isoniazid and pyridoxal

isoniazid has been researched along with pyridoxal in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (37.50)	18.7374
1990's	31 (29.81)	18.2507
2000's	27 (25.96)	29.6817
2010's	5 (4.81)	24.3611
2020's	2 (1.92)	2.80

Authors

Authors	Studies
Borová, J; Fuchs, O; Necas, E; Neuwirt, J; Ponka, P	1
Hoy, T; Humphrys, J; Jacobs, A; Ponka, P; Williams, A	1
Borová, J; Fuchs, O; Neuwirt, J; Ponka, P	1
Raje, RR; Shah, PR	1
Matsuda, M; Murakami, Y	1
Callingham, BA; Levene, CI; Sharman, DF	1
Lacave, C; Lanéelle, G; Quémard, A	1
Vidrio, H	1
Brock, JH; Djeha, A	1
Nakornchai, S; Sookvanichsilp, N; Weerapradist, W	1
Campbell, RA; Gale, GR; Jones, MM; Litchenberg, WH; Singh, PK; Smith, AB	1
Eisenstein, RS; Garcia-Mayol, D; Munro, HN; Pettingell, W	1
Baker, E; Richardson, DR	1
Brittenham, GM	2
Chitambar, CR; Zivkovic-Gilgenbach, Z	1
Baker, E; Hefter, GT; May, PM; Richardson, DR; Webb, J	1
Baker, E; Richardson, D; Vitolo, LW; Webb, J	1
Bakkeren, DL; de Jeu-Jaspars, CM; Kroos, MJ; van Eijk, HG	1
Baker, E; Edward, JT; Ponka, P; Richardson, D; Schulman, HM	1
Bakkeren, DL; De Jeu-Jaspars, NM; Kroos, MJ; van Eijk, HG	1
Vitolo, ML; Webb, J	1
Grisham, JW; Sanders, GH; Tsao, MS	1
Clare, BW; Hefter, GT; Vitolo, ML; Webb, J	1
Baker, E; Ponka, P; Richardson, D; Vitolo, ML; Webb, J; Wilairat, P	1
Cheung, E; Sanders, EJ	1
Black, TN; Flynn, TJ; Friedman, L; Klein, NW	1
Andersson, LC; Ekblom, P; Landschulz, W	1
Brock, JH; Stevenson, J	1
Chitambar, CR; Zivkovic, Z	1
Bjelkenkrantz, K; Forsbeck, K; Nilsson, K	1
Finch, CA; Huebers, HA; Kim, BK	1
Ponka, P; Schulman, HM	1
Baker, E; Vitolo, ML; Webb, J	1
Ekblom, P; Landschulz, W	1
Bird, TA; Carrington, MJ; Levene, CI	1
Grady, RW; Ponka, P; Schulman, HM; Wilczynska, A	1
Ekblom, P; Landschulz, W; Thesleff, I	1
Avramovici-Grisaru, S; Hershko, C; Link, G; Sarel, S	1
Huang, AR; Ponka, P	1
Ponka, P; Schulman, HM; Wilczynska, A	1
Avramovici-Grisaru, S; Gelfand, L; Hershko, C; Link, G; Sarel, S	1
Finch, CA; Johnson, DK; Pippard, MJ	1
Cikrt, M; Necas, E; Neuwirt, J; Ponka, P	1
Ponka, P; Richardson, DR; Tran, EH	1
Chubb, FL; Edward, JT; Ponka, P; Richardson, DR	1
Ponka, P; Richardson, DR	3
Crowe, A; Morgan, EH	1
Brown, CS; Heath, TD; Mönkkönen, J; Thompson, TT	1
Bhattacharya, M; Chemtob, S; Hanna, N; Hardy, P; Lachapelle, P; Ponka, P; Varma, DR	1
Milnes, K; Richardson, DR	1
Richardson, DR	4
Connell, E; Hsu, C; Mescher, AL; Overton, B; Patel, C	1
Chubb, FL; Edward, JT; Sangster, J	1
Bláha, K; Cikrt, M; Nerudová, J; Ponka, HF	1
Boon, P; Chitambar, CR; Wereley, JP	1
Hermes-Lima, M; Nagy, E; Ponka, P; Schulman, HM	1
Andrews, M; Hermes-Lima, M; Ponka, P; Santos, NC; Schulman, HM; Yan, J	1
Bernhardt, PV; Richardson, DR	1
Becker, E; Richardson, DR	1
Hermes-Lima, M; Ponka, P; Schulman, HM	1
Chang, SJ	1
Becker, E; Mouralian, C; Ponka, P; Richardson, DR	1
Gao, J; Richardson, DR	1
Castilho, RF; Hermes-Lima, M; Meinicke, AR; Santos, NC	1
Andrade, RG; Gonçalves, MS; Hermes-Lima, M	1
Buss, JL; Neuzil, J; Ponka, P	2
Arduini, E; Buss, JL; Ponka, P	1
Adamcová, M; Gersl, V; Hrdina, R; Klimtová, I; Machácková, J; Pelouch, V; Ponka, P; Simůnek, T	1
Buss, JL; Gellert, N; Neuzil, J; Ponka, P; Weber, C	1
Breuer, W; Cabantchik, ZI; Hershko, C; Konijn, AM; Link, G; Ponka, P	1
Buss, JL; Ponka, P	1
Arduini, E; Buss, JL; Ponka, P; Shephard, KC	1
Buss, JL; Hermes-Lima, M; Ponka, P	1
Alonso, A; Gomes, CS; Hermes-Lima, M; Lopes, GK; Maurício, AQ; Oliveira, RG	1
ASANO, N; YONEDA, M	1
CANAL, N; GARATTINI, S	1
BOONE, IU; ROGERS, BS; STRANG, VG	1
LEVENE, CI	1
GONNARD, P; NGUYEN-PHILIPPON, C	1
CAMIER, M; GONNARD, P	1
Baliharová, V; Gersl, V; Kaiserová, H; Kvasnicková, E; Schröterová, L; Velík, J	1
Klime, J; Kovaríková, P; Mokrý, M; Vávrová, K	1
Adamcová, M; Gersl, V; Hrdina, R; Kaplanová, J; Klimtová, I; Mazurová, Y; Ponka, P; Simůnek, T; Sterba, M	1
Cabantchik, ZI; Hershko, CM; Konijn, AM; Link, GM	1
Klimes, J; Kovaríková, P; Mokrý, M; Vávrová, K	1
Bast, A; den Hartog, GJ; Kaiserová, H; Kvasnicková, E; Schröterová, L; Simůnek, T	1
Kalinowski, DS; Richardson, DR	1
Adamcova, M; Gersl, V; Kaiserova, H; Mazurova, Y; Ponka, P; Popelova, O; Potacova, A; Simunek, T; Sterba, M	1
Klimes, J; Kovaríková, P; Mrkvicková, Z	1
Kalinowski, DS; Klimes, J; Kovaríková, P; Lovejoy, DB; Richardson, DR; Stariat, J	1
Kovacevic, Z; Richardson, DR; Yu, Y	1
Cowley, PM; DeRuisseau, KC; DeRuisseau, LR; Doyle, RP; Fazen, CH; Park, YM	1
Kalinowski, DS; Menezes, SV; Merlot, AM; Pantarat, N; Richardson, DR; Sahni, S	1
Chen, YL; Hider, RC; Kong, X; Xie, Y	1
Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L	1
Chen, L; Rao, Z; Wei, Y; Wen, Y; Wu, X; Zhang, G	1
Chen, J; Lin, X; Lin, Z; Ru, J; Wen, M; Yang, S; Yao, C; Zhang, H; Zhuge, Q	1

Reviews

8 review(s) available for isoniazid and pyridoxal

Article	Year
Pyridoxal isonicotinoyl hydrazone: an effective iron-chelator after oral administration. Seminars in hematology, 1990, Volume: 27, Issue:2 Topics: Administration, Oral; Animals; Double-Blind Method; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Iron Chelating Agents; Isoniazid; Pyridoxal; Randomized Controlled Trials as Topic	1990
