isoniazid has been researched along with nad in 92 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 48 (52.17) | 18.7374 |
1990's | 8 (8.70) | 18.2507 |
2000's | 21 (22.83) | 29.6817 |
2010's | 13 (14.13) | 24.3611 |
2020's | 2 (2.17) | 2.80 |
Authors | Studies |
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Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Bock, L; Schaper, KJ; Seydel, JK; Tono-oka, S; Wiencke, M | 1 |
Aber, VR; Jackett, PS; Mitchison, DA | 1 |
Davis, WB; Weber, MM | 1 |
Argoudelis, CJ | 1 |
Devi, BG; Gopinathan, KP; Ramakrishnan, T; Shaila, MS | 1 |
Lacave, C; Lanéelle, G; Quémard, A | 1 |
Coburn, J; Gill, DM | 1 |
Gill, DM; Tamir, A | 1 |
Bowman, BU; Merola, AJ; Ottolenghi, AC; Shoeb, HA | 1 |
Martin, SP; Mathur, PP; Shah, NS | 1 |
Bekierkunst, A | 2 |
Greengard, P; Quinn, GP; Reid, MB | 1 |
Shah, NS | 2 |
Ramakrishnan, T; Sriprakash, KS | 2 |
Bekierkunst, A; Bricker, A | 1 |
Ando, F; Toida, I; Yamamoto, S | 1 |
O'Barr, TP; Smith, MA | 1 |
Youatt, J | 1 |
Tham, SH; Youatt, J | 1 |
Bastomsky, CH; McKenzie, JM; Zakarija, M | 1 |
Devi, BG; Gopinathan, KP; Ramakrishnan, T | 1 |
Toida, I | 1 |
Protivinsky, R | 1 |
Martin, SP; Shah, NS | 1 |
Blake, RL; Blake, SL; Kun, E; Loh, HH | 1 |
Collins, P; Winder, F | 1 |
Bartmann, K; Coper, H; Jütte, R | 1 |
Iwainsky, H; Reutgen, H | 1 |
Eady, RR; Large, PJ | 1 |
Collins, P; Winder, FG | 1 |
Kutt, H; Verebely, K | 1 |
Bernard, S; Le Cam, M; Madec, Y | 1 |
Turner, JM; Willetts, AJ | 1 |
Heard, JT; Tritz, GJ | 1 |
Davis, WB | 1 |
Kreisberg, RA; Wood, BC | 1 |
Herman, RP; Weber, MM | 1 |
Bittman, R; Blanchard, JS; Dessen, A; Jacobs, WR; Quémard, A; Sacchettini, JC; Vilcheze, C | 1 |
Blanchard, JS; Dessen, A; Jacobs, WR; Quémard, A; Sacchettini, JC | 1 |
Barton, DH; Grant, GA; Jacobs, WR; Rozwarski, DA; Sacchettini, JC | 1 |
Bittman, R; Jacobs, WR; Marcinkeviciene, JA; Miesel, L; Weisbrod, TR | 1 |
Basso, LA; Blanchard, JS; Jacobs, WR; Musser, JM; Zheng, R | 1 |
Amé, JC; Coyle, D; Jacobson, MK; Klis, M; Kornet, J; Slama, JT; Wall, KA | 1 |
Jacobs, WR; Miesel, L; Rozwarski, DA; Sacchettini, JC | 1 |
Bernadou, J; Meunier, B; Nguyen, M | 1 |
Alber, F; Carloni, P; Lamba, D; Pantano, S | 1 |
Bernadou, J; Claparols, C; Meunier, B; Nguyen, M | 1 |
Bernadou, J; Broussy, S; Meunier, B; Nguyen, M; Quémard, A | 1 |
Bernadou, J; Broussy, S; Coppel, Y; Meunier, B; Nguyen, M | 1 |
PATIALA, J | 1 |
CIOTTI, MM; COLOWICK, SP; KAPLAN, NO; ZATMAN, LJ | 1 |
SEKI, S | 1 |
TOIDA, I; YAMAMOTO, S | 1 |
EVANS, DA; WHITE, TA | 1 |
MAAYAN, ML | 1 |
BRUNNEMANN, A; COPER, H | 1 |
GOPINATHAN, KP; SIRSI, M; VAIDYANATHAN, CS | 1 |
Kim, E; Kim, EJ; Kim, YM; Koo, JH; Lee, HI; Ro, YT | 1 |
Rawat, R; Tonge, PJ; Whitty, A | 1 |
Basso, LA; Dietze, R; Moreira, IS; Oliveira, JS; Palaci, M; Santos, DS; Sousa, EH | 1 |
Carpena, X; Deemagarn, T; Donald, LJ; Duckworth, HW; Fita, I; Loewen, PC; Singh, R; Wiseman, B | 1 |
