isoniazid and methyldopa

isoniazid has been researched along with methyldopa in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (67.39)	18.7374
1990's	1 (2.17)	18.2507
2000's	5 (10.87)	29.6817
2010's	9 (19.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Oldershausen v, HF	1
Atkinson, AR; Norris, KA; Smith, WG	1
Dybing, E; Mitchell, JR	1
Boitnott, JK; Maddrey, WC	2
Buffet, C; Chaput, JC; Etienne, P; Labayle, D; Lenoir, C	1
Rotermund, HM	1
Heissmeyer, HH	1
Lauterburg, BH; Mitchell, JR	1
Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS	1
Zimmerman, HJ	1
Dybing, E	1
Kumar, KL; Reuler, JB	1
Cush, JJ; Goldings, EA	1
Hirayama, C; Yamamoto, T	1
Oka, H; Yamada, H; Yoshiba, M; Yoshikawa, Y	1
Bien, E	1
Estes, D; Peltier, AP	1
Eldredge, NT; Jiller, JJ; van Robertson, WB	1
de Sèze, S; Dorfmann, H; Kahn, MF	1
Feltkamp, TE; ten Veen, JH	1
ten Veen, JH	1
Gault, MH; Hebert, MA; Singh, HP	1
DeSwarte, RD	1
Larizza, P	1
Salaspuro, M	1
Maddrey, WC	1
Parker, CW	1
Kawasaki, H; Murawaki, Y; Yamada, S; Yamamoto, T	1
ADICOFF, A; ALEXANDER, CS; DAVIS, RB	1
Markova, LN; Ostroumova, TV	1
BARRNETT, RJ; LENTZ, TL	1

Reviews

12 review(s) available for isoniazid and methyldopa

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Hepatitis-like liver disorders caused by infections, poisoning and drugs]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1 Topics: Alcoholism; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infections; Halothane; Hepatitis; Humans; Infectious Mononucleosis; Isoniazid; Liver Diseases; Methyldopa; Rickettsia Infections; Virus Diseases; Yellow Fever	1976
Drug-induced chronic liver disease. Gastroenterology, 1977, Volume: 72, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Halothane; Humans; Indoles; Isoniazid; Methyldopa; Oxyphenisatin Acetate; Phenothiazines	1977
[Drug-induced active hepatitis (author's transl)]. La Nouvelle presse medicale, 1979, Jun-02, Volume: 8, Issue:24 Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Indoles; Isoniazid; Male; Methyldopa; Oxyphenisatin Acetate; Prognosis	1979
Drug-induced chronic hepatitis and cirrhosis. Progress in liver diseases, 1979, Volume: 6 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Female; Halothane; Hepatitis; Humans; Isoniazid; Liver Cirrhosis; Male; Methyldopa; Necrosis; Oxyphenisatin Acetate	1979
Metabolic activation: biochemical basis for many drug-induced liver injuries. Progress in liver diseases, 1976, Volume: 5 Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes	1976
Drug-induced lupus: clinical spectrum and pathogenesis. The American journal of the medical sciences, 1985, Volume: 290, Issue:1 Topics: Acetylation; Adult; Aged; Antibodies, Antinuclear; Antibody Specificity; Autoimmune Diseases; Black People; Brain; Chlorpromazine; Female; Heart; Humans; Hydralazine; Isoniazid; Kidney; Liver; Lung; Lupus Erythematosus, Systemic; Male; Methyldopa; Muscles; Phenotype; Procainamide	1985
[Intermediate metabolites and liver toxicity]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Acetaminophen; Animals; Aspirin; Chlorpromazine; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Methyldopa; Rats	1985
[Prevention and therapy of severe toxic hepatitis]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Halothane; Humans; Isoniazid; Methyldopa; Perfusion; Plasma Exchange; Prognosis	1985
[Possibilities of liver damage by foreign substances]. Die Pharmazie, 1985, Volume: 40, Issue:11 Topics: Aminopyrine; Animals; Antimetabolites; Carcinogens; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Galactosamine; Halothane; Humans; Isoniazid; Membranes; Methyldopa; Nucleic Acids; Oxidation-Reduction; Pharmaceutical Preparations; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis	1985
Antinuclear antibodies. Pathobiology annual, 1972, Volume: 2 Topics: Animals; Antibodies, Antinuclear; Antibody Formation; Arthritis, Rheumatoid; Autoantigens; Cytotoxicity Tests, Immunologic; DNA; Fluorescent Antibody Technique; Humans; Hydralazine; Immune Adherence Reaction; Isoniazid; Lupus Erythematosus, Systemic; Methyldopa; Nephritis; Neutrophils; Nucleoproteins; Procainamide; Sjogren's Syndrome	1972
Drug-related acute and chronic hepatitis. Clinics in gastroenterology, 1980, Volume: 9, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Fever; Halothane; Humans; Isoniazid; Liver; Male; Methyldopa; Middle Aged; Necrosis; Oxyphenisatin Acetate; Phenytoin	1980