Pyridoxal isonicotinoyl hydrazone. Effective iron chelation after oral administration. Annals of the New York Academy of Sciences, 1990, Volume: 612 Topics: Administration, Oral; Animals; Drug Evaluation; Humans; Iron Chelating Agents; Isoniazid; Pyridoxal; Thalassemia	1990
Pyridoxal isonicotinoyl hydrazone (PIH): a promising new iron chelator. Birth defects original article series, 1988, Volume: 23, Issue:5B Topics: Chemical Phenomena; Chemistry; Humans; Iron Chelating Agents; Isoniazid; Pyridoxal	1988
Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. The Journal of laboratory and clinical medicine, 1998, Volume: 131, Issue:4 Topics: Animals; Iron Chelating Agents; Iron Overload; Isoniazid; Mice; Pyridoxal; Rats	1998
Analogues of pyridoxal isonicotinoyl hydrazone (PIH) as potential iron chelators for the treatment of neoplasia. Leukemia & lymphoma, 1998, Volume: 31, Issue:1-2 Topics: Animals; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Division; Humans; Iron Chelating Agents; Isoniazid; Membrane Proteins; Neoplasms; Pyridoxal	1998
Orally effective iron chelators for the treatment of iron overload disease: the case for a further look at pyridoxal isonicotinoyl hydrazone and its analogs. The Journal of laboratory and clinical medicine, 1998, Volume: 132, Issue:4 Topics: Administration, Oral; Animals; Deferiprone; Ferritins; Iron; Iron Chelating Agents; Iron Overload; Isoniazid; Pyridones; Pyridoxal; Rats; Treatment Outcome	1998
Pyridoxal isonicotinoyl hydrazone and its analogues. Advances in experimental medicine and biology, 2002, Volume: 509 Topics: Animals; Antioxidants; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Iron; Iron Chelating Agents; Iron Overload; Isoniazid; Molecular Structure; Pyridoxal	2002
Therapeutic potential of iron chelators in cancer therapy. Advances in experimental medicine and biology, 2002, Volume: 509 Topics: Animals; Antineoplastic Agents; Cell Cycle; Deferoxamine; Humans; Iron; Iron Chelating Agents; Isoniazid; Neoplasms; Pyridoxal; Thiosemicarbazones; Tumor Suppressor Protein p53	2002

Trials

3 trial(s) available for isoniazid and pyridoxal

Article	Year
Pyridoxal isonicotinoyl hydrazone: an effective iron-chelator after oral administration. Seminars in hematology, 1990, Volume: 27, Issue:2 Topics: Administration, Oral; Animals; Double-Blind Method; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Iron Chelating Agents; Isoniazid; Pyridoxal; Randomized Controlled Trials as Topic	1990
Pyridoxal isonicotinoyl hydrazone. Effective iron chelation after oral administration. Annals of the New York Academy of Sciences, 1990, Volume: 612 Topics: Administration, Oral; Animals; Drug Evaluation; Humans; Iron Chelating Agents; Isoniazid; Pyridoxal; Thalassemia	1990
Vitamin B6 antagonists alter the function and ultrastructure of mice endothelial cells. Journal of nutritional science and vitaminology, 2000, Volume: 46, Issue:4 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Endothelium, Vascular; Epoprostenol; Isoniazid; Mice; Mice, Inbred ICR; Microscopy, Electron; Pyridoxal; Pyridoxal Phosphate; Pyridoxine; Random Allocation; Vitamin B 6 Deficiency	2000

Other Studies

95 other study(ies) available for isoniazid and pyridoxal

Article	Year
A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents. Biochimica et biophysica acta, 1979, Aug-22, Volume: 586, Issue:2 Topics: Animals; Chelating Agents; Female; Hydrazones; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Mice; Mitochondria; Pyridoxal; Rabbits; Reticulocytes	1979
Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone. British journal of haematology, 1979, Volume: 43, Issue:3 Topics: Animals; Deferoxamine; Heme; Iron; Iron Chelating Agents; Isoniazid; Liver; Male; Pyridoxal; Pyridoxine; Rats; Spleen	1979
Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS letters, 1979, Jan-15, Volume: 97, Issue:2 Topics: Animals; Iron; Isoniazid; Kinetics; Pyridoxal; Pyridoxal Phosphate; Rabbits; Reticulocytes; Spectrophotometry	1979
Hydrazones of isoniazid for colorimetric analysis. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:2 Topics: Benzaldehydes; Colorimetry; Hydrazones; Isoniazid; Methods; Pyridoxal; Schiff Bases	1977
The effect of castrix (2-chloro-4- dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain. Biochemical pharmacology, 1976, Mar-15, Volume: 25, Issue:6 Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Isoniazid; Male; Mice; Penicillamine; Pyridoxal; Pyridoxal Phosphate; Pyridoxamine; Pyridoxine; Pyrimidines; Seizures; Semicarbazides	1976
Inhibition of chick embryo lysyl oxidase by various lathyrogens and the antagonistic effect of pyridoxal. International journal of experimental pathology, 1992, Volume: 73, Issue:5 Topics: Aminopropionitrile; Animals; Chick Embryo; Cross-Linking Reagents; Homocysteine; Isoniazid; Penicillamine; Protein-Lysine 6-Oxidase; Pyridoxal; Semicarbazides	1992
Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:6 Topics: Cell-Free System; Drug Resistance, Microbial; Fatty Acids, Nonesterified; Isoniazid; Mycobacterium; Mycolic Acids; NAD; Peroxidase; Pyridoxal; Pyridoxal Phosphate	1991