Alland, D; Chen, B; Hazbón, MH; Jacobs, WR; Kremer, L; Sacchettini, JC; Vilchèze, C; Wang, F; Weisbrod, TR | 1 |
Bernadou, J; Bernardes-Génisson, V; Broussy, S; Gornitzka, H; Meunier, B | 1 |
Bernadou, J; Bernardes-Génisson, V; Broussy, S; Coppel, Y; Meunier, B; Quémard, A | 1 |
Basso, LA; de Souza, ON; Santos, DS; Schroeder, EK | 1 |
Magliozzo, RS; Sacchettini, JC; Wang, F; Yu, H; Yu, S; Zhao, X | 1 |
Basso, LA; Canduri, F; de Azevedo, WF; de Souza, ON; Oliveira, JS; Pereira, JH; Rodrigues, NC; Santos, DS | 1 |
Basso, LA; de Sousa, EH; de Souza, ON; Moreira, IS; Oliveira, JS; Santos, DS | 1 |
Alland, D; Arai, M; Colangeli, R; Hazbón, MH; Jacobs, WR; Kremer, L; Sacchettini, JC; Vilchèze, C; Wang, F; Weisbrod, TR | 1 |
Deretic, V; Timmins, GS | 1 |
Basso, LA; de Azevedo, WF; Dias, MV; Fadel, V; Prado, AM; Santos, DS; Vasconcelos, IB | 1 |
Arnaud, P; Bernadou, J; Bernardes-Génisson, V; Delaine, T; Meunier, B; Stigliani, JL | 1 |
Choong, YS; Ibrahim, P; Sadikun, A; Scior, T; Wahab, HA | 1 |
Cade, CE; Dlouhy, AC; Ghiladi, RA; Medzihradszky, KF; Salas-Castillo, SP | 1 |
Chen, YD; Lu, XY; You, QD | 1 |
Carpena, X; Donald, LJ; Feliz, M; Fita, I; Loewen, PC; Pons, M; Wiseman, B | 1 |
Bernadou, J; Bernardes-Génisson, V; Constant, P; Delaine, T; Meunier, B; Quémard, A | 1 |
Belisle, JT; Boom, WH; Eisenach, KD; Johnson, JL; Joloba, ML; Lenaerts, AJ; Mahapatra, S; Woolhiser, LK | 1 |
Arias, CR; Chen, LC; Soo, VW; Yeh, CY; Yeh, HY | 1 |
Baltas, M; Bernadou, J; Bernardes-Génisson, V; Chollet, A; Delbot, A; Julien, S; Lherbet, C; Maveyraud, L; Mourey, L; Pratviel, G | 1 |
Chen, Y; Deng, H; Gu, L; Li, X; Mi, K; Wang, Q | 1 |
Kumar, V; Sobhia, ME | 1 |
Aljuhani, N; Khan, SR; Michail, K; Morgan, AG; Siraki, AG; Srivastava, N; Whittal, RM | 1 |
Deshmukh, S; Harinath, BC; Jena, L; Kumar, S; Waghmare, P | 1 |
Attalla, SM; Carter, WG; Christie, D; Elmorsy, E; Fikry, E; Kocon, A; Nwidu, LL; Turner, R; Warren, A | 1 |
Babu, R; Dadar, M; Doble, M; Hanna, LE; Hassan, S; Nancy Mary, MB; Sudhakar, V | 1 |
Abendroth, J; Alcaraz, M; Boudehen, YM; Cougoule, C; Edwards, TE; Kremer, L; Leon-Icaza, SA; Roquet-Banères, F | 1 |
Baquer, NZ; Hornbruch, A; McLean, P; Wolpert, L | 1 |
7 review(s) available for isoniazid and nad
Article | Year |
---|---|
A review of the action of isoniazid.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Membrane Permeability; Drug Resistance, Microbial; Isoniazid; Lipids; Mycobacterium tuberculosis; NAD; Nucleic Acids; Pigments, Biological | 1969 |
Chemotherapeutics with tuberculostatic action.
Topics: Aminosalicylic Acids; Antitubercular Agents; Catalase; Ethambutol; Ethionamide; Hemin; Humans; Hydrogen Peroxide; Isoniazid; Isonicotinic Acids; Metals; NAD; Pyrazinamide; Structure-Activity Relationship; Thiosemicarbazones | 1971 |
Drug and chemical-induced metabolic acidosis.
