isoniazid and pyrimethamine

isoniazid has been researched along with pyrimethamine in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's16 (88.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Ali, MA; Choon, TS; Ismail, R; Kumar, RS; Wei, AC; Yoon, YK1
Danac, R; Mangalagiu, II1
Asís, SE; Buldain, GY; Muscia, GC1
Ali, MA; Choon, TS; Kanchithalaivan, S; Ponnuchamy, S; Ranjith Kumar, R1
Ashraf Ali, M; Choon, TS; Devi Bala, B; Muthusaravanan, S; Perumal, S1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Moreno-Viguri, E; Pérez-Silanes, S; Santivañez-Veliz, M; Torres, E1
Ashraf Ali, M; Bharkavi, C; Muthusubramanian, S; Osman, H; Perumal, S; Vivek Kumar, S2
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Baikova, IP; Giniyatullina, GV; Kataev, VE; Kazakova, OB; Lopatina, TV; Medvedeva, NI; Smirnova, IE1
Bera, S; Mondal, D1
Bandarizadeh, B; Dutz, W; Fakouhi, T; Jennings-Khodadad, E; Kohout, E; Post, C1

Reviews

2 review(s) available for isoniazid and pyrimethamine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Insights of synthetic analogues of anti-leprosy agents.
    Bioorganic & medicinal chemistry, 2019, 07-01, Volume: 27, Issue:13

    Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship

2019

Other Studies

16 other study(ies) available for isoniazid and pyrimethamine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as antimycobacterial agents.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Anti-Bacterial Agents; Cycloaddition Reaction; High-Throughput Screening Assays; Microbial Sensitivity Tests; Pyrrolidines

2013
Antimycobacterial activity of nitrogen heterocycles derivatives: bipyridine derivatives. Part III.
    European journal of medicinal chemistry, 2014, Mar-03, Volume: 74

    Topics: Antitubercular Agents; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Models, Molecular; Nitrogen; Pyridines

2014
Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.
    European journal of medicinal chemistry, 2014, Feb-12, Volume: 73

    Topics: Acridines; Animals; Antitubercular Agents; Cell Line; Cyclization; Drug Design; Drug Evaluation, Preclinical; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Quinolines

2014
Antimycobacterial evaluation of novel hybrid arylidene thiazolidine-2,4-diones.
    Bioorganic & medicinal chemistry letters, 2014, Feb-15, Volume: 24, Issue:4

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazolidinediones

2014
Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation.
    European journal of medicinal chemistry, 2014, Oct-06, Volume: 85

    Topics: Antitubercular Agents; Benzopyrans; Chemistry Techniques, Synthetic; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Naphthoquinones; Triazoles

2014
Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis.
    Bioorganic & medicinal chemistry letters, 2016, May-01, Volume: 26, Issue:9

    Topics: Animals; Antitubercular Agents; Cell Line; Cyclic N-Oxides; Drug Resistance, Multiple, Bacterial; Latent Tuberculosis; Mice; Mycobacterium tuberculosis; Quinoxalines; Tuberculosis, Multidrug-Resistant

2016
A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities.
    Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22

    Topics: Acetylcholinesterase; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholinesterase Inhibitors; Chromones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indenes; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Pyrrolidines; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Thiazoles

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE.
    Bioorganic & medicinal chemistry letters, 2017, 07-15, Volume: 27, Issue:14

    Topics: Acetylcholinesterase; Antitubercular Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; Enzyme Activation; Inhibitory Concentration 50; Microbial Sensitivity Tests; Microwaves; Molecular Conformation; Mycobacterium tuberculosis; Pyrroles; Stereoisomerism; Structure-Activity Relationship

2017
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Antitubercular Agents; Azepines; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Triterpenes

2018
Therapy and prophylaxis of Pneumocystis carinii pneumonia.
    National Cancer Institute monograph, 1976, Volume: 43

    Topics: Amidines; Aminosalicylic Acid; Animals; Complement Fixation Tests; Drug Therapy, Combination; Humans; Immunoglobulin G; Infant; Isoniazid; Pentamidine; Pneumonia, Pneumocystis; Protein-Energy Malnutrition; Pyrimethamine; Rabbits; Rats; Sulfadoxine; Sulfanilamides

1976