isoniazid and heme
isoniazid has been researched along with heme in 59 studies
Research
Studies (59)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (55.93) | 18.7374 |
| 1990's | 5 (8.47) | 18.2507 |
| 2000's | 9 (15.25) | 29.6817 |
| 2010's | 10 (16.95) | 24.3611 |
| 2020's | 2 (3.39) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Franco, RS; Hogg, JW; Martelo, OJ | 1 |
| Hoffbrand, AV; Konopka, L | 1 |
| Hoy, T; Humphrys, J; Jacobs, A; Ponka, P; Williams, A | 1 |
| Fuhr, JE; Leisy, M; Overton, M | 1 |
| Fuhr, JE; Townes, TM | 1 |
| Koller, ME; Prante, PH; Romslo, I; Ulvik, R | 1 |
| Guiliani, D; Minak, V; Morse, BS; Nussbaum, M | 1 |
| Eisenstein, RS; Garcia-Mayol, D; Munro, HN; Pettingell, W | 1 |
| al-Nakeeb, A; Garrick, LM; Garrick, MD; Gniecko, K; Hoke, JE; Ponka, P | 1 |
| Basson, K; Uebel, RA; van der Walt, BJ; van Zyl, JM | 1 |
| Decal, DL; Umlas, ME; Whittington, KB; Zucker, RM | 1 |
| Ponka, P; Schulman, HM | 3 |
| Fuhr, JE; Gengozian, N | 1 |
| Martinez-Medellin, J; Schulman, HM; Sidloi, R | 1 |
| Sullivan, AL; Weintraub, LR | 1 |
| Neuwirt, J; Ponka, P | 2 |
| Borová, J; Neuwirt, J; Ponka, P | 6 |
| Iacopetta, B; Morgan, E | 1 |
| Borová, J; Fuchs, O; Hradilek, A; Neuwirt, J | 3 |
| Jacobs, A; May, A; Peters, RE | 1 |
| Borová, J; Fuchs, O; Hradilek, A; Neuwirt, J; Trávnícek, M | 1 |
| Salem, Z; Yunis, AA | 1 |
| Bottomley, SS | 1 |
| Ponka, P; Schulman, HM; Wilczynska, A | 1 |
| Hoffman, LM; Ross, J | 1 |
| Fujii, J; Niikawa, N; Seo, HG; Soejima, H; Taniguchi, N | 1 |
| Krantz, SB; Muta, K | 1 |
| Chan, RY; Kühn, LC; Ponka, P; Schulman, HM; Seiser, C | 1 |
| Franklin Bunn, H; Horiguchi, H | 1 |
| Chouchane, S; Lippai, I; Magliozzo, RS | 1 |
| Lukat-Rodgers, GS; Rodgers, KR; Rusnak, F; Wengenack, NL | 1 |
| Aitken, SM; English, AM; Percival, MD; Turnbull, JL | 1 |
| Chouchane, S; Girotto, S; Kapetanaki, S; Magliozzo, RS; Schelvis, JP; Yu, S | 1 |
| Banci, L; Bodiguel, J; Brown, KA; Eady, NA; Jamart-Grégoire, B; Jones, JN; Moody, PC; Pierattelli, R; Raven, EL | 1 |
| Brown, KA; Macdonald, IK; Metcalfe, C; Moody, PC; Murphy, EJ; Raven, EL | 1 |
| Acharya, BN; Kaushik, MP; Saraswat, D | 1 |
| Magliozzo, RS; Metlitsky, L; Ranguelova, K; Schelvis, JP; Suarez, J; Yu, S; Zhao, X | 1 |
| Bhushan, A; Kaur, P; Kumar, RP; Pandey, N; Sharma, S; Singh, AK; Singh, N; Singh, TP; Sinha, M | 1 |
| Ascenzi, P; Bolli, A; Coletta, M; di Masi, A; Fanali, G; Fasano, M; Tundo, GR | 1 |
| Cheng, J; Csanaky, IL; Gonzalez, FJ; Klaassen, CD; Li, F; Lu, J; Ma, X; Matsubara, T; Wang, L | 1 |
| Ascenzi, P; Cao, Y; Ciaccio, C; Coletta, A; Coletta, M; Fanali, G; Fasano, M; Leboffe, L; Marini, S; Pesce, A; Trezza, V | 1 |
| Cowley, PM; DeRuisseau, KC; DeRuisseau, LR; Doyle, RP; Fazen, CH; Park, YM | 1 |
| Goodwin, DC; Ndontsa, EN; Njuma, OJ | 1 |
| Carpena, X; Fiorin, G; Fita, I; Loewen, PC; Rovira, C; Vidossich, P | 1 |
| Hirabayashi, K; Kamachi, S; Shigeoka, S; Tada, T; Tamoi, M; Wada, K | 2 |
| Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L | 1 |
| Brewer, CT; Chen, T; Kodali, K; Peng, J; Shaw, TI; Wu, J | 1 |
| Kumar, V; Legac, J; Rani, A; Rosenthal, PJ; Sharma, A; Singh, P | 1 |
Reviews
4 review(s) available for isoniazid and heme
| Article | Year |
|---|---|
Sideroblastic anemias. An approach to diagnosis and management.