Topics: Acidosis; Adenosine Triphosphate; Age Factors; Animals; Biguanides; Carbon Monoxide; Catecholamines; Cyanides; Ethylene Glycols; Fructose; Humans; Isoniazid; Methanol; NAD; Salicylates | 1983 |
Mechanisms for isoniazid action and resistance.
Topics: Bacterial Proteins; Drug Resistance, Microbial; Isoniazid; Mutation; Mycobacterium smegmatis; Mycolic Acids; NAD; NADH Dehydrogenase; Oxidoreductases; Peroxidases | 1998 |
Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Design; Humans; Isoniazid; Kinetics; Mycobacterium tuberculosis; NAD; Oxidoreductases; Tuberculosis | 2006 |
Mechanisms of action of isoniazid.
Topics: Antitubercular Agents; Isoniazid; Mycobacterium tuberculosis; NAD | 2006 |
Recent progress in the identification and development of InhA direct inhibitors of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Enzyme Inhibitors; Isoniazid; Mycobacterium tuberculosis; NAD; Oxidoreductases; Pyrazoles; Triclosan | 2010 |
85 other study(ies) available for isoniazid and nad
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mode of action of isoniazide (INH). Short communication: isolation and identification of an analog of NAD from 3H-INH-treated bacterial cells.
Topics: Chromatography, Thin Layer; Isoniazid; Isonicotinic Acids; Mycobacterium tuberculosis; NAD | 1976 |
The relationship between nicotinamide adenine dinucleotide concentration and antibacterial activity of isoniazid in Mycobacterium tuberculosis.
Topics: Isoniazid; Mycobacterium tuberculosis; NAD; Time Factors | 1977 |
Specificity of isoniazid on growth inhibition and competition for an oxidized nicotinamide adenine dinucleotide regulatory site on the electron transport pathway in Mycobacterium phlei.
Topics: Adenosine Monophosphate; Culture Media; Drug Resistance, Microbial; Electron Transport; Hydrazines; Isoniazid; Mycobacterium; Mycobacterium phlei; Mycobacterium tuberculosis; NAD; NADH, NADPH Oxidoreductases | 1977 |
Mode of action of isoniazid on yeast.
Topics: Culture Media; Isoniazid; Lactobacillus; NAD; ortho-Aminobenzoates; Saccharomyces; Tryptophan | 1978 |
The purification and properties of peroxidase in Mycobacterium tuberculosis H37Rv and its possible role in the mechanism of action of isonicotinic acid hydrazide.
Topics: Catalase; Horseradish Peroxidase; Hydrogen-Ion Concentration; Iron; Isoniazid; Kinetics; Molecular Weight; Mycobacterium tuberculosis; NAD; Peroxidases; Species Specificity; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature | 1975 |
Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum.
Topics: Cell-Free System; Drug Resistance, Microbial; Fatty Acids, Nonesterified; Isoniazid; Mycobacterium; Mycolic Acids; NAD; Peroxidase; Pyridoxal; Pyridoxal Phosphate | 1991 |
ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase.
Topics: Adenosine Diphosphate Ribose; Animals; Brain Chemistry; Cattle; Cholera Toxin; Columbidae; Drug Synergism; Erythrocyte Membrane; GTP-Binding Proteins; Isoniazid; Membrane Proteins; Mice; NAD; NAD+ Nucleosidase; Pertussis Toxin; Swine; Virulence Factors, Bordetella | 1988 |
ADP-ribosylation by cholera toxin of membranes derived from brain modifies the interaction of adenylate cyclase with guanine nucleotides and NaF.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Brain; Cattle; Caudate Nucleus; Cell Membrane; Cholera Toxin; Coenzymes; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoniazid; Kinetics; NAD; NAD+ Nucleosidase; Sodium Fluoride | 1988 |
Enzymatic and nonenzymatic superoxide-generating reactions of isoniazid.
Topics: Catalysis; Electron Transport; Isoenzymes; Isoniazid; NAD; Nitroblue Tetrazolium; Nitroso Compounds; Oxidation-Reduction; Oxygen Consumption; Peroxidase; Peroxidases; Superoxides | 1985 |
Actions of isoniazid on NADH dehydrogenase activity of kidney of tuberculous guinea pigs.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Isoniazid; Kidney; NAD; Oxidoreductases; Tuberculosis | 1966 |
Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid.
Topics: In Vitro Techniques; Isoniazid; Mycobacterium tuberculosis; NAD; Nucleotidases | 1966 |
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine | 1966 |
Subcellular distribution of nicotinamide adenine dinucleotidase in the spleen of tuberculous guinea pigs and tuberculous guinea pigs treated with isoniazid.