Interaction with pyridoxal as a possible mechanism of hydralazine hypotension. Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:1 Topics: Anesthesia; Animals; Blood Pressure; Cinnarizine; Dose-Response Relationship, Drug; Hydralazine; Injections, Intraperitoneal; Isoniazid; Male; Pyridoxal; Pyridoxine; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil	1990
Uptake and intracellular handling of iron from transferrin and iron chelates by mitogen stimulated mouse lymphocytes. Biochimica et biophysica acta, 1992, Jan-13, Volume: 1133, Issue:2 Topics: Animals; Cells, Cultured; Chelating Agents; Ferric Compounds; Intracellular Fluid; Iron; Iron Chelating Agents; Isoniazid; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Nitrilotriacetic Acid; Pyridoxal; Transferrin	1992
Toxicological study of pyridoxal isonicotinoyl hydrazone: acute and subchronic toxicity. Drug and chemical toxicology, 1991, Volume: 14, Issue:4 Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Weight; Chelating Agents; Female; Hematocrit; Injections, Intraperitoneal; Isoniazid; Kidney; Lethal Dose 50; Liver; Male; Mice; Pyridoxal; Rats	1991
Comparative iron mobilizing actions of deferoxamine, 1,2-dimethyl-3-hydroxypyrid-4-one, and pyridoxal isonicotinoyl hydrazone in iron hydroxamate-loaded mice. Research communications in chemical pathology and pharmacology, 1991, Volume: 73, Issue:3 Topics: Animals; Deferiprone; Deferoxamine; Hydroxamic Acids; Iron; Isoniazid; Male; Mice; Mice, Inbred Strains; Pyridones; Pyridoxal; Tissue Distribution	1991
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proceedings of the National Academy of Sciences of the United States of America, 1991, Feb-01, Volume: 88, Issue:3 Topics: Animals; Cell Line; Deferoxamine; Enzyme Induction; Ferritins; Fibroblasts; Heme; Heme Oxygenase (Decyclizing); Iron; Isoniazid; Kinetics; Pyridoxal; Rats	1991
The release of iron and transferrin from the human melanoma cell. Biochimica et biophysica acta, 1991, Feb-19, Volume: 1091, Issue:3 Topics: Antigens, Neoplasm; Cell Line; Deferoxamine; Humans; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Pyridoxal; Transferrin	1991
Influence of cellular iron status on the release of soluble transferrin receptor from human promyelocytic leukemic HL60 cells. The Journal of laboratory and clinical medicine, 1990, Volume: 116, Issue:3 Topics: Cell Membrane; Chromatography, Gel; Humans; Iron; Isoniazid; Leukemia, Promyelocytic, Acute; Ligands; Pyridoxal; Receptors, Transferrin; Solubility; Tumor Cells, Cultured	1990
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II) and zinc(II). Biology of metals, 1989, Volume: 2, Issue:3 Topics: Calcium; Chelation Therapy; Chemical Phenomena; Chemistry; Humans; Iron Chelating Agents; Isoniazid; Ligands; Magnesium; Pyridoxal; Zinc	1989
Pyridoxal isonicotinoyl hydrazone and analogues. Study of their stability in acidic, neutral and basic aqueous solutions by ultraviolet-visible spectrophotometry. Biology of metals, 1989, Volume: 2, Issue:2 Topics: Drug Stability; Hydrazones; Hydrogen-Ion Concentration; Hydrolysis; Iron Chelating Agents; Isoniazid; Pyridoxal; Solutions; Spectrophotometry; Spectrophotometry, Ultraviolet	1989
Release of iron from endosomes is an early step in the transferrin cycle. The International journal of biochemistry, 1987, Volume: 19, Issue:2 Topics: Adenosine Triphosphate; Cell Fractionation; Cell Line; Centrifugation; Endocytosis; Endosomes; Humans; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Leukemia, Erythroblastic, Acute; Pyridoxal; Transferrin	1987
Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes. Biochimica et biophysica acta, 1988, Oct-13, Volume: 967, Issue:1 Topics: Animals; Hydrazones; Iron; Isoniazid; Liver; Macrophages; Mice; Pyridoxal; Rabbits; Reticulocytes	1988
Characteristics of iron release from isolated heavy and light endosomes. The International journal of biochemistry, 1988, Volume: 20, Issue:8 Topics: Endocytosis; Ethylmaleimide; Humans; Iron; Iron Chelating Agents; Isoniazid; Lactates; Phenanthrolines; Proteins; Pyridoxal; Transferrin; Tumor Cells, Cultured; Uncoupling Agents	1988
Regulation of growth of cultured hepatic epithelial cells by transferrin. Experimental cell research, 1987, Volume: 171, Issue:1 Topics: Animals; Blood; Cell Division; Cell Line; Chelating Agents; Culture Media; Cycloheximide; DNA; Epidermal Growth Factor; Epithelial Cells; Epithelium; Insulin; Interphase; Isoniazid; Liver; Pyridoxal; Rats; Transferrin	1987
Chemical studies of pyridoxal isonicotinoyl hydrazone relevant to its clinical evaluation. Birth defects original article series, 1988, Volume: 23, Issue:5B Topics: Chemical Phenomena; Chemistry; Ferritins; Iron; Iron Chelating Agents; Isoniazid; Pyridoxal	1988
Effect of pyridoxal isonicotinoyl hydrazone and analogs on iron metabolism in hepatocytes and macrophages in culture. Birth defects original article series, 1988, Volume: 23, Issue:5B Topics: Animals; Cells, Cultured; Iron; Iron Chelating Agents; Isoniazid; Liver; Macrophages; Pyridoxal; Rats; Transferrin	1988
