Compounds > isoniazid

isoniazid and isonicotinyl-nad

isoniazid has been researched along with isonicotinyl-nad in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jacobs, WR; Miesel, L; Rozwarski, DA; Sacchettini, JC1
Basso, LA; de Azevedo, WF; Dias, MV; Fadel, V; Prado, AM; Santos, DS; Vasconcelos, IB1
Choong, YS; Ibrahim, P; Sadikun, A; Scior, T; Wahab, HA1
Carpena, X; Donald, LJ; Feliz, M; Fita, I; Loewen, PC; Pons, M; Wiseman, B1
Bernadou, J; Bernardes-Génisson, V; Constant, P; Delaine, T; Meunier, B; Quémard, A1
Belisle, JT; Boom, WH; Eisenach, KD; Johnson, JL; Joloba, ML; Lenaerts, AJ; Mahapatra, S; Woolhiser, LK1
Aljuhani, N; Khan, SR; Michail, K; Morgan, AG; Siraki, AG; Srivastava, N; Whittal, RM1

Reviews

1 review(s) available for isoniazid and isonicotinyl-nad

ArticleYear
Mechanisms for isoniazid action and resistance.
    Novartis Foundation symposium, 1998, Volume: 217

    Topics: Bacterial Proteins; Drug Resistance, Microbial; Isoniazid; Mutation; Mycobacterium smegmatis; Mycolic Acids; NAD; NADH Dehydrogenase; Oxidoreductases; Peroxidases

1998

Other Studies

6 other study(ies) available for isoniazid and isonicotinyl-nad

ArticleYear
Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
    Journal of structural biology, 2007, Volume: 159, Issue:3

    Topics: Bacterial Proteins; Crystallography, X-Ray; Drug Resistance, Bacterial; Isoniazid; Mutation, Missense; Mycobacterium tuberculosis; NAD; NADH, NADPH Oxidoreductases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation

2007
Elucidating isoniazid resistance using molecular modeling.
    Journal of chemical information and modeling, 2009, Volume: 49, Issue:1

    Topics: Bacterial Proteins; Catalytic Domain; Drug Resistance, Bacterial; Genes, Bacterial; Informatics; Isoniazid; Ligands; Models, Molecular; Mutation; Mycobacterium tuberculosis; NAD; Oxidoreductases; Protein Conformation; Thermodynamics; Water

2009
Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
    The Journal of biological chemistry, 2010, Aug-20, Volume: 285, Issue:34

    Topics: Antitubercular Agents; Bacterial Proteins; Binding Sites; Burkholderia pseudomallei; Catalase; Crystallography, X-Ray; Isoniazid; Kinetics; NAD; Peroxidases; Prodrugs

2010
Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:10

    Topics: Antitubercular Agents; Bacterial Proteins; Humans; Isoniazid; Mycobacterium tuberculosis; NAD; Oxidoreductases; Tuberculosis

2010
A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1

    Topics: Animals; Antitubercular Agents; Bacterial Proteins; Biotransformation; Catalase; Chromatography, Liquid; Drug Resistance, Bacterial; Female; Humans; Isoniazid; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Oxidoreductases; Tuberculosis, Pulmonary

2012
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
    Biochemical pharmacology, 2016, Apr-15, Volume: 106

    Topics: Antitubercular Agents; Humans; Hydrazines; Isoniazid; NAD; Neutrophil Activation; Neutrophils; Peroxidase; Primary Cell Culture; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate

2016