Topics: Animals; Cell Nucleus; Centrifugation; Enzymes; Guinea Pigs; Isoniazid; Male; Microsomes; Mitochondria; NAD; Nucleotidases; Spleen; Tuberculosis | 1967 |
Comparative study of nicotinamide adenine dinucleotide nucleosidase from Mycobacterium tuberculosis H37Rv & pig brain: effect of isonicotinic acid hydrazide on the enzyme-inhibitor complex.
Topics: Animals; Brain; Enzymes; In Vitro Techniques; Isoniazid; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Swine | 1966 |
Effect of isoniazid on preservation of nicotinamide dinucleotide in animal cells.
Topics: Alcohol Oxidoreductases; Animals; Carcinoma, Ehrlich Tumor; Isoniazid; Liver; Lung; Mice; NAD; Nucleotidases; Spleen; Triaziquone; Tuberculosis | 1967 |
Studies on the mode of action of isoniazid on mycobacteria.
Topics: Aminosalicylic Acids; Drug Resistance, Microbial; Hot Temperature; Isoniazid; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Pyrazinamide; Streptomycin | 1967 |
Biochemical study on the host response to tuberculous infection. IV. Influences of isoniazid, streptomycin, nicotinamide, and cortisone.
Topics: Animals; Cortisone; Drug Resistance, Microbial; Isoniazid; Mice; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Niacinamide; Streptomycin; Tuberculosis | 1968 |
Comparative NADH-diaphorase content of isoniazid-resistant and isoniazid-susceptible Mycobacterium tuberculosis.
Topics: Dihydrolipoamide Dehydrogenase; Drug Resistance, Microbial; Electrophoresis; Isoniazid; Mycobacterium tuberculosis; NAD | 1969 |
An enzyme system of Mycobacterium tuberculosis that reacts specifically with isoniazid. I.
Topics: Cell-Free System; Coenzymes; Hydrogen-Ion Concentration; Isoniazid; Mycobacterium bovis; Mycobacterium tuberculosis; NAD; Pigments, Biological; Temperature | 1969 |
Nicotinamide HCl and thyroid radioiodine metabolism in mice: effects due to acid.
Topics: Animals; Diiodotyrosine; Female; Hydrochloric Acid; Hydrogen-Ion Concentration; Iodine; Iodine Isotopes; Isoniazid; Long-Acting Thyroid Stimulator; Mice; Monoiodotyrosine; NAD; Niacinamide; Nicotinic Acids; Pyridines; Sodium Hydroxide; Stimulation, Chemical; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1971 |
Isoniazid & nicotinamide adenine dinucleotide synthesis in Mycobacterium tuberculosis.
Topics: Cell-Free System; Depression, Chemical; Isoniazid; Metabolism; Mycobacterium tuberculosis; NAD | 1969 |
Enzymic interaction between isoniazid and nicotinamide-adenine dinucleotide.
Topics: Isoniazid; Mycobacterium; Mycobacterium tuberculosis; NAD | 1972 |
Effect of pyrazinamide on nicotinamide adenine dinucleotide glycohydrolase of tuberculous host.
Topics: Animals; Drug Resistance, Microbial; Isoniazid; Liver; Male; Mice; Mycobacterium Infections; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Niacinamide; Pyrazinamide | 1973 |
Isocitric dehydrogenase and nicotinamide adenine dinucleotidase in experimental tuberculosis: influence of isoniazid on metabolic damage.
Topics: Animals; Guinea Pigs; Isocitrate Dehydrogenase; Isoniazid; Kidney; Male; NAD; NADP; Nucleotidases; Tuberculosis | 1967 |
Further studies with isocitric dehydrogenase in experimental tuberculosis: influence of isoniazid on metabolic damage.
Topics: Animals; Azoles; Colorimetry; Guinea Pigs; Iproniazid; Isocitrate Dehydrogenase; Isoniazid; Kidney; Male; Mycobacterium tuberculosis; NAD; NADP; Nicotinic Acids; Phenazines; Spectrophotometry; Tuberculosis, Renal | 1967 |
The effect of nicotinamide and homologs on the activity of inducible enzymes and NAD content of the rat liver.
Topics: Animals; Brain; Dactinomycin; Enzyme Induction; Hydrocortisone; Hypophysectomy; Isoniazid; Kidney; Liver; Male; Muscles; Myocardium; NAD; Niacinamide; Nicotinic Acids; Nikethamide; Pyridines; Rats; Tryptophan Oxygenase; Tyrosine Transaminase | 1967 |
The effect of isoniazid on nicotinamide nucleotide levels in Mycobacterium bovis, strain BCG.