Transferrin and iron requirements of embryonic mesoderm cells cultured in hydrated collagen matrices. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1988, Volume: 24, Issue:6 Topics: Actins; Animals; Antibodies; Cell Aggregation; Cell Division; Cells, Cultured; Chick Embryo; Collagen; Fibroblasts; Iron; Iron Chelating Agents; Isoniazid; Mesoderm; Microscopy, Electron; Muscles; Pyridoxal; Transferrin	1988
Methionine and iron as growth factors for rat embryos cultured in canine serum. The Journal of experimental zoology, 1987, Volume: 244, Issue:2 Topics: Animals; Blood; Culture Media; Dogs; Growth Substances; Iron Chelating Agents; Isoniazid; Male; Methionine; Organ Culture Techniques; Pyridoxal; Rats; Transferrin	1987
A lipophilic iron chelator induces an enhanced proliferation of human erythroleukaemia (HEL) cells. Scandinavian journal of haematology, 1986, Volume: 36, Issue:3 Topics: Cell Cycle; Cell Line; Chelating Agents; Humans; Iron; Iron Chelating Agents; Isoniazid; Leukemia, Erythroblastic, Acute; Pyridoxal; Transferrin	1986
Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator. Immunology letters, 1987, Volume: 15, Issue:1 Topics: Animals; Culture Media; Iron Chelating Agents; Isoniazid; Lymphocyte Activation; Lymphocytes; Mice; Pyridoxal; Transferrin	1987
Inhibition of hemoglobin production by transferrin-gallium. Blood, 1987, Volume: 69, Issue:1 Topics: Anemia, Hypochromic; Animals; Cell Division; Cell Line; Cytarabine; Dimethyl Sulfoxide; Erythropoiesis; Gallium; Hemoglobins; Iron; Isoniazid; Mice; Pyridoxal; Receptors, Transferrin; Transferrin	1987
Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: effects of suramin and a lipophilic iron chelator (PIH). Scandinavian journal of haematology, 1986, Volume: 37, Issue:5 Topics: Cell Cycle; Cell Division; Cell Line; DNA; Humans; Intracellular Membranes; Iron; Iron Chelating Agents; Isoniazid; Neoplasms; Pyridoxal; Receptors, Transferrin; Suramin; Transferrin	1986
Effectiveness of oral iron chelators assayed in the rat. American journal of hematology, 1987, Volume: 24, Issue:3 Topics: Administration, Oral; Animals; Deferoxamine; Female; Ferritins; Iron Chelating Agents; Isoniazid; Male; Pyridoxal; Rats; Rats, Inbred Strains	1987
Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis. Blood, 1985, Volume: 65, Issue:4 Topics: 2,2'-Dipyridyl; Animals; Erythrocytes; Glycine; Heme; Heptanoates; Iron; Isoniazid; Porphyrins; Protoporphyrins; Pyridoxal; Rabbits; Reticulocytes; Transferrin	1985
Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture. Biochemical pharmacology, 1985, Sep-01, Volume: 34, Issue:17 Topics: Animals; Cells, Cultured; Chelating Agents; Deferoxamine; Iron; Isoniazid; Liver; Male; Pyridoxal; Rats; Rats, Inbred Strains; Transferrin	1985
Iron delivery during proliferation and differentiation of kidney tubules. The Journal of biological chemistry, 1985, Dec-15, Volume: 260, Issue:29 Topics: Animals; Cell Differentiation; Cell Division; Female; Hemin; Iron; Isoniazid; Kidney Tubules; Mice; Molecular Weight; Organ Culture Techniques; Pregnancy; Protoporphyrins; Pyridoxal; Transferrin	1985
The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo. The Biochemical journal, 1984, Aug-01, Volume: 221, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Bone and Bones; Cartilage; Chick Embryo; Collagen; Cycloheximide; Hydroxyproline; Isoniazid; Liver; Protein-Lysine 6-Oxidase; Pyridoxal; Pyridoxal Phosphate	1984
The effect of various chelating agents on the mobilization of iron from reticulocytes in the presence and absence of pyridoxal isonicotinoyl hydrazone. Biochimica et biophysica acta, 1984, Dec-20, Volume: 802, Issue:3 Topics: 2,2'-Dipyridyl; Animals; Chelating Agents; Globins; Hydrogen-Ion Concentration; Iron; Isoniazid; Phenanthrolines; Pyridoxal; Rabbits; Reticulocytes; Spectrophotometry	1984
A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation. The Journal of cell biology, 1984, Volume: 98, Issue:2 Topics: Animals; Cell Differentiation; Cell Division; DNA Replication; Embryo, Mammalian; Female; Iron Chelating Agents; Isoniazid; Kidney; Kidney Tubules; Kinetics; Mice; Mice, Inbred Strains; Organ Culture Techniques; Pregnancy; Pyridoxal; Transferrin	1984
Syntheses of iron bis(pyridoxal isonicotinoylhydrazone)s and the in vivo iron-removal properties of some pyridoxal derivatives. Journal of medicinal chemistry, 1983, Volume: 26, Issue:2 Topics: Animals; Chelating Agents; Hydrogen-Ion Concentration; Iron; Isoniazid; Kinetics; Liver; Magnetic Resonance Spectroscopy; Pyridoxal; Rats; Spectrophotometry, Infrared; Spleen; Structure-Activity Relationship	1983
A study of the mechanism of action of pyridoxal isonicotinoyl hydrazone at the cellular level using reticulocytes loaded with non-heme 59Fe. Biochimica et biophysica acta, 1983, Jun-09, Volume: 757, Issue:3 Topics: Animals; Binding Sites; Chelating Agents; In Vitro Techniques; Iron; Isoniazid; Male; Microtubules; Mitochondria; Oxidation-Reduction; Pyridoxal; Rabbits; Reticulocytes	1983