Topics: Alcoholism; Anemia, Sideroblastic; Erythrocytes, Abnormal; Female; Folic Acid Deficiency; Genes; Heme; Humans; Iron; Isoniazid; Lead Poisoning; Male; Pyridoxine; Sex Chromosomes; Thalassemia; Transferrin | 1973 |
Drug-induced mitochondrial damage and sideroblastic change.
Topics: Anemia, Sideroblastic; Animals; Bone Marrow; Chloramphenicol; Cycloserine; Erythrocytes; Ethanol; Heme; Humans; Iron; Isoniazid; Lead Poisoning; Mitochondria; Phenacetin; Pyrazinamide; Pyridoxine; Rats | 1980 |
Sideroblastic anaemia.
Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Sideroblastic; Blood Transfusion; Bone Marrow; Chloramphenicol; Deferoxamine; Erythroblasts; Ethanol; Female; Ferrochelatase; Heme; Hemochromatosis; Humans; Iron Deficiencies; Isoniazid; Male; Melphalan; Myeloproliferative Disorders; Pyridoxine; Syndrome | 1982 |
Catalase in peroxidase clothing: Interdependent cooperation of two cofactors in the catalytic versatility of KatG.
Topics: Antitubercular Agents; Archaea; Bacteria; Bacterial Proteins; Catalase; Coenzymes; Heme; Isoniazid; Methionine; Models, Molecular; Mycobacterium tuberculosis; Peroxidase; Prodrugs; Tryptophan; Tyrosine | 2014 |
Other Studies
55 other study(ies) available for isoniazid and heme
| Article | Year |
|---|---|
The effect of INH-inhibited heme synthesis on globin synthesis.
Topics: Animals; Cell-Free System; Depression, Chemical; Female; Globins; Heme; Isoniazid; Rabbits | 1979 |
Haem synthesis in sideroblastic anaemia.
Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Sideroblastic; Bone Marrow; Female; Ferrochelatase; Heme; Humans; Isoniazid; Male; Middle Aged; Pyridoxine | 1979 |
Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone.
Topics: Animals; Deferoxamine; Heme; Iron; Iron Chelating Agents; Isoniazid; Liver; Male; Pyridoxal; Pyridoxine; Rats; Spleen | 1979 |
The effect of cobalt on haemoglobin synthesis in primate reticulocytes.
Topics: Aminolevulinic Acid; Animals; Callitrichinae; Cobalt; Dose-Response Relationship, Drug; Globins; Haplorhini; Heme; Hemoglobins; Iron; Isoniazid; Reticulocytes | 1975 |
Protection by cycloheximide from hyperthermic inhibition of protein synthesis in human reticulocytes.
Topics: Cycloheximide; Female; Fetal Blood; Heme; Hemoglobins; Hot Temperature; Humans; Infant, Newborn; Isoniazid; Leucine; Pregnancy; Reticulocytes; Time Factors | 1977 |
Effect of hemin and isonicotinic acid hydrazide on the uptake of iron from transferrin by isolated rat liver mitochondria.
Topics: Animals; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Heme; Hemin; Iron; Isoniazid; Kinetics; Mitochondria, Liver; Rats; Transferrin | 1976 |
Abnormal erythroid maturation in mice induced by isoniazid.