Topics: Isoniazid; Mycobacterium bovis; NAD; NADP | 1968 |
[NAD(P)-glycohydrolase in tuberculosis bacteria. A contribution to the mechanism of action INH].
Topics: Isoniazid; Isonicotinic Acids; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; NADP | 1967 |
[Studies on the endogenous metabolism of mycobacteria. 3. On the influence of isonicotinic acid hydrazide on the endogenous metabolism of mycobacteria].
Topics: Adenine Nucleotides; Chromatography; Cytosine Nucleotides; Depression, Chemical; Hexosephosphates; Isoniazid; Mycobacterium tuberculosis; NAD; Phosphates; Phosphorus Isotopes; Spectrophotometry | 1968 |
Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in growth on methylamine.
Topics: Amines; Amino Alcohols; Chloromercuribenzoates; Chromatography, Gel; Coloring Agents; Cytochromes; Electron Transport; Ferricyanides; Flavins; Histamine; Hydrogen-Ion Concentration; Isoniazid; Kinetics; NAD; NADP; Oxidoreductases; Oxygen; Phenazines; Pseudomonas; Quinacrine; Semicarbazides; Spectrophotometry; Succinates; Temperature; Vitamin K | 1968 |
The effect of isoniazid on nicotinamide nucleotide concentrations in tubercle bacilli. A correction and further observations.
Topics: Isoniazid; Mycobacterium; Mycobacterium bovis; Mycobacterium tuberculosis; NAD; NADP; Time Factors | 1969 |
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.
Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature | 1970 |
[Metabolic behavior of Mycobacterium tuberculosis strain H37 Ra under action of rifampicin, comparison with isoniazid].
Topics: Adenosine Triphosphate; Fructose-Bisphosphate Aldolase; Glycolysis; Isoniazid; Mycobacterium tuberculosis; NAD; NADP; Pyruvate Kinase; Rifampin; Transaminases | 1971 |
L-Threonine acetaldehyde-lyase in a strain of Bacillus subtilis.
Topics: Acetates; Aldehyde-Lyases; Bacillus subtilis; Carboxy-Lyases; Chromatography, Gel; Folic Acid; Glycine; Hydrazines; Hydrogen-Ion Concentration; Isoniazid; Kinetics; L-Serine Dehydratase; NAD; NADP; Phosphoric Acids; Pyridoxal Phosphate; Serine; Stereoisomerism; Threonine; Transferases | 1971 |
Isoniazid perturbation of the pyridine nucleotide cycle of Escherichia coli.
Topics: Escherichia coli; Isoniazid; Mutation; NAD; NADP; Niacin; Niacinamide; Nicotinamide Mononucleotide | 1982 |
Identification of a nicotinamide adenine dinucleotide glycohydrolase and an associated inhibitor in isoniazid-susceptible and -resistant Mycobacterium phlei.
Topics: Chromatography, Gel; Drug Resistance, Microbial; Hot Temperature; Isoniazid; Mycobacterium; Mycobacterium phlei; NAD; NAD+ Nucleosidase; Niacinamide | 1980 |
Site of action of isoniazid on the electron transport chain and its relationship to nicotinamide adenine dinucleotide regulation in Mycobacterium phlei.
Topics: Binding Sites; Cytochrome Reductases; Electron Transport; Isoniazid; Mycobacterium; Mycobacterium phlei; NAD; NADH Dehydrogenase; NADH, NADPH Oxidoreductases; Vitamin K | 1980 |
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
Topics: Acyl Coenzyme A; Bacterial Proteins; Binding Sites; Calorimetry; Cloning, Molecular; Gene Expression; Genes, Bacterial; Isoniazid; Kinetics; Mass Spectrometry; Models, Molecular; Mycobacterium tuberculosis; NAD; Oxidoreductases; Polymerase Chain Reaction; Protein Structure, Secondary; Recombinant Proteins; Substrate Specificity | 1995 |
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Topics: Bacterial Proteins; Binding Sites; Computer Graphics; Crystallization; Crystallography, X-Ray; Drug Resistance, Microbial; Hydrogen Bonding; Isoniazid; Models, Molecular; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Oxidoreductases; Protein Conformation; Protein Folding; Protein Structure, Secondary | 1995 |
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Binding Sites; Biotransformation; Crystallography, X-Ray; Drug Resistance, Microbial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acid Synthases; Isoniazid; Mass Spectrometry; Models, Molecular; Mutation; Mycobacterium tuberculosis; Mycolic Acids; NAD; Oxidoreductases | 1998 |
NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.