Ferric pyridoxal isonicotinoyl hydrazone can provide iron for heme synthesis in reticulocytes. Biochimica et biophysica acta, 1982, Oct-08, Volume: 718, Issue:2 Topics: Animals; Ferric Compounds; Heme; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Pyridoxal; Rabbits; Reticulocytes; Transferrin	1982
Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal. The Journal of laboratory and clinical medicine, 1981, Volume: 98, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Female; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Pyridoxal; Rats	1981
A rapid assay for evaluation of iron-chelating agents in rats. Blood, 1981, Volume: 58, Issue:4 Topics: Animals; Bile; Deferoxamine; Female; Ferritins; Injections, Intravenous; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Liver; Male; Pyridoxal; Rats; Rats, Inbred Strains; Time Factors	1981
Biliary iron excretion in rats following pyridoxal isonicotinoyl hydrazone. British journal of haematology, 1980, Volume: 45, Issue:2 Topics: Animals; Bile; Bile Ducts; Chelating Agents; Feces; Female; Hot Temperature; Iron; Isoniazid; Pyridoxal; Rats	1980
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents. Blood, 1995, Dec-01, Volume: 86, Issue:11 Topics: Antineoplastic Agents; Biological Transport, Active; Cell Division; Deferoxamine; Gallium; Humans; Iron; Iron Chelating Agents; Isoniazid; Pyridoxal; Transferrin; Tumor Cells, Cultured	1995
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to mobilise iron from reticulocytes in vitro. Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:6 Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chromatography, Thin Layer; In Vitro Techniques; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Lipids; Pyridoxal; Rabbits; Reticulocytes	1994
The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. The Journal of laboratory and clinical medicine, 1994, Volume: 124, Issue:5 Topics: Deferoxamine; DNA; Humans; Iron; Iron Chelating Agents; Isoniazid; Neuroblastoma; Osmolar Concentration; Pyridoxal; Thymidine; Transferrin; Tumor Cells, Cultured	1994
Effects of chelators on iron uptake and release by the brain in the rat. Neurochemical research, 1994, Volume: 19, Issue:1 Topics: 2,2'-Dipyridyl; Aging; Animals; Biological Transport; Bone and Bones; Brain; Deferiprone; Deferoxamine; Female; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Kidney; Liver; Male; Pentetic Acid; Pyridones; Pyridoxal; Rats; Rats, Wistar	1994
Liposome-mediated delivery of gallium to macrophage-like cells in vitro: demonstration of a transferrin-independent route for intracellular delivery of metal ions. Pharmaceutical research, 1993, Volume: 10, Issue:8 Topics: Ammonium Chloride; Animals; Cell Line; Chlorocebus aethiops; Drug Compounding; Drug Delivery Systems; Endocytosis; Gallium; Hemin; Iron Chelating Agents; Isoniazid; Liposomes; Macrophages; Melanoma; Metals; Mice; Nitrilotriacetic Acid; Pyridoxal; Transferrin; Tumor Cells, Cultured	1993
Prevention of postasphyxia electroretinal dysfunction with a pyridoxal hydrazone. Free radical biology & medicine, 1997, Volume: 22, Issue:1-2 Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Deferoxamine; Disease Models, Animal; Electroretinography; Humans; Hydrogen Peroxide; Infant, Newborn; Iron Chelating Agents; Isoniazid; Malondialdehyde; Oxidative Stress; Peroxides; Pyridoxal; Retina; Swine; Vision Disorders	1997
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood, 1997, Apr-15, Volume: 89, Issue:8 Topics: Antineoplastic Agents; Apoptosis; Benzaldehydes; Cell Cycle; Cell Division; Deferoxamine; DNA Fragmentation; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Ferritins; Growth Inhibitors; HL-60 Cells; Humans; Hydrazones; Iron; Iron Chelating Agents; Isoniazid; Ligands; Molecular Structure; Naphthols; Neoplasm Proteins; Neoplasms; Pyridoxal; Structure-Activity Relationship; Transferrin; Tumor Cells, Cultured	1997
Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process. Biochimica et biophysica acta, 1997, May-16, Volume: 1320, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Membrane; CHO Cells; Cricetinae; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Pyridoxal; Temperature; Tumor Cells, Cultured	1997
Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:9 Topics: Antineoplastic Agents; Copper; Ferric Compounds; Gallium; Humans; Iron Chelating Agents; Isoniazid; Pyridoxal	1997
Transferrin is necessary and sufficient for the neural effect on growth in amphibian limb regeneration blastemas. Development, growth & differentiation, 1997, Volume: 39, Issue:6 Topics: Ambystoma; Animals; Antibodies; Brain; Cell Division; Cell Extracts; Extremities; Iron; Iron Chelating Agents; Isoniazid; Liver; Nerve Tissue Proteins; Organ Culture Techniques; Peripheral Nerves; Pyridoxal; Regeneration; RNA, Messenger; Thymidine; Transferrin	1997
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to mobilize iron from reticulocytes in vitro: reappraisal of reported partition coefficients. Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:12 Topics: Iron; Iron Chelating Agents; Isoniazid; Models, Chemical; Pyridoxal; Reticulocytes	1997