Topics: Anemia, Sideroblastic; Animals; Blood Cell Count; Erythrocytes; Erythropoiesis; Erythropoietin; Female; Heme; Injections, Intradermal; Injections, Intravenous; Isoniazid; Mice; Reticulocytes | 1975 |
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.
Topics: Animals; Cell Line; Deferoxamine; Enzyme Induction; Ferritins; Fibroblasts; Heme; Heme Oxygenase (Decyclizing); Iron; Isoniazid; Kinetics; Pyridoxal; Rats | 1991 |
Ferric-salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat.
Topics: Animals; Cells, Cultured; Globins; Glycine; Heme; Iron; Iron Chelating Agents; Isoniazid; Porphyrins; Rats; Reticulocytes; Transferrin | 1991 |
Isoniazid-mediated irreversible inhibition of the myeloperoxidase antimicrobial system of the human neutrophil and the effect of thyronines.
Topics: Chlorides; Heme; Humans; Hydrogen Peroxide; Isoniazid; Models, Chemical; Neutrophils; Oxidation-Reduction; Peroxidase; Spectrophotometry, Ultraviolet; Thyronines; Thyroxine | 1989 |
Differential hemoglobin synthesis in murine erythroleukemic cells: hemin effects.
Topics: Animals; Butyrates; Butyric Acid; Cell Differentiation; Clone Cells; Friend murine leukemia virus; Heme; Hemin; Hemoglobins; Isoniazid; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice | 1987 |
Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis.
Topics: 2,2'-Dipyridyl; Animals; Erythrocytes; Glycine; Heme; Heptanoates; Iron; Isoniazid; Porphyrins; Protoporphyrins; Pyridoxal; Rabbits; Reticulocytes; Transferrin | 1985 |
Acquisition of iron from transferrin regulates reticulocyte heme synthesis.
Topics: Aminolevulinic Acid; Animals; Carbon Radioisotopes; Glycine; Heme; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Rabbits; Reticulocytes; Transferrin | 1985 |
Coordination of heme and globin synthesis in primate reticulocytes.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Globins; Haplorhini; Heme; Hemoglobins; Isoniazid; Kinetics; Leucine; Levulinic Acids; Reticulocytes; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1973 |
The reticulocyte-mediated release of iron and bicarbonate from transferrin: effect of metabolic inhibitors.
Topics: Animals; Antimetabolites; Arsenic; Azides; Bicarbonates; Binding Sites; Carbon Radioisotopes; Cobalt; Cyanides; Cycloheximide; Dinitrophenols; Ethylmaleimide; Fluorides; Heme; Iodoacetates; Iron; Iron Radioisotopes; Isoniazid; Oligomycins; Protein Binding; Reticulocytes; Rotenone; Time Factors; Transferrin | 1974 |
The regulation of heme synthesis in erythroid cells by the feedback inhibition of cellular uptake of substrates.
Topics: Amino Acids; Animals; Biological Transport; Erythrocytes; Feedback; Heme; Iron; Iron Radioisotopes; Isoniazid; Rabbits; Reticulocytes | 1972 |
The use of exogenous -aminolaevulinic acid for the studies of the regulation of haem synthesis in rabbit reticulocytes.
Topics: 5-Aminolevulinate Synthetase; Age Factors; Animals; Carbon Isotopes; Cycloheximide; Globins; Glycine; Heme; In Vitro Techniques; Iron; Iron Isotopes; Isoniazid; Levulinic Acids; Models, Chemical; Penicillamine; Protein Binding; Rabbits; Reticulocytes; Transferrin | 1973 |
Study of intracellular iron distribution in rabbit reticulocytes with normal and inhibited heme synthesis.
Topics: Animals; Biological Transport; Centrifugation, Density Gradient; Chromatography, Gel; Electrophoresis, Disc; Ferritins; Heme; Iodine Radioisotopes; Iron; Iron Radioisotopes; Isoniazid; Isotope Labeling; Mitochondria; Models, Biological; Molecular Weight; Oxidative Phosphorylation; Oxygen Consumption; Rabbits; Reticulocytes; Subcellular Fractions; Time Factors; Transferrin | 1973 |
The role of heme in the release of iron from transferrin in reticulocytes.