Topics: Amino Acid Sequence; Antitubercular Agents; Bacterial Proteins; Drug Resistance, Microbial; Genetic Complementation Test; Isoniazid; Malate Dehydrogenase; Microbial Sensitivity Tests; Models, Biological; Molecular Sequence Data; Mutation; Mycobacterium; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxidoreductases; Peroxidases; Phenotype; Quinones; Sequence Homology, Amino Acid | 1998 |
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Microbial; Humans; Isoniazid; Mutagenesis; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases; Tuberculosis | 1998 |
Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analogues.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Aplysia; Cell Membrane; Dogs; Humans; Isoniazid; Jurkat Cells; Kinetics; Membrane Glycoproteins; Mice; NAD; NAD+ Nucleosidase; Recombinant Proteins; Spleen; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
[The mechanism of action of isoniazid. A chemical model of activation].
Topics: Antitubercular Agents; Biotransformation; Catalase; Chromatography, High Pressure Liquid; Isoniazid; Mycobacterium tuberculosis; NAD; Peroxidase | 2001 |
NADH interactions with WT- and S94A-acyl carrier protein reductase from Mycobacterium tuberculosis: an ab initio study.
Topics: Acyl Carrier Protein; Antitubercular Agents; Bacterial Proteins; Drug Resistance, Bacterial; Isoniazid; Models, Chemical; Models, Molecular; Models, Theoretical; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases | 2002 |
A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts.
Topics: Antitubercular Agents; Bacterial Proteins; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Isoniazid; NAD; Organometallic Compounds; Oxidation-Reduction; Oxidoreductases | 2001 |
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biotransformation; Diphosphates; Isoniazid; Manganese; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Oxidoreductases | 2002 |
1H and 13C NMR characterization of hemiamidal isoniazid-NAD(H) adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis.
Topics: Bacterial Proteins; Chromatography, Liquid; Crystallography, X-Ray; Cyclization; Hydrogen-Ion Concentration; Indicators and Reagents; Isoniazid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Oxidoreductases | 2003 |
The amount of pyridine nucleotides (coenzymes I and II) in blood in experimental tuberculosis before and during isoniazid treatment.
Topics: Coenzymes; Isomerism; Isoniazid; NAD; Niacin; Nicotinic Acids; Nucleotides; Tuberculosis | 1954 |
The isolation and properties of the isonicotinic acid hydrazide analogue of diphosphopyridine nucleotide.
Topics: Coenzymes; Isomerism; Isoniazid; NAD; Niacin; Nicotinic Acids; Organic Chemicals | 1954 |
EFFECTS OF NICOTINAMIDE, ISONICOTINIC ACID HYDRAZIDE, AND 3-ACETYLPYRIDINE ON THE GROWTH AND NICOTINAMIDE ADENINE DINUCLEOTIDE CONTENT OF L CELLS.
Topics: Alcohol Oxidoreductases; Cell Division; Isoniazid; NAD; NADP; Niacin; Niacinamide; Pharmacology; Pyridines; Research; Research Design; Tissue Culture Techniques | 1963 |
[NICOTINAMIDE ADENINE DINUCLEOTIDE NUCLEOSIDASE IN MYCOBACTERIA. 1. ENZYME DISTRIBUTION].
Topics: Drug Resistance; Drug Resistance, Microbial; Isoniazid; Mycobacterium; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD | 1964 |
HUMAN ACETYLATION POLYMORPHISM.
Topics: 4-Aminobenzoic Acid; Acetylation; Acyltransferases; Adenine Nucleotides; Adenosine Triphosphate; Coenzyme A; Humans; Hydralazine; Isoniazid; Liver; Metabolism; NAD; Sulfamethazine; Sulfanilamide; Sulfanilamides; Transferases; Urine | 1964 |
NAD+-GLYCOHYDROLASE OF THYROID HOMOGENATES.
Topics: Animals; Biochemical Phenomena; Biochemistry; Diiodotyrosine; Isoniazid; Metabolism; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; NADP; Niacin; Niacinamide; Rats; Research; Spectrophotometry; Swine; Thyroid Gland | 1964 |
[COMPARATIVE STUDIES ON THE BIOSYNTHESIS OF NAD(P)-ANALOGS OF 3-ACETYLPYRIDINE, 4-ACETYLPYRIDINE, 6-AMINONICOTINAMIDE AND ISONICOTINIC ACID HYDRAZIDE].