Biliary iron excretion in rats following treatment with analogs of pyridoxal isonicotinoyl hydrazone. Blood, 1998, Jun-01, Volume: 91, Issue:11 Topics: Animals; Bile; Female; Iron; Iron Chelating Agents; Isoniazid; Pyridoxal; Rats; Rats, Wistar	1998
Evaluation of transferrin and gallium-pyridoxal isonicotinoyl hydrazone as potential therapeutic agents to overcome lymphoid leukemic cell resistance to gallium nitrate. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:6 Topics: Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gallium; Humans; Isoniazid; Leukemia, Lymphoid; Pyridoxal; Transferrin; Tumor Cells, Cultured	1996
The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against OH-mediated strand breaks. Free radical biology & medicine, 1998, Nov-15, Volume: 25, Issue:8* Topics: Antioxidants; DNA Damage; Ferrous Compounds; Hydroxyl Radical; Hypoxanthine; Iron Chelating Agents; Isoniazid; Oxidation-Reduction; Plasmids; Pyridoxal; Xanthine Oxidase	1998
EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on OH formation by the Fenton reaction. Biochimica et biophysica acta, 1999, Feb-02, Volume: 1426, Issue:3* Topics: Cyclic N-Oxides; Deoxyribose; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxyl Radical; Iron; Isoniazid; Oxidation-Reduction; Pyridoxal; Spin Trapping	1999
Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 1999, Volume: 4, Issue:3 Topics: Antineoplastic Agents; Cell Division; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemistry; Humans; Iron; Iron Chelating Agents; Isoniazid; Models, Molecular; Neuroectodermal Tumors, Primitive, Peripheral; Pyridoxal; Structure-Activity Relationship; Temperature; Tumor Cells, Cultured	1999
Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs. The Journal of laboratory and clinical medicine, 1999, Volume: 134, Issue:5 Topics: Biological Transport, Active; Cell Cycle; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Design; GADD45 Proteins; Gene Expression; Humans; Hydrazones; Intracellular Signaling Peptides and Proteins; Iron; Iron Chelating Agents; Isoniazid; Leucine; Ligands; Proteins; Pyridoxal; RNA; Thymidine; Transferrin; Uridine	1999
The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate. Biochimica et biophysica acta, 2000, Oct-18, Volume: 1523, Issue:2-3 Topics: Ascorbic Acid; Chelating Agents; Deoxyribose; Dimethyl Sulfoxide; DNA Damage; Edetic Acid; Ferric Compounds; Free Radical Scavengers; Hydroxyl Radical; Isoniazid; Kinetics; Models, Chemical; Plasmids; Pyridoxal; Structure-Activity Relationship	2000
Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron. Biochimica et biophysica acta, 2001, May-31, Volume: 1536, Issue:2-3 Topics: Animals; Drug Design; Friedreich Ataxia; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Ligands; Mice; Mitochondria; Molecular Structure; Phenylhydrazines; Pyridoxal; Reticulocytes	2001
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression. Blood, 2001, Aug-01, Volume: 98, Issue:3 Topics: Antineoplastic Agents; Cell Cycle; Cyclins; Deferoxamine; Female; Genes, Retinoblastoma; Humans; Hydroxyurea; Iron; Iron Chelating Agents; Isoniazid; Pyridoxal; Structure-Activity Relationship; Tumor Cells, Cultured	2001
The iron chelator pyridoxal isonicotinoyl hydrazone inhibits mitochondrial lipid peroxidation induced by Fe(II)-citrate. European journal of pharmacology, 2001, Sep-28, Volume: 428, Issue:1 Topics: Animals; Antioxidants; Chelating Agents; Ferric Compounds; In Vitro Techniques; Indicators and Reagents; Iron; Iron Chelating Agents; Isoniazid; Lipid Peroxidation; Membrane Potentials; Mitochondria, Liver; Oxidation-Reduction; Oxygen Consumption; Pyridoxal; Rats; Thiobarbituric Acid Reactive Substances	2001
Pyridoxal isonicotinoyl hydrazone (PIH) prevents copper-mediated in vitro free radical formation. Molecular and cellular biochemistry, 2001, Volume: 228, Issue:1-2 Topics: Ascorbic Acid; Copper Sulfate; Deoxyribose; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; In Vitro Techniques; Iron Chelating Agents; Isoniazid; Kinetics; Oxidation-Reduction; Oxygen; Pyridoxal	2001
The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues. Biochemical Society transactions, 2002, Volume: 30, Issue:4 Topics: Ascorbic Acid; Cell Survival; Chelating Agents; Drug Design; Humans; Iron Chelating Agents; Isoniazid; Jurkat Cells; K562 Cells; Kinetics; Molecular Structure; Oxidation-Reduction; Oxidative Stress; Pyridoxal; Structure-Activity Relationship	2002
Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes. Biochemical pharmacology, 2002, Dec-15, Volume: 64, Issue:12 Topics: Animals; Biological Transport; Cell Membrane Permeability; In Vitro Techniques; Iron; Iron Chelating Agents; Isoniazid; Mice; Pyridoxal; Reticulocytes; Serum Albumin, Bovine; Structure-Activity Relationship	2002
Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits. Physiological research, 2002, Volume: 51, Issue:5 Topics: Animals; Cell Fractionation; Cytosol; Iron Chelating Agents; Iron Overload; Isoniazid; Male; Myocardium; Myofibrils; Pyridoxal; Rabbits; Troponin T	2002
Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties. Biochemical pharmacology, 2003, Jan-15, Volume: 65, Issue:2 Topics: Apoptosis; Ferric Compounds; Hematopoietic Stem Cells; Humans; Iron; Iron Chelating Agents; Isoniazid; Jurkat Cells; K562 Cells; Mitochondria; Pyridoxal; Reticulocytes	2003
Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells. Blood, 2003, May-15, Volume: 101, Issue:10 Topics: Animals; Animals, Newborn; Blood Transfusion; Cells, Cultured; Deferoxamine; Female; Ferritins; Heart; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Kinetics; Pyridoxal; Rats; Rats, Wistar	2003
Hydrolysis of pyridoxal isonicotinoyl hydrazone and its analogs. Biochimica et biophysica acta, 2003, Jan-20, Volume: 1619, Issue:2 Topics: Animals; Cations; Cell Survival; Cells, Cultured; Drug Design; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Inhibitory Concentration 50; Iron; Iron Chelating Agents; Isoniazid; Mice; Molecular Structure; Pyridoxal; Reticulocytes; Time Factors	2003
Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells. Biochemical pharmacology, 2003, Feb-01, Volume: 65, Issue:3 Topics: Antineoplastic Agents; Biological Transport; Cell Division; Humans; Iron; Iron Chelating Agents; Isoniazid; K562 Cells; Pyridoxal	2003
Pyridoxal isonicotinoyl hydrazone inhibits iron-induced ascorbate oxidation and ascorbyl radical formation. Biochimica et biophysica acta, 2003, Mar-17, Volume: 1620, Issue:1-3 Topics: Ascorbic Acid; Chelating Agents; Deoxyribose; Edetic Acid; Electron Spin Resonance Spectroscopy; Ferric Compounds; Free Radicals; Hydroxyl Radical; Isoniazid; Nitrilotriacetic Acid; Oxidation-Reduction; Oxidative Stress; Pyridoxal	2003
Competitive action of isonicotinic acid hydrazide and pyridoxal in the amino acid decarboxylation of Escherichia coli. Science (New York, N.Y.), 1953, Mar-13, Volume: 117, Issue:3037 Topics: Amino Acids; Biochemical Phenomena; Decarboxylation; Escherichia coli; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pyridoxal; Vitamin B 6	1953
Isonicotinyl-hydrazide, hepatic respiratory quotient and inhibition of some enzymatic systems with pyridoxal coenzyme. Arzneimittel-Forschung, 1957, Volume: 7, Issue:3 Topics: Anti-Bacterial Agents; Coenzymes; Enzymes; Isoniazid; Liver; Pyridoxal	1957
Effect of pyridoxal on uptake of C14-activity from labeled isoniazid by Mycobacterium tuberculosis. American review of tuberculosis, 1957, Volume: 76, Issue:4 Topics: Isoniazid; Mycobacterium tuberculosis; Pyridoxal; Vitamin B 6	1957
The lathyrogenic effect of isonicotinic acid hydrazide (INAH) on the chick embryo and its reversal by pyridoxal. The Journal of experimental medicine, 1961, Apr-01, Volume: 113 Topics: Aminopropionitrile; Animals; Bone and Bones; Chick Embryo; Collagen; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Lathyrism; Pyridoxal; Vitamin B 6	1961
[SPECTRAL STUDY OF THE BINDING OF PYRIDOXAL-5'-PHOSPHATE ISONICOTINOYLHYDRAZONE TO ASPARTIC-GLUTAMIC APO-TRANSAMINASE]. Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1964, Feb-10, Volume: 258 Topics: Aspartate Aminotransferases; Isoniazid; Isonicotinic Acids; Phosphates; Pyridoxal; Pyridoxal Phosphate; Research; Spectrum Analysis	1964
[STUDY ON THE STABILITY OF 5'-PHOSPHOPYRIDOXAL ISONICOTINOYLHYDRAZONE IN THE PRESENCE OF PYRIDOXAL ENZYMES]. Bulletin de la Societe de chimie biologique, 1964, May-05, Volume: 46 Topics: Aspartate Aminotransferases; Carboxy-Lyases; Chromatography; Glutamates; Isoniazid; Manometry; Pyridoxal; Pyridoxal Phosphate; Research	1964
Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs. Archives of biochemistry and biophysics, 2004, Jan-01, Volume: 421, Issue:1 Topics: Apoptosis; Arachidonic Acids; Buthionine Sulfoximine; Cell Survival; Dose-Response Relationship, Drug; Ferric Compounds; Ferrozine; Glutathione; Humans; Inhibitory Concentration 50; Iron Chelating Agents; Isoniazid; Jurkat Cells; K562 Cells; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Oxygen; Pyridoxal	2004
The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro. Physiological research, 2004, Volume: 53, Issue:6 Topics: Aldehydes; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Agents; Cells, Cultured; Chelating Agents; Cytochrome P-450 Enzyme System; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Hepatocytes; Hydrazones; Isoniazid; Male; Oxidoreductases; Pyridoxal; Rabbits	2004
Chromatographic methods for the separation of biocompatible iron chelators from their synthetic precursors and iron chelates. Journal of separation science, 2004, Volume: 27, Issue:17-18 Topics: Aldehydes; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydrazones; Iron Chelating Agents; Isoniazid; Pyridoxal	2004
Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits. Pharmacological research, 2005, Volume: 51, Issue:3 Topics: Animals; Cardiotonic Agents; Daunorubicin; Heart Ventricles; Isoniazid; Male; Myocardium; Pyridoxal; Rabbits	2005