Topics: Animals; Cycloheximide; Heme; Iodine Radioisotopes; Iron; Iron Radioisotopes; Isoniazid; Mitochondria; Protein Binding; Pyridines; Rabbits; Reticulocytes; Transferrin | 1974 |
Heme and the production of delta-aminolevulinic acid in rabbit reticulocytes.
Topics: 5-Aminolevulinate Synthetase; Animals; Carbon Radioisotopes; Cattle; Cycloheximide; Globins; Glycine; Heme; Iron; Iron Radioisotopes; Isoniazid; Levulinic Acids; Mitochondria; Pyridines; Rabbits; Reticulocytes; Serum Albumin, Bovine; Time Factors | 1974 |
Evidence for the presence of free and protein-bound nonhemoglobin heme in rabbit reticulocytes.
Topics: Animals; Blood Proteins; Carbon Isotopes; Chromatography, Gel; Chromatography, Ion Exchange; Cycloheximide; Glycine; Heme; Hemoglobins; In Vitro Techniques; Iron; Iron Isotopes; Isoniazid; Protein Binding; Rabbits; Reticulocytes | 1972 |
Regulation of iron entry into reticulocytes. II. Relationship between hemoglobin synthesis and entry of iron into reticulocytes.
Topics: Animals; Biological Transport; Carbon Isotopes; Cell Membrane; Chloramphenicol; Cycloheximide; Emetine; Fluorides; Globins; Glycine; Heme; Hemoglobins; In Vitro Techniques; Iron; Iron Isotopes; Isoniazid; Penicillamine; Puromycin; Pyridoxal Phosphate; Rabbits; Reticulocytes; Tryptamines | 1971 |
Heme inhibits transferrin endocytosis in immature erythroid cells.
Topics: Animals; Cycloheximide; Endocytosis; Erythrocyte Aging; Erythrocytes; Heme; Hemin; Heptanoates; Hydrogen-Ion Concentration; Iron; Isoniazid; Liver; Rabbits; Rats; Reticulocytes; Transferrin | 1984 |
Effect of hemin and heme synthesis inhibitors on cellular protein synthesis.
Topics: 2,2'-Dipyridyl; Anemia; Animals; Cell Line; Heme; Hemin; Hemoglobins; In Vitro Techniques; Isoniazid; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred ICR; Penicillamine; Protein Biosynthesis; Spleen | 1984 |
Globin chain synthesis ratios in sideroblastic anaemia.
Topics: Anemia, Sideroblastic; Female; Globins; Heme; Humans; Iron Deficiencies; Isoniazid; Male; Reticulocytes | 1983 |
The effect of heme on intracellular iron pools during differentiation of Friend erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Ferrochelatase; Friend murine leukemia virus; Heme; Hemin; Iron; Isoniazid; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Mitochondria | 1981 |
Effect of heme on globin messenger RNA synthesis.
Topics: Animals; Cell Line; Cells, Cultured; Globins; Heme; Hemin; Isoniazid; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred ICR; Nucleic Acid Hybridization; Penicillamine; RNA, Messenger; Spleen | 1981 |
Ferric pyridoxal isonicotinoyl hydrazone can provide iron for heme synthesis in reticulocytes.
Topics: Animals; Ferric Compounds; Heme; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Pyridoxal; Rabbits; Reticulocytes; Transferrin | 1982 |
The stimulation of globin synthesis by cobalt in reticulocytes with inhibited heme synthesis.
Topics: Animals; Cobalt; Globins; Heme; Heptanoates; Isoniazid; Keto Acids; Kinetics; Protein Biosynthesis; Rabbits; Reticulocytes | 1981 |
The role of heme in the regulation of iron uptake during Friend cell differentiation.
Topics: Animals; Biological Transport; Cell Differentiation; Cell Line; Heme; Iron; Isoniazid; Kinetics; Leukemia, Experimental; Mice | 1981 |
The role of heme in the maturation of erythroblasts: the effects of inhibition of pyridoxine metabolism.
Topics: Animals; Cell Division; Cell Survival; Erythroblasts; Erythrocytes; Erythropoiesis; Globins; Heme; Isoniazid; Mice; Protein Biosynthesis; Pyridoxine; RNA, Messenger; Transcription, Genetic | 1980 |
Iron and transferrin distribution in reticulocytes incubated with heme synthesis inhibitors.