Topics: 6-Aminonicotinamide; Brain; Isoniazid; NAD; Niacin; Niacinamide; Pyridines; Rats; Research | 1964 |
NICOTINAMIDE-ADENINE DINUCLEOTIDE-GLYCOHYDROLASE ACTIVITY IN EXPERIMENTAL TUBERCULOSIS.
Topics: Animals; Biochemical Phenomena; Biochemistry; Chloromercuribenzoates; Enzyme Inhibitors; Ethylmaleimide; Isoniazid; Liver; Lung; Metabolism; Mice; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Research; Tuberculosis | 1965 |
Purification, characterization, and physiological response of a catalase-peroxidase in Mycobacterium sp. strain JC1 DSM 3803 grown on methanol.
Topics: Amitrole; Antitubercular Agents; Bacterial Proteins; Chloroform; Dimerization; Enzyme Inhibitors; Enzyme Stability; Gene Expression; Hot Temperature; Hydrogen-Ion Concentration; Isoelectric Point; Isoniazid; Methanol; Molecular Weight; Mycobacterium; NAD; Nitroprusside; Oxidation-Reduction; Peroxidases; Protein Subunits; Substrate Specificity | 2003 |
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Bacterial; Enzyme Inhibitors; Isoniazid; Kinetics; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases; Thermodynamics | 2003 |
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
Topics: Drug Resistance, Bacterial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Iron; Isoniazid; Molecular Structure; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases | 2004 |
Catalase-peroxidases (KatG) exhibit NADH oxidase activity.
Topics: Bacterial Proteins; Binding Sites; Burkholderia pseudomallei; Catalase; Catalysis; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Escherichia coli Proteins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Ions; Isoniazid; Kinetics; Mass Spectrometry; Models, Chemical; Models, Molecular; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Oxygen; Peroxidase; Plasmids; Time Factors | 2004 |
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Topics: Antitubercular Agents; Blotting, Western; Culture Media; Drug Resistance, Bacterial; Ethionamide; Gene Expression Regulation, Bacterial; Isoniazid; Microbial Sensitivity Tests; Mutation; Mycobacterium; Mycobacterium bovis; Mycobacterium smegmatis; NAD; NADH Dehydrogenase; Phenotype; Plasmids; Quinone Reductases; Reverse Transcriptase Polymerase Chain Reaction; Transformation, Genetic | 2005 |
Studies on the 4-benzoylpyridine-3-carboxamide entity as a fragment model of the Isoniazid-NAD adduct.
Topics: Crystallography, X-Ray; Humans; Isoniazid; Molecular Conformation; Molecular Structure; NAD; Niacin; Pyridines; Tuberculosis | 2005 |
1H and 13C NMR characterization of pyridinium-type isoniazid-NAD adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Isoniazid; Magnetic Resonance Spectroscopy; Molecular Structure; Mycobacterium tuberculosis; NAD; Oxidoreductases; Pyridinium Compounds; Stereoisomerism | 2005 |
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities.
Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Binding Sites; Computer Simulation; Drug Resistance; Hydrogen Bonding; Isoniazid; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mycobacterium; NAD; Oxidoreductases; Protein Binding; Protein Conformation; Structure-Activity Relationship | 2005 |
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
Topics: Bacterial Proteins; Catalase; Crystallography, X-Ray; Hydrogen Peroxide; Isoniazid; Models, Molecular; Mutation; NAD; Oxidoreductases; Prodrugs; tert-Butylhydroperoxide | 2006 |
Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis.
Topics: Amino Acid Substitution; Antitubercular Agents; Bacterial Proteins; Binding Sites; Crystallography; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Isoniazid; Kinetics; Models, Molecular; Mycobacterium tuberculosis; NAD; Oxidoreductases; Protein Binding | 2006 |
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
Topics: Antitubercular Agents; Bacterial Proteins; Crystallography, X-Ray; Drug Resistance, Bacterial; Isoniazid; Mycobacterium tuberculosis; Mycolic Acids; NAD; Oxidoreductases; Point Mutation | 2006 |
Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
Topics: Bacterial Proteins; Crystallography, X-Ray; Drug Resistance, Bacterial; Isoniazid; Mutation, Missense; Mycobacterium tuberculosis; NAD; NADH, NADPH Oxidoreductases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation | 2007 |
Binding of the tautomeric forms of isoniazid-NAD adducts to the active site of the Mycobacterium tuberculosis enoyl-ACP reductase (InhA): a theoretical approach.