Other Studies

34 other study(ies) available for isoniazid and methyldopa

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Colorimetric enzymatic determination of serum total carbon dioxide, as applied to the Vickers Multichannel 300 discrete analyzer. Clinical chemistry, 1975, Volume: 21, Issue:8 Topics: Acetoacetates; Aminosalicylic Acids; Animals; Ascorbic Acid; Autoanalysis; Bilirubin; Carbon Dioxide; Carboxy-Lyases; Edible Grain; Humans; Hydrogen-Ion Concentration; Isoniazid; Levodopa; Malate Dehydrogenase; Methyldopa; Myocardium; Oxaloacetates; Phosphoenolpyruvate; Pyruvates; Sulfathiazoles; Swine	1975
The role of metabolic activation for drug-induced liver injuries. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyldopa	1977
[Drug-induced chronic aggressive hepatitis]. Medizinische Klinik, 1977, Dec-16, Volume: 72, Issue:50 Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Humans; Isoniazid; Methyldopa; Oxyphenisatin Acetate; Prognosis; Salicylates; Sulfonamides	1977
[Clinical aspects of chronic hepatitis. Diagnosis and differential diagnosis]. ZFA. Zeitschrift fur Allgemeinmedizin, 1978, Mar-10, Volume: 54, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Diagnosis, Differential; Female; Hepatitis; Humans; Isoniazid; Liver Cirrhosis; Male; Methyldopa; Oxyphenisatin Acetate	1978
Drug-induced liver injury. Hospital practice, 1978, Volume: 13, Issue:9 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Halothane; Humans; Isoniazid; Liver; Methyldopa; Mice	1978
Liver disease caused by medicinal agents. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptive Agents; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Halothane; Humans; Isoniazid; Jaundice; Liver; Liver Cirrhosis; Metabolism, Inborn Errors; Methotrexate; Methoxyflurane; Methyldopa; Necrosis; Novobiocin	1975
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Liver; Methyldopa; Necrosis	1976
Drug fever. The Western journal of medicine, 1986, Volume: 144, Issue:6 Topics: Allopurinol; Anti-Bacterial Agents; Body Temperature Regulation; Drug Hypersensitivity; Fever; Humans; Interleukin-1; Isoniazid; Methyldopa; Phenytoin; Procainamide; Quinidine	1986
Psychiatric side effects of nonpsychiatric drugs. Seminars in psychiatry, 1971, Volume: 3, Issue:4 Topics: Aminophylline; Analgesics; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; Antihypertensive Agents; Central Nervous System Stimulants; Chlordiazepoxide; Diazepam; Diuretics; Drug-Related Side Effects and Adverse Reactions; Furosemide; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Insulin; Isoniazid; Mental Disorders; Methyldopa; Phenobarbital; Prednisone	1971
The interaction of lupus-inducing drugs with deoxyribonucleic acid. Clinical immunology and immunopathology, 1974, Volume: 3, Issue:2 Topics: Adult; Animals; Cattle; Child; DNA; DNA, Single-Stranded; Hot Temperature; Humans; Hydralazine; Immunodiffusion; Isoniazid; Lupus Erythematosus, Systemic; Methyldopa; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optical Rotation; Oxazoles; Phenytoin; Procainamide; Propylthiouracil; Thymus Gland; Trimethadione; Viscosity	1974
[Iatrogenic lupus: current status of the question. I. Clinical study and main drugs responsible]. La Nouvelle presse medicale, 1972, Dec-02, Volume: 1, Issue:43 Topics: Antibodies, Antinuclear; Contraceptives, Oral; Diagnosis, Differential; Humans; Hydralazine; Iatrogenic Disease; Isoniazid; Lupus Erythematosus, Systemic; Methyldopa; Procainamide; Sulfonamides	1972
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA). Clinical and experimental immunology, 1972, Volume: 11, Issue:2 Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Antibody Formation; Chlorthalidone; Coombs Test; DNA; Female; Fluorescent Antibody Technique; Genetics; Hydralazine; Isoniazid; Lupus Erythematosus, Systemic; Male; Methyldopa; Mice; Mice, Inbred Strains; Procainamide; Sex Factors	1972
Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies. Clinical and experimental immunology, 1973, Volume: 15, Issue:3 Topics: Animals; Antibody Formation; Autoantibodies; Cell Membrane; Chlorthalidone; Fluorescent Antibody Technique; Hydralazine; Isoniazid; Liver; Lupus Erythematosus, Systemic; Lymphocytes; Methyldopa; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscle, Smooth; Muscles; Procainamide	1973
Effect of some drugs on clinical laboratory values as determined by the Technicon SMA 12-60. Clinical chemistry, 1972, Volume: 18, Issue:2 Topics: Acetaminophen; Alkaline Phosphatase; Aminosalicylic Acids; Ascorbic Acid; Aspartate Aminotransferases; Autoanalysis; Bilirubin; Blood Chemical Analysis; Blood Glucose; Chemical Phenomena; Chemistry; Cholesterol; Clinical Laboratory Techniques; Dihydroxyphenylalanine; Evaluation Studies as Topic; Humans; Isoniazid; L-Lactate Dehydrogenase; Mercaptopurine; Methyldopa; Pharmaceutical Preparations; Spectrophotometry; Sulfathiazoles; Uric Acid	1972
Drug allergy--problems and strategies. The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:3 Pt 1 Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Response Relationship, Immunologic; Drug Hypersensitivity; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Encephalomyelitis, Acute Disseminated; Exanthema; Humans; Hydralazine; Immunity, Cellular; Isoniazid; Kidney Diseases; Liver Diseases; Lupus Erythematosus, Systemic; Lymphoid Tissue; Methyldopa; Nephritis, Interstitial; Penicillins; Phenytoin; Procainamide; Respiratory Hypersensitivity; Vasculitis, Leukocytoclastic, Cutaneous	1984
[Introduction and general data on the subject of the pathology of drugs]. Minerva medica, 1984, Aug-25, Volume: 75, Issue:32-33 Topics: Agranulocytosis; Anemia, Hemolytic; Anemia, Megaloblastic; Anemia, Sideroblastic; Bleomycin; Bone Marrow Diseases; Busulfan; Humans; Hydantoins; Iatrogenic Disease; Isoniazid; Leukopenia; Methyldopa; Pulmonary Fibrosis; Sulfonamides	1984
[Drug-induced liver damage; new aspects on its mechanism]. Duodecim; laaketieteellinen aikakauskirja, 1980, Volume: 96, Issue:5 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Estrogens; Female; Halothane; Humans; Isoniazid; Liver; Methyldopa; Oxyphenisatin Acetate	1980
Hapten immunology and allergic reactions in humans. Arthritis and rheumatism, 1981, Volume: 24, Issue:8 Topics: Animals; Autoimmune Diseases; Carrier Proteins; Drug Hypersensitivity; Environmental Health; Haptens; HLA Antigens; Humans; Hydralazine; Immunization, Passive; Isoniazid; Lupus Erythematosus, Systemic; Macromolecular Substances; Methyldopa; Nitrobenzenes; Nucleic Acids; Penicillins; Procainamide	1981
[Toxic cirrhosis]. Nihon rinsho. Japanese journal of clinical medicine, 1994, Volume: 52, Issue:1 Topics: Carbon Tetrachloride Poisoning; Humans; Hypervitaminosis A; Isoniazid; Liver Cirrhosis; Methotrexate; Methyldopa	1994
Metabolic studies in carcinoid syndrome: observations on use of alpha-methyl DOPA, isonicotinic acid hydrazide and selective tryptophan deficiency. Metabolism: clinical and experimental, 1961, Volume: 10 Topics: Dihydroxyphenylalanine; Humans; Isoniazid; Malignant Carcinoid Syndrome; Methyldopa; Serotonin; Tryptophan	1961
[Effect of inhibitors of synthesis of dopamine and its antagonists on Hydra attenuata regeneration]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2000, Volume: 86, Issue:10 Topics: alpha-Methyltyrosine; Animals; Dopamine; Dopamine Antagonists; Haloperidol; Hydra; Methyldopa; Monoiodotyrosine; Regeneration; Spiperone	2000
THE ROLE OF THE NERVOUS SYSTEM IN REGENERATING HYDRA: THE EFFECT OF NEUROPHARMACOLOGICAL AGENTS. The Journal of experimental zoology, 1963, Volume: 154 Topics: Amphetamine; Amphetamines; Animals; Atropine; Autonomic Agents; Biphenyl Compounds; Chlorpromazine; Cnidaria; Decamethonium Compounds; Dihydroxyphenylalanine; Enzyme Inhibitors; Ergotamine; Hexamethonium Compounds; Histocytochemistry; Histology; Hydra; Isoflurophate; Lidocaine; Methyldopa; Nervous System; Pharmacology; Physostigmine; Regeneration; Research; Reserpine; Tubocurarine	1963