Topics: Animals; Heme; Iron; Isoniazid; Kinetics; Penicillamine; Rabbits; Reticulocytes; Transferrin | 1980 |
Heme requirement for production of active endothelial nitric oxide synthase in baculovirus-infected insect cells.
Topics: Amino Acid Oxidoreductases; Aminolevulinic Acid; Animals; Base Sequence; Cell Line; Cloning, Molecular; DNA; DNA Primers; Endothelium, Vascular; Flavins; Gene Expression; Heme; Humans; Isoniazid; Kinetics; Molecular Sequence Data; Nitric Oxide Synthase; Nitrites; Penicillamine; Polymerase Chain Reaction; Recombinant Proteins; Spodoptera; Transfection | 1995 |
Inhibition of heme synthesis induces apoptosis in human erythroid progenitor cells.
Topics: Apoptosis; Cells, Cultured; Culture Media; Erythroid Precursor Cells; Erythropoietin; Ferritins; Heme; Heptanoates; Humans; Isoniazid; Proto-Oncogene Proteins c-myc; Recombinant Proteins; Stem Cells; Transferrin | 1995 |
Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Erythroid Precursor Cells; Gene Expression Regulation; Heme; Heptanoates; Iron; Iron-Regulatory Proteins; Isoniazid; Mice; Receptors, Transferrin; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 1994 |
Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis.
Topics: Cell Survival; Deferoxamine; Enzyme Inhibitors; Erythropoietin; Heme; Heptanoates; Humans; Isoniazid; Protoporphyrins; Tumor Cells, Cultured | 2000 |
Catalase-peroxidase (Mycobacterium tuberculosis KatG) catalysis and isoniazid activation.
Topics: Bacterial Proteins; Dimerization; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Iron; Isoniazid; Mycobacterium tuberculosis; Peroxidases; Recombinant Proteins; Spectrum Analysis, Raman | 2000 |
Carbon monoxide adducts of KatG and KatG(S315T) as probes of the heme site and isoniazid binding.
Topics: Amino Acid Substitution; Antitubercular Agents; Bacterial Proteins; Binding Sites; Carbon Monoxide; Electron Spin Resonance Spectroscopy; Ferric Compounds; Heme; Isoniazid; Mycobacterium tuberculosis; Peroxidases; Serine; Spectrum Analysis, Raman; Threonine | 2001 |
Thermodynamic analysis of the binding of aromatic hydroxamic acid analogues to ferric horseradish peroxidase.
Topics: Benzamides; Binding Sites; Buffers; Calorimetry; Heme; Horseradish Peroxidase; Hydrazines; Hydrogen-Ion Concentration; Hydroxamic Acids; Hydroxylamines; Isoenzymes; Isoniazid; Models, Chemical; Nicotinic Acids; Salicylamides; Substrate Specificity; Thermodynamics; Titrimetry | 2001 |
Conformational differences in Mycobacterium tuberculosis catalase-peroxidase KatG and its S315T mutant revealed by resonance Raman spectroscopy.
Topics: Amino Acid Substitution; Bacterial Proteins; Benzoates; Binding Sites; Catalase; Drug Resistance, Microbial; Electron Spin Resonance Spectroscopy; Ferric Compounds; Ferrous Compounds; Heme; Hydroxamic Acids; Isoniazid; Mutagenesis, Site-Directed; Mutation; Mycobacterium tuberculosis; Oxidation-Reduction; Peroxidase; Peroxidases; Protein Conformation; Recombinant Proteins; Spectrum Analysis, Raman; Spin Labels | 2003 |
Enzyme-catalyzed mechanism of isoniazid activation in class I and class III peroxidases.
Topics: Antitubercular Agents; Bacterial Proteins; Binding Sites; Chromatography, High Pressure Liquid; Heme; Horseradish Peroxidase; Isoniazid; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mycobacterium tuberculosis; Oxygen; Peroxidase; Peroxidases; Protein Binding; Protein Conformation; Protons; Protoporphyrins; Software | 2004 |
The tuberculosis prodrug isoniazid bound to activating peroxidases.