Topics: Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Isomerism; Isoniazid; Models, Molecular; Mycobacterium tuberculosis; NAD; Protein Binding; Protein Structure, Tertiary | 2008 |
Elucidating isoniazid resistance using molecular modeling.
Topics: Bacterial Proteins; Catalytic Domain; Drug Resistance, Bacterial; Genes, Bacterial; Informatics; Isoniazid; Ligands; Models, Molecular; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases; Protein Conformation; Thermodynamics; Water | 2009 |
Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
Topics: Antitubercular Agents; Bacterial Proteins; Catalase; Catalytic Domain; Drug Resistance, Bacterial; Humans; Isoniazid; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; Peroxidase; Protein Conformation; Tuberculosis, Multidrug-Resistant | 2010 |
Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
Topics: Antitubercular Agents; Bacterial Proteins; Binding Sites; Burkholderia pseudomallei; Catalase; Crystallography, X-Ray; Isoniazid; Kinetics; NAD; Peroxidases; Prodrugs | 2010 |
Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents.
Topics: Antitubercular Agents; Bacterial Proteins; Humans; Isoniazid; Mycobacterium tuberculosis; NAD; Oxidoreductases; Tuberculosis | 2010 |
A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Biotransformation; Catalase; Chromatography, Liquid; Drug Resistance, Bacterial; Female; Humans; Isoniazid; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Oxidoreductases; Tuberculosis, Pulmonary | 2012 |
Identifying co-targets to fight drug resistance based on a random walk model.
Topics: Algorithms; Anti-Bacterial Agents; Computational Biology; Drug Resistance; Ethionamide; Fatty Acids; Gene Expression Regulation, Bacterial; Humans; Isoniazid; Microarray Analysis; Models, Theoretical; Mycobacterium tuberculosis; NAD; Protein Interaction Maps; Search Engine; SOS Response, Genetics; Stochastic Processes | 2012 |
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
Topics: Bacterial Proteins; Biomimetics; Catalytic Domain; Isoniazid; Mycobacterium tuberculosis; NAD; Oxidoreductases; Protein Binding | 2015 |
Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis.
Topics: Acetylation; Amino Acid Sequence; Antitubercular Agents; Bacterial Proteins; Catalase; DNA-Directed RNA Polymerases; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Isoniazid; Metabolic Networks and Pathways; Microbial Sensitivity Tests; Molecular Sequence Annotation; Molecular Sequence Data; Mycobacterium smegmatis; NAD; Protein Subunits; Proteomics; Ribosomal Proteins; RNA, Messenger; Sirtuins; Transcription, Genetic | 2015 |
Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.
Topics: Amino Acid Substitution; Antitubercular Agents; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Diphosphates; Drug Resistance, Bacterial; Gene Expression; Hydrogen Bonding; Isoniazid; Kinetics; Ligands; Molecular Dynamics Simulation; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases; Protein Binding; Thermodynamics; Water | 2015 |
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
Topics: Antitubercular Agents; Humans; Hydrazines; Isoniazid; NAD; Neutrophil Activation; Neutrophils; Peroxidase; Primary Cell Culture; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 2016 |
Study of mechanism of interaction of truncated isoniazid-nicotinamide adenine dinucleotide adduct against multiple enzymes of Mycobacterium tuberculosis by a computational approach.
Topics: Antitubercular Agents; Bacterial Proteins; Humans; Isoniazid; Molecular Docking Simulation; Mycobacterium tuberculosis; NAD; Tuberculosis | 2015 |
Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics.
Topics: Adenosine Triphosphate; Antitubercular Agents; Drug Interactions; Electron Transport Complex I; Electron Transport Complex III; Energy Metabolism; Hep G2 Cells; Humans; Isoniazid; Lactic Acid; Membrane Potential, Mitochondrial; NAD; Pyrazinamide; Rifampin | 2017 |
Computational approach identifies protein off-targets for Isoniazid-NAD adduct: hypothesizing a possible drug resistance mechanism in
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance; Drug Resistance, Bacterial; Isoniazid; Mutation; Mycobacterium tuberculosis; NAD | 2020 |
Efficacy and Mode of Action of a Direct Inhibitor of
Topics: Antitubercular Agents; Bacterial Proteins; Catalase; Humans; Isoniazid; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Mycolic Acids; NAD; Prodrugs | 2022 |
Positional information and pattern regulation in hydra: enzyme profiles.
Topics: Alanine Transaminase; Animals; Brain; Carbon Dioxide; Glucose; Glucosephosphate Dehydrogenase; Glycolysis; Hydra; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Mammary Glands, Animal; NAD; NADP; Oligomycins | 1975 |