyric acid on the convulsions of dogs caused by toxopyrimidine or isonicotinic acid hydrazide.
Topics: Amino Acids; Animals; Antifibrinolytic Agents; Dogs; gamma-Aminobutyric Acid; Isoniazid; Pyridoxine; Pyrimidines; Seizures; Vitamin B 6 | 1962 |
[Reversible pyridoxine-sensitive symptomatic sideroachrestic anemia during isoniazid therapy of caseous lymph node tuberculosis with exudative pleurisy].
Topics: Anemia; Humans; Isoniazid; Lymph Nodes; Medical Records; Pleurisy; Pyridoxine; Tuberculosis; Tuberculosis, Lymph Node; Tuberculosis, Pulmonary; Vitamin B 6 | 1962 |
Pyridoxine-responsive anemia in a patient receiving isoniazid.
Topics: Anemia; Anemia, Sideroblastic; Genetic Diseases, X-Linked; Isoniazid; Pyridoxine; Vitamin B 6 | 1962 |
[On the problem of simultaneous application of the tuberculostatic INH and vitamin B6 in tuberculosis therapy with reference to some results of examination].
Topics: Humans; Isoniazid; Tuberculosis; Vitamin B 6 | 1962 |
[Isoniazid induced neuropathy: consider prevention].
Topics: Acetylation; Achilles Tendon; Adult; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Ethambutol; Female; Guinea; Hepatitis B, Chronic; HIV Infections; Humans; Hypesthesia; Inactivation, Metabolic; Isoniazid; Peripheral Nervous System Diseases; Reflex, Abnormal; Rifampin; Tuberculosis, Pulmonary; Vitamin B 6; Vitamin B 6 Deficiency | 2006 |
Acute bilateral phrenic neuropathy following treatment with adalimumab.
Topics: Acute Disease; Adalimumab; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Dyspnea; Female; Humans; Isoniazid; Jaundice; Mononeuropathies; Phrenic Nerve; Psoriasis; Respiratory Function Tests; Respiratory Insufficiency; Treatment Outcome; Vitamin B 6 | 2009 |
Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms.
Topics: Antitubercular Agents; Chromatography, High Pressure Liquid; Isoniazid; Vitamin B 6 | 2011 |
Isoniazid induced motor-dominant neuropathy.
Topics: Antitubercular Agents; Female; Humans; Isoniazid; Middle Aged; Muscle Weakness; Peripheral Nervous System Diseases; Reflex, Abnormal; Vitamin B 6; Vitamin B Complex | 2015 |
A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver.
Topics: Animals; Antitubercular Agents; Carnitine; Homeostasis; Isoniazid; Liver; Metabolomics; Mice; Oxidation-Reduction; Vitamin B 6 | 2016 |
Experimental Substantiation of Taurine Use in Prophylaxis of Isoniazid-Induced Neurotoxic Reactions.
Topics: Animals; Anticonvulsants; Antitubercular Agents; Drug Combinations; Drug Synergism; Female; Isoniazid; Male; Mice; Seizures; Survival Analysis; Taurine; Toxicity Tests, Acute; Vitamin B 6 | 2016 |
Miliary tuberculosis and herpes pharyngitis after a trip to a developing country: dangers of biologics.
Topics: Adalimumab; Aged, 80 and over; Anti-Bacterial Agents; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Biological Products; Developing Countries; Diagnosis, Differential; Herpes Simplex; Herpesvirus 1, Human; Humans; India; Isoniazid; Levofloxacin; Lung; Male; Opportunistic Infections; Pharyngitis; Pyrazinamide; Tomography, X-Ray Computed; Travel-Related Illness; Tuberculin Test; Tuberculosis, Miliary; Vitamin B 6 | 2018 |
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells; Hepatocytes; Humans; Hydrazines; Iron; Isoniazid; Liver; Mice, Inbred C57BL; Mice, Transgenic; Protoporphyrins; Pyridoxal; Rifampin; Vitamin B 6 | 2019 |
A Rare Case of a Tuberculosis Patient with Sarcoidosis.
Topics: Adult; Antitubercular Agents; Deprescriptions; Ethambutol; Female; Glucocorticoids; Humans; Isoniazid; Prednisolone; Pyrazinamide; Radiography, Thoracic; Rifampin; Romania; Sarcoidosis, Pulmonary; Tomography, X-Ray Computed; Tuberculosis, Pulmonary; Vitamin B 6; Vitamin B Complex | 2019 |
Toxicoproteomic Profiling of
Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Heme; Homocysteine; Iron-Sulfur Proteins; Isoniazid; Liver; Mice; Mice, Inbred C57BL; Niacinamide; Oxidative Stress; Proteome; Rifampin; Vitamin B 6 | 2020 |
Latent Tuberculosis Therapy Outcomes in Dialysis Patients: A Retrospective Cohort.
Topics: Aged; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cohort Studies; Exanthema; Female; Gastrointestinal Diseases; Humans; Isoniazid; Kidney Failure, Chronic; Latent Tuberculosis; Male; Mass Screening; Middle Aged; Pruritus; Renal Dialysis; Retrospective Studies; Rifabutin; Rifampin; Treatment Outcome; Vitamin B 6 | 2021 |