Topics: Antitubercular Agents; Ascorbate Peroxidases; Bacterial Proteins; Binding Sites; Catalase; Crystallography, X-Ray; Cytochrome-c Peroxidase; Drug Resistance, Bacterial; Heme; Isoniazid; Mutation; Mycobacterium tuberculosis; Peroxidases; Prodrugs; Protein Binding; Protein Structure, Tertiary; Structural Homology, Protein; Tuberculosis | 2008 |
Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway.
Topics: Animals; Antimalarials; Drug Discovery; Heme; Isoniazid; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Small Molecule Libraries; Stereoisomerism | 2008 |
Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant.
Topics: Amino Acid Substitution; Bacterial Proteins; Catalase; Enzyme Stability; Heme; Hydrogen Peroxide; Isoniazid; Models, Chemical; Mutation, Missense; Mycobacterium tuberculosis; Oxidation-Reduction; Oxidative Stress; Prodrugs; Protein Structure, Tertiary | 2009 |
Mode of binding of the tuberculosis prodrug isoniazid to heme peroxidases: binding studies and crystal structure of bovine lactoperoxidase with isoniazid at 2.7 A resolution.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Binding Sites; Cattle; Heme; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Isoniazid; Lactoperoxidase; Mycobacterium tuberculosis; Peroxidases; Prodrugs; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2010 |
Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme-albumin.
Topics: Binding Sites; Heme; Humans; Isoniazid; Models, Molecular; Peroxynitrous Acid; Rifampin; Serum Albumin; Structure-Activity Relationship | 2011 |
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Heme; Humans; Isoniazid; Liver; Male; Mice; Mice, Transgenic; Pregnane X Receptor; Protoporphyrins; Receptors, Steroid; Rifampin | 2013 |
Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.
Topics: Antitubercular Agents; Azides; Bacterial Proteins; Biocatalysis; Carbon Monoxide; Heme; Isomerism; Isoniazid; Molecular Docking Simulation; Mycobacterium tuberculosis; Oxygen; Peroxynitrous Acid; Protein Binding; Protein Conformation; Truncated Hemoglobins | 2013 |
Aging-related changes in the iron status of skeletal muscle.
Topics: Aging; Animals; Cation Transport Proteins; Ferritins; Gene Expression; Heme; Iron; Iron Chelating Agents; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Isoniazid; Male; Muscle Contraction; Muscle, Skeletal; Muscular Atrophy; Pyridoxal; Rats; Rats, Inbred BN; Rats, Inbred F344; Receptors, Transferrin; RNA, Messenger; Sarcopenia | 2013 |
Binding of the antitubercular pro-drug isoniazid in the heme access channel of catalase-peroxidase (KatG). A combined structural and metadynamics investigation.
Topics: Antitubercular Agents; Bacteria; Bacterial Proteins; Catalytic Domain; Heme; Isoniazid; Models, Molecular; Molecular Dynamics Simulation; Peroxidases; Prodrugs; Protein Binding; Thermodynamics | 2014 |
The crystal structure of isoniazid-bound KatG catalase-peroxidase from Synechococcus elongatus PCC7942.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antitubercular Agents; Bacterial Proteins; Binding Sites; Catalase; Crystallography, X-Ray; Heme; Isoniazid; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peroxidases; Protein Conformation; Sequence Homology, Amino Acid; Static Electricity; Synechococcus | 2015 |
Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid.
Topics: Amino Acid Substitution; Antitubercular Agents; Bacterial Proteins; Crystallography, X-Ray; Heme; Isoniazid; Mutation, Missense; Peroxidases; Synechococcus | 2015 |
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells; Hepatocytes; Humans; Hydrazines; Iron; Isoniazid; Liver; Mice, Inbred C57BL; Mice, Transgenic; Protoporphyrins; Pyridoxal; Rifampin; Vitamin B 6 | 2019 |
Toxicoproteomic Profiling of
Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Heme; Homocysteine; Iron-Sulfur Proteins; Isoniazid; Liver; Mice; Mice, Inbred C57BL; Niacinamide; Oxidative Stress; Proteome; Rifampin; Vitamin B 6 | 2020 |
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.
Topics: Animals; Antimalarials; Chlorocebus aethiops; Heme; In Vitro Techniques; Isoniazid; Phthalimides; Plasmodium falciparum; Polymerization; Quinolines; Structure-Activity Relationship; Vero Cells | 2021 |