Iron chelation therapy. Current hematology reports, 2005, Volume: 4, Issue:2 Topics: Administration, Oral; Benzoates; beta-Thalassemia; Chelation Therapy; Chemical and Drug Induced Liver Injury; Deferasirox; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; Infusions, Intravenous; Iron Chelating Agents; Iron Overload; Isoniazid; Pyridones; Pyridoxal; Survival; Triazoles	2005
HPLC study on stability of pyridoxal isonicotinoyl hydrazone. Journal of pharmaceutical and biomedical analysis, 2006, Jan-23, Volume: 40, Issue:1 Topics: Calibration; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Hydrazones; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Models, Chemical; Oxygen; Pyridoxal; Solvents; Temperature; Time Factors; Ultraviolet Rays	2006
Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin. British journal of pharmacology, 2006, Volume: 149, Issue:7 Topics: Aldehydes; Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deferoxamine; Doxorubicin; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrazones; Hydrogen Peroxide; Iron; Iron Chelating Agents; Iron Compounds; Isoniazid; Lipid Peroxidation; Lung Neoplasms; Oxidative Stress; Pyridoxal; Razoxane; Time Factors	2006
Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy. Chemical research in toxicology, 2007, Volume: 20, Issue:5 Topics: Chelation Therapy; Humans; Hydrazones; Iron Chelating Agents; Iron Overload; Isoniazid; Pyridines; Pyridoxal; Structure-Activity Relationship; Thiosemicarbazones; Toxicology	2007
Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity. Hemoglobin, 2008, Volume: 32, Issue:1-2 Topics: Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Daunorubicin; Heart Diseases; Iron Chelating Agents; Isoniazid; Pyridoxal; Rabbits	2008
Investigation of the stability of aromatic hydrazones in plasma and related biological material. Journal of pharmaceutical and biomedical analysis, 2008, Jun-09, Volume: 47, Issue:2 Topics: Aldehydes; Animals; Buffers; Cattle; Chromatography, High Pressure Liquid; Culture Media; Drug Stability; Half-Life; Hemofiltration; Hydrazones; Hydrogen-Ion Concentration; Iron Chelating Agents; Isoniazid; Molecular Structure; Phosphates; Pyridoxal; Rabbits; Serum Albumin, Bovine; Temperature	2008
HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Jan-15, Volume: 877, Issue:3 Topics: Analysis of Variance; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Drug Stability; Humans; Isoniazid; Naphthalenes; Pyridoxal; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Swine; Thiosemicarbazones	2009
Chelators to the rescue: different horses for different courses! Chemical research in toxicology, 2011, Mar-21, Volume: 24, Issue:3 Topics: Aldehydes; Animals; Deferoxamine; Humans; Hydrazones; Iron Chelating Agents; Iron Overload; Isoniazid; Myocardial Reperfusion Injury; Neoplasms; Pyridines; Pyridoxal; Rats; Reactive Oxygen Species; Thiosemicarbazones	2011
Aging-related changes in the iron status of skeletal muscle. Experimental gerontology, 2013, Volume: 48, Issue:11 Topics: Aging; Animals; Cation Transport Proteins; Ferritins; Gene Expression; Heme; Iron; Iron Chelating Agents; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Isoniazid; Male; Muscle Contraction; Muscle, Skeletal; Muscular Atrophy; Pyridoxal; Rats; Rats, Inbred BN; Rats, Inbred F344; Receptors, Transferrin; RNA, Messenger; Sarcopenia	2013
Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism. Molecular pharmacology, 2013, Volume: 84, Issue:6 Topics: Animals; Antineoplastic Agents; Binding Sites; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cell Line, Tumor; Cell Membrane; Chelating Agents; Coordination Complexes; Copper; Endocytosis; Female; Heterografts; Humans; Iron; Isoniazid; Mice; Mice, Inbred BALB C; Mice, Nude; Pyridoxal; Temperature; Thiosemicarbazones	2013
The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron. Journal of inorganic biochemistry, 2018, Volume: 180 Topics: Aldehydes; Ascorbic Acid; Edetic Acid; Electrochemical Techniques; Electrodes; Ferric Compounds; Ferrous Compounds; Hydrazones; Hydrogen-Ion Concentration; Iron Chelating Agents; Isoniazid; Kinetics; Oxidation-Reduction; Pyridoxal	2018
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 03-01, Volume: 168, Issue:1 Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells; Hepatocytes; Humans; Hydrazines; Iron; Isoniazid; Liver; Mice, Inbred C57BL; Mice, Transgenic; Protoporphyrins; Pyridoxal; Rifampin; Vitamin B 6	2019
Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury. Toxicology and applied pharmacology, 2020, 09-01, Volume: 402 Topics: Animals; Apoptosis; Behavior, Animal; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Fatty Liver; Gene Expression Regulation; Hepatocytes; Humans; Isoniazid; Male; Models, Molecular; Necrosis; Protein Conformation; Pyridoxal; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger	2020
Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice. BioMed research international, 2021, Volume: 2021 Topics: Animals; Apoptosis; Cell Death; Cerebral Hemorrhage; Ferric Compounds; Ferroptosis; Inflammation; Iron; Iron Chelating Agents; Isoniazid; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Neurons; Pyridoxal	2021